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MCID: ANT023
MIFTS: 38

Anterior Scleritis

Categories: Eye diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Anterior Scleritis

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MalaCards integrated aliases for Anterior Scleritis:

Name: Anterior Scleritis 12 15 73

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:13794
ICD10 33 H15.01
ICD9CM 35 379.03
SNOMED-CT 68 63454000
UMLS 73 C0155353
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Summaries for Anterior Scleritis

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MalaCards based summary : Anterior Scleritis is related to limbal stem cell deficiency and scleritis. An important gene associated with Anterior Scleritis is SRCIN1 (SRC Kinase Signaling Inhibitor 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and NF-kappaB Signaling. The drugs Infliximab and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include eye, lung and t cells, and related phenotypes are Reduced mammosphere formation and hematopoietic system

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Related Diseases for Anterior Scleritis

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Diseases in the Scleritis family:

Posterior Scleritis Anterior Scleritis

Diseases related to Anterior Scleritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 limbal stem cell deficiency 29.8 KRT12 KRT19
2 scleritis 10.6
3 loiasis 10.3 MFF SRCIN1
4 deep keratitis 10.3 MFF SRCIN1
5 elephantiasis 10.3 MFF SRCIN1
6 plantar fasciitis 10.3 MFF MRAP
7 chorioretinitis 10.2 MRAP SRCIN1
8 aortitis 10.2 MPO MRAP
9 chondromalacia 10.2 IL1RN TNFRSF1B
10 iritis 10.2 MRAP TNFRSF1B
11 tenosynovitis 10.2 MRAP TNFRSF1B
12 intestinal volvulus 10.2 IL5 SRCIN1
13 intestinal schistosomiasis 10.2 IL5 SRCIN1
14 sulfamethoxazole allergy 10.2 IL5 MPO
15 filarial elephantiasis 10.1 IL5 SRCIN1
16 bladder lymphoma 10.1 CD19 CD5
17 b cell prolymphocytic leukemia 10.1 CD19 CD5
18 parasitic helminthiasis infectious disease 10.1 IL5 MFF SRCIN1
19 vulvitis 10.1 MPO MRAP
20 juvenile ankylosing spondylitis 10.1 IL1RN MRAP TNFRSF1B
21 pustulosis of palm and sole 10.1 IL1RN MRAP TNFRSF1B
22 mediastinal cancer 10.1 CD5 NCAM1
23 hypersensitivity reaction type iv disease 10.1 IL1RN MRAP TNFRSF1B
24 natural killer cell leukemia 10.1 MPO NCAM1
25 intravascular large b-cell lymphoma 10.1 B2M CD5
26 selective igg deficiency disease 10.1 CD19 NCAM1
27 anal canal adenocarcinoma 10.1 KRT19 TNFRSF1B
28 diffuse infiltrative lymphocytosis syndrome 10.1 CD19 MRAP
29 epidural neoplasm 10.1 CD5 KRT19
30 colon lymphoma 10.1 CD19 CD22 CD5
31 amyloid tumor 10.1 B2M IL1RN
32 lymphoma, hodgkin, classic 10.1 CD19 CD22 CD5
33 plasma protein metabolism disease 10.1 CD19 CD5
34 morpheaform basal cell carcinoma 10.0 KRT19 NCAM1
35 rheumatoid arthritis 10.0
36 arthritis 10.0
37 acute salpingitis 10.0 MRAP TNFRSF1B
38 scleral disease 10.0 IL1RN MRAP SRCIN1 TNFRSF1B
39 cervical clear cell adenocarcinoma 10.0 KRT19 NCAM1
40 norwegian scabies 10.0 IL5 TNFRSF1B
41 orbital plasma cell granuloma 10.0 MRAP NCAM1 TNFRSF1B
42 cutaneous adenocystic carcinoma 10.0 B2M KRT19
43 non-secretory myeloma 10.0 B2M CD19
44 proteasome-associated autoinflammatory syndrome 1 10.0 IL1RAPL2 IL1RN IL5 MPO
45 monoclonal paraproteinemia 10.0 MPO PRTN3
46 anca-associated vasculitis 10.0 MPO PRTN3
47 behcet syndrome 10.0 IL1RN MRAP TNFRSF1B
48 lymphatic system cancer 10.0 CD19 CD5 NCAM1
49 spondyloarthropathy 1 10.0 B2M MRAP TNFRSF1B
50 pericoronitis 10.0 CD19 NCAM1 TNFRSF1B

Graphical network of the top 20 diseases related to Anterior Scleritis:



Diseases related to Anterior Scleritis
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Symptoms & Phenotypes for Anterior Scleritis

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GenomeRNAi Phenotypes related to Anterior Scleritis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 CD22 CD5 IL5 NCAM1 PRTN3 TNFRSF1B

MGI Mouse Phenotypes related to Anterior Scleritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 B2M CD19 CD22 CD5 IL1RN IL5
2 immune system MP:0005387 9.28 B2M CD19 CD22 CD5 IL1RN IL5
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Drugs & Therapeutics for Anterior Scleritis

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Drugs for Anterior Scleritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 3 170277-31-3
2
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
3
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
4
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
5 Antineoplastic Agents, Hormonal Phase 3,Phase 1
6 Immunologic Factors Phase 3,Phase 1,Phase 2
7 glucocorticoids Phase 3,Phase 1
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1
9 Anti-Inflammatory Agents Phase 3,Phase 1
10 Hormones Phase 3,Phase 1
11 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
12 Gastrointestinal Agents Phase 3,Phase 1
13 Hormone Antagonists Phase 3,Phase 1
14 Antineoplastic Agents, Alkylating Phase 3
15 Alkylating Agents Phase 3
16 Antirheumatic Agents Phase 3
17 Dermatologic Agents Phase 3
18
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
19
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 46835353 6436030 5284616
20
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
21 Anti-Infective Agents Phase 1, Phase 2
22 Antibiotics, Antitubercular Phase 1, Phase 2
23 Anti-Bacterial Agents Phase 1, Phase 2
24 Antifungal Agents Phase 1, Phase 2
25
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
26
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
27 Ophthalmic Solutions Phase 1
28 Peripheral Nervous System Agents Phase 1
29 Dexamethasone 21-phosphate Phase 1
30 HIV Protease Inhibitors Phase 1
31
protease inhibitors Phase 1
32 Autonomic Agents Phase 1
33 Antiemetics Phase 1
34 BB 1101 Phase 1
35 Pharmaceutical Solutions Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) Not yet recruiting NCT03088293 Phase 3 Infliximab;Cyclophosphamide
2 Sirolimus Injections for Autoimmune Scleritis Completed NCT01517074 Phase 1, Phase 2 Sirolimus
3 Iontophoresis Delivery of Dexamethasone Phosphate for Non-infectious, Non-necrotizing Anterior Scleritis, Phase 1 Dose-varying Study Completed NCT01059955 Phase 1 Dexamethasone Phosphate Ophthalmic Solution (EGP-437);Dexamethasone phosphate ophthalmic solution
4 Optical Coherence Tomography in the Diagnosis of Scleritis and Episcleritis Completed NCT01958567 Not Applicable

Search NIH Clinical Center for Anterior Scleritis

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Genetic Tests for Anterior Scleritis

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Anatomical Context for Anterior Scleritis

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MalaCards organs/tissues related to Anterior Scleritis:

41
Eye, Lung, T Cells, Bone, B Cells, Thymus, Myeloid
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Publications for Anterior Scleritis

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Articles related to Anterior Scleritis:

(show all 47)
# Title Authors Year
1
Iontophoretic delivery of dexamethasone phosphate for non-infectious, non-necrotising anterior scleritis, dose-finding clinical trial. ( 29666122 )
2018
2
Limbal Stem Cell Deficiency Secondary to Diffuse Non-necrotizing Anterior Scleritis: A Clinicopathological Report. ( 29794824 )
2018
3
Ocular metastasis from breast carcinoma simulating anterior scleritis: a case report. ( 28844204 )
2017
4
Anterior scleritis following intravitreal injections in a patient with rheumatoid arthritis: A case report. ( 29382031 )
2017
5
Indocyanine green angiography in anterior scleritis. ( 28886929 )
2017
6
Anterior Scleritis Associated with Pemphigus Vulgaris. ( 29095065 )
2017
7
Uveitis Specialists and Rheumatologists Select Different Therapies for Idiopathic Non-necrotizing Anterior Scleritis. ( 27744531 )
2016
8
Gevokizumab in the treatment of autoimmune, non-necrotizing, anterior scleritis: Results of a phase I/II clinical trial. ( 27663070 )
2016
9
Subconjunctival sirolimus in the treatment of autoimmune non-necrotizing anterior scleritis: results of a phase I/II clinical trial. ( 25526946 )
2015
10
Anterior segment spectral domain optical coherence tomography imaging of patients with anterior scleritis. ( 26597942 )
2015
11
Flurbiprofen: A Nonselective Cyclooxygenase (COX) Inhibitor for Treatment of Noninfectious, Non-necrotizing Anterior Scleritis. ( 26308394 )
2015
12
Adalimumab-induced remission of anterior scleritis: a very rare late manifestation of Takayasu arteritis. ( 26320134 )
2015
13
Cotrimoxazole as a Treatment for Recurrent Idiopathic Anterior Scleritis: A Single-center Experience in 20 Patients. ( 24432898 )
2014
14
Diffuse anterior scleritis and secondary glaucoma as a manifestation of adult T-cell prolymphocytic leukemia. ( 24977988 )
2014
15
Anterior scleritis and celiac disease: a proposed association. ( 23876049 )
2013
16
Management and outcome of microbial anterior scleritis. ( 21694595 )
2011
17
Resolution of anterior scleritis after periodontal therapy. ( 21769277 )
2011
18
Long-term, multicenter evaluation of subconjunctival injection of triamcinolone for non-necrotizing, noninfectious anterior scleritis. ( 21708408 )
2011
19
Subconjunctival triamcinolone acetonide injection in the treatment of acute noninfectious nonnecrotizing anterior scleritis. ( 20510689 )
2010
20
Subconjunctival triamcinolone treatment for non-necrotising anterior scleritis. ( 20447959 )
2010
21
Trabeculectomy with mitomycin C in refractory glaucoma associated with nonnecrotizing anterior scleritis. ( 20001263 )
2009
22
Anterior scleritis as the presenting sign of metastatic lung cancer. ( 18156383 )
2008
23
Optic atrophy, necrotizing anterior scleritis and keratitis presenting in association with Streptococcal Toxic Shock Syndrome: a case report. ( 18312659 )
2008
24
Necrotising anterior scleritis in a late-onset rheumatoid arthritis (LORA) patient. ( 17365805 )
2007
25
Nodular non-necrotising anterior scleritis due to Nocardia nova infection. ( 16878113 )
2007
26
Efficacy of the IL-1 receptor antagonist, anakinra, for the treatment of diffuse anterior scleritis in rheumatoid arthritis. Report of two cases. ( 17449489 )
2007
27
Fungal endophthalmitis complicating subconjunctival injection of triamcinolone acetonide in anterior scleritis. ( 17416964 )
2006
28
Anterior scleritis, scleral thinning, and intraocular pressure measurement. ( 16321890 )
2005
29
Celecoxib, a selective inhibitor of cyclooxygenase 2 for therapy of diffuse anterior scleritis. ( 15953441 )
2005
30
Subconjunctival corticosteroid injection for the treatment of non-necrotising anterior scleritis. ( 15965178 )
2005
31
Successful treatment of refractory anterior scleritis in primary Sjogren's syndrome with rituximab. ( 15958765 )
2005
32
Evaluation of subconjunctival triamcinolone for nonnecrotizing anterior scleritis. ( 16199269 )
2005
33
Therapeutic decision in anterior scleritis: our experience at a tertiary care eye center. ( 16395198 )
2005
34
The diagnosis and management of anterior scleritis. ( 15791166 )
2005
35
Acute febrile neutrophilic dermatosis (Sweet's syndrome) with erythema nodosum and anterior scleritis. A case report. ( 16409276 )
2005
36
Anterior scleritis: three case reports and a review of the literature. ( 15296376 )
2004
37
Bilateral centripetal lipid keratopathy with diffuse anterior scleritis. ( 12752066 )
2003
38
Anterior segment indocyanine green angiography in anterior scleritis and episcleritis. ( 13129874 )
2003
39
Self-inflicted anterior scleritis. ( 12579186 )
2003
40
A prospective evaluation of subconjunctival injection of triamcinolone acetonide for resistant anterior scleritis. ( 11927443 )
2002
41
Nodular anterior scleritis associated with ocular trauma. ( 11465321 )
2001
42
Self-inflicted anterior scleritis. ( 11150288 )
2001
43
Subconjunctival corticosteroid injections for nonnecrotizing anterior scleritis. ( 10408466 )
1999
44
Use of topical steroid therapy in the management of nonnecrotizing anterior scleritis. ( 10396658 )
1999
45
Therapy of nonnecrotizing anterior scleritis with subconjunctival corticosteroid injection. ( 7777270 )
1995
46
Necrotising anterior scleritis after pterygium surgery. ( 7818874 )
1994
47
Diffuse anterior scleritis during OKT3 monoclonal antibody therapy for renal transplant rejection. ( 1555131 )
1992
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Variations for Anterior Scleritis

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Expression for Anterior Scleritis

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Search GEO for disease gene expression data for Anterior Scleritis.
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Pathways for Anterior Scleritis

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Pathways related to Anterior Scleritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 66
Show member pathways
 12.96 B2M IL1RN IL5 NCAM1 PRTN3 TNFRSF1B
2
NF-kappaB Signaling 4
11.95 B2M CD19 IL1RN MPO NCAM1 TNFRSF1B
3
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 66
11.63 B2M CD19 CD22
4
Hematopoietic cell lineage 37
11.44 CD19 CD22 CD5 IL5
5
B Cell Development Pathways 65
11.16 CD19 CD22 CD5
6
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.16 CD19 CD22 CD5 IL5 MPO NCAM1
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GO Terms for Anterior Scleritis

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Cellular components related to Anterior Scleritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.56 B2M CD19 CD22 IL1RN KRT12 KRT19
2 external side of plasma membrane GO:0009897 9.46 B2M CD19 CD5 NCAM1
3 plasma membrane GO:0005886 9.4 B2M CD19 CD22 CD5 IL1RAPL2 IL1RN

Biological processes related to Anterior Scleritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.02 IL1RAPL2 IL1RN IL5 PRTN3 TNFRSF1B
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Sources for Anterior Scleritis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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