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MCID: ANT018
MIFTS: 48

Anthracosis

Categories: Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Anthracosis

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MalaCards integrated aliases for Anthracosis:

Name: Anthracosis 12 43 15 17 71
Coal Workers' Pneumoconiosis 12 74
Pneumoconiosis 52 71
Black Lung 12 3
Coal Worker's Pneumoconiosis 52
Coal Miner's Pneumoconiosis 12
Coal Workers Pneumoconiosis 54
Coal Workers' Lung 12
Black Lung Disease 52
Melanoedema 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:10327
ICD9CM 34 500
MeSH 43 D055008
NCIt 49 C34390
SNOMED-CT 67 29422001
ICD10 32 J60
UMLS 71 C0003165 C0032273
Sources

Summaries for Anthracosis

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CDC : 3 The pneumoconioses are a group of interstitial lung diseases caused by the inhalation of certain dusts and the lung tissue's reaction to the dust. The principal cause of the pneumoconioses is work-place exposure; environmental exposures have rarely given rise to these diseases. The primary pneumoconioses are asbestosis, silicosis, and coal workers' pneumoconiosis (commonly referred to as CWP or black lung). As their names imply, they are caused by inhalation of asbestos fibers, silica dust, and coal mine dust. Typically, these three diseases take many years to develop and be manifested, although in some cases – silicosis, particularly – rapidly progressive forms can occur after only short periods of intense exposure. When severe, the diseases often lead to lung impairment, disability, and premature death. From a public health perspective, these conditions are entirely man-made, and can be avoided through appropriate dust control. Other forms of pneumoconioses can be caused by inhaling dusts containing aluminum, antimony, barium, graphite, iron, kaolin, mica, talc, among other dusts. There is also a form called mixed-dust pneumoconiosis. Overall, most physicians do not encounter these diseases very frequently. Byssinosis, caused by exposure to cotton dust, is sometimes included among the pneumoconioses, although its pattern of lung abnormality is different from the pneumoconioses listed here.

MalaCards based summary : Anthracosis, also known as coal workers' pneumoconiosis, is related to bronchitis and pulmonary tuberculosis. An important gene associated with Anthracosis is CCL2 (C-C Motif Chemokine Ligand 2), and among its related pathways/superpathways are NOD-like receptor signaling pathway and Osteoclast differentiation. The drugs Amlodipine and Metoprolol have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and lymph node.

Wikipedia : 74 Coal workers' pneumoconiosis (CWP), also known as black lung disease or black lung, is caused by... more...

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Related Diseases for Anthracosis

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Diseases related to Anthracosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 290)
# Related Disease Score Top Affiliating Genes
1 bronchitis 30.9 TNF IL1B EPHX1
2 pulmonary tuberculosis 30.9 TNF IL1B CCL2
3 pneumoconiosis 30.6 TNF TGFB1 IL1B CCL2
4 silicosis 30.5 TNF TGFB1 IL1B CCL2
5 pleurisy 30.3 TNF TGFB1 CCL2
6 lung disease 30.2 TNF TGFB1 IL1B CCL2
7 bronchial disease 30.1 TNF IL1B CCL2
8 pulmonary fibrosis, idiopathic 30.1 TNF TGFB1 IL1B CCL2
9 sleep apnea 29.9 TNF IL1B CCL2
10 arteries, anomalies of 29.9 TNF MIR18A IL1B CCL2
11 gout 29.9 TNF IL1B CCL2
12 interstitial lung disease 29.8 TNF TGFB1 IL1B CCL2
13 esophagitis 29.8 TNF TGFB1 IL1B
14 pulmonary disease, chronic obstructive 29.2 TNF TGFB1 IL1B EPHX1 CCL2
15 kaolin pneumoconiosis 12.7
16 pneumoconiosis due to talc 12.6
17 graphite pneumoconiosis 12.4
18 mixed mineral dust pneumoconiosis 12.2
19 slate pneumoconiosis 12.2
20 labrador lung 12.2
21 caplan's syndrome 12.1
22 aluminosis 12.1
23 silicosiderosis 11.9
24 baritosis 11.7
25 berylliosis 11.7
26 beryllium disease 11.2
27 nontuberculous mycobacterial lung disease 11.2
28 respiratory failure 10.5
29 autoimmune myocarditis 10.5 TNF CCL2
30 fibrosis of extraocular muscles, congenital, 1 10.4
31 pneumothorax 10.4
32 aspergillosis 10.4
33 heart disease 10.4
34 benign mesothelioma 10.4
35 lymphadenitis 10.4
36 physiological polycythemia 10.3 TNF IL1B
37 pneumonia 10.3
38 systemic onset juvenile idiopathic arthritis 10.3 TNF IL1B
39 adenocarcinoma 10.3
40 staphylococcal toxic shock syndrome 10.3 TNF IL1B
41 byssinosis 10.3
42 vulvar vestibulitis syndrome 10.3 TNF IL1B
43 kashin-beck disease 10.3 TNF IL1B
44 posterior urethral valves 10.3 TNF TGFB1
45 pneumothorax, primary spontaneous 10.3
46 arthritis 10.3
47 anaerobic pneumonia 10.2 TNF IL1B
48 jejunoileitis 10.2 TNF IL1B
49 asbestosis 10.2
50 siderosis 10.2

