MCID: ART016
MIFTS: 70

Aortic Aneurysm

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Aortic Aneurysm

MalaCards integrated aliases for Aortic Aneurysm:

Name: Aortic Aneurysm 12 76 29 6 43 3 44 15 73
Thoracoabdominal Aortic Aneurysm, Ruptured 12 73
Ruptured Abdominal Aortic Aneurysm 12 73
Ruptured Thoracic Aortic Aneurysm 12 73
Aortic Rupture 44 73
Aortic Aneurysm Without Mention of Rupture Nos 73
Thoracic Aortic Aneurysm Which Has Ruptured 12
Ruptured Thoracoabdominal Aortic Aneurysm 12
Abdominal Aortic Aneurysm, Ruptured 12
Thoracic Aortic Aneurysm, Ruptured 12
Ruptured Thoracic Aneurysm 12
Aortic Aneurysm, Ruptured 73
Ruptured Aortic Aneurysm 12

Classifications:



Summaries for Aortic Aneurysm

MedlinePlus : 43 An aneurysm is a bulge or "ballooning" in the wall of an artery. Arteries are blood vessels that carry oxygen-rich blood from the heart to other parts of the body. If an aneurysm grows large, it can burst and cause dangerous bleeding or even death. Most aneurysms are in the aorta, the main artery that runs from the heart through the chest and abdomen. There are two types of aortic aneurysm: Thoracic aortic aneurysms (TAA) - these occur in the part of the aorta running through the chest Abdominal aortic aneurysms (AAA) - these occur in the part of the aorta running through the abdomen Most aneurysms are found during tests done for other reasons. Some people are at high risk for aneurysms. It is important for them to get screening, because aneurysms can develop and become large before causing any symptoms. Screening is recommended for people between the ages of 65 and 75 if they have a family history, or if they are men who have smoked. Doctors use imaging tests to find aneurysms. Medicines and surgery are the two main treatments. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Aortic Aneurysm, also known as thoracoabdominal aortic aneurysm, ruptured, is related to aortic aneurysm, familial abdominal, 1 and familial thoracic aortic aneurysm and dissection, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Aortic Aneurysm is FBN1 (Fibrillin 1), and among its related pathways/superpathways are ERK Signaling and PAK Pathway. The drugs Atenolol and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size.

CDC : 3 An aortic aneurysm is a balloon-like bulge in the aorta, the large artery that carries blood from the heart through the chest and torso.

Wikipedia : 76 An aortic aneurysm is an enlargement (dilation) of the aorta to greater than 1.5 times normal size. They... more...

Related Diseases for Aortic Aneurysm

Diseases related to Aortic Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 403)
# Related Disease Score Top Affiliating Genes
1 aortic aneurysm, familial abdominal, 1 34.4 CDKN2B-AS1 ELN FBN1
2 familial thoracic aortic aneurysm and dissection 34.2 COL3A1 FBN1 SMAD3 TGFBR1 TGFBR2
3 aortic aneurysm, familial thoracic 6 34.2 ACTA2 MYH11 MYLK
4 familial abdominal aortic aneurysm 33.8 COL3A1 ELN FBN1 MYLK
5 aortic aneurysm, familial thoracic 2 33.6 ACTA2 FBN1 SLC2A10
6 loeys-dietz syndrome 1 33.3 COL3A1 FBN1 MYH11 SMAD3 TGFB2 TGFBR1
7 loeys-dietz syndrome 2 33.2 MYH11 TGFBR2
8 aortic aneurysm, familial thoracic 1 33.1 ACTA2 COL3A1 EFEMP2 ELN FBN1 HIF1A-AS1
9 loeys-dietz syndrome 32.8 ACTA2 COL3A1 FBN1 FBN2 MYH11 MYLK
10 marfan syndrome 32.1 ACTA2 COL3A1 ELN FBN1 FBN2 TGFBR1
11 loeys-dietz syndrome 4 31.9 SMAD3 TGFB2 TGFBR1 TGFBR2
12 autosomal recessive cutis laxa type i 31.9 EFEMP2 ELN LOX TGFBR1 TGFBR2
13 cutis laxa, autosomal recessive, type ib 31.9 EFEMP2 ELN LOX
14 loeys-dietz syndrome 3 31.2 ACTA2 COL3A1 FBN1 LOX MYH11 MYLK
15 aortic valve disease 1 30.7 ACTA2 ELN FBN1 FBN2 NOTCH1 TGFBR2
16 aortic valve insufficiency 30.6 ELN FBN1 NOTCH1
17 exfoliation syndrome 30.0 ELN FBN1 LOX
18 arterial tortuosity syndrome 29.8 EFEMP2 ELN SLC2A10 TGFBR1
19 orthostatic intolerance 29.7 ELN FBN1 FBN2
20 connective tissue disease 29.7 ACTA2 COL3A1 ELN FBN1 FBN2
21 intracranial aneurysm 29.7 CDKN2B-AS1 COL3A1 ELN FBN2 LOX
22 cerebral arterial disease 29.5 ACTA2 CDKN2B-AS1 ELN
23 aortic disease 29.4 ACTA2 EFEMP2 ELN FBN1 MYH11 NOTCH1
24 aortic aneurysm, familial thoracic 4 12.7
25 aortic aneurysm, familial thoracic 10 12.5
26 aortic aneurysm, familial thoracic 7 12.5
27 aortic aneurysm, familial thoracic 9 12.5
28 aortic aneurysm, familial thoracic 11 12.5
29 aortic aneurysm, familial thoracic 8 12.5
30 aortic aneurysm, familial abdominal, 2 12.3
31 aortic aneurysm, familial abdominal, 4 12.2
32 aortic aneurysm, familial abdominal, 3 12.2
33 temporal arteritis 11.5
34 multisystemic smooth muscle dysfunction syndrome 11.4
35 cutis laxa, autosomal dominant 1 11.3
36 meester-loeys syndrome 11.3
37 phace association 11.2
38 cutis laxa, autosomal dominant 2 11.1
39 loeys-dietz syndrome 5 11.1
40 cutis laxa, autosomal dominant 3 11.1
41 cystic medial necrosis of aorta 11.1
42 horseshoe kidney 10.6
43 ischemia 10.6
44 aortic coarctation 10.5
45 aortitis 10.4
46 duodenal obstruction 10.4
47 paraplegia 10.4
48 vascular disease 10.4
49 arteries, anomalies of 10.3
50 peripheral vascular disease 10.3

