Aliases & Classifications for Anus Disease

MalaCards integrated aliases for Anus Disease:

Name: Anus Disease 12 15 17
Anus Diseases 43 71
Anal Fissure 12 71
Nontraumatic Tear of Anus 12
Anal Fissure and Fistula 12
Abnormality of the Anus 6
Solitary Anal Ulcer 12
Fissure in Ano 12
Anal Disorders 42
Ulcer of Anus 12
Anal Disease 12
Anal Ulcer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3128
MeSH 43 D001004
NCIt 49 C26695
SNOMED-CT 67 32110003
ICD10 32 K60.2
UMLS 71 C0003462 C0016167

Summaries for Anus Disease

MedlinePlus : 42 The anus is the opening of the rectum through which stool passes out of your body. Problems with the anus are common. They include hemorrhoids, abscesses, fissures (cracks), and cancer. You may be embarrassed to talk about your anal troubles. But it is important to let your doctor know, especially if you have pain or bleeding. The more details you can give about your problem, the better your doctor will be able to help you. Treatments vary depending on the particular problem. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Anus Disease, also known as anus diseases, is related to genital herpes and exanthem, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Anus Disease is FREM2 (FRAS1 Related Extracellular Matrix 2), and among its related pathways/superpathways are Colorectal Cancer Metastasis and Phagocytosis of Microbes. The drugs Acetylcholine and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and t cells.

Wikipedia : 74 The anus (from Latin anus meaning "ring", "circle") is an opening at the opposite end of an animal's... more...

Related Diseases for Anus Disease

Diseases related to Anus Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 372)
# Related Disease Score Top Affiliating Genes
1 genital herpes 31.1 CD8A CD4 CCR6
2 exanthem 31.0 H2AC18 CD8A CD4 CCR6
3 allergic hypersensitivity disease 30.9 TLR4 H2AC18 CD4 CCR6
4 anal squamous cell carcinoma 30.8 TP53 H2AC18 CDKN2A APOLD1
5 perinatal necrotizing enterocolitis 30.7 TLR8 TLR7 TLR4 CCR6
6 histoplasmosis 30.7 CD8A CD4 CCR6
7 syphilis 30.5 CD8A CD4 CCR6 CARTPT
8 cellulitis 30.5 CD8A CD4 CCR6
9 leukemia, acute myeloid 30.3 TP53 H2AC18 CDKN2A CD8A CD4 CCR6
10 anogenital venereal wart 29.8 TP53 TLR8 TLR7 TLR4 LINC01191 H2AC18
11 anus cancer 29.7 TP53 SERPINB3 LINC01191 H2AC18 GP5 CDKN2A
12 rectal disease 28.5 TP53 TLR8 TLR7 TLR4 TEF SERPINB3
13 ulcer of anus and rectum 12.6
14 constipation 11.6
15 opitz-kaveggia syndrome 11.0
16 anal fistula 11.0
17 anal margin squamous cell carcinoma 10.7 CDKN2A APOLD1
18 cork-handlers' disease 10.7 CD8A CD4
19 syphilitic meningitis 10.7 CD8A CD4
20 autoimmune vasculitis 10.7 H2AC18 CD4 CCR6
21 ventilation pneumonitis 10.7 CD8A CD4
22 adult acute lymphocytic leukemia 10.7 CD8A CD4 CCR6
23 anus benign neoplasm 10.7 H2AC18 CDKN2A APOLD1
24 diffuse infiltrative lymphocytosis syndrome 10.7 CD8A CD4
25 anal margin carcinoma 10.7 CDKN2A APOLD1
26 spongiotic dermatitis 10.7 CD8A CD4 CCR6
27 mucocutaneous leishmaniasis 10.7 H2AC18 CD8A CD4
28 geotrichosis 10.7 CD4 CARTPT
29 autoimmune lymphoproliferative syndrome, type iia 10.7 CD8A CD4
30 west nile encephalitis 10.7 TLR7 CD8A CD4
31 blastomycosis 10.7 CD8A CD4 CCR6
32 orchitis 10.7 H2AC18 CD8A CD4
33 autoimmune disease of cardiovascular system 10.7 CD8A CD4 CCR6
34 dacryoadenitis 10.7 CD8A CD4 CCR6
35 vulvar intraepithelial neoplasia 10.7 TP53 CDKN2A
36 central nervous system vasculitis 10.7 CD8A CD4 CCR6
37 common wart 10.7 TP53 TLR7 CD4
38 chromosome 14q11-q22 deletion syndrome 10.6 CD8A CD4
39 autoimmune glomerulonephritis 10.6 CD8A CD4 CCR6
40 acute myocarditis 10.6 H2AC18 CD8A CD4
41 diabetes mellitus, insulin-dependent, 23 10.6 CD8A CD4
42 autoimmune disease of eyes, ear, nose and throat 10.6 CD8A CD4 CCR6
43 thrombocytopenia due to platelet alloimmunization 10.6 CD8A CD4 CCR6
44 tularemia 10.6 TLR4 CD8A CD4
45 childhood type dermatomyositis 10.6 CD8A CD4 CCR6
46 primary thrombocytopenia 10.6 CD8A CD4 CCR6
47 inverted follicular keratosis 10.6 SALL1 GP5
48 blepharitis 10.6 CD8A CD4 CCR6
49 mast cell neoplasm 10.6 H2AC18 CD8A CD4
50 ovarian squamous cell carcinoma 10.6 LINC01191 CDKN2A APOLD1

