Anus Cancer

Categories: Rare diseases, Gastrointestinal diseases, Cancer diseases

Aliases & Classifications for Anus Cancer

MalaCards integrated aliases for Anus Cancer:

Name: Anus Cancer 12 15
Anal Cancer 12 53 43
Anus Neoplasms 44 73
Anus Neoplasm 12 15
Malignant Neoplasm of Anus 73
Malignant Anal Tumor 12
Cancer of the Anus 53
Neoplasm of Anus 12
Anal Carcinoma 73
Anal Neoplasm 12
Anal Tumors 12


Summaries for Anus Cancer

NIH Rare Diseases : 53 Anal cancer is a rare form of cancer that occurs due to abnormal and uncontrolled cell growth in the anus. Signs and symptoms of the condition include rectal bleeding; a lump in or near the anus; anal pain; itching; changes in bowel habits; and/or swollen lymph nodes. In most cases, the underlying cause of anal cancer is unknown. There appears to be a link between anal cancer and the human papillomavirus (HPV) infection. Other risk factors for anal cancer include HIV infection, sexual activity, smoking, and a weakened immune system. The best treatment options for anal cancer depend on many factors including the stage of the condition, the location of the tumor and if there are associated conditions (i.e. HIV) but may include surgery, chemotherapy, and radiation therapy.

MalaCards based summary : Anus Cancer, also known as anal cancer, is related to anal canal squamous cell carcinoma and anal canal adenocarcinoma, and has symptoms including pruritus ani, abdominal pain and constipation. An important gene associated with Anus Cancer is SERPINB3 (Serpin Family B Member 3). The drugs Gardasil and Oxaliplatin have been mentioned in the context of this disorder. Affiliated tissues include the anus, testes and lymph node, and related phenotype is homeostasis/metabolism.

MedlinePlus : 43 The anus is where stool leaves your body when you go to the bathroom. It is made up of your outer layers of skin and the end of your large intestine. Anal cancer is a disease in which cancer cells form in the tissues of the anus. Anal cancer is rare. It is more common in smokers and people over 50. You are also at higher risk if you have HPV, have anal sex, or have many sexual partners. Symptoms include bleeding, pain, or lumps in the anal area. Anal itching and discharge can also be signs of anal cancer. Doctors use tests that examine the anus to diagnose anal cancer. They include a physical exam, endoscopy, ultrasound, and biopsy. Treatments include radiation therapy, chemotherapy, and surgery. NIH: National Cancer Institute

Disease Ontology : 12 A large intestine cancer that is located in the anus.

Wikipedia : 76 Anal cancer is a cancer (malignant tumor) which arises from the anus, the distal opening of the... more...

