MCID: ANT002
MIFTS: 34

Anti-Basement Membrane Glomerulonephritis

Categories: Immune diseases, Nephrological diseases, Respiratory diseases

Aliases & Classifications for Anti-Basement Membrane Glomerulonephritis

MalaCards integrated aliases for Anti-Basement Membrane Glomerulonephritis:

Name: Anti-Basement Membrane Glomerulonephritis 12 15 72
Anti-Gbm Glomerulonephritis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4780
NCIt 50 C35798
UMLS 72 C1332309

Summaries for Anti-Basement Membrane Glomerulonephritis

Disease Ontology : 12 A Goodpasture syndrome that is characterized by damage to only kidney capillaries.

MalaCards based summary : Anti-Basement Membrane Glomerulonephritis, also known as anti-gbm glomerulonephritis, is related to goodpasture syndrome and kidney disease. An important gene associated with Anti-Basement Membrane Glomerulonephritis is EDA (Ectodysplasin A), and among its related pathways/superpathways are Integrin Pathway and Pathways in cancer. The drugs Pentoxifylline and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and lymph node, and related phenotype is immune system.

Related Diseases for Anti-Basement Membrane Glomerulonephritis

Graphical network of the top 20 diseases related to Anti-Basement Membrane Glomerulonephritis:



Diseases related to Anti-Basement Membrane Glomerulonephritis

Symptoms & Phenotypes for Anti-Basement Membrane Glomerulonephritis

MGI Mouse Phenotypes related to Anti-Basement Membrane Glomerulonephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.1 COL4A3 COL4A4 COL4A5 ICOS MIF MMP12

Drugs & Therapeutics for Anti-Basement Membrane Glomerulonephritis

Drugs for Anti-Basement Membrane Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
2
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
3
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
4
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
6
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
7 Hormone Antagonists Phase 3
8 Antiemetics Phase 3
9 glucocorticoids Phase 3
10 Gastrointestinal Agents Phase 3
11 Anti-Inflammatory Agents Phase 3
12 Free Radical Scavengers Phase 3
13 Neuroprotective Agents Phase 3
14 Antioxidants Phase 3
15 Methylprednisolone Acetate Phase 3
16 Immunosuppressive Agents Phase 3
17 Hormones Phase 3
18 Protective Agents Phase 3
19 Peripheral Nervous System Agents Phase 3
20 Radiation-Protective Agents Phase 3
21 Antineoplastic Agents, Hormonal Phase 3
22 Platelet Aggregation Inhibitors Phase 3
23 Phosphodiesterase Inhibitors Phase 3
24 Vasodilator Agents Phase 3
25 Autonomic Agents Phase 3
26 Prednisolone acetate Phase 3
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
28 Antibodies
29 Immunologic Factors
30 Immunoglobulins
31 Autoantibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Immunoadsorption in Anti-glomerular Basement Membrane Glomerulonephritis; a Pilot Study Recruiting NCT02765789 Phase 4
2 Clinical Efficacy of Combined Pentoxifylline and Conventional Immunosuppressive Regimens on Patients With Rapidly Progressive Glomerulonephritis Terminated NCT00354198 Phase 3 pentoxifylline;corticosteroids
3 Detection of Anti-glomerular Basement Membrane Antibodies (Anti-GBM): a Promising Biomarker for Lupus Nephritis (LN) Screening in Systemic Lupus Erythematosus (SLE) Patients? Recruiting NCT03664908

Search NIH Clinical Center for Anti-Basement Membrane Glomerulonephritis

Genetic Tests for Anti-Basement Membrane Glomerulonephritis

Anatomical Context for Anti-Basement Membrane Glomerulonephritis

MalaCards organs/tissues related to Anti-Basement Membrane Glomerulonephritis:

41
Kidney, T Cells, Lymph Node, Neutrophil, Endothelial, B Cells

Publications for Anti-Basement Membrane Glomerulonephritis

Articles related to Anti-Basement Membrane Glomerulonephritis:

