MCID: ANT002
MIFTS: 36

Anti-Basement Membrane Glomerulonephritis

Categories: Immune diseases, Nephrological diseases, Respiratory diseases

Aliases & Classifications for Anti-Basement Membrane Glomerulonephritis

MalaCards integrated aliases for Anti-Basement Membrane Glomerulonephritis:

Name: Anti-Basement Membrane Glomerulonephritis 12 15 71
Anti-Gbm Glomerulonephritis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4780
NCIt 49 C35798
UMLS 71 C1332309

Summaries for Anti-Basement Membrane Glomerulonephritis

Disease Ontology : 12 A Goodpasture syndrome that is characterized by damage to only kidney capillaries.

MalaCards based summary : Anti-Basement Membrane Glomerulonephritis, also known as anti-gbm glomerulonephritis, is related to glomerular disease and rapidly progressive glomerulonephritis. An important gene associated with Anti-Basement Membrane Glomerulonephritis is CFHR2 (Complement Factor H Related 2), and among its related pathways/superpathways are ECM-receptor interaction and Amoebiasis. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and lymph node, and related phenotype is immune system.

Related Diseases for Anti-Basement Membrane Glomerulonephritis

Diseases related to Anti-Basement Membrane Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
# Related Disease Score Top Affiliating Genes
1 glomerular disease 30.4 COL4A5 ALB
2 rapidly progressive glomerulonephritis 30.1 PRTN3 MPO COL4A3 ALB
3 goodpasture syndrome 30.1 PRTN3 MPO EDA COL4A5 COL4A4 COL4A3
4 kidney disease 29.4 PRTN3 COL4A5 COL4A4 COL4A3 ALB
5 immune-complex glomerulonephritis 29.4 MPO CFHR2 CD4 ALB
6 glomerulonephritis 28.1 PRTN3 MPO MIF COL4A5 COL4A4 COL4A3
7 vernal conjunctivitis 10.4 MPO CCR6
8 multiple cranial nerve palsy 10.3 PRTN3 MPO
9 alport syndrome 3, autosomal dominant 10.3 COL4A4 COL4A3
10 anca-associated vasculitis 10.3 PRTN3 MPO
11 alport syndrome 2, autosomal recessive 10.3 COL4A4 COL4A3
12 cicatricial entropion 10.3 PRTN3 MPO
13 subleukemic leukemia 10.3 MPO EDA
14 aortitis 10.3 PRTN3 MPO
15 subacute bacterial endocarditis 10.3 PRTN3 MPO
16 digenic disease 10.3 COL4A5 COL4A3
17 maxillary sinusitis 10.3 PRTN3 MPO
18 chondromalacia 10.3 PRTN3 MPO
19 progressive relapsing multiple sclerosis 10.3 CFHR2 CCR6
20 yellow nail syndrome 10.3 CCR6 ALB
21 membranous nephropathy 10.3
22 crescentic glomerulonephritis 10.3
23 klebsiella pneumonia 10.3 CCR6 ALB
24 scleritis 10.2 PRTN3 CCR6
25 toxic megacolon 10.2 CCR6 ALB
26 alport syndrome 1, x-linked 10.2 COL4A5 COL4A4
27 mononeuropathy 10.2 PRTN3 MPO
28 pyuria 10.2 PRTN3 ALB
29 henoch-schoenlein purpura 10.2 PRTN3 MPO CFHR2
30 mediastinitis 10.2 MPO ALB
31 acute poststreptococcal glomerulonephritis 10.2 CFHR2 ALB
32 diffuse cutaneous systemic sclerosis 10.2 MIF CCR6
33 hemorrhagic disease 10.2 PRTN3 MPO CFHR2
34 pasteurellosis 10.2 MPO ALB
35 clostridium difficile colitis 10.2 CCR6 ALB
36 reactive arthritis 10.1 PRTN3 MPO CCR6
37 hydrops, lactic acidosis, and sideroblastic anemia 10.1 MPO ALB
38 pernicious anemia 10.1
39 proteasome-associated autoinflammatory syndrome 1 10.1
40 deficiency anemia 10.1
41 primary biliary cirrhosis 10.1
42 hypothyroidism 10.1
43 liver cirrhosis 10.1
44 chronic kidney disease 10.1
45 obsolete: rapidly progressive glomerulonephritis 10.1
46 iga glomerulonephritis 10.1 CFHR2 CCR6 ALB
47 ureteral disease 10.1 EDA CCR6 ALB
48 autoimmune disease 10.1
49 acute kidney failure 10.1
50 suppurative lymphadenitis 10.1 CD4 CCR6

