MCID: ANT019
MIFTS: 38

Anterograde Amnesia

Categories: Mental diseases

Aliases & Classifications for Anterograde Amnesia

MalaCards integrated aliases for Anterograde Amnesia:

Name: Anterograde Amnesia 12 73 15 32
Amnesia, Anterograde 73 44 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5340
MeSH 44 D020324
SNOMED-CT 67 88822006
ICD10 32 R41.1
UMLS 70 C0233795

Summaries for Anterograde Amnesia

Disease Ontology : 12 An amnestic disorder that involves the impaired or lost ability to memorize new things.

MalaCards based summary : Anterograde Amnesia, also known as amnesia, anterograde, is related to retrograde amnesia and dissociative amnesia. An important gene associated with Anterograde Amnesia is LGI1 (Leucine Rich Glioma Inactivated 1), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and cAMP signaling pathway. The drugs Midazolam and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include cortex, temporal lobe and brain, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Wikipedia : 73 Anterograde amnesia is a loss of the ability to create new memories after the event that caused amnesia,... more...

Related Diseases for Anterograde Amnesia

Diseases related to Anterograde Amnesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 retrograde amnesia 31.1 LGI1 HTR1A GRIN2B FOS EGR1 CA4
2 dissociative amnesia 30.7 LGI1 CNTNAP2
3 amnestic disorder 30.6 TSPO LGI1 HTR1A GRIN2B FOS CNTNAP2
4 encephalitis 30.4 TSPO PNMA2 LGI1 CNTNAP2
5 transient global amnesia 30.4 CA4 BDNF
6 autoimmune encephalitis 30.4 LGI1 CNTNAP2
7 acute stress disorder 30.3 HTR1A BDNF
8 traumatic brain injury 30.3 BDNF APOE
9 brain injury 30.2 BDNF APOE
10 mental depression 30.1 HTR1A GRIN2B BDNF
11 wernicke encephalopathy 30.0 TSPO PNMA2
12 limbic encephalitis 29.7 PNMA2 LGI1 GRIN2B DPYSL5 CNTNAP2 AMPH
13 migraine with or without aura 1 29.4 HTR1A GRM5 GRIN2B FOS BDNF
14 alcohol dependence 29.2 TSPO HTR1A GRM5 GRIN2B BDNF
15 major depressive disorder 29.0 HTR1A GRM5 GRIN2B BDNF APOE
16 hhv-6 encephalitis 11.2
17 cortical deafness 10.3 LGI1 BDNF
18 vascular myelopathy 10.3 DPYSL5 AMPH
19 atypical depressive disorder 10.3 HTR1A BDNF
20 partial optic atrophy 10.3 DPYSL5 AMPH
21 neurotic disorder 10.3 HTR1A BDNF
22 plexopathy 10.3 DPYSL5 AMPH
23 hypochondriasis 10.3 HTR1A BDNF
24 whipple disease 10.3 PNMA2 DPYSL5
25 postinfectious encephalitis 10.3 LGI1 CNTNAP2
26 anal spasm 10.3 DPYSL5 AMPH
27 autosomal dominant epilepsy with auditory features 10.2 LGI1 CNTNAP2
28 chorea gravidarum 10.2 DPYSL5 CNTNAP2
29 wernicke-korsakoff syndrome 10.2
30 cerebellopontine angle tumor 10.2 DPYSL5 CNTNAP2
31 neuromuscular junction disease 10.2 LGI1 DPYSL5 AMPH
32 dissociative disorder 10.2 GRIN2B BDNF
33 cannabis abuse 10.2 HTR1A BDNF
34 childhood disintegrative disease 10.2 CNTNAP2 BDNF
35 mutism 10.2 PNMA2 LGI1 CNTNAP2
36 acute disseminated encephalomyelitis 10.2 PNMA2 LGI1 CNTNAP2
37 melancholia 10.2 HTR1A BDNF
38 autoimmune neuropathy 10.2 DPYSL5 CNTNAP2
39 trigeminal nerve disease 10.1 FOS BDNF
40 phobia, specific 10.1 HTR1A BDNF
41 miller fisher syndrome 10.1 PNMA2 CNTNAP2 AMPH
42 pain agnosia 10.1 HTR1A FOS BDNF
43 motion sickness 10.1 HTR1A FOS
44 glioma susceptibility 1 10.1
45 ocular motor apraxia 10.1
46 aortic dissection 10.1
47 malignant astrocytoma 10.1
48 subacute delirium 10.1
49 encephalopathy 10.1
50 head injury 10.1

Graphical network of the top 20 diseases related to Anterograde Amnesia:



Diseases related to Anterograde Amnesia

Symptoms & Phenotypes for Anterograde Amnesia

MGI Mouse Phenotypes related to Anterograde Amnesia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.17 AMPH APOE BDNF CA4 CNTNAP2 DPYSL5
2 endocrine/exocrine gland MP:0005379 9.86 AMPH APOE BDNF EGR1 FOS FOXB1
3 nervous system MP:0003631 9.77 AMPH APOE BDNF CNTNAP2 DPYSL5 EGR1
4 integument MP:0010771 9.76 APOE BDNF CNTNAP2 EGR1 FOS FOXB1
5 reproductive system MP:0005389 9.28 AMPH APOE BDNF CA4 EGR1 FOS

Drugs & Therapeutics for Anterograde Amnesia

Drugs for Anterograde Amnesia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit 59467-70-8 4192
2
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
3
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
4
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
5
Imidacloprid Vet_approved 105827-78-9 86418
6 Psychotropic Drugs
7 Neurotransmitter Agents
8 GABA Modulators
9 Anti-Anxiety Agents
10 Hypnotics and Sedatives
11 Anesthetics, General
12 Anesthetics
13 Anesthetics, Intravenous

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Does Midazolam Cause Effective Anterograde Amnesia in Noisy Orthopedic Surgeries? Completed NCT04232150 single-dose midazolam for sedation under spinal anesthesia.;Double-dose midazolam for sedation under spinal anesthesia.
2 A Multicenter, Randomized, Single-blind, Parallel Controlled Clinical Study on the Efficacy and Safety of Remimazolam Tosylate for Sedation in Gastroscopy Recruiting NCT04727034 Remimazolam tosylate;Propofol

Search NIH Clinical Center for Anterograde Amnesia

Cochrane evidence based reviews: amnesia, anterograde

Genetic Tests for Anterograde Amnesia

Anatomical Context for Anterograde Amnesia

MalaCards organs/tissues related to Anterograde Amnesia:

40
Cortex, Temporal Lobe, Brain, Thalamus, Amygdala, Bone Marrow, Prefrontal Cortex

Publications for Anterograde Amnesia

Articles related to Anterograde Amnesia:

(show top 50) (show all 920)
# Title Authors PMID Year
1
What Causes Anterograde Amnesia? 61
33794519 2021
2
Ozone-induced encephalopathy: A novel iatrogenic entity. 61
33657263 2021
3
Human Herpesvirus 6 Encephalitis in Immunocompetent and Immunocompromised Hosts. 61
33587722 2021
4
Paraneoplastic limbic encephalitis as initial presentation of testicular neoplasm: A case report. 61
33556762 2021
5
Safe Administration of ECT in a Suicidal Patient With a Space-Occupying Astrocytoma. 61
33625177 2021
6
Loss of Consciousness is Associated with Elevated Cognitive Intra-Individual Variability Following Sports-Related Concussion. 61
32772944 2021
7
Prevalence of Mimics and Severe Comorbidity in Patients with Clinically Suspected Transient Global Amnesia. 61
33412553 2021
8
A case of transient global amnesia with hippocampal infarction due to infective endocarditis. 61
33485796 2021
9
Complete Bilateral Hippocampal Diffusion Restriction and Reversible Amnesia Following Opiate, Cocaine, and Benzodiazepine Abuse. 61
33585137 2021
10
In search of the 'self': Holistic rehabilitation in restoring cognition and recovering the 'self' following traumatic brain injury: A case report. 61
33664160 2021
11
A Study of the Participation of NMDA Glutamate Receptors in the Mechanisms of Specific Anterograde Amnesia Reversion. 61
33269451 2020
12
Anterograde Amnesia as a Manifestation of Acute Type A Aortic Dissection. 61
33268979 2020
13
Psychiatric symptoms in anti glutamic acid decarboxylase associated limbic encephalitis in adults: a systematic review. 61
33022299 2020
14
A reappraisal of acute doses of benzodiazepines as a model of anterograde amnesia. 61
33368617 2020
15
Neuropsychological and neuropathological observations of a long-studied case of memory impairment. 61
33168712 2020
16
Optimizing and simplifying post-traumatic amnesia testing after moderate-severe traumatic brain injury despite common confounders in routine practice. 61
33222946 2020
17
Transient Global Amnesia: A Diffusion and Perfusion MRI study. 61
32598567 2020
18
Hypertrophic Olivary Degeneration and Movement Disorder in a Patient with Familial Creutzfeldt-Jakob Disease. 61
33178508 2020
19
Wernicke Encephalopathy as a Complication of Hyperemesis Gravidarum: Case Report. 61
33129223 2020
20
Dissecting the Fornix in Basic Memory Processes and Neuropsychiatric Disease: A Review. 61
32567331 2020
21
Deconstructing the Direct Reciprocal Hippocampal-Anterior Thalamic Pathways for Spatial Learning. 61
32753513 2020
22
Indications for Computed Tomography in Older Adult Patients With Minor Head Injury in the Emergency Department. 61
32815620 2020
23
Factors Associated With Risk of Recurrent Transient Global Amnesia. 61
32865551 2020
24
Four patients with infarction in key areas of the Papez circuit, with anterograde amnesia as the main manifestation. 61
32686968 2020
25
Transient amnesia following prehospital low-dose ketamine administration. 61
32317201 2020
26
Wakeful rest benefits before and after encoding in anterograde amnesia. 61
32237872 2020
27
Long-term outcomes in temporal lobe epilepsy with glutamate decarboxylase antibodies. 61
32221776 2020
28
Acute amnestic syndromes. 61
32203745 2020
29
Time trends, frequency, characteristics and prognosis of short-duration transient global amnesia. 61
32012408 2020
30
A Teenager With Acute Anterograde Amnesia. 61
29346236 2020
31
Transient global amnesia following transoesophageal echocardiography. 61
32350056 2020
32
Neuropathology of a remarkable case of memory impairment informs human memory. 61
31972232 2020
33
Bilateral Fornical Columns Infarction Secondary to an Arteriovenous Malformation Embolization. 61
31790837 2020
34
[Application of intravenous sedation in 2 582 cases of oral and maxillofacial surgery]. 61
32071484 2020
35
Effects of magnetic seizure therapy on anterograde and retrograde amnesia in treatment-resistant depression. 61
31682325 2020
36
Long-term memory consolidation or reconsolidation impairment induces amnesia with key characteristics that are similar to key learning characteristics. 61
31811833 2020
37
Transient Global Amnesia in a Patient Presenting with Hypertensive Emergency; a Case Report. 61
33134962 2020
38
New Long-Term Encoding in Severely Amnesic Alzheimer's Disease Patients Revealed Through Repeated Exposure to Artistic Items. 61
32675409 2020
39
Synaptic Correlates of Anterograde Amnesia and Intact Retrograde Memory in a Mouse Model of Alzheimer's Disease. 61
32091333 2020
40
Toward refining Alzheimer's disease into overlapping subgroups. 61
32885025 2020
41
Two Cases of Late-Onset Anti-NMDAr Auto-Immune Encephalitis After Herpes Simplex Virus 1 Encephalitis. 61
32132963 2020
42
Pure topographical disorientation in novel environments without anterograde amnesia: a case study. 61
31298073 2019
43
[A case of recurrent transient global amnesia showing different symptom duration and MRI findings]. 61
31474643 2019
44
Retrosplenial cortex damage produces retrograde and anterograde context amnesia using strong fear conditioning procedures. 61
31039379 2019
45
Transient Global Amnesia in a 60-year-old female with Post-traumatic Stress Disorder. 61
31728239 2019
46
Prolonged anterograde amnesia and disorientation after anterior communicating artery aneurysm coil embolisation. 61
31366616 2019
47
Psychoprophylaxis for oral conscious sedation for dental care in Down syndrome adults with behavioral disorder. 61
31050376 2019
48
Teaching NeuroImages: Persistent anterograde amnesia due to sequential, bilateral vascular damage to the Papez circuit. 61
31182522 2019
49
Abnormal EEG Power Spectra in Acute Transient Global Amnesia: A Quantitative EEG Study. 61
29877098 2019
50
Brief Motivational Interventions Are Associated with Reductions in Alcohol-Induced Blackouts Among Heavy Drinking College Students. 61
30973651 2019

Variations for Anterograde Amnesia

Expression for Anterograde Amnesia

Search GEO for disease gene expression data for Anterograde Amnesia.

Pathways for Anterograde Amnesia

Pathways related to Anterograde Amnesia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.14 GRM5 GRIN2B FOS BDNF AK5
2 11.89 HTR1A GRIN2B FOS BDNF
3 11.68 TSPO HTR1A APOE
4 11.63 HTR1A GRM5 GRIN2B EGR1 CNTNAP2 APOE
5 11.62 FOS EGR1 BDNF
6
Show member pathways
11.57 GRIN2B FOS BDNF
7 11.42 GRIN2B FOS EGR1 BDNF

GO Terms for Anterograde Amnesia

Cellular components related to Anterograde Amnesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.02 HTR1A DPYSL5 CNTNAP2 BDNF APOE
2 synaptic cleft GO:0043083 8.96 LGI1 APOE

Biological processes related to Anterograde Amnesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 9.5 FOXB1 BDNF APOE
2 neuron projection development GO:0031175 9.43 LGI1 CNTNAP2 APOE
3 chemical synaptic transmission GO:0007268 9.26 HTR1A GRM5 GRIN2B AMPH
4 thalamus development GO:0021794 9.16 FOXB1 CNTNAP2
5 positive regulation of neuron death GO:1901216 8.8 GRIN2B FOS EGR1

Sources for Anterograde Amnesia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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