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MCID: ANT034
MIFTS: 54

Anterior Uveitis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Anterior Uveitis

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MalaCards integrated aliases for Anterior Uveitis:

Name: Anterior Uveitis 53 73
Iridocyclitis 53 73
Acute Anterior Uveitis 73

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases Neuronal diseases Immune diseases
See all MalaCards categories (disease lists)


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Summaries for Anterior Uveitis

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MalaCards based summary : Anterior Uveitis, also known as iridocyclitis, is related to uveitis and spondylitis. An important gene associated with Anterior Uveitis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Adalimumab and Ganciclovir have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Anterior Uveitis

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Diseases in the Uveitis family:

Autoimmune Uveitis Posterior Uveitis
Intermediate Uveitis Infectious Anterior Uveitis
Anterior Uveitis Infectious Posterior Uveitis

Diseases related to Anterior Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 395)
# Related Disease Score Top Affiliating Genes
1 uveitis 31.7 HLA-B IL2RA TNF
2 spondylitis 31.0 HLA-B IL6 TNF
3 spondyloarthropathy 1 31.0 HLA-B TLR4 TNF
4 arthritis 30.6 IL6 PTPN22 TNF
5 choroiditis 30.2 CFH TNF
6 pars planitis 30.1 HLA-A HLA-B
7 rubella 30.0 HLA-A HLA-B TNF
8 localized scleroderma 30.0 IL6 TNF
9 colitis 29.9 IL6 TLR4 TNF
10 toxoplasmosis 29.9 IL6 TLR2 TLR4 TNF
11 tuberculous meningitis 29.9 TLR2 TNF
12 cytomegalovirus retinitis 29.8 HLA-A HLA-B TNF
13 ulcerative colitis 29.8 IL6 TLR4 TNF
14 mycoplasma pneumoniae pneumonia 29.8 IL6 TLR2 TNF
15 multifocal choroiditis 29.8 CFH TNF
16 spondyloarthropathy 29.8 HLA-A HLA-B IL6 TNF
17 pneumonia 29.7 IL6 TLR2 TLR4 TNF
18 cysticercosis 29.7 IL6 TLR4
19 glaucomatocyclitic crisis 29.7 HLA-A HLA-B TNF
20 mycobacterium abscessus 29.6 TLR2 TNF
21 juvenile rheumatoid arthritis 29.6 IL2RA IL6 TNF
22 peritonitis 29.6 IL6 TLR2 TNF
23 panuveitis 29.6 HLA-A HLA-B TNF
24 chlamydia 29.6 IL6 TLR2 TLR4 TNF
25 leptospirosis 29.6 IL6 TLR2 TNF
26 bacterial meningitis 29.6 IL6 TLR2 TNF
27 meningitis 29.6 IL6 TLR2 TNF
28 trypanosomiasis 29.6 IL6 TLR2 TNF
29 temporal arteritis 29.5 IL6 PTPN22 TNF
30 stromal keratitis 29.4 IL2RA IL6 TNF
31 cytomegalovirus infection 29.4 HLA-A HLA-B IL6 TNF
32 graft-versus-host disease 29.4 HLA-A HLA-B IL6 TNF
33 leishmaniasis 29.4 IL6 TLR2 TLR4 TNF
34 q fever 29.4 IL6 TLR2 TLR4 TNF
35 psoriatic arthritis 29.4 HLA-B IL6 PTPN22 TNF
36 intermediate uveitis 29.3 HLA-B IL2RA IL6 TNF
37 acquired immunodeficiency syndrome 29.3 HLA-B IL2RA IL6 TNF
38 inflammatory bowel disease 29.2 HLA-B IL6 PTPN22 TLR2 TLR4 TNF
39 common variable immunodeficiency 29.1 IL2RA IL6 TLR2 TNF
40 vogt-koyanagi-harada disease 29.1 HLA-A HLA-B IL2RA PTPN22
41 rheumatoid arthritis 28.9 HLA-B IL2RA IL6 PTPN22 TLR2 TLR4
42 diabetes mellitus 28.8 HLA-A HLA-B IL2RA IL6 PTPN22 TNF
43 systemic lupus erythematosus 28.4 CFH IL2RA IL6 PTPN22 TLR2 TLR4
44 infectious anterior uveitis 12.4
45 idiopathic anterior uveitis 12.4
46 fuchs' heterochromic uveitis 12.2
47 lens-induced iridocyclitis 12.2
48 gonococcal iridocyclitis 12.1
49 phacoanaphylactic uveitis 11.5
50 blau syndrome 11.1

