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MCID: ANT018
MIFTS: 45

Anthracosis

Categories: Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Anthracosis

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MalaCards integrated aliases for Anthracosis:

Name: Anthracosis 12 44 15 73
Coal Workers' Pneumoconiosis 12 76
Pneumoconiosis 53 73
Black Lung 12 3
Coal Worker's Pneumoconiosis 53
Coal Miner's Pneumoconiosis 12
Coal Workers Pneumoconiosis 55
Coal Workers' Lung 12
Black Lung Disease 53
Melanoedema 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:10327
ICD10 33 J60
ICD9CM 35 500
MeSH 44 D055008
NCIt 50 C34390
SNOMED-CT 68 155588007 29422001
UMLS 73 C0003165
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Summaries for Anthracosis

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CDC : 3 The pneumoconioses are a group of interstitial lung diseases caused by the inhalation of certain dusts and the lung tissue’s reaction to the dust. The principal cause of the pneumoconioses is work-place exposure; environmental exposures have rarely given rise to these diseases.

MalaCards based summary : Anthracosis, also known as coal workers' pneumoconiosis, is related to pneumoconiosis and silicosis. An important gene associated with Anthracosis is CCL2 (C-C Motif Chemokine Ligand 2), and among its related pathways/superpathways are PAK Pathway and Immune response IL-23 signaling pathway. The drugs Iron and Micronutrients have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and bone marrow.

Wikipedia : 76 Coal workers\' pneumoconiosis (CWP), also known as black lung disease or black lung, is caused by... more...

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Related Diseases for Anthracosis

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Diseases related to Anthracosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 pneumoconiosis 34.4 CCL2 TNF
2 silicosis 30.5 CCL2 TNF
3 kaolin pneumoconiosis 12.3
4 pneumoconiosis due to talc 12.2
5 graphite pneumoconiosis 12.1
6 interstitial lung disease 10.9
7 scleritis 10.5 CCL2 TNF
8 stachybotrys chartarum 10.5 CCL2 TNF
9 stromal keratitis 10.5 CCL2 TNF
10 pleural tuberculosis 10.5 CCL2 TNF
11 tuberculous meningitis 10.5 CCL2 TNF
12 dengue shock syndrome 10.5 CCL2 TNF
13 extrinsic cardiomyopathy 10.5 CCL2 TNF
14 viral encephalitis 10.5 CCL2 TNF
15 pleurisy 10.5 CCL2 TNF
16 complex regional pain syndrome 10.5 CCL2 TNF
17 chikungunya 10.5 CCL2 TNF
18 leptospirosis 10.5 CCL2 TNF
19 pyelonephritis 10.5 CCL2 TNF
20 neuritis 10.4 CCL2 TNF
21 severe acute respiratory syndrome 10.4 CCL2 TNF
22 chorioamnionitis 10.4 CCL2 TNF
23 pulmonary sarcoidosis 10.4 CCL2 TNF
24 alcoholic hepatitis 10.3 CCL2 TNF
25 autoinflammation, lipodystrophy, and dermatosis syndrome 10.3 CCL2 TNF
26 joint disorders 10.3 IL18R1 TNF
27 bone inflammation disease 10.3 CCL2 TNF
28 peritonitis 10.3 CCL2 TNF
29 respiratory system disease 10.3 CCL2 TNF
30 mediastinitis 10.2
31 overnutrition 10.2 CCL2 TNF
32 smallpox 10.2 IL18R1 TNF
33 urinary system disease 10.1 CCL2 TNF
34 esophagitis 10.1
35 pulmonary tuberculosis 10.1
36 lymphadenitis 10.0
37 adenocarcinoma 10.0
38 trypanosomiasis 10.0 CCL2 TNF
39 nontuberculous mycobacterial lung disease 10.0 BMP6 TNF
40 fasciitis 9.9 BMP6 TNF
41 rasmussen encephalitis 9.9 BMP6 TNF
42 arteries, anomalies of 9.9 CCL2 TNF
43 prostate cancer 9.9
44 lung cancer 9.9
45 prostatitis 9.9
46 dry eye syndrome 9.8 BMP6 TNF
47 small cell cancer of the lung 9.7
48 asthma 9.7
49 pulmonary hypertension 9.7
50 hepatitis 9.7

