MCID: ART016
MIFTS: 71

Aortic Aneurysm

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Aortic Aneurysm

MalaCards integrated aliases for Aortic Aneurysm:

Name: Aortic Aneurysm 12 77 30 6 44 3 45 15 17 74
Aortic Rupture 45 17 74
Thoracoabdominal Aortic Aneurysm, Ruptured 12 74
Ruptured Abdominal Aortic Aneurysm 12 74
Ruptured Thoracic Aortic Aneurysm 12 74
Aortic Aneurysm Without Mention of Rupture Nos 74
Thoracic Aortic Aneurysm Which Has Ruptured 12
Ruptured Thoracoabdominal Aortic Aneurysm 12
Abdominal Aortic Aneurysm, Ruptured 12
Thoracic Aortic Aneurysm, Ruptured 12
Ruptured Thoracic Aneurysm 12
Aortic Aneurysm, Ruptured 74
Ruptured Aortic Aneurysm 12

Classifications:



Summaries for Aortic Aneurysm

MedlinePlus : 44 An aneurysm is a bulge or "ballooning" in the wall of an artery. Arteries are blood vessels that carry oxygen-rich blood from the heart to other parts of the body. If an aneurysm grows large, it can burst and cause dangerous bleeding or even death. Most aneurysms are in the aorta, the main artery that runs from the heart through the chest and abdomen. There are two types of aortic aneurysm: Thoracic aortic aneurysms (TAA) - these occur in the part of the aorta running through the chest Abdominal aortic aneurysms (AAA) - these occur in the part of the aorta running through the abdomen Most aneurysms are found during tests done for other reasons. Some people are at high risk for aneurysms. It is important for them to get screening, because aneurysms can develop and become large before causing any symptoms. Screening is recommended for people between the ages of 65 and 75 if they have a family history, or if they are men who have smoked. Doctors use imaging tests to find aneurysms. Medicines and surgery are the two main treatments. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Aortic Aneurysm, also known as aortic rupture, is related to aortic aneurysm, familial thoracic 6 and aortic aneurysm, familial abdominal, 1, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Aortic Aneurysm is FBN1 (Fibrillin 1), and among its related pathways/superpathways are ERK Signaling and PAK Pathway. The drugs Acetazolamide and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and spinal cord, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size.

CDC : 3 An aortic aneurysm is a balloon-like bulge in the aorta, the large artery that carries blood from the heart through the chest and torso.

Wikipedia : 77 An aortic aneurysm is an enlargement (dilatation) of the aorta to greater than 1.5 times normal size.... more...