Graphical network of the top 20 diseases related to Anterior Uveitis:



Diseases related to Anterior Uveitis
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Symptoms & Phenotypes for Anterior Uveitis

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GenomeRNAi Phenotypes related to Anterior Uveitis according to GeneCards Suite gene sharing:

26 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.85 HLA-A HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.85 HLA-A HLA-B
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.85 IL2RA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.85 HLA-A HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.85 IL2RA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.85 IL2RA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.85 IL2RA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.85 HLA-A HLA-B
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.85 IL2RA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.85 IL2RA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.85 HLA-A HLA-B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.85 IL2RA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.85 HLA-A HLA-B IL2RA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.85 IL2RA
15 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.85 IL2RA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.85 IL2RA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.85 HLA-A HLA-B
18 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.85 IL2RA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.85 IL2RA
20 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.85 IL2RA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.85 IL2RA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.85 HLA-A HLA-B
23 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.85 HLA-A HLA-B
24 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.85 IL2RA

MGI Mouse Phenotypes related to Anterior Uveitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.88 CFH IL6 PTPN22 TLR2 TLR4 TNF
2 hematopoietic system MP:0005397 9.87 CFH IL2RA IL6 PTPN22 TLR2 TLR4
3 digestive/alimentary MP:0005381 9.85 IL2RA IL6 PTPN22 TLR2 TLR4 TNF
4 immune system MP:0005387 9.8 CFH IL2RA IL6 PTPN22 TLR2 TLR4
5 liver/biliary system MP:0005370 9.55 IL6 PTPN22 TLR2 TLR4 TNF
6 renal/urinary system MP:0005367 9.35 CFH IL6 PTPN22 TLR2 TLR4
7 respiratory system MP:0005388 9.1 IL2RA IL6 PTPN22 TLR2 TLR4 TNF
Sources

Drugs & Therapeutics for Anterior Uveitis

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Drugs for Anterior Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 109)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4,Phase 3 331731-18-1 16219006
2
Ganciclovir Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 82410-32-0 3454
3
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
5
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
6
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
7
Acyclovir Approved Phase 4,Phase 3 59277-89-3 2022
8
leucovorin Approved Phase 4,Not Applicable 58-05-9 6006 143
9
Methotrexate Approved Phase 4,Not Applicable 59-05-2, 1959-05-2 126941
10
Dinoprost Tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
11
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
12
Dinoprost Approved, Investigational Phase 4 551-11-1 5283078
13
Difluprednate Approved Phase 4,Phase 3,Phase 2 23674-86-4 443936
14
Certolizumab pegol Approved Phase 4,Phase 3 428863-50-7
15
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 59-30-3 6037
16
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2920-86-7
17 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 Antirheumatic Agents Phase 4,Phase 3,Not Applicable
22 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Ganciclovir triphosphate Phase 4,Phase 2,Phase 3,Not Applicable
24 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Not Applicable
25 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Immunologic Factors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
27 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Prednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Methylprednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Vitamin B9 Phase 4,Not Applicable
31 Antimetabolites Phase 4,Not Applicable
32 Antimetabolites, Antineoplastic Phase 4,Not Applicable
33 Folic Acid Antagonists Phase 4,Not Applicable
34 Vitamin B Complex Phase 4,Not Applicable
35 Folate Phase 4,Not Applicable
36 Dermatologic Agents Phase 4,Phase 3,Not Applicable
37 beta-endorphin Phase 4,Not Applicable
38 Adrenocorticotropic Hormone Phase 4,Not Applicable
39 Melanocyte-Stimulating Hormones Phase 4,Not Applicable
40 Lubricant Eye Drops Phase 4
41 Antihypertensive Agents Phase 4
42 Benzalkonium Compounds Phase 4,Phase 3
43 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Anti-Infective Agents, Local Phase 4,Phase 3
45 Oxytocics Phase 4
46 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 valacyclovir Phase 4
48
Ranibizumab Approved Phase 2, Phase 3 347396-82-1 459903
49
Etanercept Approved, Investigational Phase 3,Not Applicable 185243-69-0
50
Fluprednisolone Approved Phase 3,Phase 2 53-34-9