Comorbidity relations with Anthracosis via Phenotypic Disease Network (PDN): (show all 12)


Bronchitis Chronic Pulmonary Heart Disease
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Intermediate Coronary Syndrome
Pneumoconiosis Postinflammatory Pulmonary Fibrosis
Prostate Cancer Prostatic Hypertrophy
Respiratory Failure Silicosis

Graphical network of the top 20 diseases related to Anthracosis:



Diseases related to Anthracosis
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Symptoms & Phenotypes for Anthracosis

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Drugs & Therapeutics for Anthracosis

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Drugs for Anthracosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amlodipine Approved Phase 2, Phase 3 88150-42-9 2162
2
Metoprolol Approved, Investigational Phase 2, Phase 3 37350-58-6, 51384-51-1 4171
3 Adrenergic beta-1 Receptor Antagonists Phase 2, Phase 3
4 Antihypertensive Agents Phase 2, Phase 3
5 Hormones Phase 2, Phase 3
6 Adrenergic Agents Phase 2, Phase 3
7 Adrenergic Antagonists Phase 2, Phase 3
8 Anti-Arrhythmia Agents Phase 2, Phase 3
9 Vasodilator Agents Phase 2, Phase 3
10 Adrenergic beta-Antagonists Phase 2, Phase 3
11 Sympatholytics Phase 2, Phase 3
12 Calcium, Dietary Phase 2, Phase 3
13 Neurotransmitter Agents Phase 2, Phase 3
14 calcium channel blockers Phase 2, Phase 3
15
Calcium Nutraceutical Phase 2, Phase 3 7440-70-2 271
16
Nintedanib Approved Phase 2 656247-17-5 56843413
17
Cocaine Approved, Illicit 50-36-2 446220 5760
18 Kava Approved, Investigational, Nutraceutical 9000-38-8

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 The Study Was Approved by the Ethics Committee of Our Institution, Which is Accredited by the Office of Human Research Protection as an Institutional Review Board Unknown status NCT02408172 Phase 2, Phase 3 Amlodipine;metoprolol
2 The Nintedanib in Progressive Pneumoconiosis Study (NiPPS): a Collaborative NSW Treatment Trial Not yet recruiting NCT04161014 Phase 2 Nintedanib 150 MG [Ofev]
3 A Phase I Study of Human Umbilical Cord-Mesenchymal Stem Cells for Pneumoconiosis Unknown status NCT02790762 Phase 1
4 A Multicenter, Randomized, Single-blind, Parallel-group Study of Combined Large Volume WLL With Clinical Grade Umbilical Cord Mesenchymal Stem Cells(MSC) Transplantation for Treatment of Pneumoconiosis Completed NCT02668068 Phase 1
5 Definition of the Status of the Human Lung Stem Cell Niches ex Vivo in Tissue Biopsies Performed in Patients With Emphysema and Interstitial Fibrosis Compared to Non-diseased Areas Unknown status NCT02705144
6 Usefulness of Integrated PET/MRI in Oropharyngeal Squamous Cell Carcinoma Evaluation Unknown status NCT03163797
7 Comprehensive Risk Assessment of People With Silicosis: A Population-based Study Completed NCT02794701
8 Lung Ultrasound as an Evolving Tool in Detection of Extravascular Lung Water in Septic Cancer Patients. Completed NCT03676699
9 Palliative Care Coaching for Family Caregivers & Patients With Rare Advanced Lung Disease Completed NCT03813667
10 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
11 The Experience of Patients and Family Caregivers in Managing Pneumoconiosis in the Family Context: An Exploratory Qualitative Study Recruiting NCT04022902
12 Screening Strategy for Early Diagnosis of Silicosis in At-Risk Populations in Oklahoma Recruiting NCT04205708
13 DNA Methylation Analysis to Identify Functional Epigenetic Marks in Acute Coronary Syndrome and Atrial Fibrillation Recruiting NCT04371809

Search NIH Clinical Center for Anthracosis

Cochrane evidence based reviews: anthracosis

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Genetic Tests for Anthracosis

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Anatomical Context for Anthracosis

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MalaCards organs/tissues related to Anthracosis:

40
Lung, Testes, Lymph Node, Heart, Liver, Neutrophil, Bone
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Publications for Anthracosis

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Articles related to Anthracosis:

(show top 50) (show all 4366)
# Title Authors PMID Year
1
[Transforming growth factor beta and tumor necrosis factor gene polymorphism and coal worker's pneumoconiosis]. 61 54
19493496 2009
2
Polymorphisms in chemokine and chemokine receptor genes and the development of coal workers' pneumoconiosis. 61 54
16524739 2006
3
[Oxidative injury and serum cytokines in coal workers with pneumoconiosis]. 54 61
16078574 2005
4
MCP-1 secretion in lung from nonsmoking patients with coal worker's pneumoconiosis. 61 54
9072984 1997
5
The role of cytokines in human lung fibrosis. 54 61
8680382 1996
6
Mechanisms of fibrosis in coal workers' pneumoconiosis. Increased production of platelet-derived growth factor, insulin-like growth factor type I, and transforming growth factor beta and relationship to disease severity. 61 54
7921435 1994
7
Magnetic targeting increases mesenchymal stromal cell retention in lungs and enhances beneficial effects on pulmonary damage in experimental silicosis. 61
32538526 2020
8
[Level and trend of respiratory diseases mortality in China from 2002 to 2016]. 61
32575935 2020
9
Peripheral type squamous cell carcinoma of the lung: clinicopathologic characteristics in comparison to the central type. 61
32544984 2020
10
Prevalence and attributable health burden of chronic respiratory diseases, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. 61
32526187 2020
11
Trends in Pneumoconiosis Deaths - United States, 1999-2018. 61
32525855 2020
12
Eye Tracking to Evaluate the Usability of an Online Pneumoconiosis Education Booklet in a Sample of South Asian Construction Workers. 61
32541364 2020
13
Estimating the prevalence and spatial clusters of coal workers' pneumoconiosis cases using medicare claims data, 2011-2014. 61
32147857 2020
14
Pneumoconiosis progression patterns in US coal miner participants of a job transfer programme designed to prevent progression of disease. 61
32169972 2020
15
Trends in global, regional and national incidence of pneumoconiosis caused by different aetiologies: an analysis from the Global Burden of Disease Study 2017. 61
32188634 2020
16
The utility of elastography during EBUS-TBNA in a population with a high prevalence of anthracosis. 61
32034995 2020
17
A Case of Nodal Anthracosis Presenting as PET-Positive Mediastinal and Hilar Lymphadenopathies. 61
32370837 2020
18
[Study on clinical phenotype of coal workers pneumoconiosis]. 61
32536078 2020
19
Increased risk of gastric cancer in workers with occupational dust exposure. 61
32375207 2020
20
Potential of deep learning in assessing pneumoconiosis depicted on digital chest radiography. 61
32471837 2020
21
A new era of coal workers' pneumoconiosis: decades in mines may not be required. 61
32359461 2020
22
Comparison of Risk of Silicosis in Metal Mines and Pottery Factories: A 44-Year Cohort Study. 61
32298729 2020
23
Silicosis in finishing workers in quartz conglomerates processing. 61
32352423 2020
24
[Serum metabolomics in latent pneumoconiosis tuberculosis patients based on ultra performance liquid chromatography tandem quadrupole time of flight mass spectrometry]. 61
32447884 2020
25
[Analysis of the burden of coal worker's pneumoconiosis disease in a mining group]. 61
32447893 2020
26
What does coal mine dust lung disease look like? A radiological review following re-identification in Queensland. 61
32048474 2020
27
Association of Silica Dust Exposure and Cigarette Smoking With Mortality Among Mine and Pottery Workers in China. 61
32286660 2020
28
Self-management of oxygen and bronchodilators to relieve the dyspnoea of lung cancer with pneumoconiosis. 61
32378485 2020
29
[Follow-up and retrospective investigation of patients with pneumoconiosis in Jiangsu Province, China]. 61
32447885 2020
30
Prevalence of spirometry-defined airflow obstruction in never-smoking working US coal miners by pneumoconiosis status. 61
32041810 2020
31
NAF1 rs4691896 Is Significantly Associated with Coal Workers' Pneumoconiosis in a Chinese Han Population: A Case-Control Study. 61
32333749 2020
32
[Progress in study on intervention of silica-induced pulmonary fibrosis with the exosomes released from mesenchymal stem cells]. 61
32447901 2020
33
Respiratory surveillance in mineral dust-exposed workers. 61
32194772 2020
34
[Diagnostic value of heparin-binding protein in patients with silicosis complicated by severe infection]. 61
32306695 2020
35
Global and regional burden of chronic respiratory disease in 2016 arising from non-infectious airborne occupational exposures: a systematic analysis for the Global Burden of Disease Study 2016. 61
32054818 2020
36
Assessment of silica dust exposure profile in relation to prevalence of silicosis among Indian sandstone mine workers: Need for review of standards. 61
31773774 2020
37
[Systems and actual practices of occupational safety and health risk management in the People's Republic of China]. 61
31474689 2020
38
[Diagnostic Challenges of Mixed Dust Silicosis (Mixed Dust Pneumoconiosis) - 5 Case Reports]. 61
32052391 2020
39
Intra-pleural Instillation of Autologous Blood - Fine-tuning Techniques for Better Success Rate: Two Case Reports. 61
32281606 2020
40
Autophagy, an important therapeutic target for pulmonary fibrosis diseases. 61
31877297 2020
41
Editorial: Timely topical reviews on climate change, indoor air pollution, coalworkers' pneumoconiosis, and chronic obstructive pulmonary disease. 61
31904625 2020
42
[Analysis of other diseases misdiagnosed as pneumoconiosis]. 61
32306696 2020
43
Spatial and Temporal Variations of Pneumoconiosis in the Pearl River Delta Region in 2006-2015. 61
32209178 2020
44
[Meta-analysis on association between interleukin-6-174C/G and -634C/G polymorphisms and pneumoconiosis susceptibility]. 61
32290930 2020
45
Associations of HMGB1 gene polymorphisms with risk of coal workers' pneumoconiosis susceptibility in Chinese Han population. 61
32408780 2020
46
Pneumoconiosis ICD-CM Diagnosis Codes on Medicare Claims for Federal Black Lung Program Beneficiaries. 61
32182100 2020
47
[The characteristics of spatial-temporal evolvement of pneumoconiosis in Hebei Province from 2009 to 2018]. 61
32306689 2020
48
Respirable coal mine dust at surface mines, United States, 1982-2017. 61
31820465 2020
49
Coal mining and lung disease in the 21st century. 61
31815751 2020
50
[Analysis on the situation of being supported by the national natural science foundation of China in the field of occupational diseases from 2010 to 2019]. 61
32306676 2020
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Variations for Anthracosis

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Expression for Anthracosis

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Search GEO for disease gene expression data for Anthracosis.
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Pathways for Anthracosis

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Pathways related to Anthracosis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
NOD-like receptor signaling pathway 36
12.07 TNF IL1B CCL2 CARD8
2
Osteoclast differentiation 36
11.87 TNF TGFB1 IL1B
3
Yersinia infection 36
11.84 TNF IL1B CCL2
4
Spinal Cord Injury 1
11.81 TNF TGFB1 IL1B CCL2
5
TNF signaling pathway 36
11.8 TNF IL1B CCL2
6
IL27-mediated signaling events 1
Show member pathways
 11.77 TNF TGFB1 IL1B
7
Amoebiasis 36
11.73 TNF TGFB1 IL1B
8
Interleukin-4 and 13 signaling 65
11.73 TNF TGFB1 IL1B CCL2
9
AGE-RAGE signaling pathway in diabetic complications 36
11.62 TNF TGFB1 IL1B CCL2
10
Dendritic Cells Developmental Lineage Pathway 64
11.57 TNF TGFB1 IL1B
11
Rheumatoid arthritis 36
11.53 TNF TGFB1 IL1B CCL2
12
Interleukin-10 signaling 65
11.36 TNF IL1B CCL2
13
MSP-RON Signaling 63
11.33 TNF IL1B CCL2
14
Aryl Hydrocarbon Receptor Pathway 1
11.31 TNF TGFB1 IL1B
15
Lung fibrosis 1
11.06 TNF TGFB1 IL1B CCL2
16
Cytokines and Inflammatory Response 1
11.04 TNF TGFB1 IL1B
17
RXR and RAR heterodimerization with other nuclear receptor 1
10.7 TNF TGFB1
18
IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types 64
10.62 TGFB1 IL1B
19
Malaria 36
10.62 TNF TGFB1 IL1B CCL2
20
LDL Oxidation in Atherogenesis 63
10.54 TNF IL1B CCL2
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GO Terms for Anthracosis

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Biological processes related to Anthracosis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.83 TNF TGFB1 IL1B CCL2
2 MAPK cascade GO:0000165 9.8 TNF TGFB1 IL1B CCL2
3 positive regulation of glial cell proliferation GO:0060252 9.59 TNF IL1B
4 negative regulation of lipid catabolic process GO:0050995 9.58 TNF IL1B
5 astrocyte activation GO:0048143 9.58 TNF IL1B
6 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.57 TNF IL1B
7 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.56 TNF IL1B
8 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.55 TNF IL1B
9 positive regulation of chemokine biosynthetic process GO:0045080 9.54 TNF IL1B
10 positive regulation of neuroinflammatory response GO:0150078 9.51 TNF IL1B
11 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.48 TNF TGFB1
12 regulation of establishment of endothelial barrier GO:1903140 9.46 TNF IL1B
13 cellular response to organic cyclic compound GO:0071407 9.46 TNF TGFB1 IL1B CCL2
14 positive regulation of mononuclear cell migration GO:0071677 9.43 TNF TGFB1
15 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.43 TNF IL1B CARD8
16 positive regulation of fever generation GO:0031622 9.4 TNF IL1B
17 sequestering of triglyceride GO:0030730 9.37 TNF IL1B
18 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 TNF IL1B
19 protein kinase B signaling GO:0043491 9.26 TNF TGFB1 IL1B CCL2
20 lipopolysaccharide-mediated signaling pathway GO:0031663 8.92 TNF TGFB1 IL1B CCL2

Molecular functions related to Anthracosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 TNF TGFB1 IL1B CCL2
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Sources for Anthracosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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