MCID: ANS001
MIFTS: 23

Anus Basaloid Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Anus Basaloid Carcinoma

MalaCards integrated aliases for Anus Basaloid Carcinoma:

Name: Anus Basaloid Carcinoma 12 15
Basaloid Carcinoma of the Anus 12 74
Anal Basaloid Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7174
NCIt 51 C8256
UMLS 74 C0280470

Summaries for Anus Basaloid Carcinoma

MalaCards based summary : Anus Basaloid Carcinoma, also known as basaloid carcinoma of the anus, is related to basal cell carcinoma and basal cell carcinoma 1. An important gene associated with Anus Basaloid Carcinoma is CYLD (CYLD Lysine 63 Deubiquitinase). The drugs Fluorouracil and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include tonsil and thymus.

Related Diseases for Anus Basaloid Carcinoma

Graphical network of the top 20 diseases related to Anus Basaloid Carcinoma:



Diseases related to Anus Basaloid Carcinoma

Symptoms & Phenotypes for Anus Basaloid Carcinoma

Drugs & Therapeutics for Anus Basaloid Carcinoma

Drugs for Anus Basaloid Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 3,Phase 2 51-21-8 3385
2
Cisplatin Approved Phase 3,Phase 2 15663-27-1 2767 441203 84093
3 Antimetabolites, Antineoplastic Phase 3,Phase 2
4 Immunosuppressive Agents Phase 3,Phase 2
5 Immunologic Factors Phase 3,Phase 2
6 Antimetabolites Phase 3,Phase 2
7 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
8 Alkylating Agents Phase 3,Phase 2
9 Anti-Bacterial Agents Phase 3,Phase 2
10 Mitomycins Phase 3,Phase 2
11 Antibiotics, Antitubercular Phase 3,Phase 2
12
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
13
nivolumab Approved Phase 2 946414-94-4
14
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
15
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
16
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
17 Antineoplastic Agents, Immunological Phase 2
18 Albumin-Bound Paclitaxel Phase 2
19 Antineoplastic Agents, Phytogenic Phase 2
20 Antimitotic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Unknown status NCT00003652 Phase 3 cisplatin;fluorouracil
2 Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Completed NCT00003596 Phase 3 cisplatin;fluorouracil;mitomycin C
3 Radiation Therapy Plus Fluorouracil With or Without Additional Chemotherapy in Treating Patients With Primary Anal Cancer Completed NCT00025090 Phase 3 cisplatin;fluorouracil;mitomycin C
4 Intensity-Modulated Radiation Therapy, Fluorouracil, and Mitomycin C in Treating Patients With Invasive Anal Cancer Completed NCT00423293 Phase 2 fluorouracil;mitomycin C
5 Combined Modality Therapy for Patients With With HIV and Stage I, Stage II, or Stage III Anal Cancer Completed NCT00324415 Phase 2 cisplatin;fluorouracil
6 Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer Recruiting NCT03233711 Phase 2
7 Cisplatin and Fluorouracil Compared With Carboplatin and Paclitaxel in Treating Patients With Inoperable Locally Recurrent or Metastatic Anal Cancer Active, not recruiting NCT02560298 Phase 2 Capecitabine;Carboplatin;Cisplatin;Fluorouracil;Paclitaxel
8 Cetuximab, Cisplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Anal Cancer Active, not recruiting NCT00316888 Phase 2 cisplatin;fluorouracil

Search NIH Clinical Center for Anus Basaloid Carcinoma

Genetic Tests for Anus Basaloid Carcinoma

Anatomical Context for Anus Basaloid Carcinoma

MalaCards organs/tissues related to Anus Basaloid Carcinoma:

42
Tonsil, Thymus

Publications for Anus Basaloid Carcinoma

Articles related to Anus Basaloid Carcinoma:

# Title Authors Year
1
Spiradenocylindroma-like basaloid carcinoma of the anus and rectum: case report, including HPV studies and analysis of the CYLD gene mutations. ( 18806492 )
2008
2
Perianal basal cell carcinoma: a comparative histologic, immunohistochemical, and flow cytometric study with basaloid carcinoma of the anus. ( 8879301 )
1996

Variations for Anus Basaloid Carcinoma

Expression for Anus Basaloid Carcinoma

Search GEO for disease gene expression data for Anus Basaloid Carcinoma.

Pathways for Anus Basaloid Carcinoma

GO Terms for Anus Basaloid Carcinoma

Biological processes related to Anus Basaloid Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 8.96 PTGER4 TAC1
2 positive regulation of cytosolic calcium ion concentration GO:0007204 8.62 PTGER4 TAC1

Sources for Anus Basaloid Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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