Related Diseases for Anus Cancer

Diseases related to Anus Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 anal canal squamous cell carcinoma 30.4 CDKN2A KRT5 SERPINB3
2 anal canal adenocarcinoma 30.0 CDX2 KRAS KRT7
3 anus sarcoma 10.9
4 hemorrhoid 10.9
5 vulva squamous cell carcinoma 10.8 CDKN2A SERPINB3
6 endocervical carcinoma 10.7 CDKN2A KRT7
7 vulval paget's disease 10.7 CDKN2A KRT7
8 adenoid basal cell carcinoma 10.7 CDKN2A KRT7
9 bladder carcinoma in situ 10.7 CDKN2A KRT7
10 glycogen-rich clear cell breast carcinoma 10.7 CDKN2A KRT7
11 well-differentiated liposarcoma 10.7 CDKN2A KRT7
12 ovary neuroendocrine neoplasm 10.7 CDX2 KRT7
13 vaginal benign neoplasm 10.6 CDX2 KRT7
14 appendix adenocarcinoma 10.6 CDX2 KRT7
15 vaginal adenoma 10.6 CDX2 KRT7
16 vaginal tubulovillous adenoma 10.6 CDX2 KRT7
17 mucinous adenofibroma 10.6 CDX2 KRT7
18 anus adenocarcinoma 10.6 CDX2 KRT7
19 glandular cystitis 10.6 CDX2 KRT7
20 keratinizing squamous cell carcinoma 10.6 CDKN2A KRT5
21 optic nerve sheath meningioma 10.6 CDKN2A KRT5
22 epithelial predominant wilms' tumor 10.6 CDX2 KRT7
23 balloon cell malignant melanoma 10.6 KRT5 KRT7
24 benign breast adenomyoepithelioma 10.6 KRT5 KRT7
25 ovarian mucinous adenocarcinoma 10.6 CDX2 KRT7
26 thymus adenocarcinoma 10.6 CDX2 KRT7
27 gastric diffuse adenocarcinoma 10.6 CDX2 KRT7
28 sensory organ benign neoplasm 10.6 KRT5 KRT7
29 bile duct mucoepidermoid carcinoma 10.6 KRT5 KRT7
30 bladder adenocarcinoma 10.6 CDX2 KRT7
31 middle ear adenoma 10.6 KRT5 KRT7
32 chronic cystitis 10.6 CDX2 KRT7
33 basaloid squamous cell carcinoma 10.6 CDKN2A KRT7
34 large cell acanthoma 10.6 KRT5 KRT7
35 mucinous ovarian cystadenoma 10.6 CDX2 KRT7
36 papillary adenoma 10.6 KRT5 KRT7
37 apocrine sweat gland neoplasm 10.5 KRT5 KRT7
38 schneiderian carcinoma 10.5 CDKN2A KRT5
39 apocrine adenocarcinoma 10.5 KRT5 KRT7
40 ampulla of vater adenocarcinoma 10.5 CDX2 KRT7
41 cervical clear cell adenocarcinoma 10.5 CDKN2A KRT5
42 inverted papilloma 10.5 CDKN2A KRT7 SERPINB3
43 vulva cancer 10.5 CDKN2A KRT7 SERPINB3
44 malignant biphasic mesothelioma 10.5 KRT5 KRT7
45 breast adenomyoepithelioma 10.5 KRT5 KRT7
46 breast myoepithelial neoplasm 10.5 KRT5 KRT7
47 ovarian mucinous neoplasm 10.5 CDX2 KRT7
48 cystic teratoma 10.5 CDX2 KRT7
49 atypical choroid plexus papilloma 10.4 KRT5 KRT7
50 horner's syndrome 10.4 CD6 KRT7

Comorbidity relations with Anus Cancer via Phenotypic Disease Network (PDN):

Acute Cystitis Deficiency Anemia
Rectal Neoplasm

Graphical network of the top 20 diseases related to Anus Cancer:

Diseases related to Anus Cancer

Symptoms & Phenotypes for Anus Cancer

UMLS symptoms related to Anus Cancer:

pruritus ani, abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

MGI Mouse Phenotypes related to Anus Cancer:

# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.28 CARTPT CD6 CDKN2A CDX2 KRAS KRT7

Drugs & Therapeutics for Anus Cancer

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
Gardasil 18 49 quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine Merck June 2006

Drugs for Anus Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 145)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Oxaliplatin Approved, Investigational Phase 4,Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
2 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
3 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
4 Pharmaceutical Solutions Phase 4,Not Applicable
5 Antibodies Phase 4,Phase 2,Phase 1,Not Applicable
6 Immunoglobulins Phase 4,Phase 2,Phase 1,Not Applicable
7 Cola Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
Capecitabine Approved, Investigational Phase 3,Phase 2,Phase 1 154361-50-9 60953
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
Fluorouracil Approved Phase 3,Phase 2,Phase 1,Early Phase 1 51-21-8 3385
Octreotide Approved, Investigational Phase 3 83150-76-9 383414 6400441
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
Imiquimod Approved, Investigational Phase 3 99011-02-6 57469
15 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
16 interferons Phase 3,Phase 2,Phase 1
17 Albumin-Bound Paclitaxel Phase 3,Phase 2,Phase 1
18 Anesthetics Phase 3,Phase 1,Not Applicable
19 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Early Phase 1
20 Antimetabolites Phase 3,Phase 2,Phase 1,Early Phase 1
21 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1,Early Phase 1
22 Antimitotic Agents Phase 3,Phase 2,Phase 1
23 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
24 Analgesics Phase 3,Phase 2
25 Alkylating Agents Phase 3,Phase 2,Phase 1,Early Phase 1
26 Central Nervous System Depressants Phase 3,Phase 2
27 Adjuvants, Anesthesia Phase 3
28 Adjuvants, Immunologic Phase 3,Phase 1
29 Mitomycins Phase 3,Phase 2,Phase 1,Early Phase 1
30 Gastrointestinal Agents Phase 3
31 Narcotics Phase 3
32 Analgesics, Opioid Phase 3
33 Anesthetics, General Phase 3
34 Anesthetics, Intravenous Phase 3
35 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
36 Peripheral Nervous System Agents Phase 3,Phase 2
37 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1,Early Phase 1
38 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1,Early Phase 1
39 Antineoplastic Agents, Hormonal Phase 3
40 Interferon Inducers Phase 3
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 498142 38904
Ritonavir Approved, Investigational Phase 2 155213-67-5 392622
Indinavir Approved Phase 2 150378-17-9 5362440
Cetuximab Approved Phase 2,Phase 1 205923-56-4 56842117 2333
Vidarabine Approved, Investigational Phase 1, Phase 2,Phase 2 24356-66-9 32326 21704
Fludarabine Approved Phase 1, Phase 2,Phase 2 21679-14-1, 75607-67-9 30751
Menthol Approved Phase 2,Not Applicable 2216-51-5 16666
Formaldehyde Approved, Vet_approved Phase 2 50-00-0 712
Cidofovir Approved Phase 2 113852-37-2 60613
Cyclophosphamide Approved, Investigational Phase 1, Phase 2,Phase 2 50-18-0, 6055-19-2 2907

