MCID: ANT034
MIFTS: 56

Anterior Uveitis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Anterior Uveitis

MalaCards integrated aliases for Anterior Uveitis:

Name: Anterior Uveitis 11 19 58 14 16 71 33
Iridocyclitis 19 58 71 33
Uveitis, Anterior 75 43
Intraocular Inflammation 33
Acute Anterior Uveitis 71
Anterior Chamber Cell 33
Uveal Inflammation 33
Kerato-Uveitis 33
Uveokeratitis 33
Keratouveitis 33
Keratoiritis 33
Uveitis Nos 33
Cyclitis 33
Iritis 33

Characteristics:


Prevelance:

>1/1000 (Denmark) 58

Age Of Onset:

All ages 58

Classifications:

Orphanet: 58  
Rare eye diseases


External Ids:

Disease Ontology 11 DOID:1407
MeSH 43 D014606
NCIt 49 C35109
SNOMED-CT 68 193500005
UMLS via Orphanet 72 C0022073 C0042165
Orphanet 58 ORPHA280886
UMLS 71 C0022073 C0042165 C0701807

Summaries for Anterior Uveitis

GARD: 19 Inflammation of the anterior uvea comprising the iris, angle structures, and the ciliary body. Manifestations of this disorder include ciliary injection, exudation into the anterior chamber, iris changes, and adhesions between the iris and lens (posterior synechiae). Intraocular pressure may be increased or reduced.

MalaCards based summary: Anterior Uveitis, also known as iridocyclitis, is related to infectious anterior uveitis and glaucomatocyclitic crisis. An important gene associated with Anterior Uveitis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Wikipedia: 75 Uveitis (/ˌjuːvɪaɪtɪs/) is inflammation of the uvea, the pigmented layer of the eye between the inner... more...

Related Diseases for Anterior Uveitis

Diseases in the Uveitis family:

Autoimmune Uveitis Posterior Uveitis
Intermediate Uveitis Anterior Uveitis
Infectious Anterior Uveitis Infectious Posterior Uveitis
Systemic Diseases with Anterior Uveitis Systemic Diseases with Posterior Uveitis

Diseases related to Anterior Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1338)
# Related Disease Score Top Affiliating Genes
1 infectious anterior uveitis 32.7 TNF IL17A
2 glaucomatocyclitic crisis 32.2 MRAP HLA-B
3 uveoparotid fever 32.1 CD4 ACE
4 uveitis 31.9 TNF RBP3 IL6 IL23R IL1B IL17A
5 blau syndrome 31.7 TNF TLR4 TLR2 IL1B IL10
6 sympathetic ophthalmia 31.4 TNF SERPINA3 RBP3 IL17A IL10 CD4
7 posterior uveitis 31.2 TNF RBP3 IL6 IL17A ICOSLG HLA-B
8 fuchs' heterochromic uveitis 31.2 IL6 IL10 ACE
9 macular retinal edema 31.2 TNF IL6 IL1B ACE
10 scleritis 31.2 TNF CRP CCR6
11 pars planitis 31.1 RBP3 HLA-B CCR6 ACE
12 macular dystrophy, dominant cystoid 31.0 TNF RBP3 IL6 ACE
13 conjunctivitis 30.9 TNF TLR4 IL6 IL10 HLA-B
14 herpes zoster 30.9 TLR2 IL10 HLA-B CD8A CD4 CCR6
15 psoriasis 1 30.9 IL23R IL17A CCR6
16 iritis 30.8 TNF RBP3 IL6 IL17A IL10 HLA-B
17 retinal vasculitis 30.8 TNF RBP3 CD4 CCR6 ACE
18 spondylarthropathy 30.8 TNF TLR4 TLR2 CRP
19 reactive arthritis 30.7 TNF MRAP IL17A HLA-B ERAP1 CRP
20 corneal ulcer 30.7 TNF IL6 IL1B
21 arthropathy 30.7 TNF IL6 IL1B CRP CCR6
22 juvenile rheumatoid arthritis 30.7 TNF SERPINA3 IL6 IL1B ICOSLG CRP
23 back pain 30.7 IL6 IL1B IL10 CRP
24 spondylitis 30.6 TNF IL6 IL23R IL1B IL17A IL10
25 rubella 30.6 TNF TLR4 IL6 IL1B IL10 HLA-B
26 relapsing polychondritis 30.6 TNF IL6 CRP CD4
27 posterior scleritis 30.6 TNF CRP ACE
28 ocular tuberculosis 30.6 RBP3 CD4 ACE
29 retinal vascular occlusion 30.5 TNF SERPINA3 IL6 CRP
30 neuroretinitis 30.5 CRP CD4 ACE
31 neuritis 30.5 TNF IL6 IL1B IL10
32 iridocyclitis 30.5 TNF RBP3 MRAP IL6 IL1B IL17A
33 optic papillitis 30.5 TNF RBP3 MRAP CRP CD4 ACE
34 sclerosing keratitis 30.5 RBP3 CRP
35 chikungunya 30.4 TNF IL6 IL1B IL17A CRP
36 endophthalmitis 30.4 TNF TLR2 RBP3 IL6 IL1B CRP
37 cytomegalovirus retinitis 30.4 TNF IL10 HLA-B CD8A CD4
38 toxoplasmosis 30.4 TNF IL6 IL1B IL17A IL10
39 interstitial nephritis 30.3 TNF ICOSLG CRP CD8A CD4 CCR6
40 choroiditis 30.3 TNF RBP3 IL17A IL10 CRP CD4
41 optic neuritis 30.3 TNF IL6 IL1B IL10 HLA-B
42 intermediate uveitis 30.3 TNF RBP3 IL6 IL17A CD4 CCR6
43 iga glomerulonephritis 30.3 IL6 CFHR2 CCR6 ACE
44 osteoarthritis 30.3 TNF IL6 IL1B IL17A CRP
45 keratoconjunctivitis sicca 30.3 TNF ICOSLG CD4 CCR6
46 bowel dysfunction 30.3 TNF IL6 IL1B IL10 CRP ACE
47 mumps 30.3 TNF IL6 IL1B IL10
48 toxocariasis 30.3 IL6 IL10 CRP ACE
49 histiocytosis 30.2 TNF SERPINA3 IL17A CCR6
50 panophthalmitis 30.2 RBP3 CRP CD4

