Aortic Aneurysm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ART016 MIFTS: 71	Aortic Aneurysm Categories: Blood diseases, Cardiovascular diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Aortic Aneurysm

MalaCards integrated aliases for Aortic Aneurysm:

Name: Aortic Aneurysm ¹² ⁷⁷ ³⁰ ⁶ ⁴⁴ ³ ⁴⁵ ¹⁵ ¹⁷ ⁷⁴

Aortic Rupture ⁴⁵ ¹⁷ ⁷⁴

Thoracoabdominal Aortic Aneurysm, Ruptured ¹² ⁷⁴

Ruptured Abdominal Aortic Aneurysm ¹² ⁷⁴

Ruptured Thoracic Aortic Aneurysm ¹² ⁷⁴

Aortic Aneurysm Without Mention of Rupture Nos ⁷⁴

Thoracic Aortic Aneurysm Which Has Ruptured ¹²

Ruptured Thoracoabdominal Aortic Aneurysm ¹²

Abdominal Aortic Aneurysm, Ruptured ¹²

Thoracic Aortic Aneurysm, Ruptured ¹²

Ruptured Thoracic Aneurysm ¹²

Aortic Aneurysm, Ruptured ⁷⁴

Ruptured Aortic Aneurysm ¹²

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the circulatory system

Diseases of arteries, arterioles and capillaries

Aortic aneurysm and dissection

Abdominal aortic aneurysm, ruptured

Aortic aneurysm of unspecified site, ruptured

Aortic aneurysm of unspecified site, without mention of rupture

Thoracic aortic aneurysm, ruptured

Thoracoabdominal aortic aneurysm, ruptured

External Ids:

Disease Ontology ¹² DOID:3627

ICD9CM ³⁶ 441.1 441.3 441.5 more

MeSH ⁴⁵ D001014 D001019

NCIt ⁵¹ C26697 C27046 C27198 more

SNOMED-CT ⁶⁹ 14336007 34365005 67362008 more

ICD10 ³⁴ I71.1 I71.3 I71.5 more

EFO ¹⁷ EFO_0001666 EFO_1001268

UMLS ⁷⁴ C0003486 C0003496 C0265010 more

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Summaries for Aortic Aneurysm

MedlinePlus : ⁴⁴ An aneurysm is a bulge or "ballooning" in the wall of an artery. Arteries are blood vessels that carry oxygen-rich blood from the heart to other parts of the body. If an aneurysm grows large, it can burst and cause dangerous bleeding or even death. Most aneurysms are in the aorta, the main artery that runs from the heart through the chest and abdomen. There are two types of aortic aneurysm: Thoracic aortic aneurysms (TAA) - these occur in the part of the aorta running through the chest Abdominal aortic aneurysms (AAA) - these occur in the part of the aorta running through the abdomen Most aneurysms are found during tests done for other reasons. Some people are at high risk for aneurysms. It is important for them to get screening, because aneurysms can develop and become large before causing any symptoms. Screening is recommended for people between the ages of 65 and 75 if they have a family history, or if they are men who have smoked. Doctors use imaging tests to find aneurysms. Medicines and surgery are the two main treatments. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Aortic Aneurysm, also known as aortic rupture, is related to aortic aneurysm, familial thoracic 6 and aortic aneurysm, familial abdominal, 1, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Aortic Aneurysm is FBN1 (Fibrillin 1), and among its related pathways/superpathways are ERK Signaling and PAK Pathway. The drugs Acetazolamide and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and spinal cord, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : ¹² An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size.

CDC : ³ An aortic aneurysm is a balloon-like bulge in the aorta, the large artery that carries blood from the heart through the chest and torso.

Wikipedia : ⁷⁷ An aortic aneurysm is an enlargement (dilatation) of the aorta to greater than 1.5 times normal size.... more...

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Related Diseases for Aortic Aneurysm

Diseases related to Aortic Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 485)

#	Related Disease	Score	Top Affiliating Genes
1	aortic aneurysm, familial thoracic 6	34.6	ACTA2 MYH11 MYLK
2	aortic aneurysm, familial abdominal, 1	34.4	CDKN2B-AS1 ELN FBN1
3	familial thoracic aortic aneurysm and dissection	34.3	COL3A1 FBN1 SMAD3 TGFBR1 TGFBR2
4	familial abdominal aortic aneurysm	34.0	COL3A1 ELN FBN1 MYLK
5	aortic aneurysm, familial thoracic 2	33.8	ACTA2 FBN1 SLC2A10
6	loeys-dietz syndrome 2	33.5	MYH11 TGFBR2
7	loeys-dietz syndrome 1	33.3	COL3A1 FBN1 MYH11 SMAD3 TGFB2 TGFBR1
8	aortic aneurysm, familial thoracic 1	32.9	ACTA2 COL3A1 EFEMP2 ELN FBN1 HIF1A-AS1
9	loeys-dietz syndrome	32.7	ACTA2 COL3A1 FBN1 FBN2 MYH11 MYLK
10	loeys-dietz syndrome 4	32.6	SMAD3 TGFB2 TGFBR1 TGFBR2
11	marfan syndrome	32.1	ACTA2 COL3A1 ELN FBN1 FBN2 TGFBR1
12	cutis laxa, autosomal recessive, type ib	32.1	EFEMP2 ELN LOX
13	autosomal recessive cutis laxa type i	32.0	EFEMP2 ELN LOX TGFBR1 TGFBR2
14	loeys-dietz syndrome 3	31.4	ACTA2 COL3A1 FBN1 LOX MYH11 MYLK
15	aortic valve insufficiency	30.9	ELN FBN1 NOTCH1
16	aortic valve disease 1	30.7	ACTA2 ELN FBN1 FBN2 NOTCH1 TGFBR2
17	ehlers-danlos syndrome, vascular type	30.6	COL3A1 ELN
18	exfoliation syndrome	30.2	ELN FBN1 LOX
19	arterial tortuosity syndrome	29.9	EFEMP2 ELN SLC2A10 TGFBR1
20	connective tissue disease	29.7	ACTA2 COL3A1 ELN FBN1 FBN2
21	intracranial aneurysm	29.5	CDKN2B-AS1 COL3A1 ELN FBN2 LOX
22	cerebral arterial disease	29.4	ACTA2 CDKN2B-AS1 ELN
23	aortic disease	29.2	ACTA2 EFEMP2 ELN FBN1 MYH11 NOTCH1
24	aortic aneurysm, familial thoracic 4	12.7
25	aortic aneurysm, familial thoracic 10	12.7
26	aortic aneurysm, familial thoracic 9	12.7
27	aortic aneurysm, familial thoracic 11	12.7
28	aortic aneurysm, familial thoracic 8	12.6
29	aortic aneurysm, familial thoracic 7	12.6
30	aortic aneurysm, familial abdominal, 2	12.3
31	aortic aneurysm, familial abdominal, 4	12.3
32	aortic aneurysm, familial abdominal, 3	12.3
33	cutis laxa, autosomal dominant 1	11.6
34	meester-loeys syndrome	11.6
35	temporal arteritis	11.5
36	loeys-dietz syndrome 5	11.5
37	multisystemic smooth muscle dysfunction syndrome	11.5
38	phace association	11.2
39	cutis laxa, autosomal dominant 2	11.2
40	cutis laxa, autosomal dominant 3	11.2
41	cystic medial necrosis of aorta	11.2
42	ischemia	10.7
43	horseshoe kidney	10.7
44	paraplegia	10.6
45	peripheral vascular disease	10.5
46	aortic coarctation	10.5
47	arteries, anomalies of	10.5
48	aortitis	10.5
49	disseminated intravascular coagulation	10.5
50	compartment syndrome	10.4

