MCID: ANT011
MIFTS: 47

Antisocial Personality Disorder

Categories: Mental diseases

Aliases & Classifications for Antisocial Personality Disorder

MalaCards integrated aliases for Antisocial Personality Disorder:

Name: Antisocial Personality Disorder 12 75 55 44 15 72
Dissocial Personality Disorder 12 33
Psychopathic Personality Disorder 12
Psychopathic Personality 12
Sociopathic Personality 12
Psychopath.personality 12
Asocial Personality 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10939
ICD9CM 35 301.7
MeSH 44 D000987
NCIt 50 C88413
SNOMED-CT 68 26665006
ICD10 33 F60.2
UMLS 72 C0003431

Summaries for Antisocial Personality Disorder

Disease Ontology : 12 A personality disorder that involves a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood.

MalaCards based summary : Antisocial Personality Disorder, also known as dissocial personality disorder, is related to impulse control disorder and avoidant personality disorder. An important gene associated with Antisocial Personality Disorder is MAOA (Monoamine Oxidase A), and among its related pathways/superpathways are Circadian entrainment and Transmission across Chemical Synapses. The drugs Dopamine and Methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and cortex, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 75 Antisocial personality disorder (ASPD or APD) is a personality disorder characterized by a long term... more...

Related Diseases for Antisocial Personality Disorder

Diseases related to Antisocial Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 impulse control disorder 32.5 DRD2 ANKK1
2 avoidant personality disorder 32.2 SLC6A4 MAOA
3 dysthymic disorder 31.0 SLC6A4 MAOA
4 cocaine dependence 31.0 SLC6A4 SLC6A3 DRD2
5 conduct disorder 30.9 SLC6A4 SLC6A3 MAOA DRD2 COMT ALDH2
6 tic disorder 30.8 SLC6A3 DRD2
7 drug dependence 30.7 SLC6A4 DRD2 ANKK1
8 heroin dependence 30.7 DRD2 ANKK1
9 social phobia 30.6 SLC6A4 MAOA DRD2
10 opiate dependence 30.6 SLC6A4 DRD2
11 cocaine abuse 30.5 SLC6A4 SLC6A3 DRD2
12 anxiety 30.4 SLC6A4 MAOA COMT
13 mental depression 30.2 SLC6A4 MAOA COMT
14 borderline personality disorder 30.1 SLC6A4 MAOA HTR1B COMT
15 substance dependence 30.0 SLC6A4 SLC6A3 MAOA HTR1B DRD2
16 polysubstance abuse 30.0 DRD2 COMT
17 generalized anxiety disorder 29.9 SLC6A4 MAOA DRD2 COMT
18 panic disorder 29.7 SLC6A4 MAOA COMT
19 bipolar disorder 29.7 SLC6A4 SLC6A3 DRD2 COMT
20 schizoaffective disorder 29.6 SLC6A4 DRD2 COMT
21 pathological gambling 29.6 SLC6A4 SLC6A3 MAOB MAOA DRD2
22 bulimia nervosa 29.4 SLC6A4 HTR1B COMT
23 substance abuse 29.3 SLC6A4 SLC6A3 MAOA HTR1B DRD2 COMT
24 alexithymia 29.3 SLC6A4 DRD2 COMT ANKK1
25 oppositional defiant disorder 29.2 SLC6A4 SLC6A3 MAOA DRD2 COMT
26 personality disorder 29.0 SLC6A4 SLC6A3 MAOA HTR1B DRD2 COMT
27 disease of mental health 29.0 SLC6A4 SLC6A3 MAOA DRD2 COMT
28 post-traumatic stress disorder 28.8 SLC6A4 MAOB MAOA DRD2 COMT
29 psychotic disorder 28.6 SLC6A4 SLC6A3 MAOB DRD2 COMT
30 major depressive disorder 28.4 SLC6A4 SLC6A3 MAOA HTR1B DRD2 COMT
31 brunner syndrome 28.2 SLC6A4 MAOB MAOA HTR1B COMT
32 mood disorder 27.7 SLC6A4 MAOB MAOA HTR1B DRD2 COMT
33 alcohol dependence 27.4 SLC6A4 SLC6A3 MAOB MAOA HTR1B DRD2
34 schizophrenia 27.0 SNAP25 SLC6A4 SLC6A3 MAOB MAOA HTR1B
35 attention deficit-hyperactivity disorder 26.6 SNAP25 SLC6A4 SLC6A3 MAOB MAOA HTR1B
36 severe combined immunodeficiency 10.7
37 kleptomania 10.5 SLC6A4 MAOA
38 alcohol use disorder 10.5
39 agoraphobia 10.5 SLC6A4 MAOA
40 periodic limb movement disorder 10.4 SLC6A4 DRD2
41 striatonigral degeneration 10.4 SLC6A3 DRD2
42 major affective disorder 8 10.3
43 major affective disorder 9 10.3
44 depression 10.3
45 somatization disorder 10.3
46 taqi polymorphism 10.3 DRD2 ANKK1
47 stuttering 10.2 SLC6A3 DRD2
48 histrionic personality disorder 10.2
49 acute stress disorder 10.2
50 exhibitionism 10.2 MAOB MAOA

