MCID: ANT011
MIFTS: 50

Antisocial Personality Disorder

Categories: Mental diseases

Aliases & Classifications for Antisocial Personality Disorder

MalaCards integrated aliases for Antisocial Personality Disorder:

Name: Antisocial Personality Disorder 12 77 56 45 15 74
Psychopathic Personality Disorder 12
Dissocial Personality Disorder 12
Psychopathic Personality 12
Sociopathic Personality 12
Psychopath.personality 12
Asocial Personality 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10939
ICD9CM 36 301.7
MeSH 45 D000987
NCIt 51 C88413
SNOMED-CT 69 26665006
ICD10 34 F60.2
UMLS 74 C0003431

Summaries for Antisocial Personality Disorder

Disease Ontology : 12 A personality disorder that involves a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood.

MalaCards based summary : Antisocial Personality Disorder, also known as psychopathic personality disorder, is related to impulse control disorder and conduct disorder. An important gene associated with Antisocial Personality Disorder is MAOA (Monoamine Oxidase A), and among its related pathways/superpathways are Circadian entrainment and Transmission across Chemical Synapses. The drugs Naratriptan and Vasoconstrictor Agents have been mentioned in the context of this disorder. Affiliated tissues include cortex, prefrontal cortex and testes, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 77 Antisocial personality disorder (ASPD or APD) is a personality disorder characterized by a long term... more...

Related Diseases for Antisocial Personality Disorder

Diseases related to Antisocial Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 impulse control disorder 32.0 ANKK1 DRD2
2 conduct disorder 31.3 ALDH2 COMT DRD2 MAOA SLC6A3 SLC6A4
3 anxiety 30.6 COMT MAOA SLC6A4
4 cocaine dependence 30.5 DRD2 SLC6A3 SLC6A4
5 heroin dependence 30.3 ANKK1 DRD2
6 personality disorder 30.1 ALDH2 ANKK1 COMT DRD2 HTR1B MAOA
7 drug dependence 30.1 ANKK1 DRD2 SLC6A4
8 borderline personality disorder 30.1 COMT HTR1B MAOA SLC6A4
9 substance dependence 29.9 DRD2 HTR1B MAOA SLC6A3 SLC6A4
10 bipolar disorder 29.8 COMT DRD2 SLC6A3 SLC6A4
11 generalized anxiety disorder 29.8 COMT DRD2 MAOA SLC6A4
12 pathological gambling 29.7 DRD2 MAOA MAOB SLC6A3 SLC6A4
13 disease of mental health 29.6 COMT DRD2 MAOA SLC6A3 SLC6A4
14 bulimia nervosa 29.6 COMT HTR1B SLC6A4
15 substance abuse 29.6 COMT DRD2 HTR1B MAOA SLC6A3 SLC6A4
16 alexithymia 29.4 ANKK1 COMT DRD2 SLC6A4
17 post-traumatic stress disorder 29.0 COMT DRD2 MAOA MAOB SLC6A4
18 schizophrenia 28.7 COMT DRD2 HTR1B MAOA MAOB SLC6A3
19 alcohol dependence 28.1 ALDH2 ANKK1 COMT DRD2 HTR1B MAOA
20 attention deficit-hyperactivity disorder 27.8 ANKK1 COMT DRD2 HTR1B MAOA MAOB
21 depression 10.4
22 avoidant personality disorder 10.3 MAOA SLC6A4
23 tic disorder 10.3 DRD2 SLC6A3
24 dysthymic disorder 10.3 MAOA SLC6A4
25 kleptomania 10.3 MAOA SLC6A4
26 agoraphobia 10.3 MAOA SLC6A4
27 periodic limb movement disorder 10.3 DRD2 SLC6A4
28 striatonigral degeneration 10.2 DRD2 SLC6A3
29 pol iii-related leukodystrophies 10.2
30 neurotic disorder 10.2
31 taqi polymorphism 10.2 ANKK1 DRD2
32 social phobia 10.2 DRD2 MAOA SLC6A4
33 stuttering 10.1 DRD2 SLC6A3
34 sexual sadism 10.1
35 somatization disorder 10.1
36 exhibitionism 10.1 MAOA MAOB
37 alcohol-induced mental disorder 10.1 DRD2 SLC6A3 SLC6A4
38 alcoholic psychosis 10.1 DRD2 SLC6A3 SLC6A4
39 dependent personality disorder 10.1 MAOA MAOB
40 cocaine abuse 10.1 DRD2 SLC6A3 SLC6A4
41 migraine without aura 10.1 DRD2 SLC6A4
42 opiate dependence 10.1 DRD2 SLC6A4
43 paraphilia disorder 10.1 MAOA MAOB
44 migraine with aura 10.1 DRD2 SLC6A4
45 pure autonomic failure 10.1 MAOA MAOB
46 premature ejaculation 10.0 HTR1B SLC6A3 SLC6A4
47 phobia, specific 10.0 COMT MAOA
48 atypical depressive disorder 10.0 MAOA MAOB SLC6A4
49 serotonin syndrome 10.0 MAOA MAOB SLC6A4
50 dementia 10.0

