MCID: ANT002
MIFTS: 34

Anti-Basement Membrane Glomerulonephritis

Categories: Immune diseases, Nephrological diseases, Respiratory diseases

Aliases & Classifications for Anti-Basement Membrane Glomerulonephritis

MalaCards integrated aliases for Anti-Basement Membrane Glomerulonephritis:

Name: Anti-Basement Membrane Glomerulonephritis 12 15 74
Anti-Gbm Glomerulonephritis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4780
NCIt 51 C35798
UMLS 74 C1332309

Summaries for Anti-Basement Membrane Glomerulonephritis

Disease Ontology : 12 A Goodpasture syndrome that is characterized by damage to only kidney capillaries.

MalaCards based summary : Anti-Basement Membrane Glomerulonephritis, also known as anti-gbm glomerulonephritis, is related to goodpasture syndrome and glomerulonephritis. An important gene associated with Anti-Basement Membrane Glomerulonephritis is EDA (Ectodysplasin A), and among its related pathways/superpathways are Integrin Pathway and Focal Adhesion. The drugs Autoantibodies and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and neutrophil, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Anti-Basement Membrane Glomerulonephritis

Graphical network of the top 20 diseases related to Anti-Basement Membrane Glomerulonephritis:



Diseases related to Anti-Basement Membrane Glomerulonephritis

Symptoms & Phenotypes for Anti-Basement Membrane Glomerulonephritis

MGI Mouse Phenotypes related to Anti-Basement Membrane Glomerulonephritis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.43 COL4A3 COL4A4 COL4A5 ICOS MIF MMP12
2 immune system MP:0005387 9.1 COL4A3 COL4A4 COL4A5 ICOS MIF MMP12

Drugs & Therapeutics for Anti-Basement Membrane Glomerulonephritis

Drugs for Anti-Basement Membrane Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Autoantibodies Not Applicable
2 Immunologic Factors Not Applicable
3 Antibodies Not Applicable
4 Immunoglobulins Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Immunoadsorption in Anti-GBM Glomerulonephritis. Recruiting NCT02765789 Phase 4
2 Detection of Anti-glomerular Basement Membrane Antibodies (Anti-GBM): a Promising Biomarker for Lupus Nephritis (LN)? Recruiting NCT03664908 Not Applicable

Search NIH Clinical Center for Anti-Basement Membrane Glomerulonephritis

Genetic Tests for Anti-Basement Membrane Glomerulonephritis

Anatomical Context for Anti-Basement Membrane Glomerulonephritis

MalaCards organs/tissues related to Anti-Basement Membrane Glomerulonephritis:

42
Kidney, T Cells, Neutrophil

Publications for Anti-Basement Membrane Glomerulonephritis

Articles related to Anti-Basement Membrane Glomerulonephritis:

(show all 39)
# Title Authors Year
1
Predicting Outcome in Patients with Anti-GBM Glomerulonephritis. ( 29162595 )
2018
2
ID3 may protect mice from anti‑GBM glomerulonephritis by regulating the differentiation of Th17 and Treg cells. ( 28990057 )
2017
3
Immunoadsorption in Anti-GBM Glomerulonephritis: Case Report in a Child and Literature Review. ( 29054981 )
2017
4
Aliskiren Regulates Neonatal Fc Receptor and IgG Metabolism with Attenuation of Anti-GBM Glomerulonephritis in Mice. ( 27560625 )
2016
5
Therapeutic effects and mechanism of conditioned media from human mesenchymal stem cells on anti-GBM glomerulonephritis in WKY rats. ( 27053690 )
2016
6
Galectin-9 ameliorates anti-GBM glomerulonephritis by inhibiting Th1 and Th17 immune responses in mice. ( 24477688 )
2014
7
Urinary cystatin C as a renal biomarker and its immunohistochemical localization in anti-GBM glomerulonephritis rats. ( 23791361 )
2013
8
A case of anti-GBM glomerulonephritis superimposed on HBV-associated membranous nephropathy. ( 28509304 )
2013
9
Tubular deficiency of von Hippel-Lindau attenuates renal disease progression in anti-GBM glomerulonephritis. ( 21925138 )
2011
10
Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1. ( 22046355 )
2011
11
c-fms blockade reverses glomerular macrophage infiltration and halts development of crescentic anti-GBM glomerulonephritis in the rat. ( 21519331 )
2011
12
Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat. ( 19188913 )
2009
13
Invariant natural killer T cells and TGF-beta attenuate anti-GBM glomerulonephritis. ( 19470687 )
2009
14
Differential effects of rapamycin in anti-GBM glomerulonephritis. ( 18480312 )
2008
15
Spontaneous recovery from early glomerular inflammation is associated with resistance to anti-GBM glomerulonephritis: tolerance and autoimmune tissue injury. ( 18054199 )
2008
16
Inhibition of proinflammatory genes in anti-GBM glomerulonephritis by targeted dexamethasone-loaded AbEsel liposomes. ( 18160627 )
2008
17
Sequential development of pulmonary renal syndrome associated with c-ANCA 3 years after development of anti-GBM glomerulonephritis. ( 17210587 )
2007
18
A pathogenic role for JNK signaling in experimental anti-GBM glomerulonephritis. ( 17597698 )
2007
19
Immunohistochemical characterization of glomerular inflammatory cells and expression of adhesion molecules in anti-glomerular basement membrane (anti-GBM) glomerulonephritis induced in WKY rats with monoclonal anti-GBM antibodies of different subclasses. ( 16445816 )
2006
20
Characterization of the T-cell epitope that causes anti-GBM glomerulonephritis. ( 16105036 )
2005
21
Anti-GBM glomerulonephritis: a T cell-mediated autoimmune disease? ( 15179323 )
2004
22
Important role for macrophages in induction of crescentic anti-GBM glomerulonephritis in WKY rats. ( 15574997 )
2004
23
Expression of MMP-9 in mesangial cells and its changes in anti-GBM glomerulonephritis in WKY rats. ( 15480897 )
2004
24
Gene expression profiling of anti-GBM glomerulonephritis model: the role of NF-kappaB in immune complex kidney disease. ( 15496153 )
2004
25
Blockade of p38alpha MAPK ameliorates acute inflammatory renal injury in rat anti-GBM glomerulonephritis. ( 12538734 )
2003
26
Glucocorticoids stimulate p21(CIP1) in mesangial cells and in anti-GBM glomerulonephritis. ( 11318941 )
2001
27
Anti-GBM glomerulonephritis in mice lacking nitric oxide synthase type 2. ( 9551400 )
1998
28
Distinct contribution of Fc receptors and angiotensin II-dependent pathways in anti-GBM glomerulonephritis. ( 9767532 )
1998
29
Experimental anti-GBM glomerulonephritis induced in rats by immunization with synthetic peptides based on six alpha chains of human type IV collagen. ( 8778343 )
1996
30
Local macrophage proliferation in the progression of glomerular and tubulointerstitial injury in rat anti-GBM glomerulonephritis. ( 7474661 )
1995
31
Pernicious anemia, autoimmune hypothyroidism and rapidly progressive anti-GBM glomerulonephritis. ( 7882606 )
1994
32
Beta 2 integrin independent neutrophil recruitment and injury in anti-GBM glomerulonephritis in rabbits. ( 7698818 )
1994
33
The ICAM-1/LFA-1 interaction in glomerular leukocytic accumulation in anti-GBM glomerulonephritis. ( 7910869 )
1994
34
Glomerular fibrinolytic activity in anti-GBM glomerulonephritis in rabbits. ( 8231028 )
1993
35
Isologous monoclonal antibodies can induce anti-GBM glomerulonephritis in rats. ( 1460540 )
1992
36
Glomerular interleukin 1 production is dependent on macrophage infiltration in anti-GBM glomerulonephritis. ( 2002624 )
1991
37
Failure of two subsequent renal grafts by anti-GBM glomerulonephritis in Alport's syndrome: case report and review of the literature. ( 2206225 )
1990
38
Role of the plasma contact system in the pathogenesis of experimental anti-GBM glomerulonephritis. ( 3396222 )
1988
39
Toxic anti-GBM glomerulonephritis. ( 6831778 )
1983

