MCID: ANS025
MIFTS: 30

Anus Benign Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Anus Benign Neoplasm

MalaCards integrated aliases for Anus Benign Neoplasm:

Name: Anus Benign Neoplasm 12 15
Anal Neoplasm 12 17
Neoplasm of Anus 12
Anus Neoplasms 43
Anal Tumors 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4551
MeSH 43 D001005
NCIt 49 C2877
SNOMED-CT 67 126849006
UMLS 71 C0003463

Summaries for Anus Benign Neoplasm

MalaCards based summary : Anus Benign Neoplasm, also known as anal neoplasm, is related to anal canal adenocarcinoma and anal canal carcinoma. An important gene associated with Anus Benign Neoplasm is MACROH2A2 (MacroH2A.2 Histone), and among its related pathways/superpathways is Necroptosis. The drugs Octreotide and Ipilimumab have been mentioned in the context of this disorder. Affiliated tissues include testes, lymph node and lung.

Related Diseases for Anus Benign Neoplasm

Graphical network of the top 20 diseases related to Anus Benign Neoplasm:



Diseases related to Anus Benign Neoplasm

Symptoms & Phenotypes for Anus Benign Neoplasm

Drugs & Therapeutics for Anus Benign Neoplasm

Drugs for Anus Benign Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 110)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 3 83150-76-9 383414 6400441
2
Ipilimumab Approved Phase 3 477202-00-9
3
Imiquimod Approved, Investigational Phase 3 99011-02-6 57469
4
Fluorouracil Approved Phase 2, Phase 3 51-21-8 3385
5
Cisplatin Approved Phase 2, Phase 3 15663-27-1 2767 441203 84093
6 Antineoplastic Agents, Hormonal Phase 3
7 interferons Phase 3
8 Adjuvants, Immunologic Phase 3
9 Anesthetics Phase 3
10 Alkylating Agents Phase 2, Phase 3
11 Anti-Bacterial Agents Phase 2, Phase 3
12 Antibiotics, Antitubercular Phase 2, Phase 3
13 Mitomycins Phase 2, Phase 3
14 Immunologic Factors Phase 2, Phase 3
15 Immunosuppressive Agents Phase 2, Phase 3
16 Antimetabolites Phase 2, Phase 3
17
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 43805 6857599 5310940 9887054
18
Cidofovir Approved Phase 2 113852-37-2 60613
19
Formaldehyde Approved, Vet_approved Phase 2 50-00-0 712
20
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
21
Irinotecan Approved, Investigational Phase 1, Phase 2 97682-44-5, 100286-90-6 60838
22
Valproic acid Approved, Investigational Phase 2 99-66-1 3121
23
Durvalumab Approved, Investigational Phase 2 1428935-60-7
24
Pomalidomide Approved Phase 2 19171-19-8
25
Panitumumab Approved, Investigational Phase 1, Phase 2 339177-26-3 50070211
26
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
27
Pembrolizumab Approved Phase 2 1374853-91-4
28
Atezolizumab Approved, Investigational Phase 1, Phase 2 1380723-44-3
29
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
30
Palonosetron Approved, Investigational Phase 2 135729-56-5, 119904-90-4 148211
31
Manganese Approved, Nutraceutical Phase 1, Phase 2 7439-96-5 27854
32 Antiviral Agents Phase 2
33 Anti-Retroviral Agents Phase 2
34 Anti-HIV Agents Phase 2
35 Pharmaceutical Solutions Phase 1, Phase 2
36 Interleukin-12 Phase 2
37 Psychotropic Drugs Phase 2
38 Anticonvulsants Phase 2
39 Immunoglobulins, Intravenous Phase 2
40 Antibodies, Monoclonal Phase 2
41 Immunoglobulin G Phase 2
42 Micronutrients Phase 1, Phase 2
43 Trace Elements Phase 1, Phase 2
44 Nutrients Phase 1, Phase 2
45 Angiogenesis Inhibitors Phase 2
46 Anti-Infective Agents Phase 2
47 Interferon-gamma Phase 2
48 taxane Phase 2
49 Vaccines Phase 1, Phase 2
50 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:

(show top 50) (show all 158)
# Name Status NCT ID Phase Drugs
1 Intensification Therapy for Locally Advanced Epidermoid Cancer of the Anal Canal - Phase III Intergroup Study Unknown status NCT00003652 Phase 3 cisplatin;fluorouracil
2 A Phase III Clinical Trial to Study the Tolerability and Immunogenicity of 9vHPV (V503), a Multivalent Human Papillomavirus (HPV) L1 Virus-Like Particle (VLP) Vaccine, in 16- to 26-Year-Old Men and 16- to 26-Year-Old Women Completed NCT01651949 Phase 3
3 A Randomized Clinical Trial of Infrared Coagulator (IRC) Ablation Versus Expectant Management of Intra-Anal High Grade Intraepithelial Neoplasia (HGAIN) in HIV-infected Adults Completed NCT01164722 Phase 3
4 A Randomized, Double Blind, Placebo-Controlled Phase III Study To Determine The Efficacy Of Sandostatin LAR® Depot (Octreotide Acetate) In Preventing Or Reducing The Severity Of Chemoradiation-Induced Diarrhea In Patients With Anal Or Rectal Cancer Completed NCT00075868 Phase 3 octreotide acetate
5 Second UK Phase III Anal Cancer Trial: A Trial of Chemoradiation and Maintenance Therapy for Patients With Anal Cancer Completed NCT00025090 Phase 3 cisplatin;fluorouracil;mitomycin C
6 A Phase III Randomized Study of 5-Fluorouracil, Mitomycin-C, and Radiotherapy Versus 5-Fluorouracil, Cisplatin, and Radiotherapy in Carcinoma of the Anal Canal Completed NCT00003596 Phase 3 cisplatin;fluorouracil;mitomycin C
7 Randomized Trial to Evaluate Effects of Deep Regional Hyperthermia in Patients With Anal Carcinoma Treated by Standard Radiochemotherapy Recruiting NCT02369939 Phase 3 Mitomycin C;5-Fluorouracil
8 A Randomized Non-inferiority Trial Evaluating the Length of Treatment With PD-1/PD-L1 Inhibitors in Patients With Advanced Solid Tumors Recruiting NCT04157985 Phase 3 Continue PD-1/PD-L1 Inhibitors treatment
9 Randomised Phase III Trial of Chemoradiotherapy With or Without Paclitaxel in Patients With Squamous-cell Anal Cancer Enrolling by invitation NCT02526953 Phase 3 Paclitaxel;Capecitabine;Capecitabine;Mitomycins;Mitomycins
10 ANCHOR Study: Anal Cancer/HSIL Outcomes Research Study Suspended NCT02135419 Phase 3 imiquimod;fluorouracil
11 Continuous Fluorouracil Plus Mitomycin C Versus Mitomycin C Plus Cisplatin As Chemotherapy Combination In Combined Radiochemotherapy For Locally Advanced Anal Cancer. A Phase II-III Study Terminated NCT00068744 Phase 2, Phase 3 cisplatin;fluorouracil;mitomycin C
12 An International Multicentre Open Label Randomised Phase II Advanced Anal Cancer Trial Comparing Cisplatin Plus 5 FU vs Carboplatin Plus Weekly Paclitaxel in Patients With Inoperable Locally Recurrent or Metastatic Disease Unknown status NCT02051868 Phase 2 Cisplatin;5-Fluorouracil (5-FU);Carboplatin;Paclitaxel
13 PHASE 2 STUDY OF ADXS11-001 IN SUBJECTS WITH PERSISTENT/RECURRENT, LOCO-REGIONAL OR METASTATIC SQUAMOUS CELL CARCINOMA OF THE ANORECTAL CANAL Completed NCT02399813 Phase 2 ADXS11-001
14 Phase II Study for Treatment of Anal HSIL Through Use of a Chinese Herbal Topical Cream Completed NCT00622440 Phase 2 AIJP (Arnebia Indigo Jade Pearl);Placebo
15 A Phase I/II Trial of SGN-00101 in the Treatment of High-Grade Anal Intraepithelial Neoplasia (AIN) in HIV-Positive Individuals Completed NCT00052897 Phase 1, Phase 2
16 A Phase II, Prospective, Open-label, Pilot Study of the Tolerability, Safety, and Efficacy of Argon Plasma Coagulation for the Treatment of Anal Intraepithelial Neoplasia Grade 2 or 3 in HIV-positive Men Having Sex With Men Completed NCT00428285 Phase 2