Comorbidity relations with Aortic Aneurysm via Phenotypic Disease Network (PDN): (show all 15)


Acute Cystitis Acute Kidney Failure
Acute Vascular Insufficiency of Intestine Aortic Valve Disease 1
Cardiac Arrest Chronic Myocardial Ischemia
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Paralytic Ileus Peripheral Vascular Disease
Respiratory Failure

Graphical network of the top 20 diseases related to Aortic Aneurysm:



Diseases related to Aortic Aneurysm

Symptoms & Phenotypes for Aortic Aneurysm

UMLS symptoms related to Aortic Aneurysm:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

26 (show all 28)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 10.07 TGFBR2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 10.07 TGFB2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 10.07 TGFB2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 10.07 PRKG1 TGFBR2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 10.07 TGFBR2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 10.07 TGFBR1 TGFBR2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 10.07 TGFBR1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 10.07 TGFBR2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 10.07 TGFBR1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 10.07 PRKG1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 10.07 TGFBR1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 10.07 TGFB2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 10.07 TGFBR2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 10.07 TGFB2
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 10.07 PRKG1 TGFB2 TGFBR1 TGFBR2
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 10.07 TGFBR2
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 10.07 TGFB2
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 10.07 TGFB2
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 10.07 PRKG1
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 10.07 TGFBR1
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 10.07 TGFBR2
22 Decreased viability GR00107-A-1 9.92 TGFBR2
23 Decreased viability GR00221-A-1 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
24 Decreased viability GR00221-A-2 9.92 COL3A1 PRKG1
25 Decreased viability GR00221-A-3 9.92 TGFBR2
26 Decreased viability GR00221-A-4 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
27 Decreased viability GR00301-A 9.92 PRKG1
28 Decreased viability GR00402-S-2 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2

MGI Mouse Phenotypes related to Aortic Aneurysm:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.43 ACTA2 COL3A1 EFEMP2 FBN1 FBN2 LOX
2 cellular MP:0005384 10.29 BGN COL3A1 EFEMP2 FBN1 FBN2 MYH11
3 homeostasis/metabolism MP:0005376 10.25 BGN COL3A1 FBN1 FBN2 LOX MYH11
4 growth/size/body region MP:0005378 10.2 BGN COL3A1 FBN1 FBN2 MYH11 MYLK
5 immune system MP:0005387 10.18 BGN COL3A1 FBN1 MFAP5 MYLK NOTCH1
6 mortality/aging MP:0010768 10.17 BGN COL3A1 EFEMP2 FBN1 FBN2 LOX
7 digestive/alimentary MP:0005381 10.13 COL3A1 MYH11 MYLK NOTCH1 PRKG1 SMAD3
8 muscle MP:0005369 10.1 ACTA2 BGN COL3A1 EFEMP2 FBN1 FBN2
9 craniofacial MP:0005382 10.04 BGN FBN1 FBN2 NOTCH1 SMAD3 TGFB2
10 integument MP:0010771 10.02 BGN COL3A1 EFEMP2 FBN1 LOX MYH11
11 renal/urinary system MP:0005367 9.76 FBN1 MYH11 MYLK NOTCH1 PRKG1 SLC2A10
12 respiratory system MP:0005388 9.7 COL3A1 EFEMP2 FBN1 FBN2 LOX MYH11
13 skeleton MP:0005390 9.36 BGN EFEMP2 FBN1 FBN2 MFAP5 MYLK

