Anterior Uveitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ANT034 MIFTS: 56	Anterior Uveitis Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Anterior Uveitis

MalaCards integrated aliases for Anterior Uveitis:

Name: Anterior Uveitis ¹¹ ¹⁹ ⁵⁸ ¹⁴ ¹⁶ ⁷¹ ³³

Iridocyclitis ¹⁹ ⁵⁸ ⁷¹ ³³

Uveitis, Anterior ⁷⁵ ⁴³

Intraocular Inflammation ³³

Acute Anterior Uveitis ⁷¹

Anterior Chamber Cell ³³

Uveal Inflammation ³³

Kerato-Uveitis ³³

Uveokeratitis ³³

Keratouveitis ³³

Keratoiritis ³³

Uveitis Nos ³³

Cyclitis ³³

Iritis ³³

Characteristics:

Prevelance:

>1/1000 (Denmark) ⁵⁸

Age Of Onset:

All ages ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases Neuronal diseases Immune diseases

See all MalaCards categories (disease lists)

ICD11: ³³

Diseases of the visual system

Disorders of the eyeball - anterior segment

Disorders of the anterior uvea

Anterior uveitis

Anterior uveitis, unspecified

Other specified anterior uveitis

Primary anterior uveitis

Orphanet: ⁵⁸

Rare eye diseases

External Ids:

Disease Ontology ¹¹ DOID:1407

MeSH ⁴³ D014606

NCIt ⁴⁹ C35109

SNOMED-CT ⁶⁸ 193500005

UMLS via Orphanet ⁷² C0022073 C0042165

Orphanet ⁵⁸ ORPHA280886

EFO ¹⁶ EFO_1000811

ICD11 ³³ 682103962 908233081 908233081/other more

UMLS ⁷¹ C0022073 C0042165 C0701807

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Summaries for Anterior Uveitis

GARD: ¹⁹ Inflammation of the anterior uvea comprising the iris, angle structures, and the ciliary body. Manifestations of this disorder include ciliary injection, exudation into the anterior chamber, iris changes, and adhesions between the iris and lens (posterior synechiae). Intraocular pressure may be increased or reduced.

MalaCards based summary: Anterior Uveitis, also known as iridocyclitis, is related to infectious anterior uveitis and glaucomatocyclitic crisis. An important gene associated with Anterior Uveitis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Wikipedia: ⁷⁵ Uveitis (/ˌjuːvɪaɪtɪs/) is inflammation of the uvea, the pigmented layer of the eye between the inner... more...

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Related Diseases for Anterior Uveitis

Diseases in the Uveitis family:

Autoimmune Uveitis	Posterior Uveitis
Intermediate Uveitis	Anterior Uveitis
Infectious Anterior Uveitis	Infectious Posterior Uveitis
Systemic Diseases with Anterior Uveitis	Systemic Diseases with Posterior Uveitis

Diseases related to Anterior Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1338)

#	Related Disease	Score	Top Affiliating Genes
1	infectious anterior uveitis	32.7	TNF IL17A
2	glaucomatocyclitic crisis	32.2	MRAP HLA-B
3	uveoparotid fever	32.1	CD4 ACE
4	uveitis	31.9	TNF RBP3 IL6 IL23R IL1B IL17A
5	blau syndrome	31.7	TNF TLR4 TLR2 IL1B IL10
6	sympathetic ophthalmia	31.4	TNF SERPINA3 RBP3 IL17A IL10 CD4
7	posterior uveitis	31.2	TNF RBP3 IL6 IL17A ICOSLG HLA-B
8	fuchs' heterochromic uveitis	31.2	IL6 IL10 ACE
9	macular retinal edema	31.2	TNF IL6 IL1B ACE
10	scleritis	31.2	TNF CRP CCR6
11	pars planitis	31.1	RBP3 HLA-B CCR6 ACE
12	macular dystrophy, dominant cystoid	31.0	TNF RBP3 IL6 ACE
13	conjunctivitis	30.9	TNF TLR4 IL6 IL10 HLA-B
14	herpes zoster	30.9	TLR2 IL10 HLA-B CD8A CD4 CCR6
15	psoriasis 1	30.9	IL23R IL17A CCR6
16	iritis	30.8	TNF RBP3 IL6 IL17A IL10 HLA-B
17	retinal vasculitis	30.8	TNF RBP3 CD4 CCR6 ACE
18	spondylarthropathy	30.8	TNF TLR4 TLR2 CRP
19	reactive arthritis	30.7	TNF MRAP IL17A HLA-B ERAP1 CRP
20	corneal ulcer	30.7	TNF IL6 IL1B
21	arthropathy	30.7	TNF IL6 IL1B CRP CCR6
22	juvenile rheumatoid arthritis	30.7	TNF SERPINA3 IL6 IL1B ICOSLG CRP
23	back pain	30.7	IL6 IL1B IL10 CRP
24	spondylitis	30.6	TNF IL6 IL23R IL1B IL17A IL10
25	rubella	30.6	TNF TLR4 IL6 IL1B IL10 HLA-B
26	relapsing polychondritis	30.6	TNF IL6 CRP CD4
27	posterior scleritis	30.6	TNF CRP ACE
28	ocular tuberculosis	30.6	RBP3 CD4 ACE
29	retinal vascular occlusion	30.5	TNF SERPINA3 IL6 CRP
30	neuroretinitis	30.5	CRP CD4 ACE
31	neuritis	30.5	TNF IL6 IL1B IL10
32	iridocyclitis	30.5	TNF RBP3 MRAP IL6 IL1B IL17A
33	optic papillitis	30.5	TNF RBP3 MRAP CRP CD4 ACE
34	sclerosing keratitis	30.5	RBP3 CRP
35	chikungunya	30.4	TNF IL6 IL1B IL17A CRP
36	endophthalmitis	30.4	TNF TLR2 RBP3 IL6 IL1B CRP
37	cytomegalovirus retinitis	30.4	TNF IL10 HLA-B CD8A CD4
38	toxoplasmosis	30.4	TNF IL6 IL1B IL17A IL10
39	interstitial nephritis	30.3	TNF ICOSLG CRP CD8A CD4 CCR6
40	choroiditis	30.3	TNF RBP3 IL17A IL10 CRP CD4
41	optic neuritis	30.3	TNF IL6 IL1B IL10 HLA-B
42	intermediate uveitis	30.3	TNF RBP3 IL6 IL17A CD4 CCR6
43	iga glomerulonephritis	30.3	IL6 CFHR2 CCR6 ACE
44	osteoarthritis	30.3	TNF IL6 IL1B IL17A CRP
45	keratoconjunctivitis sicca	30.3	TNF ICOSLG CD4 CCR6
46	bowel dysfunction	30.3	TNF IL6 IL1B IL10 CRP ACE
47	mumps	30.3	TNF IL6 IL1B IL10
48	toxocariasis	30.3	IL6 IL10 CRP ACE
49	histiocytosis	30.2	TNF SERPINA3 IL17A CCR6
50	panophthalmitis	30.2	RBP3 CRP CD4

