MCID: ANT089
MIFTS: 12

Anti-Pit-1 Antibody Syndrome

Categories: Immune diseases, Rare diseases

Aliases & Classifications for Anti-Pit-1 Antibody Syndrome

MalaCards integrated aliases for Anti-Pit-1 Antibody Syndrome:

Name: Anti-Pit-1 Antibody Syndrome 52 71

Classifications:



External Ids:

UMLS 71 C4046049

Summaries for Anti-Pit-1 Antibody Syndrome

MalaCards based summary : Anti-Pit-1 Antibody Syndrome is related to alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity and autoimmune disease. An important gene associated with Anti-Pit-1 Antibody Syndrome is POU1F1 (POU Class 1 Homeobox 1). Affiliated tissues include pituitary and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Anti-Pit-1 Antibody Syndrome

Diseases related to Anti-Pit-1 Antibody Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.5
2 autoimmune disease 10.3
3 combined pituitary hormone deficiency 10.3
4 thymoma, familial 10.1
5 thymoma 10.1
6 hypopituitarism 10.1

Graphical network of the top 20 diseases related to Anti-Pit-1 Antibody Syndrome:



Diseases related to Anti-Pit-1 Antibody Syndrome

Symptoms & Phenotypes for Anti-Pit-1 Antibody Syndrome

GenomeRNAi Phenotypes related to Anti-Pit-1 Antibody Syndrome according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.53 SIAE
2 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.53 POU1F1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.53 POU1F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.53 POU1F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.53 POU1F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.53 SIAE
7 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.53 SIAE
8 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.53 POU1F1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-191 9.53 POU1F1 SIAE
10 Increased shRNA abundance (Z-score > 2) GR00366-A-211 9.53 POU1F1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.53 POU1F1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.53 SIAE
13 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.53 POU1F1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.53 SIAE
15 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.53 POU1F1

Drugs & Therapeutics for Anti-Pit-1 Antibody Syndrome

Search Clinical Trials , NIH Clinical Center for Anti-Pit-1 Antibody Syndrome

Genetic Tests for Anti-Pit-1 Antibody Syndrome

Anatomical Context for Anti-Pit-1 Antibody Syndrome

MalaCards organs/tissues related to Anti-Pit-1 Antibody Syndrome:

40
Pituitary, T Cells

Publications for Anti-Pit-1 Antibody Syndrome

Articles related to Anti-Pit-1 Antibody Syndrome:

(show all 11)
# Title Authors PMID Year
1
Pathogenesis of Anti-PIT-1 Antibody Syndrome: PIT-1 Presentation by HLA Class I on Anterior Pituitary Cells. 61
31620667 2019
2
Autoimmune pituitary disease: New concepts with clinical implications. 61
31513261 2019
3
A novel thymoma-associated autoimmune disease: Anti-PIT-1 antibody syndrome. 61
28216655 2017
4
A Novel Clinical Entity of Autoimmune Endocrinopathy: Anti-PIT-1 Antibody Syndrome. 61
28245453 2017
5
Review on Recent Topics in Hypophysitis. 61
29142180 2017
6
[A Novel Clinical Entity "Anti-PIT-1 Antibody Syndrome"--Autoimmunity against a Transcription Factor]. 61
26536783 2015
7
Anti-PIT-1 antibody syndrome; a novel clinical entity leading to hypopituitarism. 61
25962206 2015
8
Involvement of PIT-1-reactive cytotoxic T lymphocytes in anti-PIT-1 antibody syndrome. 61
24937538 2014
9
Autoimmune hypophysitis: new developments. 61
25248604 2014
10
A missense single-nucleotide polymorphism in the sialic acid acetylesterase (SIAE) gene is associated with anti-PIT-1 antibody syndrome. 61
24748456 2014
11
Adult combined GH, prolactin, and TSH deficiency associated with circulating PIT-1 antibody in humans. 61
21123951 2011

Variations for Anti-Pit-1 Antibody Syndrome

Expression for Anti-Pit-1 Antibody Syndrome

Search GEO for disease gene expression data for Anti-Pit-1 Antibody Syndrome.

Pathways for Anti-Pit-1 Antibody Syndrome

GO Terms for Anti-Pit-1 Antibody Syndrome

Sources for Anti-Pit-1 Antibody Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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