MCID: ANT001
MIFTS: 37

Anterolateral Myocardial Infarction

Categories: Cardiovascular diseases

Aliases & Classifications for Anterolateral Myocardial Infarction

MalaCards integrated aliases for Anterolateral Myocardial Infarction:

Name: Anterolateral Myocardial Infarction 12 15 17 74
Anterior Wall Myocardial Infarction 45
Anterior Myocardial Infarction 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5845
MeSH 45 D056988

Summaries for Anterolateral Myocardial Infarction

MalaCards based summary : Anterolateral Myocardial Infarction, also known as anterior wall myocardial infarction, is related to cardiogenic shock and cardiac rupture. An important gene associated with Anterolateral Myocardial Infarction is CHKB (Choline Kinase Beta), and among its related pathways/superpathways are A-beta Pathways: Plaque Formation and APP Metabolism and Cardiomyocyte Differentiation through BMP Receptors. The drugs Atorvastatin and Hydroxymethylglutaryl-CoA Reductase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and brain, and related phenotype is homeostasis/metabolism.

Related Diseases for Anterolateral Myocardial Infarction

Diseases in the Anterolateral Myocardial Infarction family:

Acute Anterolateral Myocardial Infarction

Diseases related to Anterolateral Myocardial Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 cardiogenic shock 30.2 NPPB PLAT
2 cardiac rupture 30.2 CHKB PLAT
3 angina pectoris 30.1 ACE NPPB PLAT
4 left bundle branch hemiblock 30.0 ACE NPPB SULT1E1
5 myocardial infarction 30.0 ACE CHKB NPPA NPPB PLAT
6 pulmonary edema 29.8 ACE NPPA NPPB
7 arteries, anomalies of 29.8 ACE NPPB PLAT
8 dilated cardiomyopathy 29.5 ACE CHKB NPPA NPPB
9 coronary artery anomaly 29.4 ACE NPPA NPPB PLAT
10 atrial fibrillation 29.4 ACE NPPA NPPB PLAT
11 mitral valve insufficiency 29.3 ACE NPPA NPPB SULT1E1
12 acute anterolateral myocardial infarction 12.7
13 depression 10.3
14 testicular torsion 10.2 ACE CHKB
15 sleep apnea 10.2 ACE NPPB
16 lipodystrophy, familial partial, type 4 10.2 ACE PLIN1
17 ischemic heart disease 10.2 ACE NPPB
18 aortic valve insufficiency 10.2 ACE NPPB
19 central sleep apnea 10.2 NPPA NPPB
20 renal hypertension 10.2 ACE NPPB
21 systolic heart failure 10.2 ACE NPPB
22 acute cor pulmonale 10.1 NPPB PLAT
23 mitral valve stenosis 10.1 NPPA NPPB
24 acute pulmonary heart disease 10.1 NPPB PLAT
25 syncope 10.1 NPPA NPPB
26 hypoaldosteronism 10.1 ACE NPPA
27 hypertensive heart disease 10.1 ACE NPPB
28 heart conduction disease 10.1 ACE NPPB
29 vasculogenic impotence 10.1 ACE NPPA
30 ischemia 10.1
31 coronary stenosis 10.1 ACE NPPB
32 pulmonary hypertension, primary, 1 10.1 NPPA NPPB
33 oligohydramnios 10.1 ACE NPPB
34 hepatorenal syndrome 10.1 ACE NPPA
35 intermediate coronary syndrome 10.1 ACE PLAT
36 pure autonomic failure 10.1 ACE NPPA
37 hemorrhage, intracerebral 10.1 ACE PLAT
38 renovascular hypertension 10.1 ACE NPPA
39 hypoplastic left heart syndrome 10.0 NPPA NPPB
40 mitral valve disease 10.0 ACE NPPA
41 pulmonary embolism 10.0 NPPB PLAT
42 posterior myocardial infarction 10.0 PLAT SULT1E1
43 pericardial effusion 10.0 CHKB NPPA NPPB
44 progressive familial heart block, type ia 10.0
45 progressive familial heart block, type ib 10.0
46 atrioventricular block 10.0
47 second-degree atrioventricular block 10.0
48 right bundle branch block 10.0
49 myocarditis 10.0
50 chagas disease 10.0 ACE NPPB

Graphical network of the top 20 diseases related to Anterolateral Myocardial Infarction:



Diseases related to Anterolateral Myocardial Infarction

Symptoms & Phenotypes for Anterolateral Myocardial Infarction

MGI Mouse Phenotypes related to Anterolateral Myocardial Infarction:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.17 ACE CHKB IRF1 NPPA PLAT PLIN1