Graphical network of the top 20 diseases related to Anterior Uveitis:

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Symptoms & Phenotypes for Anterior Uveitis

GenomeRNAi Phenotypes related to Anterior Uveitis according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.17	ACE CCR6 CD4 CD8A CFHR2 CRP
2	no effect	GR00402-S-2	10.17	ACE CCR6 CD4 CFHR2 CRP ERAP1

MGI Mouse Phenotypes related to Anterior Uveitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.31	ACE CCR6 CD4 CRP ERAP1 ICOSLG
2	endocrine/exocrine gland	MP:0005379	10.15	ACE CD4 CD8A ERAP1 HLA-B IL10
3	liver/biliary system	MP:0005370	10.09	ACE ERAP1 IL10 IL17A IL6 MRAP
4	immune system	MP:0005387	10.09	ACE CCR6 CD4 CD8A CRP ERAP1
5	neoplasm	MP:0002006	10.08	ACE IL10 IL1B IL23R IL6 TLR2
6	no phenotypic analysis	MP:0003012	10	CD4 ERAP1 HLA-B IL10 IL17A IL23R
7	cardiovascular system	MP:0005385	10	ACE CCR6 CRP HLA-B IL10 IL1B
8	digestive/alimentary	MP:0005381	9.97	CD4 HLA-B IL10 IL17A IL23R IL6
9	hematopoietic system	MP:0005397	9.86	ACE CCR6 CD4 CD8A ERAP1 HLA-B
10	integument	MP:0010771	9.36	CD4 CD8A IL10 IL17A IL1B IL6

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Drugs & Therapeutics for Anterior Uveitis

Drugs for Anterior Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 104)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4

1177-87-3

3680

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4

50-02-2

3003 5743

Triamcinolone

Approved, Vet_approved

Phase 4

124-94-7

31307

Lidocaine

Approved, Vet_approved

Phase 4

137-58-6

3676

Tobramycin

Approved, Investigational

Phase 4

32986-56-4

36294

Certolizumab pegol

Approved

Phase 4

428863-50-7

Bimatoprost

Approved, Investigational

Phase 4

155206-00-1

5311027

Latanoprost

Approved, Investigational

Phase 4

130209-82-4

5311221 5282380

Travoprost

Approved

Phase 4

157283-68-6

5282226

Timolol

Approved

Phase 4

26839-75-8

5478 33624

Ganciclovir

Approved, Investigational

Phase 4

82410-32-0

3454

Adalimumab

Approved, Experimental

Phase 4

331731-18-1

Levoleucovorin

Approved, Experimental, Investigational

Phase 4

68538-85-2, 58-05-9, 73951-54-9

149436 6006

Methotrexate

Approved

Phase 4

1959-05-2, 59-05-2

4112 126941

Fluocinolone acetonide

Approved, Investigational, Vet_approved

Phase 4

67-73-2

6215

Folic acid

Approved, Nutraceutical, Vet_approved

Phase 4

59-30-3

6037

Maleic acid

Experimental, Investigational

Phase 4

110-16-7, 110-17-8

444266 444972

Triamcinolone hexacetonide

Phase 4

Triamcinolone diacetate

Phase 4

Triamcinolone Acetonide

Phase 4

6436

Anesthetics

Phase 4

Gentamicins

Phase 4

Pharmaceutical Solutions

Phase 4

Anticoagulants

Phase 4

Blood Substitutes

Phase 4

Adrenergic beta-Antagonists

Phase 4

Adrenergic Antagonists

Phase 4

Adrenergic Agents

Phase 4

Anti-Arrhythmia Agents

Phase 4

Antihypertensive Agents

Phase 4

Lubricant Eye Drops

Phase 4

Plasma Substitutes

Phase 4

Dextrans

Phase 4

Immunosuppressive Agents

Phase 4

Immunologic Factors

Phase 4

Ophthalmic Solutions

Phase 4

Antiviral Agents

Phase 4

Anti-Infective Agents

Phase 4

Ganciclovir triphosphate

Phase 4

Folic Acid Antagonists

Phase 4

Folate

Phase 4

Vitamin B9

Phase 4

Vitamin B Complex

Phase 4

Antimetabolites

Phase 4

Melanocyte-Stimulating Hormones

Phase 4

Adrenocorticotropic Hormone

Phase 4

beta-Endorphin

Phase 4

Difluprednate

Approved

Phase 3

23674-86-4

443936

Sodium citrate

Approved, Investigational

Phase 3

68-04-2

23431961

Loteprednol etabonate

Approved, Experimental

Phase 3

82034-46-6, 129260-79-3

22227703 9865442 444025

Interventional clinical trials:

(show top 50) (show all 67)