Comorbidity relations with Antisocial Personality Disorder via Phenotypic Disease Network (PDN):


Schizophreniform Disorder

Graphical network of the top 20 diseases related to Antisocial Personality Disorder:



Diseases related to Antisocial Personality Disorder

Symptoms & Phenotypes for Antisocial Personality Disorder

MGI Mouse Phenotypes related to Antisocial Personality Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.13 ALDH2 COL25A1 COMT DRD2 HTR1B MAOA
2 homeostasis/metabolism MP:0005376 9.97 ALDH2 COL25A1 COMT DRD2 MAOA MAOB
3 cardiovascular system MP:0005385 9.95 ALDH2 COMT DRD2 HTR1B MAOA SLC6A4
4 endocrine/exocrine gland MP:0005379 9.91 ALDH2 COMT DRD2 HTR1B SLC6A3 SLC6A4
5 nervous system MP:0003631 9.81 ALDH2 COL25A1 COMT DRD2 MAOA MAOB
6 muscle MP:0005369 9.8 ALDH2 COL25A1 DRD2 HTR1B SLC6A3 SLC6A4
7 reproductive system MP:0005389 9.43 ALDH2 COMT DRD2 HTR1B SLC6A3 SNAP25
8 taste/olfaction MP:0005394 8.8 DRD2 SLC6A3 SNAP25

Drugs & Therapeutics for Antisocial Personality Disorder

Drugs for Antisocial Personality Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
3
Naratriptan Approved, Investigational Phase 4 121679-13-8, 143388-64-1 4440
4 Central Nervous System Stimulants Phase 4
5 Dopamine Agents Phase 4
6 Neurotransmitter Uptake Inhibitors Phase 4
7 Dopamine Uptake Inhibitors Phase 4
8 Neurotransmitter Agents Phase 4
9 Vasoconstrictor Agents Phase 4
10 Serotonin Receptor Agonists Phase 4
11 Serotonin 5-HT1 Receptor Agonists Phase 4
12 Serotonin Agents Phase 4
13
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
14
Leuprolide Approved, Investigational Phase 2, Phase 3 53714-56-0 3911 657181
15
Pomegranate Experimental, Investigational Phase 2, Phase 3
16 Fertility Agents Phase 2, Phase 3
17 Antineoplastic Agents, Hormonal Phase 2, Phase 3
18 Omega 3 Fatty Acid Phase 2, Phase 3
19 Antioxidants Phase 2, Phase 3
20 Coagulants Phase 1
21 Natriuretic Agents Phase 1
22 Hemostatics Phase 1
23 Arginine Vasopressin Phase 1
24 arginine Phase 1
25 Vasopressins Phase 1
26
Cocaine Approved, Illicit 50-36-2 446220 5760
27
Morphine Approved, Investigational 57-27-2 5288826
28
Ethanol Approved 64-17-5 702
29 Anti-Infective Agents
30 Antiviral Agents
31 Lisdexamfetamine Dimesylate
32 Anesthetics, Local
33 Peripheral Nervous System Agents
34 Central Nervous System Depressants
35 Anesthetics

Interventional clinical trials:

(show all 34)
# Name Status NCT ID Phase Drugs
1 Multimodal Treatment Study of Children With ADHD Completed NCT00000388 Phase 4 Anti-ADHD medication
2 Effects of Expectation, Medication and Placebo on Objective and Self-rated Performance During the Quantified Behavior Test in Patients With Untreated ADHD Completed NCT02473185 Phase 4 Methylphenidate
3 Effects of Expectation, Medication and Placebo on Objective and Self-rated Performance During the Quantified Behavior Test in Patients With Untreated ADHD and Substance Use Disorder Recruiting NCT02477280 Phase 4 Methylphenidate;Placebo
4 Efficacy of a Triptan in the Treatment of Hostility and Aggression Among Convicts With a Psychiatric Treatment Order Terminated NCT00282165 Phase 4 naratriptan;placebo
5 Leuprolide Acetate Suppresses Pedophilic Urges and Arousability Unknown status NCT00220350 Phase 2, Phase 3 leuprolide acetate
6 Omega-3 Supplements to Reduce Antisocial Behaviour in Young Offenders: A Randomized Controlled Trial Completed NCT03627312 Phase 2, Phase 3
7 Omega-3 Supplementation and Behavior Problems in Children and Adolescents Completed NCT02334098 Phase 2, Phase 3
8 Computerized Working Memory Training in Adults With Substance Abuse and Executive Function Deficits: A Randomised Controlled Trial. Unknown status NCT02068261 Phase 2
9 The Impact of Psychopathic Traits on the Efficacy of a Brief Intervention for Substance Use Completed NCT01532934 Phase 2
10 Phase 2 Study of Vasopressin Effects on Human Social Communication Completed NCT01327027 Phase 1 Vasopressin, Arginine, ADH;Placebo; Sterile Saline
11 Psychosocial Risk- and Protective Factors of Secondary School Dropout in Luxembourg: an Exploratory Case-control Study Unknown status NCT01354236
12 Intergenerational Transmission of Antisocial Behavior Unknown status NCT00060788
13 An Investigation of Cognitive Functioning and Brain Metabolites in Patients With Non-Cirrhotic Hepatitis-C Both Pre- and Post-Treatment With Antiviral Medication Unknown status NCT00188201
14 Passage à l'Acte en Maison d'arrêt : Recherche d'éléments Contextuels récurrents Prospectifs et rétrospectifs Completed NCT02493088
15 Early Exposure to Lead and Adult Antisocial Outcomes Completed NCT00285610
16 Matching Cognitive Remediation to Cognitive Deficits in Substance-Abusing Inmates Completed NCT01428349
17 Investigation of Psychophysiological Response to Aversive Stimuli Over Time With Omega-3 Completed NCT03749824
18 To Evaluate the Safety and Metabolic Profile of Vyvanse for the Treatment of ADHD in Euthymic Adults With Bipolar I/II Disorder Completed NCT01263548 lisdexamfetamine dimesylate
19 Impaired Decision-making in Adolescents: A Vulnerability Factor for the Development of Substance Use and Abuse. Completed NCT01253993
20 Developing Computer Based Treatments for Addiction Completed NCT00586534
21 Youth Empowerment Solutions for Positive Youth Development (YES) Also Known as Genesee County Afterschool Study (GCAS) Completed NCT01884090
22 Pregnancy Denial and Attachment Completed NCT02867579
23 A Follow-up, Family Study on Attention-deficit Hyperactivity Disorder Completed NCT00417781
24 Testing a Shortened Version of the AlAn's Game, Which Can be Delivered Through REDCap, in a Sample of Emerging Adults Recruiting NCT03834467
25 Effectiveness Trial of Treatment to Reduce Serious Antisocial Behavior in Emerging Adults With Mental Illness Recruiting NCT02922335
26 An 18-Month Psychotherapy of Borderline Personality Disorder Recruiting NCT03329677
27 Treatment of Justice-Involved Emerging Adults With Substance Use Disorders Recruiting NCT03035877
28 The Efficacy of a Compassion Focused Therapy-based Intervention in Detained Youth: A Clinical Trial Active, not recruiting NCT03971682
29 The Effect of Repeated Transcranial Direct Current Stimulation of the Prefrontal Cortex on Antisocial and Aggressive Behavior Active, not recruiting NCT02674516
30 The Effect of Transcranial Direct Current Stimulation of the Prefrontal Cortex on Antisocial and Aggressive Behavior Active, not recruiting NCT02427672
31 Improving Treatment Engagement and Outcomes Among Justice-involved Veterans Active, not recruiting NCT02524171
32 Multisite Prevention of Conduct Problems Active, not recruiting NCT01653535
33 Mentalization Based Treatment - Introductory Group for Male Prisoners With Borderline and/or Antisocial Personality Disorder in Her Majesty's Prison Barlinnie Not yet recruiting NCT04033835
34 Role of Oxytocin in Telling and Detecting Lies Withdrawn NCT02361177 Early Phase 1 Oxytocin