Comorbidity relations with Aortic Aneurysm via Phenotypic Disease Network (PDN): (show all 15)

Acute Cystitis	Acute Kidney Failure
Acute Vascular Insufficiency of Intestine	Aortic Valve Disease 1
Cardiac Arrest	Chronic Myocardial Ischemia
Deficiency Anemia	Familial Atrial Fibrillation
Heart Disease	Hypertension, Essential
Intermediate Coronary Syndrome	Ischemic Heart Disease
Paralytic Ileus	Peripheral Vascular Disease
Respiratory Failure

Graphical network of the top 20 diseases related to Aortic Aneurysm:

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Symptoms & Phenotypes for Aortic Aneurysm

UMLS symptoms related to Aortic Aneurysm:

angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

²⁷ (show all 27)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-104	10.05	TGFBR2
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-14	10.05	TGFB2
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-141	10.05	TGFB2
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-145	10.05	PRKG1 TGFBR2
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-153	10.05	TGFBR2
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-165	10.05	TGFBR1 TGFBR2
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-180	10.05	TGFBR1
8	Decreased shRNA abundance (Z-score < -2)	GR00366-A-20	10.05	TGFBR2
9	Decreased shRNA abundance (Z-score < -2)	GR00366-A-200	10.05	TGFBR1
10	Decreased shRNA abundance (Z-score < -2)	GR00366-A-216	10.05	PRKG1
11	Decreased shRNA abundance (Z-score < -2)	GR00366-A-22	10.05	TGFBR1
12	Decreased shRNA abundance (Z-score < -2)	GR00366-A-26	10.05	TGFB2
13	Decreased shRNA abundance (Z-score < -2)	GR00366-A-48	10.05	TGFBR2
14	Decreased shRNA abundance (Z-score < -2)	GR00366-A-59	10.05	TGFB2
15	Decreased shRNA abundance (Z-score < -2)	GR00366-A-60	10.05	PRKG1 TGFB2 TGFBR1 TGFBR2
16	Decreased shRNA abundance (Z-score < -2)	GR00366-A-71	10.05	TGFB2
17	Decreased shRNA abundance (Z-score < -2)	GR00366-A-72	10.05	TGFB2
18	Decreased shRNA abundance (Z-score < -2)	GR00366-A-75	10.05	PRKG1
19	Decreased shRNA abundance (Z-score < -2)	GR00366-A-77	10.05	TGFBR1
20	Decreased shRNA abundance (Z-score < -2)	GR00366-A-84	10.05	TGFBR2
21	Decreased viability	GR00107-A-1	9.92	TGFBR2
22	Decreased viability	GR00221-A-1	9.92	COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
23	Decreased viability	GR00221-A-2	9.92	COL3A1 PRKG1
24	Decreased viability	GR00221-A-3	9.92	TGFBR2
25	Decreased viability	GR00221-A-4	9.92	COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
26	Decreased viability	GR00301-A	9.92	PRKG1
27	Decreased viability	GR00402-S-2	9.92	COL3A1 MYLK PRKG1 TGFBR1 TGFBR2

MGI Mouse Phenotypes related to Aortic Aneurysm:

⁴⁷ (show all 13)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.43	ACTA2 COL3A1 EFEMP2 FBN1 FBN2 LOX
2	cellular	MP:0005384	10.29	BGN COL3A1 EFEMP2 FBN1 FBN2 MYH11
3	homeostasis/metabolism	MP:0005376	10.25	BGN COL3A1 FBN1 FBN2 LOX MYH11
4	growth/size/body region	MP:0005378	10.2	BGN COL3A1 FBN1 FBN2 MYH11 MYLK
5	immune system	MP:0005387	10.18	BGN COL3A1 FBN1 MFAP5 MYLK NOTCH1
6	mortality/aging	MP:0010768	10.17	BGN COL3A1 EFEMP2 FBN1 FBN2 LOX
7	digestive/alimentary	MP:0005381	10.13	COL3A1 MYH11 MYLK NOTCH1 PRKG1 SMAD3
8	muscle	MP:0005369	10.1	ACTA2 BGN COL3A1 EFEMP2 FBN1 FBN2
9	craniofacial	MP:0005382	10.04	BGN FBN1 FBN2 NOTCH1 SMAD3 TGFB2
10	integument	MP:0010771	10.02	BGN COL3A1 EFEMP2 FBN1 LOX MYH11
11	renal/urinary system	MP:0005367	9.76	FBN1 MYH11 MYLK NOTCH1 PRKG1 SLC2A10
12	respiratory system	MP:0005388	9.7	COL3A1 EFEMP2 FBN1 FBN2 LOX MYH11
13	skeleton	MP:0005390	9.36	BGN EFEMP2 FBN1 FBN2 MFAP5 MYLK

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Drugs & Therapeutics for Aortic Aneurysm

Drugs for Aortic Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 286)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Acetazolamide

