Anterior Uveitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ANT034 MIFTS: 54	Anterior Uveitis Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Anterior Uveitis

MalaCards integrated aliases for Anterior Uveitis:

Name: Anterior Uveitis ⁵⁴ ¹⁷ ⁷⁴

Iridocyclitis ⁵⁴ ⁷⁴

Acute Anterior Uveitis ⁷⁴

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases Neuronal diseases Immune diseases

See all MalaCards categories (disease lists)

External Ids:

EFO ¹⁷ EFO_1000811

UMLS ⁷⁴ C0022073 C0042165 C0701807

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Summaries for Anterior Uveitis

MalaCards based summary : Anterior Uveitis, also known as iridocyclitis, is related to spondylitis and spondyloarthropathy 1. An important gene associated with Anterior Uveitis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Adalimumab and Ganciclovir have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and t cells, and related phenotypes are cardiovascular system and hematopoietic system

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Related Diseases for Anterior Uveitis

Diseases in the Uveitis family:

Autoimmune Uveitis	Posterior Uveitis
Intermediate Uveitis	Infectious Anterior Uveitis
Anterior Uveitis	Infectious Posterior Uveitis

Diseases related to Anterior Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 404)

#	Related Disease	Score	Top Affiliating Genes
1	spondylitis	31.0	HLA-B IL6 TNF
2	spondyloarthropathy 1	31.0	HLA-B TLR4 TNF
3	arthritis	30.5	IL6 PTPN22 TNF
4	choroiditis	30.3	CFH TNF
5	pars planitis	30.2	HLA-A HLA-B
6	localized scleroderma	30.1	IL6 TNF
7	joint disorders	30.1	IL6 TNF
8	stromal keratitis	30.1	IL6 TNF
9	rubella	30.1	HLA-A HLA-B TNF
10	tuberculous meningitis	30.0	TLR2 TNF
11	multifocal choroiditis	30.0	CFH TNF
12	colitis	29.9	IL6 TLR4 TNF
13	vasculitis	29.9	CFI HLA-B TNF
14	cysticercosis	29.9	IL6 TLR4
15	cytomegalovirus retinitis	29.9	HLA-A HLA-B TNF
16	ulcerative colitis	29.8	IL6 TLR4 TNF
17	intermediate uveitis	29.8	HLA-B IL6 TNF
18	mycoplasma pneumoniae pneumonia	29.8	IL6 TLR2 TNF
19	toxoplasmosis	29.8	IL6 TLR2 TLR4 TNF
20	mycobacterium abscessus	29.7	TLR2 TNF
21	acquired immunodeficiency syndrome	29.7	HLA-B IL6 TNF
22	glaucomatocyclitic crisis	29.7	HLA-A HLA-B TNF
23	spondyloarthropathy	29.7	HLA-A HLA-B IL6 TNF
24	panuveitis	29.6	HLA-A HLA-B TNF
25	peritonitis	29.6	IL6 TLR2 TNF
26	pneumonia	29.6	IL6 TLR2 TLR4 TNF
27	leishmaniasis	29.6	TLR2 TLR4 TNF
28	inflammatory bowel disease	29.6	IL6 TLR2 TLR4 TNF
29	leptospirosis	29.6	IL6 TLR2 TNF
30	bacterial meningitis	29.6	IL6 TLR2 TNF
31	meningitis	29.6	IL6 TLR2 TNF
32	trypanosomiasis	29.5	IL6 TLR2 TNF
33	temporal arteritis	29.5	IL6 PTPN22 TNF
34	chlamydia	29.5	IL6 TLR2 TLR4 TNF
35	vogt-koyanagi-harada disease	29.5	HLA-A HLA-B PTPN22
36	common variable immunodeficiency	29.5	IL6 TLR2 TNF
37	cytomegalovirus infection	29.3	HLA-A HLA-B IL6 TNF
38	graft-versus-host disease	29.3	HLA-A HLA-B IL6 TNF
39	q fever	29.3	IL6 TLR2 TLR4 TNF
40	psoriatic arthritis	29.2	HLA-B IL6 PTPN22 TNF
41	diabetes mellitus	29.0	HLA-A HLA-B IL6 PTPN22 TNF
42	rheumatoid arthritis	29.0	HLA-B IL6 PTPN22 TLR2 TLR4 TNF
43	systemic lupus erythematosus	28.7	IL6 PTPN22 TLR2 TLR4 TNF
44	infectious anterior uveitis	12.4
45	idiopathic anterior uveitis	12.4
46	fuchs' heterochromic uveitis	12.3
47	lens-induced iridocyclitis	12.2
48	gonococcal iridocyclitis	12.1
49	phacoanaphylactic uveitis	11.6
50	uveitis	11.2

Graphical network of the top 20 diseases related to Anterior Uveitis:

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Symptoms & Phenotypes for Anterior Uveitis

