MCID: ANT011
MIFTS: 46

Antisocial Personality Disorder

Categories: Mental diseases

Aliases & Classifications for Antisocial Personality Disorder

MalaCards integrated aliases for Antisocial Personality Disorder:

Name: Antisocial Personality Disorder 12 74 54 43 15 71
Dissocial Personality Disorder 12 32
Psychopathic Personality Disorder 12
Psychopathic Personality 12
Sociopathic Personality 12
Psychopath.personality 12
Asocial Personality 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10939
ICD9CM 34 301.7
MeSH 43 D000987
NCIt 49 C88413
SNOMED-CT 67 26665006
ICD10 32 F60.2
UMLS 71 C0003431

Summaries for Antisocial Personality Disorder

Disease Ontology : 12 A personality disorder that involves a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood.

MalaCards based summary : Antisocial Personality Disorder, also known as dissocial personality disorder, is related to conduct disorder and depression. An important gene associated with Antisocial Personality Disorder is MAOA (Monoamine Oxidase A), and among its related pathways/superpathways are Transmission across Chemical Synapses and Circadian entrainment. The drugs Dopamine and Methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Wikipedia : 74 Antisocial personality disorder (ASPD or APD) is a personality disorder characterized by a long-term... more...

Related Diseases for Antisocial Personality Disorder

Diseases related to Antisocial Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)
# Related Disease Score Top Affiliating Genes
1 conduct disorder 32.2 SLC6A4 SLC6A3 MAOA GABRA2 DRD2 COMT
2 depression 31.1 SLC6A4 MAOA HTR2A
3 somatization disorder 30.9 SLC6A4 HTR2A
4 neurotic disorder 30.8 SLC6A4 MAOA HTR2A
5 polysubstance abuse 30.6 DRD2 COMT
6 generalized anxiety disorder 30.6 SLC6A4 SLC6A3 MAOA HTR2A DRD2 COMT
7 opiate dependence 30.5 SLC6A4 SLC6A3 LOC110806262 DRD2 ANKK1
8 borderline personality disorder 30.5 SLC6A4 SLC6A3 PRL MAOA HTR2A HTR1B
9 drug dependence 30.4 SLC6A4 SLC6A3 GABRA2 DRD2 ANKK1
10 impulse control disorder 30.4 WASF1 SLC6A4 SLC6A3 RTN4 MAOB MAOA
11 alexithymia 30.4 SLC6A4 LOC110806262 DRD2 COMT ANKK1
12 cocaine abuse 30.4 SLC6A4 SLC6A3 PRL MAOB DRD2
13 histrionic personality disorder 30.3 WASF2 WASF1 PIR
14 sexual disorder 30.3 SLC6A4 PRL HTR2A DRD2
15 paranoid personality disorder 30.2 WASF2 WASF1 PIR
16 conversion disorder 30.2 PIR COMT
17 post-traumatic stress disorder 30.1 SLC6A4 MAOB MAOA HTR2A DRD2 COMT
18 cannabis dependence 30.1 WASF1 GABRA2 COMT
19 personality disorder 30.0 SNAP25 SLC6A4 SLC6A3 PRL MAOB MAOA
20 heroin dependence 30.0 SLC6A4 SLC6A3 MAOA DRD2 COMT ANKK1
21 schizoaffective disorder 30.0 SLC6A4 PRL HTR2A DRD2 COMT
22 body dysmorphic disorder 29.9 SLC6A4 RTN4 MAOA HTR2A
23 avoidant personality disorder 29.9 WASF2 WASF1 TTF2 SLC6A4 SLC6A3 PIR
24 narcissistic personality disorder 29.8 WASF2 WASF1 TTF2 PIR
25 schizotypal personality disorder 29.8 WASF2 WASF1 PIR DRD2 COMT
26 brunner syndrome 29.6 TTF2 SLC6A4 MAOB MAOA HTR2A COMT
27 cannabis abuse 29.6 WASF2 WASF1 GABRA2 DRD2 COMT
28 separation anxiety disorder 29.6 WASF2 WASF1 SLC6A4 SLC6A3 RTN4
29 bulimia nervosa 29.6 SLC6A4 PRL MAOA HTR2A HTR1B DRD2
30 dysthymic disorder 29.5 WASF2 WASF1 SLC6A4 PIR MAOA HTR2A
31 cocaine dependence 29.5 SLC6A4 SLC6A3 PRL MAOB HTR2A HTR1B
32 social phobia 29.5 WASF2 WASF1 SLC6A4 PRL MAOA LOC110806262
33 alcohol dependence 29.4 SLC6A4 SLC6A3 PRL MAOB MAOA HTR2A
34 major depressive disorder 29.4 SLC6A4 SLC6A3 PRL MAOB MAOA HTR2A
35 oppositional defiant disorder 29.4 WASF2 WASF1 SLC6A4 SLC6A3 RTN4 MAOA
36 panic disorder 29.3 SLC6A4 SLC6A3 PRL MAOA HTR2A HTR1B
37 tic disorder 29.3 SLC6A4 SLC6A3 RTN4 MAOA HTR2A DRD2
38 mood disorder 29.3 SLC6A4 SLC6A3 MAOB MAOA HTR2A HTR1B
39 anxiety 29.2 SLC6A4 SLC6A3 PRL MAOB MAOA HTR2A
40 autism spectrum disorder 29.1 SNAP25 SLC6A4 SLC6A3 MAOB MAOA HTR2A
41 psychotic disorder 29.0 SLC6A4 SLC6A3 RTN4 PRL MAOB MAOA
42 disease of mental health 28.7 WASF2 WASF1 SLC6A4 SLC6A3 RTN4 MAOA
43 mental depression 28.7 WASF2 WASF1 SLC6A4 SLC6A3 RTN4 MAOA
44 pathological gambling 28.6 WASF1 SLC6A4 SLC6A3 RTN4 MAOB MAOA
45 attention deficit-hyperactivity disorder 28.6 TTF2 SNAP25 SLC6A4 SLC6A3 PRL MAOB
46 substance abuse 28.6 WASF2 WASF1 SLC6A4 SLC6A3 RTN4 PRL
47 bipolar disorder 28.5 SNAP25 SLC6A4 SLC6A3 RTN4 PRL MAOA
48 alcohol use disorder 28.2 WASF2 WASF1 SLC6A4 SLC6A3 RTN4 HTR2A
49 substance dependence 28.2 WASF2 WASF1 SLC6A4 SLC6A3 RTN4 MAOA
50 alzheimer disease 28.1 SNAP25 SLC6A4 SLC6A3 RTN4 MAOB MAOA