#	Name	Status	NCT ID	Phase	Drugs
1	Evaluation of DEXTENZA on the Management of Pain and Inflammation in Patients With Anterior Uveitis Compared to Standard of Care Topical Corticosteroids	Unknown status	NCT04426734	Phase 4	Topical Prednisolone Acetate 1%
2	Quantitative Comparison of the Efficacy of Subtenon 20-mg Triamcinolone Injection With 0.1% Dexamethasone Eye Drop in Controlling Intraocular Inflammation After Phacoemulsification	Unknown status	NCT01801774	Phase 4	Subtenon 20-mg triamcinolone injection;Placebo
3	Multicenter, Open-Label Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis Flares in Axial Spondyloarthritis Subjects With a History of Anterior Uveitis (C-VIEW)	Completed	NCT03020992	Phase 4	Certolizumab Pegol
4	Prospective Open Label Study of H.P. Acthar Gel Injection in Patients With Active Non-Infectious Uveitis With Associated Glaucoma Thus High Frequency Regional Corticosteroid and Oral Corticosteroids Cause Intolerable Side-Effects	Completed	NCT02764697	Phase 4	H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
5	Blood-aqueous Barrier Changes After the Use of Timolol and Prostaglandin Analogues Fixed Combination in Pseudophakic Patients With Primary Open Angle Glaucoma	Completed	NCT01978015	Phase 4	travoprost and timolol maleate fixed combination;latanoprost and maleate timolol fixed combination;bimatoprost and timolol maleate fixed combination;dextran and hypromellose
6	Multi-center, Randomized, Double Masked, Vehicle Controlled Phase IV Study to Compare the Efficacy, Ocular Safety and Tolerability of a Two Day Treatment With Eye Drops (0.5% Prednisolone Acetate, One Drop Four Times Per Day) in Patients With Intraocular Inflammation After Cataract Surgery, Followed by an Open Label Observational Period of 12 Days	Completed	NCT00170729	Phase 4	Prednisolone acetate
7	Intra-cameral Penetration and Efficacy of Ganciclovir Following Topical Administration of 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis	Recruiting	NCT02943057	Phase 4	2% guttae ganciclovir
8	The Efficacy and Safety of Adalimumab for Inflammatory Flare Prevention in Non-infectious Anterior Pediatric Uveitis With Peripheral Vascular Leakage Compared With Methotrexate, a RCT Study	Recruiting	NCT05015335	Phase 4	Adalimumab;Methotrexate
9	Phase 4 Study of YUTIQ® (Fluocinolone Acetonide Intravitreal Implant) 0.18 mg in the Treatment of Chronic Non-Infectious Posterior Segment Uveitis (Intraocular Inflammation Study)	Recruiting	NCT05322070	Phase 4	Fluocinolone Acetonide Intravitreal Implant 0.18 mg
10	Prospective Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis Who Are Not Well Controlled With, or Intolerant of, Topical or Systemic Corticosteroids	Terminated	NCT02769702	Phase 4	Acthar
11	Phase 3 Confirmatory Study of 0.05% Difluprednate Ophthalmic Emulsion in the Treatment of Anterior Uveitis (Including Panuveitis).	Completed	NCT00406887	Phase 3	Difluprednate Ophthalmic Emulsion
12	A Phase 3, Randomized, Double-masked, Vehicle-controlled Trial to Evaluate the Safety and Efficacy of ADX-102 Ophthalmic Solution in Subjects With Non-infectious Anterior-uveitis.	Completed	NCT03131154	Phase 3	ADX-102 Ophthalmic Solution (0.5%);Vehicle of ADX-102 Ophthalmic Solution
13	A Prospective, Multi-Center, Randomized, Double-Masked, Positive Controlled, Phase 3 Clinical Trial Designed to Evaluate the Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution Compared to Prednisolone Acetate Ophthalmic Suspension (1%) in Patients With Non-Infectious Anterior Segment Uveitis	Completed	NCT02517619	Phase 3	Dexamethasone Phosphate Ophthalmic Solution;Prednisolone Acetate Ophthalmic (1%)
14	A Phase 3 Multicenter, Randomized, Double-Masked Study of the Safety and Efficacy of Difluprednate 0.05% Ophthalmic Emulsion Compared to Prednisolone Acetate 1% Ophthalmic Suspension in the Treatment of Endogenous Anterior Uveitis	Completed	NCT01201798	Phase 3	Difluprednate 0.05% ophthalmic emulsion;Prednisolone acetate 1.0% ophthalmic suspension
15	A Prospective, Multi-Center, Randomized, Double-Masked, Positive-Controlled Phase 3 Clinical Trial Designed to Evaluate the Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution Compared to Prednisolone Acetate Ophthalmic Suspension (1%) in Patients With Non-Infectious Anterior Segment Uveitis	Completed	NCT01505088	Phase 3	40 mg/mL Dexamethasone phosphate ophthalmic solution;Prednisolone Acetate (1%) Eyedrops;100 mM sodium citrate buffer solution;Placebo Eyedrops
16	Phase 3 Open-Labeled Study of 0.05% Difluprednate Ophthalmic Emulsion in the Treatment of Severe Anterior Uveitis (Including Panuveitis).	Completed	NCT00407056	Phase 3	Difluprednate Ophthalmic Emulsion
17	A Double-Masked, Placebo-Controlled, Parallel-Group, Multi-Center, Dose-Ranging Study With an Optional Extension to Assess the Efficacy and Safety of LX211 as Therapy in Subjects With Active Sight Threatening, Non-infectious Anterior Uveitis	Completed	NCT00404885	Phase 3	Placebo;LX211
18	A Phase 3, Randomized, Masked, Controlled Clinical Trial to Study the Safety and Efficacy of Triamcinolone Acetonide Injectable Suspension (CLS-TA) for the Treatment of Subjects With Macular Edema Associated With Non-infectious Uveitis	Completed	NCT02595398	Phase 3	4mg CLS-TA Suprachoriodal Injection;Sham Procedure
19	Open-label Safety Study of Suprachoroidal Triamcinolone Acetonide Injectable Suspension in Patients With Non-Infectious Uveitis	Completed	NCT03097315	Phase 3	4 mg CLS-TA Suprachoriodal Injection
20	Intravitreal Bevacizumab for the Treatment of Neovascular Membranes in Patients With Intraocular Inflammation	Completed	NCT00407121	Phase 3	Bevacizumab
21	A Multicenter, Randomized, Double-masked, Vehicle-controlled, Parallel Group Phase III Study of the Efficacy and Safety of a Single Sub-conjunctival Injection of XG-102 for the Reduction of Post-cataract Surgery Intraocular Inflammation	Completed	NCT02508337	Phase 3	XG-102;Placebo
22	Safety and Efficacy of Topical Loteprednol Etabonate 0.5%, Versus Prednisolone Acetate 1%, for the Treatment of Intraocular Inflammation Following Surgery for Childhood Cataract	Completed	NCT01475643	Phase 3	Loteprednol etabonate;Prednisolones acetate