Interventional clinical trials:

(show top 50) (show all 67)
# Name Status NCT ID Phase Drugs
1 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
2 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
3 A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment Completed NCT02897115 Phase 4
4 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4 2% guttae ganciclovir
5 A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU Active, not recruiting NCT03020992 Phase 4 Certolizumab Pegol
6 A Randomized Trial of Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis Not yet recruiting NCT03626376 Phase 4 oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily;oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily + topical corticosteroid eye drops
7 Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis Terminated NCT02769702 Phase 4 Acthar
8 Methotrexate in the Treatment of Axial Spondyloarthritis Withdrawn NCT00298012 Phase 4 Methotrexate
9 Herpetic Eye Disease Study (HEDS) I Unknown status NCT00000138 Phase 3 Prednisolone Phosphate;Acyclovir
10 Double-dose Ranibizumab for Polypoidal Choroidal Vasculopathy Unknown status NCT02769169 Phase 2, Phase 3 Lucentis® (Raibizumab) double-dose;Lucentis® (Raibizumab) regular-dose
11 Safety and Efficacy of Difluprednate 0.05% for the Treatment of Anterior Uveitis Completed NCT01201798 Phase 3 Difluprednate 0.05% ophthalmic emulsion;Prednisolone acetate 1.0% ophthalmic suspension
12 A Multi-center Study to Assess the Efficacy and Safety of LX211 in Active Non-infectious Anterior Uveitis Completed NCT00404885 Phase 3 Placebo;LX211;LX211;LX211
13 Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Non-Infectious Anterior Uveitis Completed NCT02517619 Phase 3 Dexamethasone Phosphate Ophthalmic Solution;Prednisolone Acetate Ophthalmic (1%)
14 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00406887 Phase 3 Difluprednate Ophthalmic Emulsion
15 Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis Completed NCT01505088 Phase 3 40 mg/mL Dexamethasone phosphate ophthalmic solution;Prednisolone Acetate (1%) Eyedrops;100 mM sodium citrate buffer solution;Placebo Eyedrops
16 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Severe Uveitis Completed NCT00407056 Phase 3 Difluprednate Ophthalmic Emulsion
17 Study of Difluprednate in the Treatment of Uveitis Completed NCT00501579 Phase 3 Difluprednate;Prednisolone Acetate
18 A Study of the Long-term Safety and Efficacy of Adalimumab in Subjects With Intermediate-, Posterior-, or Pan-uveitis Completed NCT01148225 Phase 3 adalimumab
19 Herpetic Eye Disease Study (HEDS) II Completed NCT00000139 Phase 3 Acyclovir
20 Suprachoroidal Injection of CLS-TA in Subjects Non-infectious Uveitis Completed NCT03097315 Phase 3
21 Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis Completed NCT02595398 Phase 3 4mg CLS-TA Suprachoriodal Injection;Sham Procedure
22 CLARITY Extension Study Completed NCT00641537 Phase 3 Cladribine;Placebo;Cladribine;Cladribine;Placebo
23 A Study of Ixekizumab (LY2439821) in bDMARD-Naive Participants With Radiographic Axial Spondyloarthritis Completed NCT02696785 Phase 3 Ixekizumab;Placebo;Adalimumab
24 SOLACE Trial - A Phase 3 Trial in Subjects With Non-infectious Anterior-uveitis. Recruiting NCT03131154 Phase 3 ADX-102 Ophthalmic Solution (0.5%);Vehicle of ADX-102 Ophthalmic Solution
25 Treatment Tapering in JIA With Inactive Disease Recruiting NCT02840175 Phase 3 etanercept;adalimumab;Abatacept;Tocilizumab
26 A Long Term Extension Study of Ixekizumab (LY2439821) in Participants With Axial Spondyloarthritis Recruiting NCT03129100 Phase 3 Ixekizumab;Placebo