Drugs & Therapeutics for Aortic Aneurysm

Drugs for Aortic Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 277)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Atenolol Approved Phase 4 29122-68-7 2249
2
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
3
Angiotensin II Approved, Investigational Phase 4,Phase 3,Not Applicable 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
4
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
5
Bupivacaine Approved, Investigational Phase 4,Phase 2,Not Applicable 2180-92-9, 38396-39-3 2474
6
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
7
Morphine Approved, Investigational Phase 4,Phase 3 57-27-2 5288826
8
Ropivacaine Approved Phase 4,Phase 3 84057-95-4 175805 71273
9
Amlodipine Approved Phase 4,Phase 3,Phase 2,Not Applicable 88150-42-9 2162
10
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
11
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
12
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
13
Remifentanil Approved Phase 4,Phase 2 132875-61-7 60815
14
Methylprednisolone hemisuccinate Approved Phase 4,Not Applicable 2921-57-5
15
Methylprednisolone Approved, Vet_approved Phase 4,Not Applicable 83-43-2 6741
16
Prednisolone phosphate Approved, Vet_approved Phase 4,Not Applicable 302-25-0
17
Prednisolone Approved, Vet_approved Phase 4,Not Applicable 50-24-8 5755
18
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
19
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
20
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
21
Iodine Approved, Investigational Phase 4,Not Applicable 7553-56-2 807
22
Olmesartan Approved, Investigational Phase 4 144689-63-4, 144689-24-7 158781 130881
23
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
24
Eplerenone Approved Phase 4 107724-20-9 443872 150310
25
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
26
Tranexamic Acid Approved Phase 4,Phase 3 1197-18-8 5526
27
Clevidipine Approved, Investigational Phase 4,Not Applicable 167221-71-8
28
Histidine Approved, Nutraceutical Phase 4 71-00-1 6274
29
Prednisolone hemisuccinate Experimental Phase 4,Not Applicable 2920-86-7
30 Sympatholytics Phase 4,Early Phase 1
31 Angiotensin Receptor Antagonists Phase 4,Phase 3,Not Applicable
32 Adrenergic Antagonists Phase 4,Early Phase 1
33 Anti-Arrhythmia Agents Phase 4,Phase 3,Not Applicable
34 Angiotensinogen Phase 4,Phase 3,Not Applicable
35 Angiotensin II Type 1 Receptor Blockers Phase 4,Phase 3,Not Applicable
36 Autonomic Agents Phase 4,Not Applicable,Early Phase 1
37 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
38 Adrenergic beta-1 Receptor Antagonists Phase 4,Early Phase 1
39 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Early Phase 1
40 Adrenergic beta-Antagonists Phase 4,Early Phase 1
41 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
42 Adrenergic Agents Phase 4,Early Phase 1
43 Natriuretic Agents Phase 4,Phase 3,Not Applicable
44 Carbonic Anhydrase Inhibitors Phase 4
45 diuretics Phase 4,Not Applicable
46 Anticonvulsants Phase 4
47 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
48 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Analgesics, Opioid Phase 4,Phase 3,Phase 2
50 Narcotics Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 580)
# Name Status NCT ID Phase Drugs
1 Prophylactic Mesh Implantation After Abdominal Aortic Aneurysm Repair Unknown status NCT01353443 Phase 4
2 Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial) Unknown status NCT01904981 Phase 4 Beta-blocker-Atenolol 50mg, PO(peroral), Once daily;Angiotensin receptor blocker-Valsartan 80mg, PO(peroral), Once daily
3 Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
4 Effectiveness of Acetazolamide in Reducing Paralysis of the Leg in Patients Undergoing Aortic Aneurysm Surgery Surgery Unknown status NCT01889498 Phase 4 Acetazolamide
5 Endovascular Repair of Descending Thoracic Aortic Aneurysms Completed NCT00802984 Phase 4
6 Study of the Effectiveness of Telmisartan in Slowing the Progression of Abdominal Aortic Aneurysms Completed NCT01683084 Phase 4 Telmisartan;Placebo
7 Endovascular Repair of Abdominal Aortic Aneurysms Completed NCT00803075 Phase 4
8 Standard Open Surgery Versus Endovascular Repair of Abdominal Aortic Aneurysm (AAA) Completed NCT00094575 Phase 4
9 GORE EXCLUDER® Endoprosthesis - Low Permeability in Treatment of Abdominal Aortic Aneurysms Completed NCT00593814 Phase 4
10 Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities. Completed NCT02107170 Phase 4 Sevoflurane;Propofol;Remifentanil
11 Statin Use in Abdominal Aortic Aneurysm Repair Completed NCT01062802 Phase 4 Atorvastatin
12 Opioid-potentiated Volative Anaesthetic Vs. Remifentanil And Propofol During Abdominal Aortic Aneurysm Surgery Completed NCT00538421 Phase 4 Propofol;Sevoflurane
13 CUstodiol Versus RInger: whaT Is the Best Agent? Completed NCT02327611 Phase 4 Custodiol;Enriched Ringer's lactate solution
14 Prevalence of Abdominal Aortic Aneurysm in Patients Undergoing Coronary Angiography Completed NCT01239225 Phase 4