Approved, Vet_approved

Phase 4

59-66-5

1986

Angiotensin II

Approved, Investigational

Phase 4,Phase 3,Not Applicable

11128-99-7, 68521-88-0, 4474-91-3

172198

Atorvastatin

Approved

Phase 4,Phase 3,Phase 2

134523-00-5

60823

Morphine

Approved, Investigational

Phase 4,Phase 3

57-27-2

5288826

Acetaminophen

Approved

Phase 4,Phase 3

103-90-2

1983

Iodine

Approved, Investigational

Phase 4,Not Applicable

7553-56-2

807

Ropivacaine

Approved

Phase 4,Phase 3

84057-95-4

175805 71273

Amlodipine

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

88150-42-9

2162

Telmisartan

Approved, Investigational

Phase 4

144701-48-4

65999

Valsartan

Approved, Investigational

Phase 4

137862-53-4

60846

Atenolol

Approved

Phase 4

29122-68-7

2249

Sevoflurane

Approved, Vet_approved

Phase 4

28523-86-6

5206

Propofol

Approved, Investigational, Vet_approved

Phase 4,Not Applicable

2078-54-8

4943

Remifentanil

Approved

Phase 4,Phase 2

132875-61-7

60815

Prednisolone

Approved, Vet_approved

Phase 4,Not Applicable

50-24-8

5755

Prednisolone phosphate

Approved, Vet_approved

Phase 4,Not Applicable

302-25-0

Methylprednisolone

Approved, Vet_approved

Phase 4,Not Applicable

83-43-2

6741

Mannitol

Approved, Investigational

Phase 4

69-65-8

6251 453

Methylprednisolone hemisuccinate

Approved

Phase 4,Not Applicable

2921-57-5

Sufentanil

Approved, Investigational

Phase 4

56030-54-7

41693

Levobupivacaine

Approved, Investigational

Phase 4

27262-47-1

92253

Tranexamic Acid

Approved

Phase 4,Phase 3

1197-18-8

5526

Olmesartan

Approved, Investigational

Phase 4

144689-24-7, 144689-63-4

158781 130881

Desflurane

Approved

Phase 4

57041-67-5

42113

Eplerenone

Approved

Phase 4

107724-20-9

443872 150310

Dexmedetomidine

Approved, Vet_approved

Phase 4

113775-47-6

5311068 68602

Clevidipine

Approved, Investigational

Phase 4,Not Applicable

167221-71-8

Calcium

Approved, Nutraceutical

Phase 4,Phase 2,Phase 3,Not Applicable

7440-70-2

271

Histidine

Approved, Nutraceutical

Phase 4

71-00-1

6274

Prednisolone hemisuccinate

Experimental

Phase 4,Not Applicable

2920-86-7

Carbonic Anhydrase Inhibitors

Phase 4

Natriuretic Agents

Phase 4,Phase 3,Not Applicable

diuretics

Phase 4,Not Applicable

Anticonvulsants

Phase 4

Angiotensin II Type 1 Receptor Blockers

Phase 4,Phase 3,Not Applicable

Angiotensin Receptor Antagonists

Phase 4,Phase 3,Not Applicable

Antihypertensive Agents

Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable

Giapreza

Phase 4,Phase 3,Not Applicable

Angiotensinogen

Phase 4,Phase 3,Not Applicable

Peripheral Nervous System Agents

Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1

Anesthetics

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Central Nervous System Depressants

Phase 4,Phase 3,Phase 2,Not Applicable

Analgesics

Phase 4,Phase 3,Phase 2,Not Applicable

Analgesics, Opioid

Phase 4,Phase 3,Phase 2

Narcotics

Phase 4,Phase 3,Phase 2

Lipid Regulating Agents

Phase 4,Phase 3,Phase 2

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Phase 4,Phase 3,Phase 2

Antimetabolites

Phase 4,Phase 3,Phase 2,Phase 1

Anticholesteremic Agents

Phase 4,Phase 3,Phase 2

Hypolipidemic Agents

Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 612)

#	Name	Status	NCT ID	Phase	Drugs
1	Prophylactic Mesh Implantation After Abdominal Aortic Aneurysm Repair	Unknown status	NCT01353443	Phase 4
2	Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair	Unknown status	NCT00339053	Phase 4	Immunonutrition ( Impact)
3	Effectiveness of Acetazolamide in Reducing Paralysis of the Leg in Patients Undergoing Aortic Aneurysm Surgery Surgery	Unknown status	NCT01889498	Phase 4	Acetazolamide
4	Endovascular Repair of Descending Thoracic Aortic Aneurysms	Completed	NCT00802984	Phase 4
5	Study of the Effectiveness of Telmisartan in Slowing the Progression of Abdominal Aortic Aneurysms	Completed	NCT01683084	Phase 4	Telmisartan;Placebo
6	Endovascular Repair of Abdominal Aortic Aneurysms	Completed	NCT00803075	Phase 4
7	Standard Open Surgery Versus Endovascular Repair of Abdominal Aortic Aneurysm (AAA)	Completed	NCT00094575	Phase 4
8	GORE EXCLUDER® Endoprosthesis - Low Permeability in Treatment of Abdominal Aortic Aneurysms	Completed	NCT00593814	Phase 4
9	Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial)	Completed	NCT01904981	Phase 4	Beta-blocker-Atenolol 50mg, PO(peroral), Once daily;Angiotensin receptor blocker-Valsartan 80mg, PO(peroral), Once daily
10	Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities.	Completed	NCT02107170	Phase 4	Sevoflurane;Propofol;Remifentanil
11	Statin Use in Abdominal Aortic Aneurysm Repair	Completed	NCT01062802	Phase 4	Atorvastatin
12	Opioid-potentiated Volative Anaesthetic Vs. Remifentanil And Propofol During Abdominal Aortic Aneurysm Surgery	Completed	NCT00538421	Phase 4	Propofol;Sevoflurane
13	CUstodiol Versus RInger: whaT Is the Best Agent?	Completed	NCT02327611	Phase 4	Custodiol;Enriched Ringer's lactate solution