MGI Mouse Phenotypes related to Anterior Uveitis:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.85	CFH IL6 PTPN22 TLR2 TLR4 TNF
2	hematopoietic system	MP:0005397	9.8	CFH CFI IL6 PTPN22 TLR2 TLR4
3	digestive/alimentary	MP:0005381	9.72	IL6 PTPN22 TLR2 TLR4 TNF
4	liver/biliary system	MP:0005370	9.55	IL6 PTPN22 TLR2 TLR4 TNF
5	renal/urinary system	MP:0005367	9.43	CFH CFI IL6 PTPN22 TLR2 TLR4
6	respiratory system	MP:0005388	9.02	IL6 PTPN22 TLR2 TLR4 TNF

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Drugs & Therapeutics for Anterior Uveitis

Drugs for Anterior Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 119)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Adalimumab

Approved

Phase 4,Phase 3

331731-18-1

16219006

Ganciclovir

Approved, Investigational

Phase 4,Phase 2,Phase 3,Not Applicable

82410-32-0

3454

Acyclovir

Approved

Phase 4,Phase 3

59277-89-3

2022

Methylprednisolone hemisuccinate

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

2921-57-5

Methylprednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

83-43-2

6741

Prednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

50-24-8

5755

Prednisolone phosphate

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

302-25-0

leucovorin

Approved

Phase 4,Phase 1,Not Applicable

58-05-9

6006 143

Methotrexate

Approved

Phase 4,Not Applicable

1959-05-2, 59-05-2

126941

Bimatoprost

Approved, Investigational

Phase 4

155206-00-1

5311027

Dinoprost

Approved, Investigational

Phase 4

551-11-1

5283078

Dinoprost tromethamine

Approved, Vet_approved

Phase 4

38562-01-5

5282415

Difluprednate

Approved

Phase 4,Phase 3,Phase 2

23674-86-4

443936

Certolizumab pegol

Approved

Phase 4,Phase 3

428863-50-7

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 4,Phase 1,Not Applicable

59-30-3

6037

Prednisolone hemisuccinate

Experimental

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

2920-86-7

Hormones

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Anti-Infective Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Anti-Inflammatory Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antirheumatic Agents

Phase 4,Phase 3,Not Applicable

Nucleic Acid Synthesis Inhibitors

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Antiviral Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Ganciclovir triphosphate

Phase 4,Phase 2,Phase 3,Not Applicable

Immunosuppressive Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Immunologic Factors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Methylprednisolone Acetate

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Prednisolone acetate

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Folic Acid Antagonists

Phase 4,Phase 1,Not Applicable

Dermatologic Agents

Phase 4,Phase 3,Not Applicable

Antimetabolites, Antineoplastic

Phase 4,Not Applicable

Folate

Phase 4,Phase 1,Not Applicable

Vitamin B9

Phase 4,Phase 1,Not Applicable

Antimetabolites

Phase 4,Not Applicable

Vitamin B Complex

Phase 4,Phase 1,Not Applicable

beta-endorphin

Phase 4,Not Applicable

Melanocyte-Stimulating Hormones

Phase 4,Not Applicable

Adrenocorticotropic Hormone

Phase 4,Not Applicable

Pharmaceutical Solutions

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antihypertensive Agents

Phase 4

Oxytocics

Phase 4

Benzalkonium Compounds

Phase 4,Phase 3

Lubricant Eye Drops

Phase 4

Ophthalmic Solutions

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Anti-Infective Agents, Local

Phase 4,Phase 3

valacyclovir

Phase 4

Ranibizumab

Approved

Phase 2, Phase 3

347396-82-1

459903

Etanercept

Approved, Investigational

Phase 3,Not Applicable

185243-69-0

Fluprednisolone

Approved

Phase 3,Phase 2

53-34-9

Interventional clinical trials:

(show top 50) (show all 68)