15 Epidural Versus Wound Infusion Plus Morphine Bolus in Open Abdominal Aortic Aneurysm Repair Completed NCT02677532 Phase 4 Paracetamol;Levobupivacaine wound infiltration;Levobupivacaine epidural bolus;Sufentanil epidural bolus;Morphine;Levobupivacaine plus sufentanil epidural infusion;Levobupivacaine wound infusion
16 Thoracoabdominal Arortic CTA Study Completed NCT02291718 Phase 4 Isovue
17 TAP-Block in Abdominal Aortic Surgery Completed NCT03657979 Phase 4 Ropivacaine;Placebo
18 Fibrinogen as an Alternative to FFP in Aortic Surgery. Completed NCT00994045 Phase 4
19 Vasculopathic Injury and Plasma as Endothelial Rescue - OCTAplas Trial (EudraCT no. 2014-000452-28) Completed NCT02253082 Phase 4 OctaplasLG®
20 Atorvastatin in Perioperative Vascular Surgery - Pilot Study Completed NCT00610545 Phase 4 Atorvastatin;Atorvastatin
21 A Controlled Trial of Effectiveness of a Backward Walking Program in Patients Recovering From Abdominal Aorta Surgery Completed NCT00819936 Phase 4
22 Study of Tomography of Nephrolithiasis Evaluation Completed NCT01451931 Phase 4
23 Randomized Trial of Pulsatile vs Non Pulsatile Perfusion on Short Term Changes in Kidney Function Using an Intra-Aortic Ballooon Pump During Cardioplegic Arrest in Patients Undergoing Myocardial Reperfusion Completed NCT00454428 Phase 4
24 OlmeSartan and Calcium Antagonists Randomized (OSCAR) Study Completed NCT00134160 Phase 4 Olmesartan medoxomil;Calcium channel blockers (amlodipine, azelnidipine)
25 Eplerenone in the Management of Abdominal Aortic Aneurysms Recruiting NCT02345590 Phase 4 Eplerenone
26 Predictors of AAA Expansion and/or Rupture Recruiting NCT03231397 Phase 4 Assess AAA rupture risk by PET-CTA scans;18F-fludeoxyglucose (FDG)
27 Randomized Preventive Vascular Screening Trial of 65-74 Year Old Men in the Central Region of Denmark Recruiting NCT00662480 Phase 4
28 Bloodtranfusions After Aortic Surgery Recruiting NCT02299947 Phase 4 Haemocomplettan P;Placebo
29 Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Randomized Clinical Trial Recruiting NCT02678728 Phase 4 Dexmedetomidine;normal saline
30 Pilot Study of of Renal Arterial Sympathetic Denervation by Cryotherapy Active, not recruiting NCT02345603 Phase 4
31 Tranexamic Acid in Major Vascular Surgery Active, not recruiting NCT02335359 Phase 4 tranexamic acid diluted in 100 ml of saline solution (loading dose);tranexamic acid undiluted (continous infusion);Placebo
32 Post-Market Study to Assess Outcomes of Patients Treated With AFX System Compared to Other EVAR Devices Enrolling by invitation NCT02407457 Phase 4
33 Comparison of Surveillance Versus Aortic Endografting for Small Aneurysm Repair Terminated NCT00118573 Phase 4
34 Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic Aneurysms Terminated NCT00409344 Phase 4 Dexmedetomidine
35 Long-term Benefit of Aortic Stent-graft in Patients With Distal Aortic Dissection Terminated NCT01354119 Phase 4
36 A Safety and Efficacy Study of Blood Pressure Control in Acute Aortic Emergencies - A Pilot Study (PROMPT) Terminated NCT01033370 Phase 4 clevidipine.
37 ATLANTIS:Extensive Type A Dissections and Thoracic/ Thoraco-Abdominal Aneurysms Repair With LupiAe Hybrid TechNique Withdrawn NCT01107366 Phase 4
38 NExT ERA: National Expertise Based Trial of Elective Repair of Abdominal Aortic Aneurysms: A Pilot Study Unknown status NCT00358085 Phase 3
39 34mm Cuff Study for Endovascular Repair of Abdominal Aortic Aneurysms Unknown status NCT00706394 Phase 2, Phase 3
40 Magnetic Resonance Imaging of Aortic Aneurysm Instability Unknown status NCT00794092 Phase 2, Phase 3 Sinerem administration
41 Efficacy of the Ultrasound-guided Transversus Abdominis Plane Block in Open Aortic Abdominal Aneurysm Repair Surgery Unknown status NCT02292667 Phase 3 PCA with Chlorhydrate of Morphine;Acetaminophen
42 Study of Aortic Root Reimplantation Procedure Unknown status NCT01787604 Phase 3
43 The Use of Nesiritide in Thoracic Aneurysm Repair to Prevent Acute Renal Failure Unknown status NCT00110201 Phase 3 Nesiritide
44 Clinical Evaluation of a Modular Extracorporeal Circulation Circuit Unknown status NCT02000544 Phase 3
45 Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) Trial of Cardiovascular Events in High-Risk Hypertensive Patients Unknown status NCT00125463 Phase 3 Candesartan cilexetil
46 Study of the Endovascular QUANTUM LP™ Stent Graft System in Abdominal Aortic Aneurysms (AAA) Completed NCT00233688 Phase 3
47 Curcumin to Prevent Complications After Elective Abdominal Aortic Aneurysm (AAA) Repair Completed NCT01225094 Phase 2, Phase 3 curcumin
48 Prevention of Colon Ischemia During Aortic Aneurysm (AAA) Repair Completed NCT00671203 Phase 3
49 ARBITER-II: Aorfix™ Bifurcated Safety and Performance Trial: Phase II, Angulated Vessels Completed NCT00442065 Phase 2, Phase 3
50 Melatonin and Cardiac Outcome After Major Surgery Completed NCT00315926 Phase 2, Phase 3 Melatonin;Placebo

