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MCID: ART016
MIFTS: 68

Aortic Aneurysm

Categories: Blood diseases, Cardiovascular diseases
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Aliases & Classifications for Aortic Aneurysm

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MalaCards integrated aliases for Aortic Aneurysm:

Name: Aortic Aneurysm 11 75 28 5 41 2 43 14 16 71
Aortic Rupture 43 16 71
Thoracoabdominal Aortic Aneurysm, Ruptured 71 31
Aortic Aneurysm Without Mention of Rupture Nos 71
Ruptured Abdominal Aortic Aneurysm 71
Ruptured Thoracic Aortic Aneurysm 71
Aortic Aneurysm, Ruptured 71
Ruptured Aortic Aneurysm 11
Aortic Aneurysms 14

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 31


External Ids:

Disease Ontology 11 DOID:3627
UMLS 71 C0003486 C0003496 C0265010 more
Sources

Summaries for Aortic Aneurysm

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MedlinePlus: 41 An aneurysm is a bulge or "ballooning" in the wall of an artery. Arteries are blood vessels that carry oxygen-rich blood from the heart to other parts of the body. If an aneurysm grows large, it can burst and cause dangerous bleeding or even death. Most aneurysms are in the aorta, the main artery that runs from the heart through the chest and abdomen. There are two types of aortic aneurysm: Thoracic aortic aneurysms (TAA) - these occur in the part of the aorta running through the chest Abdominal aortic aneurysms (AAA) - these occur in the part of the aorta running through the abdomen Most aneurysms are found during tests done for other reasons. Some people are at high risk for aneurysms. It is important for them to get screening, because aneurysms can develop and become large before causing any symptoms. Screening is recommended for people between the ages of 65 and 75 if they have a family history, or if they are men who have smoked. Doctors use imaging tests to find aneurysms. Medicines and surgery are the two main treatments. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary: Aortic Aneurysm, also known as aortic rupture, is related to aortic aneurysm, familial abdominal, 1 and loeys-dietz syndrome 1, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Aortic Aneurysm is FBN1 (Fibrillin 1), and among its related pathways/superpathways are ERK Signaling and PAK Pathway. The drugs Eplerenone and Acetazolamide have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and spinal cord, and related phenotypes are muscle and growth/size/body region

CDC: 2 An aortic aneurysm is a balloon-like bulge in the aorta, the large artery that carries blood from the heart through the chest and torso. Aortic aneurysms work in two ways: • The force of blood pumping can split the layers of the artery wall, allowing blood to leak in between them. This process is called a dissection. • The aneurysm can burst completely, causing bleeding inside the body. This is called a rupture. • Dissections and ruptures are the cause of most deaths from aortic aneurysms.

Disease Ontology: 11 An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size.

Wikipedia: 75 An aortic aneurysm is an enlargement (dilatation) of the aorta to greater than 1.5 times normal size.... more...
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Related Diseases for Aortic Aneurysm