14	Prevalence of Abdominal Aortic Aneurysm in Patients Undergoing Coronary Angiography	Completed	NCT01239225	Phase 4
15	Epidural Versus Wound Infusion Plus Morphine Bolus in Open Abdominal Aortic Aneurysm Repair	Completed	NCT02677532	Phase 4	Paracetamol;Levobupivacaine wound infiltration;Levobupivacaine epidural bolus;Sufentanil epidural bolus;Morphine;Levobupivacaine plus sufentanil epidural infusion;Levobupivacaine wound infusion
16	Thoracoabdominal Arortic CTA Study	Completed	NCT02291718	Phase 4	Isovue
17	TAP-Block in Abdominal Aortic Surgery	Completed	NCT03657979	Phase 4	Ropivacaine;Placebo
18	Fibrinogen as an Alternative to FFP in Aortic Surgery.	Completed	NCT00994045	Phase 4
19	Vasculopathic Injury and Plasma as Endothelial Rescue - OCTAplas Trial (EudraCT no. 2014-000452-28)	Completed	NCT02253082	Phase 4	OctaplasLG®
20	Tranexamic Acid in Major Vascular Surgery	Completed	NCT02335359	Phase 4	tranexamic acid diluted in 100 ml of saline solution (loading dose);tranexamic acid undiluted (continous infusion);Placebo
21	Atorvastatin in Perioperative Vascular Surgery - Pilot Study	Completed	NCT00610545	Phase 4	Atorvastatin;Atorvastatin
22	A Controlled Trial of Effectiveness of a Backward Walking Program in Patients Recovering From Abdominal Aorta Surgery	Completed	NCT00819936	Phase 4
23	Study of Tomography of Nephrolithiasis Evaluation	Completed	NCT01451931	Phase 4
24	Randomized Trial of Pulsatile vs Non Pulsatile Perfusion on Short Term Changes in Kidney Function Using an Intra-Aortic Ballooon Pump During Cardioplegic Arrest in Patients Undergoing Myocardial Reperfusion	Completed	NCT00454428	Phase 4
25	OlmeSartan and Calcium Antagonists Randomized (OSCAR) Study	Completed	NCT00134160	Phase 4	Olmesartan medoxomil;Calcium channel blockers (amlodipine, azelnidipine)
26	Eplerenone in the Management of Abdominal Aortic Aneurysms	Recruiting	NCT02345590	Phase 4	Eplerenone
27	Predictors of AAA Expansion and/or Rupture	Recruiting	NCT03231397	Phase 4	Assess AAA rupture risk by PET-CTA scans;18F-fludeoxyglucose (FDG)
28	Randomized Preventive Vascular Screening Trial of 65-74 Year Old Men in the Central Region of Denmark	Recruiting	NCT00662480	Phase 4
29	Desflurane vs. Sevoflurane in Endovascular Aortic Repair	Recruiting	NCT03917186	Phase 4	Sevoflurane;Desflurane
30	Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Randomized Clinical Trial	Recruiting	NCT02678728	Phase 4	Dexmedetomidine;normal saline
31	Pilot Study of of Renal Arterial Sympathetic Denervation by Cryotherapy	Active, not recruiting	NCT02345603	Phase 4
32	Post-Market Study to Assess Outcomes of Patients Treated With AFX System Compared to Other EVAR Devices	Enrolling by invitation	NCT02407457	Phase 4
33	Comparison of Surveillance Versus Aortic Endografting for Small Aneurysm Repair	Terminated	NCT00118573	Phase 4
34	Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic Aneurysms	Terminated	NCT00409344	Phase 4	Dexmedetomidine
35	Long-term Benefit of Aortic Stent-graft in Patients With Distal Aortic Dissection	Terminated	NCT01354119	Phase 4
36	A Safety and Efficacy Study of Blood Pressure Control in Acute Aortic Emergencies - A Pilot Study (PROMPT)	Terminated	NCT01033370	Phase 4	clevidipine.
37	Bloodtranfusions After Aortic Surgery	Terminated	NCT02299947	Phase 4	Haemocomplettan P;Placebo
38	ATLANTIS:Extensive Type A Dissections and Thoracic/ Thoraco-Abdominal Aneurysms Repair With LupiAe Hybrid TechNique	Withdrawn	NCT01107366	Phase 4
39	NExT ERA: National Expertise Based Trial of Elective Repair of Abdominal Aortic Aneurysms: A Pilot Study	Unknown status	NCT00358085	Phase 3
40	34mm Cuff Study for Endovascular Repair of Abdominal Aortic Aneurysms	Unknown status	NCT00706394	Phase 2, Phase 3
41	Magnetic Resonance Imaging of Aortic Aneurysm Instability	Unknown status	NCT00794092	Phase 2, Phase 3	Sinerem administration
42	Efficacy of the Ultrasound-guided Transversus Abdominis Plane Block in Open Aortic Abdominal Aneurysm Repair Surgery	Unknown status	NCT02292667	Phase 3	PCA with Chlorhydrate of Morphine;Acetaminophen
43	Study of Aortic Root Reimplantation Procedure	Unknown status	NCT01787604	Phase 3
44	The Use of Nesiritide in Thoracic Aneurysm Repair to Prevent Acute Renal Failure	Unknown status	NCT00110201	Phase 3	Nesiritide
45	Clinical Evaluation of a Modular Extracorporeal Circulation Circuit	Unknown status	NCT02000544	Phase 3
46	Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) Trial of Cardiovascular Events in High-Risk Hypertensive Patients	Unknown status	NCT00125463	Phase 3	Candesartan cilexetil
47	Study of the Endovascular QUANTUM LP™ Stent Graft System in Abdominal Aortic Aneurysms (AAA)	Completed	NCT00233688	Phase 3
48	Curcumin to Prevent Complications After Elective Abdominal Aortic Aneurysm (AAA) Repair	Completed	NCT01225094	Phase 2, Phase 3	curcumin
49	Prevention of Colon Ischemia During Aortic Aneurysm (AAA) Repair	Completed	NCT00671203	Phase 3
50	ARBITER-II: Aorfix™ Bifurcated Safety and Performance Trial: Phase II, Angulated Vessels	Completed	NCT00442065	Phase 2, Phase 3