Search NIH Clinical Center for Aortic Aneurysm

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: aortic aneurysm

Genetic Tests for Aortic Aneurysm

Genetic tests related to Aortic Aneurysm:

# Genetic test Affiliating Genes
1 Aortic Aneurysm 29

Anatomical Context for Aortic Aneurysm

MalaCards organs/tissues related to Aortic Aneurysm:

41
Kidney, Heart, Lung, Spinal Cord, Testes, Endothelial, Smooth Muscle

Publications for Aortic Aneurysm

Articles related to Aortic Aneurysm:

(show top 50) (show all 4259)
# Title Authors Year
1
Renal cystic disease in the Fbn1C1039G/+ Marfan mouse is associated with enhanced aortic aneurysm formation. ( 30359839 )
2019
2
A FBN1 3'UTR mutation variant is associated with endoplasmic reticulum stress in aortic aneurysm in Marfan syndrome. ( 30385411 )
2019
3
Concomitant mycotic abdominal aortic aneurysm and lumbartuberculous spondylitis with cauda equina syndrome: a rare condition - a case report and literature review. ( 29479482 )
2018
4
Giant dissecting aortic aneurysm in a chronic amphetamine user. ( 29975172 )
2018
5
Ten-year experience of the thoraco-abdominal aortic aneurysm treatment using a hybrid thoracic endovascular aortic repair. ( 29415193 )
2018
6
Modulation of Immune-Inflammatory Responses in Abdominal Aortic Aneurysm: Emerging Molecular Targets. ( 29967801 )
2018
7
Thoracic aortic aneurysm is an independent factor associated with diffuse idiopathic skeletal hyperostosis. ( 29701101 )
2018
8
A case of a rectal stricture related to ischemic proctitis following rupture of an aortic aneurysm. ( 29399616 )
2018
9
Endovascular treatment of thoracoabdominal aortic aneurysm in Loeys-Dietz syndrome. ( 29756196 )
2018
10
Renal Fenestration Closure Technique in fenestrated endovascular repair for para-renal aortic aneurysm. ( 29421424 )
2018
11
The Effect of a Non-peptide Angiotensin II type 2 receptor Agonist, Compound 21, on Aortic Aneurysm Growth in a Mouse Model of Marfan Syndrome. ( 29300219 )
2018
12
Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm. ( 29432192 )
2018
13
Comparative effectiveness of open surgery versus endovascular repair for hemodynamically stable and unstable ruptured abdominal aortic aneurysm. ( 29979402 )
2018
14
Understanding abdominal aortic aneurysm epidemiology: socioeconomic position affects outcome. ( 29967003 )
2018
15
Patients with end-stage renal disease have poor outcomes after endovascular abdominal aortic aneurysm repair. ( 29945838 )
2018
16
Screening for Abdominal Aortic Aneurysm During Transthoracic Echocardiography: A Systematic Review and Meta-analysis. ( 29433798 )
2018
17
Systematic Review of Circulating, Biomechanical, and Genetic Markers for the Prediction of Abdominal Aortic Aneurysm Growth and Rupture. ( 29960996 )
2018
18
Increased risk of malignancy in patients with an aortic aneurysm: a nationwide population-based retrospective study. ( 29416815 )
2018
19
Abdominal compartment syndrome and ruptured aortic aneurysm: Validation of a predictive test (SCA-AAR). ( 29923999 )
2018
20
Impact of abdominal aortic aneurysm screening on quality ofA life. ( 29405273 )
2018
21
Defective p27 phosphorylation at serine 10 affects vascular reactivity and increases abdominal aortic aneurysm development via Cox-2 activation. ( 29408196 )
2018
22
MiR-155 deletion reduces ischemia-induced paralysis in an aortic aneurysm repair mouse model: Utility of immunohistochemistry and histopathology in understanding etiology of spinal cord paralysis. ( 29966831 )
2018
23
Early growth response factor-1 DNA enzyme 1 inhibits the formation of abdominal aortic aneurysm in rats. ( 29977360 )
2018
24
Aortitis as a Rare Cause of Aortic Aneurysm and Valve Regurgitation: Is Repair Precluded? ( 29662705 )
2018
25
Association of carotid atherosclerosis and stiffness with abdominal aortic aneurysm: The atherosclerosis risk in communities (ARIC) study. ( 29407878 )
2018
26
The Association of Biomarkers of Inflammation and Extracellular Matrix Degradation With the Risk of Abdominal Aortic Aneurysm: The ARIC Study. ( 29945457 )
2018
27
Case Image: Treatment of aortic coarctation, saccular thoracic aortic aneurysm, and corresponding feeding collateral vessel with a fully percutaneous endovascular approach. ( 29664433 )
2018
28
Impact of Medical Therapy on Late Morbidity and Mortality After Aortic Aneurysm Repair for Aortitis. ( 29408240 )
2018
29
Endovascular repair for inflammatory abdominal aortic aneurysm. ( 29945204 )
2018
30
Aortic Aneurysm as a Complication of Granulomatosis with Polyangiitis Successfully Treated with Prednisolone and Cyclophosphamide: A Case Report and Review of the Literature. ( 29971178 )
2018
31
Postoperative Chylothorax after Thoracoabdominal Aortic Aneurysm Repair. ( 29428620 )
2018
32
Embelin inhibits abdominal aortic aneurysm through decreasing ILa896a89induced STAT3 and NFa89I_B inactivation. ( 29956759 )
2018
33
Bacille Calmette-GuAcrin (BCG) spondylitis with adjacent mycotic aortic aneurysm after intravesical BCG therapy: a case report and literature review. ( 29954321 )
2018
34
Spinal cord injury in endovascular thoracoabdominal aortic aneurysm repair: prevalence, risk factors and preventive strategies. ( 29424186 )
2018
35
A custom-made TreovanceAr abdominal aortic aneurysm endograft to correct late failure of trombone technique with a tube endograft. ( 29421425 )
2018
36
Thiol/disulphide homeostasis in thoracic aortic aneurysm and acute aortic syndrome. ( 29436236 )
2018
37
Rare Case of Both Left Atrial and Ventricular Compression by Dissecting Aortic Aneurysm. ( 29952308 )
2018
38
The incidence of incisional hernia after aortic aneurysm is not higher than after benign colorectal interventions: AA retrospective control-matched cohort study. ( 29950793 )
2018
39
Increased Risk of Peripheral Arterial Disease in Patients With Abdominal Aortic Aneurysm: A Retrospective Cohort Study (Version 5). ( 29444589 )
2018
40
Snorkel Technique for Inferior Mesenteric Artery During Endovascular Repair of Abdominal Aortic Aneurysm. ( 29433410 )
2018
41
Combination of Octopus and Periscope Techniques for the Management of Visceral Branches From Type V Thoracoabdominal Aortic Aneurysm: A Case Report. ( 29954257 )
2018
42
Abdominal aortic aneurysm calcification: trying to identify a reliable semiquantitative method. ( 29430885 )
2018
43
Macrophage CD31 Signaling in DissectingA Aortic Aneurysm. ( 29957231 )
2018
44
Double Inferior Vena Cava with Azygos Continuation and Retroaortic Left Renal Vein Associated with Juxtarenal Abdominal Aortic Aneurysm Surgery. ( 29682119 )
2018
45
Screening key genes for abdominal aortic aneurysm based on gene expression omnibus dataset. ( 29439675 )
2018
46
Ischemic Preconditioning of the Spinal Cord to Prevent Spinal Cord Ischemia during Endovascular Repair of Thoraco-Abdominal Aortic Aneurysm - First Clinical Experience. ( 29969429 )
2018
47
Rupture of an Abdominal Aortic Aneurysm in a Young Man with Marfan Syndrome. ( 29421423 )
2018
48
An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm. ( 29520069 )
2018
49
Nationwide analysis of risk factors for in-hospital mortality in patients undergoing abdominal aortic aneurysm repair. ( 29417985 )
2018
50
Clinical outcomes of total endovascular aneurysm repair for aortic aneurysms involving the proximal anastomotic aneurysm following initial open repair for infrarenal abdominal aortic aneurysm. ( 29421415 )
2018

