MCID: ANT078
MIFTS: 24

Antipyrine Metabolism

Categories: Metabolic diseases

Aliases & Classifications for Antipyrine Metabolism

MalaCards integrated aliases for Antipyrine Metabolism:

Name: Antipyrine Metabolism 56 71

Classifications:



External Ids:

OMIM 56 107290
UMLS 71 C1862824

Summaries for Antipyrine Metabolism

MalaCards based summary : Antipyrine Metabolism is related to liver cirrhosis and liver disease. An important gene associated with Antipyrine Metabolism is ALB (Albumin), and among its related pathways/superpathways are Folate Metabolism and FOXA2 and FOXA3 transcription factor networks. Affiliated tissues include liver, heart and lung.

More information from OMIM: 107290

Related Diseases for Antipyrine Metabolism

Diseases related to Antipyrine Metabolism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
# Related Disease Score Top Affiliating Genes
1 liver cirrhosis 29.8 F2 ALB
2 liver disease 29.6 F2 ALB
3 alcoholic liver cirrhosis 29.6 F2 ALB
4 viral hepatitis 29.5 F2 ALB
5 cholestasis 29.4 F2 ALB
6 lung cancer 10.1
7 diabetes mellitus 10.1
8 47,xyy 10.1
9 48,xyyy 10.1
10 aryl hydrocarbon hydroxylase inducibility 9.9
11 colorectal cancer 9.9
12 polycystic liver disease 1 with or without kidney cysts 9.9
13 hemochromatosis, type 1 9.9
14 gallbladder disease 1 9.9
15 endometrial cancer 9.9
16 gastric cancer 9.9
17 polycystic liver disease 9.9
18 limb ischemia 9.9
19 non-alcoholic steatohepatitis 9.9
20 cholelithiasis 9.9
21 bacterial infectious disease 9.9
22 porphyria 9.9
23 alcohol use disorder 9.9
24 iron metabolism disease 9.9
25 pulmonary tuberculosis 9.9
26 testicular cancer 9.9
27 fascioliasis 9.9
28 encephalopathy 9.9
29 hypoxia 9.9
30 non-a-e hepatitis 9.9 F2 ALB
31 fournier gangrene 9.9 F2 ALB
32 necrotizing gastritis 9.9 F2 ALB
33 hepatic infarction 9.9 F2 ALB
34 hepatic tuberculosis 9.9 F2 ALB
35 splenic abscess 9.9 F2 ALB
36 ascending cholangitis 9.9 F2 ALB
37 cholangitis 9.9 F2 ALB
38 acalculous cholecystitis 9.9 F2 ALB
39 cholecystitis 9.9 F2 ALB
40 hypertensive encephalopathy 9.9 F2 ALB
41 infantile liver failure syndrome 1 9.9 F2 ALB
42 mediastinitis 9.9 F2 ALB
43 acute cholangitis 9.9 F2 ALB
44 abdominal tuberculosis 9.9 F2 ALB
45 paralytic ileus 9.9 F2 ALB
46 hepatic coma 9.9 F2 ALB
47 active peptic ulcer disease 9.9 F2 ALB
48 common bile duct disease 9.9 F2 ALB
49 bile duct disease 9.9 F2 ALB
50 kwashiorkor 9.9 F2 ALB

Graphical network of the top 20 diseases related to Antipyrine Metabolism:



Diseases related to Antipyrine Metabolism

Symptoms & Phenotypes for Antipyrine Metabolism

Clinical features from OMIM:

107290

Drugs & Therapeutics for Antipyrine Metabolism

Search Clinical Trials , NIH Clinical Center for Antipyrine Metabolism

Genetic Tests for Antipyrine Metabolism

Anatomical Context for Antipyrine Metabolism

MalaCards organs/tissues related to Antipyrine Metabolism:

40
Liver, Heart, Lung, Kidney, Thyroid, Testes, Brain

Publications for Antipyrine Metabolism

Articles related to Antipyrine Metabolism:

(show top 50) (show all 217)
# Title Authors PMID Year
1
Antipyrine metabolism in the rat by three hepatic monooxygenases. 61 56
7401910 1980
2
Monogenic control of variations in antipyrine metabolite formation. New polymorphism of hepatic drug oxidation. 56
6863539 1983
3
Genetic variation in rates of antipyrine metabolite formation: a study in uninduced twins. 56
6946467 1981
4
Studies on the different metabolic pathways of antipyrine in rats: influence of phenobarbital and 3-methylcholanthrene treatment. 56
119355 1979
5
Impact of dioxins on antipyrine metabolism in firefighters. 61
27067104 2016
6
Role of cytochrome P450-dependent monooxygenases and polymorphic variants of GSTT1 and GSTM1 genes in the formation of brain lesions in individuals chronically exposed to mercury. 61
24319713 2013
7
Predicting and managing adverse reactions of psychotropic drugs. 61
23796468 2013
8
Mild hepatitis at recommended doses of acetaminophen in patients with evidence of constitutionally enhanced cytochrome P450 system activity. 61
18452419 2008
9
Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure. 61
12698250 2003
10
Inmunoferon, an immunomodulator of natural origin, does not affect the rat liver cytochrome P-450 and phase II conjugation enzymes. 61
12743622 2003
11
Influence of nifedipine, nitrendipine and verapamil at low concentration on antipyrine metabolism examined by extracorporeal rat liver perfusion. 61
12926547 2003
12
Transarterial chemoembolization (TACE) for unresectable hepatocellular carcinoma in cirrhotics: functional hepatic reserve and survival. 61
12630024 2003
13
Diabetes and elimination of antipyrine in man: an analysis of 298 patients classified by type of diabetes, age, sex, duration of disease and liver involvement. 61
12071338 2002
14
Induction of hepatic and presystemic metabolism of antipyrine in the mice: rifampicin versus rifabutin. 61
11808861 2001
15
Urine antipyrine metabolites in rats with different resistance to hypoxia subjected to cold stress. 61
11427903 2001
16
Effect of experimental fasciolosis on antipyrine metabolism and clearance in water buffaloes. 61
10714456 2000
17
Evaluation of the influence of diabetes mellitus on antipyrine metabolism and CYP1A2 and CYP2D6 activity. 61
10678296 2000
18
Direct detection of antipyrine metabolites in rat urine by (13)C labeling and NMR spectroscopy. 61
10534308 1999
19
The effect of sex on antipyrine metabolism in cattle at different ages. 61
10447826 1999
20
[The effect of reversible ischemia of the rat liver on antipyrine metabolism and the isoenzyme activity of cytochrome P-450]. 61
10198766 1999
21
Plasma levels of fibronectin in patients with chronic viral and alcoholic liver disease. 61
9840137 1998
22
Antipyrine clearance in chronic and neoplastic liver diseases: a study of 518 patients. 61
9641640 1998
23
Factors that influence microdialysis recovery. Comparison of experimental and theoretical microdialysis recoveries in rat liver. 61
9269875 1997
24
The effect of velnacrine on the mixed function oxidase system. 61
9248779 1997
25
The effect of cimetidine on antipyrine metabolism in calves. 61
9049953 1997
26
Antipyrine metabolism in lung cancer patients and their relatives. 61
9337547 1997
27
Oxamniquine inhibits metabolism of caffeine, hexobarbitone and antipyrine in vivo in mice. 61
17451311 1996
28
Effect of alcohol abuse and glutathione administration on the circulating levels of glutathione and on antipyrine metabolism in patients with alcoholic liver cirrhosis. 61
8869667 1996
29
Effect of spironolactone on antipyrine metabolism in calves. 61
8819201 1996
30
Influence of nutrition on liver oxidative metabolism. 61
8875541 1996
31
Experimental ovine fasciolosis: antipyrine clearance as indicator of liver damage. 61
8638398 1996
32
Absence of hepatic enzyme induction in prostate cancer patients receiving 'Casodex' (bicalutamide). 61
8742099 1996
33
[Initial prospective evaluation of cancer incidence in relation to metabolism of antipyrine and family history in patients with lung cancer]. 61
8630464 1996
34
Relationship between antipyrine metabolism and acetylation phenotype in health and chronic liver diseases. 61
7665722 1995
35
Antipyrine repeatability and comparison of the powder and capsule formulations. 61
7757313 1995
36
Antipyrine Metabolism during Chemotherapy with 5-Fluorouracil Plus Folinic Acid in Patients with Liver Metastases from Primary Colorectal Cancer. 61
11835096 1994
37
Elimination of antipyrine and its metabolites in interferon treated hepatitis C. 61
7986571 1994
38
Performance of plasma-perfused, microencapsulated hepatocytes: prospects for extracorporeal liver support. 61
8301453 1993
39
Metabolism of antipyrine in vivo in two rat models of liver cirrhosis. Its relationship to intrinsic clearance in vitro and microsomal membrane lipid composition. 61
8216358 1993
40
Inhibitory action of cimetidine on antipyrine metabolism. 61
8118484 1993
41
Determination of antipyrine sulphoconjugates in isolated cultured rat hepatocytes. 61
8498081 1993
42
Antipyrine elimination in patients with alcoholic and non-alcoholic cirrhosis. 61
8447150 1993
43
[Antipyrine metabolism in lung cancer patients]. 61
8111326 1993
44
Solid phase extraction and simultaneous high performance liquid chromatographic determination of antipyrine and its major metabolites in urine. 61
1286289 1992
45
Antipyrine metabolism in patients with liver metastases from colorectal cancer. 61
1515999 1992
46
Clinical pharmacokinetics of calcium antagonists. An update. 61
1587055 1992
47
Drug metabolism in rats with cancer induced by N-nitrosodiethylamine and phenobarbital. 61
1438025 1992
48
[Antipyrine metabolism and rat liver ultrastructure in single and combined action of trichlorodiphenyl and dioctyl phthalate]. 61
1421228 1992
49
[The rate of antipyrine metabolism in cancer patients administered specific therapy]. 61
1343156 1992
50
Non-alcoholic steatohepatitis: impaired antipyrine metabolism and hypertriglyceridaemia may be clues to its pathogenesis. 61
1782374 1991

Variations for Antipyrine Metabolism

Expression for Antipyrine Metabolism

Search GEO for disease gene expression data for Antipyrine Metabolism.

Pathways for Antipyrine Metabolism

Pathways related to Antipyrine Metabolism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.29 F2 ALB
2 10.27 F2 ALB

GO Terms for Antipyrine Metabolism

Cellular components related to Antipyrine Metabolism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 8.96 F2 ALB
2 blood microparticle GO:0072562 8.62 F2 ALB

Biological processes related to Antipyrine Metabolism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 8.62 F2 ALB

Sources for Antipyrine Metabolism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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