Aliases & Classifications for Anus Disease

MalaCards integrated aliases for Anus Disease:

Name: Anus Disease 12 15
Anus Diseases 44 73
Anal Fissure 12 73
Nontraumatic Tear of Anus 12
Anal Fissure and Fistula 12
Abnormality of the Anus 6
Solitary Anal Ulcer 12
Fissure in Ano 12
Anal Disorders 43
Ulcer of Anus 12
Anal Disease 12
Anal Ulcer 12


External Ids:

Disease Ontology 12 DOID:3128
MeSH 44 D001004
NCIt 50 C26695
SNOMED-CT 68 32110003
ICD10 33 K60.2

Summaries for Anus Disease

MedlinePlus : 43 The anus is the opening of the rectum through which stool passes out of your body. Problems with the anus are common. They include hemorrhoids, abscesses, fissures (cracks), and cancer. You may be embarrassed to talk about your anal troubles. But it is important to let your doctor know, especially if you have pain or bleeding. The more details you can give about your problem, the better your doctor will be able to help you. Treatments vary depending on the particular problem. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Anus Disease, also known as anus diseases, is related to rectal disease and ulcer of anus and rectum, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Anus Disease is FREM2 (FRAS1 Related Extracellular Matrix Protein 2). The drugs Diltiazem and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and bone.

Wikipedia : 76 The anus (from Latin anus meaning \"ring\", \"circle\") is an opening at the opposite end of an... more...

Related Diseases for Anus Disease

Diseases related to Anus Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 rectal disease 28.6 CLP1 KATNB1
2 ulcer of anus and rectum 12.2
3 constipation 11.3
4 crohn's disease 10.9
5 anal fistula 10.7
6 hypertonia 10.1
7 solitary rectal ulcer syndrome 10.1
8 histoplasmosis 9.7

Comorbidity relations with Anus Disease via Phenotypic Disease Network (PDN):

Active Peptic Ulcer Disease

Graphical network of the top 20 diseases related to Anus Disease:

Diseases related to Anus Disease

Symptoms & Phenotypes for Anus Disease

UMLS symptoms related to Anus Disease:

abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, pruritus ani, gastrointestinal gas, anal discomfort, rectal tenesmus

Drugs & Therapeutics for Anus Disease

Drugs for Anus Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 185)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Diltiazem Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 42399-41-7 39186
Acetylcholine Approved Phase 4,Phase 2,Not Applicable 51-84-3 187
Nitric Oxide Approved Phase 4,Phase 1 10102-43-9 145068 160954
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
Nitroglycerin Approved, Investigational Phase 4,Phase 3 55-63-0 4510
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
Lactulose Approved Phase 4 4618-18-2 11333
12 Antihypertensive Agents Phase 4,Phase 3,Phase 1,Not Applicable
13 calcium channel blockers Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
14 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15 Cathartics Phase 4
16 Laxatives Phase 4
17 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 abobotulinumtoxinA Phase 4,Phase 2,Not Applicable
19 Botulinum Toxins Phase 4,Phase 2,Not Applicable
20 Botulinum Toxins, Type A Phase 4,Phase 2,Not Applicable
21 Cholinergic Agents Phase 4,Phase 2,Not Applicable
22 Neuromuscular Agents Phase 4,Phase 2,Not Applicable
23 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
24 onabotulinumtoxinA Phase 4,Phase 2,Not Applicable
25 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
26 Anesthetics Phase 4,Phase 3,Not Applicable
27 Anti-Arrhythmia Agents Phase 4,Not Applicable
28 Pharmaceutical Solutions Phase 4,Not Applicable
29 Nitric Oxide Donors Phase 4,Phase 1
30 Analgesics Phase 4,Phase 2,Not Applicable
31 Analgesics, Non-Narcotic Phase 4,Phase 2,Not Applicable
32 Anesthetics, Local Phase 4,Not Applicable
33 Anti-Inflammatory Agents Phase 4,Not Applicable
34 Anti-Inflammatory Agents, Non-Steroidal Phase 4
35 Antirheumatic Agents Phase 4,Phase 1,Phase 2
36 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
37 Cyclooxygenase Inhibitors Phase 4
38 Diuretics, Potassium Sparing Phase 4,Not Applicable
39 Sodium Channel Blockers Phase 4,Not Applicable
40 Gastrointestinal Agents Phase 4,Phase 3,Not Applicable
41 Epinephryl borate Phase 4,Not Applicable
42 Narcotics Phase 4,Not Applicable
43 Plantain Nutraceutical Phase 4
Acyclovir Approved Phase 3,Not Applicable 59277-89-3 2022
Cisplatin Approved Phase 3,Phase 2 15663-27-1 84093 441203 2767
Fluorouracil Approved Phase 3,Phase 2,Phase 1 51-21-8 3385
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
Acetaminophen Approved Phase 3,Not Applicable 103-90-2 1983
Octreotide Approved, Investigational Phase 3 83150-76-9 383414 6400441
Nifedipine Approved Phase 2, Phase 3,Phase 1 21829-25-4 4485