Comorbidity relations with Antisocial Personality Disorder via Phenotypic Disease Network (PDN):


Schizophreniform Disorder

Graphical network of the top 20 diseases related to Antisocial Personality Disorder:



Diseases related to Antisocial Personality Disorder

Symptoms & Phenotypes for Antisocial Personality Disorder

MGI Mouse Phenotypes related to Antisocial Personality Disorder:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.13 ALDH2 COL25A1 COMT DRD2 HTR1B MAOA
2 homeostasis/metabolism MP:0005376 9.97 ALDH2 COL25A1 COMT DRD2 MAOA MAOB
3 cardiovascular system MP:0005385 9.95 ALDH2 COMT DRD2 HTR1B MAOA SLC6A4
4 endocrine/exocrine gland MP:0005379 9.91 ALDH2 COMT DRD2 HTR1B SLC6A3 SLC6A4
5 nervous system MP:0003631 9.81 ALDH2 COL25A1 COMT DRD2 MAOA MAOB
6 muscle MP:0005369 9.8 ALDH2 COL25A1 DRD2 HTR1B SLC6A3 SLC6A4
7 reproductive system MP:0005389 9.43 ALDH2 COMT DRD2 HTR1B SLC6A3 SNAP25
8 taste/olfaction MP:0005394 8.8 DRD2 SLC6A3 SNAP25

Drugs & Therapeutics for Antisocial Personality Disorder

Drugs for Antisocial Personality Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Naratriptan Approved, Investigational Phase 4 121679-13-8, 143388-64-1 4440
2 Vasoconstrictor Agents Phase 4,Phase 1
3 Neurotransmitter Agents Phase 4
4 Serotonin 5-HT1 Receptor Agonists Phase 4
5 Serotonin Receptor Agonists Phase 4
6 Serotonin Agents Phase 4
7
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
8
Pomegranate Experimental, Investigational Phase 2, Phase 3
9 Omega 3 Fatty Acid Phase 2, Phase 3,Phase 3,Not Applicable
10 Antioxidants Phase 2, Phase 3
11 Hemostatics Phase 1
12 Coagulants Phase 1
13 Natriuretic Agents Phase 1
14 Vasopressins Phase 1
15 arginine Phase 1
16 Arginine Vasopressin Phase 1
17
Yohimbine Approved, Investigational, Vet_approved 146-48-5 8969
18
Norepinephrine Approved 51-41-2 439260
19
Guanfacine Approved, Investigational 29110-47-2 3519
20
Dopamine Approved 62-31-7, 51-61-6 681
21
Morphine Approved, Investigational Not Applicable 57-27-2 5288826
22
Ethanol Approved Not Applicable 64-17-5 702
23
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
24
tannic acid Approved Not Applicable 1401-55-4
25 Autonomic Agents
26 Adrenergic Agonists
27 Sympathomimetics
28 Peripheral Nervous System Agents
29 Yohimbe
30 Adrenergic Agents
31 Adrenergic alpha-Agonists
32 Dopamine Uptake Inhibitors
33 Central Nervous System Stimulants
34 Dopamine Agents
35 Neurotransmitter Uptake Inhibitors
36 Lisdexamfetamine Dimesylate