Search NIH Clinical Center for Aortic Aneurysm

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :

trimethaphan camsylate

Cochrane evidence based reviews: aortic aneurysm

Sources

Genetic Tests for Aortic Aneurysm

Genetic tests related to Aortic Aneurysm:

#	Genetic test	Affiliating Genes
1	Aortic Aneurysm ³⁰

Sources

Anatomical Context for Aortic Aneurysm

MalaCards organs/tissues related to Aortic Aneurysm:

⁴²

Kidney, Heart, Spinal Cord, Testes, Lung, Smooth Muscle, Endothelial

Sources

Publications for Aortic Aneurysm

Articles related to Aortic Aneurysm:

(show top 50) (show all 6757)

#	Title	Authors	Year
1	A Pilot Study of Protein Microarray for Simultaneous Analysis of 274 Cytokines Between Abdominal Aortic Aneurysm and Normal Aorta. ( 31018647 )	Yuwen L...Jie L	2019
2	microRNA expression profile in Smooth Muscle Cells isolated from thoracic aortic aneurysm samples. ( 31022558 )	Kasprzyk-Pawelec A...Kozar-Kaminska K	2019
3	Klf4, Klf2, and Zfp148 activate autophagy-related genes in smooth muscle cells during aortic aneurysm formation. ( 31025534 )	Salmon M...Ailawadi G	2019
4	The influence of statins on aortic aneurysm after operation: A retrospective nationwide study. ( 31027125 )	Liao KM...Huang YB	2019
5	DAB2IP Expression in Abdominal Aortic Aneurysm: EZH2 and mir-363-3p as Potential Mediators. ( 31028191 )	Legaki E...Gazouli M	2019
6	A Case of Myocardial Ischemia Detected by Global Longitudinal Strain Using Intraoperative Speckle-Tracking Echocardiography in a High-Risk Patient Undergoing Abdominal Aortic Aneurysm Repair. ( 31028240 )	Eisenberg S...Roberts SM	2019
7	Long term survival and cardiovascular morbidity after elective open aortic aneurysm repair in patients with and without type 2 diabetes: a nationwide propensity-adjusted analysis. ( 31029685 )	Zarrouk M...Gotts?ter A	2019
8	Abdominal aortic aneurysm as an IgG4-related disease. ( 31032886 )	Prucha M...Sedlackova L	2019
9	Efficacy of Unibody Bifurcated Endovascular Stent-Graft Repair in the Treatment of Abdominal Aortic Aneurysm. ( 31036115 )	Shi C...Chen Q	2019
10	Variation in the choice of elective surgical procedure for abdominal aortic aneurysm in Spain. ( 31040686 )	Quintana MJ...Bonfill X	2019
11	Numerical investigation of the effects of blood rheology and wall elasticity in abdominal aortic aneurysm under pulsatile flow conditions. ( 31045509 )	Bilgi C...Atal?k K	2019
12	Single-stage repair of thoracic aortic aneurysm and spinal cord compression. ( 31046395 )	Kumar A...Haridas AK	2019
13	Impaired smooth muscle cell contractility as a novel concept of abdominal aortic aneurysm pathophysiology. ( 31048749 )	Bogunovic N...Yeung KK	2019
14	Ventricular Dysfunction in a 40-Year-Old With Coronary Compression From Aortic Aneurysm Following Waterston Shunt and Complete Repair of Tetralogy of Fallot. ( 31049477 )	Wilhelm CM...Mah ML	2019
15	Intercostal artery stent grafting to prevent paraplegia during endovascular treatment of an intercostal loop graft aneurysm after thoracoabdominal aortic aneurysm repair. ( 31053441 )	Tjaden BL...Afifi RO	2019
16	ACR Appropriateness Criteria® Abdominal Aortic Aneurysm Follow-up (Without Repair). ( 31054747 )	Expert Panel on Vascular Imaging:...Dill KE	2019
17	Abdominal Aortic Aneurysm Repair Readmissions and Disparities of Socioeconomic Status: A Multistate Analysis, 2007-2014. ( 31064731 )	Perlstein MD...White RS	2019
18	Management of Chronic Disseminated Intravascular Coagulation Associated with Aortic Aneurysm/Dissection. ( 31065391 )	Koba S...Imashuku S	2019
19	Late renal artery stent fracture with pseudoaneurysm after fenestrated endovascular abdominal aortic aneurysm repair. ( 31065610 )	Yapa SM...Sieunarine K	2019
20	Ruptured abdominal aortic aneurysm mimicking acute coronary syndrome. ( 31066729 )	Sojka M...Jargie??o T	2019
21	Nationwide comparison of long-term survival and cardiovascular morbidity after acute aortic aneurysm repair in patients with and without type 2 diabetes. ( 31068268 )	Taimour S...Gotts?ter A	2019
22	Smooth muscle-specific Gsα deletion exaggerates angiotensin II-induced abdominal aortic aneurysm formation in mice in vivo. ( 31071332 )	Qin X...Zhang W	2019
23	Conformability and Efficacy of the Zenith Spiral Z Leg Compared with the Zenith Flex Leg in Endovascular Aortic Aneurysm Repair. ( 31071429 )	Iwakoshi S...Kichikawa K	2019
24	Prediction of Survival After 48 Hours of Intensive Unit Care Following Repair of Ruptured Abdominal Aortic Aneurysm - Multicentric Study for External Validation of a New Prediction Score for 30-Day Mortality. ( 31075455 )	Coelho A...Canedo A	2019
25	Design of The PReferences for Open Versus Endovascular Repair of Abdominal Aortic Aneurysm (PROVE-AAA) Trial. ( 31075459 )	Columbo JA...PROVE-AAA Study Team	2019
26	Large diameter (≥29 mm) proximal aortic necks are associated with increased complication rates after endovascular repair for abdominal aortic aneurysm. ( 31075483 )	Kouvelos G...Matsagkas M	2019
27	Early Outcomes after Thoracoabdominal Aortic Aneurysm Repair with Hypothermic Circulatory Arrest. ( 31085168 )	Kouchoukos NT...Castner CF	2019
28	Percutaneous closure of aorto-right atrial fistula after ascending aortic aneurysm surgery using cardiac fusion imaging. ( 31085501 )	Cruz-Gonz?lez I...Sanchez-Fernandez PL	2019
29	Ascending aortic aneurysm exposed to direct impingement of eccentric flow jets through a tilting-disc valve prosthesis. ( 31086647 )	Nagamine H...Kawase Y	2019
30	Image Fusion Guidance for In Situ Laser Fenestration of Aortic Stent graft for Endovascular Repair of Complex Aortic Aneurysm: Feasibility, Efficacy and Overall Functional Success. ( 31087148 )	Leger T...Kobeiter H	2019
31	A novel vision-based system for quantitative analysis of abdominal aortic aneurysm deformation. ( 31088563 )	Polanczyk A...Strzelecki M	2019
32	Infectious Aortitis with Abdominal Aortic Aneurysm in a 47-Year-Old Female with Systemic Lupus Erythematosus. ( 31089427 )	Ramiro VR...Abola MTB	2019
33	Fluoroquinolones And Associated Risk Of Aortic Aneurysm: An FDA Warning. ( 31094137 )	Baig U...Mehdi SM	2019
34	Expression levels of cathepsin L and cystatin C in a hyperglycemic environment were associated with aortic aneurysm development in a mouse model. ( 31096818 )	Liu Y...Jiang J	2019
35	Psychometric validation of three new condition-specific questionnaires to assess quality of life, symptoms and treatment satisfaction of patients with aortic aneurysm. ( 31098754 )	Romaine J...Bradley C	2019
36	Unusual Presentation of Ruptured Abdominal Aortic Aneurysm. ( 31104382 )	Moreira M...Gon?alves ?	2019
37	Estimation of Abdominal Aortic Aneurysm Rupture Risk with Biomechanical Imaging Markers. ( 31109852 )	Jalalzadeh H...Balm R	2019
38	Influence of earthquakes on the occurrence of aortic aneurysm ruptures. ( 31112028 )	De Donato G...Setacci C	2019
39	Predictors of in-hospital adverse events after endovascular aortic aneurysm repair. ( 30777687 )	Nejim B...Malas M	2019
40	Long-term outcome of sac filling with fibrin sealant after endovascular aneurysm repair of abdominal aortic aneurysm with challenging aortic neck anatomy. ( 30777688 )	Zhang L...Lu QS	2019
41	Greater Aortic Stiffness and Pulsatile Arterial Load Are Associated With Larger Thoracic Aortic Aneurysm Size in Women. ( 30779642 )	Jue J...Coutinho T	2019
42	Impending rupture of aortic aneurysm eroding skin and sternum: a rare condition. ( 30781972 )	Porapakkham P	2019
43	3D segmentation of exterior wall surface of abdominal aortic aneurysm from CT images using variable neighborhood search. ( 30782525 )	Siriapisith T...Haddawy P	2019
44	Systematic review of Quality of Life in persons with Hereditary Thoracic Aortic Aneurysm and Dissection diagnoses. ( 30788842 )	Velvin G...Geirdal A?	2019
45	Forecasting aortic aneurysm rupture: A systematic review of seasonal and atmospheric associations. ( 30792059 )	Choong AMTL...Walker PJ	2019
46	Transforming growth factor β neutralization finely tunes macrophage phenotype in elastase-induced abdominal aortic aneurysm and is associated with an increase of arginase 1 expression in the aorta. ( 30792060 )	Raffort J...Mallat Z	2019
47	A potential key mechanism in ascending aortic aneurysm development: Detection of a linear relationship between MMP-14/TIMP-2 ratio and active MMP-2. ( 30794673 )	Schmitt R...Kari FA	2019
48	Response to 'Re. Importance of Surgeon Experience in the Relationship between Abdominal Aortic Aneurysm Surgery Volume and Peri-operative Mortality'. ( 30795928 )	Varcoe RL...Verhoeven ELG	2019
49	The 2019 update of the European abdominal aortic aneurysm guidelines. ( 30798841 )	Dalman RL	2019
50	Regarding "Financial implications of coding inaccuracies in patients undergoing elective endovascular abdominal aortic aneurysm repair". ( 30798848 )	Mitchell E...Winterborn R	2019

Sources

Genes for Aortic Aneurysm

Genes related to Aortic Aneurysm (1 elite genes):

