MCID: ANT034
MIFTS: 54

Anterior Uveitis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Anterior Uveitis

MalaCards integrated aliases for Anterior Uveitis:

Name: Anterior Uveitis 54 17 74
Iridocyclitis 54 74
Acute Anterior Uveitis 74

Classifications:



External Ids:

Summaries for Anterior Uveitis

MalaCards based summary : Anterior Uveitis, also known as iridocyclitis, is related to spondylitis and spondyloarthropathy 1. An important gene associated with Anterior Uveitis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Adalimumab and Ganciclovir have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and t cells, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Anterior Uveitis

Diseases in the Uveitis family:

Autoimmune Uveitis Posterior Uveitis
Intermediate Uveitis Infectious Anterior Uveitis
Anterior Uveitis Infectious Posterior Uveitis

Diseases related to Anterior Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 404)
# Related Disease Score Top Affiliating Genes
1 spondylitis 31.0 HLA-B IL6 TNF
2 spondyloarthropathy 1 31.0 HLA-B TLR4 TNF
3 arthritis 30.5 IL6 PTPN22 TNF
4 choroiditis 30.3 CFH TNF
5 pars planitis 30.2 HLA-A HLA-B
6 localized scleroderma 30.1 IL6 TNF
7 joint disorders 30.1 IL6 TNF
8 stromal keratitis 30.1 IL6 TNF
9 rubella 30.1 HLA-A HLA-B TNF
10 tuberculous meningitis 30.0 TLR2 TNF
11 multifocal choroiditis 30.0 CFH TNF
12 colitis 29.9 IL6 TLR4 TNF
13 vasculitis 29.9 CFI HLA-B TNF
14 cysticercosis 29.9 IL6 TLR4
15 cytomegalovirus retinitis 29.9 HLA-A HLA-B TNF
16 ulcerative colitis 29.8 IL6 TLR4 TNF
17 intermediate uveitis 29.8 HLA-B IL6 TNF
18 mycoplasma pneumoniae pneumonia 29.8 IL6 TLR2 TNF
19 toxoplasmosis 29.8 IL6 TLR2 TLR4 TNF
20 mycobacterium abscessus 29.7 TLR2 TNF
21 acquired immunodeficiency syndrome 29.7 HLA-B IL6 TNF
22 glaucomatocyclitic crisis 29.7 HLA-A HLA-B TNF
23 spondyloarthropathy 29.7 HLA-A HLA-B IL6 TNF
24 panuveitis 29.6 HLA-A HLA-B TNF
25 peritonitis 29.6 IL6 TLR2 TNF
26 pneumonia 29.6 IL6 TLR2 TLR4 TNF
27 leishmaniasis 29.6 TLR2 TLR4 TNF
28 inflammatory bowel disease 29.6 IL6 TLR2 TLR4 TNF
29 leptospirosis 29.6 IL6 TLR2 TNF
30 bacterial meningitis 29.6 IL6 TLR2 TNF
31 meningitis 29.6 IL6 TLR2 TNF
32 trypanosomiasis 29.5 IL6 TLR2 TNF
33 temporal arteritis 29.5 IL6 PTPN22 TNF
34 chlamydia 29.5 IL6 TLR2 TLR4 TNF
35 vogt-koyanagi-harada disease 29.5 HLA-A HLA-B PTPN22
36 common variable immunodeficiency 29.5 IL6 TLR2 TNF
37 cytomegalovirus infection 29.3 HLA-A HLA-B IL6 TNF
38 graft-versus-host disease 29.3 HLA-A HLA-B IL6 TNF
39 q fever 29.3 IL6 TLR2 TLR4 TNF
40 psoriatic arthritis 29.2 HLA-B IL6 PTPN22 TNF
41 diabetes mellitus 29.0 HLA-A HLA-B IL6 PTPN22 TNF
42 rheumatoid arthritis 29.0 HLA-B IL6 PTPN22 TLR2 TLR4 TNF
43 systemic lupus erythematosus 28.7 IL6 PTPN22 TLR2 TLR4 TNF
44 infectious anterior uveitis 12.4
45 idiopathic anterior uveitis 12.4
46 fuchs' heterochromic uveitis 12.3
47 lens-induced iridocyclitis 12.2
48 gonococcal iridocyclitis 12.1
49 phacoanaphylactic uveitis 11.6
50 uveitis 11.2