Variations for Aortic Aneurysm

ClinVar genetic disease variations for Aortic Aneurysm:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 COL3A1 NM_000090.3(COL3A1): c.505C> T (p.Leu169Phe) single nucleotide variant Conflicting interpretations of pathogenicity rs111391222 GRCh37 Chromosome 2, 189851842: 189851842
2 COL3A1 NM_000090.3(COL3A1): c.505C> T (p.Leu169Phe) single nucleotide variant Conflicting interpretations of pathogenicity rs111391222 GRCh38 Chromosome 2, 188987116: 188987116
3 MYH11 NM_001040113.1(MYH11): c.4963C> T (p.Arg1655Cys) single nucleotide variant Uncertain significance rs369409348 GRCh37 Chromosome 16, 15814019: 15814019
4 MYH11 NM_001040113.1(MYH11): c.4963C> T (p.Arg1655Cys) single nucleotide variant Uncertain significance rs369409348 GRCh38 Chromosome 16, 15720162: 15720162
5 FBN1 NM_000138.4(FBN1): c.7754T> C (p.Ile2585Thr) single nucleotide variant Pathogenic/Likely pathogenic rs727503054 GRCh37 Chromosome 15, 48712949: 48712949
6 FBN1 NM_000138.4(FBN1): c.7754T> C (p.Ile2585Thr) single nucleotide variant Pathogenic/Likely pathogenic rs727503054 GRCh38 Chromosome 15, 48420752: 48420752
7 TGFB2 NM_003238.3(TGFB2): c.356C> T (p.Pro119Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs149533093 GRCh37 Chromosome 1, 218578520: 218578520
8 TGFB2 NM_003238.3(TGFB2): c.356C> T (p.Pro119Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs149533093 GRCh38 Chromosome 1, 218405178: 218405178

Expression for Aortic Aneurysm

Search GEO for disease gene expression data for Aortic Aneurysm.