Graphical network of the top 20 diseases related to Anterior Uveitis:



Diseases related to Anterior Uveitis

Symptoms & Phenotypes for Anterior Uveitis

GenomeRNAi Phenotypes related to Anterior Uveitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.17 ACE CCR6 CD4 CD8A CFHR2 CRP
2 no effect GR00402-S-2 10.17 ACE CCR6 CD4 CFHR2 CRP ERAP1

MGI Mouse Phenotypes related to Anterior Uveitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 ACE CCR6 CD4 CRP ERAP1 ICOSLG
2 endocrine/exocrine gland MP:0005379 10.15 ACE CD4 CD8A ERAP1 HLA-B IL10
3 liver/biliary system MP:0005370 10.09 ACE ERAP1 IL10 IL17A IL6 MRAP
4 immune system MP:0005387 10.09 ACE CCR6 CD4 CD8A CRP ERAP1
5 neoplasm MP:0002006 10.08 ACE IL10 IL1B IL23R IL6 TLR2
6 no phenotypic analysis MP:0003012 10 CD4 ERAP1 HLA-B IL10 IL17A IL23R
7 cardiovascular system MP:0005385 10 ACE CCR6 CRP HLA-B IL10 IL1B
8 digestive/alimentary MP:0005381 9.97 CD4 HLA-B IL10 IL17A IL23R IL6
9 hematopoietic system MP:0005397 9.86 ACE CCR6 CD4 CD8A ERAP1 HLA-B
10 integument MP:0010771 9.36 CD4 CD8A IL10 IL17A IL1B IL6

Drugs & Therapeutics for Anterior Uveitis

Drugs for Anterior Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 104)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3 3680
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 3003 5743
3
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5
Tobramycin Approved, Investigational Phase 4 32986-56-4 36294
6
Certolizumab pegol Approved Phase 4 428863-50-7
7
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
8
Latanoprost Approved, Investigational Phase 4 130209-82-4 5311221 5282380
9
Travoprost Approved Phase 4 157283-68-6 5282226
10
Timolol Approved Phase 4 26839-75-8 5478 33624
11
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
12
Adalimumab Approved, Experimental Phase 4 331731-18-1
13
Levoleucovorin Approved, Experimental, Investigational Phase 4 68538-85-2, 58-05-9, 73951-54-9 149436 6006
14
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 4112 126941
15
Fluocinolone acetonide Approved, Investigational, Vet_approved Phase 4 67-73-2 6215
16
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
17
Maleic acid Experimental, Investigational Phase 4 110-16-7, 110-17-8 444266 444972
18
Triamcinolone hexacetonide Phase 4
19
Triamcinolone diacetate Phase 4
20
Triamcinolone Acetonide Phase 4 6436
21 Anesthetics Phase 4
22 Gentamicins Phase 4
23 Pharmaceutical Solutions Phase 4
24 Anticoagulants Phase 4
25 Blood Substitutes Phase 4
26 Adrenergic beta-Antagonists Phase 4
27 Adrenergic Antagonists Phase 4
28 Adrenergic Agents Phase 4
29 Anti-Arrhythmia Agents Phase 4
30 Antihypertensive Agents Phase 4
31 Lubricant Eye Drops Phase 4
32 Plasma Substitutes Phase 4
33 Dextrans Phase 4
34 Immunosuppressive Agents Phase 4
35 Immunologic Factors Phase 4
36 Ophthalmic Solutions Phase 4
37 Antiviral Agents Phase 4
38 Anti-Infective Agents Phase 4
39 Ganciclovir triphosphate Phase 4
40 Folic Acid Antagonists Phase 4
41 Folate Phase 4
42 Vitamin B9 Phase 4
43 Vitamin B Complex Phase 4
44 Antimetabolites Phase 4
45 Melanocyte-Stimulating Hormones Phase 4
46 Adrenocorticotropic Hormone Phase 4
47
beta-Endorphin Phase 4
48
Difluprednate Approved Phase 3 23674-86-4 443936
49
Sodium citrate Approved, Investigational Phase 3 68-04-2 23431961
50
Loteprednol etabonate Approved, Experimental Phase 3 82034-46-6, 129260-79-3 22227703 9865442 444025