(show all 24)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	FBN1	Fibrillin 1	Protein Coding	446.15	Pathogenic/Likely pathogenic ⁶ DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Variants (show sections)	9260256
2	CDKN2B-AS1	CDKN2B Antisense RNA 1	RNA Gene	160.27	Experimental evidence: Expression ⁴⁰ DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)	19343170
3	HIF1A-AS1	HIF1A Antisense RNA 1	RNA Gene	154.8	Experimental evidence: Expression ⁴⁰ DISEASES inferred ¹⁵	24875884
4	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	57.3	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
5	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	56.96	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
6	MYH11	Myosin Heavy Chain 11	Protein Coding	47.12	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
7	MYLK	Myosin Light Chain Kinase	Protein Coding	46	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
8	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	45.98	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
9	SMAD3	SMAD Family Member 3	Protein Coding	45.65	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
10	LOX	Lysyl Oxidase	Protein Coding	43.34	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
11	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	42.08	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
12	MFAP5	Microfibril Associated Protein 5	Protein Coding	39.78	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
13	ELN	Elastin	Protein Coding	35.59	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
14	COL3A1	Collagen Type III Alpha 1 Chain	Protein Coding	33.39	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
15	PRKG1	Protein Kinase CGMP-Dependent 1	Protein Coding	33.08	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Variants (show sections)
16	EFEMP2	EGF Containing Fibulin Extracellular Matrix Protein 2	Protein Coding	32.89	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
17	SLC2A10	Solute Carrier Family 2 Member 10	Protein Coding	31.84	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
18	NOTCH1	Notch Receptor 1	Protein Coding	31.78	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
19	BGN	Biglycan	Protein Coding	31.49	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Variants (show sections)
20	FBN2	Fibrillin 2	Protein Coding	31.34	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
21	FBLN5	Fibulin 5	Protein Coding	30.57	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
22	MMP13	Matrix Metallopeptidase 13	Protein Coding	30.46	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Functions (show sections)
23	FLNA	Filamin A	Protein Coding	19.34	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
24	FOXE3	Forkhead Box E3	Protein Coding	17.6	GeneCards inferred via : Disorders Variants (show sections)

Sources

Variations for Aortic Aneurysm

ClinVar genetic disease variations for Aortic Aneurysm:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	COL3A1	NM_000090.3(COL3A1): c.505C> T (p.Leu169Phe)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs111391222	GRCh37	Chromosome 2, 189851842: 189851842
2	COL3A1	NM_000090.3(COL3A1): c.505C> T (p.Leu169Phe)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs111391222	GRCh38	Chromosome 2, 188987116: 188987116
3	MYH11	NM_001040113.1(MYH11): c.4963C> T (p.Arg1655Cys)	single nucleotide variant	Uncertain significance	rs369409348	GRCh37	Chromosome 16, 15814019: 15814019
4	MYH11	NM_001040113.1(MYH11): c.4963C> T (p.Arg1655Cys)	single nucleotide variant	Uncertain significance	rs369409348	GRCh38	Chromosome 16, 15720162: 15720162
5	FBN1	NM_000138.4(FBN1): c.7754T> C (p.Ile2585Thr)	single nucleotide variant	Pathogenic/Likely pathogenic	rs727503054	GRCh37	Chromosome 15, 48712949: 48712949
6	FBN1	NM_000138.4(FBN1): c.7754T> C (p.Ile2585Thr)	single nucleotide variant	Pathogenic/Likely pathogenic	rs727503054	GRCh38	Chromosome 15, 48420752: 48420752
7	TGFB2	NM_001135599.3(TGFB2): c.440C> T (p.Pro147Leu)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs149533093	GRCh37	Chromosome 1, 218578520: 218578520
8	TGFB2	NM_001135599.3(TGFB2): c.440C> T (p.Pro147Leu)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs149533093	GRCh38	Chromosome 1, 218405178: 218405178

Sources

Expression for Aortic Aneurysm

Search GEO for disease gene expression data for Aortic Aneurysm.