Graphical network of the top 20 diseases related to Anterior Uveitis:



Diseases related to Anterior Uveitis

Symptoms & Phenotypes for Anterior Uveitis

MGI Mouse Phenotypes related to Anterior Uveitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 CFH IL6 PTPN22 TLR2 TLR4 TNF
2 hematopoietic system MP:0005397 9.8 CFH CFI IL6 PTPN22 TLR2 TLR4
3 digestive/alimentary MP:0005381 9.72 IL6 PTPN22 TLR2 TLR4 TNF
4 liver/biliary system MP:0005370 9.55 IL6 PTPN22 TLR2 TLR4 TNF
5 renal/urinary system MP:0005367 9.43 CFH CFI IL6 PTPN22 TLR2 TLR4
6 respiratory system MP:0005388 9.02 IL6 PTPN22 TLR2 TLR4 TNF

Drugs & Therapeutics for Anterior Uveitis

Drugs for Anterior Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 119)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4,Phase 3 331731-18-1 16219006
2
Ganciclovir Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 82410-32-0 3454
3
Acyclovir Approved Phase 4,Phase 3 59277-89-3 2022
4
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
5
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
7
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
8
leucovorin Approved Phase 4,Phase 1,Not Applicable 58-05-9 6006 143
9
Methotrexate Approved Phase 4,Not Applicable 1959-05-2, 59-05-2 126941
10
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
11
Dinoprost Approved, Investigational Phase 4 551-11-1 5283078
12
Dinoprost tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
13
Difluprednate Approved Phase 4,Phase 3,Phase 2 23674-86-4 443936
14
Certolizumab pegol Approved Phase 4,Phase 3 428863-50-7
15
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Not Applicable 59-30-3 6037
16
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2920-86-7
17 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Antirheumatic Agents Phase 4,Phase 3,Not Applicable
23 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
24 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25 Ganciclovir triphosphate Phase 4,Phase 2,Phase 3,Not Applicable
26 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Methylprednisolone Acetate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Prednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Folic Acid Antagonists Phase 4,Phase 1,Not Applicable
31 Dermatologic Agents Phase 4,Phase 3,Not Applicable
32 Antimetabolites, Antineoplastic Phase 4,Not Applicable
33 Folate Phase 4,Phase 1,Not Applicable
34 Vitamin B9 Phase 4,Phase 1,Not Applicable
35 Antimetabolites Phase 4,Not Applicable
36 Vitamin B Complex Phase 4,Phase 1,Not Applicable
37 beta-endorphin Phase 4,Not Applicable
38 Melanocyte-Stimulating Hormones Phase 4,Not Applicable
39 Adrenocorticotropic Hormone Phase 4,Not Applicable
40 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Antihypertensive Agents Phase 4
42 Oxytocics Phase 4
43 Benzalkonium Compounds Phase 4,Phase 3
44 Lubricant Eye Drops Phase 4
45 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Anti-Infective Agents, Local Phase 4,Phase 3
47 valacyclovir Phase 4
48
Ranibizumab Approved Phase 2, Phase 3 347396-82-1 459903
49
Etanercept Approved, Investigational Phase 3,Not Applicable 185243-69-0
50
Fluprednisolone Approved Phase 3,Phase 2 53-34-9

Interventional clinical trials:

(show top 50) (show all 68)
# Name Status NCT ID Phase Drugs
1 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
2 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
3 A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment Completed NCT02897115 Phase 4
4 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4 2% guttae ganciclovir
5 A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU Active, not recruiting NCT03020992 Phase 4 Certolizumab Pegol
6 A Randomized Trial of Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis Not yet recruiting NCT03626376 Phase 4 oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily;oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily + topical corticosteroid eye drops
7 Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis Terminated NCT02769702 Phase 4 Acthar
8 Methotrexate in the Treatment of Axial Spondyloarthritis Withdrawn NCT00298012 Phase 4 Methotrexate
9 Herpetic Eye Disease Study (HEDS) I Unknown status NCT00000138 Phase 3 Prednisolone Phosphate;Acyclovir
10 Double-dose Ranibizumab for Polypoidal Choroidal Vasculopathy Unknown status NCT02769169 Phase 2, Phase 3 Lucentis® (Raibizumab) double-dose;Lucentis® (Raibizumab) regular-dose
11 Safety and Efficacy of Difluprednate 0.05% for the Treatment of Anterior Uveitis Completed NCT01201798 Phase 3 Difluprednate 0.05% ophthalmic emulsion;Prednisolone acetate 1.0% ophthalmic suspension
12 A Multi-center Study to Assess the Efficacy and Safety of LX211 in Active Non-infectious Anterior Uveitis Completed NCT00404885 Phase 3 Placebo;LX211;LX211;LX211
13 Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Non-Infectious Anterior Uveitis Completed NCT02517619 Phase 3 Dexamethasone Phosphate Ophthalmic Solution;Prednisolone Acetate Ophthalmic (1%)
14 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00406887 Phase 3 Difluprednate Ophthalmic Emulsion
15 Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis Completed NCT01505088 Phase 3 40 mg/mL Dexamethasone phosphate ophthalmic solution;Prednisolone Acetate (1%) Eyedrops;100 mM sodium citrate buffer solution;Placebo Eyedrops
16 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Severe Uveitis Completed NCT00407056 Phase 3 Difluprednate Ophthalmic Emulsion
17 Study of Difluprednate in the Treatment of Uveitis Completed NCT00501579 Phase 3 Difluprednate;Prednisolone Acetate
18 Herpetic Eye Disease Study (HEDS) II Completed NCT00000139 Phase 3 Acyclovir
19 Suprachoroidal Injection of CLS-TA in Subjects Non-infectious Uveitis Completed NCT03097315 Phase 3
20 Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis Completed NCT02595398 Phase 3 4mg CLS-TA Suprachoriodal Injection;Sham Procedure
21 CLARITY Extension Study Completed NCT00641537 Phase 3 Cladribine;Placebo;Cladribine;Cladribine;Placebo
22 A Study of Ixekizumab (LY2439821) in bDMARD-Naive Participants With Radiographic Axial Spondyloarthritis Completed NCT02696785 Phase 3 Ixekizumab;Placebo;Adalimumab
23 SOLACE Trial - A Phase 3 Trial in Subjects With Non-infectious Anterior-uveitis. Recruiting NCT03131154 Phase 3 ADX-102 Ophthalmic Solution (0.5%);Vehicle of ADX-102 Ophthalmic Solution
24 Treatment Tapering in JIA With Inactive Disease Recruiting NCT02840175 Phase 3 etanercept;adalimumab;Abatacept;Tocilizumab
25 A Long Term Extension Study of Ixekizumab (LY2439821) in Participants With Axial Spondyloarthritis Recruiting NCT03129100 Phase 3 Ixekizumab;Placebo
26 Multicenter Study Evaluating Certolizumab Pegol Compared to Placebo in Subjects With axSpA Without X-ray Evidence of AS Active, not recruiting NCT02552212 Phase 3