#	Name	Status	NCT ID	Phase	Drugs
1	Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients	Completed	NCT02764697	Phase 4	H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
2	Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study)	Completed	NCT02059655	Phase 4	Bimatoprost;Eye drop solution
3	A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment	Completed	NCT02897115	Phase 4
4	Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis	Recruiting	NCT02943057	Phase 4	2% guttae ganciclovir
5	A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU	Active, not recruiting	NCT03020992	Phase 4	Certolizumab Pegol
6	A Randomized Trial of Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis	Not yet recruiting	NCT03626376	Phase 4	oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily;oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily + topical corticosteroid eye drops
7	Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis	Terminated	NCT02769702	Phase 4	Acthar
8	Methotrexate in the Treatment of Axial Spondyloarthritis	Withdrawn	NCT00298012	Phase 4	Methotrexate
9	Herpetic Eye Disease Study (HEDS) I	Unknown status	NCT00000138	Phase 3	Prednisolone Phosphate;Acyclovir
10	Double-dose Ranibizumab for Polypoidal Choroidal Vasculopathy	Unknown status	NCT02769169	Phase 2, Phase 3	Lucentis® (Raibizumab) double-dose;Lucentis® (Raibizumab) regular-dose
11	Safety and Efficacy of Difluprednate 0.05% for the Treatment of Anterior Uveitis	Completed	NCT01201798	Phase 3	Difluprednate 0.05% ophthalmic emulsion;Prednisolone acetate 1.0% ophthalmic suspension
12	A Multi-center Study to Assess the Efficacy and Safety of LX211 in Active Non-infectious Anterior Uveitis	Completed	NCT00404885	Phase 3	Placebo;LX211;LX211;LX211
13	Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Non-Infectious Anterior Uveitis	Completed	NCT02517619	Phase 3	Dexamethasone Phosphate Ophthalmic Solution;Prednisolone Acetate Ophthalmic (1%)
14	Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis	Completed	NCT00406887	Phase 3	Difluprednate Ophthalmic Emulsion
15	Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis	Completed	NCT01505088	Phase 3	40 mg/mL Dexamethasone phosphate ophthalmic solution;Prednisolone Acetate (1%) Eyedrops;100 mM sodium citrate buffer solution;Placebo Eyedrops
16	Study of Difluprednate Ophthalmic Emulsion in the Treatment of Severe Uveitis	Completed	NCT00407056	Phase 3	Difluprednate Ophthalmic Emulsion
17	Study of Difluprednate in the Treatment of Uveitis	Completed	NCT00501579	Phase 3	Difluprednate;Prednisolone Acetate
18	Herpetic Eye Disease Study (HEDS) II	Completed	NCT00000139	Phase 3	Acyclovir
19	Suprachoroidal Injection of CLS-TA in Subjects Non-infectious Uveitis	Completed	NCT03097315	Phase 3
20	Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis	Completed	NCT02595398	Phase 3	4mg CLS-TA Suprachoriodal Injection;Sham Procedure
21	CLARITY Extension Study	Completed	NCT00641537	Phase 3	Cladribine;Placebo;Cladribine;Cladribine;Placebo
22	A Study of Ixekizumab (LY2439821) in bDMARD-Naive Participants With Radiographic Axial Spondyloarthritis	Completed	NCT02696785	Phase 3	Ixekizumab;Placebo;Adalimumab
23	SOLACE Trial - A Phase 3 Trial in Subjects With Non-infectious Anterior-uveitis.	Recruiting	NCT03131154	Phase 3	ADX-102 Ophthalmic Solution (0.5%);Vehicle of ADX-102 Ophthalmic Solution
24	Treatment Tapering in JIA With Inactive Disease	Recruiting	NCT02840175	Phase 3	etanercept;adalimumab;Abatacept;Tocilizumab
25	A Long Term Extension Study of Ixekizumab (LY2439821) in Participants With Axial Spondyloarthritis	Recruiting	NCT03129100	Phase 3	Ixekizumab;Placebo
26	Multicenter Study Evaluating Certolizumab Pegol Compared to Placebo in Subjects With axSpA Without X-ray Evidence of AS	Active, not recruiting	NCT02552212	Phase 3
27	A Study of Ixekizumab (LY2439821) in Participants With Nonradiographic Axial Spondyloarthritis	Active, not recruiting	NCT02757352	Phase 3	Ixekizumab;Placebo
28	A Study of Ixekizumab (LY2439821) in TNF Inhibitor Experienced Participants With Radiographic Axial Spondyloarthritis	Active, not recruiting	NCT02696798	Phase 3	Ixekizumab;Placebo
29	Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis: Treatment Outcomes	Not yet recruiting	NCT03586284	Phase 2, Phase 3	Valganciclovir Hydrochloride;Ganciclovir Sodium;Placebo Oral Tablet;Topical placebo
30	Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis	Not yet recruiting	NCT03576898	Phase 2, Phase 3	Topical ganciclovir versus oral valganciclovir versus placebo
31	Preventing Extension of Oligoarticular Juvenile Idiopathic Arthritis JIA (Limit-JIA)	Not yet recruiting	NCT03841357	Phase 3	Abatacept Injection
32	A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Anterior Uveitis	Terminated	NCT00333996	Phase 2, Phase 3	Dexamethasone
33	Proof of Concept Study to Evaluate Safety and Efficacy of LME636 in the Treatment of Acute Anterior Uveitis	Completed	NCT02482129	Phase 2	LME636 60 mg/mL ophthalmic solution;Dexamethasone 0.1% ophthalmic solution;LME636 Vehicle
34	A Safety and Efficacy Study of NS2 in Patients With Anterior Uveitis	Completed	NCT02406209	Phase 2	NS2;Prednisolone acetate ophthalmic suspension (1%)
35	Safety and Efficacy Study of DSP-Visulex for the Treatment of Anterior Uveitis	Completed	NCT02309385	Phase 1, Phase 2	8% Dexamethasone Sodium Phosphate - Visulex;15% Dexamethasone Sodium Phosphate - Visulex;Prednisolone Acetate (1%) Eye Drops
36	Exploratory Study on Topical ESBA105 in Acute Anterior Uveitis	Completed	NCT00823173	Phase 2
37	Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis	Completed	NCT00405496	Phase 2	Difluprednate Ophthalmic Emulsion
38	Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis	Completed	NCT00130637	Phase 2	Daclizumab
39	Safety and Efficacy Study of Iontophoresis and Dexamethasone Phosphate to Treat Anterior Uveitis	Completed	NCT00694135	Phase 2	EGP-437 1.6 mA-min at 0.4 with EyeGate® II System;EGP-437 4.8 mA-min at 1.2 mA with EyeGate® II System;EGP-437 10.0 mA-min at 2.5 mA with EyeGate® II System;EGP-437 14.0 mA-min at 3.5 mA with EyeGate® II System
40	Topical Interferon Gamma for Macular Edema Secondary to Uveitis	Completed	NCT01376362	Phase 1, Phase 2	Interferon Gamma-1b
41	Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis	Completed	NCT02255032	Phase 2	4 mg CLS-TA;0.8 mg CLS-TA
42	Safety and Efficacy of AIN457 in Noninfectious Uveitis	Completed	NCT00685399	Phase 2	AIN457;AIN 457;AIN457
43	A Phase I/IIa Study for the Treatment of Uveitis With Iontophoresis	Withdrawn	NCT00499551	Phase 1, Phase 2
44	Subconjunctival Sirolimus for the Treatment of Autoimmune Active Anterior Uveiti	Completed	NCT00876434	Phase 1	Sirolimus
45	Study to Evaluate GSK3052230 in Combination With Paclitaxel and Carboplatin, or Docetaxel or as Single Agent in Subjects With Solid Malignancies and Deregulated Fibroblast Growth Factor (FGF) Pathway Signaling	Completed	NCT01868022	Phase 1	GSK3052230;paclitaxel;carboplatin;docetaxel;pemetrexed;cisplatin
46	Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions	Withdrawn	NCT02042027	Phase 1	Gamunex-C
47	Acute Anterior Uveitis: Psychic Burden and Pain	Unknown status	NCT01156285
48	Clinical Outcomes of Topical Ganciclovir Treatment in Cytomegalovirus Anterior Uveitis	Unknown status	NCT01486693
49	Variations in Retinal Nerve Fiber Layer Thickness During Uncomplicated Anterior and Intermediate Uveitis	Unknown status	NCT02879084
50	Etanercept: Single Blind Control Study in Ocular Manifestations of Behcet's Disease	Unknown status	NCT00931957	Not Applicable	Etanercept, Methotrexate, Prednisolone