Interventional clinical trials:

(show top 50) (show all 175)
# Name Status NCT ID Phase Drugs
1 Pediatrics Anal Fissures Treatment With Polyethylene Glycol Unknown status NCT02419534 Phase 4 Polyethylene glycol;Polyethylene glycol with Diltiazem
2 Comparison of Treatment Success of Botox Injection in the Internal Sphincter Versus Isosorbidedinitrate Ointment in Patients With an Anal Fissure Completed NCT00827736 Phase 4 ISDN ointment;Placebo
3 Efficacy and Safety of CLIFE1 Gel in Benign Anorectal Surgery Completed NCT02961855 Phase 4 anesthesics plus antiinflammatory, CLIFE1;local anesthesics, CLIFE2
4 Pain and Bleeding in Subjects With Acute Anal Fissure: Comparative Evaluation of Three Treatments Recruiting NCT03355846 Phase 4 Centella;Proctocella;Flavonil® cps;Flavonil® Cream;Rectalgan Mousse
5 Perianal Nerval Block in Proctological Interventions Recruiting NCT03405922 Phase 4 Placebo 40 mL Saline 0.9%;40 mL Ropivacain 0.5%
6 Trial to Evaluate Effect of Lactulose on Hard Stools in Patients With Hemorrhoids or Anal Fissures Terminated NCT00160290 Phase 4 Lactulose;Plantago ovata
7 Pharmacokinetic,Safety and Exploratory Efficacy of RECTIV® in Adolescents With Chronic Anal Fissure Withdrawn NCT01920074 Phase 4 Nitroglycerin Ointment 0.4%
8 Multi-Drug Analgesia vs. Standard Solution for Anal Surgery Withdrawn NCT03105674 Phase 4 Multi-drug local anesthetics (Combination);Standard local anesthetics (Combination)
9 A Study of Valacyclovir as Treatment for Genital Herpes Simplex Virus in HIV-Infected Patients Unknown status NCT00005663 Phase 3 Valacyclovir hydrochloride
10 Treatment of Anal Fissure by Activated Human Macrophages Unknown status NCT00507364 Phase 3 Local injection of activated macrophages to anal fissure
11 Diet and Lifestyle Intervention Study in Postpartum Women in China Unknown status NCT01039051 Phase 2, Phase 3
12 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Unknown status NCT00003652 Phase 3 cisplatin;fluorouracil
13 Glyceryl Trinitrate Ointment vs Posterior Tibial Nerve Stimulation in the Treatment of Anal Fissure Completed NCT02700438 Phase 3 Glyceryl trinitrate ointment
14 Efficacy and Safety Study With Diltiazem Hydrochloride Cream to Treat Anal Fissures Completed NCT01690221 Phase 3 VEN 307;Placebo
15 Diltiazem Hydrochloride Cream for Anal Fissure Completed NCT01217515 Phase 3 Diltiazem hydrochloride 4% cream;Diltiazem hydrochloride 2% cream
16 Perianal Versus Endoanal Application of Glyceryl Trinitrate 0.4% Ointment for Chronic Anal Fissure Completed NCT01132391 Phase 3 Rectogesic® (glyceryl trinitrate 0.4% ointment)
17 A Study to Determine the Effect of Nitroglycerin Ointment 0.4% (Cellegesic) on the Pain Associated With Chronic Anal Fissures Completed NCT00522041 Phase 3 Cellegesic;Placebo
18 Multivalent HPV (Human Papillomavirus) Vaccine Study in 16- to 26-Year Old Men and Women (V503-003) Completed NCT01651949 Phase 3
19 Infrared Coagulator Ablation or Observation in Preventing Anal Cancer in HIV-Positive Patients With Anal Neoplasia Completed NCT01164722 Phase 3
20 Octreotide in Preventing or Reducing Diarrhea in Patients Receiving Chemoradiotherapy for Anal or Rectal Cancer Completed NCT00075868 Phase 3 octreotide acetate
21 Radiation Therapy Plus Fluorouracil With or Without Additional Chemotherapy in Treating Patients With Primary Anal Cancer Completed NCT00025090 Phase 3 cisplatin;fluorouracil;mitomycin C
22 Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Completed NCT00003596 Phase 3 cisplatin;fluorouracil;mitomycin C
23 Effects of Deep Regional Hyperthermia in Patients With Anal Carcinoma Treated by Standard Radiochemotherapy Recruiting NCT02369939 Phase 3 Mitomycin C;5-Fluorouracil
24 Topical or Ablative Treatment in Preventing Anal Cancer in Patients With HIV and Anal High-Grade Squamous Intraepithelial Lesions Recruiting NCT02135419 Phase 3 imiquimod;fluorouracil
25 The Effect of Intra-anal Nifedipine, Used As Add-on to Conservative Therapy, on Pain in Patients With Anal Fissure Active, not recruiting NCT02527109 Phase 2, Phase 3 Nifedipine