Graphical network of the top 20 diseases related to Anti-Basement Membrane Glomerulonephritis:



Diseases related to Anti-Basement Membrane Glomerulonephritis

Symptoms & Phenotypes for Anti-Basement Membrane Glomerulonephritis

MGI Mouse Phenotypes related to Anti-Basement Membrane Glomerulonephritis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 ALB CCR6 CD4 COL4A3 COL4A4 COL4A5

Drugs & Therapeutics for Anti-Basement Membrane Glomerulonephritis

Drugs for Anti-Basement Membrane Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
3 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
4
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
5
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
6
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
7
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
8 Antiemetics Phase 3
9 Methylprednisolone Acetate Phase 3
10 Platelet Aggregation Inhibitors Phase 3
11 Free Radical Scavengers Phase 3
12 Hormone Antagonists Phase 3
13 Antioxidants Phase 3
14 Protective Agents Phase 3
15 Anti-Inflammatory Agents Phase 3
16 Immunosuppressive Agents Phase 3
17 Gastrointestinal Agents Phase 3
18 Neuroprotective Agents Phase 3
19 Autonomic Agents Phase 3
20 glucocorticoids Phase 3
21 Antineoplastic Agents, Hormonal Phase 3
22 Phosphodiesterase Inhibitors Phase 3
23 Radiation-Protective Agents Phase 3
24 Vasodilator Agents Phase 3
25 Hormones Phase 3
26 Immunologic Factors
27 Immunoglobulins
28 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Immunoadsorption in Anti-glomerular Basement Membrane Glomerulonephritis; a Pilot Study Recruiting NCT02765789 Phase 4
2 Clinical Efficacy of Combined Pentoxifylline and Conventional Immunosuppressive Regimens on Patients With Rapidly Progressive Glomerulonephritis Terminated NCT00354198 Phase 3 pentoxifylline;corticosteroids
3 Detection of Anti-glomerular Basement Membrane Antibodies (Anti-GBM): a Promising Biomarker for Lupus Nephritis (LN) Screening in Systemic Lupus Erythematosus (SLE) Patients? Recruiting NCT03664908

Search NIH Clinical Center for Anti-Basement Membrane Glomerulonephritis

Genetic Tests for Anti-Basement Membrane Glomerulonephritis

Anatomical Context for Anti-Basement Membrane Glomerulonephritis

MalaCards organs/tissues related to Anti-Basement Membrane Glomerulonephritis:

40
Kidney, T Cells, Lymph Node, Eye, Bone, B Cells, Endothelial

Publications for Anti-Basement Membrane Glomerulonephritis

Articles related to Anti-Basement Membrane Glomerulonephritis:

(show top 50) (show all 128)
# Title Authors PMID Year
1
A Modified Peptide Derived from Goodpasture Autoantigen Arrested and Attenuated Kidney Injuries in a Rat Model of Anti-GBM Glomerulonephritis. 61
31666297 2020
2
Group 1 innate lymphoid cells are involved in the progression of experimental anti-glomerular basement membrane glomerulonephritis and are regulated by peroxisome proliferator-activated receptor α. 61
31402171 2019
3
HLA-DR15-specific inhibition attenuates autoreactivity to the Goodpasture antigen. 61
31104947 2019
4
Antineutrophil cytoplasmic antibody and/or antiglomerular basement membrane antibody associated crescentic glomerulonephritis in combination with IgG4-related tubulointerstitial nephritis. 61
30183608 2019
5
Monotypic IgG1-kappa Atypical Anti-Glomerular Basement Membrane Nephritis: A Case Report. 61
31019927 2019
6
Development of anti-glomerular basement membrane glomerulonephritis during the course of IgA nephropathy: a case report. 61
30683055 2019
7
Falsely positive anti-glomerular basement membrane antibodies in a patient with hantavirus induced acute kidney injury - a case report. 61
30348108 2018
8
Genotype and Outcome After Kidney Transplantation in Alport Syndrome. 61
29854973 2018
9
Matrix metalloproteinase-12 deficiency attenuates experimental crescentic anti-glomerular basement membrane glomerulonephritis. 61
27862656 2018
10
Predicting Outcome in Patients with Anti-GBM Glomerulonephritis. 61
29162595 2018
11
(5R)-5-hydroxytriptolide ameliorates anti-glomerular basement membrane glomerulonephritis in NZW mice by regulating Fcγ receptor signaling. 61
28880016 2018
12
CTGF in kidney fibrosis and glomerulonephritis. 61
30123390 2018
13
ID3 may protect mice from anti‑GBM glomerulonephritis by regulating the differentiation of Th17 and Treg cells. 61
28990057 2017
14
Coexistence of Anti-Glomerular Basement Membrane Glomerulonephritis and Membranous Nephropathy in a Female Patient with Preserved Renal Function. 61
29269610 2017
15
Immunoadsorption in Anti-GBM Glomerulonephritis: Case Report in a Child and Literature Review. 61
29054981 2017
16
The pathogenicity of T cell epitopes on human Goodpasture antigen and its critical amino acid motif. 61
28296059 2017
17
Therapeutic effects and mechanism of conditioned media from human mesenchymal stem cells on anti-GBM glomerulonephritis in WKY rats. 61
27053690 2016
18
Aliskiren Regulates Neonatal Fc Receptor and IgG Metabolism with Attenuation of Anti-GBM Glomerulonephritis in Mice. 61
27560625 2016
19
Suppression of Rapidly Progressive Mouse Glomerulonephritis with the Non-Steroidal Mineralocorticoid Receptor Antagonist BR-4628. 61
26700873 2015
20
A case of antiglomerular basement membrane glomerulonephritis complicated by membranous nephropathy. 61
28509257 2014
21
Galectin-9 ameliorates anti-GBM glomerulonephritis by inhibiting Th1 and Th17 immune responses in mice. 61
24477688 2014
22
Suppression of experimental autoimmune glomerulonephritis by tryptophan. 61
24519862 2014
23
Identical twins:one with anti-glomerular basement membrane glomerulonephritis,the other with systemic lupus erythematosus. 61
24359316 2013
24
A case of anti-GBM glomerulonephritis superimposed on HBV-associated membranous nephropathy. 61
28509304 2013
25
Urinary cystatin C as a renal biomarker and its immunohistochemical localization in anti-GBM glomerulonephritis rats. 61
23791361 2013
26
MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation. 61
22419694 2012
27
Anti-glomerular basement membrane glomerulonephritis complicated by thrombocytopenia. 61
23257527 2012
28
[A case of anti-GBM glomerulonephritis and membranous nephropathy in a patient with primary biliary cirrhosis]. 61
24236349 2012
29
Tubular deficiency of von Hippel-Lindau attenuates renal disease progression in anti-GBM glomerulonephritis. 61
21925138 2011
30
c-fms blockade reverses glomerular macrophage infiltration and halts development of crescentic anti-GBM glomerulonephritis in the rat. 61
21519331 2011
31
Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1. 61
22046355 2011
32
Lack of collagen XVIII/endostatin exacerbates immune-mediated glomerulonephritis. 61
20616167 2010
33
Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis. 61
20660402 2010
34
Both complement and IgG fc receptors are required for development of attenuated antiglomerular basement membrane nephritis in mice. 61
19710463 2009
35
Invariant natural killer T cells and TGF-beta attenuate anti-GBM glomerulonephritis. 61
19470687 2009
36
IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen. 61
19357249 2009
37
Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat. 61
19188913 2009
38
Loss of a renal graft due to recurrence of anti-GBM disease despite rituximab therapy. 61
19087095 2009
39
[Anti-GBM glomerulonephritis and RPGN]. 61
19378793 2009
40
Differential effects of rapamycin in anti-GBM glomerulonephritis. 61
18480312 2008
41
Spontaneous recovery from early glomerular inflammation is associated with resistance to anti-GBM glomerulonephritis: tolerance and autoimmune tissue injury. 61
18054199 2008
42
Inhibition of proinflammatory genes in anti-GBM glomerulonephritis by targeted dexamethasone-loaded AbEsel liposomes. 61
18160627 2008
43
Role of macrophage migration inhibition factor in kidney disease. 61
18663334 2008
44
Histamine ameliorates anti-glomerular basement membrane antibody-induced glomerulonephritis in rats. 61
17568783 2007
45
A pathogenic role for JNK signaling in experimental anti-GBM glomerulonephritis. 61
17597698 2007
46
Inhibition of CXCL16 attenuates inflammatory and progressive phases of anti-glomerular basement membrane antibody-associated glomerulonephritis. 61
17456756 2007
47
Patient with antibody-negative relapse of Goodpasture syndrome. 61
17474560 2007
48
Sequential development of pulmonary renal syndrome associated with c-ANCA 3 years after development of anti-GBM glomerulonephritis. 61
17210587 2007
49
Autoepitopes and alloepitopes of type IV collagen: role in the molecular pathogenesis of anti-GBM antibody glomerulonephritis. 61
17570938 2007
50
Concurrent anti-glomerular basement membrane disease and membranous glomerulonephritis: a case report and literature review. 61
16939068 2006