Comorbidity relations with Antisocial Personality Disorder via Phenotypic Disease Network (PDN):


Schizophreniform Disorder

Graphical network of the top 20 diseases related to Antisocial Personality Disorder:



Diseases related to Antisocial Personality Disorder

Symptoms & Phenotypes for Antisocial Personality Disorder

MGI Mouse Phenotypes related to Antisocial Personality Disorder:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 ALDH2 COL25A1 COMT DRD2 GABRA2 HTR1B
2 endocrine/exocrine gland MP:0005379 9.81 ALDH2 COMT DRD2 HTR1B HTR2A PRL
3 muscle MP:0005369 9.65 ALDH2 COL25A1 DRD2 HTR1B HTR2A SLC6A3
4 nervous system MP:0003631 9.47 ALDH2 COL25A1 COMT DRD2 GABRA2 MAOA

Drugs & Therapeutics for Antisocial Personality Disorder

Drugs for Antisocial Personality Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
3
Naratriptan Approved, Investigational Phase 4 143388-64-1, 121679-13-8 4440
4 Dopamine Uptake Inhibitors Phase 4
5 Central Nervous System Stimulants Phase 4
6 Dopamine Agents Phase 4
7 Neurotransmitter Agents Phase 4
8 Vasoconstrictor Agents Phase 4
9 Serotonin 5-HT1 Receptor Agonists Phase 4
10 Serotonin Agents Phase 4
11 Serotonin Receptor Agonists Phase 4
12
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
13
Leuprolide Approved, Investigational Phase 2, Phase 3 53714-56-0 3911 657181
14
Pomegranate Experimental, Investigational Phase 2, Phase 3
15 Fertility Agents Phase 2, Phase 3
16 Antineoplastic Agents, Hormonal Phase 2, Phase 3
17 Omega 3 Fatty Acid Phase 2, Phase 3
18 Antioxidants Phase 2, Phase 3
19 Hemostatics Phase 1
20 Natriuretic Agents Phase 1
21 Coagulants Phase 1
22 Vasopressins Phase 1
23 Arginine Vasopressin Phase 1
24
Arginine Investigational, Nutraceutical Phase 1 74-79-3 6322
25
Cocaine Approved, Illicit 50-36-2 5760 446220
26
Nicotinamide Approved, Investigational 98-92-0 936
27
Ethanol Approved 64-17-5 702
28
Morphine Approved, Investigational 57-27-2 5288826
29
Niacin Approved, Investigational, Nutraceutical 59-67-6 938
30 Antiviral Agents
31 Anti-Infective Agents
32 Lisdexamfetamine Dimesylate
33 Anesthetics, Local
34 Anesthetics
35 Central Nervous System Depressants
36 Vitamin B3
37 Nicotinic Acids
38 Immunosuppressive Agents
39 Complement System Proteins
40 Complement Inactivating Agents
41 Immunologic Factors
42 Complement Factor H

