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MCID: ANT034
MIFTS: 54

Anterior Uveitis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Anterior Uveitis

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MalaCards integrated aliases for Anterior Uveitis:

Name: Anterior Uveitis 54 17 74
Iridocyclitis 54 74
Acute Anterior Uveitis 74

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases Neuronal diseases Immune diseases
See all MalaCards categories (disease lists)


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Summaries for Anterior Uveitis

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MalaCards based summary : Anterior Uveitis, also known as iridocyclitis, is related to uveitis and spondylitis. An important gene associated with Anterior Uveitis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Adalimumab and Ganciclovir have been mentioned in the context of this disorder. Affiliated tissues include eye, prostate and thyroid, and related phenotypes are cardiovascular system and hematopoietic system

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Related Diseases for Anterior Uveitis

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Diseases in the Uveitis family:

Autoimmune Uveitis Posterior Uveitis
Intermediate Uveitis Infectious Anterior Uveitis
Anterior Uveitis Infectious Posterior Uveitis

Diseases related to Anterior Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 418)
# Related Disease Score Top Affiliating Genes
1 uveitis 31.1 CTLA4 HLA-B IL2RA TNF
2 spondylitis 31.1 HLA-B IL6 TNF
3 spondyloarthropathy 1 31.0 HLA-B TLR4 TNF
4 arthritis 30.7 IL6 PTPN22 TNF
5 choroiditis 30.4 CFH TNF
6 spondyloarthropathy 30.3 HLA-B IL6 TNF
7 juvenile rheumatoid arthritis 30.2 IL2RA IL6 TNF
8 localized scleroderma 30.2 IL6 TNF
9 panuveitis 30.1 HLA-B TNF
10 glaucomatocyclitic crisis 30.1 HLA-B TNF
11 joint disorders 30.1 IL6 TNF
12 cytomegalovirus retinitis 30.1 HLA-B TNF
13 leprosy 3 30.0 TLR2 TNF
14 multifocal choroiditis 30.0 CFH TNF
15 cysticercosis 30.0 IL6 TLR4
16 ulcerative colitis 29.9 IL6 TLR4 TNF
17 mycoplasma pneumoniae pneumonia 29.9 IL6 TLR2 TNF
18 mycobacterium abscessus 29.8 TLR2 TNF
19 toxoplasmosis 29.8 IL6 TLR2 TLR4 TNF
20 cytomegalovirus infection 29.8 HLA-B IL6 TNF
21 graft-versus-host disease 29.8 HLA-B IL6 TNF
22 inflammatory bowel disease 29.7 IL6 TLR2 TLR4 TNF
23 peritonitis 29.7 IL6 TLR2 TNF
24 pneumonia 29.6 IL6 TLR2 TLR4 TNF
25 leptospirosis 29.6 IL6 TLR2 TNF
26 temporal arteritis 29.6 IL6 PTPN22 TNF
27 bacterial meningitis 29.6 IL6 TLR2 TNF
28 meningitis 29.6 IL6 TLR2 TNF
29 leishmaniasis 29.6 TLR2 TLR4 TNF
30 trypanosomiasis 29.6 IL6 TLR2 TNF
31 rheumatic disease 29.6 HLA-B IL2RA TNF
32 chlamydia 29.5 IL6 TLR2 TLR4 TNF
33 tuberculous meningitis 29.5 TLR2 TNF
34 lupus erythematosus 29.5 CTLA4 PTPN22 TNF
35 colitis 29.4 CTLA4 IL6 TLR4 TNF
36 stromal keratitis 29.4 IL2RA IL6 TNF
37 psoriatic arthritis 29.4 HLA-B IL6 PTPN22 TNF
38 vogt-koyanagi-harada disease 29.3 HLA-B IL2RA PTPN22
39 multiple sclerosis 29.3 CTLA4 IL2RA IL6 TNF
40 q fever 29.3 IL6 TLR2 TLR4 TNF
41 intermediate uveitis 29.2 HLA-B IL2RA IL6 TNF
42 acquired immunodeficiency syndrome 29.1 HLA-B IL2RA IL6 TNF
43 behcet syndrome 28.5 CTLA4 HLA-B IL2RA IL6 TLR4 TNF
44 common variable immunodeficiency 28.4 CTLA4 IL2RA IL6 TLR2 TNF
45 diabetes mellitus 28.3 CTLA4 HLA-B IL2RA IL6 PTPN22 TNF
46 rheumatoid arthritis 27.8 CTLA4 HLA-B IL2RA IL6 PTPN22 TLR2
47 systemic lupus erythematosus 27.6 CTLA4 IL2RA IL6 PTPN22 TLR2 TLR4
48 infectious anterior uveitis 12.5
49 idiopathic anterior uveitis 12.4
50 fuchs' heterochromic uveitis 12.3