23	A Multicenter, Randomized, Double-masked, Vehicle-controlled, Parallel Group Phase III Study of the Efficacy and Safety of a Single Sub-conjunctival Injection of XG-102 for the Reduction of Post-cataract Surgery Intraocular Inflammation	Completed	NCT02235272	Phase 3	XG-102;Placebo
24	A Phase 3 Randomized, Active-Controlled, Double-Masked Study to Evaluate the Safety and Efficacy of TRS01 Eye Drops in the Treatment of Subjects With Active Non-infectious Anterior Uveitis Including Subjects With Uveitic Glaucoma	Recruiting	NCT05042609	Phase 3	TRS01;FDA approved steroid eye drop
25	Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis: Treatment	Recruiting	NCT03586284	Phase 2, Phase 3	Valganciclovir Hydrochloride;Ganciclovir Sodium;Placebo Oral Tablet;Topical placebo
26	Efficacy, Safety and Cost-effectiveness of Methotrexate, Adalimumab, or Their Combination in Non-infectious Non-anterior Uveitis: a Randomized, Parallel 3 Arms, Active-controlled, Phase 3 Open Label With Blinded Outcome Assessment Study	Recruiting	NCT04798755	Phase 3	Methotrexate;Adalimumab;Adalimumab+Methotrexate
27	The Use of Two YUTIQ Versus Sham for Treatment of Chronic Non Infectious Intraocular Inflammation Affecting the Posterior Segment (TYNI Trial)	Recruiting	NCT05486468	Phase 3	Yutiq 0.18 MG Drug Implant
28	Multicenter, Randomized Study Evaluating the Value of Antitubercular Treatment During Recurent Anterior Uveitis (URBA)	Not yet recruiting	NCT04117698	Phase 3	Antitubercular treatment (RIFATER ©);Ethambutol;RIFINAH ©
29	A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Anterior Uveitis	Terminated	NCT00333996	Phase 2, Phase 3	Dexamethasone
30	A Randomized, Parallel Group, Double-masked, Active-controlled Phase 1/2 Clinical Trial to Evaluate the Efficacy and Safety of Dexamethasone Sodium Phosphate Visulex System for the Treatment of Non-infectious Anterior Uveitis	Completed	NCT02309385	Phase 1, Phase 2	8% Dexamethasone Sodium Phosphate - Visulex;15% Dexamethasone Sodium Phosphate - Visulex;Prednisolone Acetate (1%) Eye Drops
31	A Randomized, Double-Masked, Dose-Ranging Study to Evaluate the Safety and Tolerability of TRS01 Eye Drops in Participants With Active Non-infectious Anterior Uveitis.	Completed	NCT04222712	Phase 1, Phase 2	TRS01 eye drops
32	An Open Label Exploratory Study to Assess the Safety, Tolerability and Clinical Activity of Topically Applied ESBA105 in Patients With Acute Anterior Uveitis	Completed	NCT00823173	Phase 2
33	Phase 2a Study of 0.05% Difluprednate Ophthalmic Emulsion in the Treatment of Anterior Uveitis (Inluding Iritis, Cyclitis, Iridocyclitis, and Panuveitis).	Completed	NCT00405496	Phase 2	Difluprednate Ophthalmic Emulsion
34	Treatment of Active Anterior Uveitis Associated With JIA, Using Humanized Anti-Tac (HAT, Daclizumab)	Completed	NCT00130637	Phase 2	Daclizumab
35	A Phase 2 Randomized, Investigator-Masked, Comparator-controlled Trial to Evaluate the Safety and Efficacy of NS2 Eye Drops in Patients With Anterior Uveitis	Completed	NCT02406209	Phase 2	NS2;Prednisolone acetate ophthalmic suspension (1%)
36	A Multicenter, Randomized, Double-Masked, Active-Controlled Study to Evaluate the Safety and Efficacy of LME636 in Patients With Acute Anterior Uveitis	Completed	NCT02482129	Phase 2	LME636 60 mg/mL ophthalmic solution;Dexamethasone 0.1% ophthalmic solution;LME636 Vehicle
37	The Treatment of Macular Edema Secondary to Uveitis Using Topical Interferon Gamma	Completed	NCT01376362	Phase 1, Phase 2	Interferon Gamma-1b
38	A Randomized, Masked, Multicenter Study to Assess the Safety and Efficacy of CLS-TA, Triamcinolone Acetonide Injectable Suspension in the Treatment of Subjects With Macular Edema Following Uveitis	Completed	NCT02255032	Phase 2	4 mg CLS-TA;0.8 mg CLS-TA
39	A Prospective, Multi-Center, Randomized, Double-Masked, Safety, Tolerability and Efficacy Study of Four Iontophoretic Doses of Dexamethasone Phosphate Ophthalmic Solution in Patients With Non-Infectious Anterior Segment Uveitis	Completed	NCT00694135	Phase 2	EGP-437 1.6 mA-min at 0.4 with EyeGate® II System;EGP-437 4.8 mA-min at 1.2 mA with EyeGate® II System;EGP-437 10.0 mA-min at 2.5 mA with EyeGate® II System;EGP-437 14.0 mA-min at 3.5 mA with EyeGate® II System
40	Pilot Study for the Evaluation of Intravitreal Infliximab in the Treatment of Uveitic Macular Edema	Withdrawn	NCT00958906	Phase 1, Phase 2	Infliximab (intravitreal, 2.0mg/0.05ml)
41	Subconjunctival Sirolimus for the Treatment of Autoimmune Active Anterior Uveitis	Completed	NCT00876434	Phase 1	Sirolimus
42	Pilot Project: The Amplicon and Metatranscriptomic Next-generation Sequencing of Samples From Intra and Extra-intestinal Microbiome in Non-infectious Uveitis Patients to Decipher Possibility Uveitis Pathogenesis	Unknown status	NCT04126850
43	Quality of Life and Visual Function in Uveitis Patients	Unknown status	NCT00407316
44	Acute Anterior Uveitis: Psychic Burden and Pain	Unknown status	NCT01156285
45	Clinical Outcomes of Topical Ganciclovir Treatment in Cytomegalovirus Anterior Uveitis	Unknown status	NCT01486693
46	Pathogen Detection in Infectious Uveitis in China	Unknown status	NCT04521673
47	The Contribution of Altered Aqueous Dynamics in the Development of Raised Intraocular Pressure in Patients With Uveitis	Completed	NCT02765308
48	Ocular Sarcoidosis Open Label Trial of ACTHAR Gel	Completed	NCT02725177		Repository Corticotropin Injection;Repository Corticotropin Injection -Treatment Extension
49	Retinal Optical Coherence Tomography and Multifocal Electroretinogram; Establishing Normal Ranges Related to Age and Reproductive Factors; With the Use of Anti-inflammatory Medications;In Uncomplicated Anterior Uveitis; Anatomy and Function.	Completed	NCT00476593		Diclofenac;Dexamethasone
50	Intra-cameral Penetration of Ganciclovir Following Topical Administration of 0.15% Ganciclovir Gel (VIRGAN©) for CMV Anterior Uveitis / Endotheliitis	Completed	NCT01647529		Ganciclovir