Comorbidity relations with Anthracosis via Phenotypic Disease Network (PDN): (show all 14)


Bronchitis Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Intermediate Coronary Syndrome Ischemic Heart Disease
Pneumoconiosis Postinflammatory Pulmonary Fibrosis
Prostate Cancer Prostatic Hypertrophy
Respiratory Failure Silicosis

Graphical network of the top 20 diseases related to Anthracosis:



Diseases related to Anthracosis
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Symptoms & Phenotypes for Anthracosis

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Drugs & Therapeutics for Anthracosis

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Drugs for Anthracosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4 7439-89-6 23925
2 Micronutrients Phase 4
3 Trace Elements Phase 4
4 Liver Extracts Phase 4
5
Amlodipine Approved Phase 2, Phase 3 88150-42-9 2162
6
Metoprolol Approved, Investigational Phase 2, Phase 3 37350-58-6, 51384-51-1 4171
7
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
8
Rifampicin Approved Phase 3 13292-46-1 5458213 5381226
9
Rifapentine Approved, Investigational Phase 3 61379-65-5 6323497
10 calcium channel blockers Phase 2, Phase 3
11 Adrenergic Agents Phase 2, Phase 3
12 Adrenergic Antagonists Phase 2, Phase 3
13 Adrenergic beta-1 Receptor Antagonists Phase 2, Phase 3
14 Adrenergic beta-Antagonists Phase 2, Phase 3
15 Sympatholytics Phase 2, Phase 3
16 Neurotransmitter Agents Phase 2, Phase 3
17 Anti-Arrhythmia Agents Phase 2, Phase 3
18 Vasodilator Agents Phase 2, Phase 3
19 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 1
20 Antihypertensive Agents Phase 2, Phase 3
21 Autonomic Agents Phase 2, Phase 3
22 Calcium, Dietary Phase 2, Phase 3
23 Vaccines Phase 3
24 Cytochrome P-450 CYP3A Inducers Phase 3
25 Nucleic Acid Synthesis Inhibitors Phase 3
26 Anti-Bacterial Agents Phase 3
27 Antibiotics, Antitubercular Phase 3
28 Hypolipidemic Agents Phase 3
29 Anti-Infective Agents Phase 3
30 Lipid Regulating Agents Phase 3
31 Antitubercular Agents Phase 3
32 Antimetabolites Phase 3
33
Infliximab Approved Phase 1, Phase 2 170277-31-3
34 Mesalamine Phase 1, Phase 2 89-57-6
35 Analgesics Phase 1, Phase 2
36 Mitogens Phase 1, Phase 2
37 Analgesics, Non-Narcotic Phase 1, Phase 2
38 Anti-Inflammatory Agents Phase 1, Phase 2
39 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
40 Antirheumatic Agents Phase 1, Phase 2,Phase 2
41 Gastrointestinal Agents Phase 1, Phase 2
42 Dermatologic Agents Phase 1, Phase 2
43
Deferiprone Approved 30652-11-0 2972
44
Heparin Approved, Investigational 9005-49-6 772 46507594
45 Respiratory System Agents
46 Chelating Agents
47 Iron Chelating Agents
48 calcium heparin
49 Pharmaceutical Solutions
50 Xenon Early Phase 1