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Diseases related to Aortic Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1196)
# Related Disease Score Top Affiliating Genes
1 aortic aneurysm, familial abdominal, 1 33.6 TGFBR2 MYH11 MMP13 LOX FBN1 ELN
2 loeys-dietz syndrome 1 33.3 TGFBR2 TGFBR1 TGFB2 SMAD3 FBN1
3 aortic aneurysm, familial thoracic 4 33.3 TGFBR2 TGFBR1 TGFB2 SMAD3 MYH11 FBN1
4 loeys-dietz syndrome 2 33.1 TGFBR2 TGFBR1 TGFB2 SMAD3 FBN1
5 aortic aneurysm, familial thoracic 1 32.9 TGFBR2 TGFBR1 TGFB2 SMAD3 ROBO4 MYLK
6 marfan syndrome 32.7 TGFBR2 TGFBR1 TGFB2 LOX FBN1 ELN
7 loeys-dietz syndrome 32.6 TGFBR2 TGFBR1 TGFB2 SMAD3 MYLK MYH11
8 cutis laxa, autosomal dominant 1 32.4 TGFBR2 TGFBR1 FBN1 FBLN5 ELN EFEMP2
9 loeys-dietz syndrome 5 32.3 TGFBR2 TGFBR1 TGFB2 SMAD3 FBN1
10 cutis laxa, autosomal recessive, type ib 32.3 FBLN5 ELN EFEMP2
11 loeys-dietz syndrome 4 32.3 TGFBR2 TGFBR1 TGFB2 SMAD3 MYH11 FBN1
12 aortic valve disease 1 32.2 TGFBR2 TGFBR1 TGFB2 SMAD3 ROBO4 MYLK
13 cutis laxa, autosomal dominant 2 32.2 FBLN5 EFEMP2
14 loeys-dietz syndrome 3 32.2 TGFBR2 TGFBR1 TGFB2 SMAD3 MYLK MYH11
15 aortic dissection 32.0 TGFBR1 TGFB2 SMAD3 MYH11 MFAP5 LOX
16 aortic valve insufficiency 31.9 TGFBR2 TGFBR1 MYH11 FBN1 ELN EFEMP2
17 aortic disease 31.8 TGFBR2 TGFBR1 TGFB2 SMAD3 MYH11 FBN1
18 aortitis 31.6 FBN1 ELN
19 lipoprotein quantitative trait locus 31.6 TGFBR2 TGFB2 SMAD3 MYH11 FBN1 ELN
20 connective tissue disease 31.5 TGFBR2 SMAD3 MMP13 LOX FBN1 FBLN5
21 inguinal hernia 31.3 TGFBR2 TGFBR1 MMP13 FBN1 FBLN5 ELN
22 mitral valve insufficiency 31.3 MYH11 FBN1 ELN
23 patent ductus arteriosus 1 31.1 TGFBR2 TGFBR1 TGFB2 SMAD3 MYLK MYH11
24 ehlers-danlos syndrome, vascular type 31.0 MYLK MYH11 FBN1 FBLN5 ELN EFEMP2
25 ehlers-danlos syndrome 31.0 TGFBR2 TGFBR1 TGFB2 SMAD3 MYLK MYH11
26 cutis laxa 30.9 LOX FBN1 FBLN5 ELN EFEMP2
27 scoliosis 30.9 TGFBR2 TGFB2 MMP13 LOX FBN1 FBLN5
28 pneumothorax 30.9 FBN1 FBLN5 ELN
29 contractural arachnodactyly, congenital 30.9 TGFBR2 TGFBR1 MFAP5 FBN1 ELN
30 dilated cardiomyopathy 30.8 SMAD3 MYLK MYH11 FBN1 ELN ACTA2
31 collagen disease 30.8 TGFBR2 TGFBR1 FBN1 ELN ACTA2
32 pulmonary hypertension 30.8 TGFBR2 TGFBR1 SMAD3 ELN ACTA2
33 arterial tortuosity syndrome 30.8 TGFBR2 TGFBR1 TGFB2 SMAD3 MYLK MYH11
34 supravalvular aortic stenosis 30.7 MYH11 FBN1 FBLN5 ELN EFEMP2 ACTA2
35 telangiectasis 30.7 TGFBR1 FBN1 ELN
36 hereditary hemorrhagic telangiectasia 30.7 TGFBR2 TGFBR1 TGFB2 SMAD3
37 craniosynostosis 30.6 TGFBR2 TGFBR1 SMAD3 FBN1
38 mitral valve disease 30.6 TGFBR2 TGFBR1 TGFB2 FBN1 ELN
39 moyamoya disease 1 30.6 MYLK MYH11 ELN ACTA2
40 orthostatic intolerance 30.5 TGFBR2 TGFBR1 TGFB2 SMAD3 MYH11 FBN1
41 exfoliation syndrome 30.5 LOX FBN1 ELN
42 atrial heart septal defect 30.5 MYH11 FBN1 ELN
43 diaphragmatic hernia, congenital 30.5 ROBO4 FBN1 ELN EFEMP2
44 brittle bone disorder 30.5 MMP13 LOX FBN1 ELN
45 microcolon 30.4 MYLK MYH11
46 tricuspid valve prolapse 30.4 TGFBR2 TGFBR1 FBN1 EFEMP2
47 megacystis-microcolon-intestinal hypoperistalsis syndrome 1 30.3 MYLK MYH11 ACTA2
48 visceral myopathy 1 30.3 MYLK MYH11
49 bladder diverticulum 30.3 LOX FBLN5 ELN EFEMP2
50 occipital horn syndrome 30.3 LOX FBLN5 ELN EFEMP2

Comorbidity relations with Aortic Aneurysm via Phenotypic Disease Network (PDN): (show all 13)


Acute Cystitis Acute Kidney Failure
Acute Vascular Insufficiency of Intestine Aortic Valve Disease 1
Cardiac Arrest Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Paralytic Ileus Peripheral Vascular Disease
Respiratory Failure

Graphical network of the top 20 diseases related to Aortic Aneurysm:



Diseases related to Aortic Aneurysm
Sources

Symptoms & Phenotypes for Aortic Aneurysm

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UMLS symptoms related to Aortic Aneurysm:


angina pectoris; chest pain; edema

MGI Mouse Phenotypes related to Aortic Aneurysm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 10.22 ACTA2 EFEMP2 ELN FBLN5 FBN1 KLF15
2 growth/size/body region MP:0005378 10.18 EFEMP2 FBLN5 FBN1 KLF15 LOX MMP13
3 cardiovascular system MP:0005385 10.16 ACTA2 EFEMP2 ELN FBLN5 FBN1 KLF15
4 renal/urinary system MP:0005367 10.03 FBN1 KLF15 LOX MYH11 MYLK SMAD3
5 craniofacial MP:0005382 9.87 FBLN5 FBN1 LOX SMAD3 TGFB2 TGFBR1
6 respiratory system MP:0005388 9.85 EFEMP2 ELN FBLN5 FBN1 LOX MYH11
7 skeleton MP:0005390 9.7 EFEMP2 ELN FBN1 LOX MFAP5 MMP13
8 integument MP:0010771 9.32 EFEMP2 FBLN5 FBN1 LOX MMP13 MYH11
Sources