17 Improving Pelvic Cancer Patient Chemoradiotherapy Outcomes With FLT PET Imaging Completed NCT01717391 Phase 2 fluorothymidine F 18
18 Phase IIA Trial of 1% Topical Cidofovir for Treatment of High-Grade Perianal Squamous Intraepithelial Lesions in HIV-Infected Men and Women Completed NCT00550589 Phase 2 cidofovir
19 Phase II Trial of Combined Modality Therapy Plus Cetuximab in HIV-Associated Anal Carcinoma Completed NCT00324415 Phase 2 cisplatin;fluorouracil
20 AMC-072: Protective Effect of Quadrivalent Vaccine in Young HIV-Positive Males Who Have Sex With Males Completed NCT01209325 Phase 2
21 A Phase II Study of Capecitabine (Xeloda)/Oxaliplatin (Eloxatin) With Concomitant Radiotherapy (XRT), XELOX/RT in Squamous Cell Carcinoma of the Anal Canal Completed NCT00093379 Phase 2 Capecitabine;Oxaliplatin
22 A Phase II Evaluation of Dose-Painted Intensity-Modulated Radiation Therapy (IMRT) in Combination With 5-Fluorouracil (5-FU) and Mitomycin-C for Reduction of Acute Morbidity in Carcinoma of the Anal Canal Completed NCT00423293 Phase 2 fluorouracil;mitomycin C
23 Phase 2 Trial to Assess the Efficacy and Safety of Chemoradiation With 5-fluorouracil, Mytomicin C and Panitumumab as a Treatment for Anal Squamous Cell Carcinoma Completed NCT01285778 Phase 2 panitumumab, mytomicin C, 5-FU, radiation
24 A Phase II Study of Lymphodepletion Followed by Autologous Tumor-Infiltrating Lymphocytes and High-Dose Aldesleukin for Human Papillomavirus-Associated Cancers Completed NCT01585428 Phase 2 Fludarabine;Cyclophosphamide;Aldesleukin
25 A Phase I/II Study of T Cell Receptor Gene Therapy Targeting HPV-16 E6 for HPV-Associated Cancers Completed NCT02280811 Phase 1, Phase 2 Fludarabine;Cyclophosphamide;Aldesleukin
26 A Prospective Pilot Study to Evaluate the Feasibility of Intensity Modulated Proton Therapy in Reducing Toxicity in Anal Cancer Recruiting NCT03018418 Phase 2 Chemotherapy
27 Phase II Study of IMRT Radiotherapy Concurrent Chemothrerapy for Anal Cancer Recruiting NCT03381352 Phase 2 Capecitabine;Mitomycin C
28 A Phase 1/2a, Open-label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Anti-tumor Activity of PEN-866 in Patients With Advanced Solid Malignancies Recruiting NCT03221400 Phase 1, Phase 2 PEN-866 Sodium
29 A Randomized Phase II Study of Nivolumab After Combined Modality Therapy (CMT) in High Risk Anal Cancer Recruiting NCT03233711 Phase 2
30 A Multicenter Phase 2 Clinical Trial of Pembrolizumab in Refractory Metastatic Anal Cancer Recruiting NCT02919969 Phase 2 Pembrolizumab
31 A Non-comparative Randomized 2:1 Phase II Study of Docetaxel, Cisplatin, and 5-fluorouracil in Combination or Not With Atezolizumab in Patients With Metastatic or Unresectable Locally Advanced Squamous Cell Anal Carcinoma Recruiting NCT03519295 Phase 2 MPDL3280A;mDCF
32 Phase II Study of SIB-IMRT in Combination With 5-FU and Mitomycin-C Among Patients With Locally Advanced Anal Canal Cancer: Efficacy, Safety and Quality of Life Recruiting NCT02701088 Phase 2 5Fluorouracile and Mitomycin-C
33 The LATENT Trial: Lytic Activation To Enhance Neoantigen-directed Therapy A Study to Evaluate the Feasibility and Efficacy of the Combined Use of Avelumab With Valproic Acid for the Treatment of Virus-associated Cancer Recruiting NCT03357757 Phase 2 Valproic Acid
34 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRXâ„¢ Anorectal Wand Recruiting NCT03302858 Phase 2
35 A Randomized Phase II Study De-Intensified ChemoRadiation for Early-Stage Anal Squamous Cell Carcinoma (DECREASE) Recruiting NCT04166318 Phase 2 Capecitabine;Fluorouracil;Mitomycin