Search NIH Clinical Center for Anterior Uveitis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

rimexolone

Scopolamine

Scopolamine Hydrobromide

Tropicamide

Cochrane evidence based reviews: uveitis, anterior

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Genetic Tests for Anterior Uveitis

Sources

Anatomical Context for Anterior Uveitis

Organs/tissues related to Anterior Uveitis:

MalaCards : Eye, Retina, Endothelial, T Cells, Lymph Node, Neutrophil, Bone Marrow

Sources

Publications for Anterior Uveitis

Articles related to Anterior Uveitis:

(show top 50) (show all 8904)

#	Title	Authors	PMID	Year
1	Changes in Toll-like receptor (TLR)-2 and TLR4 expression and function but not polymorphisms are associated with acute anterior uveitis. ⁵³ ⁶²	Chang JH...Wakefield D	17389503	2007
2	Fecal calprotectin levels in acute anterior uveitis in patients with spondyloarthritis. ⁶²	Gazim CC...Skare TL	35170654	2023
3	Cardiovascular and disease-related features associated with extra-articular manifestations in axial spondyloarthritis. A multicenter study of 888 patients. ⁶²	Rueda-Gotor J...Gonzalez-Gay MA	36150319	2022
4	Certolizumab Pegol Treatment in Patients with Axial-Spondyloarthritis-Associated Acute Anterior Uveitis: a Narrative Review. ⁶²	van der Horst-Bruinsma IE...Deodhar A	36178585	2022
5	Snowball-associated ocular injury - An unusual presentation. ⁶²	Sanjay S...Durgalaxmi M	36453380	2022
6	Safety of intravitreal metoprolol in eyes with central serous chorioretinopathy. ⁶²	Goncalves AN...Jorge R	36333649	2022
7	Topical interferon therapy in uveitic macular edema. ⁶²	Kawali A...Shetty R	36453344	2022
8	COVID-19 vaccination and recurrent anterior uveitis. ⁶²	Sanjay S...Shetty R	36453363	2022
9	Comparison of metabolic profiles in aqueous humour of Fuchs' syndrome and presumed viral-induced anterior uveitis patients. ⁶²	Ding J...Yang P	35849327	2022
10	Alternative Biologic Therapy in Children Failing Conventional TNFα Inhibitors for Refractory, Noninfectious, Chronic Anterior Uveitis. ⁶²	Miraldi Utz V...Kaufman AH	35863492	2022
11	Serum Maresin 1 levels in idiopathic acute anterior uveitis patients. ⁶²	Gul FC...Akkoc RF	36319522	2022
12	Risk for uveitis relapse after COVID-19 vaccination. ⁶²	Zhong Z...Yang P	36209692	2022
13	Argon laser photocoagulation for treatment of presumed trematode-induced granulomatous anterior uveitis in children. ⁶²	Alsmman AH...Abozaid M	36414261	2022
14	COMPARISON OF PRIMARY AND SECONDARY FORMS OF MULTIPLE EVANESCENT WHITE DOT SYNDROME. ⁶²	Serrar Y...Mathis T	36394891	2022
15	A case of intraocular inflammation after intravitreal brolucizumab injection monitored by laser flare-cell photometer. ⁶²	Saito M...Kudo A	36281264	2022
16	Multimodal imaging in the diagnosis and management of ophthalmia nodosa. ⁶²	Ashkenazy N...Davis JL	36324631	2022
17	Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2. ⁶²	Hu X...Wei L	36335665	2022
18	Roles of CCL2 and CCL3 in intraocular inflammation during Bacillus endophthalmitis. ⁶²	Mursalin MH...Callegan MC	36063964	2022
19	Ocular lesions of captive cephalopods. ⁶²	Fiddes K...LaDouceur EEB	36321800	2022
20	Evaluation of efficacy of intracameral lidocaine and tropicamide injection in manual small-incision cataract surgery: A prospective clinical study. ⁶²	Bhat KT...Heda AS	36308110	2022
21	Clinical features and long-term treatment outcome of posterior scleritis. ⁶²	Lee DH...Kim M	36467362	2022
22	OCULAR INJURIES ASSOCIATED WITH ELASTIC EXERCISE BANDS. ⁶²	Ng CC...McDonald HR	33165305	2022
23	Complications of manual small-incision cataract surgery. ⁶²	Goel R...Gaonker T	36308100	2022
24	Therapeutic Potential of d-MAPPS™ for Ocular Inflammatory Diseases and Regeneration of Injured Corneal and Retinal Tissue. ⁶²	Harrell CR	36362313	2022
25	Six-month outcomes of infliximab and tocilizumab therapy in non-infectious retinal vasculitis. ⁶²	Karaca I...Nguyen QD	36443499	2022
26	Iridian anterior segment OCT in rubella uveitis syndrome and cytomegalovirus anterior uveitis: a comparative study. ⁶²	Escribano Lopez P...Gonzalez Guijarro JJ	35708847	2022
27	Bilateral anterior uveitis following paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 - Case report and focused review. ⁶²	Vienne-Jumeau A...Debieb A	36383060	2022
28	Fluocinolone acetonide 0.19-mg implant for the treatment of noninfectious uveitis with involvement of the posterior segment: a real-world study. ⁶²	Buhl L...Kern C	36399176	2022
29	Epidemiology and characteristics of common forms of anterior uveitis at initial presentation in a tertiary facility in Japan. ⁶²	Okazawa R...Takeuchi M	36346554	2022
30	Prompt and Sustained Suppression of Intraocular Inflammation with Adalimumab in Pediatric Patients with Non-Infectious Uveitis Resistant to Traditional Managements: A 6-Month Follow-Up Research. ⁶²	Sonmez HK...Gulmez Sevim D	36322874	2022
31	A review of patient-reported outcome measures used in uveitis. ⁶²	Senthil MP...Constable PA	36395825	2022