Drugs & Therapeutics for Aortic Aneurysm

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Drugs for Aortic Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 219)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Eplerenone Approved Phase 4 107724-20-9 443872
2
Acetazolamide Approved, Vet_approved Phase 4 59-66-5, 1424-27-7 1986
3
Iodine Approved, Investigational Phase 4 7553-56-2 807
4
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
5
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
6
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
7
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
8
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
9
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
10
Prednisolone Approved, Vet_approved Phase 4 50-24-8 4894 5755
11
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5 1875
12
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 4159 6741
13
Sorbitol Approved, Investigational Phase 4 69-65-8, 50-70-4 453 6251 5780
14
Atorvastatin Approved Phase 4 134523-00-5 60823
15
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
16
Heparin, bovine Approved, Investigational, Withdrawn Phase 4 9005-49-6 22833565 9812414 772
17
Ketamine Approved, Vet_approved Phase 4 6740-88-1, 1867-66-9 3821
18
Remifentanil Approved Phase 4 132875-61-7 60815
19
Cisatracurium Approved, Investigational Phase 4 96946-41-7 62887
20
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
21
Magnesium sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9
22
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3 3680
23
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 3003 5743
24
Tramadol Approved, Investigational Phase 4 27203-92-5 33741 5523
25
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
26
Ondansetron Approved, Withdrawn Phase 4 99614-02-5 4595
27
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
28
Desflurane Approved Phase 4 57041-67-5 42113
29
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
30
Clonidine Approved Phase 4 4205-91-8, 4205-90-7 2803 20179
31
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
32
Scopolamine Approved, Investigational Phase 4 51-34-3 153311 3000322
33
Morphine Approved, Investigational Phase 4 57-27-2 5288826
34
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
35
Metamizole Approved, Investigational, Withdrawn Phase 4 50567-35-6 3111 522325
36
Dexmedetomidine Approved, Experimental, Vet_approved Phase 4 86347-14-0, 113775-47-6 68602 5311068
37
Clevidipine Approved, Investigational Phase 4 167221-71-8 153994
38
Tryptophan Approved, Nutraceutical, Withdrawn Phase 4 73-22-3 6305
39
Cadexomer iodine Experimental Phase 4 94820-09-4
40
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7 4897
41 Hormone Antagonists Phase 4
42 diuretics Phase 4
43 Mineralocorticoids Phase 4
44 Mineralocorticoid Receptor Antagonists Phase 4
45 Carbonic Anhydrase Inhibitors Phase 4
46 Anticonvulsants Phase 4
47 Platelet Aggregation Inhibitors Phase 4
48 Anesthetics, Intravenous Phase 4
49 Anesthetics, General Phase 4
50 Anesthetics, Inhalation Phase 4

Interventional clinical trials:

(show top 50) (show all 673)
# Name Status NCT ID Phase Drugs
1 Eplerenone in the Management of Abdominal Aortic Aneurysms: A Proof-Of-Concept Randomised Controlled Trial Unknown status NCT02345590 Phase 4 Eplerenone
2 The Effect of Immunonutrition on Outcome and Postoperative Recovery in Patients Undergoing Elective Surgical Repair of a Thoraco (Abdominal) Aneurysm Aorta Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
3 Prophylactic Mesh Implantation After Abdominal Aortic Aneurysm Repair. A Prospective, Randomised, Controlled Study Unknown status NCT01353443 Phase 4
4 Fast-track in Endovascular Aortic Aneurysm Repair With Desflurane and Sevoflurane: a Randomized Clinical Trial Unknown status NCT03917186 Phase 4 Sevoflurane;Desflurane
5 Pilot Study of of Renal Arterial Sympathetic Denervation by Cryotherapy During Open Surgery for Aortic Aneurysm Unknown status NCT02345603 Phase 4
6 A Randomised Controlled Trial of the Effectiveness of Acetazolamide in Reducing Cerebrospinal Fluid Pressure for Patients Undergoing Thoracic-abdominal Aortic Repair Unknown status NCT01889498 Phase 4 Acetazolamide
7 Comparison of High Iodine Concentration Contrast Material (Isovue 370) vs Standard Protocol (Isovue 300) in Thoracoabdominal Aortic Computed Tomographic Angiography (CTA) for Radiation Dose Reduction Completed NCT02291718 Phase 4 Isovue
8 Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial) Completed NCT01904981 Phase 4 Beta-blocker-Atenolol 50mg, PO(peroral), Once daily;Angiotensin receptor blocker-Valsartan 80mg, PO(peroral), Once daily
9 TALENT Endoluminal Stent Graft System for the Treatment of Abdominal Aortic Aneurysms Completed NCT00803075 Phase 4
10 Endovascular Treatment of Thoracic Aortic Aneurysms Using the TALENT Stent Graft System Completed NCT00802984 Phase 4
11 Opioid-potentiated Volative Anaesthetic(Sevoflurane)Compared to Remifentanil and Propofol During Abdominal Aortic Aneurysm Surgery Completed NCT00538421 Phase 4 Propofol;Sevoflurane
12 Effects of OctaplasLG® on Endothelial Integrity in Patients Undergoing Emergency Surgery for Thoracic Aortic Dissections - a Randomized, Controlled, Single-blinded Investigator-initiated Pilot Trial Completed NCT02253082 Phase 4 OctaplasLG®
13 Study of the Effectiveness of Telmisartan in Slowing the Progression of Abdominal Aortic Aneurysms Completed NCT01683084 Phase 4 Telmisartan;Placebo
14 A Clinical Evaluation of the GORE EXCLUDER® Bifurcated Endoprosthesis - Low Permeability in the Primary Treatment of Infrarenal Abdominal Aortic Aneurysms Completed NCT00593814 Phase 4
15 CSP #498 - Open Versus Endovascular Repair (OVER) Trial for Abdominal Aortic Aneurysms Completed NCT00094575 Phase 4
16 CUstodiol Versus RInger: whaT Is the Best Agent? A Randomized Double Blind Trial. Completed NCT02327611 Phase 4 Custodiol;Enriched Ringer's lactate solution
17 Randomised Controlled Trial of Effect of Pre-operative Statin Use on Matrix Metalloproteinases (MMP) & Tissue Inhibitors of Matrix Metalloproteinases (TIMP) in Abdominal Aortic Aneurysm (AAA). Completed NCT01062802 Phase 4 Atorvastatin
18 Transversus Abdominis Plane (TAP) Block in Open Abdominal Aortic Surgery : Randomized Controlled Doubled-blind Trial Comparing Ropivacaine 0.2% Versus Placebo Completed NCT03657979 Phase 4 Ropivacaine;Placebo
19 Comparison of Intravenous Anesthetics and Volatile Anesthetics on Postoperative Cognitive Dysfunction of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities. Completed NCT02107170 Phase 4 Sevoflurane;Propofol;Remifentanil
20 Prevalence of Abdominal Aortic Aneurysm in Patients Undergoing Coronary Angiography Completed NCT01239225 Phase 4
21 Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Randomized Clinical Trial Completed NCT02678728 Phase 4 Dexmedetomidine;normal saline
22 Coagulopathy During Surgery for the Repair of Extent 4 Thoraco-Abdominal Aortic Aneurysms - Feasibility Study of the Use of Fibrinogen Concentrate by Infusion in Place of Fresh Frozen Plasma. Completed NCT00994045 Phase 4
23 Randomized Preventive Vascular Screening Trial of 65-74 Year Old Men in the Central Region of Denmark Recruiting NCT00662480 Phase 4
24 A Phase IV Double-blind, Randomised, Parallel Group Comparison of the Efficacy and Safety of Preoperative Intravenous Ferric Carboxymaltose and Placebo in the Treatment of Patients Undergoing Elective or Urgent Cardiac Surgery Recruiting NCT03574311 Phase 4 Ferric carboxymaltose