Graphical network of the top 20 diseases related to Anterior Uveitis:



Diseases related to Anterior Uveitis
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Symptoms & Phenotypes for Anterior Uveitis

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MGI Mouse Phenotypes related to Anterior Uveitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 CFH CTLA4 IL6 PTPN22 TLR2 TLR4
2 hematopoietic system MP:0005397 10.01 CFH CTLA4 IL2RA IL6 PTPN22 TLR2
3 digestive/alimentary MP:0005381 10 CTLA4 IL2RA IL6 PTPN22 TLR2 TLR4
4 homeostasis/metabolism MP:0005376 9.97 CFH CTLA4 IL2RA IL6 PTPN22 TLR2
5 immune system MP:0005387 9.92 CFH CTLA4 IL2RA IL6 PTPN22 TLR2
6 endocrine/exocrine gland MP:0005379 9.91 CTLA4 IL2RA IL6 PTPN22 TLR2 TNF
7 mortality/aging MP:0010768 9.76 CFH CTLA4 IL2RA IL6 PTPN22 TLR2
8 liver/biliary system MP:0005370 9.73 CTLA4 IL6 PTPN22 TLR2 TLR4 TNF
9 renal/urinary system MP:0005367 9.35 CFH IL6 PTPN22 TLR2 TLR4
10 respiratory system MP:0005388 9.17 CTLA4 IL2RA IL6 PTPN22 TLR2 TLR4
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Drugs & Therapeutics for Anterior Uveitis

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Drugs for Anterior Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 119)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4,Phase 3 331731-18-1 16219006
2
Ganciclovir Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 82410-32-0 3454
3
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
4
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
5
Acyclovir Approved Phase 4,Phase 3 59277-89-3 2022
6
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
7
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
8
leucovorin Approved Phase 4,Phase 1,Not Applicable 58-05-9 143 6006
9
Methotrexate Approved Phase 4,Not Applicable 1959-05-2, 59-05-2 126941
10
Dinoprost tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
11
Dinoprost Approved, Investigational Phase 4 551-11-1 5283078
12
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
13
Difluprednate Approved Phase 4,Phase 3,Phase 2 23674-86-4 443936
14
Certolizumab pegol Approved Phase 4,Phase 3 428863-50-7
15
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Not Applicable 59-30-3 6037
16
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2920-86-7
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 Antirheumatic Agents Phase 4,Phase 3,Not Applicable
22 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Ganciclovir triphosphate Phase 4,Phase 2,Phase 3,Not Applicable
24 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
26 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Methylprednisolone Acetate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Prednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Antimetabolites, Antineoplastic Phase 4,Not Applicable
31 Folate Phase 4,Phase 1,Not Applicable
32 Vitamin B9 Phase 4,Phase 1,Not Applicable
33 Vitamin B Complex Phase 4,Phase 1,Not Applicable
34 Folic Acid Antagonists Phase 4,Phase 1,Not Applicable
35 Dermatologic Agents Phase 4,Phase 3,Not Applicable
36 Antimetabolites Phase 4,Not Applicable
37 Melanocyte-Stimulating Hormones Phase 4,Not Applicable
38 beta-endorphin Phase 4,Not Applicable
39 Adrenocorticotropic Hormone Phase 4,Not Applicable
40 Oxytocics Phase 4
41 Benzalkonium Compounds Phase 4,Phase 3
42 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Lubricant Eye Drops Phase 4
44 Antihypertensive Agents Phase 4
45 Anti-Infective Agents, Local Phase 4,Phase 3
46 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 valacyclovir Phase 4
48
Ranibizumab Approved Phase 2, Phase 3 347396-82-1 459903
49
Etanercept Approved, Investigational Phase 3,Not Applicable 185243-69-0
50
Fluprednisolone Approved Phase 3,Phase 2 53-34-9

Interventional clinical trials:

(show top 50) (show all 69)
# Name Status NCT ID Phase Drugs
1 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
2 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
3 A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment Completed NCT02897115 Phase 4
4 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4 2% guttae ganciclovir
5 A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU Active, not recruiting NCT03020992 Phase 4 Certolizumab Pegol
6 Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis Not yet recruiting NCT03626376 Phase 4 oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily;oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily + topical corticosteroid eye drops
7 Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis Terminated NCT02769702 Phase 4 Acthar
8 Methotrexate in the Treatment of Axial Spondyloarthritis Withdrawn NCT00298012 Phase 4 Methotrexate
9 Herpetic Eye Disease Study (HEDS) I Unknown status NCT00000138 Phase 3 Prednisolone Phosphate;Acyclovir
10 Double-dose Ranibizumab for Polypoidal Choroidal Vasculopathy Unknown status NCT02769169 Phase 2, Phase 3 Lucentis® (Raibizumab) double-dose;Lucentis® (Raibizumab) regular-dose
11 Safety and Efficacy of Difluprednate 0.05% for the Treatment of Anterior Uveitis Completed NCT01201798 Phase 3 Difluprednate 0.05% ophthalmic emulsion;Prednisolone acetate 1.0% ophthalmic suspension
12 A Multi-center Study to Assess the Efficacy and Safety of LX211 in Active Non-infectious Anterior Uveitis Completed NCT00404885 Phase 3 Placebo;LX211;LX211;LX211
13 Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Non-Infectious Anterior Uveitis Completed NCT02517619 Phase 3 Dexamethasone Phosphate Ophthalmic Solution;Prednisolone Acetate Ophthalmic (1%)
14 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00406887 Phase 3 Difluprednate Ophthalmic Emulsion
15 Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis Completed NCT01505088 Phase 3 40 mg/mL Dexamethasone phosphate ophthalmic solution;Prednisolone Acetate (1%) Eyedrops;100 mM sodium citrate buffer solution;Placebo Eyedrops
16 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Severe Uveitis Completed NCT00407056 Phase 3 Difluprednate Ophthalmic Emulsion
17 Study of Difluprednate in the Treatment of Uveitis Completed NCT00501579 Phase 3 Difluprednate;Prednisolone Acetate
18 Herpetic Eye Disease Study (HEDS) II Completed NCT00000139 Phase 3 Acyclovir
19 Suprachoroidal Injection of CLS-TA in Subjects Non-infectious Uveitis Completed NCT03097315 Phase 3
20 Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis Completed NCT02595398 Phase 3 4mg CLS-TA Suprachoriodal Injection;Sham Procedure
21 CLARITY Extension Study Completed NCT00641537 Phase 3 Cladribine;Placebo;Cladribine;Cladribine;Placebo
22 A Study of Ixekizumab (LY2439821) in bDMARD-Naive Participants With Radiographic Axial Spondyloarthritis Completed NCT02696785 Phase 3 Ixekizumab;Placebo;Adalimumab
23 SOLACE Trial - A Phase 3 Trial in Subjects With Non-infectious Anterior-uveitis. Recruiting NCT03131154 Phase 3 ADX-102 Ophthalmic Solution (0.5%);Vehicle of ADX-102 Ophthalmic Solution
24 Treatment Tapering in JIA With Inactive Disease Recruiting NCT02840175 Phase 3 etanercept;adalimumab;Abatacept;Tocilizumab
25 A Long Term Extension Study of Ixekizumab (LY2439821) in Participants With Axial Spondyloarthritis Active, not recruiting NCT03129100 Phase 3 Ixekizumab;Placebo
26 Multicenter Study Evaluating Certolizumab Pegol Compared to Placebo in Subjects With axSpA Without X-ray Evidence of AS Active, not recruiting NCT02552212 Phase 3
27 A Study of Ixekizumab (LY2439821) in Participants With Nonradiographic Axial Spondyloarthritis Active, not recruiting NCT02757352 Phase 3 Ixekizumab;Placebo
28 A Study of Ixekizumab (LY2439821) in TNF Inhibitor Experienced Participants With Radiographic Axial Spondyloarthritis Active, not recruiting NCT02696798 Phase 3 Ixekizumab;Placebo
29 Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis: Treatment Outcomes Not yet recruiting NCT03586284 Phase 2, Phase 3 Valganciclovir Hydrochloride;Ganciclovir Sodium;Placebo Oral Tablet;Topical placebo
30 Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis Not yet recruiting NCT03576898 Phase 2, Phase 3 Topical ganciclovir versus oral valganciclovir versus placebo
31 Preventing Extension of Oligoarticular Juvenile Idiopathic Arthritis JIA (Limit-JIA) Not yet recruiting NCT03841357 Phase 3 Abatacept Injection
32 A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Anterior Uveitis Terminated NCT00333996 Phase 2, Phase 3 Dexamethasone
33 Proof of Concept Study to Evaluate Safety and Efficacy of LME636 in the Treatment of Acute Anterior Uveitis Completed NCT02482129 Phase 2 LME636 60 mg/mL ophthalmic solution;Dexamethasone 0.1% ophthalmic solution;LME636 Vehicle
34 A Safety and Efficacy Study of NS2 in Patients With Anterior Uveitis Completed NCT02406209 Phase 2 NS2;Prednisolone acetate ophthalmic suspension (1%)
35 Safety and Efficacy Study of DSP-Visulex for the Treatment of Anterior Uveitis Completed NCT02309385 Phase 1, Phase 2 8% Dexamethasone Sodium Phosphate - Visulex;15% Dexamethasone Sodium Phosphate - Visulex;Prednisolone Acetate (1%) Eye Drops
36 Exploratory Study on Topical ESBA105 in Acute Anterior Uveitis Completed NCT00823173 Phase 2
37 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00405496 Phase 2 Difluprednate Ophthalmic Emulsion
38 Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis Completed NCT00130637 Phase 2 Daclizumab
39 Safety and Efficacy Study of Iontophoresis and Dexamethasone Phosphate to Treat Anterior Uveitis Completed NCT00694135 Phase 2 EGP-437 1.6 mA-min at 0.4 with EyeGate® II System;EGP-437 4.8 mA-min at 1.2 mA with EyeGate® II System;EGP-437 10.0 mA-min at 2.5 mA with EyeGate® II System;EGP-437 14.0 mA-min at 3.5 mA with EyeGate® II System
40 Topical Interferon Gamma for Macular Edema Secondary to Uveitis Completed NCT01376362 Phase 1, Phase 2 Interferon Gamma-1b
41 Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis Completed NCT02255032 Phase 2 4 mg CLS-TA;0.8 mg CLS-TA
42 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2 AIN457;AIN 457;AIN457
43 A Phase I/IIa Study for the Treatment of Uveitis With Iontophoresis Withdrawn NCT00499551 Phase 1, Phase 2
44 Subconjunctival Sirolimus for the Treatment of Autoimmune Active Anterior Uveiti Completed NCT00876434 Phase 1 Sirolimus
45 Study to Evaluate GSK3052230 in Combination With Paclitaxel and Carboplatin, or Docetaxel or as Single Agent in Subjects With Solid Malignancies and Deregulated Fibroblast Growth Factor (FGF) Pathway Signaling Completed NCT01868022 Phase 1 GSK3052230;paclitaxel;carboplatin;docetaxel;pemetrexed;cisplatin
46 Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Withdrawn NCT02042027 Phase 1 Gamunex-C
47 Acute Anterior Uveitis: Psychic Burden and Pain Unknown status NCT01156285
48 Clinical Outcomes of Topical Ganciclovir Treatment in Cytomegalovirus Anterior Uveitis Unknown status NCT01486693
49 Variations in Retinal Nerve Fiber Layer Thickness During Uncomplicated Anterior and Intermediate Uveitis Unknown status NCT02879084
50 Etanercept: Single Blind Control Study in Ocular Manifestations of Behcet's Disease Unknown status NCT00931957 Not Applicable Etanercept, Methotrexate, Prednisolone

Search NIH Clinical Center for Anterior Uveitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :
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Genetic Tests for Anterior Uveitis

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Anatomical Context for Anterior Uveitis

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MalaCards organs/tissues related to Anterior Uveitis:

42
Eye, Prostate, Thyroid, Endothelial, T Cells, Lung, Neutrophil
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Publications for Anterior Uveitis

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Articles related to Anterior Uveitis:

(show top 50) (show all 1202)
# Title Authors Year
1
Novel gene targets for miRNA146a and miRNA155 in anterior uveitis. ( 30297336 )
2019
2
Herpetic Anterior Uveitis - Analysis of Presumed and PCR Proven Cases. ( 30311824 )
2019
3
Aqueous Humor Analysis Identifies Higher Branched Chain Amino Acid Metabolism as a Marker for Human Leukocyte Antigen-B27 Acute Anterior Uveitis and Disease Activity. ( 30312576 )
2019
4
Demystifying viral anterior uveitis: A review. ( 30345620 )
2019
5
Novel Dexamethasone Sodium Phosphate Treatment (DSP-Visulex) for Noninfectious Anterior Uveitis: A Randomized Phase I/II Clinical Trial. ( 30354530 )
2019
6
Reduced Occurrence Rate of Acute Anterior Uveitis in Ankylosing Spondylitis Treated with Golimumab - The GO-EASY Study. ( 30385705 )
2019
7
Aqueous tap and rapid diagnosis of cytomegalovirus anterior uveitis: the Reggio Emilia experience. ( 30392022 )
2019
8
Timing of infliximab and adalimumab initiation despite methotrexate in children with chronic non-infectious anterior uveitis. ( 30487588 )
2019
9
BISPHOSPHONATE-INDUCED BILATERAL ANTERIOR UVEITIS AND CHOROIDAL EFFUSIONS WITH SECONDARY ANGLE CLOSURE. ( 30640817 )
2019
10
Chronic Anterior Uveitis in a Patient with CREST Syndrome. ( 30691950 )
2019
11
Inhibitory role of transforming growth factor β2 in experimental autoimmune anterior uveitis. ( 30719689 )
2019
12
Efficacy of anti-tumour necrosis factor-α monoclonal antibodies in patients with non-infectious anterior uveitis. ( 30719968 )
2019
13
Emerging Viral Infections Causing Anterior Uveitis. ( 30794475 )
2019
14
Risk factors associated with persistent anterior uveitis after cataract surgery. ( 30794788 )
2019
15
Preventive effects of tyrosol, a natural phenolic compound, on anterior uveitis induced by anterior chamber paracentesis in healthy beagle dogs. ( 30799325 )
2019
16
Evaluation of choroidal parameters in eyes at the first onset of acute anterior uveitis. ( 30819128 )
2019
17
Epidemiology and clinical features of viral anterior uveitis in southern Taiwan-diagnosis with polymerase chain reaction. ( 30943921 )
2019
18
Treatment of presumed trematode-induced granulomatous anterior uveitis among children in rural areas of Egypt. ( 30944459 )
2019
19
Synbiotic Supplementation May Relieve Anterior Uveitis, an Ocular Manifestation in Behcet's Syndrome. ( 31000688 )
2019
20
Taking care to correctly diagnose viral anterior uveitis. ( 31016856 )
2019
21
Bilateral Papillitis and Anterior Uveitis in a Pediatric Patient. ( 31018054 )
2019
22
Characteristics and Clinical Outcomes of Hypertensive Anterior Uveitis. ( 31020885 )
2019
23
Areas of agreement in the management of childhood non-infectious chronic anterior uveitis in the UK. ( 31048286 )
2019
24
Bilateral Anterior Uveitis Revealing Relapsing Polychondritis ( 31055895 )
2019
25
PCR Multiplex for CMV Detection in Patients with Anterior Uveitis. ( 29474137 )
2019
26
Immunohistochemical characterization of feline lymphoplasmacytic anterior uveitis. ( 29517855 )
2019
27
Clinical features of patients with diabetic anterior uveitis. ( 29563110 )
2019
28
Childhood Arthritis and Rheumatology Research Alliance consensus treatment plans for juvenile idiopathic arthritis-associated and idiopathic chronic anterior uveitis. ( 29806733 )
2018
29
Differential Diagnosis of Viral-Induced Anterior Uveitis. ( 29869892 )
2018
30
Raised intracranial pressure with bilateral anterior uveitis. ( 29891509 )
2018
31
Hypertensive acute granulomatous anterior uveitis as a side effect of topical brimonidine. ( 29910082 )
2018
32
Virus-Induced Anterior Uveitis (VIAU) in Immunocompromised Patients. ( 29969370 )
2018
33
Cytomegalovirus Anterior Uveitis: Clinical Characteristics and Long-term Outcomes in a French Series. ( 30055154 )
2018
34
The effect of methotrexate and sulfasalazine on the course of HLA-B27-positive anterior uveitis: results from a retrospective cohort study. ( 30069748 )
2018
35
Review for Disease of the Year: Treatment of Viral Anterior Uveitis: A Perspective. ( 30096015 )
2018
36
Requirement of longer term antiviral therapy in patients with cytomegalovirus anterior uveitis with corneal endothelial cell damage. ( 30100703 )
2018
37
The Phenotype of Monocytes in Anterior Uveitis Depends on the HLA-B27 Status. ( 30105034 )
2018
38
The Expression of Calprotectin and Factors in TLR4/NF-κB/MyD88 Pathway in Patients with Idiopathic Acute Anterior Uveitis. ( 30111215 )
2018
39
Bilateral anterior uveitis after immunotherapy for malignant melanoma. ( 30294532 )
2018
40
The microbiome and HLA-B27-associated acute anterior uveitis. ( 30301938 )
2018
41
Discovery of tear biomarkers in children with chronic non-infectious anterior uveitis: a pilot study. ( 30327966 )
2018
42
Viral disease of the year: Anterior uveitis. ( 30353994 )
2018
43
The Management of Acute Anterior Uveitis Complicating Spondyloarthritis: Present and Future. ( 30406148 )
2018
44
PD-1 Polymorphisms Are Associated with Susceptibility of Acute Anterior Uveitis in Chinese Population. ( 30540488 )
2018
45
Evaluation of changes in retinal and choroidal thickness using spectral domain optical coherence tomography in unilateral non granulomatous acute anterior uveitis. ( 30600178 )
2018
46
Acute anterior uveitis in spondyloarthritis: a monocentric study of 301 patients. ( 30620268 )
2018
47
Successful Certolizumab Pegol Treatment of Chronic Anterior Uveitis Associated with Psoriasis Vulgaris. ( 30687070 )
2018
48
Genotype-Phenotype Association Study Reveals CFI-Rs13104777 to be a Protective Genetic Marker Against Acute Anterior Uveitis. ( 27380463 )
2018
49
Bilateral Anterior Uveitis Associated with Nivolumab Therapy. ( 27599197 )
2018
50
Choroidal thickness changes determined by EDI-OCT on acute anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis. ( 28197814 )
2018
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Variations for Anterior Uveitis

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Expression for Anterior Uveitis

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Search GEO for disease gene expression data for Anterior Uveitis.
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Pathways for Anterior Uveitis

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Pathways related to Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.65 CFH CTLA4 HLA-B IL2RA IL6 PTPN22
2
Class I MHC mediated antigen processing and presentation 67
Show member pathways
 13.26 CTLA4 HLA-B PTPN22 TLR2 TLR4
3
Akt Signaling 65
Show member pathways
 13.21 IL2RA IL6 TLR2 TLR4 TNF
4
Toll-like Receptor Signaling Pathway 1 38
Show member pathways
 12.92 IL6 TLR2 TLR4 TNF
5
Human cytomegalovirus infection 38
Show member pathways
 12.79 HLA-B IL6 TLR2 TLR4 TNF
6
Allograft rejection 38 1
Show member pathways
 12.7 CTLA4 HLA-B IL2RA IL6 TNF
7
PI3K-Akt signaling pathway 38
Show member pathways
 12.63 HLA-B IL2RA IL6 TLR2 TLR4 TNF
8
NF-KappaB Family Pathway 65
Show member pathways
 12.54 IL6 TLR2 TLR4 TNF
9
T cell receptor signaling pathway 38
Show member pathways
 12.4 CTLA4 IL6 TNF
10
Th17 cell differentiation 38
Show member pathways
 12.37 IL2RA IL6 TLR2 TLR4 TNF
11
NF-kappaB Signaling 4
12.28 CTLA4 IL2RA PTPN22 TLR2 TNF
12
Human T-cell leukemia virus 1 infection 38
12.22 HLA-B IL2RA IL6 TNF
13
IL-17 Family Signaling Pathways 66
Show member pathways
 12.17 IL6 TLR2 TNF
14
Toll Comparative Pathway 65
Show member pathways
 12.16 IL6 TLR4 TNF
15
Proteoglycans in cancer 38
12.14 TLR2 TLR4 TNF
16
Diseases associated with the TLR signaling cascade 67
Show member pathways
 12.13 IL6 TLR2 TLR4 TNF
17
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.12 HLA-B IL2RA IL6 TNF
18
Toxoplasmosis 38
Show member pathways
 12.1 TLR2 TLR4 TNF
19
Tuberculosis 38
12.09 IL6 TLR2 TLR4 TNF
20
IL-1 Family Signaling Pathways 66
Show member pathways
 12.07 IL6 TLR2 TNF
21
Bacterial infections in CF airways 23
Show member pathways
 12.03 IL6 TLR2 TLR4 TNF
22
Colorectal Cancer Metastasis 65
12.01 IL6 TLR2 TLR4 TNF
23
Phagosome 38
12 HLA-B TLR2 TLR4
24
MAPK Pathway 73
Show member pathways
 11.9 IL2RA TLR2 TLR4
25
Th1 Differentiation Pathway 66
Show member pathways
 11.89 IL6 TLR2 TLR4 TNF
26
Spinal Cord Injury 1
11.88 IL6 TLR4 TNF
27
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.86 IL2RA IL6 TNF
28
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 11.86 IL6 TLR2 TLR4 TNF
29
Hematopoietic cell lineage 38
11.77 IL2RA IL6 TNF
30
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.65 CTLA4 IL2RA TNF
31
Pertussis 38
11.64 IL6 TLR4 TNF
32
Amoebiasis 38
11.54 IL6 TLR2 TLR4 TNF
33
MSP-RON Signaling 65
11.42 TLR2 TLR4 TNF
34
African trypanosomiasis 38
11.25 IL6 TNF
35
IL-10 Pathway 65
11.24 IL6 TLR4 TNF
36
Legionellosis 38
11.2 IL6 TLR2 TLR4 TNF
37
Development and heterogeneity of the ILC family 1
11.18 IL6 TNF
38
Antifolate resistance 38
11.16 IL6 TNF
39
Cytokines and Inflammatory Response 1
11.12 IL6 TNF
40
Transcription factor regulation in adipogenesis 1
10.99 IL6 TNF
41
Rheumatoid arthritis 38
10.98 CTLA4 IL6 TLR2 TLR4 TNF
42
Malaria 38
10.95 IL6 TLR2 TLR4 TNF
43
Overview of nanoparticle effects 1
10.92 IL6 TNF
Sources

GO Terms for Anterior Uveitis

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Cellular components related to Anterior Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.55 CTLA4 HLA-B TLR2 TLR4 TNF
2 intrinsic component of plasma membrane GO:0031226 9.26 TLR2 TLR4
3 external side of plasma membrane GO:0009897 9.26 CTLA4 IL2RA TLR4 TNF
4 cell surface GO:0009986 9.02 HLA-B IL2RA TLR2 TLR4 TNF

Biological processes related to Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.87 IL6 TLR2 TLR4 TNF
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.83 PTPN22 TLR4 TNF
3 positive regulation of gene expression GO:0010628 9.83 IL6 PTPN22 TLR2 TLR4 TNF
4 response to lipopolysaccharide GO:0032496 9.8 PTPN22 TLR2 TLR4
5 cellular response to lipopolysaccharide GO:0071222 9.8 IL6 TLR4 TNF
6 immune system process GO:0002376 9.8 CTLA4 HLA-B IL2RA PTPN22 TLR2 TLR4
7 defense response to Gram-positive bacterium GO:0050830 9.71 IL6 TLR2 TNF
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.71 IL6 TLR2 TLR4 TNF
9 positive regulation of inflammatory response GO:0050729 9.69 TLR2 TLR4 TNF
10 toll-like receptor signaling pathway GO:0002224 9.66 TLR2 TLR4
11 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.65 TLR2 TLR4
12 negative regulation of interleukin-6 production GO:0032715 9.65 TLR4 TNF
13 positive regulation of interferon-beta production GO:0032728 9.65 TLR2 TLR4
14 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.65 TLR2 TLR4 TNF
15 negative regulation of neurogenesis GO:0050768 9.64 IL6 TNF
16 positive regulation of interleukin-12 production GO:0032735 9.64 TLR2 TLR4
17 positive regulation of interleukin-10 production GO:0032733 9.63 TLR2 TLR4
18 microglial cell activation GO:0001774 9.62 TLR2 TNF
19 positive regulation of glial cell proliferation GO:0060252 9.61 IL6 TNF
20 regulation of regulatory T cell differentiation GO:0045589 9.61 CTLA4 IL2RA
21 negative regulation of immune response GO:0050777 9.6 CTLA4 IL2RA
22 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.59 TLR2 TLR4
23 regulation of cytokine secretion GO:0050707 9.58 TLR2 TLR4
24 I-kappaB phosphorylation GO:0007252 9.58 TLR2 TLR4
25 cellular response to lipoteichoic acid GO:0071223 9.56 TLR2 TLR4
26 positive regulation of interleukin-6 production GO:0032755 9.56 IL6 TLR2 TLR4 TNF
27 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.55 TLR4 TNF
28 positive regulation of interleukin-8 production GO:0032757 9.54 TLR2 TLR4 TNF
29 negative regulation of lipid storage GO:0010888 9.52 IL6 TNF
30 positive regulation of neuroinflammatory response GO:0150078 9.49 IL6 TNF
31 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.46 TLR2 TLR4
32 lipopolysaccharide-mediated signaling pathway GO:0031663 9.46 PTPN22 TLR2 TLR4 TNF
33 positive regulation of chemokine production GO:0032722 9.26 IL6 TLR2 TLR4 TNF
34 immune response GO:0006955 9.17 CTLA4 HLA-B IL2RA IL6 TLR2 TLR4

Molecular functions related to Anterior Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.96 TLR2 TLR4
2 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4
Sources

Sources for Anterior Uveitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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