27 A Study of Ixekizumab (LY2439821) in Participants With Nonradiographic Axial Spondyloarthritis Active, not recruiting NCT02757352 Phase 3 Ixekizumab;Placebo
28 A Study of Ixekizumab (LY2439821) in TNF Inhibitor Experienced Participants With Radiographic Axial Spondyloarthritis Active, not recruiting NCT02696798 Phase 3 Ixekizumab;Placebo
29 Multicenter Study Evaluating Certolizumab Pegol Compared to Placebo in Subjects With axSpA Without X-ray Evidence of AS Active, not recruiting NCT02552212 Phase 3
30 Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis: Treatment Outcomes Not yet recruiting NCT03586284 Phase 2, Phase 3 Valganciclovir Hydrochloride;Ganciclovir Sodium;Placebo Oral Tablet;Topical placebo
31 Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis Not yet recruiting NCT03576898 Phase 2, Phase 3 Topical ganciclovir versus oral valganciclovir versus placebo
32 A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Anterior Uveitis Terminated NCT00333996 Phase 2, Phase 3 Dexamethasone
33 Proof of Concept Study to Evaluate Safety and Efficacy of LME636 in the Treatment of Acute Anterior Uveitis Completed NCT02482129 Phase 2 LME636 60 mg/mL ophthalmic solution;Dexamethasone 0.1% ophthalmic solution;LME636 Vehicle
34 A Safety and Efficacy Study of NS2 in Patients With Anterior Uveitis Completed NCT02406209 Phase 2 NS2;Prednisolone acetate ophthalmic suspension (1%)
35 Safety and Efficacy Study of DSP-Visulex for the Treatment of Anterior Uveitis Completed NCT02309385 Phase 1, Phase 2 8% Dexamethasone Sodium Phosphate - Visulex;15% Dexamethasone Sodium Phosphate - Visulex;Prednisolone Acetate (1%) Eye Drops
36 Exploratory Study on Topical ESBA105 in Acute Anterior Uveitis Completed NCT00823173 Phase 2
37 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00405496 Phase 2 Difluprednate Ophthalmic Emulsion
38 Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis Completed NCT00130637 Phase 2 Daclizumab
39 Safety and Efficacy Study of Iontophoresis and Dexamethasone Phosphate to Treat Anterior Uveitis Completed NCT00694135 Phase 2 EGP-437 1.6 mA-min at 0.4 with EyeGate® II System;EGP-437 4.8 mA-min at 1.2 mA with EyeGate® II System;EGP-437 10.0 mA-min at 2.5 mA with EyeGate® II System;EGP-437 14.0 mA-min at 3.5 mA with EyeGate® II System
40 Topical Interferon Gamma for Macular Edema Secondary to Uveitis Completed NCT01376362 Phase 1, Phase 2 Interferon Gamma-1b
41 Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis Completed NCT02255032 Phase 2 4 mg CLS-TA;0.8 mg CLS-TA
42 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2 AIN457;AIN 457;AIN457
43 A Phase I/IIa Study for the Treatment of Uveitis With Iontophoresis Withdrawn NCT00499551 Phase 1, Phase 2
44 Subconjunctival Sirolimus for the Treatment of Autoimmune Active Anterior Uveiti Completed NCT00876434 Phase 1 Sirolimus
45 Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Withdrawn NCT02042027 Phase 1 Gamunex-C
46 Acute Anterior Uveitis: Psychic Burden and Pain Unknown status NCT01156285
47 Clinical Outcomes of Topical Ganciclovir Treatment in Cytomegalovirus Anterior Uveitis Unknown status NCT01486693
48 Variations in Retinal Nerve Fiber Layer Thickness During Uncomplicated Anterior and Intermediate Uveitis Unknown status NCT02879084
49 Etanercept: Single Blind Control Study in Ocular Manifestations of Behcet's Disease Unknown status NCT00931957 Not Applicable Etanercept, Methotrexate, Prednisolone
50 Quality of Life and Visual Function in Uveitis Patients Unknown status NCT00407316