25 Effect of a Perioperative Opioid Free Anesthesia-Analgesia (OFA-A) Strategy on Surgical Stress Response in Elective Open Abdominal Aortic Aneurysm Repair: A Prospective Randomized Study Recruiting NCT04894864 Phase 4 Opioid-Based Anesthesia-Analgesia Strategy;Opioid-free Anesthesia-Analgesia Strategy
26 ACTION-1: ACT Guided Heparinization During Open Abdominal Aortic Aneurysm Repair, a Randomised Trial. Recruiting NCT04061798 Phase 4 ACT guided heparinization;5 000 IU of heparin
27 Physician Initiated Trial Investigating ESAR (EVAR Plus Heli-FX EndoAnchors) and FEVAR for the Treatment of Aortic Aneurysms With Short Infrarenal Aortic Neck Recruiting NCT04503395 Phase 4
28 Randomized, Double-blind, Placebo-controlled Single-centre Clinical Trial Evaluating Efficacy and Safety of Intraoperative and Postoperative Continuous Lidocaine Infusion in High Cardiac Risk Vascular Surgery Suspended NCT04691726 Phase 4 lidocaine 10mg/ml;Placebo;Metamizole;Morphine
29 Phase 4 Study of Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic Aneurysms Terminated NCT00409344 Phase 4 Dexmedetomidine
30 Randomized Clinical Trial Comparing Surveillance and Selective Surgical Treatment for Abdominal Aortic Aneurysms Less Than 5.5 cm in Diameter Versus Early Endovascular Treatment Terminated NCT00118573 Phase 4
31 Noninvasive Assessment of Abdominal Aortic Aneurysm (AAA) Wall Structural Integrity and Inflammation as Predictors of Expansion and/or Rupture Terminated NCT03231397 Phase 4 Assess AAA rupture risk by PET-CTA scans;18F-fludeoxyglucose (FDG)
32 A Safety and Efficacy Study of Blood Pressure Control in Acute Aortic Emergencies - A Pilot Study (PROMPT) Terminated NCT01033370 Phase 4 clevidipine.
33 Long-term Benefit of Aortic Stent-graft in Patients With Distal Aortic Dissection Terminated NCT01354119 Phase 4
34 Comparison of a Single Dose Fibrinogen With Placebo and the Number of Blood Transfusions After Ascending Aorta Surgery (FIBTEG Study) Terminated NCT02299947 Phase 4 Haemocomplettan P;Placebo
35 Extensive Type A Dissections and Thoracic/ Thoraco-Abdominal Withdrawn NCT01107366 Phase 4
36 Efficacy of the Ultrasound-guidedTransversus Abdominis Plane (TAP) Block on Postoperative Pain Control in Open Aortic Abdominal Aneurysm Repair Surgery Unknown status NCT02292667 Phase 3 PCA with Chlorhydrate of Morphine;Acetaminophen
37 Expertise Based Randomized Controlled Trial of Open Versus Endovascular Repair of Abdominal Aortic Aneurysms: A Pilot Study Unknown status NCT00358085 Phase 3
38 Prophylactic Use of Nesiritide (Brain Natriuretic Peptide, BNP) for the Prevention of Acute Renal Failure in Thoracic Aortic Aneurysm Surgery Patients Unknown status NCT00110201 Phase 3 Nesiritide
39 The Hemostatic Potential of TDM-621 on Ascending Aortic Surgery Unknown status NCT03917862 Phase 2, Phase 3
40 A Clinical Study of the TAG Thoracic Endoprosthesis in the Treatment of Thoracic Aortic Diseases for Non-Surgical Candidates Under the Physician Sponsored IDE. Completed NCT00757003 Phase 3
41 The Effect of Tranexamic Acid in Ruptured Abdominal Aortic Aneurysms Completed NCT02125890 Phase 3 Tranexamic Acid
42 A Study to Assess the Acute Technical Success of Aorfix™ Stent Grafts in the Treatment of Abdominal Aortic and Aorto-Iliac Aneurysm Where a Significant Degree of Vessel Angulation Exists at the Neck of the Aneurysm Completed NCT00442065 Phase 2, Phase 3
43 Evaluation of the Medtronic Vascular Talent Thoracic Stent Graft System for the Treatment of Thoracic Aortic Aneurysms Completed NCT00604799 Phase 2, Phase 3
44 A Prospective, Multicenter Study of the Cordis Endovascular QUANTUM LP™ Stent Graft System for the Treatment of Abdominal Aortic Aneurysms (AAA)-FORTRON Completed NCT00233688 Phase 3
45 Curcumin to Prevent Perioperative Complications After Elective Abdominal Aortic Aneurysm Repair: a Randomized Controlled Trial Completed NCT01225094 Phase 2, Phase 3 curcumin
46 Prevention of Colon Ischemia During Aortic Aneurysm (AAA) Repair Completed NCT00671203 Phase 3
47 Magnetic Resonance Imaging of Aortic Aneurysm Instability Completed NCT00794092 Phase 2, Phase 3 Sinerem administration
48 Conservative Aortic Valve Surgery for Aortic Insufficiency and Aneurysms of the Aortic Root Completed NCT00478803 Phase 3
49 Melatonin and Cardiac Morbidity After Elective Abdominal Aortic Aneurism Repair Completed NCT00315926 Phase 2, Phase 3 Melatonin;Placebo
50 Multicenter Randomized Controlled Trial of Loading Dose Statins for the Prevention of Cardiovascular Complications in High-Risk Non-Cardiac Surgery Completed NCT01543555 Phase 3 Atorvastatin;Placebo