Interventional clinical trials:

(show top 50) (show all 67)
# Name Status NCT ID Phase Drugs
1 Evaluation of DEXTENZA on the Management of Pain and Inflammation in Patients With Anterior Uveitis Compared to Standard of Care Topical Corticosteroids Unknown status NCT04426734 Phase 4 Topical Prednisolone Acetate 1%
2 Quantitative Comparison of the Efficacy of Subtenon 20-mg Triamcinolone Injection With 0.1% Dexamethasone Eye Drop in Controlling Intraocular Inflammation After Phacoemulsification Unknown status NCT01801774 Phase 4 Subtenon 20-mg triamcinolone injection;Placebo
3 Multicenter, Open-Label Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis Flares in Axial Spondyloarthritis Subjects With a History of Anterior Uveitis (C-VIEW) Completed NCT03020992 Phase 4 Certolizumab Pegol
4 Prospective Open Label Study of H.P. Acthar Gel Injection in Patients With Active Non-Infectious Uveitis With Associated Glaucoma Thus High Frequency Regional Corticosteroid and Oral Corticosteroids Cause Intolerable Side-Effects Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
5 Blood-aqueous Barrier Changes After the Use of Timolol and Prostaglandin Analogues Fixed Combination in Pseudophakic Patients With Primary Open Angle Glaucoma Completed NCT01978015 Phase 4 travoprost and timolol maleate fixed combination;latanoprost and maleate timolol fixed combination;bimatoprost and timolol maleate fixed combination;dextran and hypromellose
6 Multi-center, Randomized, Double Masked, Vehicle Controlled Phase IV Study to Compare the Efficacy, Ocular Safety and Tolerability of a Two Day Treatment With Eye Drops (0.5% Prednisolone Acetate, One Drop Four Times Per Day) in Patients With Intraocular Inflammation After Cataract Surgery, Followed by an Open Label Observational Period of 12 Days Completed NCT00170729 Phase 4 Prednisolone acetate
7 Intra-cameral Penetration and Efficacy of Ganciclovir Following Topical Administration of 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4 2% guttae ganciclovir
8 The Efficacy and Safety of Adalimumab for Inflammatory Flare Prevention in Non-infectious Anterior Pediatric Uveitis With Peripheral Vascular Leakage Compared With Methotrexate, a RCT Study Recruiting NCT05015335 Phase 4 Adalimumab;Methotrexate
9 Phase 4 Study of YUTIQ® (Fluocinolone Acetonide Intravitreal Implant) 0.18 mg in the Treatment of Chronic Non-Infectious Posterior Segment Uveitis (Intraocular Inflammation Study) Recruiting NCT05322070 Phase 4 Fluocinolone Acetonide Intravitreal Implant 0.18 mg
10 Prospective Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis Who Are Not Well Controlled With, or Intolerant of, Topical or Systemic Corticosteroids Terminated NCT02769702 Phase 4 Acthar
11 Phase 3 Confirmatory Study of 0.05% Difluprednate Ophthalmic Emulsion in the Treatment of Anterior Uveitis (Including Panuveitis). Completed NCT00406887 Phase 3 Difluprednate Ophthalmic Emulsion
12 A Phase 3, Randomized, Double-masked, Vehicle-controlled Trial to Evaluate the Safety and Efficacy of ADX-102 Ophthalmic Solution in Subjects With Non-infectious Anterior-uveitis. Completed NCT03131154 Phase 3 ADX-102 Ophthalmic Solution (0.5%);Vehicle of ADX-102 Ophthalmic Solution
13 A Prospective, Multi-Center, Randomized, Double-Masked, Positive Controlled, Phase 3 Clinical Trial Designed to Evaluate the Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution Compared to Prednisolone Acetate Ophthalmic Suspension (1%) in Patients With Non-Infectious Anterior Segment Uveitis Completed NCT02517619 Phase 3 Dexamethasone Phosphate Ophthalmic Solution;Prednisolone Acetate Ophthalmic (1%)
14 A Phase 3 Multicenter, Randomized, Double-Masked Study of the Safety and Efficacy of Difluprednate 0.05% Ophthalmic Emulsion Compared to Prednisolone Acetate 1% Ophthalmic Suspension in the Treatment of Endogenous Anterior Uveitis Completed NCT01201798 Phase 3 Difluprednate 0.05% ophthalmic emulsion;Prednisolone acetate 1.0% ophthalmic suspension