36 Radiochemotherapy +/- Durvalumab for Locally-advanced Anal Carcinoma. Recruiting NCT04230759 Phase 2 Chemotherapy;Durvalumab
37 A Phase 2, Open-Label Study to Evaluate Efficacy of Combination Treatment With MEDI0457 (INO-3112) and Durvalumab (MEDI4736) in Patients With Recurrent/Metastatic Human Papilloma Virus Associated Cancers Recruiting NCT03439085 Phase 2
38 Linear Energy Transfer (LET)-Optimized Intensity Modulated Proton Therapy (IMPT) as a Component of Definitive Chemoradiation for Newly Diagnosed Squamous Cell Carcinoma of the Anal Canal: A Feasibility Trial Recruiting NCT03690921 Phase 2 Cisplatin;Fluorouracil
39 Phase I/II Trial of Combination Immunotherapy in Subjects With Advanced HPV Associated Malignancies Recruiting NCT04287868 Phase 1, Phase 2
40 Phase II Trial of M7824 in Subjects With HPV Associated Malignancies Recruiting NCT03427411 Phase 2 M7824
41 A Randomized Phase II Study of the Administration of Prebiotics and Probiotics During Definitive Treatment With Chemotherapy-radiotherapy for Patients With Squamous Cell Carcinoma of the Anal Canal (BISQUIT) Recruiting NCT03870607 Phase 2
42 A Phase 1 Trial for Patients With Newly Diagnosed Anal Cancer Treated With Concurrent Radiation Therapy, 5FU, Mitomycin and BMX-001 Recruiting NCT03386500 Phase 1, Phase 2 BMX-001
43 A Phase 2, Open Label, Study of VGX-3100 Delivered Intramuscularly (IM) Followed by Electroporation (EP) for the Treatment of HPV-16 and/or HPV-18 Related Anal or Anal/Peri-Anal, High Grade Squamous Intraepithelial Lesion (HSIL), (AIN2, AIN3, PAIN2, PAIN3) in Individuals That Are Seronegative for Human Immunodeficiency Virus (HIV)-1/2 Active, not recruiting NCT03499795 Phase 2
44 Study of Pomalidomide in Anal Cancer Precursors (SPACE): a Phase 2 Study of Immunomodulation in People With Persistent HPV-associated High Grade Squamous Intraepithelial Lesions Active, not recruiting NCT03113942 Phase 2 Pomalidomide 2 MG Oral Capsule [Pomalyst]
45 Phase I-II on Radiochemotherapy Combined With Panitumumab in the Treatment of Localised Epidermoid Carcinoma of the Anus Active, not recruiting NCT01581840 Phase 1, Phase 2 radiochemotherapy;Panitumumab
46 A Phase Ib/II Trial To Test The Safety And Efficacy Of Vaccination With HPV16-E711-19 Nanomer For The Treatment Of Incurable HPV 16-Related Oropharyngeal, Cervical And Anal Cancer In HLA-A*02 Positive Patients Active, not recruiting NCT02865135 Phase 1, Phase 2 DPX-E7 vaccine
47 InterAACT - An International Multicentre Open Label Randomised Phase II Advanced Anal Cancer Trial Comparing Cisplatin Plus 5-Fluorouracil Versus Carboplatin Plus Weekly Paclitaxel in Patients With Inoperable Locally Recurrent or Metastatic Disease Active, not recruiting NCT02560298 Phase 2 Capecitabine;Carboplatin;Cisplatin;Fluorouracil;Paclitaxel
48 Randomized Phase 2 Trial of Cetuximab and Avelumab or Avelumab Alone for Unresectable, Locally Advanced or Metastatic Squamous Cell Anal Carcinoma (SCCAC) Progressed After at Least One Line of Systemic Treatment Active, not recruiting NCT03944252 Phase 2 Avelumab;Cetuximab
49 A Multicenter Observational and Feasibility Study of Excision of Superficially Invasive Squamous Cell Carcinoma (SISCCA) of the Anal Canal and Perianus in HIV-Infected Persons Active, not recruiting NCT02437851 Phase 2
50 Assessment of the Clinical Value of a Docetaxel, Cisplatin and 5-fluorouracil (DCF) Strategy Adapted to Patients for the Management of Metastatic or Locally Advanced Anal Resistant Radiochemotherapy Squamous Cell Anal Carcinoma. Active, not recruiting NCT02402842 Phase 2 Docetaxel, Cisplatin and 5-Fluorouracil

