MCID: ANS001
MIFTS: 24

Anus Basaloid Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Anus Basaloid Carcinoma

MalaCards integrated aliases for Anus Basaloid Carcinoma:

Name: Anus Basaloid Carcinoma 12 15
Basaloid Carcinoma of the Anus 12 70
Anal Basaloid Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7174
NCIt 50 C8256
UMLS 70 C0280470

Summaries for Anus Basaloid Carcinoma

MalaCards based summary : Anus Basaloid Carcinoma, also known as basaloid carcinoma of the anus, is related to basal cell carcinoma and transitional cell carcinoma. An important gene associated with Anus Basaloid Carcinoma is CYLD (CYLD Lysine 63 Deubiquitinase). The drugs nivolumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, skin and ovary, and related phenotype is integument.

Related Diseases for Anus Basaloid Carcinoma

Diseases related to Anus Basaloid Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 basal cell carcinoma 10.1
2 transitional cell carcinoma 10.1
3 rare tumor 10.1
4 basaloid squamous cell carcinoma 10.0
5 spiradenoma 10.0 KRT7 CYLD
6 apocrine sweat gland neoplasm 10.0 KRT7 CYLD
7 sweat gland benign neoplasm 10.0 KRT7 CYLD
8 rete testis neoplasm 10.0 PTGER4 KRT7
9 rete testis adenocarcinoma 10.0 PTGER4 KRT7
10 malignant syringoma 10.0 PTGER4 KRT7
11 large cell acanthoma 10.0 PTGER4 KRT7
12 pericardium cancer 10.0 PTGER4 KRT7
13 eccrine sweat gland cancer 10.0 PTGER4 KRT7
14 squamous papillomatosis 10.0 PTGER4 KRT7
15 thymus clear cell carcinoma 10.0 PTGER4 KRT7
16 peritoneal serous adenocarcinoma 10.0 PTGER4 KRT7
17 epididymis adenocarcinoma 10.0 PTGER4 KRT7
18 epididymis cancer 10.0 PTGER4 KRT7
19 sweat gland disease 10.0 KRT7 CYLD
20 cystic basal cell carcinoma 10.0 PTGER4 KRT7
21 intraductal breast benign neoplasm 10.0 PIK3CA KRT7
22 benign peritoneal mesothelioma 10.0 PTGER4 KRT7
23 bartholin's gland adenocarcinoma 10.0 PTGER4 KRT7
24 eccrine papillary adenoma 10.0 PIK3CA KRT7
25 borst-jadassohn intraepidermal carcinoma 10.0 PTGER4 KRT7
26 vulvar disease 10.0 PIK3CA KRT7
27 adenomatoid tumor 10.0 PTGER4 KRT7
28 hidradenoma 10.0 PIK3CA KRT7
29 female reproductive endometrioid cancer 10.0 PIK3CA KRT7
30 peritoneum cancer 10.0 PTGER4 KRT7
31 anus cancer 10.0 PIK3CA KRT7
32 epithelial-myoepithelial carcinoma 10.0 PIK3CA KRT7
33 myoepithelial carcinoma 10.0 PIK3CA KRT7
34 endocervical carcinoma 10.0 PIK3CA KRT7
35 salivary gland disease 10.0 KRT7 CYLD
36 mixed cell type cancer 9.9 PIK3CA KRT7
37 keratosis, seborrheic 9.9 PIK3CA KRT7
38 brooke-spiegler syndrome 9.9 KRT7 CYLD
39 rectum adenocarcinoma 9.9 PIK3CA KRT7
40 muir-torre syndrome 9.9 PTGER4 KRT7
41 tonsil cancer 9.9 PIK3CA KRT7
42 vulva cancer 9.9 PIK3CA KRT7
43 skin benign neoplasm 9.9 KRT7 CYLD
44 endocervical adenocarcinoma 9.9 PIK3CA KRT7
45 clear cell adenocarcinoma 9.9 PIK3CA KRT7
46 oropharynx cancer 9.9 PIK3CA KRT7
47 ovarian clear cell carcinoma 9.9 PIK3CA KRT7
48 ovary adenocarcinoma 9.9 PIK3CA KRT7
49 adenosquamous carcinoma 9.9 PIK3CA KRT7
50 carcinosarcoma 9.9 PIK3CA KRT7

Graphical network of the top 20 diseases related to Anus Basaloid Carcinoma:



Diseases related to Anus Basaloid Carcinoma

Symptoms & Phenotypes for Anus Basaloid Carcinoma

MGI Mouse Phenotypes related to Anus Basaloid Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 8.92 CYLD PIK3CA PTGER4 TAC1

Drugs & Therapeutics for Anus Basaloid Carcinoma

Drugs for Anus Basaloid Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 3 946414-94-4
2 Antineoplastic Agents, Immunological Phase 3
3
Fluorouracil Approved Phase 2 51-21-8 3385
4
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
5
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
6
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
7
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
8
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
9 Alkylating Agents Phase 2
10 Antibiotics, Antitubercular Phase 2
11 Mitomycins Phase 2
12 Anti-Bacterial Agents Phase 2
13 Immunosuppressive Agents Phase 2
14 Antimetabolites Phase 2
15 Immunologic Factors Phase 2
16 Antimitotic Agents Phase 2
17 Albumin-Bound Paclitaxel Phase 2
18 Tubulin Modulators Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Second UK Phase III Anal Cancer Trial: A Trial of Chemoradiation and Maintenance Therapy for Patients With Anal Cancer Completed NCT00025090 Phase 3 cisplatin;fluorouracil;mitomycin C
2 A Phase III Randomized Study of 5-Fluorouracil, Mitomycin-C, and Radiotherapy Versus 5-Fluorouracil, Cisplatin, and Radiotherapy in Carcinoma of the Anal Canal Completed NCT00003596 Phase 3 cisplatin;fluorouracil;mitomycin C
3 Intensification Therapy for Locally Advanced Epidermoid Cancer of the Anal Canal - Phase III Intergroup Study Completed NCT00003652 Phase 3 cisplatin;fluorouracil
4 A Randomized Phase III Study of Immune Checkpoint Inhibition With Chemotherapy in Treatment-Naïve Metastatic Anal Cancer Patients Recruiting NCT04444921 Phase 3 Carboplatin;Paclitaxel
5 A Randomized Phase III Study of Nivolumab After Combined Modality Therapy (CMT) in High Risk Anal Cancer Recruiting NCT03233711 Phase 3
6 A Phase II Evaluation of Dose-Painted Intensity-Modulated Radiation Therapy (IMRT) in Combination With 5-Fluorouracil (5-FU) and Mitomycin-C for Reduction of Acute Morbidity in Carcinoma of the Anal Canal Completed NCT00423293 Phase 2 fluorouracil;mitomycin C
7 Phase II Trial of Combined Modality Therapy Plus Cetuximab in HIV-Associated Anal Carcinoma Completed NCT00324415 Phase 2 cisplatin;fluorouracil
8 A Randomized Phase II Study De-Intensified ChemoRadiation for Early-Stage Anal Squamous Cell Carcinoma (DECREASE) Recruiting NCT04166318 Phase 2 Capecitabine;Fluorouracil;Mitomycin
9 Phase II Trial of Cetuximab Plus Cisplatin, 5- Fluorouracil and Radiation in Immunocompetent Patients With Anal Carcinoma Active, not recruiting NCT00316888 Phase 2 cisplatin;fluorouracil
10 InterAACT - An International Multicentre Open Label Randomised Phase II Advanced Anal Cancer Trial Comparing Cisplatin Plus 5-Fluorouracil Versus Carboplatin Plus Weekly Paclitaxel in Patients With Inoperable Locally Recurrent or Metastatic Disease Active, not recruiting NCT02560298 Phase 2 Capecitabine;Carboplatin;Cisplatin;Fluorouracil;Paclitaxel

Search NIH Clinical Center for Anus Basaloid Carcinoma

Genetic Tests for Anus Basaloid Carcinoma

Anatomical Context for Anus Basaloid Carcinoma

MalaCards organs/tissues related to Anus Basaloid Carcinoma:

40
Salivary Gland, Skin, Ovary, Testis, Thymus, Lung, Thyroid

Publications for Anus Basaloid Carcinoma

Articles related to Anus Basaloid Carcinoma:

# Title Authors PMID Year
1
CYLD-mutant cylindroma-like basaloid carcinoma of the anus: a genetically and morphologically distinct class of HPV-related anal carcinoma. 61
32461623 2020
2
Spiradenocylindroma-like basaloid carcinoma of the anus and rectum: case report, including HPV studies and analysis of the CYLD gene mutations. 61
18806492 2008
3
Perianal basal cell carcinoma. 61
11896421 2002
4
Conservative treatment of anorectal tumors. 61
9739380 1998
5
Perianal basal cell carcinoma: a comparative histologic, immunohistochemical, and flow cytometric study with basaloid carcinoma of the anus. 61
8879301 1996
6
Combined preoperative neoadjuvant radiotherapy and chemotherapy for anal and rectal cancer. 61
3085529 1986
7
Substance P plasma levels in pregnancy and in various clinical disorders. 61
478437 1979

Variations for Anus Basaloid Carcinoma

Expression for Anus Basaloid Carcinoma

Search GEO for disease gene expression data for Anus Basaloid Carcinoma.

Pathways for Anus Basaloid Carcinoma

GO Terms for Anus Basaloid Carcinoma

Biological processes related to Anus Basaloid Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 8.62 TAC1 PTGER4

Sources for Anus Basaloid Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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