15 A Prospective, Multi-Center, Randomized, Double-Masked, Positive-Controlled Phase 3 Clinical Trial Designed to Evaluate the Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution Compared to Prednisolone Acetate Ophthalmic Suspension (1%) in Patients With Non-Infectious Anterior Segment Uveitis Completed NCT01505088 Phase 3 40 mg/mL Dexamethasone phosphate ophthalmic solution;Prednisolone Acetate (1%) Eyedrops;100 mM sodium citrate buffer solution;Placebo Eyedrops
16 Phase 3 Open-Labeled Study of 0.05% Difluprednate Ophthalmic Emulsion in the Treatment of Severe Anterior Uveitis (Including Panuveitis). Completed NCT00407056 Phase 3 Difluprednate Ophthalmic Emulsion
17 A Double-Masked, Placebo-Controlled, Parallel-Group, Multi-Center, Dose-Ranging Study With an Optional Extension to Assess the Efficacy and Safety of LX211 as Therapy in Subjects With Active Sight Threatening, Non-infectious Anterior Uveitis Completed NCT00404885 Phase 3 Placebo;LX211
18 A Phase 3, Randomized, Masked, Controlled Clinical Trial to Study the Safety and Efficacy of Triamcinolone Acetonide Injectable Suspension (CLS-TA) for the Treatment of Subjects With Macular Edema Associated With Non-infectious Uveitis Completed NCT02595398 Phase 3 4mg CLS-TA Suprachoriodal Injection;Sham Procedure
19 Open-label Safety Study of Suprachoroidal Triamcinolone Acetonide Injectable Suspension in Patients With Non-Infectious Uveitis Completed NCT03097315 Phase 3 4 mg CLS-TA Suprachoriodal Injection
20 Intravitreal Bevacizumab for the Treatment of Neovascular Membranes in Patients With Intraocular Inflammation Completed NCT00407121 Phase 3 Bevacizumab
21 A Multicenter, Randomized, Double-masked, Vehicle-controlled, Parallel Group Phase III Study of the Efficacy and Safety of a Single Sub-conjunctival Injection of XG-102 for the Reduction of Post-cataract Surgery Intraocular Inflammation Completed NCT02508337 Phase 3 XG-102;Placebo
22 Safety and Efficacy of Topical Loteprednol Etabonate 0.5%, Versus Prednisolone Acetate 1%, for the Treatment of Intraocular Inflammation Following Surgery for Childhood Cataract Completed NCT01475643 Phase 3 Loteprednol etabonate;Prednisolones acetate
23 A Multicenter, Randomized, Double-masked, Vehicle-controlled, Parallel Group Phase III Study of the Efficacy and Safety of a Single Sub-conjunctival Injection of XG-102 for the Reduction of Post-cataract Surgery Intraocular Inflammation Completed NCT02235272 Phase 3 XG-102;Placebo
24 A Phase 3 Randomized, Active-Controlled, Double-Masked Study to Evaluate the Safety and Efficacy of TRS01 Eye Drops in the Treatment of Subjects With Active Non-infectious Anterior Uveitis Including Subjects With Uveitic Glaucoma Recruiting NCT05042609 Phase 3 TRS01;FDA approved steroid eye drop
25 Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis: Treatment Recruiting NCT03586284 Phase 2, Phase 3 Valganciclovir Hydrochloride;Ganciclovir Sodium;Placebo Oral Tablet;Topical placebo
26 Efficacy, Safety and Cost-effectiveness of Methotrexate, Adalimumab, or Their Combination in Non-infectious Non-anterior Uveitis: a Randomized, Parallel 3 Arms, Active-controlled, Phase 3 Open Label With Blinded Outcome Assessment Study Recruiting NCT04798755 Phase 3 Methotrexate;Adalimumab;Adalimumab+Methotrexate
27 The Use of Two YUTIQ Versus Sham for Treatment of Chronic Non Infectious Intraocular Inflammation Affecting the Posterior Segment (TYNI Trial) Recruiting NCT05486468 Phase 3 Yutiq 0.18 MG Drug Implant
28 Multicenter, Randomized Study Evaluating the Value of Antitubercular Treatment During Recurent Anterior Uveitis (URBA) Not yet recruiting NCT04117698 Phase 3 Antitubercular treatment (RIFATER ©);Ethambutol;RIFINAH ©
29 A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Anterior Uveitis Terminated NCT00333996 Phase 2, Phase 3 Dexamethasone
30 A Randomized, Parallel Group, Double-masked, Active-controlled Phase 1/2 Clinical Trial to Evaluate the Efficacy and Safety of Dexamethasone Sodium Phosphate Visulex System for the Treatment of Non-infectious Anterior Uveitis Completed NCT02309385 Phase 1, Phase 2 8% Dexamethasone Sodium Phosphate - Visulex;15% Dexamethasone Sodium Phosphate - Visulex;Prednisolone Acetate (1%) Eye Drops