Comorbidity relations with Anus Disease via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease

Graphical network of the top 20 diseases related to Anus Disease:



Diseases related to Anus Disease

Symptoms & Phenotypes for Anus Disease

UMLS symptoms related to Anus Disease:


nausea and vomiting, constipation, abdominal pain, diarrhea, icterus, rectal tenesmus, dyspepsia, heartburn, pruritus ani, gastrointestinal gas, anal discomfort

Drugs & Therapeutics for Anus Disease

Drugs for Anus Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 122)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
2
Ethanol Approved Phase 4 64-17-5 702
3
Lactulose Approved Phase 4 4618-18-2 11333
4 abobotulinumtoxinA Phase 4
5 Acetylcholine Release Inhibitors Phase 4
6 Neurotransmitter Agents Phase 4
7 Neuromuscular Agents Phase 4
8 Botulinum Toxins Phase 4
9 Cholinergic Agents Phase 4
10 Botulinum Toxins, Type A Phase 4
11 incobotulinumtoxinA Phase 4
12 Hemostatics Phase 4
13 Plantain Phase 4
14 Gastrointestinal Agents Phase 4
15
Acetaminophen Approved Phase 3 103-90-2 1983
16
Nifedipine Approved Phase 2, Phase 3 21829-25-4 4485
17
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
18
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
19
Tocopherol Approved, Investigational Phase 3 1406-66-2, 54-28-4 14986
20
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
21 Tocotrienol Investigational Phase 3 6829-55-6
22 Antiviral Agents Phase 3
23 valacyclovir Phase 3
24 Anti-Infective Agents Phase 3
25 Tocolytic Agents Phase 2, Phase 3
26 Anti-Bacterial Agents Phase 3
27 Alkylating Agents Phase 3
28 Albumin-Bound Paclitaxel Phase 3
29 Mitomycins Phase 3
30 Antibiotics, Antitubercular Phase 3
31 Antimitotic Agents Phase 3
32 Antimetabolites Phase 3
33 Vitamins Phase 3
34 Micronutrients Phase 3
35 Trace Elements Phase 3
36 Antioxidants Phase 3
37 Tocopherols Phase 3
38 Tocotrienols Phase 3
39 Nutrients Phase 3
40 Protective Agents Phase 3
41
Hydrocortisone acetate Approved, Vet_approved Phase 1, Phase 2 50-03-3
42
Zinc Approved, Investigational Phase 1, Phase 2 7440-66-6 32051
43
Hydrocortisone Approved, Vet_approved Phase 1, Phase 2 50-23-7 5754
44
Zinc oxide Approved Phase 1, Phase 2 1314-13-2
45
Petrolatum Approved, Investigational Phase 2 8009-03-8
46
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
47
Diltiazem Approved, Investigational Phase 2 42399-41-7 39186
48
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
49 Hydrocortisone hemisuccinate Phase 1, Phase 2
50 Hydrocortisone 17-butyrate 21-propionate Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 69)
# Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial Comparing the Efficacy of Polyethylene Glycol Alone and Polyethylene Glycol Combined With Topical Diltiazem in Treating Anal fissure in Children Unknown status NCT02419534 Phase 4 Polyethylene glycol;Polyethylene glycol with Diltiazem
2 Prospective and Randomized Trial Comparing Dopplper-Guided Transanal Hemorrhoid Artery Ligation With Recto-anal Repair (HAL-RAR) Versus Excisional Hemorrhoidectomy for the Treatment of Grade III-IV Hemorrhoids Unknown status NCT02216305 Phase 4