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study) Completed NCT01736540 Phase 4
2 Effects of Metoprolol and Amlodipine on Cardiac Remodeling, Arrhythmias and Blood Pressure Variation in Hypertensive Patients With Sleep Apnea Syndrome Unknown status NCT02408172 Phase 2, Phase 3 Amlodipine;metoprolol
3 Trial to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine GSK2186877A in Adults 65 Year of Age and Older Completed NCT00753272 Phase 3
4 Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention Recruiting NCT02430259 Phase 3 Weekly INH / RRT given by DOT
5 Safety Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat Silicosis Completed NCT01977131 Phase 1, Phase 2
6 Targeting Oxidative Stress in Chronic Beryllium Disease Completed NCT01088243 Phase 1, Phase 2 Mesalamine;Placebo
7 Beryllium Infliximab Study: Clinical Interventional Trial Terminated NCT00111917 Phase 1, Phase 2 Infliximab
8 Human Umbilical Cord-Mesenchymal Stem Cells for Pneumoconiosis Unknown status NCT02790762 Phase 1
9 Safety of Stem Cells Intrabronchial Instillation for Silicosis Completed NCT01239862 Phase 1
10 A Study on Pneumoconiosis Treated With Whole-lung Lavage Combined With Mesenchymal Stem Cells Recruiting NCT02668068 Phase 1
11 Oscillation Mechanics of the Respiratory System Asbestos Exposed: Early Diagnosis Unknown status NCT02280343
12 Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01338064
13 DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01329003
14 Assessment of Iron Deposition in Major Organs of Hemodialysis Patients Unknown status NCT01169961
15 Comprehensive Risk Assessment of People With Silicosis: A Population-based Study Completed NCT02794701
16 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
17 Oscillation Mechanics of the Respiratory System in Never-smoking Patients With Silicosis Completed NCT01725971
18 Observational Study of Deferiprone (Ferriprox®) in the Treatment of Superficial Siderosis Completed NCT01284127
19 A Prospective Safety Follow Up Study Of Subjects Enrolled In Study A4321001 And Who Have Received Drug Product Completed NCT00471224
20 Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging Completed NCT02527330
21 Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and Sarcoidosis Completed NCT00560989
22 fMRI of the Brainstem in Migraine Sufferers and Controls. Does Iron Deposition Correlate With Progression of Disease? Completed NCT00868556
23 Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Disease (CBD) Recruiting NCT02604693
24 The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD) Recruiting NCT02596347
25 Superficial Siderosis in Patients With Suspected Cerebral Amyloid Angiopathy Active, not recruiting NCT01856699
26 Cortical Superficial Siderosis and Risk of Recurrent Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy. Not yet recruiting NCT03464344 Not Applicable
27 Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders Not yet recruiting NCT02748798 Early Phase 1 HP 3He;HP 129Xe;PFP;SF6

Search NIH Clinical Center for Anthracosis

Cochrane evidence based reviews: anthracosis

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Genetic Tests for Anthracosis

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Anatomical Context for Anthracosis

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MalaCards organs/tissues related to Anthracosis:

41
Lung, Lymph Node, Bone Marrow, Liver, Bone, Heart, Testes
Sources

Publications for Anthracosis

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Articles related to Anthracosis:

(show top 50) (show all 216)
# Title Authors Year
1
Estimated economic costs of coal workers' pneumoconiosis among coal workers redeployed from the Fuxin mining group in China. ( 29116190 )
2018
2
TNFR/TNF-I+ signaling pathway regulates apoptosis of alveolar macrophages in coal workers' pneumoconiosis. ( 29416696 )
2018
3
Association analysis identifies new risk loci for coal workers' pneumoconiosis in Han Chinese men. ( 29394417 )
2018
4
Prevalence of latent tuberculosis infection among coal workers' pneumoconiosis patients in China: a cross-sectional study. ( 29642880 )
2018
5
Black lungs and big nodes: A case of airway anthracosis with bronchial anthracofibrosis. ( 29892540 )
2018
6
Establishment and application of an index system for prevention of coal workers' pneumoconiosis: a Delphi and analytic hierarchy process study in four state-owned coal enterprises of China. ( 29563194 )
2018
7
Comment on Tomaskova et al. Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013. Int. J. Environ. Res. Public Health, 2017, 14, 269. ( 29415464 )
2018
8
A response to the Comment on Tomaskova et al. Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013. Int. J. Environ. Res. Public Health, 2017, 14, 269 by the Author Mei Yong. ( 29438277 )
2018
9
Continued increase in lung transplantation for coal workers' pneumoconiosis in the United States. ( 29732582 )
2018
10
A potential pitfall in the use of (68)Ga-PSMA PET/CT: Anthracosis. ( 27666999 )
2017
11
Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013. ( 28272360 )
2017
12
LRBA Gene Polymorphisms and Risk of Coal Workers' Pneumoconiosis: A Case-Control Study from China. ( 28953250 )
2017
13
The association of LAMB1 polymorphism and expression changes with the risk of coal workers' pneumoconiosis. ( 28444932 )
2017
14
Survival Analysis of Coal Workers' Pneumoconiosis (CWP) Patients in a State-Owned Mine in the East of China from 1963 to 2014. ( 28481235 )
2017
15
Polymorphisms in autophagy related genes and the coal workers' pneumoconiosis in a Chinese population. ( 28844669 )
2017
16
Anthracosis with a Mosaic Attenuation Pattern. ( 29279499 )
2017
17
Cross-section analysis of coal workers' pneumoconiosis and higher brachial-ankle pulse wave velocity within Kailuan study. ( 28148238 )
2017
18
Multi-Gene Expression in Anthracosis of the Lungs as One of the Risk Factors for Non-Small Cell Lung Cancer ( 29172290 )
2017
19
Diagnostic and clinical application value of magnetic resonance imaging (MRI) for progressive massive fibrosis of coal worker pneumoconiosis: Case reports. ( 28514304 )
2017
20
Pulmonary anthracosis mimicking lung metastases in pediatric rhabdomyosarcoma. ( 27592612 )
2016
21
Estimates and Predictions of Coal Workers' Pneumoconiosis Cases among Redeployed Coal Workers of the Fuxin Mining Industry Group in China: A Historical Cohort Study. ( 26845337 )
2016
22
Screening and Preliminary Verification of a Phage Display Single-Chain Antibody Library Against Coal Workers' Pneumoconiosis. ( 27930489 )
2016
23
Inguinal Lymph Node Anthracosis: A Case Report. ( 27536493 )
2016
24
Re: Anthracosis Mimicking Mediastinal Lymph Node Metastases With 18F-FCholine in High-Risk Prostate Cancer. ( 27749414 )
2016
25
Plasma LncRNA-ATB, a Potential Biomarker for Diagnosis of Patients with Coal Workers' Pneumoconiosis: A Case-Control Study. ( 27556453 )
2016
26
Pneumoconiosis Redux. Coal Workers' Pneumoconiosis and Silicosis Are Still a Problem. ( 26977968 )
2016
27
Coal workers' pneumoconiosis: an Australian perspective. ( 27318401 )
2016
28
Endobronchial anthracosis with concurrent primary lung cancer. ( 26917802 )
2016
29
Lung transplantation is increasingly common among patients with coal workers' pneumoconiosis. ( 26725917 )
2016
30
Platelet Indices in Patients with Coal Workers' Pneumoconiosis. ( 27107875 )
2016
31
Polymorphisms in Long Noncoding RNA H19 Contribute to the Protective Effects of Coal Workers' Pneumoconiosis in a Chinese Population. ( 27626436 )
2016
32
CT differentiation of enlarged mediastinal lymph node due to anthracosis from metastatic lymphadenopathy: a comparative study proven by endobronchial US-guided transbronchial needle aspiration. ( 25616268 )
2015
33
Clinico-radiological profile and risk factors in patients with anthracosis. ( 25814792 )
2015
34
Anthracosis: An unusual cause of vocal fold paralysis. ( 26214668 )
2015
35
Prevalence Characteristics of Coal Workers' Pneumoconiosis (CWP) in a State-Owned Mine in Eastern China. ( 26184259 )
2015
36
Associations of MMP-7 and OPN gene polymorphisms with risk of coal workers' pneumoconiosis in a Chinese population: a case-control study. ( 26330178 )
2015
37
Anthracosis mimicking mediastinal lymph node metastases with 18F-FCholine in high-risk prostate cancer. ( 25674859 )
2015
38
Comparison of the Cumulative Incidence Rates of Coal Workers' Pneumoconiosis between 1970 and 2013 among Four State-Owned Colliery Groups in China. ( 26133134 )
2015
39
A fire death with a rare finding: anthracosis or soot embolism? ( 25890616 )
2015
40
Polymorphisms in interleukin 17A gene and coal workers' pneumoconiosis risk in a Chinese population. ( 26223249 )
2015
41
Serum levels of IL-8 and ICAM-1 as biomarkers for progressive massive fibrosis in coal workers' pneumoconiosis. ( 25653483 )
2015
42
Risk factors and maximum standardized uptake values within lymph nodes of anthracosis diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration. ( 26422878 )
2015
43
Percutaneous treatment for pulmonary hypertension caused by pulmonary artery stenosis due to anthracosis. ( 25946371 )
2015
44
Associations of MMP1, MMP2 and MMP3 Genes Polymorphism with Coal Workers' Pneumoconiosis in Chinese Han Population. ( 26528997 )
2015
45
Comparison of samples obtained from bronchoscopy of patients with and without bronchial anthracosis for investigating the prevalence of Mycobacterium tuberculosis. ( 26405675 )
2015
46
Cost-Effectiveness of Coal Workers' Pneumoconiosis Prevention Based on Its Predicted Incidence within the Datong Coal Mine Group in China. ( 26098706 )
2015
47
Chest CT Findings in EBUS-TBNA-Proven Anthracosis inA Enlarged Mediastinal Lymph Nodes. ( 24955645 )
2014
48
Value of the polymerase chain reaction method for detecting tuberculosis in the bronchial tissue involved by anthracosis. ( 24739686 )
2014
49
Serum levels of TGF-I^1 and MCP-1 as biomarkers for progressive coal workers' pneumoconiosis in retired coal workers: a three-year follow-up study. ( 24464026 )
2014
50
Polymorphisms in SPARC and coal workers' pneumoconiosis risk in a Chinese population. ( 25126876 )
2014
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Variations for Anthracosis

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Expression for Anthracosis

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Search GEO for disease gene expression data for Anthracosis.
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Pathways for Anthracosis

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Pathways related to Anthracosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
PAK Pathway 64
Show member pathways
 12.82 BMP6 CCL2 IL18R1 TNF
2
Immune response IL-23 signaling pathway 22
Show member pathways
 12.08 CCL2 IL18R1 TNF
3
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.62 BMP6 CCL2 IL18R1
4
Lung fibrosis 1
11.2 CCL2 TNF
5
Interleukin-10 signaling 66
11.01 CCL2 TNF
6
Malaria 37
10.95 CCL2 TNF
7
MSP-RON Signaling 64
10.84 CCL2 TNF
8
TNF signaling pathway 37
10.83 CCL2 IL18R1 TNF
9
LDL Oxidation in Atherogenesis 64
10.16 CCL2 TNF
Sources

GO Terms for Anthracosis

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Biological processes related to Anthracosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.65 BMP6 CCL2 TNF
2 cellular response to organic cyclic compound GO:0071407 9.49 CCL2 TNF
3 response to glucocorticoid GO:0051384 9.46 BMP6 TNF
4 positive regulation of epithelial cell proliferation GO:0050679 9.43 BMP6 LAMB1
5 humoral immune response GO:0006959 9.4 CCL2 TNF
6 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.37 IL18R1 TNF
7 protein kinase B signaling GO:0043491 9.32 CCL2 TNF
8 positive regulation of interferon-gamma production GO:0032729 9.26 IL18R1 TNF
9 negative regulation of viral genome replication GO:0045071 9.16 BANF1 TNF
10 lipopolysaccharide-mediated signaling pathway GO:0031663 8.96 CCL2 TNF
11 immune response GO:0006955 8.92 BMP6 CCL2 IL18R1 TNF

Molecular functions related to Anthracosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 BMP6 CCL2 TNF
Sources

Sources for Anthracosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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