31 A Randomized, Double-Masked, Dose-Ranging Study to Evaluate the Safety and Tolerability of TRS01 Eye Drops in Participants With Active Non-infectious Anterior Uveitis. Completed NCT04222712 Phase 1, Phase 2 TRS01 eye drops
32 An Open Label Exploratory Study to Assess the Safety, Tolerability and Clinical Activity of Topically Applied ESBA105 in Patients With Acute Anterior Uveitis Completed NCT00823173 Phase 2
33 Phase 2a Study of 0.05% Difluprednate Ophthalmic Emulsion in the Treatment of Anterior Uveitis (Inluding Iritis, Cyclitis, Iridocyclitis, and Panuveitis). Completed NCT00405496 Phase 2 Difluprednate Ophthalmic Emulsion
34 Treatment of Active Anterior Uveitis Associated With JIA, Using Humanized Anti-Tac (HAT, Daclizumab) Completed NCT00130637 Phase 2 Daclizumab
35 A Phase 2 Randomized, Investigator-Masked, Comparator-controlled Trial to Evaluate the Safety and Efficacy of NS2 Eye Drops in Patients With Anterior Uveitis Completed NCT02406209 Phase 2 NS2;Prednisolone acetate ophthalmic suspension (1%)
36 A Multicenter, Randomized, Double-Masked, Active-Controlled Study to Evaluate the Safety and Efficacy of LME636 in Patients With Acute Anterior Uveitis Completed NCT02482129 Phase 2 LME636 60 mg/mL ophthalmic solution;Dexamethasone 0.1% ophthalmic solution;LME636 Vehicle
37 The Treatment of Macular Edema Secondary to Uveitis Using Topical Interferon Gamma Completed NCT01376362 Phase 1, Phase 2 Interferon Gamma-1b
38 A Randomized, Masked, Multicenter Study to Assess the Safety and Efficacy of CLS-TA, Triamcinolone Acetonide Injectable Suspension in the Treatment of Subjects With Macular Edema Following Uveitis Completed NCT02255032 Phase 2 4 mg CLS-TA;0.8 mg CLS-TA
39 A Prospective, Multi-Center, Randomized, Double-Masked, Safety, Tolerability and Efficacy Study of Four Iontophoretic Doses of Dexamethasone Phosphate Ophthalmic Solution in Patients With Non-Infectious Anterior Segment Uveitis Completed NCT00694135 Phase 2 EGP-437 1.6 mA-min at 0.4 with EyeGate® II System;EGP-437 4.8 mA-min at 1.2 mA with EyeGate® II System;EGP-437 10.0 mA-min at 2.5 mA with EyeGate® II System;EGP-437 14.0 mA-min at 3.5 mA with EyeGate® II System
40 Pilot Study for the Evaluation of Intravitreal Infliximab in the Treatment of Uveitic Macular Edema Withdrawn NCT00958906 Phase 1, Phase 2 Infliximab (intravitreal, 2.0mg/0.05ml)
41 Subconjunctival Sirolimus for the Treatment of Autoimmune Active Anterior Uveitis Completed NCT00876434 Phase 1 Sirolimus
42 Pilot Project: The Amplicon and Metatranscriptomic Next-generation Sequencing of Samples From Intra and Extra-intestinal Microbiome in Non-infectious Uveitis Patients to Decipher Possibility Uveitis Pathogenesis Unknown status NCT04126850
43 Quality of Life and Visual Function in Uveitis Patients Unknown status NCT00407316
44 Acute Anterior Uveitis: Psychic Burden and Pain Unknown status NCT01156285
45 Clinical Outcomes of Topical Ganciclovir Treatment in Cytomegalovirus Anterior Uveitis Unknown status NCT01486693
46 Pathogen Detection in Infectious Uveitis in China Unknown status NCT04521673
47 The Contribution of Altered Aqueous Dynamics in the Development of Raised Intraocular Pressure in Patients With Uveitis Completed NCT02765308
48 Ocular Sarcoidosis Open Label Trial of ACTHAR Gel Completed NCT02725177 Repository Corticotropin Injection;Repository Corticotropin Injection -Treatment Extension
49 Retinal Optical Coherence Tomography and Multifocal Electroretinogram; Establishing Normal Ranges Related to Age and Reproductive Factors; With the Use of Anti-inflammatory Medications;In Uncomplicated Anterior Uveitis; Anatomy and Function. Completed NCT00476593 Diclofenac;Dexamethasone
50 Intra-cameral Penetration of Ganciclovir Following Topical Administration of 0.15% Ganciclovir Gel (VIRGAN©) for CMV Anterior Uveitis / Endotheliitis Completed NCT01647529 Ganciclovir

