MCID: ANT019
MIFTS: 37

Anterograde Amnesia

Categories: Mental diseases, Neuronal diseases
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Aliases & Classifications for Anterograde Amnesia

MalaCards integrated aliases for Anterograde Amnesia:

Name: Anterograde Amnesia 11 75 14 31
Amnesia, Anterograde 75 43 71

Classifications:



External Ids:

Disease Ontology 11 DOID:5340
MeSH 43 D020324
SNOMED-CT 68 88822006
ICD10 31 R41.1
UMLS 71 C0233795

Summaries for Anterograde Amnesia

Disease Ontology: 11 An amnestic disorder that involves the impaired or lost ability to memorize new things.

MalaCards based summary: Anterograde Amnesia, also known as amnesia, anterograde, is related to amnestic disorder and retrograde amnesia. An important gene associated with Anterograde Amnesia is PRODH (Proline Dehydrogenase 1), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Neuroscience. The drugs Bupivacaine and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and temporal lobe, and related phenotypes are nervous system and growth/size/body region

Wikipedia: 75 In neurology, anterograde amnesia is the inability to create new memories after the event that caused... more...

Related Diseases for Anterograde Amnesia

Diseases related to Anterograde Amnesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 187)
# Related Disease Score Top Affiliating Genes
1 amnestic disorder 31.4 TSPO LGI1 HTR1A FOS CNTNAP2 BDNF
2 retrograde amnesia 31.4 LGI1 HTR1A FOS EGR1 CA4 BDNF
3 dissociative amnesia 30.2 LGI1 CNTNAP2 CA4 BDNF AK5
4 encephalitis 30.2 TSPO PNMA2 LGI1 CNTNAP2 AMPH
5 somatoform disorder 30.2 HTR1A FOS BDNF
6 acute stress disorder 30.1 GAD2 BDNF
7 transient global amnesia 30.0 LGI1 CNTNAP2 CA4 AK5
8 limbic encephalitis 29.8 PNMA2 LGI1 GAD2 DPYSL5 CNTNAP2 AMPH
9 wernicke encephalopathy 29.8 TSPO PNMA2
10 substance abuse 29.4 PRODH HTR1A HCRT GRM5 FOS BDNF
11 alcohol dependence 29.0 TSPO HTR1A GRM5 GAD2 BDNF
12 stiff-person syndrome 28.8 TSPO PNMA2 LGI1 GAD2 DPYSL5 CNTNAP2
13 temporal lobe epilepsy 28.7 TSPO LGI1 HTR1A GRM5 GAD2 BDNF
14 major depressive disorder 28.5 TSPO HTR1A HCRT GAD2 FOS BDNF
15 hhv-6 encephalitis 11.2
16 posttransplant acute limbic encephalitis 11.2
17 wernicke-korsakoff syndrome 10.4
18 akinetic mutism 10.3 PNMA2 LGI1
19 auditory agnosia 10.3 LGI1 CNTNAP2
20 cyclothymic disorder 10.3 HTR1A BDNF
21 fallopian tube serous adenocarcinoma 10.3 PNMA2 AMPH
22 melancholia 10.3 HTR1A BDNF
23 atypical depressive disorder 10.2 HTR1A BDNF
24 vascular myelopathy 10.2 DPYSL5 AMPH
25 delusional disorder 10.2 PRODH HTR1A
26 cerebellopontine angle meningioma 10.2 DPYSL5 AMPH
27 neurotic disorder 10.2 HTR1A BDNF
28 hypochondriasis 10.2 HTR1A BDNF
29 traumatic brain injury 10.2
30 multiple personality disorder 10.2 PRODH CA4
31 tic disorder 10.2 PRODH HTR1A CNTNAP2
32 partial motor epilepsy 10.2 LGI1 CNTNAP2
33 schizophreniform disorder 10.2 PRODH BDNF
34 substance-induced psychosis 10.2 PRODH HTR1A BDNF
35 cannabis abuse 10.2 PRODH HTR1A BDNF
36 bipolar i disorder 10.2 PRODH HTR1A BDNF
37 paranoid schizophrenia 10.2 PRODH HTR1A BDNF
38 agoraphobia 10.2 PRODH HTR1A BDNF
39 social phobia 10.2 PRODH HTR1A BDNF
40 premature ejaculation 10.2 HTR1A BDNF
41 childhood disintegrative disease 10.2 CNTNAP2 BDNF
42 dissociative disorder 10.2 CA4 BDNF
43 schizoaffective disorder 10.2 PRODH HTR1A BDNF
44 mental depression 10.2 PRODH HTR1A BDNF
45 whipple disease 10.2 PNMA2 LGI1 DPYSL5
46 learning disability 10.2 PRODH CNTNAP2 BDNF
47 autoimmune neuropathy 10.2 LGI1 DPYSL5 CNTNAP2
48 cocaine abuse 10.1 HTR1A FOS BDNF
49 cranial nerve disease 10.1 LGI1 DPYSL5 BDNF
50 glioma susceptibility 1 10.1