Search NIH Clinical Center for Antisocial Personality Disorder

Cochrane evidence based reviews: antisocial personality disorder

Genetic Tests for Antisocial Personality Disorder

Anatomical Context for Antisocial Personality Disorder

MalaCards organs/tissues related to Antisocial Personality Disorder:

41
Testes, Brain, Cortex, Prefrontal Cortex, Eye, Amygdala, Liver

Publications for Antisocial Personality Disorder

Articles related to Antisocial Personality Disorder:

(show top 50) (show all 1831)
# Title Authors PMID Year
1
Incremental effect for antisocial personality disorder genetic risk combining 5-HTTLPR and 5-HTTVNTR polymorphisms. 9 38
20363030 2010
2
Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder. 9 38
20175604 2010
3
The relationship between serotonin receptor 1B polymorphisms A-161T and alcohol dependence. 9 38
19519719 2009
4
MAOA-uVNTR polymorphism may modify the protective effect of ALDH2 gene against alcohol dependence in antisocial personality disorder. 9 38
19302089 2009
5
Monoamine oxidase A and childhood adversity as risk factors for conduct disorder in females. 9 38
18752729 2009
6
Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women. 9 38
17592478 2008
7
Possible interaction between MAOA and DRD2 genes associated with antisocial alcoholism among Han Chinese men in Taiwan. 9 38
17007976 2007
8
Relationship between dopaminergic neurotransmission, alcoholism, and Reward Deficiency syndrome. 9 38
15457501 2005
9
Analysis of monoamine oxidase A (MAO-A) promoter polymorphism in male heroin-dependent subjects: behavioural and personality correlates. 9 38
15088154 2004
10
The utility of the non-human primate; model for studying gene by environment interactions in behavioral research. 9 38
14653305 2003
11
The A1 allele of the DRD2 gene (TaqI A polymorphisms) is associated with antisocial personality in a sample of alcohol-dependent patients. 9 38
14643564 2003
12
Neither antisocial personality disorder nor antisocial alcoholism is associated with the MAO-A gene in Han Chinese males. 9 38
12824808 2003
13
Impulsive traits and 5-HT2A receptor promoter polymorphism in alcohol dependents: possible association but no influence of personality disorders. 9 38
11287798 2001
14
Dopamine transporter and D2-receptor density in late-onset alcoholism. 9 38
10639691 1999
15
Association of a regulatory polymorphism in the promoter region of the monoamine oxidase A gene with antisocial alcoholism. 9 38
10359483 1999
16
Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations. 9 38
9819067 1998
17
Gender differences in the relationship of antisocial personality disorder criteria to Psychopathy Checklist-Revised scores. 9 38
9573521 1998
18
Childhood sexual abuse is significantly associated with subsequent sexual offending: New evidence among federal correctional clients. 38
31252352 2019
19
CR-19-0950: Event-related responses to alcohol-related stimuli in Mexican-American young adults: Relation to age, gender, comorbidity and "dark side" symptoms. 38
31323376 2019
20
Concepts of mental disorders in the United Kingdom: Similarities and differences between the lay public and psychiatrists. 38
31311429 2019
21
Implications for the Measurement of Psychopathy in the DSM-5 Using the Computerized Adaptive Test of Personality Disorder. 38
29873521 2019
22
Behavioral and electrophysiological responses to fairness norm violations in antisocial offenders. 38
29397410 2019
23
The association between SYT1-rs2251214 and cocaine use disorder further supports its role in psychiatry. 38
31059723 2019
24
Temperament and character in homicidal patients with schizophrenia. 38
31215824 2019
25