(show top 50) (show all 127)
# Title Authors PMID Year
1
HLA-DR15-specific inhibition attenuates autoreactivity to the Goodpasture antigen. 38
31104947 2019
2
Group 1 innate lymphoid cells are involved in the progression of experimental anti-glomerular basement membrane glomerulonephritis and are regulated by peroxisome proliferator-activated receptor α. 38
31402171 2019
3
Antineutrophil cytoplasmic antibody and/or antiglomerular basement membrane antibody associated crescentic glomerulonephritis in combination with IgG4-related tubulointerstitial nephritis. 38
30183608 2019
4
Monotypic IgG1-kappa Atypical Anti-Glomerular Basement Membrane Nephritis: A Case Report. 38
31019927 2019
5
Development of anti-glomerular basement membrane glomerulonephritis during the course of IgA nephropathy: a case report. 38
30683055 2019
6
Falsely positive anti-glomerular basement membrane antibodies in a patient with hantavirus induced acute kidney injury - a case report. 38
30348108 2018
7
Genotype and Outcome After Kidney Transplantation in Alport Syndrome. 38
29854973 2018
8
Matrix metalloproteinase-12 deficiency attenuates experimental crescentic anti-glomerular basement membrane glomerulonephritis. 38
27862656 2018
9
Predicting Outcome in Patients with Anti-GBM Glomerulonephritis. 38
29162595 2018
10
CTGF in kidney fibrosis and glomerulonephritis. 38
30123390 2018
11
(5R)-5-hydroxytriptolide ameliorates anti-glomerular basement membrane glomerulonephritis in NZW mice by regulating Fcγ receptor signaling. 38
28880016 2018
12
Coexistence of Anti-Glomerular Basement Membrane Glomerulonephritis and Membranous Nephropathy in a Female Patient with Preserved Renal Function. 38
29269610 2017
13
ID3 may protect mice from anti‑GBM glomerulonephritis by regulating the differentiation of Th17 and Treg cells. 38
28990057 2017
14
Immunoadsorption in Anti-GBM Glomerulonephritis: Case Report in a Child and Literature Review. 38
29054981 2017
15
The pathogenicity of T cell epitopes on human Goodpasture antigen and its critical amino acid motif. 38
28296059 2017
16
Therapeutic effects and mechanism of conditioned media from human mesenchymal stem cells on anti-GBM glomerulonephritis in WKY rats. 38
27053690 2016
17
Aliskiren Regulates Neonatal Fc Receptor and IgG Metabolism with Attenuation of Anti-GBM Glomerulonephritis in Mice. 38
27560625 2016
18
Suppression of Rapidly Progressive Mouse Glomerulonephritis with the Non-Steroidal Mineralocorticoid Receptor Antagonist BR-4628. 38
26700873 2015
19
A case of antiglomerular basement membrane glomerulonephritis complicated by membranous nephropathy. 38
28509257 2014
20
Galectin-9 ameliorates anti-GBM glomerulonephritis by inhibiting Th1 and Th17 immune responses in mice. 38
24477688 2014
21
Suppression of experimental autoimmune glomerulonephritis by tryptophan. 38
24519862 2014
22
Identical twins:one with anti-glomerular basement membrane glomerulonephritis,the other with systemic lupus erythematosus. 38
24359316 2013
23
A case of anti-GBM glomerulonephritis superimposed on HBV-associated membranous nephropathy. 38
28509304 2013
24
Urinary cystatin C as a renal biomarker and its immunohistochemical localization in anti-GBM glomerulonephritis rats. 38
23791361 2013
25
MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation. 38
22419694 2012
26
[A case of anti-GBM glomerulonephritis and membranous nephropathy in a patient with primary biliary cirrhosis]. 38
24236349 2012
27
Anti-glomerular basement membrane glomerulonephritis complicated by thrombocytopenia. 38
23257527 2012
28
Tubular deficiency of von Hippel-Lindau attenuates renal disease progression in anti-GBM glomerulonephritis. 38
21925138 2011
29
c-fms blockade reverses glomerular macrophage infiltration and halts development of crescentic anti-GBM glomerulonephritis in the rat. 38
21519331 2011
30
Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1. 38
22046355 2011
31
Lack of collagen XVIII/endostatin exacerbates immune-mediated glomerulonephritis. 38
20616167 2010
32
Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis. 38
20660402 2010
33
Both complement and IgG fc receptors are required for development of attenuated antiglomerular basement membrane nephritis in mice. 38
19710463 2009
34
Invariant natural killer T cells and TGF-beta attenuate anti-GBM glomerulonephritis. 38
19470687 2009
35
IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen. 38
19357249 2009
36
Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat. 38
19188913 2009
37
Loss of a renal graft due to recurrence of anti-GBM disease despite rituximab therapy. 38
19087095 2009
38
[Anti-GBM glomerulonephritis and RPGN]. 38
19378793 2009
39
Differential effects of rapamycin in anti-GBM glomerulonephritis. 38
18480312 2008
40
Spontaneous recovery from early glomerular inflammation is associated with resistance to anti-GBM glomerulonephritis: tolerance and autoimmune tissue injury. 38
18054199 2008
41
Inhibition of proinflammatory genes in anti-GBM glomerulonephritis by targeted dexamethasone-loaded AbEsel liposomes. 38
18160627 2008
42
Role of macrophage migration inhibition factor in kidney disease. 38
18663334 2008
43
A pathogenic role for JNK signaling in experimental anti-GBM glomerulonephritis. 38
17597698 2007
44
Histamine ameliorates anti-glomerular basement membrane antibody-induced glomerulonephritis in rats. 38
17568783 2007
45
Inhibition of CXCL16 attenuates inflammatory and progressive phases of anti-glomerular basement membrane antibody-associated glomerulonephritis. 38
17456756 2007
46
Patient with antibody-negative relapse of Goodpasture syndrome. 38
17474560 2007
47
Sequential development of pulmonary renal syndrome associated with c-ANCA 3 years after development of anti-GBM glomerulonephritis. 38
17210587 2007
48
Autoepitopes and alloepitopes of type IV collagen: role in the molecular pathogenesis of anti-GBM antibody glomerulonephritis. 38
17570938 2007
49
Concurrent anti-glomerular basement membrane disease and membranous glomerulonephritis: a case report and literature review. 38
16939068 2006
50
Anti-glomerular basement membrane glomerulonephritis: a morphologic study of 80 cases. 38
16613350 2006