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 Multimodal Treatment Study of Children With ADHD Completed NCT00000388 Phase 4 Anti-ADHD medication
2 Effects of Expectation, Medication and Placebo on Objective and Self-rated Performance During the Quantified Behavior Test in Patients With Untreated ADHD Completed NCT02473185 Phase 4 Methylphenidate
3 Effects of Expectation, Medication and Placebo on Objective and Self-rated Performance During the Quantified Behavior Test in Patients With Untreated ADHD and Substance Use Disorder Recruiting NCT02477280 Phase 4 Methylphenidate;Placebo
4 Efficacy of a Triptan in the Treatment of Hostility and Aggression Among Convicts With a Psychiatric Treatment Order Terminated NCT00282165 Phase 4 naratriptan;placebo
5 Leuprolide Acetate Suppresses Pedophilic Urges and Arousability Unknown status NCT00220350 Phase 2, Phase 3 leuprolide acetate
6 Omega-3 Supplements to Reduce Antisocial Behaviour in Young Offenders: A Randomized Controlled Trial Completed NCT03627312 Phase 2, Phase 3
7 Omega-3 Supplementation and Behavior Problems in Children and Adolescents Completed NCT02334098 Phase 2, Phase 3
8 Computerized Working Memory Training in Adults With Substance Abuse and Executive Function Deficits: A Randomised Controlled Trial. Unknown status NCT02068261 Phase 2
9 The Impact of Psychopathic Traits on the Efficacy of a Brief Intervention for Substance Use Completed NCT01532934 Phase 2
10 Phase 2 Study of Vasopressin Effects on Human Social Communication Completed NCT01327027 Phase 1 Vasopressin, Arginine, ADH;Placebo; Sterile Saline
11 Psychosocial Risk- and Protective Factors of Secondary School Dropout in Luxembourg: an Exploratory Case-control Study Unknown status NCT01354236
12 Intergenerational Transmission of Antisocial Behavior Unknown status NCT00060788
13 An Investigation of Cognitive Functioning and Brain Metabolites in Patients With Non-Cirrhotic Hepatitis-C Both Pre- and Post-Treatment With Antiviral Medication Unknown status NCT00188201
14 Passage à l'Acte en Maison d'arrêt : Recherche d'éléments Contextuels récurrents Prospectifs et rétrospectifs Completed NCT02493088
15 Early Exposure to Lead and Adult Antisocial Outcomes Completed NCT00285610
16 The Effect of Transcranial Direct Current Stimulation of the Prefrontal Cortex on Antisocial and Aggressive Behavior Completed NCT02427672
17 Investigation of Psychophysiological Response to Aversive Stimuli Over Time With Omega-3 Completed NCT03749824
18 Matching Cognitive Remediation to Cognitive Deficits in Substance-Abusing Inmates Completed NCT01428349
19 To Evaluate the Safety and Metabolic Profile of Vyvanse for the Treatment of ADHD in Euthymic Adults With Bipolar I/II Disorder Completed NCT01263548 lisdexamfetamine dimesylate
20 Impaired Decision-making in Adolescents: A Vulnerability Factor for the Development of Substance Use and Abuse. Completed NCT01253993
21 Developing Computer Based Treatments for Addiction Completed NCT00586534
22 Pregnancy Denial and Attachment Completed NCT02867579
23 A Follow-up, Family Study on Attention-deficit Hyperactivity Disorder Completed NCT00417781
24 Molecular Genetic Study of Schizophrenia: Parent-Offspring Trios Completed NCT00155506
25 Testing a Shortened Version of the AlAn's Game, Which Can be Delivered Through REDCap, in a Sample of Emerging Adults Recruiting NCT03834467
26 Effectiveness Trial of Treatment to Reduce Serious Antisocial Behavior in Emerging Adults With Mental Illness Recruiting NCT02922335
27 An 18-Month Psychotherapy of Borderline Personality Disorder Recruiting NCT03329677
28 Treatment of Justice-Involved Emerging Adults With Substance Use Disorders Recruiting NCT03035877
29 The Efficacy of a Compassion Focused Therapy-based Intervention in Detained Youth: A Clinical Trial Active, not recruiting NCT03971682
30 The Effect of Repeated Transcranial Direct Current Stimulation of the Prefrontal Cortex on Antisocial and Aggressive Behavior Active, not recruiting NCT02674516
31 Improving Treatment Engagement and Outcomes Among Justice-involved Veterans Active, not recruiting NCT02524171
32 Mentalization Based Treatment - Introductory Group for Male Prisoners With Borderline and/or Antisocial Personality Disorder in Her Majesty's Prison Barlinnie Not yet recruiting NCT04033835
33 Role of Oxytocin in Telling and Detecting Lies Withdrawn NCT02361177 Early Phase 1 Oxytocin