Drugs & Therapeutics for Anterolateral Myocardial Infarction

Drugs for Anterolateral Myocardial Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 91)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Atorvastatin Approved Phase 4 134523-00-5 60823
2 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
3 Antimetabolites Phase 4,Phase 2,Phase 3
4 Hypolipidemic Agents Phase 4
5 Anticholesteremic Agents Phase 4
6 Lipid Regulating Agents Phase 4
7
Warfarin Approved Phase 3,Not Applicable 81-81-2 6691 54678486
8
Methotrexate Approved Phase 2, Phase 3 1959-05-2, 59-05-2 126941
9
leucovorin Approved Phase 2, Phase 3 58-05-9 6006 143
10
Apixaban Approved Phase 3 503612-47-3 10182969
11
Phylloquinone Approved, Investigational Phase 3 84-80-0
12
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
13
Calcifediol Approved, Nutraceutical Phase 3 19356-17-3 5283731 6433735
14
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
15
Ergocalciferol Approved, Nutraceutical Phase 3 50-14-6 5280793
16
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
17
Menadione Approved, Nutraceutical Phase 3 58-27-5 4055
18
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
19 Immunologic Factors Phase 2, Phase 3,Not Applicable
20 Antirheumatic Agents Phase 2, Phase 3,Not Applicable
21 Anticoagulants Phase 3,Not Applicable
22 Calcium, Dietary Phase 3
23 Micronutrients Phase 3,Phase 2
24 Vitamins Phase 3,Phase 2
25 Trace Elements Phase 3,Phase 2
26 Hormones Phase 3
27 Nutrients Phase 3,Phase 2
28 Ergocalciferols Phase 3
29 Vitamin D2 Phase 3
30 Calciferol Phase 3
31 Bone Density Conservation Agents Phase 3
32 Hematinics Phase 2, Phase 3
33 Vitamin B Complex Phase 2, Phase 3
34 Immunosuppressive Agents Phase 2, Phase 3
35 Folic Acid Antagonists Phase 2, Phase 3
36 Dermatologic Agents Phase 2, Phase 3
37 Antimetabolites, Antineoplastic Phase 2, Phase 3
38 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
39 Folate Phase 2, Phase 3
40 Vitamin B9 Phase 2, Phase 3
41 Antithrombin III Phase 3
42 Factor Xa Inhibitors Phase 3
43 Serine Proteinase Inhibitors Phase 3
44 Menaquinone Phase 3
45 Antithrombins Phase 3
46 Vitamin K Phase 3
47 naphthoquinone Phase 3
48
protease inhibitors Phase 3,Phase 2
49 HIV Protease Inhibitors Phase 3,Phase 2
50
Lenograstim Approved, Investigational Phase 2,Not Applicable 135968-09-1

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 Effects of Intensive Statin Treatment on Left Ventricular Function Unknown status NCT01936103 Phase 4 standard group;intensive group
2 Efficacy of Endovascular Catheter Cooling Combined With Cold Saline for the Treatment of Acute Myocardial Infarction Completed NCT01379261 Phase 2, Phase 3
3 Acute Myocardial Infarction With HyperOxemic Therapy II (AMIHOT II) Completed NCT00175058 Phase 3
4 Effect of Vitamin D on Ventricular Remodeling in Patients With Acute Myocardial Infarction (VITDAMI) Recruiting NCT02548364 Phase 3 Calcifediol;Placebo
5 Effect of Methotrexate Carried by a Lipid Nanoemulsion on Left Ventricular Remodeling After STEMI Recruiting NCT03516903 Phase 2, Phase 3 Methotrexate;Placebo;Folic Acid
6 Apixaban Versus Warfarin in Patients With Left Ventricular (LV) Thrombus Not yet recruiting NCT03232398 Phase 3 Apixaban Oral Tablet [Eliquis];Warfarin
7 Bone Marrow Derived Adult Stem Cells for Acute Anterior Myocardial Infarction Unknown status NCT00765453 Phase 2
8 RIGENERA 2.0 Trial Unknown status NCT02502747 Phase 2 rhu G-CSF;optimal standard of care
9 Autologous Stem Cell Transplantation in Acute Myocardial Infarction Completed NCT00199823 Phase 2
10 Nesiritide Therapy to Preserve Function of the Left Ventricle After Myocardial Infarction Completed NCT00573144 Phase 2 Nesiritide;Placebo
11 Cell-Wave Study: Combined Extracorporal Shock Wave Therapy and Intracoronary Cell Therapy in Chronic Ischemic Myocardium Completed NCT00326989 Phase 1, Phase 2
12 Intracoronary Infusion of Bone Marrow Mononuclear Cells in Patients With Previous Myocardial Infarction. Completed NCT01454323 Phase 2
13 The Enhanced Angiogenic Cell Therapy - Acute Myocardial Infarction Trial Recruiting NCT00936819 Phase 2
14 Effect of Intravenous Metoprolol Combining RIPC on Myocardial Protection in STEMI Patients Recruiting NCT03579914 Phase 2 intravenous Placebo;Metoprolol Injectable Product
15 Safety Study of Allogeneic Mesenchymal Precursor Cell Infusion in MyoCardial Infarction Active, not recruiting NCT01781390 Phase 2
16 Firibastat or Ramipril After Acute Myocardial Infarction for Prevention of Left Ventricular Dysfunction Not yet recruiting NCT03715998 Phase 2 Ramipril;Firibastat
17 CD-NP (Cenderitide) Therapy for the Preservation of Left Ventricular Function Completed NCT02071602 Phase 1 CD-NP
18 Subclinical Hypothyroidism and Acute Anterior Myocardial Infarction: Is it Cardio-protective or Not? Unknown status NCT03017157
19 Myocardial Deformation in Real-time 3D Ultrasound. Normal Values in Adults and Validation Against the Tagged MRI Unknown status NCT02508727 Not Applicable
20 The Effect of Granulocyte Colony Stimulating Factor (G-CSF) on Myocardial Function After Acute Anterior Myocardial Infarction, a Prospective Double Blind Randomized Placebo Controlled Study Completed NCT00756756 Not Applicable G-CSF;placebo infusion of normal saline
21 The INFUSE - Anterior Myocardial Infarction (AMI) Study Completed NCT00976521 Not Applicable Abciximab local infusion
22 Rapid Intravascular Cooling in Myocardial Infarction as Adjunctive to Percutaneous Coronary Intervention Completed NCT00417638 Not Applicable
23 LV Thrombus Pilot Study for Comparing Enoxaparin Vs. Warfarin Completed NCT00321009 Not Applicable Enoxaparin
24 Warfarin After Anterior ST-Elevation Myocardial Infarction Completed NCT00662467 Not Applicable aspirin + clopidogrel;aspirin + clopidogrel + warfarin
25 COOL AMI EU Pilot Trial to Assess Cooling as an Adjunctive Therapy to Percutaneous Intervention in Patients With Acute Myocardial Infarction Completed NCT02509832 Not Applicable
26 MR, Myocardial Infarct and Heart Failure Completed NCT00465868
27 Effect of Diabetes and Hepatic Enzymes Mutation on Clopidogrel VS Ticagrelor Activity in Myocardial Infarction (MI) Patients Undergoing Primary Percutaneous Coronary Intervention (PCI) Completed NCT03613857 Clopidogrel;Ticagrelor 90mg
28 EARLY MVO Assessing Using QFR After STEMI Completed NCT03780335
29 Target Temperature Management In Myocardial Infarction - A Pilot Study Completed NCT01864343 Not Applicable
30 Cooling in Myocardial Infarction Completed NCT01777750 Not Applicable
31 Deferred Stenting in Patients With Anterior Wall STEMI Recruiting NCT03744000 Not Applicable
32 Collateral Circulation to LAD and Wellens Sign Recruiting NCT03707626
33 COOL-AMI EU Pivotal Trial Recruiting NCT03173313 Not Applicable
34 COmprehensive Remote Ischemic Conditioning in Myocardial Infarction Recruiting NCT03233919 Not Applicable
35 Hypothermia as an Adjunctive Therapy to Percutaneous Intervention in Patients With Acute Myocardial Infarction Recruiting NCT02664194 Not Applicable
36 The Intra-Aortic Balloon Pumps Insertion Registry on Behalf of the Groupe Des Angioplasticiens de la Région Ouest Active, not recruiting NCT02900456
37 Evaluation of Intracoronary Hyperoxemic Oxygen Therapy in Anterior Acute Myocardial Infarction Patients (IC-HOT) Active, not recruiting NCT02603835 Not Applicable
38 Pressure-controlled Intermittent Coronary Sinus Occlusion (PiCSO) in Acute Myocardial Infraction Not yet recruiting NCT03625869 Not Applicable
39 TandemHeart to Reduce Infarct Size (TRIS Trial) Withdrawn NCT02164058 Not Applicable

Search NIH Clinical Center for Anterolateral Myocardial Infarction

Cochrane evidence based reviews: anterior wall myocardial infarction

Genetic Tests for Anterolateral Myocardial Infarction

Anatomical Context for Anterolateral Myocardial Infarction

MalaCards organs/tissues related to Anterolateral Myocardial Infarction:

42
Bone, Bone Marrow, Brain, Heart

Publications for Anterolateral Myocardial Infarction

Articles related to Anterolateral Myocardial Infarction:

(show top 50) (show all 116)
# Title Authors Year
1
The established electrocardiographic classification of anterior wall myocardial infarction misguides clinicians in terms of infarct location, extent and prognosis. ( 30632651 )
2019
2
The significance of ST-elevation in aVL in anterolateral myocardial infarction: An assessment by cardiac magnetic resonance imaging. ( 29971868 )
2018
3
Deblurring the significance of ST-elevation in aVL in anterolateral myocardial infarction. ( 30242944 )
2018
4
A Simplified Formula Discriminating Subtle Anterior Wall Myocardial Infarction from Normal Variant ST-Segment Elevation. ( 30107901 )
2018
5
A case of spontaneous coronary artery dissection presenting with acute anterior wall myocardial infarction in a young adult male - an increasingly recognized rare disease. ( 29686789 )
2018
6
Galectin-3 and outcomes after anterior-wall myocardial infarction treated by primary percutaneous coronary intervention. ( 29243525 )
2018
7
Galectin-3 predicts left ventricular remodelling after anterior-wall myocardial infarction treated by primary percutaneous coronary intervention. ( 27465055 )
2017
8
Horizontal ECG in acute anterolateral myocardial infarction. ( 27271734 )
2016
9
Intra-aortic balloon pump insertion through the right subclavian artery in a patient of anterior wall myocardial infarction with ventricular septal rupture and severe peripheral artery obstruction disease. ( 24510603 )
2016
10
Delayed ventricular septal rupture complicating anterior wall myocardial infarction. ( 27932428 )
2016
11
Electrocardiographic prediction of lateral involvement in acute non-anterior wall myocardial infarction. ( 25766970 )
2015
12
A mimic of anterior wall myocardial infarction. ( 25817134 )
2015
13
The prognostic value of a prominent Q wave in lead (-)aVR in acute anterior wall myocardial infarction. ( 26363744 )
2015
14
Length of left anterior descending coronary artery determines prognosis in acute anterior wall myocardial infarction. ( 23625458 )
2014
15
Rituximab-vincristine chemotherapy-induced acute anterior wall myocardial infarction with cardiogenic shock. ( 24512409 )
2014
16
Granulocyte colony-stimulating factor therapy for stem cell mobilization following anterior wall myocardial infarction: the CAPITAL STEM MI randomized trial. ( 24934893 )
2014
17
Intra-aortic balloon pump treatment for patients with acute anterior wall myocardial infarction after reperfusion therapy. ( 25036172 )
2014
18
Mean platelet volume at admission is a determinant of left ventricular thrombus formation after primary percutaneous coronary intervention for first anterior wall myocardial infarction. ( 25643430 )
2014
19
Left ventricular thrombus in patients with acute anterior wall myocardial infarction. ( 25672172 )
2014
20
Cardioprotective Effects of Oral Trimetazidine in Diabetic Patients With Anterior Wall Myocardial Infarction Treated with Thrombolysis. ( 28392876 )
2014
21
Ventricular tachycardia unmasking anterior wall myocardial infarction in a patient with pre-existing left bundle branch block. ( 27326102 )
2013
22
Importance of total ischemic time and preprocedural infarct-related artery blood flow in predicting infarct size in patients with anterior wall myocardial infarction (from the CRISP-AMI Trial). ( 23768458 )
2013
23
Echocardiographic assessment of left atrial volume index in elderly patients with anterior wall myocardial infarction. ( 24482942 )
2013
24
Subacute anterior wall myocardial infarction complicated by intramyocardial dissection. ( 21570231 )
2012
25
Left main coronary artery aneurysm associated with anterior wall myocardial infarction. ( 30532861 )
2011
26
Sensitivity and specificity of frequently used electrocardiographic criteria for left ventricular hypertrophy in patients with anterior wall myocardial infarction. ( 20157497 )
2010
27
A national survey of Canadian practice patterns of warfarin after anterior wall myocardial infarction in the current era of dual antiplatelet therapy. ( 20538142 )
2010
28
Isolated inferior wall ST segment depression as an early sign of acute anterior wall myocardial infarction. ( 20954789 )
2010
29
Masquerade: fulminant viral myocarditis mimicking a Q-wave anterolateral myocardial infarction. ( 19486704 )
2009
30
Value of the 12-lead electrocardiogram to define the level of obstruction in acute anterior wall myocardial infarction: correlation to coronary angiography and clinical outcome in the DANAMI-2 trial. ( 18191483 )
2009
31
Combined assessment of myocardial perfusion and diastolic function enhances risk stratification in patients with anterior wall myocardial infarction. ( 19125809 )
2009
32
Six-month angiographic study of immediate autologous bone marrow mononuclear cell implantation on acute anterior wall myocardial infarction using a mini-pig model. ( 19367032 )
2009
33
Incidence of early left ventricular thrombus after acute anterior wall myocardial infarction in the primary coronary intervention era. ( 19464419 )
2009
34
Electrocardiographic change after recanalization in a patient with recent extensive anterior wall myocardial infarction. ( 19520380 )
2009
35
Determinants of left ventricular thrombus formation after primary percutaneous coronary intervention for anterior wall myocardial infarction. ( 17562128 )
2008
36
Intramyocardial dissection after subacute anterior wall myocardial infarction: an unusual form of myocardial rupture with subsequent spontaneous healing. ( 18269569 )
2008
37
Acute anterior wall myocardial infarction entailing ST-segment elevation in lead V3R, V1 or aVR: electrocardiographic and angiographic correlations. ( 18353349 )
2008
38
Relation between the assessment of microvascular injury by cardiovascular magnetic resonance and coronary Doppler flow velocity measurements in patients with acute anterior wall myocardial infarction. ( 18534269 )
2008
39
Assessment of left ventricular torsion in patients with anterior wall myocardial infarction before and after revascularization using speckle tracking imaging. ( 18982865 )
2008
40
Extensive anterolateral myocardial infarction caused by left main coronary artery dissection after blunt chest trauma: a case report. ( 17870504 )
2007
41
Anterolateral myocardial infarction induced by coronary-subclavian-vertebral steal syndrome successfully treated with stenting of the subclavian artery. ( 17712215 )
2007
42
Coexisting subarachnoid hemorrhage and subdural hematoma mimicking acute anterolateral myocardial infarction. ( 17604047 )
2007
43
Effect of microvascular reperfusion on prognosis and left ventricular function in anterior wall myocardial infarction treated with primary angioplasty. ( 16793152 )
2007
44
Association of haematological indices with the degree of microvascular injury in patients with acute anterior wall myocardial infarction treated with primary percutaneous coronary intervention. ( 16940390 )
2007
45
The assessment of left ventricular twist in anterior wall myocardial infarction using two-dimensional speckle tracking imaging. ( 17218200 )
2007
46
Early abciximab administration before primary percutaneous coronary intervention improves infarct-related artery patency and left ventricular function in high-risk patients with anterior wall myocardial infarction: a randomized study. ( 17307412 )
2007
47
Association of size of myocardial scar and persistence of ST-segment elevation after healing of anterior wall myocardial infarction. ( 17437736 )
2007
48
Determinants of ischemic mitral regurgitation in patients with chronic anterior wall myocardial infarction: a real time three-dimensional echocardiography study. ( 16970716 )
2006
49
Myocardial contrast echocardiographic estimates of infarct size predict likelihood of left ventricular remodeling after acute anterior wall myocardial infarction. ( 16423671 )
2006
50
Relationship between tissue reperfusion and postinfarction left ventricular remodelling in patients with anterior wall myocardial infarction treated with primary coronary angioplasty. ( 16699982 )
2006

Variations for Anterolateral Myocardial Infarction

Expression for Anterolateral Myocardial Infarction

Search GEO for disease gene expression data for Anterolateral Myocardial Infarction.

Pathways for Anterolateral Myocardial Infarction

Pathways related to Anterolateral Myocardial Infarction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.32 ACE PLAT
2 9.97 NPPA NPPB

GO Terms for Anterolateral Myocardial Infarction

Biological processes related to Anterolateral Myocardial Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to mechanical stimulus GO:0071260 9.37 IRF1 NPPA
2 regulation of blood vessel size GO:0050880 9.32 NPPA NPPB
3 regulation of blood vessel diameter GO:0097746 9.26 ACE NPPB
4 cGMP biosynthetic process GO:0006182 9.16 NPPA NPPB
5 receptor guanylyl cyclase signaling pathway GO:0007168 8.96 NPPA NPPB
6 regulation of blood pressure GO:0008217 8.8 ACE NPPA NPPB

Molecular functions related to Anterolateral Myocardial Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.13 NPPA NPPB PLAT
2 hormone receptor binding GO:0051427 8.62 NPPA NPPB

Sources for Anterolateral Myocardial Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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