MCID: ANT019
MIFTS: 38

Anterograde Amnesia

Categories: Mental diseases

Aliases & Classifications for Anterograde Amnesia

MalaCards integrated aliases for Anterograde Amnesia:

Name: Anterograde Amnesia 12 74 15 32
Amnesia, Anterograde 74 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5340
MeSH 43 D020324
SNOMED-CT 67 88822006
ICD10 32 R41.1
UMLS 71 C0233795

Summaries for Anterograde Amnesia

Disease Ontology : 12 An amnestic disorder that involves the impaired or lost ability to memorize new things.

MalaCards based summary : Anterograde Amnesia, also known as amnesia, anterograde, is related to dissociative amnesia and amnestic disorder. An important gene associated with Anterograde Amnesia is PRODH (Proline Dehydrogenase 1), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and cAMP signaling pathway. The drugs Midazolam and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and temporal lobe, and related phenotypes are behavior/neurological and nervous system

Wikipedia : 74 Anterograde amnesia is a loss of the ability to create new memories after the event that caused amnesia,... more...

Related Diseases for Anterograde Amnesia

Diseases related to Anterograde Amnesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 dissociative amnesia 30.7 LGI1 CNTNAP2
2 amnestic disorder 30.6 LGI1 IMPACT HTR1A GRIN2B GABRR3 FOS
3 encephalitis 30.4 PNMA2 LGI1 CNTNAP2 AMPH
4 substance abuse 30.4 PRODH HTR1A BDNF
5 autoimmune encephalitis 30.3 LGI1 CNTNAP2
6 transient global amnesia 30.2 LGI1 CA4 BDNF
7 acute stress disorder 30.1 GABRR3 BDNF
8 retrograde amnesia 30.0 TNFRSF10C IMPACT HTR1A GRIN2B FOS EGR1
9 limbic encephalitis 29.8 PNMA2 LGI1 GRIN2B AMPH AK5
10 mental depression 29.6 PRODH HTR1A GRIN2B BDNF
11 alcohol dependence 29.0 HTR1A GRM5 GRIN2B BDNF
12 hhv-6 encephalitis 11.8
13 substance-induced psychosis 10.4 PRODH HTR1A
14 cortical deafness 10.4 PNMA2 LGI1
15 internuclear ophthalmoplegia 10.4 LGI1 DPYSL5
16 atypical depressive disorder 10.3 HTR1A BDNF
17 traumatic brain injury 10.3
18 vascular myelopathy 10.3 DPYSL5 AMPH
19 partial optic atrophy 10.3 DPYSL5 AMPH
20 dysthymic disorder 10.3 PRODH HTR1A BDNF
21 social phobia 10.3 PRODH HTR1A BDNF
22 generalized anxiety disorder 10.2 PRODH HTR1A BDNF
23 plexopathy 10.2 DPYSL5 AMPH
24 schizoaffective disorder 10.2 PRODH HTR1A BDNF
25 barbiturate dependence 10.2 TNFRSF10C GABRR3
26 hypochondriasis 10.2 HTR1A BDNF
27 ocular motor apraxia 10.2
28 wernicke-korsakoff syndrome 10.2
29 astrocytoma 10.2
30 subacute delirium 10.2
31 encephalopathy 10.2
32 head injury 10.2
33 paraneoplastic limbic encephalitis 10.2
34 agraphia 10.2 PNMA2 ACHE
35 cerebellopontine angle meningioma 10.2 LGI1 DPYSL5 AMPH
36 autosomal dominant epilepsy with auditory features 10.2 LGI1 CNTNAP2
37 amblyopia 10.2 TNFRSF10C PRODH BDNF
38 vestibular nystagmus 10.1 TNFRSF10C FOS
39 cerebellar disease 10.1 PRODH DPYSL5 AMPH
40 tendinosis 10.1 BDNF ACHE
41 withdrawal disorder 10.1 HTR1A GABRR3 FOS
42 hematuria, benign familial 10.1 HTR1A GABRR3 FOS
43 agnosia 10.1 HTR1A FOS BDNF
44 tic disorder 10.1 PRODH HTR1A CNTNAP2
45 alzheimer disease 10.1
46 atrial standstill 1 10.1
47 autoimmune disease 10.1
48 teratoma, ovarian 10.1
49 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
50 frontotemporal dementia 10.1

