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MCID: ANT023
MIFTS: 29

Anterior Scleritis

Categories: Eye diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Anterior Scleritis

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MalaCards integrated aliases for Anterior Scleritis:

Name: Anterior Scleritis 12 15 70

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:13794
ICD9CM 34 379.03
SNOMED-CT 67 63454000
ICD10 32 H15.01
UMLS 70 C0155353
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Summaries for Anterior Scleritis

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MalaCards based summary : Anterior Scleritis is related to scleritis and iridocyclitis. An important gene associated with Anterior Scleritis is IL1RAPL2 (Interleukin 1 Receptor Accessory Protein Like 2), and among its related pathways/superpathways is Overview of nanoparticle effects. The drugs Clotrimazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial.

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Related Diseases for Anterior Scleritis

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Diseases in the Scleritis family:

Posterior Scleritis Anterior Scleritis

Diseases related to Anterior Scleritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 383)
# Related Disease Score Top Affiliating Genes
1 scleritis 30.5 TNF PRTN3 IL1RAPL2 CRP
2 iridocyclitis 29.8 TNF CRP ACE
3 endophthalmitis 29.7 TNF CRP
4 vasculitis 29.6 TNF PRTN3 CRP
5 keratopathy 29.6 TNF KRT12
6 septic arthritis 29.6 TNF CRP
7 erythema nodosum 29.6 TNF CRP
8 rheumatic fever 29.5 TNF ACE
9 granulomatosis with polyangiitis 29.4 TNF PRTN3 CRP
10 autoimmune disease 29.1 TNF PRTN3 IL1RAPL2 CRP
11 rheumatoid arthritis 29.1 TNF PRTN3 IL1RAPL2 CRP
12 scleroperikeratitis 11.2
13 sclerosing keratitis 11.2
14 brawny scleritis 11.1
15 uveitis 10.4
16 wells syndrome 10.2 IL1RAPL2 CRP
17 acute cholangitis 10.2 IL1RAPL2 CRP
18 purulent acute otitis media 10.2 PRTN3 CRP
19 frontal sinusitis 10.2 PRTN3 CRP
20 orbital plasma cell granuloma 10.2 PRTN3 CRP
21 bicipital tenosynovitis 10.2 PRTN3 CRP
22 ethmoid sinusitis 10.2 PRTN3 CRP
23 granulomatous myositis 10.2 PRTN3 ACE
24 splenic tuberculosis 10.2 PRTN3 CRP
25 subacute bacterial endocarditis 10.2 PRTN3 CRP
26 juvenile arthritis 10.2 IL1RAPL2 CRP
27 branch retinal artery occlusion 10.2 PRTN3 CRP
28 schnitzler syndrome 10.2 IL1RAPL2 CRP
29 mastoiditis 10.2 PRTN3 CRP
30 cogan syndrome 10.2 PRTN3 CRP
31 splenic infarction 10.2 PRTN3 CRP
32 maxillary sinusitis 10.2 PRTN3 CRP
33 pyuria 10.2 PRTN3 CRP
34 clostridium difficile colitis 10.2 IL1RAPL2 CRP
35 central retinal artery occlusion 10.2 PRTN3 CRP
36 tracheal disease 10.2 PRTN3 CRP
37 nonbacterial thrombotic endocarditis 10.1 PRTN3 CRP
38 rapidly progressive glomerulonephritis 10.1 PRTN3 CRP
39 acute dacryoadenitis 10.1 CRP ACE
40 mediastinum teratoma 10.1 CRP ACE
41 cardiac tuberculosis 10.1 CRP ACE
42 silent myocardial infarction 10.1 CRP ACE
43 urinary tract infection 10.1 CRP ACE
44 neuroretinitis 10.1 CRP ACE
45 optic papillitis 10.1 CRP ACE
46 generalized atherosclerosis 10.1 CRP ACE
47 intracranial embolism 10.1 CRP ACE
48 retinal artery occlusion 10.1 CRP ACE
49 cat-scratch disease 10.1 CRP ACE
50 first-degree atrioventricular block 10.1 CRP ACE

Graphical network of the top 20 diseases related to Anterior Scleritis:



Diseases related to Anterior Scleritis
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Symptoms & Phenotypes for Anterior Scleritis

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Drugs & Therapeutics for Anterior Scleritis