Search NIH Clinical Center for Anterior Uveitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :
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Genetic Tests for Anterior Uveitis

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Anatomical Context for Anterior Uveitis

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MalaCards organs/tissues related to Anterior Uveitis:

41
Eye, Endothelial, T Cells, Bone, Prostate, Lung, Spinal Cord
Sources

Publications for Anterior Uveitis

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Articles related to Anterior Uveitis:

(show top 50) (show all 917)
# Title Authors Year
1
Inflammatory bowel disease and acute anterior uveitis, but not psoriasis are associated with disease duration in Axial SpA: results from the (Be)Giant and ASPECT cohort. ( 29740978 )
2018
2
Diagnosis of Cytomegalovirus Anterior Uveitis in Two European Referral Centers. ( 29377783 )
2018
3
The pathogenic role of dendritic cells in non-infectious anterior uveitis. ( 29763582 )
2018
4
Increased Circulating Proinflammatory T Lymphocytes in Children with Different Forms of Anterior Uveitis: Results from a Pilot Study. ( 29771573 )
2018
5
Recurrent anterior uveitis and subsequent incidence of ankylosing spondylitis: a nationwide cohort study from 2002 to 2013. ( 29415753 )
2018
6
A study of the key genes and inflammatory signaling pathways involved in HLA-B27-associated acute anterior uveitis families. ( 29620146 )
2018
7
Clinical Characteristics of Herpes Simplex Virus Associated Anterior Uveitis. ( 29345511 )
2018
8
Elevated interleukin 37 expression associated with disease activity in HLA-B27 associated anterior uveitis and idiopathic anterior uveitis. ( 29424310 )
2018
9
Childhood Arthritis and Rheumatology Research Alliance consensus treatment plans for juvenile idiopathic arthritis-associated and idiopathic chronic anterior uveitis. ( 29806733 )
2018
10
Association of IL33 and IL1RAP polymorphisms with acute anterior uveitis. ( 29424312 )
2018
11
Clinical Features of CMV-Associated Anterior Uveitis. ( 29172842 )
2018
12
Immunopathology of Virus-Induced Anterior Uveitis. ( 29543540 )
2018
13
Hypertensive acute granulomatous anterior uveitis as a side effect of topical brimonidine. ( 29910082 )
2018
14
Tonic Pupil in Cytomegalovirus Anterior Uveitis in an Immunocompetent Adult Male - A Case Report. ( 29028408 )
2018
15
Multiplex Cytokine Analysis of Aqueous Humor in Juvenile Idiopathic Arthritis-Associated Anterior Uveitis With or Without Secondary Glaucoma. ( 29675026 )
2018
16
Prevalence of axial spondyloarthritis in patients with acute anterior uveitis: a cross-sectional study utilising MRI. ( 29531779 )
2018
17
PCR Multiplex for CMV Detection in Patients with Anterior Uveitis. ( 29474137 )
2018
18
Gut Microbiota Composition and Fecal Metabolic Phenotype in Patients With Acute Anterior Uveitis. ( 29625474 )
2018
19
Immunohistochemical characterization of feline lymphoplasmacytic anterior uveitis. ( 29517855 )
2018
20
Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis. ( 29511745 )
2018
21
Spondyloarthritis, Acute Anterior Uveitis, and Fungi: Updating the Catterall-King Hypothesis. ( 29675414 )
2018
22
Clinical features of patients with diabetic anterior uveitis. ( 29563110 )
2018
23
Syphilis-Related Eye Disease Presenting as Bilateral Papilledema, Retinal Nerve Fiber Layer Hemorrhage, and Anterior Uveitis in a Penicillin-Allergic Patient. ( 29670780 )