Interventional clinical trials:

(show top 50) (show all 185)
# Name Status NCT ID Phase Drugs
1 Relationship Between Platinum Levels in the Blood and Neurotoxicity in Patients Who Are Receiving Oxaliplatin for Gastrointestinal Cancer Unknown status NCT00274885 Phase 4 oxaliplatin
2 Transmission Reduction and Prevention With HPV Vaccination (TRAP-HPV) Study Recruiting NCT01824537 Phase 4
3 Scientific Evaluation of One or Two Doses of the Bivalent or Nonavalent Prophylactic HPV Vaccines Recruiting NCT03180034 Phase 4
4 Immunogenicity and Safety of Human Papilloma Virus Vaccine in Solid Organ Transplant Recipients Active, not recruiting NCT02624349 Phase 4 Quadravalent human papillomavirus vaccine
5 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Unknown status NCT00003652 Phase 3 cisplatin;fluorouracil
6 Radiation Therapy Plus Fluorouracil With or Without Additional Chemotherapy in Treating Patients With Primary Anal Cancer Completed NCT00025090 Phase 3 cisplatin;fluorouracil;mitomycin C
7 Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Completed NCT00003596 Phase 3 cisplatin;fluorouracil;mitomycin C
8 Infrared Coagulator Ablation or Observation in Preventing Anal Cancer in HIV-Positive Patients With Anal Neoplasia Completed NCT01164722 Phase 3
9 An Investigational Study of Gardasil™ (qHPV Vaccine) in Reducing the Incidence of Anogenital Warts in Young Men (V501-020) Completed NCT00090285 Phase 3
10 Multivalent HPV (Human Papillomavirus) Vaccine Study in 16- to 26-Year Old Men and Women (V503-003) Completed NCT01651949 Phase 3
11 Octreotide in Preventing or Reducing Diarrhea in Patients Receiving Chemoradiotherapy for Anal or Rectal Cancer Completed NCT00075868 Phase 3 octreotide acetate
12 Quadrivalent HPV Vaccine to Prevent Anal HPV in HIV-infected Men and Women Completed NCT01461096 Phase 3
13 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
14 Topical or Ablative Treatment in Preventing Anal Cancer in Patients With HIV and Anal High-Grade Squamous Intraepithelial Lesions Recruiting NCT02135419 Phase 3 imiquimod;fluorouracil
15 Effects of Deep Regional Hyperthermia in Patients With Anal Carcinoma Treated by Standard Radiochemotherapy Recruiting NCT02369939 Phase 3 Mitomycin C;5-Fluorouracil
16 Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery Recruiting NCT02997553 Phase 3 Indocyanine green;Technetium99
17 Efficacy Study of Chemoradiotherapy With or Without Paclitaxel in Squamous-cell Anal Carcinoma Patients Enrolling by invitation NCT02526953 Phase 3 Paclitaxel;Capecitabine;Capecitabine;Mitomycins;Mitomycins
18 Radiation Therapy, Mitomycin, and Either Fluorouracil or Cisplatin in Treating Patients With Locally Advanced Anal Cancer Terminated NCT00068744 Phase 2, Phase 3 cisplatin;fluorouracil;mitomycin C
19 Radiation Therapy, Cisplatin, Fluorouracil, and Cetuximab in Treating Patients With Locally Advanced Anal Cancer Unknown status NCT00955240 Phase 2 cisplatin;fluorouracil
20 International Multicentre Study in Advanced Anal Cancer Comparing Cisplatin Plus 5 FU vs Carboplatin Plus Weekly Paclitaxel Unknown status NCT02051868 Phase 2 Cisplatin;5-Fluorouracil (5-FU);Carboplatin;Paclitaxel
21 A Phase II Study to Assess Acute Toxicity and Quality of Life of Patients With Carcinoma of the Anal Canal Receiving Chemotherapy and Radiation Using Helical Tomotherapy Unknown status NCT00754078 Phase 2
22 External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
23 Combined Modality Therapy for Patients With With HIV and Stage I, Stage II, or Stage III Anal Cancer Completed NCT00324415 Phase 2 cisplatin;fluorouracil
24 SGN-00101 in Preventing Anal Cancer in Patients With HIV Who Have Anal Neoplasia Completed NCT00052897 Phase 1, Phase 2
