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MCID: ANT018
MIFTS: 46

Anthracosis

Categories: Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Anthracosis

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MalaCards integrated aliases for Anthracosis:

Name: Anthracosis 12 45 15 17 74
Coal Workers' Pneumoconiosis 12 77
Pneumoconiosis 54 74
Black Lung 12 3
Coal Worker's Pneumoconiosis 54
Coal Miner's Pneumoconiosis 12
Coal Workers Pneumoconiosis 56
Coal Workers' Lung 12
Black Lung Disease 54
Melanoedema 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:10327
ICD9CM 36 500
MeSH 45 D055008
NCIt 51 C34390
SNOMED-CT 69 29422001
ICD10 34 J60
Sources

Summaries for Anthracosis

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CDC : 3 The pneumoconioses are a group of interstitial lung diseases caused by the inhalation of certain dusts and the lung tissue’s reaction to the dust. The principal cause of the pneumoconioses is work-place exposure; environmental exposures have rarely given rise to these diseases.

MalaCards based summary : Anthracosis, also known as coal workers' pneumoconiosis, is related to pneumoconiosis and nontuberculous mycobacterial lung disease. An important gene associated with Anthracosis is CCL2 (C-C Motif Chemokine Ligand 2), and among its related pathways/superpathways are Selenium Micronutrient Network and Toxoplasmosis. The drugs Iron and Nutrients have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and prostate.

Wikipedia : 77 Coal workers'' pneumoconiosis (CWP), also known as black lung disease or black lung, is caused by... more...

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Related Diseases for Anthracosis

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Diseases related to Anthracosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 pneumoconiosis 33.5 CCL2 HSPA1L SOD1 TNF
2 nontuberculous mycobacterial lung disease 31.8 BMP6 TNF
3 silicosis 30.5 CCL2 TNF
4 pulmonary sarcoidosis 30.0 CCL2 TNF
5 pulmonary fibrosis, idiopathic 30.0 BMP6 CCL2 TNF
6 kaolin pneumoconiosis 12.5
7 pneumoconiosis due to talc 12.4
8 graphite pneumoconiosis 12.2
9 mixed mineral dust pneumoconiosis 12.1
10 labrador lung 12.1
11 slate pneumoconiosis 12.0
12 caplan's syndrome 12.0
13 aluminosis 11.8
14 silicosiderosis 11.8
15 baritosis 11.6
16 berylliosis 11.6
17 siderosis 11.4
18 interstitial lung disease 11.0
19 bronchitis 10.4
20 pulmonary fibrosis 10.3
21 pulmonary tuberculosis 10.3
22 congenital cytomegalovirus 10.3 CCL2 TNF
23 stachybotrys chartarum 10.3 CCL2 TNF
24 arthritis 10.3
25 lung disease 10.3
26 stromal keratitis 10.3 CCL2 TNF
27 pleural tuberculosis 10.3 CCL2 TNF
28 tuberculous meningitis 10.3 CCL2 TNF
29 dengue shock syndrome 10.3 CCL2 TNF
30 complex regional pain syndrome 10.2 CCL2 TNF
31 lymphadenitis 10.2
32 adenocarcinoma 10.2
33 viral encephalitis 10.2 CCL2 TNF
34 rheumatoid arthritis 10.2
35 extrinsic cardiomyopathy 10.2 CCL2 TNF
36 autoimmune uveitis 10.2 CCL2 TNF
37 chikungunya 10.2 CCL2 TNF
38 pleurisy 10.2 CCL2 TNF
39 pyelonephritis 10.2 CCL2 TNF
40 leptospirosis 10.2 CCL2 TNF
41 temporal arteritis 10.2 CCL2 TNF
42 pneumonia 10.2
43 neuritis 10.2 CCL2 TNF
44 severe acute respiratory syndrome 10.2 CCL2 TNF
45 arteries, anomalies of 10.2
46 pulmonary disease, chronic obstructive 10.2
47 coronary artery anomaly 10.2
48 byssinosis 10.2
49 fasciitis 10.1 BMP6 TNF
50 rasmussen encephalitis 10.1 BMP6 TNF

Comorbidity relations with Anthracosis via Phenotypic Disease Network (PDN): (show all 14)


Bronchitis Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Intermediate Coronary Syndrome Ischemic Heart Disease
Pneumoconiosis Postinflammatory Pulmonary Fibrosis
Prostate Cancer Prostatic Hypertrophy
Respiratory Failure Silicosis

Graphical network of the top 20 diseases related to Anthracosis:



Diseases related to Anthracosis
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Symptoms & Phenotypes for Anthracosis

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Drugs & Therapeutics for Anthracosis

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Drugs for Anthracosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved, Experimental Phase 4 7439-89-6, 15438-31-0 27284 23925
2 Nutrients Phase 4
3 Micronutrients Phase 4
4 Liver Extracts Phase 4
5 Trace Elements Phase 4
6
Amlodipine Approved Phase 2, Phase 3 88150-42-9 2162
7
Metoprolol Approved, Investigational Phase 2, Phase 3 37350-58-6, 51384-51-1 4171
8
Isoniazid Approved, Investigational Phase 3,Not Applicable 54-85-3 3767
9
Rifampicin Approved Phase 3,Not Applicable 13292-46-1 5381226 5458213
10
Rifapentine Approved, Investigational Phase 3,Not Applicable 61379-65-5 6323497
11
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
12 Calcium, Dietary Phase 2, Phase 3
13 Adrenergic Agents Phase 2, Phase 3
14 Adrenergic beta-1 Receptor Antagonists Phase 2, Phase 3
15 Sympatholytics Phase 2, Phase 3
16 Neurotransmitter Agents Phase 2, Phase 3
17 Anti-Arrhythmia Agents Phase 2, Phase 3
18 Hormones Phase 2, Phase 3
19 calcium channel blockers Phase 2, Phase 3
20 Adrenergic Antagonists Phase 2, Phase 3
21 Vasodilator Agents Phase 2, Phase 3
22 Autonomic Agents Phase 2, Phase 3
23 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 1
24 Antihypertensive Agents Phase 2, Phase 3
25 Adrenergic beta-Antagonists Phase 2, Phase 3
26 Anti-Bacterial Agents Phase 3,Not Applicable
27 Antimetabolites Phase 3,Not Applicable
28 Nucleic Acid Synthesis Inhibitors Phase 3,Not Applicable
29 Antibiotics, Antitubercular Phase 3,Not Applicable
30 Cytochrome P-450 CYP3A Inducers Phase 3,Not Applicable
31 Antitubercular Agents Phase 3,Not Applicable
32 Lipid Regulating Agents Phase 3,Not Applicable
33 Hypolipidemic Agents Phase 3,Not Applicable
34 Anti-Infective Agents Phase 3,Not Applicable
35 Immunologic Factors Phase 3
36 Vaccines Phase 3
37
Infliximab Approved Phase 1, Phase 2 170277-31-3
38 Mitogens Phase 1, Phase 2
39 Anti-Inflammatory Agents Phase 1, Phase 2
40 Antirheumatic Agents Phase 1, Phase 2,Phase 2
41 Analgesics, Non-Narcotic Phase 1, Phase 2
42 Mesalamine Phase 1, Phase 2 89-57-6
43 Analgesics Phase 1, Phase 2
44 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
45 Gastrointestinal Agents Phase 1, Phase 2
46 Dermatologic Agents Phase 1, Phase 2
47
Heparin Approved, Investigational 9005-49-6 46507594 772
48
Deferiprone Approved 30652-11-0 2972
49 Xenon Experimental Early Phase 1 7440-63-3
50 Pharmaceutical Solutions

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study) Completed NCT01736540 Phase 4
2 Effects of Metoprolol and Amlodipine on Cardiac Remodeling, Arrhythmias and Blood Pressure Variation in Hypertensive Patients With Sleep Apnea Syndrome Unknown status NCT02408172 Phase 2, Phase 3 Amlodipine;metoprolol
3 Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention Unknown status NCT02430259 Phase 3 Weekly INH / RRT given by DOT
4 Trial to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine GSK2186877A in Adults 65 Year of Age and Older Completed NCT00753272 Phase 3
5 Safety Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat Silicosis Completed NCT01977131 Phase 1, Phase 2
6 Targeting Oxidative Stress in Chronic Beryllium Disease Completed NCT01088243 Phase 1, Phase 2 Mesalamine;Placebo
7 Beryllium Infliximab Study: Clinical Interventional Trial Terminated NCT00111917 Phase 1, Phase 2 Infliximab
8 Human Umbilical Cord-Mesenchymal Stem Cells for Pneumoconiosis Unknown status NCT02790762 Phase 1
9 Safety of Stem Cells Intrabronchial Instillation for Silicosis Completed NCT01239862 Phase 1
10 A Study on Pneumoconiosis Treated With Whole-lung Lavage Combined With Mesenchymal Stem Cells Active, not recruiting NCT02668068 Phase 1
11 The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD) Unknown status NCT02596347
12 Oscillation Mechanics of the Respiratory System Asbestos Exposed: Early Diagnosis Unknown status NCT02280343
13 Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01338064
14 DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01329003
15 Assessment of Iron Deposition in Major Organs of Hemodialysis Patients Unknown status NCT01169961
16 Comprehensive Risk Assessment of People With Silicosis: A Population-based Study Completed NCT02794701
17 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
18 Oscillation Mechanics of the Respiratory System in Never-smoking Patients With Silicosis Completed NCT01725971
19 Observational Study of Deferiprone (Ferriprox®) in the Treatment of Superficial Siderosis Completed NCT01284127
20 A Prospective Safety Follow Up Study Of Subjects Enrolled In Study A4321001 And Who Have Received Drug Product Completed NCT00471224
21 Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging Completed NCT02527330
22 Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and Sarcoidosis Completed NCT00560989
23 fMRI of the Brainstem in Migraine Sufferers and Controls. Does Iron Deposition Correlate With Progression of Disease? Completed NCT00868556
24 Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Disease (CBD) Recruiting NCT02604693
25 Short Course Rifapentine and Isoniazid for the Preventive Treatment of Tuberculosis(SCRIPT-TB) Recruiting NCT03900858 Not Applicable Isoniazid；Rifapentine
26 Cortical Superficial Siderosis and Risk of Recurrent Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy. Recruiting NCT03464344 Not Applicable
27 Superficial Siderosis in Patients With Suspected Cerebral Amyloid Angiopathy Active, not recruiting NCT01856699
28 Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders Not yet recruiting NCT02748798 Early Phase 1 HP 3He;HP 129Xe;PFP;SF6

Search NIH Clinical Center for Anthracosis

Cochrane evidence based reviews: anthracosis

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Genetic Tests for Anthracosis

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Anatomical Context for Anthracosis

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MalaCards organs/tissues related to Anthracosis:

42
Lung, Heart, Prostate, Bone, Liver, Lymph Node, Bone Marrow
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Publications for Anthracosis

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Articles related to Anthracosis:

(show top 50) (show all 339)
# Title Authors Year
1
Pleural anthracosis presenting with massive effusion: a rare entity. ( 30519469 )
2019
2
Pleural anthracosis as an indicator of lifetime exposure to urban air pollution: An autopsy-based study in Sao Paulo. ( 30884435 )
2019
3
Extracellular Histones Promote Pulmonary Fibrosis in Patients With Coal Workers' Pneumoconiosis. ( 30308624 )
2019
4
Anthracosis with a Mosaic Attenuation Pattern. ( 29279499 )
2018
5
Black lungs and big nodes: A case of airway anthracosis with bronchial anthracofibrosis. ( 29892540 )
2018
6
Epicardial anthracosis in a patient undergoing coronary artery bypass graft surgery. ( 30367815 )
2018
7
Estimated economic costs of coal workers' pneumoconiosis among coal workers redeployed from the Fuxin mining group in China. ( 29116190 )
2018
8
Association Analysis Identifies New Risk Loci for Coal Workers' Pneumoconiosis in Han Chinese Men. ( 29394417 )
2018
9
Comment on Tomaskova et al. Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013. Int. J. Environ. Res. Public Health, 2017, 14, 269. ( 29415464 )
2018
10
TNFR/TNF-α signaling pathway regulates apoptosis of alveolar macrophages in coal workers' pneumoconiosis. ( 29416696 )
2018
11
A response to the Comment on Tomaskova et al. Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013. Int. J. Environ. Res. Public Health, 2017, 14, 269 by the Author Mei Yong. ( 29438277 )
2018
12
Establishment and application of an index system for prevention of coal workers' pneumoconiosis: a Delphi and analytic hierarchy process study in four state-owned coal enterprises of China. ( 29563194 )
2018
13
Prevalence of latent tuberculosis infection among coal workers' pneumoconiosis patients in China: a cross-sectional study. ( 29642880 )
2018
14
Continued increase in lung transplantation for coal workers' pneumoconiosis in the United States. ( 29732582 )
2018
15
Continued Increase in Prevalence of Coal Workers' Pneumoconiosis in the United States, 1970-2017. ( 30024799 )
2018
16
Coal Workers' Pneumoconiosis-Attributable Years of Potential Life Lost to Life Expectancy and Potential Life Lost Before Age 65 Years - United States, 1999-2016. ( 30070982 )
2018
17
Association between tumor necrosis factor-α -308 Gauss/A polymorphism and risk of silicosis and coal workers pneumoconiosis in Chinese population. ( 30257124 )
2018
18
Association of single nucleotide polymorphisms in the CYBA gene with coal workers' pneumoconiosis in the Han Chinese population. ( 30654669 )
2018
19
A potential pitfall in the use of 68Ga-PSMA PET/CT: Anthracosis. ( 27666999 )
2017
20
Re: Anthracosis Mimicking Mediastinal Lymph Node Metastases With 18F-FCholine in High-Risk Prostate Cancer. ( 27749414 )
2017
21
Multi-Gene Expression in Anthracosis of the Lungs as One of the Risk Factors for Non-Small Cell Lung Cancer ( 29172290 )
2017
22
Cross-section analysis of coal workers' pneumoconiosis and higher brachial-ankle pulse wave velocity within Kailuan study. ( 28148238 )
2017
23
Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013. ( 28272360 )
2017
24
The association of LAMB1 polymorphism and expression changes with the risk of coal workers' pneumoconiosis. ( 28444932 )
2017
25
Survival Analysis of Coal Workers' Pneumoconiosis (CWP) Patients in a State-Owned Mine in the East of China from 1963 to 2014. ( 28481235 )
2017
26
Polymorphisms in autophagy related genes and the coal workers' pneumoconiosis in a Chinese population. ( 28844669 )
2017
27
LRBA Gene Polymorphisms and Risk of Coal Workers' Pneumoconiosis: A Case-Control Study from China. ( 28953250 )
2017
28
Endobronchial anthracosis with concurrent primary lung cancer. ( 26917802 )
2016
29
Inguinal Lymph Node Anthracosis: A Case Report. ( 27536493 )
2016
30
Pulmonary anthracosis mimicking lung metastases in pediatric rhabdomyosarcoma. ( 27592612 )
2016
31
Lung transplantation is increasingly common among patients with coal workers' pneumoconiosis. ( 26725917 )
2016
32
Estimates and Predictions of Coal Workers' Pneumoconiosis Cases among Redeployed Coal Workers of the Fuxin Mining Industry Group in China: A Historical Cohort Study. ( 26845337 )
2016
33
Pneumoconiosis Redux. Coal Workers' Pneumoconiosis and Silicosis Are Still a Problem. ( 26977968 )
2016
34
Platelet Indices in Patients with Coal Workers' Pneumoconiosis. ( 27107875 )
2016
35
Coal workers' pneumoconiosis: an Australian perspective. ( 27318401 )
2016
36
Plasma LncRNA-ATB, a Potential Biomarker for Diagnosis of Patients with Coal Workers' Pneumoconiosis: A Case-Control Study. ( 27556453 )
2016
37
Polymorphisms in Long Noncoding RNA H19 Contribute to the Protective Effects of Coal Workers' Pneumoconiosis in a Chinese Population. ( 27626436 )
2016
38
Screening and Preliminary Verification of a Phage Display Single-Chain Antibody Library Against Coal Workers' Pneumoconiosis. ( 27930489 )
2016
39
CT differentiation of enlarged mediastinal lymph node due to anthracosis from metastatic lymphadenopathy: a comparative study proven by endobronchial US-guided transbronchial needle aspiration. ( 25616268 )
2015
40
Anthracosis mimicking mediastinal lymph node metastases with 18F-FCholine in high-risk prostate cancer. ( 25674859 )
2015
41
Clinico-radiological profile and risk factors in patients with anthracosis. ( 25814792 )
2015
42
A fire death with a rare finding: anthracosis or soot embolism? ( 25890616 )
2015
43
Percutaneous treatment for pulmonary hypertension caused by pulmonary artery stenosis due to anthracosis. ( 25946371 )
2015
44
Anthracosis: An unusual cause of vocal fold paralysis. ( 26214668 )
2015
45
Comparison of samples obtained from bronchoscopy of patients with and without bronchial anthracosis for investigating the prevalence of Mycobacterium tuberculosis. ( 26405675 )
2015
46
Risk factors and maximum standardized uptake values within lymph nodes of anthracosis diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration. ( 26422878 )
2015
47
Serum levels of IL-8 and ICAM-1 as biomarkers for progressive massive fibrosis in coal workers' pneumoconiosis. ( 25653483 )
2015
48
Cost-Effectiveness of Coal Workers' Pneumoconiosis Prevention Based on Its Predicted Incidence within the Datong Coal Mine Group in China. ( 26098706 )
2015
49
Comparison of the Cumulative Incidence Rates of Coal Workers' Pneumoconiosis between 1970 and 2013 among Four State-Owned Colliery Groups in China. ( 26133134 )
2015
50
Prevalence Characteristics of Coal Workers' Pneumoconiosis (CWP) in a State-Owned Mine in Eastern China. ( 26184259 )
2015
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Variations for Anthracosis

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Expression for Anthracosis

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Search GEO for disease gene expression data for Anthracosis.
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Pathways for Anthracosis

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Pathways related to Anthracosis according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Selenium Micronutrient Network 1
Show member pathways
 11.83 CCL2 SOD1 TNF
2
Toxoplasmosis 38
Show member pathways
 11.7 HSPA1L LAMB1 TNF
3
Lung fibrosis 1
11.29 CCL2 TNF
4
Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) 23
Show member pathways
 11.25 HSPA1L SOD1
5
Legionellosis 38
11.2 HSPA1L TNF
6
Interleukin-10 signaling 67
11.12 CCL2 TNF
7
Malaria 38
11.09 CCL2 TNF
8
MSP-RON Signaling 65
11.05 CCL2 TNF
9
G-protein signaling_RhoB regulation pathway 23
10.56 BMP6 CCL2 TNF
10
G-protein signaling_Rap2B regulation pathway 23
10.16 BMP6 CCL2 LAMB1 TNF
11
LDL Oxidation in Atherogenesis 65
9.83 CCL2 TNF
Sources

GO Terms for Anthracosis

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Cellular components related to Anthracosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 BMP6 CCL2 LAMB1 SOD1 TNF

Biological processes related to Anthracosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of epithelial cell proliferation GO:0050679 9.4 BMP6 LAMB1
2 cellular iron ion homeostasis GO:0006879 9.37 BMP6 SOD1
3 humoral immune response GO:0006959 9.32 CCL2 TNF
4 negative regulation of viral genome replication GO:0045071 9.26 BANF1 TNF
5 protein kinase B signaling GO:0043491 9.16 CCL2 TNF
6 lipopolysaccharide-mediated signaling pathway GO:0031663 8.96 CCL2 TNF
7 positive regulation of cytokine production GO:0001819 8.62 SOD1 TNF

Molecular functions related to Anthracosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 BMP6 CCL2 TNF
Sources

Sources for Anthracosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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