2018
24
Raised intracranial pressure with bilateral anterior uveitis. ( 29891509 )
2018
25
Chronic Anterior Uveitis in Children: Psychosocial Challenges for Patients and Their Families. ( 29601821 )
2018
26
Differential Diagnosis of Viral-Induced Anterior Uveitis. ( 29869892 )
2018
27
Choroidal thickness changes determined by EDI-OCT on acute anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis. ( 28197814 )
2018
28
Bilateral anterior uveitis and unilateral facial palsy due to ipilimumab for metastatic melanoma in an individual with human leukocyte antigen DR4: A case report. ( 28225147 )
2018
29
Orbital Inflammatory Syndrome and Anterior Uveitis: A Case Series. ( 28961042 )
2018
30
Anterior uveitis. ( 29290458 )
2018
31
Virus-Induced Anterior Uveitis (VIAU) in Immunocompromised Patients. ( 29969370 )
2018
32
Cytomegalovirus Anterior Uveitis: Clinical Characteristics and Long-term Outcomes in a French Series. ( 30055154 )
2018
33
The effect of methotrexate and sulfasalazine on the course of HLA-B27-positive anterior uveitis: results from a retrospective cohort study. ( 30069748 )
2018
34
Review for Disease of the Year: Treatment of Viral Anterior Uveitis: A Perspective. ( 30096015 )
2018
35
Requirement of longer term antiviral therapy in patients with cytomegalovirus anterior uveitis with corneal endothelial cell damage. ( 30100703 )
2018
36
The Phenotype of Monocytes in Anterior Uveitis Depends on the HLA-B27 Status. ( 30105034 )
2018
37
The Expression of Calprotectin and Factors in TLR4/NF-κB/MyD88 Pathway in Patients with Idiopathic Acute Anterior Uveitis. ( 30111215 )
2018
38
Bilateral anterior uveitis after immunotherapy for malignant melanoma. ( 30294532 )
2018
39
Novel gene targets for miRNA146a and miRNA155 in anterior uveitis. ( 30297336 )
2018
40
The microbiome and HLA-B27-associated acute anterior uveitis. ( 30301938 )
2018
41
Herpetic Anterior Uveitis - Analysis of Presumed and PCR Proven Cases. ( 30311824 )
2018
42
Aqueous humor analysis identifies higher branched chain amino acid metabolism as a marker for HLA-B27 acute anterior uveitis and disease activity. ( 30312576 )
2018
43
Discovery of tear biomarkers in children with chronic non-infectious anterior uveitis: a pilot study. ( 30327966 )
2018
44
Demystifying viral anterior uveitis: a review. ( 30345620 )
2018
45
Viral disease of the year: Anterior uveitis. ( 30353994 )
2018
46
Novel Dexamethasone Sodium Phosphate Treatment (DSP-Visulex) for Noninfectious Anterior Uveitis: A Randomized Phase I/II Clinical Trial. ( 30354530 )
2018
47
Reduced Occurrence Rate of Acute Anterior Uveitis in Ankylosing Spondylitis Treated with Golimumab - The GO-EASY Study. ( 30385705 )
2018
48
Aqueous tap and rapid diagnosis of cytomegalovirus anterior uveitis: the Reggio Emilia experience. ( 30392022 )
2018
49
The Management of Acute Anterior Uveitis Complicating Spondyloarthritis: Present and Future. ( 30406148 )
2018
50
Timing of infliximab and adalimumab initiation despite methotrexate in children with chronic non-infectious anterior uveitis. ( 30487588 )
2018
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Variations for Anterior Uveitis

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Expression for Anterior Uveitis

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Search GEO for disease gene expression data for Anterior Uveitis.
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Pathways for Anterior Uveitis