Sources

Pathways for Aortic Aneurysm

Pathways related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 45)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶⁵ Show member pathways ILK Signaling ⁶⁵ MAPK Signaling ⁶⁵ Molecular Mechanisms of Cancer ⁶⁵ Rho Family GTPases ⁶⁵	13.72	ACTA2 COL3A1 EFEMP2 ELN FBN1 FBN2
2	PAK Pathway ⁶⁵ Show member pathways Antioxidant Action of Vitamin-C ⁶⁵ Epithelial Adherens Junctions ⁶⁵	13.2	ACTA2 MYH11 MYLK NOTCH1 SLC2A10 SMAD3
3	Integrin Pathway ⁶⁵ Show member pathways FAK1 Signaling ⁶⁵ GnRH Signaling ⁶⁵ Inhibition of Angiogenesis by TSP1 ⁶⁵ Transendothelial Migration of Leukocytes ⁶⁵ UPA-UPAR Pathway ⁶⁵	13.14	ACTA2 COL3A1 EFEMP2 ELN FBN1 FBN2
4	Circadian entrainment ³⁸ Show member pathways Cholinergic synapse ³⁸ Dopaminergic synapse ³⁸ Estrogen signaling pathway ³⁸ Glutamatergic synapse ³⁸ Relaxin receptors ⁶⁷ Relaxin signaling pathway ³⁸ Synaptic Neurotransmission Pathways: Glutamatergic Excitation ⁶⁶	13.01	ACTA2 COL3A1 PRKG1 SMAD3 TGFBR1 TGFBR2
5	Phospholipase-C Pathway ⁶⁵ Show member pathways PTEN Pathway ⁶⁵	12.95	ACTA2 COL3A1 EFEMP2 ELN FBN1 FBN2
6	Sertoli-Sertoli Cell Junction Dynamics ⁶⁵ Show member pathways Epithelial Tight Junctions ⁶⁵ Germ Cell-Sertoli Cell Junction Dynamics ⁶⁵	12.87	ACTA2 MYH11 PRKG1 TGFB2 TGFBR1 TGFBR2
7	NFAT and Cardiac Hypertrophy ⁶⁵ Show member pathways IGF1R Signaling ⁶⁵ Signaling Involved in Cardiac Hypertrophy ⁶⁵	12.83	ACTA2 MYLK TGFB2 TGFBR1 TGFBR2
8	Pathways in cancer ³⁸	12.8	NOTCH1 SMAD3 TGFB2 TGFBR1 TGFBR2
9	Gastric cancer ³⁸ Show member pathways Breast cancer ³⁸ Hepatocellular carcinoma ³⁸	12.73	NOTCH1 SMAD3 TGFB2 TGFBR1 TGFBR2
10	Th17 cell differentiation ³⁸ Show member pathways IL-22 Pathway ⁶⁵ Immune response IL-22 signaling pathway ²³ Inflammatory bowel disease (IBD) ³⁸ Th1 and Th2 cell differentiation ³⁸	12.55	NOTCH1 SMAD3 TGFB2 TGFBR1 TGFBR2
11	Development EGFR signaling pathway ²³ Show member pathways Development ERBB-family signaling ²³ EGF Pathway ⁶⁵ EGFR Signaling Pathway ⁶⁸ ErbB receptor signaling network ¹	12.48	SMAD3 TGFB2 TGFBR1 TGFBR2
12	Degradation of the extracellular matrix ⁶⁷ Show member pathways Collagen degradation ⁶⁷ Extracellular matrix organization ⁶⁷	12.46	BGN COL3A1 EFEMP2 ELN FBN1 FBN2
13	Human Embryonic Stem Cell Pluripotency ⁶⁵ Show member pathways Factors Promoting Cardiogenesis in Vertebrates ⁶⁵	12.44	SMAD3 TGFB2 TGFBR1 TGFBR2
14	Human T-cell leukemia virus 1 infection ³⁸	12.32	SMAD3 TGFB2 TGFBR1 TGFBR2
15	Wnt / Hedgehog / Notch ⁴	12.22	NOTCH1 SMAD3 TGFB2 TGFBR1
16	Cell cycle Role of SCF complex in cell cycle regulation ²³ Show member pathways Cell cycle ESR1 regulation of G1/S transition ²³ Cell cycle Regulation of G1/S transition (part 1) ²³ Immune response MIF-JAB1 signaling ²³	12.2	SMAD3 TGFB2 TGFBR1 TGFBR2
17	Colorectal Cancer Metastasis ⁶⁵	12.16	SMAD3 TGFB2 TGFBR1 TGFBR2
18	Cellular senescence (KEGG) ³⁸	12.14	SMAD3 TGFB2 TGFBR1 TGFBR2
19	Hippo signaling pathway ³⁸	12.11	SMAD3 TGFB2 TGFBR1 TGFBR2
20	FoxO signaling pathway ³⁸ Show member pathways PLK2 and PLK4 events ¹ Polo-like kinase signaling events in the cell cycle ¹	12.05	SMAD3 TGFB2 TGFBR1 TGFBR2
21	Apelin signaling pathway ³⁸	12.04	ACTA2 MYLK SMAD3 TGFBR1
22	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins ²³ Show member pathways G-protein signaling G-Protein alpha-12 signaling pathway ²³	12.03	ACTA2 COL3A1 EFEMP2 ELN FBN1 FBN2
23	Th1 Differentiation Pathway ⁶⁶ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁶	12	SMAD3 TGFB2 TGFBR1 TGFBR2
24	SMAD Signaling Network ⁶⁵	12	ACTA2 SMAD3 TGFB2 TGFBR1 TGFBR2
25	TGF-beta Signaling Pathways ⁶⁶	11.84	SMAD3 TGFB2 TGFBR1 TGFBR2
26	Cytokine production by Th17 cells in CF (Mouse model) ²³ Show member pathways Cytokine production by Th17 cells in CF ²³	11.83	SMAD3 TGFBR1 TGFBR2
27	Angiogenesis (CST) ⁴	11.81	NOTCH1 TGFB2 TGFBR1
28	TGF-beta signaling pathway (KEGG) ³⁸	11.81	SMAD3 TGFB2 TGFBR1 TGFBR2
29	AGE-RAGE signaling pathway in diabetic complications ³⁸	11.8	COL3A1 SMAD3 TGFB2 TGFBR1 TGFBR2
30	Adherens junction ³⁸	11.71	SMAD3 TGFBR1 TGFBR2
31	Development_TGF-beta receptor signaling ²³	11.71	SMAD3 TGFBR1 TGFBR2
32	TGF-beta receptor signaling activates SMADs ⁶⁷ Show member pathways Downregulation of TGF-beta receptor signaling ⁶⁷ Signaling by TGF-beta Receptor Complex in Cancer ⁶⁷	11.69	SMAD3 TGFBR1 TGFBR2
33	Transcription_P53 signaling pathway ²³	11.64	ACTA2 SMAD3 TGFB2 TGFBR1 TGFBR2
34	TGF-beta Receptor Signaling (WikiPathways) ¹	11.6	SMAD3 TGFBR1 TGFBR2
35	IL-2 Gene Expression in Activated and Quiescent T-Cells ⁶⁵ Show member pathways TOB in T-Cell Signaling ⁶⁵	11.57	SMAD3 TGFB2 TGFBR1 TGFBR2
36	TGF-beta receptor signaling (Pathway Interaction Database) ¹	11.53	SMAD3 TGFBR1 TGFBR2
37	Cell adhesion_Plasmin signaling ²³	11.51	TGFB2 TGFBR1 TGFBR2
38	Microglia Activation During Neuroinflammation: Steady-State Microglia ⁶⁶	11.46	TGFB2 TGFBR1 TGFBR2
39	G-protein signaling_Cross-talk between Ras-family GTPases ²³	11.35	ACTA2 MYLK TGFB2 TGFBR1 TGFBR2
40	Smooth Muscle Contraction ⁶⁷	11.32	ACTA2 MYH11 MYLK
41	Extracellular vesicle-mediated signaling in recipient cells ¹	11.15	SMAD3 TGFB2 TGFBR1 TGFBR2
42	NTHi-Induced Signaling ⁶⁵	11.05	SMAD3 TGFBR1 TGFBR2
43	Elastic fibre formation ⁶⁷ Show member pathways Molecules associated with elastic fibres ⁶⁷	11.03	EFEMP2 ELN FBN1 FBN2 LOX MFAP5
44	G-protein signaling_Rap2B regulation pathway ²³	10.94	COL3A1 EFEMP2 ELN FBN1 FBN2 MYLK
45	Hypothesized Pathways in Pathogenesis of Cardiovascular Disease ¹	10.75	FBN1 FBN2 SMAD3 TGFBR1 TGFBR2

Sources

GO Terms for Aortic Aneurysm

Cellular components related to Aortic Aneurysm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.96	BGN COL3A1 EFEMP2 ELN FBN1 FBN2
2	receptor complex	GO:0043235	9.62	NOTCH1 SMAD3 TGFBR1 TGFBR2
3	extracellular matrix	GO:0031012	9.5	BGN COL3A1 ELN FBN1 FBN2 LOX
4	microfibril	GO:0001527	9.33	FBN1 FBN2 MFAP5
5	collagen-containing extracellular matrix	GO:0062023	9.17	BGN COL3A1 ELN FBN1 FBN2 MFAP5