27 A Study of Ixekizumab (LY2439821) in Participants With Nonradiographic Axial Spondyloarthritis Active, not recruiting NCT02757352 Phase 3 Ixekizumab;Placebo
28 A Study of Ixekizumab (LY2439821) in TNF Inhibitor Experienced Participants With Radiographic Axial Spondyloarthritis Active, not recruiting NCT02696798 Phase 3 Ixekizumab;Placebo
29 Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis: Treatment Outcomes Not yet recruiting NCT03586284 Phase 2, Phase 3 Valganciclovir Hydrochloride;Ganciclovir Sodium;Placebo Oral Tablet;Topical placebo
30 Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis Not yet recruiting NCT03576898 Phase 2, Phase 3 Topical ganciclovir versus oral valganciclovir versus placebo
31 Preventing Extension of Oligoarticular Juvenile Idiopathic Arthritis JIA (Limit-JIA) Not yet recruiting NCT03841357 Phase 3 Abatacept Injection
32 A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Anterior Uveitis Terminated NCT00333996 Phase 2, Phase 3 Dexamethasone
33 Proof of Concept Study to Evaluate Safety and Efficacy of LME636 in the Treatment of Acute Anterior Uveitis Completed NCT02482129 Phase 2 LME636 60 mg/mL ophthalmic solution;Dexamethasone 0.1% ophthalmic solution;LME636 Vehicle
34 A Safety and Efficacy Study of NS2 in Patients With Anterior Uveitis Completed NCT02406209 Phase 2 NS2;Prednisolone acetate ophthalmic suspension (1%)
35 Safety and Efficacy Study of DSP-Visulex for the Treatment of Anterior Uveitis Completed NCT02309385 Phase 1, Phase 2 8% Dexamethasone Sodium Phosphate - Visulex;15% Dexamethasone Sodium Phosphate - Visulex;Prednisolone Acetate (1%) Eye Drops
36 Exploratory Study on Topical ESBA105 in Acute Anterior Uveitis Completed NCT00823173 Phase 2
37 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00405496 Phase 2 Difluprednate Ophthalmic Emulsion
38 Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis Completed NCT00130637 Phase 2 Daclizumab
39 Safety and Efficacy Study of Iontophoresis and Dexamethasone Phosphate to Treat Anterior Uveitis Completed NCT00694135 Phase 2 EGP-437 1.6 mA-min at 0.4 with EyeGate® II System;EGP-437 4.8 mA-min at 1.2 mA with EyeGate® II System;EGP-437 10.0 mA-min at 2.5 mA with EyeGate® II System;EGP-437 14.0 mA-min at 3.5 mA with EyeGate® II System
40 Topical Interferon Gamma for Macular Edema Secondary to Uveitis Completed NCT01376362 Phase 1, Phase 2 Interferon Gamma-1b
41 Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis Completed NCT02255032 Phase 2 4 mg CLS-TA;0.8 mg CLS-TA
42 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2 AIN457;AIN 457;AIN457
43 A Phase I/IIa Study for the Treatment of Uveitis With Iontophoresis Withdrawn NCT00499551 Phase 1, Phase 2
44 Subconjunctival Sirolimus for the Treatment of Autoimmune Active Anterior Uveiti Completed NCT00876434 Phase 1 Sirolimus
45 Study to Evaluate GSK3052230 in Combination With Paclitaxel and Carboplatin, or Docetaxel or as Single Agent in Subjects With Solid Malignancies and Deregulated Fibroblast Growth Factor (FGF) Pathway Signaling Completed NCT01868022 Phase 1 GSK3052230;paclitaxel;carboplatin;docetaxel;pemetrexed;cisplatin
46 Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Withdrawn NCT02042027 Phase 1 Gamunex-C
47 Acute Anterior Uveitis: Psychic Burden and Pain Unknown status NCT01156285
48 Clinical Outcomes of Topical Ganciclovir Treatment in Cytomegalovirus Anterior Uveitis Unknown status NCT01486693
49 Variations in Retinal Nerve Fiber Layer Thickness During Uncomplicated Anterior and Intermediate Uveitis Unknown status NCT02879084
50 Etanercept: Single Blind Control Study in Ocular Manifestations of Behcet's Disease Unknown status NCT00931957 Not Applicable Etanercept, Methotrexate, Prednisolone

Search NIH Clinical Center for Anterior Uveitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Anterior Uveitis

Anatomical Context for Anterior Uveitis

MalaCards organs/tissues related to Anterior Uveitis:

42
Eye, Endothelial, T Cells, Thyroid, Prostate, Testes, Neutrophil

Publications for Anterior Uveitis

Articles related to Anterior Uveitis:

(show top 50) (show all 914)
# Title Authors Year
1
Aqueous Humor Analysis Identifies Higher Branched Chain Amino Acid Metabolism as a Marker for Human Leukocyte Antigen-B27 Acute Anterior Uveitis and Disease Activity. ( 30312576 )
2019
2
Aqueous tap and rapid diagnosis of cytomegalovirus anterior uveitis: the Reggio Emilia experience. ( 30392022 )
2019
3
PD-1 Polymorphisms Are Associated with Susceptibility of Acute Anterior Uveitis in Chinese Population. ( 30540488 )
2019
4
Acute anterior uveitis in spondyloarthritis: a monocentric study of 301 patients. ( 30620268 )
2019
5
BISPHOSPHONATE-INDUCED BILATERAL ANTERIOR UVEITIS AND CHOROIDAL EFFUSIONS WITH SECONDARY ANGLE CLOSURE. ( 30640817 )
2019
6
Chronic Anterior Uveitis in a Patient with CREST Syndrome. ( 30691950 )
2019
7
Inhibitory role of transforming growth factor β2 in experimental autoimmune anterior uveitis. ( 30719689 )
2019
8
Efficacy of anti-tumour necrosis factor-α monoclonal antibodies in patients with non-infectious anterior uveitis. ( 30719968 )
2019
9
Emerging Viral Infections Causing Anterior Uveitis. ( 30794475 )
2019
10
Risk factors associated with persistent anterior uveitis after cataract surgery. ( 30794788 )
2019
11
Preventive effects of tyrosol, a natural phenolic compound, on anterior uveitis induced by anterior chamber paracentesis in healthy beagle dogs. ( 30799325 )
2019
12
Evaluation of choroidal parameters in eyes at the first onset of acute anterior uveitis. ( 30819128 )
2019
13
Novel gene targets for miRNA146a and miRNA155 in anterior uveitis. ( 30297336 )
2019
14
Inflammatory bowel disease and acute anterior uveitis, but not psoriasis are associated with disease duration in Axial SpA: results from the (Be)Giant and ASPECT cohort. ( 29740978 )
2018
15
Diagnosis of Cytomegalovirus Anterior Uveitis in Two European Referral Centers. ( 29377783 )
2018
16
The pathogenic role of dendritic cells in non-infectious anterior uveitis. ( 29763582 )
2018
17
Increased Circulating Proinflammatory T Lymphocytes in Children with Different Forms of Anterior Uveitis: Results from a Pilot Study. ( 29771573 )
2018
18
Recurrent anterior uveitis and subsequent incidence of ankylosing spondylitis: a nationwide cohort study from 2002 to 2013. ( 29415753 )
2018
19
A study of the key genes and inflammatory signaling pathways involved in HLA-B27-associated acute anterior uveitis families. ( 29620146 )
2018
20
Clinical Characteristics of Herpes Simplex Virus Associated Anterior Uveitis. ( 29345511 )
2018
21
Elevated interleukin 37 expression associated with disease activity in HLA-B27 associated anterior uveitis and idiopathic anterior uveitis. ( 29424310 )
2018
22
Childhood Arthritis and Rheumatology Research Alliance consensus treatment plans for juvenile idiopathic arthritis-associated and idiopathic chronic anterior uveitis. ( 29806733 )
2018
23
Association of IL33 and IL1RAP polymorphisms with acute anterior uveitis. ( 29424312 )
2018
24
Clinical Features of CMV-Associated Anterior Uveitis. ( 29172842 )
2018
25
Immunopathology of Virus-Induced Anterior Uveitis. ( 29543540 )
2018
26
Hypertensive acute granulomatous anterior uveitis as a side effect of topical brimonidine. ( 29910082 )
2018
27
Tonic Pupil in Cytomegalovirus Anterior Uveitis in an Immunocompetent Adult Male - A Case Report. ( 29028408 )
2018
28
Multiplex Cytokine Analysis of Aqueous Humor in Juvenile Idiopathic Arthritis-Associated Anterior Uveitis With or Without Secondary Glaucoma. ( 29675026 )
2018
29
Prevalence of axial spondyloarthritis in patients with acute anterior uveitis: a cross-sectional study utilising MRI. ( 29531779 )
2018
30
PCR Multiplex for CMV Detection in Patients with Anterior Uveitis. ( 29474137 )
2018
31
Gut Microbiota Composition and Fecal Metabolic Phenotype in Patients With Acute Anterior Uveitis. ( 29625474 )
2018
32
Immunohistochemical characterization of feline lymphoplasmacytic anterior uveitis. ( 29517855 )
2018
33
Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis. ( 29511745 )
2018
34
Spondyloarthritis, Acute Anterior Uveitis, and Fungi: Updating the Catterall-King Hypothesis. ( 29675414 )
2018
35
Clinical features of patients with diabetic anterior uveitis. ( 29563110 )
2018
36
Syphilis-Related Eye Disease Presenting as Bilateral Papilledema, Retinal Nerve Fiber Layer Hemorrhage, and Anterior Uveitis in a Penicillin-Allergic Patient. ( 29670780 )
2018
37
Raised intracranial pressure with bilateral anterior uveitis. ( 29891509 )
2018
38
Chronic Anterior Uveitis in Children: Psychosocial Challenges for Patients and Their Families. ( 29601821 )
2018
39
Differential Diagnosis of Viral-Induced Anterior Uveitis. ( 29869892 )
2018
40
Anterior uveitis. ( 29290458 )
2018
41
Virus-Induced Anterior Uveitis (VIAU) in Immunocompromised Patients. ( 29969370 )
2018
42
The microbiome and HLA-B27-associated acute anterior uveitis. ( 30301938 )
2018
43
Herpetic Anterior Uveitis - Analysis of Presumed and PCR Proven Cases. ( 30311824 )
2018
44
Discovery of tear biomarkers in children with chronic non-infectious anterior uveitis: a pilot study. ( 30327966 )
2018
45
Demystifying viral anterior uveitis: a review. ( 30345620 )
2018
46
Viral disease of the year: Anterior uveitis. ( 30353994 )
2018
47
Novel Dexamethasone Sodium Phosphate Treatment (DSP-Visulex) for Noninfectious Anterior Uveitis: A Randomized Phase I/II Clinical Trial. ( 30354530 )
2018
48
Reduced Occurrence Rate of Acute Anterior Uveitis in Ankylosing Spondylitis Treated with Golimumab - The GO-EASY Study. ( 30385705 )
2018
49
The Management of Acute Anterior Uveitis Complicating Spondyloarthritis: Present and Future. ( 30406148 )
2018
50
Timing of infliximab and adalimumab initiation despite methotrexate in children with chronic non-infectious anterior uveitis. ( 30487588 )
2018

Variations for Anterior Uveitis

Expression for Anterior Uveitis

Search GEO for disease gene expression data for Anterior Uveitis.

Pathways for Anterior Uveitis

Pathways related to Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 CFH CFI HLA-A HLA-B IL6 PTPN22
2
Show member pathways
13.26 HLA-A HLA-B PTPN22 TLR2 TLR4
3
Show member pathways
13 IL6 TLR2 TLR4 TNF
4
Show member pathways
12.7 HLA-A HLA-B IL6 TNF
5
Show member pathways
12.7 HLA-A HLA-B IL6 TLR2 TLR4 TNF
6
Show member pathways
12.68 HLA-A HLA-B IL6 TLR2 TLR4 TNF
7
Show member pathways
12.53 IL6 TLR2 TLR4 TNF
8
Show member pathways
12.44 IL6 TLR2 TLR4 TNF
9
Show member pathways
12.33 HLA-A HLA-B TLR2 TLR4
10 12.22 HLA-A HLA-B IL6 TNF
11
Show member pathways
12.17 IL6 TLR2 TNF
12
Show member pathways
12.15 IL6 TLR4 TNF
13
Show member pathways
12.14 IL6 TLR2 TLR4 TNF
14 12.13 TLR2 TLR4 TNF
15
Show member pathways
12.11 HLA-A HLA-B IL6 TNF
16
Show member pathways
12.11 HLA-A HLA-B IL6 TLR2 TLR4 TNF
17 12.1 IL6 TLR2 TLR4 TNF
18
Show member pathways
12.09 TLR2 TLR4 TNF
19
Show member pathways
12.05 IL6 TLR2 TNF
20
Show member pathways
12.04 IL6 TLR2 TLR4 TNF
21 12.03 IL6 TLR2 TLR4 TNF
22 12.01 HLA-A HLA-B IL6
23 11.98 HLA-A HLA-B TLR2 TLR4
24
Show member pathways
11.89 IL6 TLR2 TLR4 TNF
25 11.87 IL6 TLR4 TNF
26
Show member pathways
11.86 IL6 TLR2 TLR4 TNF
27 11.65 IL6 TLR4 TNF
28 11.6 IL6 TLR2 TLR4 TNF
29 11.52 IL6 TLR2 TLR4 TNF
30 11.42 TLR2 TLR4 TNF
31 11.26 IL6 TLR4 TNF
32 11.24 IL6 TNF
33 11.17 IL6 TNF
34 11.16 IL6 TNF
35 11.12 IL6 TNF
36 11.04 HLA-A HLA-B
37 11 IL6 TLR2 TLR4 TNF
38 10.98 IL6 TNF
39 10.9 IL6 TNF
40 10.61 IL6 TLR2 TLR4 TNF