Graphical network of the top 20 diseases related to Anterograde Amnesia:



Diseases related to Anterograde Amnesia

Symptoms & Phenotypes for Anterograde Amnesia

MGI Mouse Phenotypes related to Anterograde Amnesia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.73 ACHE AMPH BDNF CNTNAP2 DPYSL5 EGR1
2 nervous system MP:0003631 9.44 ACHE AMPH BDNF CNTNAP2 DPYSL5 EGR1

Drugs & Therapeutics for Anterograde Amnesia

Drugs for Anterograde Amnesia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
2
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
3
Meperidine Approved Phase 4 57-42-1 4058
4
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
5 Anti-Anxiety Agents Phase 4
6 Psychotropic Drugs Phase 4
7 GABA Modulators Phase 4
8 Neurotransmitter Agents Phase 4
9 Adrenergic alpha-Agonists Phase 4
10 Adrenergic Agents Phase 4
11 Analgesics, Non-Narcotic Phase 4
12 Analgesics Phase 4
13 Adrenergic Agonists Phase 4
14 Hypnotics and Sedatives Phase 4
15 Anesthetics, General Phase 4
16 Anesthetics Phase 4
17 Anesthetics, Intravenous Phase 4
18
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
19
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
20 Insulin, Globin Zinc
21 Mitogens
22 Estrogens
23 insulin
24 Hormones
25 Growth Hormone-Releasing Hormone

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Bronchoscopy Under Titrated Sedation With Propofol or Midazolam: a Randomized Trial. Completed NCT00839371 Phase 4 Propofol;Midazolam
2 Midazolam With Meperidine and Dexmedetomidine vs Midazolam With Meperidine for Sedation During ERCP Completed NCT01404689 Phase 4 Dexmedetomidine
3 Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes Active, not recruiting NCT00504894 Phase 4 Placebo;Propofol
4 Focal Electrical Administered Seizure Therapy (FEAST) for Major Depression Completed NCT01589315 Phase 2, Phase 3
5 Does Midazolam Cause Effective Anterograde Amnesia in Noisy Orthopedic Surgeries? Completed NCT04232150 single-dose midazolam for sedation under spinal anesthesia.;Double-dose midazolam for sedation under spinal anesthesia.
6 Reversible Cerebral Vasoconstriction Syndrome With Concomitant Transient Global Amnesia : a Serie of 3 Cases Report Completed NCT03739008
7 Age-Related Sleep Impairment - Treatment w/GHRH Completed NCT00000380 GHRH
8 Effect of Midazolam Premedication Before Induction on the Functional Recovery After General Anesthesia in the Patients Undergoing Breast Surgery Due to Breast Cancer Completed NCT01945476 midazolam premedication
9 The Effect on Cognition of Terminating ECT Induced Seizures With Propofol Completed NCT00616759 propofol
10 Hippocampal Sclerosis and Amnesia Not Due to Alzheimer's Disease Recruiting NCT02576821
11 Feasibility and Limited Efficacy Trial of a Cognitive Behavioral Intervention to Reduce Procedural Anxiety Among Woman With High Risk Pregnancies With Scheduled Cesarean Deliveries Recruiting NCT04203082

Search NIH Clinical Center for Anterograde Amnesia

Cochrane evidence based reviews: amnesia, anterograde

Genetic Tests for Anterograde Amnesia

Anatomical Context for Anterograde Amnesia

MalaCards organs/tissues related to Anterograde Amnesia:

40
Cortex, Brain, Temporal Lobe, Amygdala, Breast, Testes, Thalamus

Publications for Anterograde Amnesia

Articles related to Anterograde Amnesia:

(show top 50) (show all 894)
# Title Authors PMID Year
1
Acute amnestic syndromes. 61
32203745 2020
2
Dissecting the fornix in basic memory processes and neuropsychiatric disease: A review. 61
32567331 2020
3
Time trends, frequency, characteristics and prognosis of short-duration transient global amnesia. 61
32012408 2020
4
A Teenager With Acute Anterograde Amnesia. 61
29346236 2020
5
Wakeful rest benefits before and after encoding in anterograde amnesia. 61
32237872 2020
6
Transient Amnesia Following Prehospital Low-dose Ketamine Administration. 61
32317201 2020
7
Transient global amnesia following transoesophageal echocardiography. 61
32350056 2020
8
Neuropathology of a remarkable case of memory impairment informs human memory. 61
31972232 2020
9
Bilateral Fornical Columns Infarction Secondary to an Arteriovenous Malformation Embolization. 61
31790837 2020
10
Long-term outcomes in temporal lobe epilepsy with glutamate decarboxylase antibodies. 61
32221776 2020
11
Effects of magnetic seizure therapy on anterograde and retrograde amnesia in treatment-resistant depression. 61
31682325 2020
12
[Application of intravenous sedation in 2 582 cases of oral and maxillofacial surgery]. 61
32071484 2020
13
Synaptic Correlates of Anterograde Amnesia and Intact Retrograde Memory in a Mouse Model of Alzheimer's Disease. 61
32091333 2020
14
Long-term memory consolidation or reconsolidation impairment induces amnesia with key characteristics that are similar to key learning characteristics. 61
31811833 2020
15
Two Cases of Late-Onset Anti-NMDAr Auto-Immune Encephalitis After Herpes Simplex Virus 1 Encephalitis. 61
32132963 2020
16
Pure topographical disorientation in novel environments without anterograde amnesia: a case study. 61
31298073 2019
17
Retrosplenial cortex damage produces retrograde and anterograde context amnesia using strong fear conditioning procedures. 61
31039379 2019
18
[A case of recurrent transient global amnesia showing different symptom duration and MRI findings]. 61
31474643 2019
19
Transient Global Amnesia in a 60-year-old female with Post-traumatic Stress Disorder. 61
31728239 2019
20
Prolonged anterograde amnesia and disorientation after anterior communicating artery aneurysm coil embolisation. 61
31366616 2019
21
Psychoprophylaxis for oral conscious sedation for dental care in Down syndrome adults with behavioral disorder. 61
31050376 2019
22
Teaching NeuroImages: Persistent anterograde amnesia due to sequential, bilateral vascular damage to the Papez circuit. 61
31182522 2019
23
Abnormal EEG Power Spectra in Acute Transient Global Amnesia: A Quantitative EEG Study. 61
29877098 2019
24
Brief Motivational Interventions Are Associated with Reductions in Alcohol-Induced Blackouts Among Heavy Drinking College Students. 61
30973651 2019
25
Saturday night retinopathy and anterograde amnesia due to fentanyl overdose. 61
31041135 2019
26
Comparative Analysis of Intravenous Midazolam with Nasal Spray for Conscious Sedation in Minor Oral and Maxillofacial Surgeries. 61
30923430 2019
27
Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation. 61
31233568 2019
28
Space and Memory (Far) Beyond the Hippocampus: Many Subcortical Structures Also Support Cognitive Mapping and Mnemonic Processing. 61
31447653 2019
29
Enhanced cortisol secretion in acute transient global amnesia. 61
30193207 2019
30
Limbic encephalitis: Experience of a moroccan center. 61
30474361 2019
31
Isolated seizures are a common early feature of paraneoplastic anti-GABAB receptor encephalitis. 61
30460450 2019
32
Thiamine Substitution in Alcohol Use Disorder: A Narrative Review of Medical Guidelines. 61
30897571 2019
33
Paraneoplastic limbic encephalitis revealing a small cell carcinoma of the lung. 61
30622890 2019
34
Retrograde Autobiographical Memory From PTA Emergence to Six-Month Follow-Up in Moderate to Severe Traumatic Brain Injury. 61
30404534 2019
35
Cognitive and affective theory of mind in Korsakoff's syndrome. 61
30558689 2018
36
College student knowledge of blackouts and implications for alcohol intervention: A qualitative analysis. 61
30359045 2018
37
Isolated Mammillary Bodies Damage-An Atypical Presentation of Wernicke Syndrome. 61
30424509 2018
38
Isolated Fornix Infarction with Damage to the Limbic System as a Cause of Persistent Amnesia: A Case Report. 61
30459298 2018
39
Temporary Memory Steal: Transient Global Amnesia Secondary to Nephrolithiasis. 61
30443620 2018
40
Retrograde amnesia after intravenous sedation and general anaesthesia in a dental hospital. 61
30029983 2018
41
The Rhesus Monkey Hippocampus Critically Contributes to Scene Memory Retrieval, But Not New Learning. 61
30049888 2018
42
Network supporting contextual fear learning after dorsal hippocampal damage has increased dependence on retrosplenial cortex. 61
30086129 2018
43
[Psychogenic Retrograde and Anterograde Amnesia]. 61
29997276 2018
44
Intraventricular extension of an aneurysmal subarachnoid hemorrhage is an independent predictor of a worse functional outcome. 61
29730271 2018
45
Behavioral evidence suggestive of frontal lobe pathology in the amnesic H.M. 61
29573701 2018
46
[Patient satisfaction with procedural sedation in oral and -maxillofacial surgery]. 61
29754157 2018
47
Tako-tsubo cardiomyopathy with transient global amnesia and cerebellar embolic stroke triggered by existential fear. 61
29720346 2018
48
Anterograde Amnesia after Acute Glufosinate Ammonium Intoxication. 61
31723872 2018
49
Knowledge and learning of verb biases in amnesia. 61
29775775 2018
50
Persistent anterograde amnesia due to the artery of Percheron occlusion: a case report. 61
29606081 2018

Variations for Anterograde Amnesia

Expression for Anterograde Amnesia

Search GEO for disease gene expression data for Anterograde Amnesia.

Pathways for Anterograde Amnesia

Pathways related to Anterograde Amnesia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.14 GRM5 GRIN2B FOS BDNF AK5
2 11.89 HTR1A GRIN2B FOS BDNF
3 11.89 HTR1A GRM5 GRIN2B EGR1 CNTNAP2
4 11.62 FOS EGR1 BDNF
5
Show member pathways
11.57 GRIN2B FOS BDNF
6 11.08 GRIN2B FOS EGR1 BDNF

GO Terms for Anterograde Amnesia

Cellular components related to Anterograde Amnesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.55 TNFRSF10C GRIN2B CNTNAP2 CA4 ACHE
2 cell junction GO:0030054 9.43 LGI1 GRIN2B GABRR3 CNTNAP2 AMPH ACHE
3 synaptic cleft GO:0043083 9.26 LGI1 ACHE
4 synapse GO:0045202 9.1 LGI1 HTR1A GRIN2B GABRR3 AMPH ACHE

Biological processes related to Anterograde Amnesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 learning or memory GO:0007611 9.5 GRM5 GRIN2B BDNF
2 nervous system development GO:0007399 9.43 LGI1 IMPACT FOS DPYSL5 BDNF ACHE
3 positive regulation of neuron death GO:1901216 9.33 GRIN2B FOS EGR1
4 neuron recognition GO:0008038 9.26 CNTNAP2 BDNF
5 chemical synaptic transmission GO:0007268 9.02 HTR1A GRM5 GRIN2B GABRR3 AMPH

Sources for Anterograde Amnesia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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