Biological processes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 49)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell migration	GO:0030335	9.95	CDKN2B-AS1 MYLK NOTCH1 SMAD3 TGFBR1
2	in utero embryonic development	GO:0001701	9.94	NOTCH1 SMAD3 TGFBR1 TGFBR2
3	kidney development	GO:0001822	9.88	FBN1 TGFB2 TGFBR1
4	muscle contraction	GO:0006936	9.88	ACTA2 MYH11 MYLK
5	cell cycle arrest	GO:0007050	9.88	NOTCH1 SMAD3 TGFB2 TGFBR1
6	skeletal system development	GO:0001501	9.88	COL3A1 FBN1 SMAD3 TGFB2 TGFBR1
7	lung development	GO:0030324	9.86	LOX NOTCH1 TGFBR2
8	negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	9.83	SMAD3 TGFBR1 TGFBR2
9	cellular response to transforming growth factor beta stimulus	GO:0071560	9.81	FBN1 SMAD3 TGFBR1
10	heart looping	GO:0001947	9.8	NOTCH1 SMAD3 TGFBR2
11	embryonic limb morphogenesis	GO:0030326	9.8	FBN2 NOTCH1 TGFB2
12	extracellular matrix organization	GO:0030198	9.8	BGN COL3A1 ELN FBN1 FBN2 MFAP5
13	outflow tract morphogenesis	GO:0003151	9.79	ELN NOTCH1 TGFBR2
14	transforming growth factor beta receptor signaling pathway	GO:0007179	9.77	COL3A1 SMAD3 TGFB2 TGFBR1 TGFBR2
15	epithelial to mesenchymal transition	GO:0001837	9.74	NOTCH1 TGFB2 TGFBR1
16	embryonic cranial skeleton morphogenesis	GO:0048701	9.73	SMAD3 TGFBR1 TGFBR2
17	collagen fibril organization	GO:0030199	9.73	COL3A1 LOX TGFB2 TGFBR1
18	transmembrane receptor protein serine/threonine kinase signaling pathway	GO:0007178	9.71	TGFBR1 TGFBR2
19	ventricular trabecula myocardium morphogenesis	GO:0003222	9.71	NOTCH1 TGFB2 TGFBR1
20	ventricular septum morphogenesis	GO:0060412	9.71	NOTCH1 TGFB2 TGFBR1 TGFBR2
21	smooth muscle contraction	GO:0006939	9.7	MYH11 MYLK
22	activin receptor signaling pathway	GO:0032924	9.7	SMAD3 TGFBR1
23	cardiac epithelial to mesenchymal transition	GO:0060317	9.7	NOTCH1 TGFB2 TGFBR1
24	heart development	GO:0007507	9.7	COL3A1 FBN1 LOX NOTCH1 TGFB2 TGFBR1
25	endocardial cushion morphogenesis	GO:0003203	9.69	NOTCH1 TGFB2
26	regulation of epithelial cell proliferation	GO:0050678	9.69	NOTCH1 SMAD3
27	pathway-restricted SMAD protein phosphorylation	GO:0060389	9.69	TGFB2 TGFBR1 TGFBR2
28	cardiac muscle cell proliferation	GO:0060038	9.68	NOTCH1 TGFB2
29	negative regulation of immune response	GO:0050777	9.68	COL3A1 TGFB2
30	pulmonary valve morphogenesis	GO:0003184	9.68	NOTCH1 TGFB2
31	secondary palate development	GO:0062009	9.68	TGFB2 TGFBR2
32	supramolecular fiber organization	GO:0097435	9.67	COL3A1 MFAP5
33	cardiac left ventricle morphogenesis	GO:0003214	9.67	NOTCH1 TGFBR2
34	membranous septum morphogenesis	GO:0003149	9.67	TGFB2 TGFBR2
35	atrioventricular valve morphogenesis	GO:0003181	9.67	NOTCH1 TGFB2 TGFBR2
36	response to cholesterol	GO:0070723	9.66	TGFBR1 TGFBR2
37	somatic stem cell division	GO:0048103	9.66	NOTCH1 TGFB2
38	coronary artery morphogenesis	GO:0060982	9.65	NOTCH1 TGFBR1
39	embryonic eye morphogenesis	GO:0048048	9.65	FBN1 FBN2
40	elastic fiber assembly	GO:0048251	9.63	EFEMP2 LOX MYH11
41	aorta smooth muscle tissue morphogenesis	GO:0060414	9.61	COL3A1 MYLK
42	endocardial cushion fusion	GO:0003274	9.61	TGFB2 TGFBR2
43	glomerular mesangial cell development	GO:0072144	9.6	ACTA2 NOTCH1
44	regulation of transforming growth factor beta2 production	GO:0032909	9.59	SMAD3 TGFB2
45	sequestering of TGFbeta in extracellular matrix	GO:0035583	9.58	FBN1 FBN2
46	positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	GO:1905007	9.43	TGFB2 TGFBR1 TGFBR2
47	positive regulation of epithelial to mesenchymal transition	GO:0010718	9.35	NOTCH1 SMAD3 TGFB2 TGFBR1 TGFBR2
48	wound healing	GO:0042060	9.1	COL3A1 LOX SMAD3 TGFB2 TGFBR1 TGFBR2
49	positive regulation of gene expression	GO:0010628	10.04	ACTA2 CDKN2B-AS1 NOTCH1 SMAD3 TGFBR1

Molecular functions related to Aortic Aneurysm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	SMAD binding	GO:0046332	9.46	COL3A1 SMAD3 TGFBR1 TGFBR2
2	transforming growth factor beta-activated receptor activity	GO:0005024	9.37	TGFBR1 TGFBR2
3	transmembrane receptor protein serine/threonine kinase activity	GO:0004675	9.32	TGFBR1 TGFBR2
4	type II transforming growth factor beta receptor binding	GO:0005114	9.26	TGFB2 TGFBR1
5	extracellular matrix structural constituent	GO:0005201	9.17	BGN COL3A1 EFEMP2 ELN FBN1 FBN2
6	extracellular matrix constituent conferring elasticity	GO:0030023	9.13	ELN FBN1 FBN2

Sources

Sources for Aortic Aneurysm

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

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Aortic Aneurysm

Aliases & Classifications for Aortic Aneurysm

MalaCards integrated aliases for Aortic Aneurysm:

Classifications:

External Ids:

Summaries for Aortic Aneurysm

Related Diseases for Aortic Aneurysm

Diseases related to Aortic Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Aortic Aneurysm via Phenotypic Disease Network (PDN): (show all 15)

Graphical network of the top 20 diseases related to Aortic Aneurysm:

Symptoms & Phenotypes for Aortic Aneurysm

UMLS symptoms related to Aortic Aneurysm:

GenomeRNAi Phenotypes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Aortic Aneurysm:

Drugs & Therapeutics for Aortic Aneurysm

Drugs for Aortic Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 74 / NDF-RT 52 :

Cochrane evidence based reviews: aortic aneurysm

Genetic Tests for Aortic Aneurysm

Genetic tests related to Aortic Aneurysm:

Anatomical Context for Aortic Aneurysm

MalaCards organs/tissues related to Aortic Aneurysm:

Publications for Aortic Aneurysm

Articles related to Aortic Aneurysm:

Genes for Aortic Aneurysm

Genes related to Aortic Aneurysm (1 elite genes):

Variations for Aortic Aneurysm

ClinVar genetic disease variations for Aortic Aneurysm:

Expression for Aortic Aneurysm

Pathways for Aortic Aneurysm

Pathways related to Aortic Aneurysm according to GeneCards Suite gene sharing:

GO Terms for Aortic Aneurysm

Cellular components related to Aortic Aneurysm according to GeneCards Suite gene sharing:

Biological processes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

Molecular functions related to Aortic Aneurysm according to GeneCards Suite gene sharing:

Sources for Aortic Aneurysm

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :