Anthracosis

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CDC: ² The pneumoconioses are a group of interstitial lung diseases caused by the inhalation of certain dusts and the lung tissue's reaction to the dust. The principal cause of the pneumoconioses is work-place exposure; environmental exposures have rarely given rise to these diseases. The primary pneumoconioses are asbestosis, silicosis, and coal workers' pneumoconiosis (commonly referred to as CWP or black lung). As their names imply, they are caused by inhalation of asbestos fibers, silica dust, and coal mine dust. Typically, these three diseases take many years to develop and be manifested, although in some cases – silicosis, particularly – rapidly progressive forms can occur after only short periods of intense exposure. When severe, the diseases often lead to lung impairment, disability, and premature death. From a public health perspective, these conditions are entirely man-made, and can be avoided through appropriate dust control. Other forms of pneumoconioses can be caused by inhaling dusts containing aluminum, antimony, barium, graphite, iron, kaolin, mica, talc, among other dusts. There is also a form called mixed-dust pneumoconiosis. Overall, most physicians do not encounter these diseases very frequently. Byssinosis, caused by exposure to cotton dust, is sometimes included among the pneumoconioses, although its pattern of lung abnormality is different from the pneumoconioses listed here.

MalaCards based summary: Anthracosis, also known as black lung, is related to baritosis and bronchitis. An important gene associated with Anthracosis is CCL2 (C-C Motif Chemokine Ligand 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. The drugs Pirfenidone and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and heart, and related phenotype is Synthetic lethal with MLN4924 (a NAE inhibitor).

GARD: ¹⁹ A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population.

Disease Ontology: ¹¹ A pneumoconiosis that is characterized by deposition of carbon or coal dust in the lung parenchyma leading to the formation of black nodules and emphysema.

Wikipedia: ⁷⁵ Coal workers' pneumoconiosis (CWP), also known as black lung disease or black lung, is an occupational... more...

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