Search NIH Clinical Center for Anterior Uveitis

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :

rimexolone

scopolamine

scopolamine hydrobromide

tropicamide

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Genetic Tests for Anterior Uveitis

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Anatomical Context for Anterior Uveitis

MalaCards organs/tissues related to Anterior Uveitis:

⁴²

Eye, Endothelial, T Cells, Thyroid, Prostate, Testes, Neutrophil

Sources

Publications for Anterior Uveitis

Articles related to Anterior Uveitis:

(show top 50) (show all 914)

#	Title	Authors	Year
1	Aqueous Humor Analysis Identifies Higher Branched Chain Amino Acid Metabolism as a Marker for Human Leukocyte Antigen-B27 Acute Anterior Uveitis and Disease Activity. ( 30312576 )	Verhagen FH...Kuiper JJW	2019
2	Aqueous tap and rapid diagnosis of cytomegalovirus anterior uveitis: the Reggio Emilia experience. ( 30392022 )	De Simone L...Cimino L	2019
3	PD-1 Polymorphisms Are Associated with Susceptibility of Acute Anterior Uveitis in Chinese Population. ( 30540488 )	Li Y...Zheng M	2019
4	Acute anterior uveitis in spondyloarthritis: a monocentric study of 301 patients. ( 30620268 )	Frantz C...Molto A	2019
5	BISPHOSPHONATE-INDUCED BILATERAL ANTERIOR UVEITIS AND CHOROIDAL EFFUSIONS WITH SECONDARY ANGLE CLOSURE. ( 30640817 )	Thng ZX...Gan NY	2019
6	Chronic Anterior Uveitis in a Patient with CREST Syndrome. ( 30691950 )	Fuente Cos?o S...Sampedro L?pez A	2019
7	Inhibitory role of transforming growth factor β2 in experimental autoimmune anterior uveitis. ( 30719689 )	Matta B...Bora NS	2019
8	Efficacy of anti-tumour necrosis factor-α monoclonal antibodies in patients with non-infectious anterior uveitis. ( 30719968 )	Fabiani C...Cantarini L	2019
9	Emerging Viral Infections Causing Anterior Uveitis. ( 30794475 )	Khairallah M...Cunningham ET	2019
10	Risk factors associated with persistent anterior uveitis after cataract surgery. ( 30794788 )	Reddy AK...Pantcheva MB	2019
11	Preventive effects of tyrosol, a natural phenolic compound, on anterior uveitis induced by anterior chamber paracentesis in healthy beagle dogs. ( 30799325 )	Sato K...Tajima K	2019
12	Evaluation of choroidal parameters in eyes at the first onset of acute anterior uveitis. ( 30819128 )	Wi?cek MP...Machali?ska A	2019
13	Novel gene targets for miRNA146a and miRNA155 in anterior uveitis. ( 30297336 )	O'Rourke M...Murphy CC	2019
14	Inflammatory bowel disease and acute anterior uveitis, but not psoriasis are associated with disease duration in Axial SpA: results from the (Be)Giant and ASPECT cohort. ( 29740978 )	Varkas G....Elewaut D.	2018
15	Diagnosis of Cytomegalovirus Anterior Uveitis in Two European Referral Centers. ( 29377783 )	Relvas L.J.M....Caspers L.	2018
16	The pathogenic role of dendritic cells in non-infectious anterior uveitis. ( 29763582 )	O'Rourke M....Canavan M.	2018
17	Increased Circulating Proinflammatory T Lymphocytes in Children with Different Forms of Anterior Uveitis: Results from a Pilot Study. ( 29771573 )	Walscheid K....Foell D.	2018
18	Recurrent anterior uveitis and subsequent incidence of ankylosing spondylitis: a nationwide cohort study from 2002 to 2013. ( 29415753 )	Oh B.L....Yu H.G.	2018
19	A study of the key genes and inflammatory signaling pathways involved in HLA-B27-associated acute anterior uveitis families. ( 29620146 )	Yu S....Lu H.	2018
20	Clinical Characteristics of Herpes Simplex Virus Associated Anterior Uveitis. ( 29345511 )	Wensing B....de Boer J.H.	2018
21	Elevated interleukin 37 expression associated with disease activity in HLA-B27 associated anterior uveitis and idiopathic anterior uveitis. ( 29424310 )	Zhao B....Chen L.	2018
