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MCID: ANT034
MIFTS: 50

Anterior Uveitis

Categories: Rare diseases, Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Anterior Uveitis

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MalaCards integrated aliases for Anterior Uveitis:

Name: Anterior Uveitis 53 73
Iridocyclitis 53 73
Acute Anterior Uveitis 73

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


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Summaries for Anterior Uveitis

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MalaCards based summary : Anterior Uveitis, also known as iridocyclitis, is related to spondyloarthropathy and uveitis. An important gene associated with Anterior Uveitis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Ganciclovir and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Anterior Uveitis

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Diseases in the Uveitis family:

Posterior Uveitis Intermediate Uveitis
Infectious Anterior Uveitis Anterior Uveitis
Infectious Posterior Uveitis

Diseases related to Anterior Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 245)
# Related Disease Score Top Affiliating Genes
1 spondyloarthropathy 30.5 HLA-A HLA-B IL6
2 uveitis 30.1 CCL2 CTLA4 HLA-B IL2RA
3 cytomegalovirus infection 30.0 IL2RA IL6
4 reactive arthritis 29.8 HLA-B IL6
5 graft-versus-host disease 29.8 HLA-A HLA-B IL6
6 primary biliary cholangitis 29.7 CTLA4 PTPN22
7 psoriatic arthritis 29.4 HLA-B IL6 PTPN22
8 arthritis 29.3 CCL2 IL6 PTPN22
9 chikungunya 29.3 CCL2 IL6
10 common variable immunodeficiency 29.3 CTLA4 IL2RA IL6
11 pneumonia 29.2 CCL2 IL6 TLR2
12 stromal keratitis 28.7 CCL2 IL2RA IL6
13 trypanosomiasis 28.7 CCL2 IL6 TLR2
14 meningitis 28.7 CCL2 IL6 TLR2
15 temporal arteritis 28.5 CCL2 IL6 PTPN22
16 vogt-koyanagi-harada disease 28.4 HLA-A HLA-B IL2RA PTPN22
17 multiple sclerosis 28.2 CCL2 CTLA4 IL2RA IL6
18 diabetes mellitus 27.2 CTLA4 HLA-A HLA-B IL2RA IL6 PTPN22
19 inflammatory bowel disease 26.7 CCL2 CTLA4 HLA-B IL6 PTPN22 TLR2
20 rheumatoid arthritis 25.6 CCL2 CTLA4 HLA-B IL2RA IL6 PTPN22
21 infectious anterior uveitis 12.3
22 idiopathic anterior uveitis 12.2
23 blau syndrome 11.0
24 systemic onset juvenile idiopathic arthritis 11.0
25 phenytoin or carbamazepine toxicity 10.7 HLA-A HLA-B
26 postherpetic neuralgia 10.7 HLA-A HLA-B
27 atrial tachyarrhythmia with short pr interval 10.6 HLA-A HLA-B
28 glaucomatocyclitic crisis 10.6 HLA-A HLA-B
29 pars planitis 10.6 HLA-A HLA-B
30 pityriasis rosea 10.6 HLA-A HLA-B
31 chronic pyelonephritis 10.6 HLA-A HLA-B
32 idiopathic bronchiectasis 10.6 HLA-A HLA-B
33 histoplasmosis 10.6 HLA-A HLA-B
34 separation anxiety disorder 10.5 HLA-A HLA-B
35 anca-associated vasculitis 10.5 CTLA4 IL6
36 geographic tongue 10.5 HLA-A HLA-B
37 periodontitis, chronic 10.5 IL6 TLR2
38 periapical periodontitis 10.4 IL6 TLR2
39 mesenteric lymphadenitis 10.4 IL6 TLR2
40 haemophilus influenzae 10.4 CFH TLR2
41 radiculopathy 10.4 IL2RA IL6
42 spondyloarthropathy 1 10.4
43 spondylitis 10.4
44 posterior uveitis 10.4 CFH IL2RA
45 rosacea 10.4 IL6 TLR2
46 rheumatic heart disease 10.4 HLA-A IL6
47 echinococcosis 10.4 HLA-B IL6
48 paraneoplastic pemphigus 10.3 HLA-A HLA-B
49 ileitis 10.3 IL6 TLR2
50 infective endocarditis 10.3 IL6 TLR2

Graphical network of the top 20 diseases related to Anterior Uveitis:



Diseases related to Anterior Uveitis
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Symptoms & Phenotypes for Anterior Uveitis

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GenomeRNAi Phenotypes related to Anterior Uveitis according to GeneCards Suite gene sharing:

26 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.85 HLA-A HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.85 HLA-B HLA-A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.85 IL2RA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.85 HLA-B HLA-A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.85 IL2RA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.85 IL2RA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.85 IL2RA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.85 HLA-B HLA-A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.85 IL2RA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.85 IL2RA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.85 HLA-A HLA-B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.85 IL2RA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.85 IL2RA HLA-A HLA-B
14 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.85 IL2RA
15 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.85 IL2RA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.85 IL2RA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.85 HLA-A HLA-B
18 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.85 IL2RA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.85 IL2RA
20 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.85 IL2RA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.85 IL2RA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.85 HLA-A HLA-B
23 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.85 HLA-A HLA-B
24 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.85 IL2RA

MGI Mouse Phenotypes related to Anterior Uveitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.55 IL2RA IL6 PTPN22 TLR2 CTLA4
2 immune system MP:0005387 9.5 IL6 PTPN22 TLR2 CCL2 CFH CTLA4
3 respiratory system MP:0005388 9.02 IL6 PTPN22 TLR2 CTLA4 IL2RA
Sources

Drugs & Therapeutics for Anterior Uveitis

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Drugs for Anterior Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 112)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ganciclovir Approved, Investigational Phase 4,Not Applicable 82410-32-0 3454
2
Methotrexate Approved Phase 4,Not Applicable 1959-05-2, 59-05-2 126941
3
Adalimumab Approved Phase 4,Phase 3 331731-18-1 16219006
4
Ephedrine Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 299-42-3 9294
5
Pseudoephedrine Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 90-82-4 7028
6
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
7
Dinoprost Tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
8
Certolizumab pegol Approved Phase 4,Phase 3 428863-50-7
9
leucovorin Approved, Nutraceutical Phase 4,Not Applicable 58-05-9 143 6006
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 59-30-3 6037
11
Dinoprost Investigational Phase 4 551-11-1 5283078
12 Folic Acid Antagonists Phase 4,Not Applicable
13 Ganciclovir triphosphate Phase 4,Not Applicable
14 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15 Dermatologic Agents Phase 4,Phase 3,Not Applicable
16 Nucleic Acid Synthesis Inhibitors Phase 4,Not Applicable
17 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Vitamin B Complex Phase 4,Not Applicable
21 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
23 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Antirheumatic Agents Phase 4,Phase 3,Not Applicable
25 Antimetabolites Phase 4,Not Applicable
26 Antiviral Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
27 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Antimetabolites, Antineoplastic Phase 4,Not Applicable
29 beta-endorphin Phase 4,Not Applicable
30 Respiratory System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
31 Adrenocorticotropic Hormone Phase 4,Not Applicable
32 Nasal Decongestants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
33 Tetrahydrozoline Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Oxytocics Phase 4
36 Vasoconstrictor Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
37 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Antihypertensive Agents Phase 4
39 Anti-Infective Agents, Local Phase 4,Phase 3
40 Lubricant Eye Drops Phase 4
41 Melanocyte-Stimulating Hormones Phase 4,Not Applicable
42 Benzalkonium Compounds Phase 4,Phase 3
43 Folate Nutraceutical Phase 4,Not Applicable
44 Vitamin B9 Nutraceutical Phase 4,Not Applicable
45
Ranibizumab Approved Phase 2, Phase 3 347396-82-1 459903
46
Etanercept Approved, Investigational Phase 3,Not Applicable 185243-69-0
47
Prednisolone Approved, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
48
Acyclovir Approved Phase 3 59277-89-3 2022
49
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
50
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743

Interventional clinical trials:

(show top 50) (show all 63)
# Name Status NCT ID Phase Drugs
1 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
2 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
3 A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment Completed NCT02897115 Phase 4
4 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4 2% guttae ganciclovir
5 Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis Recruiting NCT02769702 Phase 4 Acthar
6 A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU Active, not recruiting NCT03020992 Phase 4 Certolizumab Pegol
7 Methotrexate in the Treatment of Axial Spondyloarthritis Withdrawn NCT00298012 Phase 4 Methotrexate
8 Herpetic Eye Disease Study (HEDS) I Unknown status NCT00000138 Phase 3 Prednisolone Phosphate;Acyclovir
9 Double-dose Ranibizumab for Polypoidal Choroidal Vasculopathy Unknown status NCT02769169 Phase 2, Phase 3 Lucentis® (Raibizumab) double-dose;Lucentis® (Raibizumab) regular-dose
10 Safety and Efficacy of Difluprednate 0.05% for the Treatment of Anterior Uveitis Completed NCT01201798 Phase 3 Difluprednate 0.05% ophthalmic emulsion;Prednisolone acetate 1.0% ophthalmic suspension
11 A Multi-center Study to Assess the Efficacy and Safety of LX211 in Active Non-infectious Anterior Uveitis Completed NCT00404885 Phase 3 Placebo;LX211;LX211;LX211
12 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00406887 Phase 3 Difluprednate Ophthalmic Emulsion
13 Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis Completed NCT01505088 Phase 3 40 mg/mL Dexamethasone phosphate ophthalmic solution;Prednisolone Acetate (1%) Eyedrops;100 mM sodium citrate buffer solution;Placebo Eyedrops
14 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Severe Uveitis Completed NCT00407056 Phase 3 Difluprednate Ophthalmic Emulsion
15 Study of Difluprednate in the Treatment of Uveitis Completed NCT00501579 Phase 3 Difluprednate;Prednisolone Acetate
16 A Study of the Long-term Safety and Efficacy of Adalimumab in Subjects With Intermediate-, Posterior-, or Pan-uveitis Completed NCT01148225 Phase 3 adalimumab
17 Herpetic Eye Disease Study (HEDS) II Completed NCT00000139 Phase 3 Acyclovir
18 Suprachoroidal Injection of CLS-TA in Subjects Non-infectious Uveitis Completed NCT03097315 Phase 3
19 Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis Completed NCT02595398 Phase 3 4mg CLS-TA Suprachoriodal Injection;Sham Procedure
20 CLARITY Extension Study Completed NCT00641537 Phase 3 Cladribine;Placebo;Cladribine;Cladribine;Placebo
21 A Phase 3 Study to Evaluate ADX-102 Ophthalmic Solution in Subjects With Non-infectious Anterior-uveitis. Recruiting NCT03131154 Phase 3 ADX-102 Ophthalmic Solution (0.5%);Vehicle of ADX-102 Ophthalmic Solution
22 Treatment Tapering in JIA With Inactive Disease Recruiting NCT02840175 Phase 3 etanercept;adalimumab;Abatacept;Tocilizumab
23 A Long Term Extension Study of Ixekizumab (LY2439821) in Participants With Axial Spondyloarthritis Recruiting NCT03129100 Phase 3 Ixekizumab;Placebo
24 A Study of Ixekizumab (LY2439821) in Participants With Nonradiographic Axial Spondyloarthritis Recruiting NCT02757352 Phase 3 Ixekizumab;Placebo
25 Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Non-Infectious Anterior Uveitis Active, not recruiting NCT02517619 Phase 3 Dexamethasone Phosphate Ophthalmic Solution;Prednisolone Acetate Ophthalmic (1%)
26 A Study of Ixekizumab (LY2439821) in TNF Inhibitor Experienced Participants With Radiographic Axial Spondyloarthritis Active, not recruiting NCT02696798 Phase 3 Ixekizumab;Placebo
27 A Study of Ixekizumab (LY2439821) in bDMARD-Naive Participants With Radiographic Axial Spondyloarthritis Active, not recruiting NCT02696785 Phase 3 Ixekizumab;Placebo;Adalimumab
28 Multicenter Study Evaluating Certolizumab Pegol Compared to Placebo in Subjects With axSpA Without X-ray Evidence of AS Active, not recruiting NCT02552212 Phase 3
29 Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis Not yet recruiting NCT03576898 Phase 2, Phase 3 Topical ganciclovir versus oral valganciclovir versus placebo
30 A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Anterior Uveitis Terminated NCT00333996 Phase 2, Phase 3 Dexamethasone
31 Proof of Concept Study to Evaluate Safety and Efficacy of LME636 in the Treatment of Acute Anterior Uveitis Completed NCT02482129 Phase 2 LME636 60 mg/mL ophthalmic solution;Dexamethasone 0.1% ophthalmic solution;LME636 Vehicle
32 A Safety and Efficacy Study of NS2 in Patients With Anterior Uveitis Completed NCT02406209 Phase 2 NS2;Prednisolone acetate ophthalmic suspension (1%)
33 Safety and Efficacy Study of DSP-Visulex for the Treatment of Anterior Uveitis Completed NCT02309385 Phase 1, Phase 2 8% Dexamethasone Sodium Phosphate - Visulex;15% Dexamethasone Sodium Phosphate - Visulex;Prednisolone Acetate (1%) Eye Drops
34 Exploratory Study on Topical ESBA105 in Acute Anterior Uveitis Completed NCT00823173 Phase 2
35 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00405496 Phase 2 Difluprednate Ophthalmic Emulsion
36 Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis Completed NCT00130637 Phase 2 Daclizumab
37 Safety and Efficacy Study of Iontophoresis and Dexamethasone Phosphate to Treat Anterior Uveitis Completed NCT00694135 Phase 2 EGP-437 1.6 mA-min at 0.4 with EyeGate® II System;EGP-437 4.8 mA-min at 1.2 mA with EyeGate® II System;EGP-437 10.0 mA-min at 2.5 mA with EyeGate® II System;EGP-437 14.0 mA-min at 3.5 mA with EyeGate® II System
38 Topical Interferon Gamma for Macular Edema Secondary to Uveitis Completed NCT01376362 Phase 1, Phase 2 Interferon Gamma-1b
39 Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis Completed NCT02255032 Phase 2 4 mg CLS-TA;0.8 mg CLS-TA
40 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2 AIN457;AIN 457;AIN457
41 A Phase I/IIa Study for the Treatment of Uveitis With Iontophoresis Withdrawn NCT00499551 Phase 1, Phase 2
42 Subconjunctival Sirolimus for the Treatment of Autoimmune Active Anterior Uveiti Completed NCT00876434 Phase 1 Sirolimus
43 Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Withdrawn NCT02042027 Phase 1 Gamunex-C
44 Acute Anterior Uveitis: Psychic Burden and Pain Unknown status NCT01156285
45 Clinical Outcomes of Topical Ganciclovir Treatment in Cytomegalovirus Anterior Uveitis Unknown status NCT01486693
46 Etanercept: Single Blind Control Study in Ocular Manifestations of Behcet's Disease Unknown status NCT00931957 Not Applicable Etanercept, Methotrexate, Prednisolone
47 Quality of Life and Visual Function in Uveitis Patients Unknown status NCT00407316
48 Causes of Visual Loss in Retinal Disease Unknown status NCT01613963 Immunosuppressive Agents
49 PEMF: an Adjunct Therapy for Anterior Uveitis Completed NCT01154010 Not Applicable
50 Topical Administration of 0.15% Ganciclovir Gel for CMV Anterior Uveitis / Endotheliitis Completed NCT01647529 Not Applicable Ganciclovir

Search NIH Clinical Center for Anterior Uveitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :
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Genetic Tests for Anterior Uveitis

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Anatomical Context for Anterior Uveitis

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MalaCards organs/tissues related to Anterior Uveitis:

41
Eye, Endothelial, T Cells, Thyroid, Breast, Neutrophil, Skin
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Publications for Anterior Uveitis

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Articles related to Anterior Uveitis:

(show top 50) (show all 667)
# Title Authors Year
1
Inflammatory bowel disease and acute anterior uveitis, but not psoriasis are associated with disease duration in Axial SpA: results from the (Be)Giant and ASPECT cohort. ( 29740978 )
2018
2
Diagnosis of Cytomegalovirus Anterior Uveitis in Two European Referral Centers. ( 29377783 )
2018
3
The pathogenic role of dendritic cells in non-infectious anterior uveitis. ( 29763582 )
2018
4
Increased Circulating Proinflammatory T Lymphocytes in Children with Different Forms of Anterior Uveitis: Results from a Pilot Study. ( 29771573 )
2018
5
Recurrent anterior uveitis and subsequent incidence of ankylosing spondylitis: a nationwide cohort study from 2002 to 2013. ( 29415753 )
2018
6
A study of the key genes and inflammatory signaling pathways involved in HLA-B27-associated acute anterior uveitis families. ( 29620146 )
2018
7
Clinical Characteristics of Herpes Simplex Virus Associated Anterior Uveitis. ( 29345511 )
2018
8
Elevated interleukin 37 expression associated with disease activity in HLA-B27 associated anterior uveitis and idiopathic anterior uveitis. ( 29424310 )
2018
9
Childhood Arthritis and Rheumatology Research Alliance consensus treatment plans for juvenile idiopathic arthritis-associated and idiopathic chronic anterior uveitis. ( 29806733 )
2018
10
Association of IL33 and IL1RAP polymorphisms with acute anterior uveitis. ( 29424312 )
2018
11
Clinical Features of CMV-Associated Anterior Uveitis. ( 29172842 )
2018
12
Immunopathology of Virus-Induced Anterior Uveitis. ( 29543540 )
2018
13
Hypertensive acute granulomatous anterior uveitis as a side effect of topical brimonidine. ( 29910082 )
2018
14
Tonic Pupil in Cytomegalovirus Anterior Uveitis in an Immunocompetent Adult Male - A Case Report. ( 29028408 )
2018
15
Multiplex Cytokine Analysis of Aqueous Humor in Juvenile Idiopathic Arthritis-Associated Anterior Uveitis With or Without Secondary Glaucoma. ( 29675026 )
2018
16
Prevalence of axial spondyloarthritis in patients with acute anterior uveitis: a cross-sectional study utilising MRI. ( 29531779 )
2018
17
PCR Multiplex for CMV Detection in Patients with Anterior Uveitis. ( 29474137 )
2018
18
Gut Microbiota Composition and Fecal Metabolic Phenotype in Patients With Acute Anterior Uveitis. ( 29625474 )
2018
19
Immunohistochemical characterization of feline lymphoplasmacytic anterior uveitis. ( 29517855 )
2018
20
Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis. ( 29511745 )
2018
21
Spondyloarthritis, Acute Anterior Uveitis, and Fungi: Updating the Catterall-King Hypothesis. ( 29675414 )
2018
22
Clinical features of patients with diabetic anterior uveitis. ( 29563110 )
2018
23
Syphilis-Related Eye Disease Presenting as Bilateral Papilledema, Retinal Nerve Fiber Layer Hemorrhage, and Anterior Uveitis in a Penicillin-Allergic Patient. ( 29670780 )
2018
24
Raised intracranial pressure with bilateral anterior uveitis. ( 29891509 )
2018
25
Chronic Anterior Uveitis in Children: Psychosocial Challenges for Patients and Their Families. ( 29601821 )
2018
26
Differential Diagnosis of Viral-Induced Anterior Uveitis. ( 29869892 )
2018
27
Anterior uveitis. ( 29290458 )
2018
28
Virus-Induced Anterior Uveitis (VIAU) in Immunocompromised Patients. ( 29969370 )
2018
29
Document of treatment recommendations for non-infectious anterior uveitis. ( 28911893 )
2017
30
MicroRNA-146a Alleviates Experimental Autoimmune Anterior Uveitis in the Eyes of Lewis Rats. ( 29434444 )
2017
31
Rare case of herpes zoster ophthalmicus with orbital myositis, oculomotor nerve palsy and anterior uveitis. ( 28195080 )
2017
32
Efficacy and safety of an extemporaneous preparation of 2% ganciclovir eye drops in CMV anterior uveitis. ( 29354718 )
2017
33
Multimodal Imaging in Anterior Uveitis. ( 28696173 )
2017
34
Efficacy and safety of immunomodulatory drugs in patients with anterior uveitis: A systematic literature review. ( 29049193 )
2017
35
Anticentromere antibody positive Ackerman's Syndrome with Granulomatous Anterior Uveitis. ( 28605750 )
2017
36
ADJUVITE: a double-blind, randomised, placebo-controlled trial of adalimumab in early onset, chronic, juvenile idiopathic arthritis-associated anterior uveitis. ( 29275333 )
2017
37
An unusual case of bilateral anterior uveitis related to moxifloxacin: the first report in Latin America. ( 28706771 )
2017
38
In vivo Confocal Microscopy of Posner-Schlossman Syndrome: Comparison with herpes simplex keratitis, HLA-B27 anterior uveitis and acute attack of primary angle closure. ( 28852187 )
2017
39
Review for Disease of the Year: Varicella Zoster Virus-Induced Anterior Uveitis. ( 29023181 )
2017
40
Comparison of the Diagnostic Power of Serum IL-6, IL-8 and TNF-I+ for the Idiopathic Anterior Uveitis in Children. ( 29226649 )
2017
41
Chikungunya Virus Infection Associated with Encephalitis and Anterior Uveitis. ( 29020499 )
2017
42
Risk Factors for Secondary Glaucoma in Herpetic Anterior Uveitis. ( 28666730 )
2017
43
Fibrinous anterior uveitis and recurrent epithelial erosion following topical tetracaine abuse. ( 28521706 )
2017
44
Sacroiliac Joint Magnetic Resonance Imaging in Asymptomatic Patients with Recurrent Acute Anterior Uveitis: A Proof-of-concept Study. ( 29093157 )
2017
45
Clinical features of HLA-B27-positive acute anterior uveitis with or without ankylosing spondylitis in a Chinese cohort. ( 28607176 )
2017
46
Acute Bilateral Anterior Uveitis after a Single Intravenous Infusion of Zoledronic Acid in Metastatic Breast Cancer. ( 28682020 )
2017
47
Anterior segment optical coherence tomography and retained vegetal intraocular foreign body masquerading as chronic anterior uveitis. ( 28536985 )
2017
48
Bilateral Acute Anterior Uveitis and Conjunctivitis following Intravenous Zoledronic Acid. ( 28792180 )
2017
49
Difluprednate 0.05% versus Prednisolone Acetate 1% for Endogenous Anterior Uveitis: Pooled Efficacy Analysis of Two Phase 3 Studies. ( 29260952 )
2017
50
Botulinum toxin-induced acute anterior uveitis in a patient with BehAset's disease under infliximab treatment: a case report. ( 28468639 )
2017
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Variations for Anterior Uveitis

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Expression for Anterior Uveitis

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Search GEO for disease gene expression data for Anterior Uveitis.
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Pathways for Anterior Uveitis

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Pathways related to Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.5 CCL2 CFH CTLA4 HLA-A HLA-B IL2RA
2
Class I MHC mediated antigen processing and presentation 66
Show member pathways
 13.17 CTLA4 HLA-A HLA-B PTPN22 TLR2
3
Cytokine Signaling in Immune system 66
Show member pathways
 13.07 CCL2 HLA-A HLA-B IL2RA IL6
4
PI3K-Akt signaling pathway 37
Show member pathways
 12.66 HLA-A HLA-B IL2RA IL6 TLR2
5
Allograft rejection 1 37
Show member pathways
 12.51 CTLA4 HLA-A HLA-B IL2RA IL6
6
Regulation of IFNA signaling 66
Show member pathways
 12.35 HLA-A HLA-B IL2RA IL6
7
Kaposi's sarcoma-associated herpesvirus infection 37
Show member pathways
 12.3 HLA-A HLA-B IL6 TLR2
8
Antigen processing-Cross presentation 66
Show member pathways
 12.23 HLA-A HLA-B TLR2
9
Th17 cell differentiation 37
Show member pathways
 12.2 IL2RA IL6 TLR2
10
Endocytosis 37
12.15 HLA-A HLA-B IL2RA
11
HTLV-I infection 37
12.11 HLA-A HLA-B IL2RA IL6
12
IL-17 Family Signaling Pathways 65
Show member pathways
 12.08 CCL2 IL6 TLR2
13
NF-kappaB Signaling 4
12.07 CCL2 CTLA4 IL2RA PTPN22 TLR2
14
Cellular senescence (KEGG) 37
11.9 HLA-A HLA-B IL6
15
Phagosome 37
11.87 HLA-A HLA-B TLR2
16
Cell adhesion molecules (CAMs) 37
11.83 CTLA4 HLA-A HLA-B
17
Influenza A 37
Show member pathways
 11.79 CCL2 HLA-A HLA-B IL2RA IL6 TLR2
18
Interleukin-10 signaling 66
11.31 CCL2 IL6
19
MSP-RON Signaling 64
11.3 CCL2 TLR2
20
Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway 1
11.28 IL2RA IL6
21
Rheumatoid arthritis 37
11.21 CCL2 CTLA4 IL6 TLR2
22
Malaria 37
11.19 CCL2 IL6 TLR2
23
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.11 CCL2 IL6
24
Antigen Presentation- Folding, assembly and peptide loading of class I MHC 66
10.95 HLA-A HLA-B
25
IL1 and megakaryocytes in obesity 1
10.93 CCL2 TLR2
Sources

GO Terms for Anterior Uveitis

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Cellular components related to Anterior Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.46 HLA-A HLA-B IL2RA TLR2
2 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-A HLA-B
3 MHC class I protein complex GO:0042612 8.96 HLA-A HLA-B
4 phagocytic vesicle membrane GO:0030670 8.8 HLA-A HLA-B TLR2

Biological processes related to Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.67 CCL2 IL2RA IL6 TLR2
2 monocyte chemotaxis GO:0002548 9.54 CCL2 IL6
3 antigen processing and presentation GO:0019882 9.52 HLA-A HLA-B
4 negative regulation of T cell proliferation GO:0042130 9.51 CTLA4 IL2RA
5 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.49 HLA-A HLA-B
6 negative regulation of immune response GO:0050777 9.48 CTLA4 IL2RA
7 positive regulation of chemokine production GO:0032722 9.46 IL6 TLR2
8 regulation of regulatory T cell differentiation GO:0045589 9.43 CTLA4 IL2RA
9 immune system process GO:0002376 9.43 CTLA4 HLA-A HLA-B IL2RA PTPN22 TLR2
10 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.4 CCL2 TLR2
11 lipopolysaccharide-mediated signaling pathway GO:0031663 9.33 CCL2 PTPN22 TLR2
12 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.32 HLA-A HLA-B
13 protection from natural killer cell mediated cytotoxicity GO:0042270 9.26 HLA-A HLA-B
14 immune response GO:0006955 9.17 CCL2 CTLA4 HLA-A HLA-B IL2RA IL6

Molecular functions related to Anterior Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.62 HLA-A HLA-B
Sources

Sources for Anterior Uveitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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