Homicidal Ideation and Forensic Psychopathology: Evidence From the 2016 Nationwide Emergency Department Sample (NEDS). 38
31404481 2019
26
Executive function, attention, and memory deficits in antisocial personality disorder and psychopathy. 38
31200194 2019
27
Antisocial Traits, Negative Emotionality, and Trajectories of Relationship Quality in Mexican-Origin Couples. 38
31403390 2019
28
The etiology of antisocial personality disorder: The differential roles of adverse childhood experiences and childhood psychopathology. 38
31079021 2019
29
Differential levels of prefrontal cortex glutamate+glutamine in adults with antisocial personality disorder and bipolar disorder: A proton magnetic resonance spectroscopy study. 38
30959086 2019
30
Sensorimotor Gating in Cocaine-Related Disorder with Comorbid Schizophrenia or Antisocial Personality Disorder. 38
31287382 2019
31
The association between personality disorders/traits and violent eye trauma. 38
30858566 2019
32
Improving characterization of psychopathy within the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), alternative model for personality disorders: Creation and validation of Personality Inventory for DSM-5 Triarchic scales. 38
31259604 2019
33
Rare copy number variation in extremely impulsively violent males. 38
30411505 2019
34
Conduct disorder. 38
31249310 2019
35
Correlates of nicotine dependence in men with childhood attention-deficit/hyperactivity disorder: a 33-year follow-up. 38
30171588 2019
36
Cannabis use, problem-gambling severity, and psychiatric disorders: Data from the national epidemiological survey on alcohol and related conditions. 38
31246071 2019
37
Indirect Effects of Early Parenting on Adult Antisocial Outcomes via Adolescent Conduct Disorder Symptoms and Callous-Unemotional Traits. 38
31166154 2019
38
The risk of assault against mental health professionals: a fatal case report and literature review. 38
31028573 2019
39
Changes in subjective wellbeing of prisoners on remand. 38
31172856 2019
40
Gambling Disorder in Male Violent Offenders in the Prison System: Psychiatric and Substance-Related Comorbidity. 38
29971589 2019
41
Crack users and violence. What is the relationship between trauma, antisocial personality disorder and posttraumatic stress disorder? 38
31233950 2019
42
Psychodynamic art psychotherapy for the treatment of aggression in an individual with antisocial personality disorder in a secure forensic hospital: A single-case design study. 38
31144853 2019
43
Antisocial personality and risks of cause-specific mortality: results from the Epidemiologic Catchment Area study with 27 years of follow-up. 38
30506390 2019
44
Sex differences on the four-facet model of psychopathy predict physical, verbal, and indirect aggression. 38
30699249 2019
45
"I's" on the prize: A systematic review of individual differences in Contingency Management treatment response. 38
30898330 2019
46
Comorbidity Patterns Among Patients With Opioid Use Disorder and Problem Gambling: ADHD Status Predicts Class Membership. 38
30999811 2019
47
Clinical and Personality Characteristics of Problem and Pathological Gamblers With and Without Symptoms of Adult ADHD. 38
30882557 2019
48
N2 amplitude modulation across the antisocial spectrum: a meta-analysis. 38
30954973 2019
49
Post-traumatic stress disorder and having antisocial peers in adolescence are risk factors for the development of antisocial personality disorder. 38
30822743 2019
50
Light and heavy drinking in jurisdictions with different alcohol policy environments. 38
30711804 2019

Variations for Antisocial Personality Disorder

Expression for Antisocial Personality Disorder

Search GEO for disease gene expression data for Antisocial Personality Disorder.