Search NIH Clinical Center for Aortic Aneurysm

Inferred drug relations via UMLS 71 / NDF-RT 50 :


trimethaphan camsylate

Cochrane evidence based reviews: aortic aneurysm

Sources

Genetic Tests for Aortic Aneurysm

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Genetic tests related to Aortic Aneurysm:

# Genetic test Affiliating Genes
1 Aortic Aneurysm 28
Sources

Anatomical Context for Aortic Aneurysm

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Organs/tissues related to Aortic Aneurysm:

MalaCards : Heart, Lung, Spinal Cord, Smooth Muscle, Kidney, Endothelial, Brain
Sources

Publications for Aortic Aneurysm

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Articles related to Aortic Aneurysm:

(show top 50) (show all 36333)
# Title Authors PMID Year
1
Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms. 62 5
29689197 2018
2
Sinus of Valsalva Aneurysm in Females. 62 41
36372407 2022
3
Targeting autophagy in aortic aneurysm and dissection. 62 41
36076620 2022
4
Temperature effects on incidence of surgery for acute type A aortic dissection in the Nordics. 41
36345977 2022
5
Renovascular hypertension in Marfan syndrome. 53 62
9260256 1997
6
Low expression of ESR1 correlates with ascending aortic dilation and acute type A aortic dissection. 62
36279950 2023
7
HIV-associated infective native aortic aneurysms. 62
36106509 2023
8
A case of mediastinal abscess and infected aortic aneurysm caused by dissemination of Mycobacterium abscessus subsp. massiliense pulmonary disease. 62
36162647 2023
9
Successful Management of Prolonged Thrombocytopenia After Surgery for Abdominal Aortic Aneurysm With Disseminated Intravascular Coagulation. 62
36151060 2023
10
Spatiotemporal Registration of 3-D Multi-perspective Ultrasound Images of Abdominal Aortic Aneurysms. 62
36441033 2023
11
A role of FDG PET/CT for Response Assessment in Large Vessel Disease? 62
36075772 2023
12
Abdominal Aortic Aneurysms (Etiology, Epidemiology, and Natural History). 62
36328621 2022
13
Infectious Aortic Aneurysm in a Patient With Leriche Syndrome. 62
35714371 2022
14
Decreasing trends in reintervention and readmission after endovascular aneurysm repair in a multiregional implant registry. 62
35709865 2022
15
Self-reported symptoms of sleep-disordered breathing and risk of cardiovascular diseases: Observational and Mendelian randomization findings. 62
35869582 2022
16
Center volume and failure to rescue after open or endovascular repair of ruptured abdominal aortic aneurysms. 62
35872329 2022
17
Factors associated with preference of choice of aortic aneurysm repair in the PReference for Open Versus Endovascular repair of AAA (PROVE-AAA) study. 62
35863555 2022
18
Prediction of wall stress and oxygen flow in patient-specific abdominal aortic aneurysms: the role of intraluminal thrombus. 62
35908098 2022
19
Correction to: MiR‑30c‑1‑3p targets matrix metalloproteinase 9 involved in the rupture of abdominal aortic aneurysms. 62
36280603 2022
20
Endovascular Repair of Abdominal Aortic Aneurysms is a Valid Alternative to Open Repair also in Patients Treated Outside of Instructions for Use Criteria. 62
36333423 2022
21
Linking single nucleotide polymorphisms to signaling blueprints in abdominal aortic aneurysms. 62
36470918 2022
22
Please, Look Beyond. Comment on ''Chimney Versus Fenestrated Endovascular Versus Open Repair for Juxta/Pararenal Abdominal Aortic Aneurysms: Systematic Review and Network Meta-Analysis of the Short-Term Results''. 62
36474121 2022
23
Anesthetic Management for Endovascular Repair of Thoracic and Abdominal Aortic Aneurysms. 62
36328625 2022
24
Association Between Psoas Muscle Sarcopenia and Long-Term Survival Following Elective Endovascular Aortic Repair. 62
36058011 2022
25
Robotic-assisted abdominal aortic surgery: evidence and techniques. 62
35244871 2022
26
Primary care physicians' awareness and perceptions on adherence to primary cardiovascular disease prevention guidelines in Lebanon: A cross-sectional study. 62
33375844 2022
27
Gut Microbiota Influence the Development of Abdominal Aortic Aneurysm by Suppressing Macrophage Accumulation in Mice. 62
36252141 2022
28
Impact of interfacility transfer of ruptured abdominal aortic aneurysm patients. 62
35752382 2022
29
Overexpressed DDX3x promotes abdominal aortic aneurysm formation and activates AKT in ApoE knockout mice. 62
36242920 2022
30
Anesthetic Management for Open Thoracoabdominal and Abdominal Aortic Aneurysm Repair. 62
36328624 2022
31
Long-term outcome and cancer incidence after abdominal aortic aneurysm repair. 62
36094764 2022
32
Combined Open Repair of an Abdominal Aortic Aneurysm and Relief of a Left Ventricular Assist Device Outflow Graft Obstruction. 62
36123264 2022
33
CtBP proteins transactivate matrix metalloproteinases and proinflammatory cytokines to mediate the pathogenesis of abdominal aortic aneurysm. 62
36244410 2022
34
Characterization of immediate and early mortality after repair of ruptured abdominal aortic aneurysm. 62
35803483 2022
35
Female sex is associated with reintervention and mortality following elective endovascular abdominal aortic aneurysm repair. 62
35705120 2022
36
HPMC improves protective effects of naringenin and isonicotinamide co-crystals against abdominal aortic aneurysm. 62
34491473 2022
37
Association of Premature Menopause With Risk of Abdominal Aortic Aneurysm in the Women's Health Initiative. 62
33156064 2022
38
Calcitriol Supplementation Protects Against Apoptosis and Alleviates the Severity of Abdominal Aortic Aneurysm Induced by Angiotensin II and Anti-TGFβ. 62
35445935 2022
39
Arterial Evaluation. 62
36404060 2022
40
Surgical Correction of Ascending Aortic Aneurysm Without Coronary Dilatation After Kawasaki Disease in a 3-Year-Old Child. 62
34673520 2022
41
A huge ascending aortic aneurysm in a 2-year boy with Loeys-Dietz syndrome. 62
36464235 2022
42
Adventitia-derived extracellular matrix hydrogel enhances contractility of human vasa vasorum-derived pericytes via α2 β1 integrin and TGFβ receptor. 62
35770946 2022
43
13-year single-center experience with the treatment of acute type B aortic dissection. 62
36184791 2022
44
Fluoroquinolones and the risk of aortic aneurysm or aortic dissection: an updated systematic review and meta-analysis including 53,651,283 patients. 62
36468763 2022
45
Rare case of infective aortitis with aortic rupture and cardiac tamponade in a young child. 62
36455981 2022
46
Updates in aortic wall pathology. 62
34845508 2022
47
Successful Sac Embolization to Eliminate a Type 2 Endoleak After Thoracic Endovascular Aortic Repair by Penetration of a Vascular Plug Implanted in a Left Subclavian Artery. 62
34969293 2022
48
Generation of a human TGFB3-hIPSC line, BBANTWi010-A, from a Loeys-Dietz syndrome type V patient. 62
36356561 2022
49
Outcomes of descending and thoracoabdominal aortic repair in connective tissue disorder patients. 62
36151718 2022
50
Misdiagnosis of Thoracic Aortic Disease Occurs Commonly in Emergency Transfers. 62
34838743 2022
Sources

Variations for Aortic Aneurysm

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ClinVar genetic disease variations for Aortic Aneurysm:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 ARIH1 NM_005744.5(ARIH1):c.43G>C (p.Glu15Gln) SNV Association
 996563 rs1052050835 GRCh37: 15:72767023-72767023
GRCh38: 15:72474682-72474682
2 ARIH1 NM_005744.5(ARIH1):c.511C>T (p.Arg171Ter) SNV Association
 996698 rs746505361 GRCh37: 15:72837228-72837228
GRCh38: 15:72544887-72544887
3 ARIH1 NM_005744.5(ARIH1):c.131A>G (p.Glu44Gly) SNV Association
 996699 rs2063786716 GRCh37: 15:72767111-72767111
GRCh38: 15:72474770-72474770
4 SMAD3 NM_005902.4(SMAD3):c.1A>G (p.Met1Val) SNV Pathogenic
 1172631 GRCh37: 15:67358493-67358493
GRCh38: 15:67066155-67066155
5 FBN1 NM_000138.5(FBN1):c.7754T>C (p.Ile2585Thr) SNV Pathogenic
 163462 rs727503054 GRCh37: 15:48712949-48712949
GRCh38: 15:48420752-48420752
6 COL3A1 NM_000090.4(COL3A1):c.505C>T (p.Leu169Phe) SNV Uncertain Significance
 161216 rs111391222 GRCh37: 2:189851842-189851842
GRCh38: 2:188987116-188987116
7 FBN1 NM_000138.5(FBN1):c.1900T>C (p.Ser634Pro) SNV Uncertain Significance
 568701 rs1566914005 GRCh37: 15:48797282-48797282
GRCh38: 15:48505085-48505085
8 TGFB2 NM_003238.6(TGFB2):c.356C>T (p.Pro119Leu) SNV Uncertain Significance
 213840 rs149533093 GRCh37: 1:218578520-218578520
GRCh38: 1:218405178-218405178
9 THSD1 NM_018676.4(THSD1):c.1051C>T (p.Gln351Ter) SNV Uncertain Significance
 1297020 GRCh37: 13:52960292-52960292
GRCh38: 13:52386157-52386157
10 MYH11, NDE1 NM_002474.3(MYH11):c.4942C>T (p.Arg1648Cys) SNV Uncertain Significance
 161318 rs369409348 GRCh37: 16:15814019-15814019
GRCh38: 16:15720162-15720162
Sources

Expression for Aortic Aneurysm

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Search GEO for disease gene expression data for Aortic Aneurysm.
Sources

Pathways for Aortic Aneurysm

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Pathways related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 64
Show member pathways
 13.75 ACTA2 EFEMP2 ELN FBN1 MYH11 MYLK
2
PAK Pathway 64
Show member pathways
 13.25 TGFBR2 TGFBR1 TGFB2 SMAD3 MYLK MYH11
3
Integrin Pathway 64
Show member pathways
 13.24 TGFBR2 TGFBR1 TGFB2 MYLK MYH11 MMP13
4
Phospholipase-C Pathway 64
Show member pathways
 13.01 ACTA2 EFEMP2 ELN FBN1 TGFB2 TGFBR1
5
Sertoli-Sertoli Cell Junction Dynamics 64
Show member pathways
 12.86 TGFBR2 TGFBR1 TGFB2 MYH11 ACTA2
6
NFAT and Cardiac Hypertrophy 64
Show member pathways
 12.8 TGFBR2 TGFBR1 TGFB2 MYLK ACTA2
7
Human Embryonic Stem Cell Pluripotency 64
Show member pathways
 12.41 TGFBR2 TGFBR1 TGFB2 SMAD3
8
Signaling by TGFB family members 66
Show member pathways
 12.34 TGFBR2 TGFBR1 TGFB2 SMAD3 FBN1
9
Cell cycle Regulation of G1/S transition (part 1) 22
Show member pathways
 12.31 TGFBR2 TGFBR1 TGFB2 SMAD3
10
Extracellular matrix organization 66
Show member pathways
 12.2 TGFB2 MMP13 MFAP5 LOX FBN1 FBLN5
11
Colorectal Cancer Metastasis 64
12.15 TGFBR2 TGFBR1 TGFB2 SMAD3
12
Epithelial to mesenchymal transition in colorectal cancer 74
12.13 TGFBR2 TGFBR1 TGFB2 SMAD3
13
Neuroinflammation and glutamatergic signaling 74
12.05 TGFBR2 TGFBR1 TGFB2 SMAD3
14
TGF-beta receptor signaling in skeletal dysplasias 74
Show member pathways
 11.93 TGFBR2 TGFBR1 SMAD3 FBN1
15
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.82 TGFBR2 TGFBR1 SMAD3
16
TGF-beta Signaling Pathways 65
11.82 SMAD3 TGFB2 TGFBR1 TGFBR2
17
Angiogenesis (CST) 3
11.79 MMP13 TGFB2 TGFBR1
18
Th17 Differentiation 65
Show member pathways
 11.78 TGFBR2 TGFBR1 TGFB2 SMAD3
19
7q11.23 copy number variation syndrome 74
11.76 FBN1 FBLN5 ELN
20
TGF-beta receptor signaling activates SMADs 66
Show member pathways
 11.76 TGFBR2 TGFBR1 TGFB2 SMAD3 FBN1
21
Development_TGF-beta receptor signaling 22
11.68 TGFBR2 TGFBR1 SMAD3
22
Burn wound healing 74
11.67 TGFB2 SMAD3 FBN1 ELN
23
Transcription_P53 signaling pathway 22
11.61 TGFBR2 TGFBR1 TGFB2 SMAD3 ACTA2
24
IL-2 Gene Expression in Activated and Quiescent T-Cells 64
Show member pathways
 11.58 TGFBR2 TGFBR1 TGFB2 SMAD3
25
TGF-beta receptor signaling 61
11.51 TGFBR2 TGFBR1 SMAD3
26
NRP1-triggered signaling pathways in pancreatic cancer 74
11.48 TGFBR2 TGFBR1 TGFB2 SMAD3
27
Smooth Muscle Contraction 66
11.45 ACTA2 MYH11 MYLK
28
Cell adhesion_Plasmin signaling 22
11.42 MMP13 TGFB2 TGFBR1 TGFBR2
29
Development_Glucocorticoid receptor signaling 22
11.4 TGFBR1 SMAD3 MMP13
30
Neovascularisation processes 74
11.31 TGFBR1 TGFB2 SMAD3
31
Extracellular vesicle-mediated signaling in recipient cells 74
11.19 TGFBR1 TGFB2 SMAD3
32
SMAD2/3 Phosphorylation Motif Mutants in Cancer 66
Show member pathways
 11.17 TGFBR2 TGFBR1 SMAD3
33
Elastic fibre formation 66
Show member pathways
 11.08 TGFB2 MFAP5 LOX FBN1 FBLN5 ELN
34
Angiotensin II receptor type 1 pathway 74
11.07 TGFBR2 TGFBR1 SMAD3 ACTA2
35
Glypican 1 network 61
10.96 TGFBR2 TGFBR1
36
G-protein signaling_Rap2B regulation pathway 22
10.96 TGFB2 MYLK FBN1 ELN EFEMP2
37
Hypothesized pathways in pathogenesis of cardiovascular disease 74
10.96 FBN1 SMAD3 TGFBR1 TGFBR2
38
IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types 65
10.92 TGFBR2 TGFBR1 TGFB2
39
Beta5 beta6 beta7 and beta8 integrin cell surface interactions 61
10.91 TGFBR1 FBN1
40
Canonical and non-canonical TGF-B signaling 74
10.69 TGFBR2 TGFBR1 SMAD3 LOX
Sources

GO Terms for Aortic Aneurysm

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Cellular components related to Aortic Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 10 EFEMP2 ELN FBLN5 FBN1 LOX MFAP5
2 microfibril GO:0001527 9.73 MFAP5 FBN1 EFEMP2
3 transforming growth factor beta ligand-receptor complex GO:0070021 9.62 TGFBR2 TGFBR1
4 elastic fiber GO:0071953 9.43 FBLN5 ELN EFEMP2
5 extracellular matrix GO:0031012 9.4 MMP13 MFAP5 LOX FBN1 FBLN5 ELN

Biological processes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 10.16 FBN1 LOX TGFB2 TGFBR1 TGFBR2
2 skeletal system development GO:0001501 10.1 FBN1 SMAD3 TGFB2 TGFBR1
3 cellular response to transforming growth factor beta stimulus GO:0071560 10.09 TGFBR1 SMAD3 FBN1
4 collagen fibril organization GO:0030199 10.07 TGFBR1 TGFB2 LOX
5 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 10.04 TGFBR2 TGFBR1 TGFB2
6 transforming growth factor beta receptor signaling pathway GO:0007179 10.01 TGFBR2 TGFBR1 TGFB2 SMAD3
7 ventricular septum morphogenesis GO:0060412 9.97 TGFBR2 TGFBR1 TGFB2
8 embryonic eye morphogenesis GO:0048048 9.91 MFAP5 FBN1
9 embryonic cranial skeleton morphogenesis GO:0048701 9.91 TGFBR2 TGFBR1 SMAD3
10 response to cholesterol GO:0070723 9.9 TGFBR2 TGFBR1
11 membranous septum morphogenesis GO:0003149 9.88 TGFBR2 TGFB2
12 positive regulation of epithelial to mesenchymal transition GO:0010718 9.86 SMAD3 TGFB2 TGFBR1 TGFBR2
13 activin receptor signaling pathway GO:0032924 9.85 TGFBR2 TGFBR1 SMAD3
14 wound healing GO:0042060 9.85 TGFBR2 TGFBR1 TGFB2 SMAD3 LOX
15 aorta smooth muscle tissue morphogenesis GO:0060414 9.84 MYLK EFEMP2
16 regulation of striated muscle tissue development GO:0016202 9.83 SMAD3 LOX
17 endocardial cushion fusion GO:0003274 9.81 TGFBR2 TGFB2
18 pathway-restricted SMAD protein phosphorylation GO:0060389 9.8 TGFBR2 TGFBR1 TGFB2
19 regulation of transforming growth factor beta2 production GO:0032909 9.78 TGFB2 SMAD3
20 growth plate cartilage development GO:0003417 9.75 TGFBR2 MMP13
21 regulation of multicellular organismal process GO:0051239 9.55 TGFBR2 TGFBR1
22 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.43 TGFBR2 TGFBR1 TGFB2
23 elastic fiber assembly GO:0048251 9.23 MYH11 LOX FBLN5 EFEMP2

Molecular functions related to Aortic Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.76 MFAP5 FBN1 ELN EFEMP2
2 type II transforming growth factor beta receptor binding GO:0005114 9.71 TGFBR1 TGFB2
3 SMAD binding GO:0046332 9.65 TGFBR2 TGFBR1 SMAD3
4 transforming growth factor beta receptor activity GO:0005024 9.62 TGFBR2 TGFBR1
5 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.54 TGFBR2 TGFBR1
6 type III transforming growth factor beta receptor binding GO:0034714 9.13 TGFBR2 TGFB2
7 extracellular matrix constituent conferring elasticity GO:0030023 9.1 FBN1 FBLN5 ELN
Sources

Sources for Aortic Aneurysm

About this section
2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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