Variations for Anti-Basement Membrane Glomerulonephritis

Expression for Anti-Basement Membrane Glomerulonephritis

Search GEO for disease gene expression data for Anti-Basement Membrane Glomerulonephritis.

Pathways for Anti-Basement Membrane Glomerulonephritis

GO Terms for Anti-Basement Membrane Glomerulonephritis

Cellular components related to Anti-Basement Membrane Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 PRTN3 MPO MIF EDA COL4A5 COL4A4
2 extracellular space GO:0005615 9.87 PRTN3 MPO MIF COL4A5 COL4A4 COL4A3
3 collagen-containing extracellular matrix GO:0062023 9.71 PRTN3 COL4A5 COL4A4 COL4A3
4 endoplasmic reticulum lumen GO:0005788 9.55 COL4A5 COL4A4 COL4A3 CD4 ALB
5 basement membrane GO:0005604 9.54 COL4A5 COL4A4 COL4A3
6 collagen trimer GO:0005581 9.26 EDA COL4A5 COL4A4 COL4A3
7 collagen type IV trimer GO:0005587 8.8 COL4A5 COL4A4 COL4A3

Biological processes related to Anti-Basement Membrane Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glomerular basement membrane development GO:0032836 8.96 COL4A4 COL4A3
2 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 8.8 COL4A5 COL4A4 COL4A3

Molecular functions related to Anti-Basement Membrane Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.46 PRTN3 MIF EDA CD4
2 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.13 COL4A5 COL4A4 COL4A3
3 extracellular matrix structural constituent GO:0005201 8.92 COL4A5 COL4A4 COL4A3 CD4

Sources for Anti-Basement Membrane Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
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43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
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50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
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70 Tocris
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72 UMLS via Orphanet
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