26 Efficacy Study of Chemoradiotherapy With or Without Paclitaxel in Squamous-cell Anal Carcinoma Patients Enrolling by invitation NCT02526953 Phase 3 Paclitaxel;Capecitabine;Capecitabine;Mitomycins;Mitomycins
27 Radiation Therapy, Mitomycin, and Either Fluorouracil or Cisplatin in Treating Patients With Locally Advanced Anal Cancer Terminated NCT00068744 Phase 2, Phase 3 cisplatin;fluorouracil;mitomycin C
28 International Multicentre Study in Advanced Anal Cancer Comparing Cisplatin Plus 5 FU vs Carboplatin Plus Weekly Paclitaxel Unknown status NCT02051868 Phase 2 Cisplatin;5-Fluorouracil (5-FU);Carboplatin;Paclitaxel
29 Radiation Therapy, Cisplatin, Fluorouracil, and Cetuximab in Treating Patients With Locally Advanced Anal Cancer Unknown status NCT00955240 Phase 2 cisplatin;fluorouracil
30 An Open Label Study to Examine the Effect of Coated Nifedipine Suppository on Anal Fissure Pain and Healing in Human Subjects Completed NCT00972907 Phase 1, Phase 2 Nifedipine coated suppositories
31 Efficacy Study of Dysport® in the Treatment of Anal Fissure. Completed NCT00210444 Phase 2 Botulinum toxin type A (Dysport)
32 T Cell Receptor Immunotherapy Targeting HPV-16 E6 for HPV-Associated Cancers Completed NCT02280811 Phase 1, Phase 2 Fludarabine;Cyclophosphamide;Aldesleukin
33 A Study of Substitution of 5-FU (Fluorouracil) by Capecitabine in Scheme of Chemo-radiotherapy in Patients With Squamous Cell Carcinoma of the Anal Canal. Completed NCT01941966 Phase 2 Capecitabine;Mitomycins
34 Oral Rigosertib for Squamous Cell Carcinoma Completed NCT01807546 Phase 2 rigosertib
35 [F-18] Fluorothymidine PET/CT Imaging for Pelvic Cancers Completed NCT01717391 Phase 2 fluorothymidine F 18
36 Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Human Papillomavirus-Associated Cancers Completed NCT01585428 Phase 2 Fludarabine;Cyclophosphamide;Aldesleukin
37 Vectibix for the Treatment of Anal Cancer Completed NCT01285778 Phase 2 panitumumab, mytomicin C, 5-FU, radiation
38 Vaccine Therapy in Preventing Human Papillomavirus Infection in Young HIV-Positive Male Patients Who Have Sex With Males Completed NCT01209325 Phase 2
39 Treatment of Anal High-grade Squamous Intraepithelial Lesions (HSIL) Through Use of a Chinese Herbal Topical Cream Completed NCT00622440 Phase 2 AIJP (Arnebia Indigo Jade Pearl);Placebo
40 Cidofovir in Treating HIV-Infected Patients With High-Grade Squamous Intraepithelial Lesions of the Skin Near the Anus Completed NCT00550589 Phase 2 cidofovir
41 Tolerability, Safety, & Efficacy of Argon Plasma Coagulation to Treat Anal Intraepithelial Neoplasia in HIV-Positive Men Completed NCT00428285 Phase 2
42 Intensity-Modulated Radiation Therapy, Fluorouracil, and Mitomycin C in Treating Patients With Invasive Anal Cancer Completed NCT00423293 Phase 2 fluorouracil;mitomycin C
43 Combined Modality Therapy for Patients With With HIV and Stage I, Stage II, or Stage III Anal Cancer Completed NCT00324415 Phase 2 cisplatin;fluorouracil
44 Capecitabine, Oxaliplatin, and Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Completed NCT00093379 Phase 2 Capecitabine;Oxaliplatin
45 SGN-00101 in Preventing Anal Cancer in Patients With HIV Who Have Anal Neoplasia Completed NCT00052897 Phase 1, Phase 2
46 A Study of mDCF in Combination or Not With Atezolizumab in Advanced Squamous Cell Anal Carcinoma Recruiting NCT03519295 Phase 2 MPDL3280A;mDCF
47 VGX-3100 Delivered Intramuscularly (IM) Followed by Electroporation (EP) for the Treatment of HPV-16 and/or HPV-18 Related Anal or Anal/Peri-Anal, High Grade Squamous Intraepithelial Lesion (HSIL) in Individuals Seronegative for Human Immunodeficiency Vir Recruiting NCT03499795 Phase 2
48 M7824 in Subjects With HPV Associated Malignancies Recruiting NCT03427411 Phase 2 M7824
49 Study of IMRT Radiotherapy Concurrent Chemothrerapy for Anal Cancer Recruiting NCT03381352 Phase 2 Capecitabine;Mitomycin C
50 Avelumab With Valproic Acid in Virus-associated Cancer Recruiting NCT03357757 Phase 2 Valproic Acid