3 Botulin Toxin Versus Isosorbidedinitrate Ointment in Treatment Anal Fissure; A Prospective, Blinded, Randomized Trial Completed NCT00827736 Phase 4 ISDN ointment;Placebo
4 Pain and Bleeding in Subjects With Acute Anal Fissure: Comparative Evaluation of Three Treatments Completed NCT03355846 Phase 4 Centella;Proctocella;Flavonil® cps;Flavonil® Cream;Rectalgan Mousse
5 Perianal Nerval Block in Proctological Interventions: a Prospective Randomized Double Blinded Study Completed NCT03405922 Phase 4 Placebo 40 mL Saline 0.9%;40 mL Ropivacain 0.5%
6 A Comparative Efficacy and Safety Study of Lateral Subcutaneous Sphincterotomy and Botulinum Toxin Type A in the Treatment of Chronic Anal Fissure Recruiting NCT03855046 Phase 4 IncobotulinumtoxinA 50 U Intramuscular Powder for Solution
7 An Open, Randomized, Parallel Group, Single Center Study to Investigate the Effect of Lactulose Versus Plantago Ovate on the Quality of Life of Patients With Hard Stools and Hemorrhoids or Anal Fissure Terminated NCT00160290 Phase 4 Lactulose;Plantago ovata
8 A Phase 4, Multiple-dose, Pharmacokinetic, Safety, and Exploratory Efficacy Study of Nitroglycerin Ointment 0.4% (RECTIV®) in Adolescents (Age ≥12 to <17 Years) With Moderate to Severe Pain Due to Chronic Anal Fissure Withdrawn NCT01920074 Phase 4 Nitroglycerin Ointment 0.4%
9 Multi-drug Analgesia Versus Standard Solution for Perianal Block - A Prospective Study to Determine the Efficacy, Cost and Narcotic Consumption in the Post-operative Period Withdrawn NCT03105674 Phase 4 Multi-drug local anesthetics (Combination);Standard local anesthetics (Combination)
10 Treatment of Anal Fissure by Activated Human Macrophages Unknown status NCT00507364 Phase 3 Local injection of activated macrophages to anal fissure
11 Randomized Controlled Trials of Diet and Lifestyle Intervention to Promote Chinese Postpartum Women's Health Unknown status NCT01039051 Phase 2, Phase 3
12 An International, Randomized, Double-Blind, Placebo-Controlled Study of Valacyclovir for the Suppression of Recurrent Ano-Genital HSV Infections in HIV-Infected Subjects Unknown status NCT00005663 Phase 3 Valacyclovir hydrochloride
13 A Phase 3B, Randomized, Double-Blind, Placebo-Controlled, Parallel-Treatment Group, Multicenter Efficacy and Safety Study of Topical Diltiazem Hydrochloride 2% Cream in Subjects With Anal Fissure Completed NCT01690221 Phase 3 VEN 307;Placebo
14 A Randomized. Double-blind, Placebo-controlled, Multi-national Study to Determine the Effect of Cellegesic Nitroglycerin Ointment 0.4% (Cellegesic) on the Pain Associated With a Chronic Anal Fissure Completed NCT00522041 Phase 3 Cellegesic;Placebo
15 Perianal vs Endoanal Application of Glyceryl Trinitrate 0.4% Ointment in the Treatment of Chronic Anal Fissure: Results of a Randomized Controlled Trial. Completed NCT01132391 Phase 3 Rectogesic® (glyceryl trinitrate 0.4% ointment)
16 The Effect of Intra-anal Nifedipine, Used As Add-on to Conservative Therapy, on Pain in Patients With Anal Fissure Completed NCT02527109 Phase 2, Phase 3 Nifedipine
17 Perianal Application of Glyceryl Trinitrate 0.4% Ointment vs Percutaneous Posterior Tibial Nerve Stimulation in the Treatment of Chronic Anal Fissure Completed NCT02700438 Phase 3 Glyceryl trinitrate ointment
18 A Randomised,Double-Blind, Placebo-Controlled Trial of the Safety and Efficacy of Diltiazem Hydrochloride Cream in Subjects With Anal Fissure Completed NCT01217515 Phase 3 Diltiazem hydrochloride 4% cream;Diltiazem hydrochloride 2% cream
19 Patient Comfort After Stapled Hemorrhoidopexy Long Term Results of a Randomized Controlled Trial Completed NCT01533363 Phase 3
20 Randomised Phase III Trial of Chemoradiotherapy With or Without Paclitaxel in Patients With Squamous-cell Anal Cancer Enrolling by invitation NCT02526953 Phase 3 Paclitaxel;Capecitabine;Capecitabine;Mitomycins;Mitomycins
21 Application of Vitamin E Acetate Ointment vs Nitroglycerin Ointment for the Treatment of Chronic Anal Fissure Not yet recruiting NCT03787030 Phase 3 Vitamin E Acetate ointment;Glyceryl trinitrate ointment
22 Double Blind Randomized Placebo-control Trial of Allium Ampeloprasum Spp.Iranicum Cream Effect for the Management of Hemorrhoids Symptoms Unknown status NCT02301052 Phase 1, Phase 2 Leek topical cream;placebo topical cream;Anti-hemorrhoid topical cream
23 Single Blind, Randomized Controlled, Multicenter Study to Evaluate the Efficacy and Convenience of Electronic Bidet With Very Low Force Flow Fountain System for Pain Control and Wound Healing After Operation for Anal Disease, Compared to Conventional Sitz Bath Unknown status NCT02353156 Phase 2
24 A Phase II, Multicentre, Open, Randomised, Parallel Group, Dose Ranging Study to Define the Efficacy of Dysport® in the Treatment of Anal Fissure. Completed NCT00210444 Phase 2
25 An Open Label Study to Examine the Effect of Coated Nifedipine Suppository on Anal Fissure Pain and Healing in Human Subjects Completed NCT00972907 Phase 1, Phase 2 Nifedipine coated suppositories
26 Assessing and Comparing the Effect of Diltiazem Gel Versus Nitroglycerin Ointment in Healing Process of Scleroderma Digital Ulcers. Completed NCT02801305 Phase 2 Diltiazem Gel 2%;Nitroglycerin Ointment 2%;Vaseline
27 Feasibility Study of Safety, Toxicity, and Compliance of Concomitant Chemoradiotherapy for HIV-Associated Locally-Advanced Cervical Cancer Completed NCT01590017 Phase 2 cisplatin
28 AMC-072: Protective Effect of Quadrivalent Vaccine in Young HIV-Positive Males Who Have Sex With Males Completed NCT01209325 Phase 2
29 Comparative Evaluation of MEBO Ointment and Topical Diltiazem Ointment in the Treatment of Acute Anal Fissure: a Randomized Clinical Trial Not yet recruiting NCT04153032 Phase 2 Diltiazem;Mebo
30 An Open Label Multi-Dose Study to Examine the Effect of Coated Nifedipine Suppository on Anal Fissure Pain and Healing Terminated NCT02023047 Phase 1, Phase 2 Nifedipine 12 mg coated suppositories
31 An Open-Label, Single- and Multi-Dose Pharmacokinetic (PK) Study of Oral Diltiazem and Topical Diltiazem Hydrochloride Unknown status NCT01816191 Phase 1 Diltiazem Hydrochloride Cream and Oral Diltiazem
32 Prevention and/or Reduction of Hemorrhoids and/or Thrombosed External Hemorrhoids (TEH) Using the HEM-AVERT Perianal Stabilizer Instrument Completed NCT00487045 Phase 1
33 A Single Centre, Open-label, Randomised, Single Dose, Six Period, Reference Replicate, Crossover Study to Evaluate the Bioavailability of MED2005 Completed NCT04008732 Phase 1 MED2005;Nitrostat 0.6Mg Sublingual Tablet;Nitro Pohl
34 A Multicenter, Randomized Controlled Trial of 9-valent HPV Vaccination in Preventing Recurrence of High-grade Anal Dysplasia in HIV-positive MSM Not yet recruiting NCT03947775 Phase 1 9-valent HPV vaccination
35 Pharmacokinetics, Pharmacodynamics and Safety Comparative Trial of Isosorbide Mononitrate Gel in Participants With Anal Fissure and Healthy Volunteers. Withdrawn NCT02667535 Phase 1 Isosorbide Mononitrate
36 Ultrasound Guided Lateral Sphincterotomy: Long Term Results Unknown status NCT02020915
37 Incision Type for Lateral Internal Sphincterotomy Unknown status NCT00980369
38 Treatment Of Chronic Anal Fissure (TOCA): a Randomized Clinical Trial on Levorag® Emulgel Versus Diltiazem Gel 2% Unknown status NCT02158013 Diltiazem
39 Randomized Controlled Trial on Practicability of Coloshield in Transanal and Anal Surgery Unknown status NCT02579330
40 Measurement of Stress During Anesthesia With "Pain Detector" on Patients Receiving Atropine Unknown status NCT00328900 Administration of 0,7 mg of atropine
41 Comparison of Biofeedback Therapy and Botulinum Toxin Type A Injections for Treatment of Painful Levator Ani Syndrome in Women: A Randomized, Prospective Trial Unknown status NCT00564707
42 Cohort Study of Chronic Anal Fissure Management Using CO2 Laser Completed NCT03872765
43 Posterolateral Versus Lateral Internal Anal Sphincterotomy for Chronic Anal Fissure: A Randomized Clinical Trial Completed NCT03426449
44 Randomized Clinical Trial of Transcutaneous Electrical Posterior Tibial Nerve Stimulation Versus Lateral Internal Sphincterotomy for Treatment of Chronic Anal Fissure. Completed NCT02395809
45 Treatment of Chronic Anal Fissure, Lateral Internal Sphincterotomy Versus Local Injection of High Dose Botulinum Toxin: A Randomized Clinical Trial Completed NCT04166175
46 Ultrasound Guided Analgesic Caudal Block in Anal Canal Surgery Completed NCT03345511
47 Topical 5% Minoxidil Versus 0.2%Topical Glyceryl Trinitrate in Treatment of Chronic Anal Fissure: a Randomized Controlled Trial Completed NCT03528772 Minoxidil;Glyceryl trinitrate
48 Percutaneous Tibial Nerve Stimulation - PTNS: an Alternative Treatment Option for Chronic Therapy Resistant Anal Fissure Completed NCT03554421
49 A Novel Method for Chronic Anal Fissure Treatment: Adipose Derived Regenerative Cells - A Pilot Study Completed NCT02628522
50 Comparative Study of Conventional Lateral Internal Sphincterotomy, V-Y Anoplasty and Tailored Lateral Internal Sphincterotomy With V-Y Anoplasty in Treatment of Chronic Anal Fissure Completed NCT01500889