25 Intensity-Modulated Radiation Therapy, Fluorouracil, and Mitomycin C in Treating Patients With Invasive Anal Cancer Completed NCT00423293 Phase 2 fluorouracil;mitomycin C
26 Capecitabine, Oxaliplatin, and Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Completed NCT00093379 Phase 2 Capecitabine;Oxaliplatin
27 Cidofovir in Treating HIV-Infected Patients With High-Grade Squamous Intraepithelial Lesions of the Skin Near the Anus Completed NCT00550589 Phase 2 cidofovir
28 Vectibix for the Treatment of Anal Cancer Completed NCT01285778 Phase 2 panitumumab, mytomicin C, 5-FU, radiation
29 Treatment of Anal High-grade Squamous Intraepithelial Lesions (HSIL) Through Use of a Chinese Herbal Topical Cream Completed NCT00622440 Phase 2 AIJP (Arnebia Indigo Jade Pearl);Placebo
30 Tolerability, Safety, & Efficacy of Argon Plasma Coagulation to Treat Anal Intraepithelial Neoplasia in HIV-Positive Men Completed NCT00428285 Phase 2
31 Vaccine Therapy in Preventing Human Papillomavirus Infection in Young HIV-Positive Male Patients Who Have Sex With Males Completed NCT01209325 Phase 2
32 Erlotinib in Treating Patients With Advanced Kidney Cancer Completed NCT00045487 Phase 2 OSI-774
33 A Study of Substitution of 5-FU (Fluorouracil) by Capecitabine in Scheme of Chemo-radiotherapy in Patients With Squamous Cell Carcinoma of the Anal Canal. Completed NCT01941966 Phase 2 Capecitabine;Mitomycins
34 T Cell Receptor Immunotherapy Targeting HPV-16 E6 for HPV-Associated Cancers Completed NCT02280811 Phase 1, Phase 2 Fludarabine;Cyclophosphamide;Aldesleukin
35 Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Human Papillomavirus-Associated Cancers Completed NCT01585428 Phase 2 Fludarabine;Cyclophosphamide;Aldesleukin
36 [F-18] Fluorothymidine PET/CT Imaging for Pelvic Cancers Completed NCT01717391 Phase 2 fluorothymidine F 18
37 Oral Rigosertib for Squamous Cell Carcinoma Completed NCT01807546 Phase 2 rigosertib
38 Pembrolizumab in Refractory Metastatic Anal Cancer Recruiting NCT02919969 Phase 2 Pembrolizumab
39 Proton Therapy in Reducing Toxicity in Anal Cancer Recruiting NCT03018418 Phase 2 Chemotherapy
40 Trial To Test Safety And Efficacy Of Vaccination For Incurable HPV 16-Related Oropharyngeal, Cervical And Anal Cancer Recruiting NCT02865135 Phase 1, Phase 2 DPX-E7 vaccine;Cyclophosphamide
41 Study of IMRT Radiotherapy Concurrent Chemothrerapy for Anal Cancer Recruiting NCT03381352 Phase 2 Capecitabine;Mitomycin C
42 A Study of mDCF in Combination or Not With Atezolizumab in Advanced Squamous Cell Anal Carcinoma Recruiting NCT03519295 Phase 2 MPDL3280A;mDCF
43 Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer Recruiting NCT03233711 Phase 2
44 VGX-3100 Delivered Intramuscularly (IM) Followed by Electroporation (EP) for the Treatment of HPV-16 and/or HPV-18 Related Anal or Anal/Peri-Anal, High Grade Squamous Intraepithelial Lesion (HSIL) in Individuals Seronegative for Human Immunodeficiency Vir Recruiting NCT03499795 Phase 2
45 M7824 in Subjects With HPV Associated Malignancies Recruiting NCT03427411 Phase 2 M7824
46 Study of SIB-IMRT in Combination With 5-FU and Mitomycin-C Among Patients With Locally Advanced Anal Canal Cancer: Efficacy, Safety and Quality of Life Recruiting NCT02701088 Phase 2 5Fluorouracile and Mitomycin-C
47 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRX™ Anorectal Wand Recruiting NCT03302858 Phase 2
48 Avelumab With Valproic Acid in Virus-associated Cancer Recruiting NCT03357757 Phase 2 Valproic Acid
49 Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158) Recruiting NCT02628067 Phase 2
50 A Phase 1/2 Trial of SRA737 in Subjects With Advanced Cancer Recruiting NCT02797964 Phase 1, Phase 2 SRA737