Search NIH Clinical Center for Anterior Uveitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


rimexolone
Scopolamine
Scopolamine Hydrobromide
Tropicamide

Cochrane evidence based reviews: uveitis, anterior

Genetic Tests for Anterior Uveitis

Anatomical Context for Anterior Uveitis

Organs/tissues related to Anterior Uveitis:

MalaCards : Eye, Retina, Endothelial, T Cells, Lymph Node, Neutrophil, Bone Marrow

Publications for Anterior Uveitis

Articles related to Anterior Uveitis:

(show top 50) (show all 8904)
# Title Authors PMID Year
1
Changes in Toll-like receptor (TLR)-2 and TLR4 expression and function but not polymorphisms are associated with acute anterior uveitis. 53 62
17389503 2007
2
Fecal calprotectin levels in acute anterior uveitis in patients with spondyloarthritis. 62
35170654 2023
3
Cardiovascular and disease-related features associated with extra-articular manifestations in axial spondyloarthritis. A multicenter study of 888 patients. 62
36150319 2022
4
Certolizumab Pegol Treatment in Patients with Axial-Spondyloarthritis-Associated Acute Anterior Uveitis: a Narrative Review. 62
36178585 2022
5
Snowball-associated ocular injury - An unusual presentation. 62
36453380 2022
6
Safety of intravitreal metoprolol in eyes with central serous chorioretinopathy. 62
36333649 2022
7
Topical interferon therapy in uveitic macular edema. 62
36453344 2022
8
COVID-19 vaccination and recurrent anterior uveitis. 62
36453363 2022
9
Comparison of metabolic profiles in aqueous humour of Fuchs' syndrome and presumed viral-induced anterior uveitis patients. 62
35849327 2022
10
Alternative Biologic Therapy in Children Failing Conventional TNFα Inhibitors for Refractory, Noninfectious, Chronic Anterior Uveitis. 62
35863492 2022
11
Serum Maresin 1 levels in idiopathic acute anterior uveitis patients. 62
36319522 2022
12
Risk for uveitis relapse after COVID-19 vaccination. 62
36209692 2022
13
Argon laser photocoagulation for treatment of presumed trematode-induced granulomatous anterior uveitis in children. 62
36414261 2022
14
COMPARISON OF PRIMARY AND SECONDARY FORMS OF MULTIPLE EVANESCENT WHITE DOT SYNDROME. 62
36394891 2022
15
A case of intraocular inflammation after intravitreal brolucizumab injection monitored by laser flare-cell photometer. 62
36281264 2022
16
Multimodal imaging in the diagnosis and management of ophthalmia nodosa. 62
36324631 2022
17
Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2. 62
36335665 2022
18
Roles of CCL2 and CCL3 in intraocular inflammation during Bacillus endophthalmitis. 62
36063964 2022
19
Ocular lesions of captive cephalopods. 62
36321800 2022
20
Evaluation of efficacy of intracameral lidocaine and tropicamide injection in manual small-incision cataract surgery: A prospective clinical study. 62
36308110 2022
21
Clinical features and long-term treatment outcome of posterior scleritis. 62
36467362 2022
22
OCULAR INJURIES ASSOCIATED WITH ELASTIC EXERCISE BANDS. 62
33165305 2022
23
Complications of manual small-incision cataract surgery. 62
36308100 2022
24
Therapeutic Potential of d-MAPPS™ for Ocular Inflammatory Diseases and Regeneration of Injured Corneal and Retinal Tissue. 62
36362313 2022
25
Six-month outcomes of infliximab and tocilizumab therapy in non-infectious retinal vasculitis. 62
36443499 2022
26
Iridian anterior segment OCT in rubella uveitis syndrome and cytomegalovirus anterior uveitis: a comparative study. 62
35708847 2022
27
Bilateral anterior uveitis following paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 - Case report and focused review. 62
36383060 2022
28
Fluocinolone acetonide 0.19-mg implant for the treatment of noninfectious uveitis with involvement of the posterior segment: a real-world study. 62
36399176 2022
29
Epidemiology and characteristics of common forms of anterior uveitis at initial presentation in a tertiary facility in Japan. 62
36346554 2022
30
Prompt and Sustained Suppression of Intraocular Inflammation with Adalimumab in Pediatric Patients with Non-Infectious Uveitis Resistant to Traditional Managements: A 6-Month Follow-Up Research. 62
36322874 2022
31
A review of patient-reported outcome measures used in uveitis. 62
36395825 2022
32
RISK OF INTRAOCULAR INFLAMMATION AFTER INJECTION OF ANTIVASCULAR ENDOTHELIAL GROWTH FACTOR AGENTS: A Meta-analysis. 62
36269802 2022
33
Severe Vaso-Occlusive and Ocular Decompression Retinopathy Revealing a Sickle Cell Trait in a Patient with Herpetic Uveitis. 62
36442016 2022
34
DELAYED-ONSET STREPTOCOCCUS INTERMEDIUS ENDOPHTHALMITIS FOLLOWING ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR INTRAVITREAL INJECTION. 62
33165298 2022
35
Clinical and Morphologic Characteristics of Perivenular Fernlike Leakage on Ultrawide-field Fluorescein Angiography. 62
35545196 2022
36
Inflammation after Voretigene Neparvovec Administration in Patients with RPE65-Related Retinal Dystrophy. 62
35760216 2022
37
Endocyclophotocoagulation by pars plana approach in the management of refractory glaucoma with prior phacoemulsification and Ahmed gonioimplantation in a dog. 62
36321590 2022
38
Atypical anterior retinoblastoma: diagnosis by aqueous humor cell-free DNA analysis. 62
36326029 2022
39
A multicenter study of ocular inflammation after COVID-19 vaccination. 62
36417027 2022
40
Bilateral posterior scleritis due to giant cell arteritis. 62
36428030 2022
41
Acquired acoria and iris pearls in leprosy: Case report. 62
34142579 2022
42
Randomized trial of bilateral gene therapy injection for m.11778G > A MT-ND4 Leber optic neuropathy. 62
36350566 2022
43
Onset of spondyloarthritis in a patient treated with adalimumab for relapsing anterior uveitis - efficacy of secukinumab on the joint domain and on ocular inflammatory relapses: A case report. 62
36451402 2022
44
[Colchicine and non-severe ocular inflammation excluding Behcet's disease: 16 cases and literature review]. 62
36068122 2022
45
Ophthalmic manifestations of ROSAH Syndrome, an inherited NF-κB mediated autoinflammatory disease with retinal dystrophy. 62
36332842 2022
46
COVID-19 Vaccine-Associated Ocular Adverse Effects: An Overview. 62
36366386 2022
47
Inflammatory ocular events after inactivated COVID-19 vaccination. 62
36369840 2022
48
Hyphema and secondary glaucoma as a presenting complaint in a dog with chronic lymphocytic leukemia. 62
36415701 2022
49
Long-term outcomes of small-incision cataract surgery in patients with uveitis. 62
36308129 2022
50
Therapeutic Vitrectomy in the Management of Uveitis: Opportunities and Challenges. 62
35608546 2022