22	Childhood Arthritis and Rheumatology Research Alliance consensus treatment plans for juvenile idiopathic arthritis-associated and idiopathic chronic anterior uveitis. ( 29806733 )	Angeles-Han S.T....Rabinovich C.E.	2018
23	Association of IL33 and IL1RAP polymorphisms with acute anterior uveitis. ( 29424312 )	Huang X.F....Wang Y.	2018
24	Clinical Features of CMV-Associated Anterior Uveitis. ( 29172842 )	Chan N.S....Bodaghi B.	2018
25	Immunopathology of Virus-Induced Anterior Uveitis. ( 29543540 )	de Groot-Mijnes J.D.F....Verjans G.M.G.M.	2018
26	Hypertensive acute granulomatous anterior uveitis as a side effect of topical brimonidine. ( 29910082 )	Clemente-TomA!s R....Duch-Samper A.M.	2018
27	Tonic Pupil in Cytomegalovirus Anterior Uveitis in an Immunocompetent Adult Male - A Case Report. ( 29028408 )	Babu K....Sudheer B.	2018
28	Multiplex Cytokine Analysis of Aqueous Humor in Juvenile Idiopathic Arthritis-Associated Anterior Uveitis With or Without Secondary Glaucoma. ( 29675026 )	Bauer D....Heinz C.	2018
29	Prevalence of axial spondyloarthritis in patients with acute anterior uveitis: a cross-sectional study utilising MRI. ( 29531779 )	Sykes M.P....Gaffney K.	2018
30	PCR Multiplex for CMV Detection in Patients with Anterior Uveitis. ( 29474137 )	MartA-n RamA-rez A....GonzA!lez Guijarro J.J.	2018
31	Gut Microbiota Composition and Fecal Metabolic Phenotype in Patients With Acute Anterior Uveitis. ( 29625474 )	Huang X....Yang P.	2018
32	Immunohistochemical characterization of feline lymphoplasmacytic anterior uveitis. ( 29517855 )	Crossfield L....Garden O.A.	2018
33	Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis. ( 29511745 )	Gonzales J.A....Acharya N.R.	2018
34	Spondyloarthritis, Acute Anterior Uveitis, and Fungi: Updating the Catterall-King Hypothesis. ( 29675414 )	Laurence M....Rosenbaum J.T.	2018
35	Clinical features of patients with diabetic anterior uveitis. ( 29563110 )	Watanabe T....Okada A.A.	2018
36	Syphilis-Related Eye Disease Presenting as Bilateral Papilledema, Retinal Nerve Fiber Layer Hemorrhage, and Anterior Uveitis in a Penicillin-Allergic Patient. ( 29670780 )	Dietze J....Havens S.	2018
37	Raised intracranial pressure with bilateral anterior uveitis. ( 29891509 )	Yip I.Y.M....Scotcher S.	2018
38	Chronic Anterior Uveitis in Children: Psychosocial Challenges for Patients and Their Families. ( 29601821 )	Parker D.M....Holland G.N.	2018
39	Differential Diagnosis of Viral-Induced Anterior Uveitis. ( 29869892 )	Relvas L.J....Willermain F.	2018
40	Anterior uveitis. ( 29290458 )	Gueudry J....Muraine M.	2018
41	Virus-Induced Anterior Uveitis (VIAU) in Immunocompromised Patients. ( 29969370 )	de-la-Torre A.	2018
42	The microbiome and HLA-B27-associated acute anterior uveitis. ( 30301938 )	Rosenbaum JT...Asquith M	2018
43	Herpetic Anterior Uveitis - Analysis of Presumed and PCR Proven Cases. ( 30311824 )	Neumann R...Habot-Wilner Z	2018
44	Discovery of tear biomarkers in children with chronic non-infectious anterior uveitis: a pilot study. ( 30327966 )	Angeles-Han ST...Holland GN	2018
45	Demystifying viral anterior uveitis: a review. ( 30345620 )	Chan NS...Chee SP	2018
46	Viral disease of the year: Anterior uveitis. ( 30353994 )	Griffiths PD	2018
47	Novel Dexamethasone Sodium Phosphate Treatment (DSP-Visulex) for Noninfectious Anterior Uveitis: A Randomized Phase I/II Clinical Trial. ( 30354530 )	Papangkorn K...Higuchi WI	2018
48	Reduced Occurrence Rate of Acute Anterior Uveitis in Ankylosing Spondylitis Treated with Golimumab - The GO-EASY Study. ( 30385705 )	van Bentum RE...van der Horst-Bruinsma IE	2018
49	The Management of Acute Anterior Uveitis Complicating Spondyloarthritis: Present and Future. ( 30406148 )	Biggioggero M...Favalli EG	2018
50	Timing of infliximab and adalimumab initiation despite methotrexate in children with chronic non-infectious anterior uveitis. ( 30487588 )	McCracken C...Angeles-Han ST	2018