Search NIH Clinical Center for Antisocial Personality Disorder

Cochrane evidence based reviews: antisocial personality disorder

Genetic Tests for Antisocial Personality Disorder

Anatomical Context for Antisocial Personality Disorder

MalaCards organs/tissues related to Antisocial Personality Disorder:

40
Brain, Testes, Cortex, Prefrontal Cortex, Pituitary, Eye, Amygdala

Publications for Antisocial Personality Disorder

Articles related to Antisocial Personality Disorder:

(show top 50) (show all 1844)
# Title Authors PMID Year
1
Incremental effect for antisocial personality disorder genetic risk combining 5-HTTLPR and 5-HTTVNTR polymorphisms. 54 61
20363030 2010
2
Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder. 54 61
20175604 2010
3
The relationship between serotonin receptor 1B polymorphisms A-161T and alcohol dependence. 54 61
19519719 2009
4
MAOA-uVNTR polymorphism may modify the protective effect of ALDH2 gene against alcohol dependence in antisocial personality disorder. 54 61
19302089 2009
5
Monoamine oxidase A and childhood adversity as risk factors for conduct disorder in females. 54 61
18752729 2009
6
Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women. 54 61
17592478 2008
7
Possible interaction between MAOA and DRD2 genes associated with antisocial alcoholism among Han Chinese men in Taiwan. 54 61
17007976 2007
8
Relationship between dopaminergic neurotransmission, alcoholism, and Reward Deficiency syndrome. 54 61
15457501 2005
9
Analysis of monoamine oxidase A (MAO-A) promoter polymorphism in male heroin-dependent subjects: behavioural and personality correlates. 54 61
15088154 2004
10
The utility of the non-human primate; model for studying gene by environment interactions in behavioral research. 54 61
14653305 2003
11
The A1 allele of the DRD2 gene (TaqI A polymorphisms) is associated with antisocial personality in a sample of alcohol-dependent patients. 54 61
14643564 2003
12
Neither antisocial personality disorder nor antisocial alcoholism is associated with the MAO-A gene in Han Chinese males. 54 61
12824808 2003
13
Impulsive traits and 5-HT2A receptor promoter polymorphism in alcohol dependents: possible association but no influence of personality disorders. 54 61
11287798 2001
14
Dopamine transporter and D2-receptor density in late-onset alcoholism. 54 61
10639691 1999
15
Association of a regulatory polymorphism in the promoter region of the monoamine oxidase A gene with antisocial alcoholism. 54 61
10359483 1999
16
Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations. 54 61
9819067 1998
17
Gender differences in the relationship of antisocial personality disorder criteria to Psychopathy Checklist-Revised scores. 54 61
9573521 1998
18
Cannabis use, problem-gambling severity, and psychiatric disorders: Data from the National Epidemiological Survey on Alcohol and Related Conditions. 61
31246071 2020
19
Practical considerations for the evaluation and management of Attention Deficit Hyperactivity Disorder (ADHD) in adults. 61
31610922 2020
20
Characteristics Associated with a History of Physical and Sexual Abuse in a Community Corrections Sample. 61
31724472 2020
21
Associations between Parental Psychopathology and Sexual Behavior in an Outpatient Psychiatric Sample. 61
30376641 2020
22
A Psychometric Evaluation of the DSM-IV Criteria for Antisocial Personality Disorder: Dimensionality, Local Reliability, and Differential Item Functioning Across Gender. 61
29284276 2020
23
Homicidal Ideation and Forensic Psychopathology: Evidence From the 2016 Nationwide Emergency Department Sample (NEDS). 61
31404481 2020
24
22q11.2 duplication: a review of neuropsychiatric correlates and a newly observed case of prototypic sociopathy. 61
31836587 2019
25
Conduct Disorder: Biology and Developmental Trajectories. 61
31768912 2019
26
Crack users and violence. What is the relationship between trauma, antisocial personality disorder and posttraumatic stress disorder? 61
31233950 2019
27
Psychopathic Disorder Subtypes Based on Temperament and Character Differences. 61
31783703 2019
28
Improving characterization of psychopathy within the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), alternative model for personality disorders: Creation and validation of Personality Inventory for DSM-5 Triarchic scales. 61
31259604 2019
29
Increased prevalence of psychopathy and childhood trauma in homicide offenders with schizophrenia compared to nonviolent individuals with schizophrenia. 61
31443617 2019
30
Facets of externalizing psychopathology in relation to inhibitory control and error processing. 61
31634490 2019
31
Validation of the Recent Life Changes Questionnaire (RLCQ) for stress measurement among adults residing in urban communities in Pakistan. 61
31639054 2019
32
Persistence and Subtype Stability of ADHD Among Substance Use Disorder Treatment Seekers. 61
26922805 2019
33
Associations between the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, alternative model of antisocial personality disorder, psychopathic specifier, and psychopathy-related facets with aggression in a sample of incarcerated males. 61
31621362 2019
34
Prevalence and correlates of suicide attempt among Chinese individuals receiving methadone maintenance treatment for heroin dependence. 61
31666637 2019
35
Sensorimotor Gating in Cocaine-Related Disorder with Comorbid Schizophrenia or Antisocial Personality Disorder. 61
31287382 2019
36
Behavioral and electrophysiological responses to fairness norm violations in antisocial offenders. 61
29397410 2019
37
Implications for the Measurement of Psychopathy in the DSM-5 Using the Computerized Adaptive Test of Personality Disorder. 61
29873521 2019
38
Concepts of mental disorders in the United Kingdom: Similarities and differences between the lay public and psychiatrists. 61
31311429 2019
39
CR-19-0950: Event-related responses to alcohol-related stimuli in Mexican-American young adults: Relation to age, gender, comorbidity and "dark side" symptoms. 61
31323376 2019
40
Childhood sexual abuse is significantly associated with subsequent sexual offending: New evidence among federal correctional clients. 61
31252352 2019
41
Evaluating dysfunction in cognition and reward among offenders with antisocial personality disorder. 61
30816777 2019
42
Antisocial Traits, Negative Emotionality, and Trajectories of Relationship Quality in Mexican-Origin Couples. 61
31403390 2019
43
Executive function, attention, and memory deficits in antisocial personality disorder and psychopathy. 61
31200194 2019
44
Effects of Childhood and Adult Persistent Attention-Deficit/Hyperactivity Disorder on Risk of Motor Vehicle Crashes: Results From the Multimodal Treatment Study of ADHD. 61
31445873 2019
45
The association between SYT1-rs2251214 and cocaine use disorder further supports its role in psychiatry. 61
31059723 2019
46
Temperament and character in homicidal patients with schizophrenia. 61
31215824 2019
47
The association between personality disorders/traits and violent eye trauma. 61
30858566 2019
48
Rare copy number variation in extremely impulsively violent males. 61
30411505 2019
49
Comorbidity Patterns Among Patients With Opioid Use Disorder and Problem Gambling: ADHD Status Predicts Class Membership. 61
30999811 2019
50
The etiology of antisocial personality disorder: The differential roles of adverse childhood experiences and childhood psychopathology. 61
31079021 2019

Variations for Antisocial Personality Disorder

Expression for Antisocial Personality Disorder

Search GEO for disease gene expression data for Antisocial Personality Disorder.

Pathways for Antisocial Personality Disorder

Pathways related to Antisocial Personality Disorder according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.85 SNAP25 SLC6A4 SLC6A3 MAOA GABRA2 COMT
2
Show member pathways
12.63 SLC6A3 MAOB MAOA DRD2 COMT
3 12.03 SNAP25 SLC6A4 MAOA HTR2A
4
Show member pathways
11.85 SLC6A3 MAOB MAOA DRD2
5 11.83 SLC6A4 MAOB MAOA HTR2A HTR1B
6
Show member pathways
11.81 HTR2A HTR1B DRD2
7
Show member pathways
11.72 MAOB MAOA ALDH2
8
Show member pathways
11.68 MAOB MAOA ALDH2
9
Show member pathways
11.62 MAOB MAOA COMT
10
Show member pathways
11.47 MAOB MAOA ALDH2
11
Show member pathways
11.32 SLC6A4 SLC6A3 MAOA
12
Show member pathways
11.2 MAOB MAOA ALDH2
13 11.07 SLC6A4 MAOA HTR2A HTR1B
14 10.86 SNAP25 PRL DRD2 ANKK1
15
Show member pathways
10.77 SLC6A4 SLC6A3 MAOA COMT ALDH2
16 10.76 MAOB MAOA COMT
17
Show member pathways
10.69 MAOB MAOA ALDH2
18
Show member pathways
10.63 MAOB MAOA COMT ALDH2
19
Show member pathways
10.53 SLC6A4 SLC6A3 MAOB MAOA HTR1B DRD2
20 10.5 MAOA ALDH2

GO Terms for Antisocial Personality Disorder

Cellular components related to Antisocial Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.98 SLC6A4 SLC6A3 HTR2A HTR1B GABRA2 DRD2
2 dendrite GO:0030425 9.77 HTR2A HTR1B GABRA2 DRD2 COMT
3 axon GO:0030424 9.63 SNAP25 SLC6A3 HTR2A GABRA2 DRD2 COMT
4 dopaminergic synapse GO:0098691 9.4 SLC6A3 DRD2
5 SCAR complex GO:0031209 9.32 WASF2 WASF1
6 serotonergic synapse GO:0099154 9.26 SLC6A4 HTR1B
7 integral component of postsynaptic membrane GO:0099055 9.26 SLC6A4 SLC6A3 HTR2A DRD2
8 integral component of presynaptic membrane GO:0099056 9.02 SLC6A4 SLC6A3 HTR2A HTR1B DRD2

Biological processes related to Antisocial Personality Disorder according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.86 SNAP25 HTR2A HTR1B GABRA2
2 response to toxic substance GO:0009636 9.77 SLC6A4 MAOB DRD2
3 locomotory behavior GO:0007626 9.74 SNAP25 SLC6A3 DRD2
4 regulation of synaptic vesicle exocytosis GO:2000300 9.65 HTR2A HTR1B DRD2
5 neurotransmitter transport GO:0006836 9.63 SLC6A4 SLC6A3 GABRA2
6 behavioral response to cocaine GO:0048148 9.62 HTR2A DRD2
7 response to iron ion GO:0010039 9.62 SLC6A3 DRD2
8 response to ethanol GO:0045471 9.62 SLC6A3 MAOB HTR1B DRD2
9 vasoconstriction GO:0042310 9.61 SLC6A4 HTR1B
10 prepulse inhibition GO:0060134 9.61 SLC6A3 DRD2
11 dopamine metabolic process GO:0042417 9.6 DRD2 COMT
12 neurotransmitter biosynthetic process GO:0042136 9.58 SLC6A4 SLC6A3
13 G protein-coupled receptor internalization GO:0002031 9.58 HTR1B DRD2
14 response to cocaine GO:0042220 9.58 SLC6A3 HTR1B DRD2
15 behavior GO:0007610 9.55 HTR2A HTR1B
16 catecholamine metabolic process GO:0006584 9.54 MAOA COMT
17 regulation of dopamine secretion GO:0014059 9.54 HTR2A HTR1B DRD2
18 adenohypophysis development GO:0021984 9.52 SLC6A3 DRD2
19 monoamine transport GO:0015844 9.51 SLC6A4 SLC6A3
20 response to drug GO:0042493 9.5 SLC6A4 SLC6A3 MAOB HTR2A HTR1B DRD2
21 drinking behavior GO:0042756 9.49 HTR1B DRD2
22 negative regulation of serotonin secretion GO:0014063 9.43 MAOB HTR1B
23 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.43 HTR2A HTR1B DRD2
24 neurotransmitter catabolic process GO:0042135 9.33 MAOB MAOA COMT
25 dopamine catabolic process GO:0042420 8.92 SLC6A3 MAOB MAOA COMT

Molecular functions related to Antisocial Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotransmitter:sodium symporter activity GO:0005328 9.37 SLC6A4 SLC6A3
2 dopamine binding GO:0035240 9.32 SLC6A3 DRD2
3 monoamine transmembrane transporter activity GO:0008504 9.26 SLC6A4 SLC6A3
4 drug binding GO:0008144 9.26 SLC6A3 HTR2A HTR1B DRD2
5 primary amine oxidase activity GO:0008131 9.16 MAOB MAOA
6 serotonin binding GO:0051378 8.8 SLC6A4 HTR2A HTR1B

Sources for Antisocial Personality Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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