Search NIH Clinical Center for Anus Benign Neoplasm

Cochrane evidence based reviews: anus neoplasms

Genetic Tests for Anus Benign Neoplasm

Anatomical Context for Anus Benign Neoplasm

MalaCards organs/tissues related to Anus Benign Neoplasm:

40
Testes, Lymph Node, Lung, Cervix, Liver, Pancreas, Breast

Publications for Anus Benign Neoplasm

Articles related to Anus Benign Neoplasm:

# Title Authors PMID Year
1
A rare case of perianal granular cell tumor: case report and literature review. 61
28603602 2017
2
Pathology of Anal Cancer. 61
27889037 2017
3
Loss of histone variant macroH2A2 expression associates with progression of anal neoplasm. 61
26658220 2016
4
[Screening of intraepithelial anal neoplasm]. 61
24210980 2014
5
[Anal endosonography in the diagnosis of anal neoplasm]. 61
12557448 2002
6
[Anal neoplasm. Considerations on 100 cases]. 61
5614746 1967

Variations for Anus Benign Neoplasm

Expression for Anus Benign Neoplasm

Search GEO for disease gene expression data for Anus Benign Neoplasm.

Pathways for Anus Benign Neoplasm

Pathways related to Anus Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.03 MACROH2A2 H2AB2 H2AB1

GO Terms for Anus Benign Neoplasm

Cellular components related to Anus Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromosome GO:0005694 9.46 H2AB1 H2AB2 H2BW1 MACROH2A2
2 nuclear nucleosome GO:0000788 9.26 H2AB1 H2AB2
3 transcriptionally active chromatin GO:0035327 8.96 H2AB1 H2AB2
4 nucleosome GO:0000786 8.92 MACROH2A2 H2BW1 H2AB2 H2AB1

Biological processes related to Anus Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin silencing GO:0006342 9.13 MACROH2A2 H2AB2 H2AB1
2 nucleosome assembly GO:0006334 8.92 MACROH2A2 H2BW1 H2AB2 H2AB1

Molecular functions related to Anus Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 8.92 MACROH2A2 H2BW1 H2AB2 H2AB1

Sources for Anus Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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