Search NIH Clinical Center for Anus Cancer

Cochrane evidence based reviews: anus neoplasms

Genetic Tests for Anus Cancer

Anatomical Context for Anus Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Anus Cancer:

The Anus

MalaCards organs/tissues related to Anus Cancer:

Testes, Lymph Node, Skin, Lung, Liver, Breast, Kidney

Publications for Anus Cancer

Articles related to Anus Cancer:

(show all 20)
# Title Authors Year
Mutational analysis of anal cancers demonstrates frequent PIK3CA mutations associated with poor outcome after salvage abdominoperineal resection. ( 27219019 )
Intensified intensity-modulated radiotherapy in anal cancer with prevalent HPV p16 positivity. ( 26457030 )
EGFR, KRAS, BRAF, and PIK3CA characterization in squamous cell anal cancer. ( 24122611 )
Influence of human papillomavirus and p16(INK4a) on treatment outcome of patients with anal cancer. ( 25465729 )
Can radiobiological parameters derived from squamous cell carcinoma of the head and neck be used to predict local control in anal cancer treated with chemoradiation? ( 23239699 )
Time trends in colon, rectum and anus cancer mortality between 1955 and 2008 in Japan, USA and Europe based on the WHO mortality database. ( 21875940 )
[Radiochemotherapy for locally advanced anal cancer]. ( 20431309 )
Screening for HIV-associated anal cancer: correlation of HPV genotypes, p16, and E6 transcripts with anal pathology. ( 19567510 )
Comparison of time trends in colon, rectum and anus cancer incidence (1973-2002) in Asia, from 'Cancer Incidence in Five Continents, Vols IV-IX'. ( 19233893 )
Lack of correlation between p53 codon 72 polymorphism and anal cancer risk. ( 19777616 )
Cetuximab-based treatment of metastatic anal cancer: correlation of response with KRAS mutational status. ( 19923868 )
Radiation dose associated with local control in advanced anal cancer: retrospective analysis of 129 patients. ( 18501453 )
FHIT oncosuppressor gene expression profile in human anal cancers. ( 17393360 )
Prognostic significance of Cyclin A in epidermoid anal cancer. ( 16865241 )
The role of macrophages in angiogenesis. Comparison between HIV+ and HIV- populations with anal dysplasia and anal cancer. ( 15868898 )
Anal cancer: an HIV-associated cancer. ( 12852659 )
Proliferation and p53 expression in anal cancer precursor lesions. ( 12926152 )
Expression profile of epidermal differentiation complex genes in normal and anal cancer cells. ( 11713581 )
Expression analysis and mutational screening of the epithelium-specific ets gene-1 (ESE-1) in patients with squamous anal cancer. ( 10891534 )
Anorectal miscellany: pilonidal disease, anal cancer, Bowen's and Paget's diseases, foreign bodies, and hidradenitis suppurativa. ( 9922300 )

Variations for Anus Cancer

Expression for Anus Cancer

Search GEO for disease gene expression data for Anus Cancer.

Pathways for Anus Cancer

GO Terms for Anus Cancer

Biological processes related to Anus Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cellular senescence GO:2000774 8.62 CDKN2A KRAS

Sources for Anus Cancer

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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