Pathways for Aortic Aneurysm

Pathways related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 46)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 ACTA2 COL3A1 EFEMP2 ELN FBN1 FBN2
2
Show member pathways
13.2 ACTA2 MYH11 MYLK NOTCH1 SLC2A10 SMAD3
3
Show member pathways
13.14 ACTA2 COL3A1 EFEMP2 ELN FBN1 FBN2
4
Show member pathways
13.01 ACTA2 COL3A1 PRKG1 SMAD3 TGFBR1 TGFBR2
5
Show member pathways
12.95 ACTA2 COL3A1 EFEMP2 ELN FBN1 FBN2
6
Show member pathways
12.88 ACTA2 MYH11 PRKG1 TGFB2 TGFBR1 TGFBR2
7
Show member pathways
12.83 ACTA2 MYLK TGFB2 TGFBR1 TGFBR2
8 12.8 NOTCH1 SMAD3 TGFB2 TGFBR1 TGFBR2
9
Show member pathways
12.74 NOTCH1 SMAD3 TGFB2 TGFBR1 TGFBR2
10
Show member pathways
12.56 NOTCH1 SMAD3 TGFB2 TGFBR1 TGFBR2
11
Show member pathways
12.48 SMAD3 TGFB2 TGFBR1 TGFBR2
12
Show member pathways
12.46 BGN COL3A1 EFEMP2 ELN FBN1 FBN2
13
Show member pathways
12.44 SMAD3 TGFB2 TGFBR1 TGFBR2
14 12.39 SMAD3 TGFB2 TGFBR1 TGFBR2
15 12.22 NOTCH1 SMAD3 TGFB2 TGFBR1
16
Show member pathways
12.2 SMAD3 TGFB2 TGFBR1 TGFBR2
17 12.16 SMAD3 TGFB2 TGFBR1 TGFBR2
18 12.14 SMAD3 TGFB2 TGFBR1 TGFBR2
19 12.12 SMAD3 TGFB2 TGFBR1 TGFBR2
20
Show member pathways
12.05 SMAD3 TGFB2 TGFBR1 TGFBR2
21 12.04 ACTA2 MYLK SMAD3 TGFBR1
22
Show member pathways
12.03 ACTA2 COL3A1 EFEMP2 ELN FBN1 FBN2
23
Show member pathways
12.01 SMAD3 TGFB2 TGFBR1 TGFBR2
24 12 ACTA2 SMAD3 TGFB2 TGFBR1 TGFBR2
25 11.85 SMAD3 TGFB2 TGFBR1 TGFBR2
26
Show member pathways
11.83 SMAD3 TGFBR1 TGFBR2
27 11.81 NOTCH1 TGFB2 TGFBR1
28 11.8 COL3A1 SMAD3 TGFB2 TGFBR1 TGFBR2
29 11.77 SMAD3 TGFB2 TGFBR1 TGFBR2
30
Show member pathways
11.72 LOX SMAD3 TGFBR1 TGFBR2
31 11.71 SMAD3 TGFBR1 TGFBR2
32 11.71 SMAD3 TGFBR1 TGFBR2
33
Show member pathways
11.69 SMAD3 TGFBR1 TGFBR2
34 11.64 ACTA2 SMAD3 TGFB2 TGFBR1 TGFBR2
35 11.6 SMAD3 TGFBR1 TGFBR2
36
Show member pathways
11.58 SMAD3 TGFB2 TGFBR1 TGFBR2
37 11.53 SMAD3 TGFBR1 TGFBR2
38 11.51 TGFB2 TGFBR1 TGFBR2
39 11.46 TGFB2 TGFBR1 TGFBR2
40 11.35 ACTA2 MYLK TGFB2 TGFBR1 TGFBR2
41 11.33 ACTA2 MYH11 MYLK
42 11.15 SMAD3 TGFB2 TGFBR1 TGFBR2
43 11.06 SMAD3 TGFBR1 TGFBR2
44
Show member pathways
11.03 EFEMP2 ELN FBN1 FBN2 LOX MFAP5
45 10.94 COL3A1 EFEMP2 ELN FBN1 FBN2 MYLK
46 10.75 FBN1 FBN2 SMAD3 TGFBR1 TGFBR2

GO Terms for Aortic Aneurysm

Cellular components related to Aortic Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.96 BGN COL3A1 EFEMP2 ELN FBN1 FBN2
2 receptor complex GO:0043235 9.67 NOTCH1 SMAD3 TGFBR1 TGFBR2
3 extracellular matrix GO:0031012 9.5 BGN COL3A1 ELN FBN1 FBN2 LOX
4 microfibril GO:0001527 9.33 FBN1 FBN2 MFAP5
5 transforming growth factor beta receptor complex GO:0070022 9.32 TGFBR1 TGFBR2
6 collagen-containing extracellular matrix GO:0062023 9.17 BGN COL3A1 ELN FBN1 FBN2 MFAP5

Biological processes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 49)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.95 CDKN2B-AS1 MYLK NOTCH1 SMAD3 TGFBR1
2 in utero embryonic development GO:0001701 9.94 NOTCH1 SMAD3 TGFBR1 TGFBR2
3 kidney development GO:0001822 9.88 FBN1 TGFB2 TGFBR1
4 muscle contraction GO:0006936 9.88 ACTA2 MYH11 MYLK
5 cell cycle arrest GO:0007050 9.88 NOTCH1 SMAD3 TGFB2 TGFBR1
6 skeletal system development GO:0001501 9.88 COL3A1 FBN1 SMAD3 TGFB2 TGFBR1
7 lung development GO:0030324 9.86 LOX NOTCH1 TGFBR2
8 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.83 SMAD3 TGFBR1 TGFBR2
9 cellular response to transforming growth factor beta stimulus GO:0071560 9.81 FBN1 SMAD3 TGFBR1
10 heart looping GO:0001947 9.8 NOTCH1 SMAD3 TGFBR2
11 embryonic limb morphogenesis GO:0030326 9.8 FBN2 NOTCH1 TGFB2
12 extracellular matrix organization GO:0030198 9.8 BGN COL3A1 ELN FBN1 FBN2 MFAP5
13 outflow tract morphogenesis GO:0003151 9.79 ELN NOTCH1 TGFBR2
14 transforming growth factor beta receptor signaling pathway GO:0007179 9.77 COL3A1 SMAD3 TGFB2 TGFBR1 TGFBR2
15 epithelial to mesenchymal transition GO:0001837 9.74 NOTCH1 TGFB2 TGFBR1
16 embryonic cranial skeleton morphogenesis GO:0048701 9.73 SMAD3 TGFBR1 TGFBR2
17 collagen fibril organization GO:0030199 9.73 COL3A1 LOX TGFB2 TGFBR1
18 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.71 TGFBR1 TGFBR2
19 ventricular trabecula myocardium morphogenesis GO:0003222 9.71 NOTCH1 TGFB2 TGFBR1
20 ventricular septum morphogenesis GO:0060412 9.71 NOTCH1 TGFB2 TGFBR1 TGFBR2
21 smooth muscle contraction GO:0006939 9.7 MYH11 MYLK
22 activin receptor signaling pathway GO:0032924 9.7 SMAD3 TGFBR1
23 cardiac epithelial to mesenchymal transition GO:0060317 9.7 NOTCH1 TGFB2 TGFBR1
24 heart development GO:0007507 9.7 COL3A1 FBN1 LOX NOTCH1 TGFB2 TGFBR1
25 endocardial cushion morphogenesis GO:0003203 9.69 NOTCH1 TGFB2
26 regulation of epithelial cell proliferation GO:0050678 9.69 NOTCH1 SMAD3
27 pathway-restricted SMAD protein phosphorylation GO:0060389 9.69 TGFB2 TGFBR1 TGFBR2
28 cardiac muscle cell proliferation GO:0060038 9.68 NOTCH1 TGFB2
29 negative regulation of immune response GO:0050777 9.68 COL3A1 TGFB2
30 pulmonary valve morphogenesis GO:0003184 9.68 NOTCH1 TGFB2
31 secondary palate development GO:0062009 9.68 TGFB2 TGFBR2
32 supramolecular fiber organization GO:0097435 9.67 COL3A1 MFAP5
33 cardiac left ventricle morphogenesis GO:0003214 9.67 NOTCH1 TGFBR2
34 membranous septum morphogenesis GO:0003149 9.67 TGFB2 TGFBR2
35 atrioventricular valve morphogenesis GO:0003181 9.67 NOTCH1 TGFB2 TGFBR2
36 response to cholesterol GO:0070723 9.66 TGFBR1 TGFBR2
37 somatic stem cell division GO:0048103 9.66 NOTCH1 TGFB2
38 coronary artery morphogenesis GO:0060982 9.65 NOTCH1 TGFBR1
39 embryonic eye morphogenesis GO:0048048 9.65 FBN1 FBN2
40 elastic fiber assembly GO:0048251 9.63 EFEMP2 LOX MYH11
41 aorta smooth muscle tissue morphogenesis GO:0060414 9.61 COL3A1 MYLK
42 endocardial cushion fusion GO:0003274 9.61 TGFB2 TGFBR2
43 glomerular mesangial cell development GO:0072144 9.6 ACTA2 NOTCH1
44 regulation of transforming growth factor beta2 production GO:0032909 9.59 SMAD3 TGFB2
45 sequestering of TGFbeta in extracellular matrix GO:0035583 9.58 FBN1 FBN2
46 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.43 TGFB2 TGFBR1 TGFBR2
47 positive regulation of epithelial to mesenchymal transition GO:0010718 9.35 NOTCH1 SMAD3 TGFB2 TGFBR1 TGFBR2
48 wound healing GO:0042060 9.1 COL3A1 LOX SMAD3 TGFB2 TGFBR1 TGFBR2
49 positive regulation of gene expression GO:0010628 10.04 ACTA2 CDKN2B-AS1 NOTCH1 SMAD3 TGFBR1

Molecular functions related to Aortic Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SMAD binding GO:0046332 9.46 COL3A1 SMAD3 TGFBR1 TGFBR2
2 transforming growth factor beta-activated receptor activity GO:0005024 9.37 TGFBR1 TGFBR2
3 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.32 TGFBR1 TGFBR2
4 type II transforming growth factor beta receptor binding GO:0005114 9.26 TGFB2 TGFBR1
5 extracellular matrix structural constituent GO:0005201 9.17 BGN COL3A1 EFEMP2 ELN FBN1 FBN2
6 extracellular matrix constituent conferring elasticity GO:0030023 9.13 ELN FBN1 FBN2

Sources for Aortic Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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