32	RISK OF INTRAOCULAR INFLAMMATION AFTER INJECTION OF ANTIVASCULAR ENDOTHELIAL GROWTH FACTOR AGENTS: A Meta-analysis. ⁶²	Patil NS...Muni RH	36269802	2022
33	Severe Vaso-Occlusive and Ocular Decompression Retinopathy Revealing a Sickle Cell Trait in a Patient with Herpetic Uveitis. ⁶²	Toutain J...Titah C	36442016	2022
34	DELAYED-ONSET STREPTOCOCCUS INTERMEDIUS ENDOPHTHALMITIS FOLLOWING ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR INTRAVITREAL INJECTION. ⁶²	Mercer GD...Chen JC	33165298	2022
35	Clinical and Morphologic Characteristics of Perivenular Fernlike Leakage on Ultrawide-field Fluorescein Angiography. ⁶²	Ramtohul P...Sarraf D	35545196	2022
36	Inflammation after Voretigene Neparvovec Administration in Patients with RPE65-Related Retinal Dystrophy. ⁶²	Kessel L...Klemp K	35760216	2022
37	Endocyclophotocoagulation by pars plana approach in the management of refractory glaucoma with prior phacoemulsification and Ahmed gonioimplantation in a dog. ⁶²	Kaminsky M...Konrade K	36321590	2022
38	Atypical anterior retinoblastoma: diagnosis by aqueous humor cell-free DNA analysis. ⁶²	Kletke SN...Gallie BL	36326029	2022
39	A multicenter study of ocular inflammation after COVID-19 vaccination. ⁶²	Yasaka Y...JOIS Uveitis Survey Working Group	36417027	2022
40	Bilateral posterior scleritis due to giant cell arteritis. ⁶²	Karimi A...Negretti G	36428030	2022
41	Acquired acoria and iris pearls in leprosy: Case report. ⁶²	Morais LNA...Almeida EF	34142579	2022
42	Randomized trial of bilateral gene therapy injection for m.11778G > A MT-ND4 Leber optic neuropathy. ⁶²	Newman NJ...LHON REFLECT Study Group	36350566	2022
43	Onset of spondyloarthritis in a patient treated with adalimumab for relapsing anterior uveitis - efficacy of secukinumab on the joint domain and on ocular inflammatory relapses: A case report. ⁶²	Raimondo V	36451402	2022
44	[Colchicine and non-severe ocular inflammation excluding Behcet's disease: 16 cases and literature review]. ⁶²	Rogier T...Devilliers H	36068122	2022
45	Ophthalmic manifestations of ROSAH Syndrome, an inherited NF-κB mediated autoinflammatory disease with retinal dystrophy. ⁶²	Huryn LA...Kodati S	36332842	2022
46	COVID-19 Vaccine-Associated Ocular Adverse Effects: An Overview. ⁶²	Ichhpujani P...Kumar S	36366386	2022
47	Inflammatory ocular events after inactivated COVID-19 vaccination. ⁶²	Fei P...Zhao P	36369840	2022
48	Hyphema and secondary glaucoma as a presenting complaint in a dog with chronic lymphocytic leukemia. ⁶²	Dehghanpir SD...Carter RT	36415701	2022
49	Long-term outcomes of small-incision cataract surgery in patients with uveitis. ⁶²	Bhargava R...Mehta B	36308129	2022
50	Therapeutic Vitrectomy in the Management of Uveitis: Opportunities and Challenges. ⁶²	Vithalani NM...Basu S	35608546	2022

Sources

Genes for Anterior Uveitis

Genes related to Anterior Uveitis (0 elite genes):

(show all 27)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	TLR4	Toll Like Receptor 4	Protein Coding	17.2	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17389503
2	IL6	Interleukin 6	Protein Coding	14.35	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	TLR2	Toll Like Receptor 2	Protein Coding	12.62	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
4	CFHR2	Complement Factor H Related 2	Protein Coding	7.63	DISEASES inferred ¹⁴ ¹⁴
5	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	7.6	DISEASES inferred ¹⁴ ¹⁴
6	TNF	Tumor Necrosis Factor	Protein Coding	7.22	DISEASES inferred ¹⁴
7	RBP3	Retinol Binding Protein 3	Protein Coding	7.01	DISEASES inferred ¹⁴
8	CRP	C-Reactive Protein	Protein Coding	6.96	DISEASES inferred ¹⁴
9	ERAP1	Endoplasmic Reticulum Aminopeptidase 1	Protein Coding	6.89	DISEASES inferred ¹⁴
10	HLA-B	Major Histocompatibility Complex, Class I, B	Protein Coding	6.82	DISEASES inferred ¹⁴
11	CD4	CD4 Molecule	Protein Coding	6.8	DISEASES inferred ¹⁴
12	ACE	Angiotensin I Converting Enzyme	Protein Coding	6.69	DISEASES inferred ¹⁴
13	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	6.69	DISEASES inferred ¹⁴ ¹⁴
14	MRAP	Melanocortin 2 Receptor Accessory Protein	Protein Coding	6.68	DISEASES inferred ¹⁴
15	IL17A	Interleukin 17A	Protein Coding	6.68	DISEASES inferred ¹⁴
16	IL23R	Interleukin 23 Receptor	Protein Coding	6.36	DISEASES inferred ¹⁴
17	IL10	Interleukin 10	Protein Coding	6.26	DISEASES inferred ¹⁴
18	CD8A	CD8a Molecule	Protein Coding	6.17	DISEASES inferred ¹⁴
19	SERPINA3	Serpin Family A Member 3	Protein Coding	6.14	DISEASES inferred ¹⁴ ¹⁴
20	IL1B	Interleukin 1 Beta	Protein Coding	6.11	DISEASES inferred ¹⁴
21	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	6.1	DISEASES inferred ¹⁴
22	IFNG	Interferon Gamma	Protein Coding	6.05	DISEASES inferred ¹⁴
23	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	6.04	DISEASES inferred ¹⁴
24	SAG	S-Antigen Visual Arrestin	Protein Coding	6.03	DISEASES inferred ¹⁴
25	IL2	Interleukin 2	Protein Coding	5.97	DISEASES inferred ¹⁴
26	ERAP2	Endoplasmic Reticulum Aminopeptidase 2	Protein Coding	5.94	DISEASES inferred ¹⁴
27	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	5.89	DISEASES inferred ¹⁴