Search NIH Clinical Center for Anus Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Benzocaine
BENZOCAINE PWDR
Botulinum Toxin Type A
Nitroglycerin
Phenylephrine
Phenylephrine bitartrate
Phenylephrine Hydrochloride
Phenylephrine Tannate
pramoxine
Pramoxine hydrochloride

Cochrane evidence based reviews: anus diseases

Genetic Tests for Anus Disease

Anatomical Context for Anus Disease

MalaCards organs/tissues related to Anus Disease:

40
Bone, Kidney, T Cells, Skin, Cervix, Myeloid, B Cells

Publications for Anus Disease

Articles related to Anus Disease:

# Title Authors PMID Year
1
A Practical Guide to Biofeedback Therapy for Pelvic Floor Disorders. 42
31016468 2019
2
Management of anoperineal lesions in Crohn's disease: a French National Society of Coloproctology national consensus. 42
30604249 2018
3
The clinical and therapeutic approach to anal stenosis. 42
30588920 2018
4
[Acupoints heat-sensitive moxibustion in the application of traditional Chinese surgery]. 61
26946757 2016
5
[Chronic anal fissure--conservative or surgical treatment?]. 61
15181755 2004
6
[Contribution of endo-anal sonography in non-tumoral anus diseases]. 61
11275617 2001
7
[Treatment of anus diseases with a corticoid-free drug combination]. 61
560091 1977
8
[Differential diagnosis of rectal hemorrhage and painful anus diseases]. 61
4541576 1973
9
[Open symposium; postoperative complications and sequela of anus diseases]. 61
5311735 1970

Variations for Anus Disease

ClinVar genetic disease variations for Anus Disease:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 FREM2 NM_207361.6(FREM2):c.6727C>T (p.Arg2243Ter)SNV Pathogenic 523570 rs767978562 13:39425230-39425230 13:38851093-38851093

Expression for Anus Disease

Search GEO for disease gene expression data for Anus Disease.

Pathways for Anus Disease

Pathways related to Anus Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.67 TP53 TLR8 TLR7 TLR4
2 11.47 TLR8 TLR7 TLR4
3 11.4 CD8A CD4 CCR6
4
Show member pathways
11.37 TLR8 TLR7 TLR4 CD4
5 11.3 TLR7 CD8A CD4
6
Show member pathways
11.02 TP53 TLR8 TLR7 TLR4

GO Terms for Anus Disease

Cellular components related to Anus Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.02 TLR8 TLR4 CD8A CD4 CCR6

Biological processes related to Anus Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cellular response to mechanical stimulus GO:0071260 9.63 TLR8 TLR7 TLR4
2 immune response GO:0006955 9.63 TLR8 TLR7 TLR4 CD8A CD4 CCR6
3 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.61 TLR8 TLR7 TLR4
4 positive regulation of interleukin-6 production GO:0032755 9.58 TLR8 TLR7 TLR4
5 toll-like receptor signaling pathway GO:0002224 9.54 TLR8 TLR7 TLR4
6 replicative senescence GO:0090399 9.51 TP53 CDKN2A
7 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.49 TLR8 TLR7
8 I-kappaB phosphorylation GO:0007252 9.48 TLR7 TLR4
9 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.43 TLR8 TLR7 TLR4
10 positive regulation of interferon-alpha biosynthetic process GO:0045356 9.32 TLR8 TLR7
11 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.13 TLR8 TLR7 TLR4
12 positive regulation of interferon-beta biosynthetic process GO:0045359 8.8 TLR8 TLR7 TLR4

Molecular functions related to Anus Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.26 TLR8 TLR4 CD4 CCR6
2 signaling pattern recognition receptor activity GO:0008329 9.16 TLR8 TLR7
3 transmembrane signaling receptor activity GO:0004888 9.02 TLR8 TLR7 TLR4 GPR182 CD4

Sources for Anus Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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