MCID: ANT023
MIFTS: 29

Anterior Scleritis

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Anterior Scleritis

MalaCards integrated aliases for Anterior Scleritis:

Name: Anterior Scleritis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:13794
ICD9CM 34 379.03
SNOMED-CT 67 63454000
ICD10 32 H15.01
UMLS 71 C0155353

Summaries for Anterior Scleritis

MalaCards based summary : Anterior Scleritis is related to vasculitis and iridocyclitis. An important gene associated with Anterior Scleritis is IL1RAPL2 (Interleukin 1 Receptor Accessory Protein Like 2), and among its related pathways/superpathways is Interleukin-10 signaling. The drugs Methotrexate and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include eye, lung and breast.

Related Diseases for Anterior Scleritis

Diseases in the Scleritis family:

Posterior Scleritis Anterior Scleritis

Diseases related to Anterior Scleritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)
# Related Disease Score Top Affiliating Genes
1 vasculitis 29.6 TNFRSF1B PRTN3 CRP
2 iridocyclitis 29.4 TNFRSF1B MRAP CRP
3 granulomatosis with polyangiitis 29.4 TNFRSF1B PRTN3 CRP
4 endophthalmitis 29.4 MRAP CRP
5 septic arthritis 29.2 MRAP CRP
6 scleritis 28.8 TNFRSF1B PRTN3 MRAP IL1RN IL1RAPL2 CRP
7 rheumatoid arthritis 28.7 TNFRSF1B PRTN3 IL1RN IL1RAPL2 CRP
8 autoimmune disease 28.6 TNFRSF1B PRTN3 IL1RN IL1RAPL2 CRP
9 scleroperikeratitis 11.5
10 sclerosing keratitis 11.5
11 brawny scleritis 11.4
12 uveitis 10.4
13 systemic onset juvenile idiopathic arthritis 10.2 IL1RN IL1RAPL2
14 wells syndrome 10.2 IL1RAPL2 CRP
15 juvenile arthritis 10.1 IL1RAPL2 CRP
16 ocular hypertension 10.1
17 familial cold autoinflammatory syndrome 10.1 IL1RN IL1RAPL2
18 orbital granuloma 10.1 PRTN3 CRP
19 ethmoid sinusitis 10.1 PRTN3 CRP
20 tolosa-hunt syndrome 10.1 PRTN3 CRP
21 bicipital tenosynovitis 10.1 PRTN3 CRP
22 multiple cranial nerve palsy 10.1 PRTN3 CRP
23 cranial nerve palsy 10.1 PRTN3 CRP
24 granulomatous angiitis 10.1 PRTN3 CRP
25 glossopharyngeal nerve disease 10.1 PRTN3 CRP
26 cholesterol embolism 10.1 PRTN3 CRP
27 cogan syndrome 10.1 PRTN3 CRP
28 subacute bacterial endocarditis 10.1 PRTN3 CRP
29 hyperglobulinemic purpura 10.1 TNFRSF1B IL1RN
30 splenic infarction 10.1 PRTN3 CRP
31 mastoiditis 10.1 PRTN3 CRP
32 cinca syndrome 10.1 IL1RN IL1RAPL2
33 maxillary sinusitis 10.1 PRTN3 CRP
34 pyuria 10.1 PRTN3 CRP
35 central retinal artery occlusion 10.1 PRTN3 CRP
36 lung abscess 10.1 PRTN3 CRP
37 cryptogenic organizing pneumonia 10.1 PRTN3 CRP
38 autoimmune vasculitis 10.1 PRTN3 CRP
39 tracheal disease 10.1 PRTN3 CRP
40 acute proliferative glomerulonephritis 10.1 PRTN3 CRP
41 rapidly progressive glomerulonephritis 10.0 PRTN3 CRP
42 facial nerve disease 10.0 PRTN3 CRP
43 facial paralysis 10.0 PRTN3 CRP
44 igg4-related disease 10.0 PRTN3 CRP
45 keratitis, hereditary 10.0
46 pemphigus vulgaris, familial 10.0
47 retinal detachment 10.0
48 strabismus 10.0
49 intraocular pressure quantitative trait locus 10.0
50 scleromalacia perforans 10.0

Graphical network of the top 20 diseases related to Anterior Scleritis:



Diseases related to Anterior Scleritis

Symptoms & Phenotypes for Anterior Scleritis

Drugs & Therapeutics for Anterior Scleritis

Drugs for Anterior Scleritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
2
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
3
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
4
Infliximab Approved Phase 3 170277-31-3
5 Gastrointestinal Agents Phase 3
6 Immunologic Factors Phase 3
7 Immunosuppressive Agents Phase 3
8 Alkylating Agents Phase 3
9 Dermatologic Agents Phase 3
10 Antirheumatic Agents Phase 3
11
Clotrimazole Approved, Vet_approved Phase 1, Phase 2 23593-75-1 2812
12
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
13
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
14 Anti-Infective Agents Phase 1, Phase 2
15 Anti-Bacterial Agents Phase 1, Phase 2
16 Antifungal Agents Phase 1, Phase 2
17 Antibiotics, Antitubercular Phase 1, Phase 2
18 Hormones Phase 2
19 Hormone Antagonists Phase 2
20 Adrenocorticotropic Hormone Phase 2
21 Endorphins Phase 2
22 Neurotransmitter Agents Phase 2
23 Melanocyte-Stimulating Hormones Phase 2
24 beta-Endorphin Phase 2
25
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
26
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
27 Antineoplastic Agents, Hormonal Phase 1
28 Pharmaceutical Solutions Phase 1
29 Ophthalmic Solutions Phase 1
30 Antiemetics Phase 1
31
protease inhibitors Phase 1
32 HIV Protease Inhibitors Phase 1
33 Dexamethasone 21-phosphate Phase 1
34 glucocorticoids Phase 1
35 BB 1101 Phase 1
36 Anti-Inflammatory Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multicenter Randomized Open-label Trial Comparing the Efficacy and Safety of Infliximab Versus Cyclophosphamide in Subjects With Idiopathic Refractory Scleritis Not yet recruiting NCT03088293 Phase 3 Infliximab;Cyclophosphamide
2 Gevokizumab Treatment for Active Scleritis By IL-1 Inhibition (GATSBY) Completed NCT01835132 Phase 1, Phase 2
3 A Phase I/II Study to Investigate Subconjunctival Sirolimus for the Treatment of Active Autoimmune Non-Necrotizing Anterior Scleritis Completed NCT01517074 Phase 1, Phase 2 Sirolimus
4 An Open Label, Multi-centered, Randomized Phase 2 Study to Evaluate the Safety, Tolerability and Bioactivity of Subcutaneous ACTH GeL in PAtients With Scleritis: The ATLAS Study Recruiting NCT03465111 Phase 2 ACTH (adrenocorticotropic hormone) gel
5 Iontophoresis Delivery of Dexamethasone Phosphate for Non-infectious, Non-necrotizing Anterior Scleritis, Phase 1 Dose-varying Study Completed NCT01059955 Phase 1 Dexamethasone Phosphate Ophthalmic Solution (EGP-437);Dexamethasone phosphate ophthalmic solution
6 Optical Coherence Tomography in the Diagnosis of Scleritis and Episcleritis Completed NCT01958567

Search NIH Clinical Center for Anterior Scleritis

Genetic Tests for Anterior Scleritis

Anatomical Context for Anterior Scleritis

MalaCards organs/tissues related to Anterior Scleritis:

40
Eye, Lung, Breast, T Cells, Neutrophil, B Cells, Endothelial

Publications for Anterior Scleritis

Articles related to Anterior Scleritis:

(show top 50) (show all 150)
# Title Authors PMID Year
1
Cataract Surgery in the Setting of Scleritis. 61
32463347 2020
2
Experience With 0.1% Tacrolimus Eye Drop for Noninfectious, Non-necrotizing Anterior Scleritis. 61
32404650 2020
3
Clinical Profile of Patients with Scleritis in Bangladesh. 61
32130057 2020
4
Eye metastasis in lung adenocarcinoma mimicking anterior scleritis: A case report. 61
32047793 2020
5
Necrotic scleral melt and fungal keratitis-a complication of subtenon triamcinolone acetonide injection. 61
31984430 2020
6
Clinical Features, Treatment, and Visual Outcomes of Japanese Patients with Posterior Scleritis. 61
30806525 2020
7
Nodular Scleritis Revealing Metastasis of Breast Cancer: Diagnosis Not to Be Neglected. 61
32082666 2020
8
Frequently Relapsing Anterior Nodular Scleritis as the Initial Presentation of a Lethal Systemic Infection: Disseminated Tuberculosis with HIV Coinfection. 61
32082660 2020
9
Pseudomonas aeruginosa scleritis initially presenting as idiopathic diffuse anterior scleritis. 61
32174745 2020
10
Tuberculous scleritis in a young Asian Indian girl-a case presentation and literature review. 61
31872314 2019
11
Anterior Scleritis in a Patient of Pemphigus Vulgaris while on Immunosuppressive Treatment. 61
31896853 2019
12
Clinical characteristics of scleritis patients with emphasized comparison of associated systemic diseases (anti-neutrophil cytoplasmic antibody-associated vasculitis and rheumatoid arthritis). 61
31183624 2019
13
Known and novel ocular toxicities of biologics, targeted agents, and traditional chemotherapeutics. 61
31098752 2019
14
Aspergillus Flavus Necrotising Scleritis following Pars Plana Vitrectomy. 61
31429609 2019
15
Remission Of Non-Infectious Anterior Scleritis: Incidence And Predictive Factors. 61
30951689 2019
16
Pattern of Scleritis in an Egyptian Cohort. 61
30412434 2019
17
Co-occurrence of bilateral nodular anterior scleritis and large-vessel arteritis in a patient with TINU syndrome. 61
31728261 2019
18
Clinical Characteristics of Ocular Sarcoidosis: A Population-Based Study 1976-2013. 61
29023165 2019
19
New onset or exacerbation of uveitis with infliximab: paradoxical effects? 61
31355342 2019
20
Anterior Scleritis Associated with Pemphigus Vulgaris. 61
29095065 2019
21
The clinical features of posterior scleritis with serous retinal detachment: a retrospective clinical analysis. 61
31341807 2019
22
Clinical Profile of Scleritis in Children. 61
29370565 2019
23
Antineutrophil cytoplasmic antibody-positive scleritis: Clinical profile of patients from a tuberculosis-endemic region. 61
30355867 2018
24
[Scleritis and systemic diseases: What should know the internist?] 61
29496270 2018
25
Limbal Stem Cell Deficiency Secondary to Diffuse Non-necrotizing Anterior Scleritis: A Clinicopathological Report. 61
29794824 2018
26
Clinical profile of patients with posterior scleritis: A report from Eastern India. 61
30038152 2018
27
Iontophoretic delivery of dexamethasone phosphate for non-infectious, non-necrotising anterior scleritis, dose-finding clinical trial. 61
29666122 2018
28
Indocyanine green angiography in anterior scleritis. 61
28886929 2018
29
Clinical Features and Complications of Scleritis in Chinese Patients. 61
27849414 2018
30
Patch Grafting Using an Ologen Collagen Matrix to Manage Tubal Exposure in Glaucoma Tube Shunt Surgery. 61
29643776 2018
31
Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS)-report 4: analysis and outcome of scleritis in an East Asian population. 61
28205148 2017
32
Anterior scleritis following intravitreal injections in a patient with rheumatoid arthritis: A case report. 61
29382031 2017
33
Ocular metastasis from breast carcinoma simulating anterior scleritis: a case report. 61
28844204 2017
34
Scleritis and Takayasu's disease - rare combined presentation. 61
29634707 2017
35
An OCT Study of Anterior Nodular Episcleritis and Scleritis. 61
28348907 2017
36
Uveitis Specialists and Rheumatologists Select Different Therapies for Idiopathic Non-necrotizing Anterior Scleritis. 61
27744531 2016
37
Gevokizumab in the Treatment of Autoimmune Non-necrotizing Anterior Scleritis: Results of a Phase I/II Clinical Trial. 61
27663070 2016
38
High-resolution ultrasound biomicroscopy as an adjunctive diagnostic tool for anterior scleral inflammatory disease. 61
26892270 2016
39
Anterior segment spectral domain optical coherence tomography imaging of patients with anterior scleritis. 61
26597942 2016
40
Isolated posterior scleritis associated with tuberculosis. 61
27224075 2016
41
Clinical and laboratory characteristics of ocular syphilis, co-infection, and therapy response. 61
26730177 2016
42
Flurbiprofen: A Nonselective Cyclooxygenase (COX) Inhibitor for Treatment of Noninfectious, Non-necrotizing Anterior Scleritis. 61
26308394 2016
43
Anterior tuberculous scleritis: A diagnostic challenge. 61
25817957 2015
44
Rituximab in the treatment of refractory scleritis in patients with granulomatosis with polyangiitis (Wegener's). 61
26507398 2015
45
Adalimumab-induced remission of anterior scleritis: a very rare late manifestation of Takayasu arteritis. 61
26320134 2015
46
Ophthalmological implications of the chronic infections with the hepatitis C Virus. 61
29450318 2015
47
Optical coherence tomography in the diagnosis of scleritis and episcleritis. 61
25771347 2015
48
Cotrimoxazole as a Treatment for Recurrent Idiopathic Anterior Scleritis: A Single-center Experience in 20 Patients. 61
24432898 2015
49
Use of multiple immunosuppressive agents in recalcitrant ACANTHAMOEBA scleritis. 61
25878227 2015
50
Subconjunctival sirolimus in the treatment of autoimmune non-necrotizing anterior scleritis: results of a phase I/II clinical trial. 61
25526946 2015

Variations for Anterior Scleritis

Expression for Anterior Scleritis

Search GEO for disease gene expression data for Anterior Scleritis.

Pathways for Anterior Scleritis

Pathways related to Anterior Scleritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.31 TNFRSF1B IL1RN

GO Terms for Anterior Scleritis

Biological processes related to Anterior Scleritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 8.92 TNFRSF1B PRTN3 IL1RN IL1RAPL2

Sources for Anterior Scleritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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