Sources

Variations for Anterior Uveitis

Sources

Expression for Anterior Uveitis

Search GEO for disease gene expression data for Anterior Uveitis.

Sources

Pathways for Anterior Uveitis

Pathways related to Anterior Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.74	CCR6 CD4 CD8A CFHR2 CRP ERAP1
2	MIF Mediated Glucocorticoid Regulation ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ Overview of proinflammatory and profibrotic mediators ⁷⁴ PEDF Induced Signaling ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.64	TNF TLR4 IL6 IL23R IL1B IL17A
3	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.44	TNF TLR4 TLR2 IL6 IL23R IL1B
4	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.35	TNF IL6 IL23R IL1B IL17A IL10
5	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.32	TNF IL6 IL23R IL1B IL17A IL10
6	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.84	TNF TLR4 TLR2 IL6 IL1B
7	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.72	TNF TLR4 TLR2 IL6 IL1B
8	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.67	TNF IL6 IL23R IL1B IL17A IL10
9	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.62	CD4 IL10 IL17A IL1B IL23R IL6
10	NF-kappaB Signaling ³	12.61	TNF TLR2 IL1B IL17A IL10 CD8A
11	Toll-Like receptor Signaling Pathways ⁶⁵ Show member pathways Inflammasome Activation Pathways ⁶⁵ Nanomaterial-induced inflammasome activation ⁷⁴ NOD-like Receptor Signaling Pathways ⁶⁵ TLR4 signaling and tolerance ⁷⁴ Toll-Like Receptors Pathway ⁶⁴	12.55	TNF TLR4 TLR2 IL6 IL1B
12	Bacterial infections in CF airways ²² Show member pathways Altered glycosylation of MUC1 in tumor microenvironment ⁷⁴ IL-1 beta-dependent CFTR expression ²² IL1-mediated signaling events ⁶¹ Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²² NTHi-Induced Signaling ⁶⁴ Signal transduction through IL1R ⁷⁴	12.46	TNF TLR4 TLR2 IL6 IL1B
13	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.31	TNF TLR4 IL6 IL1B
14	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ⁶⁷ IL-17 signaling pathway ⁷⁴ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.29	TNF TLR2 IL6 IL17A
15	Colorectal Cancer Metastasis ⁶⁴	12.21	TNF TLR4 TLR2 IL6
16	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12.19	TNF IL6 IL1B IL10
17	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.17	TNF IL23R IL17A IL10 CD8A CD4
18	Neuroinflammation and glutamatergic signaling ⁷⁴	12.12	TNF IL6 IL1B IL10
19	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	12.06	TNF IL6 IL10 CD8A CD4
20	Spinal cord injury ⁷⁴	12.03	IL1B IL6 TLR4 TNF
21	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.99	TNF IL6 IL23R IL1B IL17A IL10
22	Allograft rejection ⁷⁴	11.94	TNF IL1B IL17A IL10 HLA-B
23	Cytokine production by Th17 cells in CF (Mouse model) ²² Show member pathways Cytokine production by Th17 cells in CF ²²	11.92	TLR4 IL6 IL23R IL17A
24	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.83	CD4 CD8A CRP IL6
25	Burn wound healing ⁷⁴	11.81	TNF TLR4 IL6 IL1B
26	Acute viral myocarditis ⁷⁴	11.81	TLR4 IL6 IL10 CD4
27	Th17 cell differentiation pathway ⁷⁴	11.76	IL6 IL23R IL1B IL17A CD4
28	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.75	TNF IL6 IL1B IL10 CD8A CD4
29	miRNAs involvement in the immune response in sepsis ⁷⁴	11.72	TNF TLR4 IL6 IL10
30	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.7	TNF TLR4 IL6 IL10 ICOSLG CRP
31	IL 10 signaling pathway ⁶⁷	11.69	TNF TLR4 IL6 IL1B IL10
32	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.68	TNF IL6 IL1B
33	Lung fibrosis ⁷⁴	11.68	TNF IL6 IL1B
34	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.66	TLR4 TLR2 IL6 IL23R IL1B IL17A
35	NF-kB (NFkB) Pathway ⁶⁷	11.62	TNF TLR4 CD4
36	MSP-RON Signaling ⁶⁴	11.59	TNF TLR4 TLR2 IL1B
37	Non-genomic actions of 1,25 dihydroxyvitamin D3 ⁷⁴	11.58	TNF TLR4 IL6
38	Interleukin-10 signaling ⁶⁶	11.58	IL10 IL1B IL6 TNF
39	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.57	TNF TLR4 TLR2 IL6 IL23R IL10
40	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.52	TNF IL6 IL1B
41	Fibrin complement receptor 3 signaling pathway ⁷⁴	11.49	TNF TLR4 IL6
42	Innate Lymphoid Cells Differentiation ⁶⁵	11.46	TNF IL23R IL1B IL17A IL10 CD8A
43	IL-10 Pathway ⁶⁴	11.4	IL10 IL1B IL6 TLR4 TNF
44	Development and heterogeneity of the ILC family ⁷⁴	11.39	TNF IL6 IL1B IL17A
45	Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway ⁷⁴	11.33	TNF IL6 IL1B
46	Prostaglandin signaling ⁷⁴	11.32	TNF IL6 IL1B IL17A
47	Immune infiltration in pancreatic cancer ⁷⁴	11.29	TNF IL6 IL17A IL10
48	Cytokines and inflammatory response ⁷⁴	11.29	TNF IL6 IL1B IL10 CD4
49	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.28	TNF TLR4 TLR2 IL6 IL23R IL1B
50	LDL- influence on CD14 and TLR4 ⁷⁴	11.16	TLR4 IL6 IL1B IL10

Sources

GO Terms for Anterior Uveitis

Cellular components related to Anterior Uveitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	10.3	TNF SERPINA3 RBP3 IL6 IL1B IL17A
2	extracellular region	GO:0005576	10.23	ACE CD8A CFHR2 CRP ERAP1 IL10
3	plasma membrane	GO:0005887	10.03	ACE CCR6 CD4 CD8A HLA-B TLR2
4	plasma membrane	GO:0005886	10.03	ACE CCR6 CD4 CD8A HLA-B TLR2
5	external side of plasma membrane	GO:0009897	9.58	TNF TLR4 IL23R IL17A ICOSLG CD8A

Biological processes related to Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 44)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.61	CCR6 CD4 ERAP1 ICOSLG IL10 IL1B
2	adaptive immune response	GO:0002250	10.45	CD4 CD8A ERAP1 HLA-B ICOSLG IL17A
3	positive regulation of DNA-binding transcription factor activity	GO:0051091	10.27	TNF IL6 IL1B IL10
4	positive regulation of tumor necrosis factor production	GO:0032760	10.26	TLR4 TLR2 IL6 IL17A
5	cellular response to lipopolysaccharide	GO:0071222	10.26	IL10 IL1B IL6 TLR4 TNF
6	positive regulation of NF-kappaB transcription factor activity	GO:0051092	10.24	TNF TLR4 TLR2 IL6 IL1B
7	positive regulation of type II interferon production	GO:0032729	10.22	TNF TLR4 IL23R IL1B
8	positive regulation of inflammatory response	GO:0050729	10.22	TNF TLR4 TLR2 IL1B ACE
9	positive regulation of NIK/NF-kappaB signaling	GO:1901224	10.2	TNF TLR4 TLR2 IL1B
10	positive regulation of interleukin-1 beta production	GO:0032731	10.19	TNF TLR4 IL6 IL17A
11	defense response to Gram-negative bacterium	GO:0050829	10.18	TLR4 IL6 IL23R IL17A CD4
12	defense response to Gram-positive bacterium	GO:0050830	10.18	CRP IL17A IL1B IL6 TLR2 TNF
13	positive regulation of nitric oxide biosynthetic process	GO:0045429	10.17	TNF TLR4 IL1B
14	positive regulation of interleukin-10 production	GO:0032733	10.16	TLR4 TLR2 IL6
15	acute-phase response	GO:0006953	10.15	SERPINA3 IL6 CRP
16	positive regulation of interleukin-12 production	GO:0032735	10.15	IL17A IL23R TLR2 TLR4
17	positive regulation of receptor signaling pathway via JAK-STAT	GO:0046427	10.14	IL10 IL6 TNF
18	liver regeneration	GO:0097421	10.13	IL10 IL6 TNF
19	positive regulation of interleukin-8 production	GO:0032757	10.13	TNF TLR4 TLR2 IL6 IL1B
20	negative regulation of neurogenesis	GO:0050768	10.12	TNF IL6 IL1B
21	positive regulation of osteoclast differentiation	GO:0045672	10.11	TNF IL23R IL17A
22	lipopolysaccharide-mediated signaling pathway	GO:0031663	10.11	IL1B TLR2 TLR4 TNF
23	inflammatory response	GO:0006954	10.11	CRP IL17A IL1B IL23R IL6 SERPINA3
24	positive regulation of interleukin-6 production	GO:0032755	10.1	IL17A IL1B IL6 TLR2 TLR4 TNF
25	positive regulation of glial cell proliferation	GO:0060252	10.08	TNF IL6 IL1B
26	positive regulation of cytokine production involved in inflammatory response	GO:1900017	10.06	IL17A IL6 TLR4 TNF
27	positive regulation of heterotypic cell-cell adhesion	GO:0034116	10.05	IL10 IL1B TNF
28	positive regulation of neuroinflammatory response	GO:0150078	10.03	TNF IL6 IL1B
29	positive regulation of chemokine production	GO:0032722	10.02	TNF TLR4 TLR2 IL6 IL1B
30	negative regulation of lipid storage	GO:0010888	10.01	TNF IL6 CRP
31	negative regulation of cytokine production involved in immune response	GO:0002719	9.99	TNF IL10
32	intestinal epithelial structure maintenance	GO:0060729	9.98	TLR4 IL17A
33	positive regulation of fever generation	GO:0031622	9.98	TNF IL1B
34	antigen processing and presentation of peptide antigen via MHC class I	GO:0002474	9.97	HLA-B ERAP1 ACE
35	vascular endothelial growth factor production	GO:0010573	9.97	TNF IL6 IL1B
36	sequestering of triglyceride	GO:0030730	9.96	TNF IL1B
37	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.95	TNF IL1B
38	positive regulation of matrix metallopeptidase secretion	GO:1904466	9.94	TLR4 TLR2
39	chronic inflammatory response to antigenic stimulus	GO:0002439	9.93	IL10 TNF
40	negative regulation of gap junction assembly	GO:1903597	9.93	ACE IL1B
41	positive regulation of cellular response to macrophage colony-stimulating factor stimulus	GO:1903974	9.92	TLR2 TLR4
42	immune system process	GO:0002376	9.91	TLR4 TLR2 IL23R IL17A ICOSLG HLA-B
43	response to lipopolysaccharide	GO:0032496	9.7	TNF TLR4 TLR2 IL23R IL1B IL10
44	immune response	GO:0006955	9.6	TNF TLR4 TLR2 IL6 IL1B IL17A