Pathways for Antisocial Personality Disorder

Pathways related to Antisocial Personality Disorder according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.78 SLC6A3 MAOB MAOA DRD2 COMT
2
Show member pathways
12.73 SNAP25 SLC6A4 SLC6A3 MAOA COMT ALDH2
3 11.92 SNAP25 SLC6A4 MAOA
4
Show member pathways
11.74 SLC6A3 MAOB MAOA DRD2
5 11.68 SLC6A4 MAOB MAOA HTR1B
6
Show member pathways
11.65 MAOB MAOA ALDH2
7
Show member pathways
11.43 MAOB MAOA ALDH2
8
Show member pathways
11.29 SLC6A4 SLC6A3 MAOA
9
Show member pathways
11.16 MAOB MAOA ALDH2
10 11.06 SLC6A3 MAOB
11 11.06 SLC6A4 MAOA HTR1B
12
Show member pathways
10.87 MAOA COMT
13 10.58 MAOB MAOA COMT
14
Show member pathways
10.45 MAOB MAOA ALDH2
15
Show member pathways
10.44 SLC6A4 SLC6A3 MAOA COMT ALDH2
16
Show member pathways
10.43 MAOB MAOA COMT ALDH2

GO Terms for Antisocial Personality Disorder

Cellular components related to Antisocial Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.77 SLC6A4 SLC6A3 HTR1B DRD2 COL25A1
2 axon GO:0030424 9.56 SNAP25 SLC6A3 DRD2 COMT
3 integral component of postsynaptic membrane GO:0099055 9.33 SLC6A4 SLC6A3 DRD2
4 dopaminergic synapse GO:0098691 9.32 SLC6A3 DRD2
5 serotonergic synapse GO:0099154 8.96 SLC6A4 HTR1B
6 integral component of presynaptic membrane GO:0099056 8.92 SLC6A4 SLC6A3 HTR1B DRD2

Biological processes related to Antisocial Personality Disorder according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 response to toxic substance GO:0009636 9.71 SLC6A4 MAOB DRD2
2 locomotory behavior GO:0007626 9.69 SNAP25 SLC6A3 DRD2
3 neurotransmitter transport GO:0006836 9.62 SLC6A4 SLC6A3
4 response to nicotine GO:0035094 9.62 SLC6A3 DRD2
5 positive regulation of multicellular organism growth GO:0040018 9.61 SLC6A3 DRD2
6 feeding behavior GO:0007631 9.61 HTR1B DRD2
7 associative learning GO:0008306 9.6 SNAP25 DRD2
8 response to iron ion GO:0010039 9.59 SLC6A3 DRD2
9 vasoconstriction GO:0042310 9.58 SLC6A4 HTR1B
10 prepulse inhibition GO:0060134 9.58 SLC6A3 DRD2
11 dopamine metabolic process GO:0042417 9.57 DRD2 COMT
12 neurotransmitter biosynthetic process GO:0042136 9.56 SLC6A4 SLC6A3
13 response to ethanol GO:0045471 9.56 SLC6A3 MAOB HTR1B DRD2
14 G protein-coupled receptor internalization GO:0002031 9.55 HTR1B DRD2
15 catecholamine metabolic process GO:0006584 9.52 MAOA COMT
16 response to cocaine GO:0042220 9.5 SLC6A3 HTR1B DRD2
17 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.49 HTR1B DRD2
18 monoamine transport GO:0015844 9.48 SLC6A4 SLC6A3
19 adenohypophysis development GO:0021984 9.46 SLC6A3 DRD2
20 neurotransmitter uptake GO:0001504 9.43 SNAP25 SLC6A3
21 response to drug GO:0042493 9.43 SLC6A4 SLC6A3 MAOB HTR1B DRD2 COMT
22 drinking behavior GO:0042756 9.4 HTR1B DRD2
23 negative regulation of serotonin secretion GO:0014063 9.37 MAOB HTR1B
24 neurotransmitter catabolic process GO:0042135 9.33 MAOB MAOA COMT
25 dopamine catabolic process GO:0042420 8.92 SLC6A3 MAOB MAOA COMT

Molecular functions related to Antisocial Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 syntaxin-1 binding GO:0017075 9.4 SNAP25 SLC6A4
2 neurotransmitter:sodium symporter activity GO:0005328 9.37 SLC6A4 SLC6A3
3 dopamine binding GO:0035240 9.32 SLC6A3 DRD2
4 serotonin binding GO:0051378 9.26 SLC6A4 HTR1B
5 monoamine transmembrane transporter activity GO:0008504 9.16 SLC6A4 SLC6A3
6 drug binding GO:0008144 9.13 SLC6A3 HTR1B DRD2
7 primary amine oxidase activity GO:0008131 8.62 MAOB MAOA

Sources for Antisocial Personality Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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