Sources

Genes for Anterior Uveitis

Genes related to Anterior Uveitis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	TLR4	Toll Like Receptor 4	Protein Coding	34.24	Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	17389503 15043537 9744378 (more) 10951140 9501876
2	HLA-B	Major Histocompatibility Complex, Class I, B	Protein Coding	17.97	GeneCards inferred via : Publications (show sections)
3	CFH	Complement Factor H	Protein Coding	17.27	GeneCards inferred via : Publications (show sections)
4	IL6	Interleukin 6	Protein Coding	17.27	GeneCards inferred via : Publications (show sections)
5	TNF	Tumor Necrosis Factor	Protein Coding	17.07	GeneCards inferred via : Publications (show sections)
6	TLR2	Toll Like Receptor 2	Protein Coding	17.07	GeneCards inferred via : Publications (show sections)
7	PTPN22	Protein Tyrosine Phosphatase Non-Receptor Type 22	Protein Coding	17.07	GeneCards inferred via : Publications (show sections)
8	CFI	Complement Factor I	Protein Coding	17.07	GeneCards inferred via : Publications (show sections)
9	HLA-A	Major Histocompatibility Complex, Class I, A	Protein Coding	17.07	GeneCards inferred via : Publications (show sections)

Sources

Variations for Anterior Uveitis

Sources

Expression for Anterior Uveitis

Search GEO for disease gene expression data for Anterior Uveitis.