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Pathways related to Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.7 CFH HLA-A HLA-B IL2RA IL6 PTPN22
2
Class I MHC mediated antigen processing and presentation 66
Show member pathways
 13.28 HLA-A HLA-B PTPN22 TLR2 TLR4
3
Akt Signaling 64
Show member pathways
 13.23 IL2RA IL6 TLR2 TLR4 TNF
4
Cytokine Signaling in Immune system 66
Show member pathways
 13.18 HLA-A HLA-B IL2RA IL6 TNF
5
Human cytomegalovirus infection 37
Show member pathways
 12.87 HLA-A HLA-B IL6 TLR2 TLR4 TNF
6
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.85 IL6 TLR2 TLR4 TNF
7
Allograft rejection 1 37
Show member pathways
 12.74 HLA-A HLA-B IL2RA IL6 TNF
8
NF-KappaB Family Pathway 64
Show member pathways
 12.56 IL6 TLR2 TLR4 TNF
9
NF-kappaB Signaling 4
12.44 IL2RA PTPN22 TLR2 TNF
10
Th17 cell differentiation 37
Show member pathways
 12.43 IL2RA IL6 TLR2 TLR4 TNF
11
Antigen processing-Cross presentation 66
Show member pathways
 12.37 HLA-A HLA-B TLR2 TLR4
12
PI3K-Akt signaling pathway 37
Show member pathways
 12.34 HLA-A HLA-B IL2RA IL6 TLR2 TLR4
13
Endocytosis 37
12.26 HLA-A HLA-B IL2RA
14
IL-17 Family Signaling Pathways 65
Show member pathways
 12.19 IL6 TLR2 TNF
15
Toll Comparative Pathway 64
Show member pathways
 12.18 IL6 TLR4 TNF
16
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.17 IL6 TLR2 TLR4 TNF
17
Human T-cell leukemia virus 1 infection 37
12.17 HLA-A HLA-B IL2RA IL6 TNF
18
Proteoglycans in cancer 37
12.16 TLR2 TLR4 TNF
19
Tuberculosis 37
12.14 IL6 TLR2 TLR4 TNF
20
Toxoplasmosis 37
Show member pathways
 12.12 TLR2 TLR4 TNF
21
Bacterial infections in CF airways 22
Show member pathways
 12.09 IL6 TLR2 TLR4 TNF
22
IL-1 Family Signaling Pathways 65
Show member pathways
 12.08 IL6 TLR2 TNF
23
Colorectal Cancer Metastasis 64
12.08 IL6 TLR2 TLR4 TNF
24
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.08 HLA-A HLA-B IL2RA IL6 TNF
25
Cellular senescence (KEGG) 37
12.04 HLA-A HLA-B IL6
26
Phagosome 37
12.03 HLA-A HLA-B TLR2 TLR4
27
Epstein-Barr virus infection 37
12.02 HLA-A HLA-B IL6 TLR2 TNF
28
Th1 Differentiation Pathway 65
Show member pathways
 11.95 IL6 TLR2 TLR4 TNF
29
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 11.93 IL6 TLR2 TLR4 TNF
30
MAPK Pathway 72
Show member pathways
 11.92 IL2RA TLR2 TLR4
31
Spinal Cord Injury 1
11.9 IL6 TLR4 TNF
32
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.88 IL2RA IL6 TNF
33
Influenza A 37
Show member pathways
 11.86 HLA-A HLA-B IL2RA IL6 TLR2 TLR4
34
Hematopoietic cell lineage 37
11.8 IL2RA IL6 TNF
35
Amoebiasis 37
11.72 IL6 TLR2 TLR4 TNF
36
Pertussis 37
11.68 IL6 TLR4 TNF
37
Rheumatoid arthritis 37
11.66 IL6 TLR2 TLR4 TNF
38
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.57 HLA-A IL2RA TNF
39
MSP-RON Signaling 64
11.46 TLR2 TLR4 TNF
40
IL-10 Pathway 64
11.3 IL6 TLR4 TNF
41
Legionellosis 37
11.3 IL6 TLR2 TLR4 TNF
42
African trypanosomiasis 37
11.24 IL6 TNF
43
Development and heterogeneity of the ILC family 1
11.2 IL6 TNF
44
Antifolate resistance 37
11.18 IL6 TNF
45
Malaria 37
11.15 IL6 TLR2 TLR4 TNF
46
Cytokines and Inflammatory Response 1
11.14 IL6 TNF
47
Antigen Presentation- Folding, assembly and peptide loading of class I MHC 66
11.07 HLA-A HLA-B
48
Transcription factor regulation in adipogenesis 1
11.01 IL6 TNF
49
Overview of nanoparticle effects 1
10.93 IL6 TNF
Sources