Search NIH Clinical Center for Anus Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cochrane evidence based reviews: anus diseases

Genetic Tests for Anus Disease

Anatomical Context for Anus Disease

MalaCards organs/tissues related to Anus Disease:

Kidney, Testes, Bone, Lung, Breast, Liver, T Cells

Publications for Anus Disease

Articles related to Anus Disease:

(show all 17)
# Title Authors Year
Combined treatment approach to chronic anal fissure with associated anal fistula. ( 29205737 )
Local and Oral Antibiotics with Avoidance of Constipation (LOABAC) Treatment for Anal Fissure: a New Concept in Conservative Management. ( 27186052 )
Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa. ( 28491983 )
Quality of patient information on the internet for the treatment of anal fistula and anal fissure. ( 25294731 )
Botulinum toxin for chronic anal fissure after biliopancreatic diversion for morbid obesity. ( 22416176 )
Delayed fecal incontinence following surgery for anal fissure. ( 21805112 )
Early results of fissurectomy and advancement flap for resistant chronic anal fissure without hypertonia of the internal anal sphincter. ( 20336902 )
Fissurectomy and anal advancement flap for anterior chronic anal fissure without hypertonia of the internal anal sphincter in females. ( 19843117 )
Fissurectomy combined with anoplasty and injection of botulinum toxin in treatment of anterior chronic anal fissure with hypertonia of internal anal sphincter: a pilot study. ( 20127381 )
Haemorrhoids, rectal prolapse, anal fissure, peri-anal fistulae and sexually transmitted diseases. ( 19647691 )
Case report: herpes meningitis complicating genital herpes presenting as anal fissure. ( 17939904 )
A study of fecal incontinence in patients with chronic anal fissure: prospective, randomized, controlled trial of the extent of internal anal sphincter division during lateral sphincterotomy. ( 17665247 )
Anal fissure, rectal bleeding and proctitis as complications of systemic isotretinoin therapy: report of two cases. ( 17062102 )
Nitric oxide deficiency in the internal anal sphincter of patients with chronic anal fissure. ( 16052310 )
By the way, doctor. I had pain some bleeding with bowel movements. I thought it was a hemorrhoid, but my doctor says it's an anal fissure. How did I get this, and what's the best way to treat it? ( 15381475 )
Anorectal pain and irritation: anal fissure, levator syndrome, proctalgia fugax, and pruritus ani. ( 9922294 )
Sustained internal sphincter hypertonia in patients with chronic anal fissure. ( 8181401 )

Variations for Anus Disease

ClinVar genetic disease variations for Anus Disease:

# Gene Variation Type Significance SNP ID Assembly Location
1 FREM2 NM_207361.5(FREM2): c.6727C> T (p.Arg2243Ter) single nucleotide variant Pathogenic rs767978562 GRCh37 Chromosome 13, 39425230: 39425230
2 FREM2 NM_207361.5(FREM2): c.6727C> T (p.Arg2243Ter) single nucleotide variant Pathogenic rs767978562 GRCh38 Chromosome 13, 38851093: 38851093

Expression for Anus Disease

Search GEO for disease gene expression data for Anus Disease.

Pathways for Anus Disease

GO Terms for Anus Disease

Sources for Anus Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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