Variations for Anti-Basement Membrane Glomerulonephritis

Expression for Anti-Basement Membrane Glomerulonephritis

Search GEO for disease gene expression data for Anti-Basement Membrane Glomerulonephritis.

Pathways for Anti-Basement Membrane Glomerulonephritis

Pathways related to Anti-Basement Membrane Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13 MMP12 COL4A5 COL4A4 COL4A3
2 12.45 COL4A5 COL4A4 COL4A3
3
Show member pathways
12.44 COL4A5 COL4A4 COL4A3
4
Show member pathways
12.41 MMP12 COL4A5 COL4A4 COL4A3
5
Show member pathways
12.26 COL4A5 COL4A4 COL4A3
6
Show member pathways
11.9 MMP12 COL4A5 COL4A4 COL4A3
7
Show member pathways
11.85 COL4A5 COL4A4 COL4A3
8 11.61 COL4A5 COL4A4 COL4A3
9 11.59 COL4A5 COL4A4 COL4A3
10 11.51 COL4A5 COL4A4 COL4A3
11 11.37 COL4A5 COL4A4 COL4A3
12 11.27 ICOS HAVCR1
13 11.12 COL4A5 COL4A4 COL4A3
14 10.93 COL4A5 COL4A4 COL4A3
15 10.71 MMP12 COL4A5 COL4A4 COL4A3
16 10.7 COL4A5 COL4A4 COL4A3
17 10.65 COL4A5 COL4A4 COL4A3

GO Terms for Anti-Basement Membrane Glomerulonephritis

Cellular components related to Anti-Basement Membrane Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 MMP12 MIF COL4A5 COL4A4 COL4A3
2 extracellular region GO:0005576 9.7 MMP12 MIF ICOS EDA COL4A5 COL4A4
3 extracellular matrix GO:0031012 9.56 MMP12 COL4A5 COL4A4 COL4A3
4 endoplasmic reticulum lumen GO:0005788 9.54 COL4A5 COL4A4 COL4A3
5 basement membrane GO:0005604 9.5 COL4A5 COL4A4 COL4A3
6 collagen trimer GO:0005581 9.26 EDA COL4A5 COL4A4 COL4A3
7 collagen type IV trimer GO:0005587 8.8 COL4A5 COL4A4 COL4A3

Biological processes related to Anti-Basement Membrane Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.33 COL4A5 COL4A4 COL4A3
2 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 8.96 COL4A5 COL4A3
3 glomerular basement membrane development GO:0032836 8.62 COL4A4 COL4A3

Molecular functions related to Anti-Basement Membrane Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.96 COL4A5 COL4A3
2 extracellular matrix structural constituent GO:0005201 8.8 COL4A5 COL4A4 COL4A3

Sources for Anti-Basement Membrane Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....