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MCID: ANT023
MIFTS: 35

Anterior Scleritis

Categories: Eye diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Anterior Scleritis

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MalaCards integrated aliases for Anterior Scleritis:

Name: Anterior Scleritis 12 15 74

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:13794
ICD9CM 36 379.03
SNOMED-CT 69 63454000
ICD10 34 H15.01
UMLS 74 C0155353
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Summaries for Anterior Scleritis

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MalaCards based summary : Anterior Scleritis is related to scleritis and loiasis. An important gene associated with Anterior Scleritis is SRCIN1 (SRC Kinase Signaling Inhibitor 1), and among its related pathways/superpathways are NF-kappaB Signaling and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. The drugs Prednisone and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include lung, b cells and eye.

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Related Diseases for Anterior Scleritis

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Diseases in the Scleritis family:

Posterior Scleritis Anterior Scleritis

Diseases related to Anterior Scleritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 scleritis 10.7
2 loiasis 10.4 MFF SRCIN1
3 deep keratitis 10.4 MFF SRCIN1
4 plantar fasciitis 10.4 MFF MRAP
5 elephantiasis 10.4 MFF SRCIN1
6 mediastinitis 10.3 MPO TEF
7 aortitis 10.3 MPO MRAP
8 chorioretinitis 10.3 MRAP SAG SRCIN1
9 gastrointestinal defects and immunodeficiency syndrome 10.3 CD19 TEF
10 chondromalacia 10.3 IL1RN TNFRSF1B
11 iritis 10.3 MRAP TNFRSF1B
12 intestinal volvulus 10.2 IL5 SRCIN1
13 tenosynovitis 10.2 MRAP TNFRSF1B
14 parasitic helminthiasis infectious disease 10.2 IL5 MFF SRCIN1
15 sulfamethoxazole allergy 10.2 IL5 MPO
16 gaucher disease, type ii 10.2 IL1RN IL5
17 bladder lymphoma 10.2 CD19 CD5
18 b cell prolymphocytic leukemia 10.2 CD19 CD5
19 panuveitis 10.2 MRAP SAG TNFRSF1B
20 intestinal schistosomiasis 10.2 IL5 SRCIN1
21 juvenile ankylosing spondylitis 10.2 IL1RN MRAP TNFRSF1B
22 uveal disease 10.2 MRAP SAG TNFRSF1B
23 pustulosis of palm and sole 10.2 IL1RN MRAP TNFRSF1B
24 intravascular large b-cell lymphoma 10.1 B2M CD5
25 mediastinal cancer 10.1 CD5 NCAM1
26 natural killer cell leukemia 10.1 MPO NCAM1
27 hypersensitivity reaction type iv disease 10.1 IL1RN MRAP TNFRSF1B
28 selective igg deficiency disease 10.1 CD19 NCAM1
29 filarial elephantiasis 10.1 IL5 SRCIN1
30 colon lymphoma 10.1 CD19 CD22 CD5
31 lymphoma, hodgkin, classic 10.1 CD19 CD22 CD5
32 anal canal adenocarcinoma 10.1 KRT19 TNFRSF1B
33 rheumatoid arthritis 10.1
34 arthritis 10.1
35 amyloid tumor 10.1 B2M IL1RN
36 morpheaform basal cell carcinoma 10.1 KRT19 NCAM1
37 epidural neoplasm 10.0 CD5 KRT19
38 scleral disease 10.0 IL1RN MRAP SRCIN1 TNFRSF1B
39 proteasome-associated autoinflammatory syndrome 1 10.0 IL1RAPL2 IL1RN IL5 MPO
40 vulvitis 10.0 MPO MRAP
41 cutaneous adenocystic carcinoma 10.0 B2M KRT19
42 orbital plasma cell granuloma 10.0 MRAP NCAM1 TNFRSF1B
43 cervical clear cell adenocarcinoma 10.0 KRT19 NCAM1
44 monoclonal paraproteinemia 10.0 MPO PRTN3
45 behcet syndrome 10.0 IL1RN MRAP SAG TNFRSF1B
46 anca-associated vasculitis 10.0 MPO PRTN3
47 lymphatic system cancer 10.0 CD19 CD5 NCAM1
48 non-secretory myeloma 9.9 B2M CD19
49 small intestine lymphoma 9.9 B2M CD19 CD22
50 spondyloarthropathy 1 9.9 B2M MRAP TNFRSF1B

Graphical network of the top 20 diseases related to Anterior Scleritis:



Diseases related to Anterior Scleritis
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Symptoms & Phenotypes for Anterior Scleritis

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Drugs & Therapeutics for Anterior Scleritis