Graphical network of the top 20 diseases related to Anterograde Amnesia:



Diseases related to Anterograde Amnesia

Symptoms & Phenotypes for Anterograde Amnesia

MGI Mouse Phenotypes related to Anterograde Amnesia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.1 AMPH APOE BDNF CNTNAP2 DPYSL5 EGR1
2 growth/size/body region MP:0005378 9.93 APOE BDNF CA4 CNTNAP2 EGR1 FOS
3 behavior/neurological MP:0005386 9.83 AMPH APOE BDNF CA4 CNTNAP2 DPYSL5
4 reproductive system MP:0005389 9.32 AMPH APOE BDNF CA4 EGR1 FOS

Drugs & Therapeutics for Anterograde Amnesia

Drugs for Anterograde Amnesia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
2
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
3
Midazolam Approved, Illicit 59467-70-8 4192
4
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
5
Tannic acid Approved 1401-55-4 16129878 16129778
6 Neurotransmitter Agents
7 Anti-Anxiety Agents
8 Psychotropic Drugs
9 Anesthetics, Intravenous
10 Anesthetics, General
11 Anesthetics
12 Hypnotics and Sedatives
13 GABA Modulators
14 Anesthetics, Local

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Midazolam's Anterograde Amnesia Efficacy in Noisy Orthopedic Surgery: Does Midazolam Cause Effective Anterograde Amnesia in Noisy Orthopedic Surgeries? Completed NCT04232150 single-dose midazolam for sedation under spinal anesthesia.;Double-dose midazolam for sedation under spinal anesthesia.
2 A Randomized Controlled Clinical Trial of Remimazolam Benzenesulfonate Usage in the Extraction of Impacted Wisdom Teeth Recruiting NCT05350085 Remimazolam besylate;Midazolam

Search NIH Clinical Center for Anterograde Amnesia

Cochrane evidence based reviews: amnesia, anterograde

Genetic Tests for Anterograde Amnesia

Anatomical Context for Anterograde Amnesia

Organs/tissues related to Anterograde Amnesia:

MalaCards : Cortex, Brain, Temporal Lobe, Thalamus, Amygdala, Caudate Nucleus, Prefrontal Cortex

Publications for Anterograde Amnesia

Articles related to Anterograde Amnesia:

(show top 50) (show all 969)
# Title Authors PMID Year
1
DNA methylation inhibition participates in the anterograde amnesia key mechanism through the suppression of the transcription of genes involved in memory formation in grape snails. 62
36116736 2023
2
Subcortical signal alteration of corticospinal tracts. A radiologic manifestation of ARIA: A case report. 62
36388611 2023
3
Diencephalic versus Hippocampal Amnesia in Alzheimer's Disease: The Possible Confabulation-Misidentification Phenotype. 62
36442200 2022
4
Comparative Study of the Effect of a DNA Methyltransferase Inhibitor and a Histone Deacetylase Inhibitor on Memory Formation Processes in Anterograde Amnesia. 62
36437324 2022
5
Distorted time perception in patients with transient global amnesia: time perception task and imaging analysis. 62
35849197 2022
6
Life-long deficits in social adaptation and the frontal lobes: New evidence, seventy-five years after Ackerly and Benton's landmark case report of JP. 62
36403380 2022
7
Effects of Chronic Oral Administration of Midazolam on Memory and Circadian Rhythms in Rats. 62
36302539 2022
8
Pineal cyst apoplexy and memory loss: a novel complication. 62
35965931 2022
9
Safe sedation during diagnostic and therapeutic flexible bronchoscopy in Japan: A review of the literature. 62
36220691 2022
10
Nonparaneoplastic Anti-GAD Limbic Encephalitis: Seizure Outcome and Long-term Neuropsychological Follow-up After Immunotherapy. 62
35856876 2022
11
Transient Global Amnesia Masquerading as Transient Ischemic Attack. 62
36299968 2022
12
Hippocampal infarction: redefining transient global amnesia. 62
35244830 2022
13
Forgetting the Unforgettable: Transient Global Amnesia Part II: A Clinical Road Map. 62
35887703 2022
14
Bilateral Acute Hippocampal Ischemia in Two Patients Abusing Cocaine: What is the Outcome? 62
35915690 2022
15
Prosopamnesia: a case report of amnesia for faces. 62
35695794 2022
16
Largely intact memory for spatial locations during navigation in an individual with dense amnesia. 62
35367237 2022
17
Forgetting the Unforgettable: Transient Global Amnesia Part I: Pathophysiology and Etiology. 62
35743444 2022
18
Stiff Person Syndrome and Encephalitis with GAD Antibodies with Severe Anterograde Amnesia in an Adolescent: A Case Study and Literature Review. 62
34905789 2022
19
Transient global amnesia: Model, mechanism, hypothesis. 62
35228100 2022
20
The Role of DNA Methylation and Activity of Neurotransmitter Receptors in the Mechanisms of Specific Anterograde Amnesia and Memory Recovery. 62
35348960 2022
21
A case of anterograde amnesia in an MS-like demyelination after COVID-19. 62
34661785 2022
22
Anti-AK5 encephalitis: subacute anterograde amnesia is not the only clinical presentation. 62
35040073 2022
23
Recurrent amnesia caused by early seizures after hippocampal infarction: a case report. 62
35012472 2022
24
Transient Global Amnesia. 62
35029951 2022
25
COVID-19 Vaccine-Associated Transient Global Amnesia: A Disproportionality Analysis of the WHO Safety Database. 62
35668936 2022
26
Digital dementia in the internet generation: excessive screen time during brain development will increase the risk of Alzheimer's disease and related dementias in adulthood. 62
35164464 2022
27
A Neuropsychological Rehabilitation Framework to Address Cognitive and Neurobehavioral Impairments After Strokes to the Anterior Communicating Artery. 62
35754764 2022
28
Hemorrhagic cavum vergae colloid cyst: A presentation of anterograde amnesia without hydrocephalus. 62
35509582 2022
29
A New Hypothesis for Alzheimer's Disease: The Lipid Invasion Model. 62
35530118 2022
30
[Autoimmune encephalitis : an update]. 62
35258262 2022
31
Basal Forebrain Impairment: Understanding the Mnemonic Function of the Septal Region Translates in Therapeutic Advances. 62
35712645 2022
32
Cerebellar Ischemia Presenting as Transient Global Amnesia. 62
34851869 2021
33
The effect of remimazolam on postoperative memory retention and delayed regeneration in breast surgery patients: Rationale and design of an exploratory, randomized, open, propofol-controlled, single-center clinical trial: A study protocol. 62
35049181 2021
34
"Vascular" Korsakoff Syndrome With Bilaterally Damaged Mammillothalamic Tracts: Insights Into the Pathogenesis of "Acute" Korsakoff Syndrome As Acute-Onset Irreversible Anterograde Amnesia. 62
34912613 2021
35
Immediate retrograde amnesia induced by midazolam: A prospective, non-randomised cohort study. 62
34037290 2021
36
Opioid-Associated Amnestic Syndrome. 62
34877229 2021
37
Primary phlebitis of central nervous system revealed by black-blood magnetic resonance imaging. 62
34645637 2021
38
Who Are You? The Study of Personality in Patients With Anterograde Amnesia. 62
34520287 2021
39
Safe Administration of ECT in a Suicidal Patient With a Space-Occupying Astrocytoma. 62
33625177 2021
40
Paradoxical Reactions to Midazolam in a Term Parturient After Intravenous Sedation During Cesarean Section. 62
34513535 2021
41
Detection of γ-hydroxybutyric acid-related acids in blood plasma and urine: Extending the detection window of an exogenous γ-hydroxybutyric acid intake? 62
33991073 2021
42
Ozone-induced encephalopathy: A novel iatrogenic entity. 62
33657263 2021
43
Paraneoplastic limbic encephalitis as initial presentation of testicular neoplasm: A case report. 62
33556762 2021
44
Immediate retrograde amnesia induced by midazolam: a prospective, nonrandomized cohort study. 62
34431173 2021
45
Isoflurane Suppresses Hippocampal High-frequency Ripples by Differentially Modulating Pyramidal Neurons and Interneurons in Mice. 62
33951177 2021
46
Acute Amnestic Syndrome and Ischemic Stroke: A Case Series. 62
34484894 2021
47
A case of transient global amnesia with hippocampal infarction due to infective endocarditis. 62
33485796 2021
48
A reappraisal of acute doses of benzodiazepines as a model of anterograde amnesia. 62
33368617 2021
49
Transient global amnesia after radiofrequency catheter ablation of supraventricular tachycardia: a case report. 62
33968625 2021
50
Indications for Computed Tomography in Older Adult Patients With Minor Head Injury in the Emergency Department. 62
32815620 2021

Variations for Anterograde Amnesia

Expression for Anterograde Amnesia

Search GEO for disease gene expression data for Anterograde Amnesia.

Pathways for Anterograde Amnesia

Pathways related to Anterograde Amnesia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.21 GRM5 FOS BDNF AK5
2 11.7 HTR1A HCRT GRM5 GAD2 EGR1 CNTNAP2
3 11.69 GRM5 FOS BDNF
4 11.53 TSPO HTR1A APOE
5 11.19 FOS EGR1 BDNF
6 10.39 GRM5 GAD2

GO Terms for Anterograde Amnesia

Biological processes related to Anterograde Amnesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.32 HTR1A HCRT GRM5 GAD2 AMPH
2 sleep GO:0030431 9.26 HCRT FOS

Sources for Anterograde Amnesia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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