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Drugs for Anterior Scleritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clotrimazole Approved, Vet_approved Phase 1, Phase 2 23593-75-1 2812
2
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
3
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 6436030 5284616
4 Antibiotics, Antitubercular Phase 1, Phase 2
5 Immunosuppressive Agents Phase 1, Phase 2
6 Anti-Bacterial Agents Phase 1, Phase 2
7 Anti-Infective Agents Phase 1, Phase 2
8 Immunologic Factors Phase 1, Phase 2
9 Antifungal Agents Phase 1, Phase 2
10
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
11
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
12 Pharmaceutical Solutions Phase 1
13 Gastrointestinal Agents Phase 1
14 Dexamethasone 21-phosphate Phase 1
15 Ophthalmic Solutions Phase 1
16 Hormone Antagonists Phase 1
17 Hormones Phase 1
18 Antineoplastic Agents, Hormonal Phase 1
19
protease inhibitors Phase 1
20 Antiemetics Phase 1
21 glucocorticoids Phase 1
22 BB 1101 Phase 1
23 Anti-Inflammatory Agents Phase 1
24 HIV Protease Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase I/II Study to Investigate Subconjunctival Sirolimus for the Treatment of Active Autoimmune Non-Necrotizing Anterior Scleritis Completed NCT01517074 Phase 1, Phase 2 Sirolimus
2 Iontophoresis Delivery of Dexamethasone Phosphate for Non-infectious, Non-necrotizing Anterior Scleritis, Phase 1 Dose-varying Study Completed NCT01059955 Phase 1 Dexamethasone Phosphate Ophthalmic Solution (EGP-437);Dexamethasone phosphate ophthalmic solution

Search NIH Clinical Center for Anterior Scleritis

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Genetic Tests for Anterior Scleritis

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Anatomical Context for Anterior Scleritis

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MalaCards organs/tissues related to Anterior Scleritis:

40
Eye, T Cells, Endothelial, Neutrophil
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Publications for Anterior Scleritis

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Articles related to Anterior Scleritis:

(show top 50) (show all 156)
# Title Authors PMID Year
1
Experience With 0.1% Tacrolimus Eye Drop for Noninfectious, Non-necrotizing Anterior Scleritis. 61
32404650 2021
2
Remission of Non-Infectious Anterior Scleritis: Incidence and Predictive Factors. 61
30951689 2021
3
Idiopathic nodular anterior scleritis. Biomicroscopic and tomographic findings. 61
33579527 2021
4
Recalcitrant infective scleritis masquerading an autoimmune necrotising scleritis: a primary presentation of biopsy-proven granulomatosis with polyangiitis. 61
33472807 2021
5
Optical Coherence Tomography Findings in Nodular Anterior Scleritis due to Post-Streptococcal Syndrome. 61
33520137 2021
6
Nodular anterior scleritis associated with Berger's disease. 61
33470345 2021
7
Foreign body episcleral suture granulomas mimicking nodular anterior scleritis. 61
33127706 2020
8
Pediatric Uveitis and Scleritis in a Multi-Ethnic Asian Population. 61
32643984 2020
9
Aspergillus Flavus Necrotising Scleritis following Pars Plana Vitrectomy. 61
31429609 2020
10
Cataract Surgery in the Setting of Scleritis. 61
32463347 2020
11
Clinical Profile of Patients with Scleritis in Bangladesh. 61
32130057 2020
12
Eye metastasis in lung adenocarcinoma mimicking anterior scleritis: A case report. 61
32047793 2020
13
Necrotic scleral melt and fungal keratitis-a complication of subtenon triamcinolone acetonide injection. 61
31984430 2020
14
Clinical Features, Treatment, and Visual Outcomes of Japanese Patients with Posterior Scleritis. 61
30806525 2020
15
Frequently Relapsing Anterior Nodular Scleritis as the Initial Presentation of a Lethal Systemic Infection: Disseminated Tuberculosis with HIV Coinfection. 61
32082660 2020
16
Nodular Scleritis Revealing Metastasis of Breast Cancer: Diagnosis Not to Be Neglected. 61
32082666 2020
17
Pseudomonas aeruginosa scleritis initially presenting as idiopathic diffuse anterior scleritis. 61
32174745 2020
18
Tuberculous scleritis in a young Asian Indian girl-a case presentation and literature review. 61
31872314 2019
19
Anterior Scleritis in a Patient of Pemphigus Vulgaris while on Immunosuppressive Treatment. 61
31896853 2019
20
Clinical characteristics of scleritis patients with emphasized comparison of associated systemic diseases (anti-neutrophil cytoplasmic antibody-associated vasculitis and rheumatoid arthritis). 61
31183624 2019
21
Known and novel ocular toxicities of biologics, targeted agents, and traditional chemotherapeutics. 61
31098752 2019
22
Anterior Scleritis Associated with Pemphigus Vulgaris. 61
29095065 2019
23
The clinical features of posterior scleritis with serous retinal detachment: a retrospective clinical analysis. 61
31341807 2019
24
Clinical Characteristics of Ocular Sarcoidosis: A Population-Based Study 1976-2013. 61
29023165 2019
25
Pattern of Scleritis in an Egyptian Cohort. 61
30412434 2019
26
New onset or exacerbation of uveitis with infliximab: paradoxical effects? 61
31355342 2019
27
Co-occurrence of bilateral nodular anterior scleritis and large-vessel arteritis in a patient with TINU syndrome. 61
31728261 2019
28
Clinical Profile of Scleritis in Children. 61
29370565 2019
29
Antineutrophil cytoplasmic antibody-positive scleritis: Clinical profile of patients from a tuberculosis-endemic region. 61
30355867 2018
30
[Scleritis and systemic diseases: What should know the internist?] 61
29496270 2018
31
Limbal Stem Cell Deficiency Secondary to Diffuse Non-necrotizing Anterior Scleritis: A Clinicopathological Report. 61
29794824 2018
32
Iontophoretic delivery of dexamethasone phosphate for non-infectious, non-necrotising anterior scleritis, dose-finding clinical trial. 61
29666122 2018
33
Clinical profile of patients with posterior scleritis: A report from Eastern India. 61
30038152 2018
34
Indocyanine green angiography in anterior scleritis. 61
28886929 2018
35
Clinical Features and Complications of Scleritis in Chinese Patients. 61
27849414 2018
36
Patch Grafting Using an Ologen Collagen Matrix to Manage Tubal Exposure in Glaucoma Tube Shunt Surgery. 61
29643776 2018
37
Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS)-report 4: analysis and outcome of scleritis in an East Asian population. 61
28205148 2017
38
Anterior scleritis following intravitreal injections in a patient with rheumatoid arthritis: A case report. 61
29382031 2017
39
Ocular metastasis from breast carcinoma simulating anterior scleritis: a case report. 61
28844204 2017
40
Scleritis and Takayasu's disease - rare combined presentation. 61
29634707 2017
41
An OCT Study of Anterior Nodular Episcleritis and Scleritis. 61
28348907 2017
42
Gevokizumab in the Treatment of Autoimmune Non-necrotizing Anterior Scleritis: Results of a Phase I/II Clinical Trial. 61
27663070 2016
43
Uveitis Specialists and Rheumatologists Select Different Therapies for Idiopathic Non-necrotizing Anterior Scleritis. 61
27744531 2016
44
High-resolution ultrasound biomicroscopy as an adjunctive diagnostic tool for anterior scleral inflammatory disease. 61
26892270 2016
45
Anterior segment spectral domain optical coherence tomography imaging of patients with anterior scleritis. 61
26597942 2016
46
Isolated posterior scleritis associated with tuberculosis. 61
27224075 2016
47
Clinical and laboratory characteristics of ocular syphilis, co-infection, and therapy response. 61
26730177 2016
48
Flurbiprofen: A Nonselective Cyclooxygenase (COX) Inhibitor for Treatment of Noninfectious, Non-necrotizing Anterior Scleritis. 61
26308394 2016
49
Anterior tuberculous scleritis: A diagnostic challenge. 61
25817957 2015
50
Rituximab in the treatment of refractory scleritis in patients with granulomatosis with polyangiitis (Wegener's). 61
26507398 2015
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Variations for Anterior Scleritis

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Expression for Anterior Scleritis

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Search GEO for disease gene expression data for Anterior Scleritis.
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Pathways for Anterior Scleritis

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Pathways related to Anterior Scleritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Overview of nanoparticle effects 1
9.9 TNF CRP
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GO Terms for Anterior Scleritis

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Biological processes related to Anterior Scleritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.13 TNF PRTN3 IL1RAPL2
2 negative regulation of lipid storage GO:0010888 8.62 TNF CRP
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Sources for Anterior Scleritis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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