Sources

Pathways for Anterior Uveitis

Pathways related to Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 40)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁷ Show member pathways Immune System ⁶⁷ Neutrophil degranulation ⁶⁷	13.65	CFH CFI HLA-A HLA-B IL6 PTPN22
2	Class I MHC mediated antigen processing and presentation ⁶⁷ Show member pathways Adaptive Immune System ⁶⁷ Antigen processing- Ubiquitination and Proteasome degradation ⁶⁷	13.26	HLA-A HLA-B PTPN22 TLR2 TLR4
3	Toll-like Receptor Signaling Pathway ³⁸ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁸ Epstein-Barr virus infection ³⁸ Hepatitis B ³⁸ Hepatitis C ³⁸ NOD-like Receptor Signaling Pathways ⁶⁶ Regulation of toll-like receptor signaling pathway ¹	13	IL6 TLR2 TLR4 TNF
4	Allograft rejection ¹ ³⁸ Show member pathways Antigen processing and presentation ³⁸ Asthma ³⁸ Autoimmune thyroid disease ³⁸ CTL Mediated Apoptosis ⁶⁵ Graft-versus-host disease ³⁸ Intestinal immune network for IgA production ³⁸ THC Differentiation Pathway ⁶⁵ Type I diabetes mellitus ³⁸ Viral myocarditis ³⁸	12.7	HLA-A HLA-B IL6 TNF
5	Human cytomegalovirus infection ³⁸ Show member pathways Human immunodeficiency virus 1 infection ³⁸ Kaposi sarcoma-associated herpesvirus infection ³⁸	12.7	HLA-A HLA-B IL6 TLR2 TLR4 TNF
6	PI3K-Akt signaling pathway ³⁸ Show member pathways Human papillomavirus infection ³⁸	12.68	HLA-A HLA-B IL6 TLR2 TLR4 TNF
7	NF-KappaB Family Pathway ⁶⁵ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁵	12.53	IL6 TLR2 TLR4 TNF
8	Th17 cell differentiation ³⁸ Show member pathways IL-22 Pathway ⁶⁵ Immune response IL-22 signaling pathway ²³ Inflammatory bowel disease (IBD) ³⁸ Th1 and Th2 cell differentiation ³⁸	12.44	IL6 TLR2 TLR4 TNF
9	Antigen processing-Cross presentation ⁶⁷ Show member pathways Cross-presentation of particulate exogenous antigens (phagosomes) ⁶⁷ Endosomal/Vacuolar pathway ⁶⁷ ER-Phagosome pathway ⁶⁷ Immune response Antigen presentation by MHC class I ²³	12.33	HLA-A HLA-B TLR2 TLR4
10	Human T-cell leukemia virus 1 infection ³⁸	12.22	HLA-A HLA-B IL6 TNF
11	IL-17 Family Signaling Pathways ⁶⁶ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁸ Interleukin-17 signaling ⁶⁷ Mucin expression in CF via IL-6, IL-17 signaling pathways ²³	12.17	IL6 TLR2 TNF
12	Toll Comparative Pathway ⁶⁵ Show member pathways IL-1 Pathway ⁶⁵ Immune response MIF in innate immunity response ²³ iNOS Signaling ⁶⁵ TLR-TRIF Pathway ⁶⁵	12.15	IL6 TLR4 TNF
13	Diseases associated with the TLR signaling cascade ⁶⁷ Show member pathways Diseases of Immune System ⁶⁷ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁷ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁷ IRAK4 deficiency (TLR2/4) ⁶⁷ IRAK4 deficiency (TLR5) ⁶⁷ MyD88 deficiency (TLR2/4) ⁶⁷ MyD88 deficiency (TLR5) ⁶⁷ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	12.14	IL6 TLR2 TLR4 TNF
14	Proteoglycans in cancer ³⁸	12.13	TLR2 TLR4 TNF
15	Immune response IFN alpha/beta signaling pathway ²³ Show member pathways Cytokine Network ⁶⁵ Interferon alpha/beta signaling ⁶⁷ Regulation of IFNA signaling ⁶⁷	12.11	HLA-A HLA-B IL6 TNF
16	Influenza A ³⁸ Show member pathways Measles ³⁸	12.11	HLA-A HLA-B IL6 TLR2 TLR4 TNF
17	Tuberculosis ³⁸	12.1	IL6 TLR2 TLR4 TNF
18	Toxoplasmosis ³⁸ Show member pathways Leishmaniasis ³⁸	12.09	TLR2 TLR4 TNF
19	IL-1 Family Signaling Pathways ⁶⁶ Show member pathways Immune response IL-1 signaling pathway ²³ Mucin expression in CF via TLRs, EGFR signaling pathways ²³	12.05	IL6 TLR2 TNF
20	Bacterial infections in CF airways ²³ Show member pathways IL-1 beta-dependent CFTR expression ²³ Immune response Bacterial infections in normal airways ²³ Immune response TLR signaling pathways ²³	12.04	IL6 TLR2 TLR4 TNF
21	Colorectal Cancer Metastasis ⁶⁵	12.03	IL6 TLR2 TLR4 TNF
22	Cellular senescence (KEGG) ³⁸	12.01	HLA-A HLA-B IL6
23	Phagosome ³⁸	11.98	HLA-A HLA-B TLR2 TLR4
24	Th1 Differentiation Pathway ⁶⁶ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁶	11.89	IL6 TLR2 TLR4 TNF
25	Spinal Cord Injury ¹	11.87	IL6 TLR4 TNF
26	Microglia Activation During Neuroinflammation: Overview ⁶⁶ Show member pathways Microglia Activation During Neuroinflammation: Microglia Activation ⁶⁶	11.86	IL6 TLR2 TLR4 TNF
27	Pertussis ³⁸	11.65	IL6 TLR4 TNF
28	Amoebiasis ³⁸	11.6	IL6 TLR2 TLR4 TNF
29	Rheumatoid arthritis ³⁸	11.52	IL6 TLR2 TLR4 TNF
30	MSP-RON Signaling ⁶⁵	11.42	TLR2 TLR4 TNF
31	IL-10 Pathway ⁶⁵	11.26	IL6 TLR4 TNF
32	African trypanosomiasis ³⁸	11.24	IL6 TNF
33	Development and heterogeneity of the ILC family ¹	11.17	IL6 TNF
34	Antifolate resistance ³⁸	11.16	IL6 TNF
35	Cytokines and Inflammatory Response ¹	11.12	IL6 TNF
36	Antigen Presentation- Folding, assembly and peptide loading of class I MHC ⁶⁷	11.04	HLA-A HLA-B
37	Legionellosis ³⁸	11	IL6 TLR2 TLR4 TNF
38	Transcription factor regulation in adipogenesis ¹	10.98	IL6 TNF
39	Overview of nanoparticle effects ¹	10.9	IL6 TNF
40	Malaria ³⁸	10.61	IL6 TLR2 TLR4 TNF

Sources

GO Terms for Anterior Uveitis

Cellular components related to Anterior Uveitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.72	HLA-A HLA-B TLR2 TLR4 TNF
2	intrinsic component of plasma membrane	GO:0031226	9.37	TLR2 TLR4
3	integral component of lumenal side of endoplasmic reticulum membrane	GO:0071556	9.26	HLA-A HLA-B
4	MHC class I protein complex	GO:0042612	9.16	HLA-A HLA-B
5	phagocytic vesicle membrane	GO:0030670	9.13	HLA-A HLA-B TLR2
6	cell surface	GO:0009986	9.02	HLA-A HLA-B TLR2 TLR4 TNF

Biological processes related to Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 39)