Variations for Anti-Basement Membrane Glomerulonephritis

Expression for Anti-Basement Membrane Glomerulonephritis

Search GEO for disease gene expression data for Anti-Basement Membrane Glomerulonephritis.

Pathways for Anti-Basement Membrane Glomerulonephritis

Pathways related to Anti-Basement Membrane Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.96 COL4A3 COL4A4 COL4A5 MMP12
2
Show member pathways
12.51 COL4A3 COL4A4 COL4A5
3 12.45 COL4A3 COL4A4 COL4A5
4
Show member pathways
12.43 COL4A3 COL4A4 COL4A5
5
Show member pathways
12.41 COL4A3 COL4A4 COL4A5 MMP12
6
Show member pathways
12.24 COL4A3 COL4A4 COL4A5
7
Show member pathways
11.9 COL4A3 COL4A4 COL4A5 MMP12
8
Show member pathways
11.84 COL4A3 COL4A4 COL4A5
9 11.66 MIF MMP12
10 11.61 COL4A3 COL4A4 COL4A5
11 11.56 COL4A3 COL4A4 COL4A5
12 11.51 COL4A3 COL4A4 COL4A5
13 11.37 COL4A3 COL4A4 COL4A5
14 11.12 COL4A3 COL4A4 COL4A5
15 10.93 COL4A3 COL4A4 COL4A5
16 10.71 COL4A3 COL4A4 COL4A5 MMP12
17 10.7 COL4A3 COL4A4 COL4A5
18 10.64 COL4A3 COL4A4 COL4A5

GO Terms for Anti-Basement Membrane Glomerulonephritis

Cellular components related to Anti-Basement Membrane Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 COL4A3 COL4A4 COL4A5 MIF MMP12
2 extracellular region GO:0005576 9.7 COL4A3 COL4A4 COL4A5 EDA ICOS MIF
3 endoplasmic reticulum lumen GO:0005788 9.58 COL4A3 COL4A4 COL4A5
4 extracellular matrix GO:0031012 9.56 COL4A3 COL4A4 COL4A5 MMP12
5 basement membrane GO:0005604 9.5 COL4A3 COL4A4 COL4A5
6 collagen trimer GO:0005581 9.26 COL4A3 COL4A4 COL4A5 EDA
7 collagen type IV trimer GO:0005587 8.8 COL4A3 COL4A4 COL4A5

Biological processes related to Anti-Basement Membrane Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.33 COL4A3 COL4A4 COL4A5
2 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 8.96 COL4A3 COL4A5
3 glomerular basement membrane development GO:0032836 8.62 COL4A3 COL4A4

Molecular functions related to Anti-Basement Membrane Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.96 COL4A3 COL4A5
2 extracellular matrix structural constituent GO:0005201 8.8 COL4A3 COL4A4 COL4A5

Sources for Anti-Basement Membrane Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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