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 Multimodal Treatment Study of Children With Attention Deficit and Hyperactivity Disorder (MTA) Completed NCT00000388 Phase 4 Anti-ADHD medication
2 Efficacy of a Triptan in the Treatment of Hostility and Aggression Among Convicts With a Psychiatric Treatment Order Terminated NCT00282165 Phase 4 naratriptan;placebo
3 Omega-3 Supplementation and Behavior Problems Completed NCT02334098 Phase 2, Phase 3
4 Effect of Omega-3 Supplementation on Child Behavior Problems Completed NCT02016079 Phase 2, Phase 3
5 Omega-3 Supplements to Reduce Antisocial Behaviour in Young Offenders Completed NCT03627312 Phase 2, Phase 3
6 Working Memory Training in Adults With Substance Abuse and Executive Function Deficits. Unknown status NCT02068261 Phase 2
7 The Impact of Psychopathic Traits on the Efficacy of a Substance Use Intervention Completed NCT01532934 Phase 2
8 Neurological Influences on Drug Prevention Intervention Completed NCT00198939 Phase 1, Phase 2
9 Youth Drug Abuse Family and Cognitive-Behavioral Therapy Completed NCT00198874 Phase 2
10 Vasopressin Effects on Human Social Communication Completed NCT01327027 Phase 1 Vasopressin, Arginine, ADH;Placebo; Sterile Saline
11 Antisocial Behavior: Passing From Parent to Child to Grandchild Unknown status NCT00060788
12 Psychobiological Effects of Meditation on Offenders With Psychopathy Unknown status NCT02894203 Not Applicable
13 Mental Health Related to School Dropout in Luxembourg Unknown status NCT01354236
14 Conduct Disorder in Prison: Search for Prospective and Retrospective Recurring and Contextual Elements Completed NCT02493088
15 Matching Cognitive Remediation to Cognitive Deficits in Substance-Abusing Inmates Completed NCT01428349 Not Applicable
16 Impaired Decision-making in Adolescents Completed NCT01253993
17 The Role of Norepinephrine in Emotional Processing Completed NCT00109642
18 Psychological Mechanisms of Behavioral Dysregulation Completed NCT00352456
19 Early Exposure to Lead and Adult Antisocial Outcomes Completed NCT00285610
20 To Evaluate the Safety and Metabolic Profile of Vyvanse for the Treatment of ADHD in Euthymic Adults With Bipolar I/II Disorder Completed NCT01263548 lisdexamfetamine dimesylate
21 Effectiveness of a Cognitive-behavioral Program of Coping With Psychological Stress in People With Retinitis Pigmentosa Completed NCT03368027 Not Applicable
22 Investigation of Psychophysiological Response to Aversive Stimuli Over Time With Omega-3 Completed NCT03749824 Not Applicable
23 European Comparative Effectiveness Research on Internet-based Depression Treatment Completed NCT02542891 Not Applicable
24 Emotion Recognition Training in Antisocial Violent Offenders With Psychopathic Traits Recruiting NCT03382808 Not Applicable
25 An 18-Month Psychotherapy of Borderline Personality Disorder Recruiting NCT03329677 Not Applicable
26 Multisystemic Therapy-Emerging Adults (MST-EA) for Substance Abuse Recruiting NCT03035877 Not Applicable
27 Multisystemic Therapy-Emerging Adults Trial Recruiting NCT02922335 Not Applicable
28 FCT Study: Reducing the Need for Out-of-Home Placements Recruiting NCT03641664 Not Applicable
29 Dissemination and Implementation Field Trial of Dialectical Behavior Therapy for Adolescents With Bipolar Disorder Recruiting NCT03661333 Not Applicable
30 Treating Co-Occurring Substance Use and Mental Disorders Among Jail Inmates Recruiting NCT02214667 Not Applicable
31 Youth to Text or Telehealth for Engagement in HIV Care Recruiting NCT03681145 Not Applicable
32 Improving Emotion Regulation Skills Among Adolescents Attempting to Lose Weight Recruiting NCT03393221 Not Applicable
33 Mentalization-based Training for Adolescents With Conduct Disorder (MBT-CD) Recruiting NCT02988453 Not Applicable
34 Justice-Involved Veterans and Moral Reconation Therapy Active, not recruiting NCT02524171 Not Applicable
35 The Effect of Repeated Prefrontal Cortex Stimulation on Antisocial and Aggressive Behavior Active, not recruiting NCT02674516 Not Applicable
36 The Effect of Prefrontal Cortex Stimulation on Antisocial and Aggressive Behavior Active, not recruiting NCT02427672 Not Applicable
37 Multisite Prevention of Conduct Problems (Fast Track) Active, not recruiting NCT01653535 Not Applicable
38 Testing a Shortened Version of the AlAn's Game Not yet recruiting NCT03834467 Not Applicable
39 Role of Oxytocin in Telling and Detecting Lies Withdrawn NCT02361177 Early Phase 1 Oxytocin

Search NIH Clinical Center for Antisocial Personality Disorder

Cochrane evidence based reviews: antisocial personality disorder

Genetic Tests for Antisocial Personality Disorder

Anatomical Context for Antisocial Personality Disorder

MalaCards organs/tissues related to Antisocial Personality Disorder:

42
Cortex, Prefrontal Cortex, Testes, Brain, Eye, Thyroid, Amygdala

Publications for Antisocial Personality Disorder

Articles related to Antisocial Personality Disorder:

(show top 50) (show all 403)
# Title Authors Year
1
Should childhood conduct disorder be necessary to diagnose antisocial personality disorder in adults? ( 30699216 )
2019
2
Evaluating dysfunction in cognition and reward among offenders with antisocial personality disorder. ( 30816777 )
2019
3
Post-traumatic stress disorder and having antisocial peers in adolescence are risk factors for the development of antisocial personality disorder. ( 30822743 )
2019
4
Single-Photon Emission Computed Tomography and Positron Emission Tomography Studies of Antisocial Personality Disorder and Aggression: a Targeted Review. ( 30852703 )
2019
5
Episodic memory and consciousness in antisocial personality disorder and conduct disorder. ( 29353574 )
2018
6
The Endocannabinoid System, Aggression, and the Violence of Synthetic Cannabinoid Use, Borderline Personality Disorder, Antisocial Personality Disorder, and Other Psychiatric Disorders. ( 29636670 )
2018
7
Movies in Mind: 'We need to talk about Kevin'-Is an antisocial personality disorder 'born' or 'made'? ( 29676160 )
2018
8
The effects of working memory load and attention refocusing on delay discounting rates in alcohol use disorder with comorbid antisocial personality disorder. ( 29277285 )
2018
9
Corticostriatal Connectivity in Antisocial Personality Disorder by MAO-A Genotype and Its Relationship to Aggressive Behavior. ( 29746646 )
2018
10
Changes in Resting EEG in Colombian Ex-combatants ith Antisocial Personality Disorder. ( 29754711 )
2018
11
Treatment of antisocial personality disorder: Development of a practice focused framework. ( 29853015 )
2018
12
Early adolescent aggression predicts antisocial personality disorder in young adults: a population-based study. ( 30019148 )
2018
13
Genetic and environmental relations of executive functions to antisocial personality disorder symptoms and psychopathy. ( 30576766 )
2018
14
Reduced White Matter Integrity in Antisocial Personality Disorder: A Diffusion Tensor Imaging Study. ( 28223713 )
2017
15
Association of monoamine oxidase-A genetic variants and amygdala morphology in violent offenders with antisocial personality disorder and high psychopathic traits. ( 28851912 )
2017
16
Orbito-frontal cortex volumes in patients with antisocial personality disorder. ( 28784365 )
2017
17
A prospective, longitudinal, study of men with borderline personality disorder with and without comorbid antisocial personality disorder. ( 29225887 )
2017
18
A Psychometric Evaluation of the DSM-IV Criteria for Antisocial Personality Disorder: Dimensionality, Local Reliability, and Differential Item Functioning Across Gender. ( 29284276 )
2017
19
Oxytocin improves facial emotion recognition in young adults with antisocial personality disorder. ( 28865940 )
2017
20
More inflammation but less brain-derived neurotrophic factor in antisocial personality disorder. ( 28810156 )
2017
21
Neuropsychology and emotion processing in violent individuals with antisocial personality disorder or schizophrenia: The same or different? A systematic review and meta-analysis. ( 28992741 )
2017
22
Neural Mechanisms Underlying Affective Theory of Mind in Violent Antisocial Personality Disorder and/or Schizophrenia. ( 28199713 )
2017
23
Did you get any help? A post-hoc secondary analysis of a randomized controlled trial of psychoeducation for patients with antisocial personality disorder in outpatient substance abuse treatment programs. ( 28068951 )
2017
24
Neurocognitive dysfunction in problem gamblers with co-occurring antisocial personality disorder. ( 28528231 )
2017
25
Antisocial Personality Disorder in Older Adults: A Critical Review. ( 28954596 )
2017
26
Genetic and Environmental Structure of DSM-IV Criteria for Antisocial Personality Disorder: A Twin Study. ( 28108863 )
2017
27
Monoamine Oxidase A in Antisocial Personality Disorder and Borderline Personality Disorder. ( 29568721 )
2017
28
Offenders With Antisocial Personality Disorder Display More Impairments in Mentalizing. ( 27064853 )
2016
29
Evidence for an agitated-aggressive syndrome in early-onset psychosis correlated with antisocial personality disorder, forensic history, and substance use disorder. ( 27117676 )
2016
30
Experiential avoidance, empathy, and anger-related attitudesin antisocial personality disorder. ( 28081330 )
2016
31
Examining the DSM-5 Alternative Personality Disorder Model Operationalization of Antisocial Personality Disorder and Psychopathy in a Male Correctional Sample. ( 26914324 )
2016
32
Heightened early-attentional stimulus orienting and impulsive action in men with antisocial personality disorder. ( 27662886 )
2016
33
Clinical differences between cocaine-dependent patients with and without antisocial personality disorder. ( 27839828 )
2016
34
The Relationship between Aggression and Serum Thyroid Hormone Level in Individuals Diagnosed with Antisocial Personality Disorder. ( 28360783 )
2016
35
Individual and Network Correlates of Antisocial Personality Disorder Among Rural Nonmedical Prescription Opioid Users. ( 27171488 )
2016
36
Neurocognitive Deficits Associated with Antisocial Personality Disorder in Non-treatment-seeking Young Adults. ( 27236178 )
2016
37
Genome-wide association study of antisocial personality disorder. ( 27598967 )
2016
38
Disrupted functional connectome in antisocial personality disorder. ( 27541949 )
2016
39
A randomised controlled trial of mentalization-based treatment versus structured clinical management for patients with comorbid borderline personality disorder and antisocial personality disorder. ( 27577562 )
2016
40
Association of ventral striatum monoamine oxidase-A binding and functional connectivity in antisocial personality disorder with high impulsivity: A positron emission tomography and functional magnetic resonance imaging study. ( 26908392 )
2016
41
Comorbid trajectories of substance use as predictors of Antisocial Personality Disorder, Major Depressive Episode, and Generalized Anxiety Disorder. ( 27344118 )
2016
42
Reduced cortical thickness and increased surface area in antisocial personality disorder. ( 27600947 )
2016
43
Aberrant functional brain connectome in people with antisocial personality disorder. ( 27257047 )
2016
44
An Adverse Family Environment During Adolescence Predicts Marijuana Use and Antisocial Personality Disorder in Adulthood. ( 27034610 )
2016
45
Psychopathy, Antisocial Personality Disorder, and Reconviction in an Australian Sample of Forensic Patients. ( 27288398 )
2016
46
Facial emotion perception impairments in schizophrenia patients with comorbid antisocial personality disorder. ( 26778631 )
2016
47
Modulatory effects of psychopathy on Wisconsin Card Sorting Test performance in male offenders with Antisocial Personality Disorder. ( 26708441 )
2016
48
Impulsive lifestyle counseling to prevent dropout from treatment for substance use disorders in people with antisocial personality disorder: A randomized study. ( 26882500 )
2016
49
Neural Substrates of Antisocial Personality Disorder: Current State and Future Directions. ( 27776462 )
2016
50
The Natural History of Antisocial Personality Disorder. ( 26175389 )
2015

Variations for Antisocial Personality Disorder

Expression for Antisocial Personality Disorder

Search GEO for disease gene expression data for Antisocial Personality Disorder.

Pathways for Antisocial Personality Disorder

Pathways related to Antisocial Personality Disorder according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.79 COMT DRD2 MAOA MAOB SLC6A3
2
Show member pathways
12.74 ALDH2 COMT MAOA SLC6A3 SLC6A4 SNAP25
3 11.94 MAOA SLC6A4 SNAP25
4
Show member pathways
11.74 DRD2 MAOA MAOB SLC6A3
5 11.68 HTR1B MAOA MAOB SLC6A4
6
Show member pathways
11.66 ALDH2 MAOA MAOB
7
Show member pathways
11.57 COMT MAOA MAOB
8
Show member pathways
11.43 ALDH2 MAOA MAOB
9
Show member pathways
11.29 MAOA SLC6A3 SLC6A4
10
Show member pathways
11.16 ALDH2 MAOA MAOB
11 11.07 MAOB SLC6A3
12 11.06 HTR1B MAOA SLC6A4
13
Show member pathways
10.88 COMT MAOA
14 10.58 COMT MAOA MAOB
15
Show member pathways
10.45 ALDH2 MAOA MAOB
16
Show member pathways
10.44 ALDH2 COMT MAOA SLC6A3 SLC6A4
17
Show member pathways
10.43 ALDH2 COMT MAOA MAOB

GO Terms for Antisocial Personality Disorder

Cellular components related to Antisocial Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.77 COL25A1 DRD2 HTR1B SLC6A3 SLC6A4
2 axon GO:0030424 9.56 COMT DRD2 SLC6A3 SNAP25
3 integral component of postsynaptic membrane GO:0099055 9.33 DRD2 SLC6A3 SLC6A4
4 dopaminergic synapse GO:0098691 9.32 DRD2 SLC6A3
5 serotonergic synapse GO:0099154 8.96 HTR1B SLC6A4
6 integral component of presynaptic membrane GO:0099056 8.92 DRD2 HTR1B SLC6A3 SLC6A4

Biological processes related to Antisocial Personality Disorder according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 response to toxic substance GO:0009636 9.71 DRD2 MAOB SLC6A4
2 locomotory behavior GO:0007626 9.69 DRD2 SLC6A3 SNAP25
3 neurotransmitter transport GO:0006836 9.62 SLC6A3 SLC6A4
4 response to nicotine GO:0035094 9.62 DRD2 SLC6A3
5 positive regulation of multicellular organism growth GO:0040018 9.61 DRD2 SLC6A3
6 feeding behavior GO:0007631 9.61 DRD2 HTR1B
7 associative learning GO:0008306 9.6 DRD2 SNAP25
8 response to iron ion GO:0010039 9.59 DRD2 SLC6A3
9 vasoconstriction GO:0042310 9.58 HTR1B SLC6A4
10 dopamine metabolic process GO:0042417 9.58 COMT DRD2
11 prepulse inhibition GO:0060134 9.57 DRD2 SLC6A3
12 neurotransmitter biosynthetic process GO:0042136 9.56 SLC6A3 SLC6A4
13 response to ethanol GO:0045471 9.56 DRD2 HTR1B MAOB SLC6A3
14 G protein-coupled receptor internalization GO:0002031 9.55 DRD2 HTR1B
15 catecholamine metabolic process GO:0006584 9.52 COMT MAOA
16 response to cocaine GO:0042220 9.5 DRD2 HTR1B SLC6A3
17 adenohypophysis development GO:0021984 9.49 DRD2 SLC6A3
18 monoamine transport GO:0015844 9.48 SLC6A3 SLC6A4
19 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.46 DRD2 HTR1B
20 drinking behavior GO:0042756 9.43 DRD2 HTR1B
21 response to drug GO:0042493 9.43 COMT DRD2 HTR1B MAOB SLC6A3 SLC6A4
22 neurotransmitter uptake GO:0001504 9.4 SLC6A3 SNAP25
23 negative regulation of serotonin secretion GO:0014063 9.37 HTR1B MAOB
24 neurotransmitter catabolic process GO:0042135 9.33 COMT MAOA MAOB
25 dopamine catabolic process GO:0042420 8.92 COMT MAOA MAOB SLC6A3

Molecular functions related to Antisocial Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 syntaxin-1 binding GO:0017075 9.4 SLC6A4 SNAP25
2 neurotransmitter:sodium symporter activity GO:0005328 9.37 SLC6A3 SLC6A4
3 dopamine binding GO:0035240 9.32 DRD2 SLC6A3
4 serotonin binding GO:0051378 9.26 HTR1B SLC6A4
5 monoamine transmembrane transporter activity GO:0008504 9.16 SLC6A3 SLC6A4
6 drug binding GO:0008144 9.13 DRD2 HTR1B SLC6A3
7 primary amine oxidase activity GO:0008131 8.62 MAOA MAOB

Sources for Antisocial Personality Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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