GO Terms for Anterior Uveitis

Cellular components related to Anterior Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.72 HLA-A HLA-B TLR2 TLR4 TNF
2 intrinsic component of plasma membrane GO:0031226 9.37 TLR2 TLR4
3 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-A HLA-B
4 MHC class I protein complex GO:0042612 9.16 HLA-A HLA-B
5 phagocytic vesicle membrane GO:0030670 9.13 HLA-A HLA-B TLR2
6 cell surface GO:0009986 9.02 HLA-A HLA-B TLR2 TLR4 TNF

Biological processes related to Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.93 CFH CFI TLR2 TLR4
2 inflammatory response GO:0006954 9.89 IL6 TLR2 TLR4 TNF
3 immune system process GO:0002376 9.88 HLA-A HLA-B PTPN22 TLR2 TLR4
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.85 PTPN22 TLR4 TNF
5 response to lipopolysaccharide GO:0032496 9.81 PTPN22 TLR2 TLR4
6 cellular response to lipopolysaccharide GO:0071222 9.81 IL6 TLR4 TNF
7 positive regulation of gene expression GO:0010628 9.8 IL6 PTPN22 TLR2 TLR4 TNF
8 defense response to Gram-positive bacterium GO:0050830 9.74 IL6 TLR2 TNF
9 immune response GO:0006955 9.73 HLA-A HLA-B IL6 TLR2 TLR4 TNF
10 positive regulation of inflammatory response GO:0050729 9.7 TLR2 TLR4 TNF
11 toll-like receptor signaling pathway GO:0002224 9.68 TLR2 TLR4
12 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.67 TLR2 TLR4
13 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.67 HLA-A HLA-B
14 negative regulation of interleukin-6 production GO:0032715 9.67 TLR4 TNF
15 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.67 IL6 TLR2 TLR4 TNF
16 positive regulation of interferon-beta production GO:0032728 9.66 TLR2 TLR4
17 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.66 HLA-A HLA-B
18 negative regulation of neurogenesis GO:0050768 9.65 IL6 TNF
19 positive regulation of interleukin-12 production GO:0032735 9.65 TLR2 TLR4
20 positive regulation of interleukin-10 production GO:0032733 9.65 TLR2 TLR4
21 positive regulation of T cell mediated cytotoxicity GO:0001916 9.64 HLA-A HLA-B
22 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.63 TLR2 TLR4 TNF
23 microglial cell activation GO:0001774 9.62 TLR2 TNF
24 positive regulation of glial cell proliferation GO:0060252 9.62 IL6 TNF
25 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.61 TLR2 TLR4
26 regulation of cytokine secretion GO:0050707 9.61 TLR2 TLR4
27 I-kappaB phosphorylation GO:0007252 9.6 TLR2 TLR4
28 cellular response to lipoteichoic acid GO:0071223 9.58 TLR2 TLR4
29 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.58 TLR4 TNF
30 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.56 HLA-A HLA-B
31 negative regulation of lipid storage GO:0010888 9.55 IL6 TNF
32 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.54 HLA-A HLA-B
33 positive regulation of neuroinflammatory response GO:0150078 9.51 IL6 TNF
34 positive regulation of interleukin-8 production GO:0032757 9.5 TLR2 TLR4 TNF
35 protection from natural killer cell mediated cytotoxicity GO:0042270 9.49 HLA-A HLA-B
36 positive regulation of interleukin-6 production GO:0032755 9.46 IL6 TLR2 TLR4 TNF
37 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.43 TLR2 TLR4
38 lipopolysaccharide-mediated signaling pathway GO:0031663 9.26 PTPN22 TLR2 TLR4 TNF
39 positive regulation of chemokine production GO:0032722 8.92 IL6 TLR2 TLR4 TNF

Molecular functions related to Anterior Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 9.16 TLR2 TLR4
2 peptide antigen binding GO:0042605 8.96 HLA-A HLA-B
3 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Anterior Uveitis

3 CDC
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10 dbSNP
11 DGIdb
17 EFO
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70 SNOMED-CT via HPO
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72 TGDB
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74 UMLS
75 UMLS via Orphanet
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