Variations for Anterior Uveitis

Expression for Anterior Uveitis

Search GEO for disease gene expression data for Anterior Uveitis.

Pathways for Anterior Uveitis

Pathways related to Anterior Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 CCR6 CD4 CD8A CFHR2 CRP ERAP1
2
Show member pathways
13.64 TNF TLR4 IL6 IL23R IL1B IL17A
3
Show member pathways
13.44 TNF TLR4 TLR2 IL6 IL23R IL1B
4
Show member pathways
13.35 TNF IL6 IL23R IL1B IL17A IL10
5
Show member pathways
13.32 TNF IL6 IL23R IL1B IL17A IL10
6
Show member pathways
12.84 TNF TLR4 TLR2 IL6 IL1B
7
Show member pathways
12.72 TNF TLR4 TLR2 IL6 IL1B
8
Show member pathways
12.67 TNF IL6 IL23R IL1B IL17A IL10
9
Show member pathways
12.62 CD4 IL10 IL17A IL1B IL23R IL6
10 12.61 TNF TLR2 IL1B IL17A IL10 CD8A
11
Show member pathways
12.55 TNF TLR4 TLR2 IL6 IL1B
12
Show member pathways
12.46 TNF TLR4 TLR2 IL6 IL1B
13
Show member pathways
12.31 TNF TLR4 IL6 IL1B
14
Show member pathways
12.29 TNF TLR2 IL6 IL17A
15 12.21 TNF TLR4 TLR2 IL6
16 12.19 TNF IL6 IL1B IL10
17
Show member pathways
12.17 TNF IL23R IL17A IL10 CD8A CD4
18 12.12 TNF IL6 IL1B IL10
19 12.06 TNF IL6 IL10 CD8A CD4
20 12.03 IL1B IL6 TLR4 TNF
21 11.99 TNF IL6 IL23R IL1B IL17A IL10
22 11.94 TNF IL1B IL17A IL10 HLA-B
23
Show member pathways
11.92 TLR4 IL6 IL23R IL17A
24
Show member pathways
11.83 CD4 CD8A CRP IL6
25 11.81 TNF TLR4 IL6 IL1B
26 11.81 TLR4 IL6 IL10 CD4
27 11.76 IL6 IL23R IL1B IL17A CD4
28 11.75 TNF IL6 IL1B IL10 CD8A CD4
29 11.72 TNF TLR4 IL6 IL10
30 11.7 TNF TLR4 IL6 IL10 ICOSLG CRP
31 11.69 TNF TLR4 IL6 IL1B IL10
32
Show member pathways
11.68 TNF IL6 IL1B
33 11.68 TNF IL6 IL1B
34
Show member pathways
11.66 TLR4 TLR2 IL6 IL23R IL1B IL17A
35 11.62 TNF TLR4 CD4
36 11.59 TNF TLR4 TLR2 IL1B
37 11.58 TNF TLR4 IL6
38 11.58 IL10 IL1B IL6 TNF
39
Show member pathways
11.57 TNF TLR4 TLR2 IL6 IL23R IL10
40 11.52 TNF IL6 IL1B
41 11.49 TNF TLR4 IL6
42 11.46 TNF IL23R IL1B IL17A IL10 CD8A
43 11.4 IL10 IL1B IL6 TLR4 TNF
44 11.39 TNF IL6 IL1B IL17A
45 11.33 TNF IL6 IL1B
46 11.32 TNF IL6 IL1B IL17A
47 11.29 TNF IL6 IL17A IL10
48 11.29 TNF IL6 IL1B IL10 CD4
49
Show member pathways
11.28 TNF TLR4 TLR2 IL6 IL23R IL1B
50 11.16 TLR4 IL6 IL1B IL10

GO Terms for Anterior Uveitis

Cellular components related to Anterior Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.3 TNF SERPINA3 RBP3 IL6 IL1B IL17A
2 extracellular region GO:0005576 10.23 ACE CD8A CFHR2 CRP ERAP1 IL10
3 plasma membrane GO:0005887 10.03 ACE CCR6 CD4 CD8A HLA-B TLR2
4 plasma membrane GO:0005886 10.03 ACE CCR6 CD4 CD8A HLA-B TLR2
5 external side of plasma membrane GO:0009897 9.58 TNF TLR4 IL23R IL17A ICOSLG CD8A

Biological processes related to Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.61 CCR6 CD4 ERAP1 ICOSLG IL10 IL1B
2 adaptive immune response GO:0002250 10.45 CD4 CD8A ERAP1 HLA-B ICOSLG IL17A
3 positive regulation of DNA-binding transcription factor activity GO:0051091 10.27 TNF IL6 IL1B IL10
4 positive regulation of tumor necrosis factor production GO:0032760 10.26 TLR4 TLR2 IL6 IL17A
5 cellular response to lipopolysaccharide GO:0071222 10.26 IL10 IL1B IL6 TLR4 TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.24 TNF TLR4 TLR2 IL6 IL1B
7 positive regulation of type II interferon production GO:0032729 10.22 TNF TLR4 IL23R IL1B
8 positive regulation of inflammatory response GO:0050729 10.22 TNF TLR4 TLR2 IL1B ACE
9 positive regulation of NIK/NF-kappaB signaling GO:1901224 10.2 TNF TLR4 TLR2 IL1B
10 positive regulation of interleukin-1 beta production GO:0032731 10.19 TNF TLR4 IL6 IL17A
11 defense response to Gram-negative bacterium GO:0050829 10.18 TLR4 IL6 IL23R IL17A CD4
12 defense response to Gram-positive bacterium GO:0050830 10.18 CRP IL17A IL1B IL6 TLR2 TNF
13 positive regulation of nitric oxide biosynthetic process GO:0045429 10.17 TNF TLR4 IL1B
14 positive regulation of interleukin-10 production GO:0032733 10.16 TLR4 TLR2 IL6
15 acute-phase response GO:0006953 10.15 SERPINA3 IL6 CRP
16 positive regulation of interleukin-12 production GO:0032735 10.15 IL17A IL23R TLR2 TLR4
17 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.14 IL10 IL6 TNF
18 liver regeneration GO:0097421 10.13 IL10 IL6 TNF
19 positive regulation of interleukin-8 production GO:0032757 10.13 TNF TLR4 TLR2 IL6 IL1B
20 negative regulation of neurogenesis GO:0050768 10.12 TNF IL6 IL1B
21 positive regulation of osteoclast differentiation GO:0045672 10.11 TNF IL23R IL17A
22 lipopolysaccharide-mediated signaling pathway GO:0031663 10.11 IL1B TLR2 TLR4 TNF
23 inflammatory response GO:0006954 10.11 CRP IL17A IL1B IL23R IL6 SERPINA3
24 positive regulation of interleukin-6 production GO:0032755 10.1 IL17A IL1B IL6 TLR2 TLR4 TNF
25 positive regulation of glial cell proliferation GO:0060252 10.08 TNF IL6 IL1B
26 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.06 IL17A IL6 TLR4 TNF
27 positive regulation of heterotypic cell-cell adhesion GO:0034116 10.05 IL10 IL1B TNF
28 positive regulation of neuroinflammatory response GO:0150078 10.03 TNF IL6 IL1B
29 positive regulation of chemokine production GO:0032722 10.02 TNF TLR4 TLR2 IL6 IL1B
30 negative regulation of lipid storage GO:0010888 10.01 TNF IL6 CRP
31 negative regulation of cytokine production involved in immune response GO:0002719 9.99 TNF IL10
32 intestinal epithelial structure maintenance GO:0060729 9.98 TLR4 IL17A
33 positive regulation of fever generation GO:0031622 9.98 TNF IL1B
34 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.97 HLA-B ERAP1 ACE
35 vascular endothelial growth factor production GO:0010573 9.97 TNF IL6 IL1B
36 sequestering of triglyceride GO:0030730 9.96 TNF IL1B
37 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.95 TNF IL1B
38 positive regulation of matrix metallopeptidase secretion GO:1904466 9.94 TLR4 TLR2
39 chronic inflammatory response to antigenic stimulus GO:0002439 9.93 IL10 TNF
40 negative regulation of gap junction assembly GO:1903597 9.93 ACE IL1B
41 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.92 TLR2 TLR4
42 immune system process GO:0002376 9.91 TLR4 TLR2 IL23R IL17A ICOSLG HLA-B
43 response to lipopolysaccharide GO:0032496 9.7 TNF TLR4 TLR2 IL23R IL1B IL10
44 immune response GO:0006955 9.6 TNF TLR4 TLR2 IL6 IL1B IL17A

Molecular functions related to Anterior Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 TNF IL6 IL1B IL17A IL10
2 lipopolysaccharide immune receptor activity GO:0001875 9.26 TLR4 TLR2

Sources for Anterior Uveitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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