GO Terms for Anterior Uveitis

About this section

Cellular components related to Anterior Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.72 HLA-A HLA-B TLR2 TLR4 TNF
2 intrinsic component of plasma membrane GO:0031226 9.37 TLR2 TLR4
3 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-A HLA-B
4 MHC class I protein complex GO:0042612 9.16 HLA-A HLA-B
5 phagocytic vesicle membrane GO:0030670 9.13 HLA-A HLA-B TLR2
6 cell surface GO:0009986 9.1 HLA-A HLA-B IL2RA TLR2 TLR4 TNF

Biological processes related to Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.89 IL6 TLR2 TLR4 TNF
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.85 PTPN22 TLR4 TNF
3 positive regulation of gene expression GO:0010628 9.83 IL6 PTPN22 TLR2 TLR4 TNF
4 response to lipopolysaccharide GO:0032496 9.81 PTPN22 TLR2 TLR4
5 cellular response to lipopolysaccharide GO:0071222 9.8 IL6 TLR4 TNF
6 immune system process GO:0002376 9.8 HLA-A HLA-B IL2RA PTPN22 TLR2 TLR4
7 defense response to Gram-positive bacterium GO:0050830 9.74 IL6 TLR2 TNF
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.71 IL6 TLR2 TLR4 TNF
9 positive regulation of inflammatory response GO:0050729 9.7 TLR2 TLR4 TNF
10 toll-like receptor signaling pathway GO:0002224 9.68 TLR2 TLR4
11 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.67 TLR2 TLR4
12 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.67 HLA-A HLA-B
13 negative regulation of interleukin-6 production GO:0032715 9.66 TLR4 TNF
14 positive regulation of interferon-beta production GO:0032728 9.66 TLR2 TLR4
15 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.65 HLA-A HLA-B
16 negative regulation of neurogenesis GO:0050768 9.65 IL6 TNF
17 positive regulation of interleukin-12 production GO:0032735 9.65 TLR2 TLR4
18 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.65 TLR2 TLR4 TNF
19 positive regulation of interleukin-10 production GO:0032733 9.64 TLR2 TLR4
20 positive regulation of T cell mediated cytotoxicity GO:0001916 9.64 HLA-A HLA-B
21 microglial cell activation GO:0001774 9.62 TLR2 TNF
22 positive regulation of glial cell proliferation GO:0060252 9.62 IL6 TNF
23 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.61 TLR2 TLR4
24 regulation of cytokine secretion GO:0050707 9.61 TLR2 TLR4
25 I-kappaB phosphorylation GO:0007252 9.6 TLR2 TLR4
26 cellular response to lipoteichoic acid GO:0071223 9.58 TLR2 TLR4
27 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.58 TLR4 TNF
28 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.56 HLA-A HLA-B
29 positive regulation of interleukin-6 production GO:0032755 9.56 IL6 TLR2 TLR4 TNF
30 negative regulation of lipid storage GO:0010888 9.55 IL6 TNF
31 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.54 HLA-A HLA-B
32 positive regulation of interleukin-8 production GO:0032757 9.54 TLR2 TLR4 TNF
33 positive regulation of neuroinflammatory response GO:0150078 9.51 IL6 TNF
34 protection from natural killer cell mediated cytotoxicity GO:0042270 9.49 HLA-A HLA-B
35 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.46 TLR2 TLR4
36 lipopolysaccharide-mediated signaling pathway GO:0031663 9.46 PTPN22 TLR2 TLR4 TNF
37 positive regulation of chemokine production GO:0032722 9.26 IL6 TLR2 TLR4 TNF
38 immune response GO:0006955 9.17 HLA-A HLA-B IL2RA IL6 TLR2 TLR4

Molecular functions related to Anterior Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 9.16 TLR2 TLR4
2 peptide antigen binding GO:0042605 8.96 HLA-A HLA-B
3 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4
Sources

Sources for Anterior Uveitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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