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Drugs for Anterior Scleritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
2
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
3
Infliximab Approved Phase 3 170277-31-3
4
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
5 Hormones Phase 3,Phase 1
6 Antineoplastic Agents, Hormonal Phase 3,Phase 1
7 Immunologic Factors Phase 3,Phase 1,Phase 2
8 Gastrointestinal Agents Phase 3,Phase 1
9 glucocorticoids Phase 3,Phase 1
10 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
11 Anti-Inflammatory Agents Phase 3,Phase 1
12 Hormone Antagonists Phase 3,Phase 1
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1
14 Dermatologic Agents Phase 3
15 Alkylating Agents Phase 3
16 Antirheumatic Agents Phase 3
17 Antineoplastic Agents, Alkylating Phase 3
18
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 46835353 5284616 6436030
19
Everolimus Approved Phase 1, Phase 2 159351-69-6 70789204 6442177
20
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
21 Antibiotics, Antitubercular Phase 1, Phase 2
22 Anti-Infective Agents Phase 1, Phase 2
23 Anti-Bacterial Agents Phase 1, Phase 2
24 Antifungal Agents Phase 1, Phase 2
25
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
26
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
27 Ophthalmic Solutions Phase 1
28 Antiemetics Phase 1
29
protease inhibitors Phase 1
30 HIV Protease Inhibitors Phase 1
31 BB 1101 Phase 1
32 Dexamethasone 21-phosphate Phase 1
33 Peripheral Nervous System Agents Phase 1
34 Pharmaceutical Solutions Phase 1
35 Autonomic Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) Not yet recruiting NCT03088293 Phase 3 Infliximab;Cyclophosphamide
2 Sirolimus Injections for Autoimmune Scleritis Completed NCT01517074 Phase 1, Phase 2 Sirolimus
3 Iontophoresis Delivery of Dexamethasone Phosphate for Non-infectious, Non-necrotizing Anterior Scleritis, Phase 1 Dose-varying Study Completed NCT01059955 Phase 1 Dexamethasone Phosphate Ophthalmic Solution (EGP-437);Dexamethasone phosphate ophthalmic solution
4 Optical Coherence Tomography in the Diagnosis of Scleritis and Episcleritis Completed NCT01958567 Not Applicable

Search NIH Clinical Center for Anterior Scleritis

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Genetic Tests for Anterior Scleritis

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Anatomical Context for Anterior Scleritis

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MalaCards organs/tissues related to Anterior Scleritis:

42
Lung, B Cells, Eye, Breast, T Cells, Neutrophil, Bone
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Publications for Anterior Scleritis

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Articles related to Anterior Scleritis:

(show all 48)
# Title Authors Year
1
Remission Of Non-Infectious Anterior Scleritis: Incidence And Predictive Factors. ( 30951689 )
2019
2
Indocyanine green angiography in anterior scleritis. ( 28886929 )
2018
3
Iontophoretic delivery of dexamethasone phosphate for non-infectious, non-necrotising anterior scleritis, dose-finding clinical trial. ( 29666122 )
2018
4
Limbal Stem Cell Deficiency Secondary to Diffuse Non-necrotizing Anterior Scleritis: A Clinicopathological Report. ( 29794824 )
2018
5
Ocular metastasis from breast carcinoma simulating anterior scleritis: a case report. ( 28844204 )
2017
6
Anterior Scleritis Associated with Pemphigus Vulgaris. ( 29095065 )
2017
7
Anterior scleritis following intravitreal injections in a patient with rheumatoid arthritis: A case report. ( 29382031 )
2017
8
Flurbiprofen: A Nonselective Cyclooxygenase (COX) Inhibitor for Treatment of Noninfectious, Non-necrotizing Anterior Scleritis. ( 26308394 )
2016
9
Anterior segment spectral domain optical coherence tomography imaging of patients with anterior scleritis. ( 26597942 )
2016
10
Gevokizumab in the Treatment of Autoimmune Non-necrotizing Anterior Scleritis: Results of a Phase I/II Clinical Trial. ( 27663070 )
2016
11
Uveitis Specialists and Rheumatologists Select Different Therapies for Idiopathic Non-necrotizing Anterior Scleritis. ( 27744531 )
2016
12
Cotrimoxazole as a Treatment for Recurrent Idiopathic Anterior Scleritis: A Single-center Experience in 20 Patients. ( 24432898 )
2015
13
Subconjunctival sirolimus in the treatment of autoimmune non-necrotizing anterior scleritis: results of a phase I/II clinical trial. ( 25526946 )
2015
14
Adalimumab-induced remission of anterior scleritis: a very rare late manifestation of Takayasu arteritis. ( 26320134 )
2015
15
Diffuse anterior scleritis and secondary glaucoma as a manifestation of adult T-cell prolymphocytic leukemia. ( 24977988 )
2014
16
Anterior scleritis and celiac disease: a proposed association. ( 23876049 )
2013
17
Management and outcome of microbial anterior scleritis. ( 21694595 )
2011
18
Long-term, multicenter evaluation of subconjunctival injection of triamcinolone for non-necrotizing, noninfectious anterior scleritis. ( 21708408 )
2011
19
Resolution of anterior scleritis after periodontal therapy. ( 21769277 )
2011
20
Subconjunctival triamcinolone treatment for non-necrotising anterior scleritis. ( 20447959 )
2010
21
Subconjunctival triamcinolone acetonide injection in the treatment of acute noninfectious nonnecrotizing anterior scleritis. ( 20510689 )
2010
22
Trabeculectomy with mitomycin C in refractory glaucoma associated with nonnecrotizing anterior scleritis. ( 20001263 )
2009
23
Anterior scleritis as the presenting sign of metastatic lung cancer. ( 18156383 )
2008
24
Optic atrophy, necrotizing anterior scleritis and keratitis presenting in association with Streptococcal Toxic Shock Syndrome: a case report. ( 18312659 )
2008
25
Nodular non-necrotising anterior scleritis due to Nocardia nova infection. ( 16878113 )
2007
26
Necrotising anterior scleritis in a late-onset rheumatoid arthritis (LORA) patient. ( 17365805 )
2007
27
Efficacy of the IL-1 receptor antagonist, anakinra, for the treatment of diffuse anterior scleritis in rheumatoid arthritis. Report of two cases. ( 17449489 )
2007
28
Fungal endophthalmitis complicating subconjunctival injection of triamcinolone acetonide in anterior scleritis. ( 17416964 )
2006
29
The diagnosis and management of anterior scleritis. ( 15791166 )
2005
30
Celecoxib, a selective inhibitor of cyclooxygenase 2 for therapy of diffuse anterior scleritis. ( 15953441 )
2005
31
Successful treatment of refractory anterior scleritis in primary Sjogren's syndrome with rituximab. ( 15958765 )
2005
32
Subconjunctival corticosteroid injection for the treatment of non-necrotising anterior scleritis. ( 15965178 )
2005
33
Evaluation of subconjunctival triamcinolone for nonnecrotizing anterior scleritis. ( 16199269 )
2005
34
Anterior scleritis, scleral thinning, and intraocular pressure measurement. ( 16321890 )
2005
35
Therapeutic decision in anterior scleritis: our experience at a tertiary care eye center. ( 16395198 )
2005
36
Acute febrile neutrophilic dermatosis (Sweet's syndrome) with erythema nodosum and anterior scleritis. A case report. ( 16409276 )
2005
37
Anterior scleritis: three case reports and a review of the literature. ( 15296376 )
2004
38
Self-inflicted anterior scleritis. ( 12579186 )
2003
39
Bilateral centripetal lipid keratopathy with diffuse anterior scleritis. ( 12752066 )
2003
40
Anterior segment indocyanine green angiography in anterior scleritis and episcleritis. ( 13129874 )
2003
41
A prospective evaluation of subconjunctival injection of triamcinolone acetonide for resistant anterior scleritis. ( 11927443 )
2002
42
Self-inflicted anterior scleritis. ( 11150288 )
2001
43
Nodular anterior scleritis associated with ocular trauma. ( 11465321 )
2001
44
Use of topical steroid therapy in the management of nonnecrotizing anterior scleritis. ( 10396658 )
1999
45
Subconjunctival corticosteroid injections for nonnecrotizing anterior scleritis. ( 10408466 )
1999
46
Therapy of nonnecrotizing anterior scleritis with subconjunctival corticosteroid injection. ( 7777270 )
1995
47
Necrotising anterior scleritis after pterygium surgery. ( 7818874 )
1994
48
Diffuse anterior scleritis during OKT3 monoclonal antibody therapy for renal transplant rejection. ( 1555131 )
1992
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Variations for Anterior Scleritis

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Expression for Anterior Scleritis

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Search GEO for disease gene expression data for Anterior Scleritis.
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Pathways for Anterior Scleritis

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Pathways related to Anterior Scleritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
NF-kappaB Signaling 4
11.95 B2M CD19 IL1RN MPO NCAM1 TNFRSF1B
2
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 67
11.63 B2M CD19 CD22
3
Hematopoietic cell lineage 38
11.44 CD19 CD22 CD5 IL5
4
B Cell Development Pathways 66
11.16 CD19 CD22 CD5
5
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.16 CD19 CD22 CD5 IL5 MPO NCAM1
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GO Terms for Anterior Scleritis

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Cellular components related to Anterior Scleritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.56 B2M CD19 CD22 IL1RN KRT12 KRT19
2 external side of plasma membrane GO:0009897 9.46 B2M CD19 CD5 NCAM1
3 plasma membrane GO:0005886 9.4 B2M CD19 CD22 CD5 IL1RAPL2 IL1RN

Biological processes related to Anterior Scleritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.02 IL1RAPL2 IL1RN IL5 PRTN3 TNFRSF1B
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Sources for Anterior Scleritis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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