#	Name	GO ID	Score	Top Affiliating Genes
1	innate immune response	GO:0045087	9.93	CFH CFI TLR2 TLR4
2	inflammatory response	GO:0006954	9.89	IL6 TLR2 TLR4 TNF
3	immune system process	GO:0002376	9.88	HLA-A HLA-B PTPN22 TLR2 TLR4
4	positive regulation of ERK1 and ERK2 cascade	GO:0070374	9.85	PTPN22 TLR4 TNF
5	response to lipopolysaccharide	GO:0032496	9.81	PTPN22 TLR2 TLR4
6	cellular response to lipopolysaccharide	GO:0071222	9.81	IL6 TLR4 TNF
7	positive regulation of gene expression	GO:0010628	9.8	IL6 PTPN22 TLR2 TLR4 TNF
8	defense response to Gram-positive bacterium	GO:0050830	9.74	IL6 TLR2 TNF
9	immune response	GO:0006955	9.73	HLA-A HLA-B IL6 TLR2 TLR4 TNF
10	positive regulation of inflammatory response	GO:0050729	9.7	TLR2 TLR4 TNF
11	toll-like receptor signaling pathway	GO:0002224	9.68	TLR2 TLR4
12	MyD88-dependent toll-like receptor signaling pathway	GO:0002755	9.67	TLR2 TLR4
13	antigen processing and presentation of peptide antigen via MHC class I	GO:0002474	9.67	HLA-A HLA-B
14	negative regulation of interleukin-6 production	GO:0032715	9.67	TLR4 TNF
15	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.67	IL6 TLR2 TLR4 TNF
16	positive regulation of interferon-beta production	GO:0032728	9.66	TLR2 TLR4
17	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:0002479	9.66	HLA-A HLA-B
18	negative regulation of neurogenesis	GO:0050768	9.65	IL6 TNF
19	positive regulation of interleukin-12 production	GO:0032735	9.65	TLR2 TLR4
20	positive regulation of interleukin-10 production	GO:0032733	9.65	TLR2 TLR4
21	positive regulation of T cell mediated cytotoxicity	GO:0001916	9.64	HLA-A HLA-B
22	positive regulation of NIK/NF-kappaB signaling	GO:1901224	9.63	TLR2 TLR4 TNF
23	microglial cell activation	GO:0001774	9.62	TLR2 TNF
24	positive regulation of glial cell proliferation	GO:0060252	9.62	IL6 TNF
25	positive regulation of nitric-oxide synthase biosynthetic process	GO:0051770	9.61	TLR2 TLR4
26	regulation of cytokine secretion	GO:0050707	9.61	TLR2 TLR4
27	I-kappaB phosphorylation	GO:0007252	9.6	TLR2 TLR4
28	cellular response to lipoteichoic acid	GO:0071223	9.58	TLR2 TLR4
29	positive regulation of interleukin-8 biosynthetic process	GO:0045416	9.58	TLR4 TNF
30	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	GO:0002480	9.56	HLA-A HLA-B
31	negative regulation of lipid storage	GO:0010888	9.55	IL6 TNF
32	antigen processing and presentation of endogenous peptide antigen via MHC class Ib	GO:0002476	9.54	HLA-A HLA-B
33	positive regulation of neuroinflammatory response	GO:0150078	9.51	IL6 TNF
34	positive regulation of interleukin-8 production	GO:0032757	9.5	TLR2 TLR4 TNF
35	protection from natural killer cell mediated cytotoxicity	GO:0042270	9.49	HLA-A HLA-B
36	positive regulation of interleukin-6 production	GO:0032755	9.46	IL6 TLR2 TLR4 TNF
37	positive regulation of cellular response to macrophage colony-stimulating factor stimulus	GO:1903974	9.43	TLR2 TLR4
38	lipopolysaccharide-mediated signaling pathway	GO:0031663	9.26	PTPN22 TLR2 TLR4 TNF
39	positive regulation of chemokine production	GO:0032722	8.92	IL6 TLR2 TLR4 TNF

Molecular functions related to Anterior Uveitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lipopolysaccharide binding	GO:0001530	9.16	TLR2 TLR4
2	peptide antigen binding	GO:0042605	8.96	HLA-A HLA-B
3	lipopolysaccharide receptor activity	GO:0001875	8.62	TLR2 TLR4

Sources

Sources for Anterior Uveitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia

Anterior Uveitis

Aliases & Classifications for Anterior Uveitis

MalaCards integrated aliases for Anterior Uveitis:

Classifications:

External Ids:

Summaries for Anterior Uveitis

Related Diseases for Anterior Uveitis

Diseases in the Uveitis family:

Diseases related to Anterior Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Anterior Uveitis:

Symptoms & Phenotypes for Anterior Uveitis

MGI Mouse Phenotypes related to Anterior Uveitis:

Drugs & Therapeutics for Anterior Uveitis

Drugs for Anterior Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 74 / NDF-RT 52 :

Genetic Tests for Anterior Uveitis

Anatomical Context for Anterior Uveitis

MalaCards organs/tissues related to Anterior Uveitis:

Publications for Anterior Uveitis

Articles related to Anterior Uveitis:

Genes for Anterior Uveitis

Genes related to Anterior Uveitis (0 elite genes):

Variations for Anterior Uveitis

Expression for Anterior Uveitis

Pathways for Anterior Uveitis

Pathways related to Anterior Uveitis according to GeneCards Suite gene sharing:

GO Terms for Anterior Uveitis

Cellular components related to Anterior Uveitis according to GeneCards Suite gene sharing:

Biological processes related to Anterior Uveitis according to GeneCards Suite gene sharing:

Molecular functions related to Anterior Uveitis according to GeneCards Suite gene sharing:

Sources for Anterior Uveitis

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :