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MCID: ANT018
MIFTS: 51

Anthracosis

Categories: Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Anthracosis

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MalaCards integrated aliases for Anthracosis:

Name: Anthracosis 12 44 15 17 71
Coal Workers' Pneumoconiosis 12 74
Pneumoconiosis 20 71
Black Lung 12 3
Coal Worker's Pneumoconiosis 20
Coal Miner's Pneumoconiosis 12
Coal Workers Pneumoconiosis 54
Coal Workers' Lung 12
Black Lung Disease 20
Melanoedema 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:10327
ICD9CM 34 500
MeSH 44 D055008
NCIt 50 C34390
SNOMED-CT 67 29422001
ICD10 32 J60
UMLS 71 C0003165 C0032273
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Summaries for Anthracosis

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CDC : 3 The pneumoconioses are a group of interstitial lung diseases caused by the inhalation of certain dusts and the lung tissue's reaction to the dust. The principal cause of the pneumoconioses is work-place exposure; environmental exposures have rarely given rise to these diseases. The primary pneumoconioses are asbestosis, silicosis, and coal workers' pneumoconiosis (commonly referred to as CWP or black lung). As their names imply, they are caused by inhalation of asbestos fibers, silica dust, and coal mine dust. Typically, these three diseases take many years to develop and be manifested, although in some cases – silicosis, particularly – rapidly progressive forms can occur after only short periods of intense exposure. When severe, the diseases often lead to lung impairment, disability, and premature death. From a public health perspective, these conditions are entirely man-made, and can be avoided through appropriate dust control. Other forms of pneumoconioses can be caused by inhaling dusts containing aluminum, antimony, barium, graphite, iron, kaolin, mica, talc, among other dusts. There is also a form called mixed-dust pneumoconiosis. Overall, most physicians do not encounter these diseases very frequently. Byssinosis, caused by exposure to cotton dust, is sometimes included among the pneumoconioses, although its pattern of lung abnormality is different from the pneumoconioses listed here.

MalaCards based summary : Anthracosis, also known as coal workers' pneumoconiosis, is related to beryllium disease and baritosis. An important gene associated with Anthracosis is CCL2 (C-C Motif Chemokine Ligand 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. The drugs Pirfenidone and Nintedanib have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and heart, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Coal workers' pneumoconiosis (CWP), also known as black lung disease or black lung, is caused by... more...

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Related Diseases for Anthracosis

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Diseases related to Anthracosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 629)
# Related Disease Score Top Affiliating Genes
1 beryllium disease 31.8 TNF TGFB1
2 baritosis 31.6 IL1B CXCL8
3 chronic beryllium disease 30.6 TNF TGFB1
4 pulmonary tuberculosis 30.6 TNF IL6 CCL2
5 bronchitis 30.3 TNF IL6 IL1B EPHX1 CXCL8
6 lymphadenitis 30.0 TNF IL1B CXCL8
7 haemophilus influenzae 29.9 TNF CXCL8
8 aspergillosis 29.8 TNF IL6 IL1B CXCL8
9 pulmonary alveolar proteinosis 29.7 TNF IL6 CXCL8 CCL2
10 extrinsic allergic alveolitis 29.6 IL6 IL1B CXCL8 CCL2
11 sarcoidosis 1 29.6 TNF SCGB1A1 IL1B CCL2
12 peptic ulcer disease 29.6 TNF IL1B CXCL8
13 pleurisy 29.6 TNF TGFB1 CXCL8 CCL2
14 pleural tuberculosis 29.5 TNF CXCL8 CCL2
15 respiratory failure 29.4 TNF SCGB1A1 IL6 IL1B CXCL8 CCL2
16 pleural disease 29.4 TNF IL6 IL1B CXCL8
17 silicosis 29.4 TNF TGFB1 SCGB1A1 IL1B CXCL8 CCL2
18 endocarditis 29.4 TNF IL6 CXCL8
19 pulmonary fibrosis 29.4 TGFB1 IL1B CXCL8 CCL2
20 pulmonary edema 29.2 TNF SCGB1A1 IL1B CXCL8
21 pneumoconiosis 29.2 TNF TGFB1 SCGB1A1 IL6 IL1B CXCL8
22 bronchiectasis 29.2 TNF IL6 IL1B CXCL8
23 pneumonia 29.2 TNF SCGB1A1 IL6 IL1B CXCL8 CCL2
24 paranasal sinus disease 29.1 TNF TGFB1 IL6 CXCL8
25 bronchiolitis 29.1 TNF IL6 IL1B CXCL8 CCL2
26 esophagitis 29.1 TNF IL6 IL1B CXCL8
27 bronchopneumonia 29.1 TNF IL6 IL1B CXCL8
28 pericarditis 29.1 TNF IL6 IL1B CXCL8
29 tonsillitis 29.1 TNF IL6 IL1B CXCL8
30 rhinitis 29.1 TNF SCGB1A1 IL6 CXCL8
31 gout 29.1 TNF IL6 IL1B CXCL8
32 bronchial disease 29.1 TNF IL6 IL1B CXCL8 CCL2
33 lipoprotein quantitative trait locus 29.0 TNF IL6 IL1B CXCL8 CCL2
34 severe acute respiratory syndrome 28.9 TNF IL6 IL1B CXCL8 CCL2
35 bacterial infectious disease 28.9 TNF IL6 IL1B CXCL8 CCL2
36 pulmonary fibrosis, idiopathic 28.9 TNF TGFB1 SCGB1A1 IL6 IL1B CXCL8
37 interstitial lung disease 28.8 TNF TGFB1 IL6 IL1B CXCL8 CCL2
38 pulmonary hypertension 28.8 TNF TGFB1 IL6 IL1B CXCL8 CCL2
39 lung disease 28.7 TNF TGFB1 SCGB1A1 IL6 IL1B CXCL8
40 bronchiolitis obliterans 28.7 TNF TGFB1 SCGB1A1 IL6 CXCL8
41 autoimmune disease 28.7 TNF TGFB1 IL6 IL1B CXCL8 CCL2
42 connective tissue disease 28.6 TNF MIR18A IL6 IL1B CXCL8 CCL2
43 osteoporosis 28.6 TNF TGFB1 IL6 IL1B CXCL8 CCL2
44 malaria 28.6 TNF TGFB1 IL6 IL1B CXCL8 CCL2
45 rheumatoid arthritis 28.4 TNF TGFB1 IL6 IL1B CXCL8 CCL2
46 pulmonary disease, chronic obstructive 28.1 TNF TGFB1 SCGB1A1 IL6 IL1B EPHX1
47 kaolin pneumoconiosis 11.5
48 labrador lung 11.4
49 caplan's syndrome 11.4
50 silicosiderosis 11.3

Comorbidity relations with Anthracosis via Phenotypic Disease Network (PDN): (show all 12)


Bronchitis Chronic Pulmonary Heart Disease
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Intermediate Coronary Syndrome
Pneumoconiosis Postinflammatory Pulmonary Fibrosis
Prostate Cancer Prostatic Hypertrophy
Respiratory Failure Silicosis

Graphical network of the top 20 diseases related to Anthracosis:



Diseases related to Anthracosis
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Symptoms & Phenotypes for Anthracosis

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GenomeRNAi Phenotypes related to Anthracosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.36 CARD8 CXCL8 IL1B TGFB1 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.36 CARD8 CXCL8 IL1B TGFB1 TMEM268 TNF

MGI Mouse Phenotypes related to Anthracosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.1 EPHX1 IL1B IL6 SCGB1A1 TGFB1 TNF
Sources

Drugs & Therapeutics for Anthracosis

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Drugs for Anthracosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pirfenidone Approved, Investigational Phase 2 53179-13-8 40632
2
Nintedanib Approved Phase 2 656247-17-5 56843413
3 Anti-Inflammatory Agents Phase 2
4 Analgesics, Non-Narcotic Phase 2
5 Anti-Inflammatory Agents, Non-Steroidal Phase 2
6 Analgesics Phase 2
7 Antirheumatic Agents Phase 2
8
Cocaine Approved, Illicit 50-36-2 5760 446220

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Examination of Pirfenidone (Esbriet®) Therapy in Coal Workers' Pneumoconiosis With Pulmonary Fibrosis Associated With Radiographic and Functional Impairment to Examine the Reduction in Progression of Disease, Reduction of Exacerbation Rates and Possible Reduction of Inflammatory Biomarkers as an Index of Clinical Response. Recruiting NCT04461587 Phase 2 Pirfenidone
2 The Nintedanib in Progressive Pneumoconiosis Study (NiPPS): a Collaborative NSW Treatment Trial Recruiting NCT04161014 Phase 2 Nintedanib 150 MG [Ofev]
3 A Phase I Study of Human Umbilical Cord-Mesenchymal Stem Cells for Pneumoconiosis Unknown status NCT02790762 Phase 1
4 A Multicenter, Randomized, Single-blind, Parallel-group Study of Combined Large Volume WLL With Clinical Grade Umbilical Cord Mesenchymal Stem Cells(MSC) Transplantation for Treatment of Pneumoconiosis Completed NCT02668068 Phase 1
5 The Experience of Patients and Family Caregivers in Managing Pneumoconiosis in the Family Context: An Exploratory Qualitative Study Completed NCT04022902
6 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
7 Screening Strategy for Early Diagnosis of Silicosis in At-Risk Populations in Oklahoma Recruiting NCT04205708

Search NIH Clinical Center for Anthracosis

Cochrane evidence based reviews: anthracosis

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Genetic Tests for Anthracosis

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Anatomical Context for Anthracosis

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MalaCards organs/tissues related to Anthracosis:

40
Lung, Lymph Node, Heart, Skin, Eye, Thyroid, Monocytes
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Publications for Anthracosis

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Articles related to Anthracosis:

(show top 50) (show all 4469)
# Title Authors PMID Year
1
[Transforming growth factor beta and tumor necrosis factor gene polymorphism and coal worker's pneumoconiosis]. 61 54
19493496 2009
2
Polymorphisms in chemokine and chemokine receptor genes and the development of coal workers' pneumoconiosis. 54 61
16524739 2006
3
[Oxidative injury and serum cytokines in coal workers with pneumoconiosis]. 61 54
16078574 2005
4
MCP-1 secretion in lung from nonsmoking patients with coal worker's pneumoconiosis. 61 54
9072984 1997
5
The role of cytokines in human lung fibrosis. 54 61
8680382 1996
6
Mechanisms of fibrosis in coal workers' pneumoconiosis. Increased production of platelet-derived growth factor, insulin-like growth factor type I, and transforming growth factor beta and relationship to disease severity. 54 61
7921435 1994
7
Mortality from silicosis in Brazil: Temporal trends in the period 1980-2017. 61
33410169 2021
8
Respiratory traits and coal workers' pneumoconiosis: Mendelian randomisation and association analysis. 61
33097673 2021
9
Macrophage autophagy protects mice from cerium oxide nanoparticle-induced lung fibrosis. 61
33526046 2021
10
Development of a multimedia intervention to improve pneumoconiosis prevention in construction workers using RE-AIM framework. 61
33576371 2021
11
Automated detection of pneumoconiosis with multilevel deep features learned from chest X-Ray radiographs. 61
33310394 2021
12
Characterizing patterns of small pneumoconiotic opacities on chest radiographs of New Mexico coal miners. 61
33583358 2021
13
Scary black nodes. 61
33555660 2021
14
A Nurse-Led Education Program for Pneumoconiosis Caregivers at the Community Level. 61
33530598 2021
15
A deep learning-based model for screening and staging pneumoconiosis. 61
33500426 2021
16
Omics Approaches for Exploring Pneumoconiosis: A Review. 61
33531110 2021
17
Analysis of Health Service Utilization and its Influencing Factors among Patients with Pneumoconiosis in China. 61
33531111 2021
18
Alteration of thiol disulfide homeostasis and ischemia-modified albumin levels as indicators of oxidative status in patients with silicosis. 61
33305688 2021
19
The relationship between respiratory health and hard metal dust exposure: A cross-sectional study. 61
33432872 2021
20
Changes in Health-Related Quality of Life During the First Year in Lung Transplant Recipients. 61
32768289 2021
21
Single intratracheal administration of cross-linked water-soluble acrylic acid polymer causes acute alveolo-interstitial inflammation and the subsequent fibrotic formation possibly via the TGF-β1 pathway in the lung of rats. 61
33259820 2021
22
Sex-Related Differences in the Risk of Silicosis Among Chinese Pottery Workers: A Cohort Study. 61
33122539 2021
23
Costs of asbestosis and silicosis hospitalization in Italy (2001-2018) : Costs of asbestosis and silicosis hospitalization. 61
33404732 2021
24
[Differential expression of PRDX4 in alveolar macrophages of patients with silicosis]. 61
33535333 2021
25
[Research progress in pathogenesis of pneumoconiosis]. 61
33406565 2020
26
Mediation and Moderation of an Educational Intervention for Improving Intention to Practise Pneumoconiosis Prevention Among South Asian Construction Workers. 61
32991377 2020
27
Coal Workers' Pneumoconiosis and Other Mining-Related Lung Disease: New Manifestations of Illness in an Age-Old Occupation. 61
33153687 2020
28
Eye Tracking to Evaluate the Usability of an Online Pneumoconiosis Education Booklet in a Sample of South Asian Construction Workers. 61
32541364 2020
29
Assessment of pneumoconiosis in surface coal miners after implementation of a national radiographic surveillance program, United States, 2014-2019. 61
32914897 2020
30
COVID 19 pandemic: Mental health challenges of internal migrant workers of India. 61
32593122 2020
31
[Study on changes of pulmonary function in patients with pneumoconiosis in three years]. 61
33406545 2020
32
Health Disparities in Environmental and Occupational Lung Disease. 61
33153683 2020
33
Occupational Contributions to Interstitial Lung Disease. 61
33153688 2020
34
Superior mediastinal lymphadenopathy by silicosis mimicking metastasis of papillary thyroid carcinoma - Case report and literature review. 61
31899060 2020
35
Telomerase gene variants and telomere shortening in patients with silicosis or asbestosis. 61
33323453 2020
36
[A comparative study on diagnosis of silicosis by digital and high kV film-screen chest radiography]. 61
33406553 2020
37
Pneumoconiosis with a Sarcoid-Like Reaction Other than Beryllium Exposure: A Case Report and Literature Review. 61
33266389 2020
38
Silica-related diseases in the modern world. 61
31989662 2020
39
Transplantation for work-related lung disease in the USA. 61
32859693 2020
40
A Landscape of lncRNA Expression Profile and the Predictive Value of a Candidate lncRNA for Silica-Induced Pulmonary Fibrosis. 61
33202189 2020
41
Causes of death among Federal Black Lung Benefits Program beneficiaries enrolled in Medicare, 1999-2016. 61
32914887 2020
42
Progression of coal workers' pneumoconiosis absent further exposure. 61
32788293 2020
43
[Application of SF-36 scale in the survey of quality of life of occupational disease patients]. 61
33287480 2020
44
Percutaneous CT-guided lung biopsy for the diagnosis of persistent pulmonary consolidation. 61
32811758 2020
45
The impacts of coal dust on miners' health: A review. 61
32763275 2020
46
Oil red O staining for lipid-laden macrophage index of bronchoalveolar lavage: interobserver agreement and challenges to interpretation. 61
32674937 2020
47
[Analysis of the diagnotic results and complications of pneumoconiosis patients with different insurance types]. 61
33142374 2020
48
[Analysis of the diagnostic value of combined different chest X-ray image features for pneumoconiosis-associated tuberculosis]. 61
33142383 2020
49
[Epidemiological characteristics of pneumoconiosis in Gansu Province from 2010 to 2018]. 61
33142377 2020
50
Transcriptome profile analysis reveals a silica-induced immune response and fibrosis in a silicosis rat model. 61
32721576 2020
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Variations for Anthracosis

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Expression for Anthracosis

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Search GEO for disease gene expression data for Anthracosis.
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Pathways for Anthracosis

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Pathways related to Anthracosis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 65
Show member pathways
 13.3 TNF TGFB1 IL6 IL1B CXCL8 CCL2
2
PAK Pathway 63
Show member pathways
 13.25 TNF TGFB1 IL6 IL1B CXCL8 CCL2
3
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.02 TNF TGFB1 IL6 IL1B CXCL8 CCL2
4
Human cytomegalovirus infection 36
Show member pathways
 12.89 TNF IL6 IL1B CXCL8 CCL2
5
Allograft rejection 36 1
Show member pathways
 12.82 TNF TGFB1 IL6 IL1B CXCL8
6
Measles 36
Show member pathways
 12.8 TNF IL6 IL1B CXCL8 CCL2
7
T cell receptor signaling pathway 36
Show member pathways
 12.56 TNF TGFB1 IL6 IL1B
8
Th17 cell differentiation 36
Show member pathways
 12.55 TNF TGFB1 IL6 IL1B
9
Immune response IL-23 signaling pathway 23
Show member pathways
 12.54 TNF IL6 IL1B CCL2
10
IL-17 Family Signaling Pathways 64
Show member pathways
 12.32 TNF IL6 IL1B CXCL8 CCL2
11
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.31 TNF IL6 CXCL8 CCL2
12
Folate Metabolism 1
Show member pathways
 12.31 TNF IL6 IL1B CCL2
13
Toll Comparative Pathway 63
Show member pathways
 12.29 TNF IL6 IL1B CXCL8
14
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.24 TNF TGFB1 IL6 IL1B CXCL8
15
Tuberculosis 36
12.23 TNF TGFB1 IL6 IL1B
16
Bacterial infections in CF airways 23
Show member pathways
 12.17 TNF IL6 IL1B CXCL8
17
NOD-like receptor signaling pathway 36
12.17 TNF IL6 IL1B CXCL8 CCL2 CARD8
18
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.16 TNF IL6 IL1B CXCL8
19
Yersinia infection 36
12.03 TNF IL6 IL1B CXCL8 CCL2
20
TNF signaling pathway 36
11.96 TNF IL6 IL1B CCL2
21
Senescence and Autophagy in Cancer 1
11.92 TGFB1 IL6 IL1B CXCL8
22
Spinal Cord Injury 1
11.92 TNF TGFB1 IL6 IL1B CXCL8 CCL2
23
NF-kappa B signaling pathway 36
11.9 TNF IL1B CXCL8
24
Amoebiasis 36
11.88 TNF TGFB1 IL6 IL1B CXCL8
25
Hematopoietic cell lineage 36
11.87 TNF IL6 IL1B
26
Interleukin-4 and 13 signaling 65
11.86 TNF TGFB1 IL6 IL1B CXCL8 CCL2
27
Cytokine production by Th17 cells in CF (Mouse model) 23
Show member pathways
 11.84 TGFB1 IL6 CXCL8
28
Th17 Differentiation Pathway 64
Show member pathways
 11.83 TGFB1 IL6 IL1B
29
Th1 Differentiation Pathway 64
Show member pathways
 11.75 TNF TGFB1 IL6 IL1B
30
Pertussis 36
11.74 TNF IL6 IL1B CXCL8
31
AGE-RAGE signaling pathway in diabetic complications 36
11.73 TNF TGFB1 IL6 IL1B CXCL8 CCL2
32
Dendritic Cells Developmental Lineage Pathway 64
11.72 TNF TGFB1 IL6 IL1B
33
IgA-Producing B Cells in the Intestine 64
11.68 TNF TGFB1 IL6
34
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.64 TNF IL6 IL1B CXCL8
35
Rheumatoid arthritis 36
11.6 TNF TGFB1 IL6 IL1B CXCL8 CCL2
36
Legionellosis 36
11.57 TNF IL6 IL1B CXCL8
37
Hepatitis C and Hepatocellular Carcinoma 1
11.56 TGFB1 IL6 CXCL8
38
MSP-RON Signaling 63
11.52 TNF IL1B CCL2
39
Aryl Hydrocarbon Receptor Pathway 1
11.52 TNF TGFB1 IL1B
40
Interleukin-10 signaling 65
11.49 TNF IL6 IL1B CXCL8 CCL2
41
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.48 TNF IL6 IL1B
42
African trypanosomiasis 36
11.39 TNF IL6 IL1B
43
IL-10 Pathway 63
11.36 TNF IL6 IL1B
44
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.34 IL6 CXCL8 CCL2
45
Development and heterogeneity of the ILC family 1
11.3 TNF IL6 IL1B
46
Antifolate resistance 36
11.28 TNF IL6 IL1B
47
Lung fibrosis 1
11.23 TNF TGFB1 IL6 IL1B CXCL8 CCL2
48
Cytokines and Inflammatory Response 1
11.22 TNF TGFB1 IL6 IL1B
49
Overview of nanoparticle effects 1
11.05 TNF IL6 CXCL8
50
G-protein signaling_Rap2B regulation pathway 23
10.99 TNF TGFB1 IL6 IL1B CXCL8 CCL2
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GO Terms for Anthracosis

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Cellular components related to Anthracosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 TNF TGFB1 SCGB1A1 MIR18A IL6 IL1B

Biological processes related to Anthracosis according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.02 TNF TGFB1 IL6 IL1B CXCL8
2 immune response GO:0006955 10.01 TNF IL6 IL1B CXCL8 CCL2
3 MAPK cascade GO:0000165 9.94 TNF TGFB1 IL1B CCL2
4 inflammatory response GO:0006954 9.88 TNF TGFB1 IL6 IL1B CXCL8 CCL2
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.85 TNF IL6 IL1B
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.84 TNF TGFB1 IL6 IL1B
7 positive regulation of interleukin-6 production GO:0032755 9.83 TNF IL6 IL1B
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.83 TNF TGFB1 IL6
9 response to organic substance GO:0010033 9.82 TNF TGFB1 SCGB1A1
10 regulation of insulin secretion GO:0050796 9.8 TNF IL6 IL1B
11 response to glucocorticoid GO:0051384 9.8 TNF SCGB1A1 IL6
12 positive regulation of interleukin-8 production GO:0032757 9.77 TNF IL6 IL1B
13 humoral immune response GO:0006959 9.77 TNF IL6 CCL2
14 positive regulation of interleukin-1 beta production GO:0032731 9.76 TNF IL6 CARD8
15 negative regulation of fat cell differentiation GO:0045599 9.75 TNF TGFB1 IL6
16 positive regulation of epithelial to mesenchymal transition GO:0010718 9.73 TGFB1 IL6 IL1B
17 cellular response to organic cyclic compound GO:0071407 9.73 TNF TGFB1 IL1B CCL2
18 cytokine-mediated signaling pathway GO:0019221 9.73 TNF TGFB1 IL6 IL1B CXCL8 CCL2
19 cellular response to lipopolysaccharide GO:0071222 9.72 TNF IL6 IL1B CXCL8 CCL2
20 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.69 TNF IL1B CARD8
21 embryonic digestive tract development GO:0048566 9.68 TNF CXCL8
22 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.68 TNF IL1B
23 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.68 TNF IL1B
24 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.67 TNF IL6
25 PERK-mediated unfolded protein response GO:0036499 9.67 CXCL8 CCL2
26 positive regulation of vascular endothelial growth factor production GO:0010575 9.67 TGFB1 IL6 IL1B
27 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.66 TGFB1 IL6
28 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.66 TNF TGFB1
29 negative regulation of neurogenesis GO:0050768 9.65 TNF IL6 IL1B
30 regulation of establishment of endothelial barrier GO:1903140 9.64 TNF IL1B
31 negative regulation of lipid storage GO:0010888 9.63 TNF IL6
32 positive regulation of glial cell proliferation GO:0060252 9.63 TNF IL6 IL1B
33 positive regulation of mononuclear cell migration GO:0071677 9.61 TNF TGFB1
34 positive regulation of fever generation GO:0031622 9.57 TNF IL1B
35 sequestering of triglyceride GO:0030730 9.55 TNF IL1B
36 positive regulation of neuroinflammatory response GO:0150078 9.54 TNF IL6 IL1B
37 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.52 TNF IL1B
38 vascular endothelial growth factor production GO:0010573 9.33 TNF IL6 IL1B
39 protein kinase B signaling GO:0043491 9.26 TNF TGFB1 IL1B CCL2
40 lipopolysaccharide-mediated signaling pathway GO:0031663 8.92 TNF TGFB1 IL1B CCL2

Molecular functions related to Anthracosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 TNF TGFB1 IL6 IL1B CXCL8 CCL2
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Sources for Anthracosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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