Related Diseases for Aortic Aneurysm

Diseases related to Aortic Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 485)
# Related Disease Score Top Affiliating Genes
1 aortic aneurysm, familial thoracic 6 34.6 ACTA2 MYH11 MYLK
2 aortic aneurysm, familial abdominal, 1 34.4 CDKN2B-AS1 ELN FBN1
3 familial thoracic aortic aneurysm and dissection 34.3 COL3A1 FBN1 SMAD3 TGFBR1 TGFBR2
4 familial abdominal aortic aneurysm 34.0 COL3A1 ELN FBN1 MYLK
5 aortic aneurysm, familial thoracic 2 33.8 ACTA2 FBN1 SLC2A10
6 loeys-dietz syndrome 2 33.5 MYH11 TGFBR2
7 loeys-dietz syndrome 1 33.3 COL3A1 FBN1 MYH11 SMAD3 TGFB2 TGFBR1
8 aortic aneurysm, familial thoracic 1 32.9 ACTA2 COL3A1 EFEMP2 ELN FBN1 HIF1A-AS1
9 loeys-dietz syndrome 32.7 ACTA2 COL3A1 FBN1 FBN2 MYH11 MYLK
10 loeys-dietz syndrome 4 32.6 SMAD3 TGFB2 TGFBR1 TGFBR2
11 marfan syndrome 32.1 ACTA2 COL3A1 ELN FBN1 FBN2 TGFBR1
12 cutis laxa, autosomal recessive, type ib 32.1 EFEMP2 ELN LOX
13 autosomal recessive cutis laxa type i 32.0 EFEMP2 ELN LOX TGFBR1 TGFBR2
14 loeys-dietz syndrome 3 31.4 ACTA2 COL3A1 FBN1 LOX MYH11 MYLK
15 aortic valve insufficiency 30.9 ELN FBN1 NOTCH1
16 aortic valve disease 1 30.7 ACTA2 ELN FBN1 FBN2 NOTCH1 TGFBR2
17 ehlers-danlos syndrome, vascular type 30.6 COL3A1 ELN
18 exfoliation syndrome 30.2 ELN FBN1 LOX
19 arterial tortuosity syndrome 29.9 EFEMP2 ELN SLC2A10 TGFBR1
20 connective tissue disease 29.7 ACTA2 COL3A1 ELN FBN1 FBN2
21 intracranial aneurysm 29.5 CDKN2B-AS1 COL3A1 ELN FBN2 LOX
22 cerebral arterial disease 29.4 ACTA2 CDKN2B-AS1 ELN
23 aortic disease 29.2 ACTA2 EFEMP2 ELN FBN1 MYH11 NOTCH1
24 aortic aneurysm, familial thoracic 4 12.7
25 aortic aneurysm, familial thoracic 10 12.7
26 aortic aneurysm, familial thoracic 9 12.7
27 aortic aneurysm, familial thoracic 11 12.7
28 aortic aneurysm, familial thoracic 8 12.6
29 aortic aneurysm, familial thoracic 7 12.6
30 aortic aneurysm, familial abdominal, 2 12.3
31 aortic aneurysm, familial abdominal, 4 12.3
32 aortic aneurysm, familial abdominal, 3 12.3
33 cutis laxa, autosomal dominant 1 11.6
34 meester-loeys syndrome 11.6
35 temporal arteritis 11.5
36 loeys-dietz syndrome 5 11.5
37 multisystemic smooth muscle dysfunction syndrome 11.5
38 phace association 11.2
39 cutis laxa, autosomal dominant 2 11.2
40 cutis laxa, autosomal dominant 3 11.2
41 cystic medial necrosis of aorta 11.2
42 ischemia 10.7
43 horseshoe kidney 10.7
44 paraplegia 10.6
45 peripheral vascular disease 10.5
46 aortic coarctation 10.5
47 arteries, anomalies of 10.5
48 aortitis 10.5
49 disseminated intravascular coagulation 10.5
50 compartment syndrome 10.4

Comorbidity relations with Aortic Aneurysm via Phenotypic Disease Network (PDN): (show all 15)


Acute Cystitis Acute Kidney Failure
Acute Vascular Insufficiency of Intestine Aortic Valve Disease 1
Cardiac Arrest Chronic Myocardial Ischemia
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Paralytic Ileus Peripheral Vascular Disease
Respiratory Failure

Graphical network of the top 20 diseases related to Aortic Aneurysm:



Diseases related to Aortic Aneurysm

Symptoms & Phenotypes for Aortic Aneurysm

UMLS symptoms related to Aortic Aneurysm:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

27 (show all 27)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 10.05 TGFBR2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 10.05 TGFB2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 10.05 TGFB2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 10.05 PRKG1 TGFBR2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 10.05 TGFBR2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 10.05 TGFBR1 TGFBR2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 10.05 TGFBR1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 10.05 TGFBR2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 10.05 TGFBR1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 10.05 PRKG1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 10.05 TGFBR1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 10.05 TGFB2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 10.05 TGFBR2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 10.05 TGFB2
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 10.05 PRKG1 TGFB2 TGFBR1 TGFBR2
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 10.05 TGFB2
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 10.05 TGFB2
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 10.05 PRKG1
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 10.05 TGFBR1
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 10.05 TGFBR2
21 Decreased viability GR00107-A-1 9.92 TGFBR2
22 Decreased viability GR00221-A-1 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
23 Decreased viability GR00221-A-2 9.92 COL3A1 PRKG1
24 Decreased viability GR00221-A-3 9.92 TGFBR2
25 Decreased viability GR00221-A-4 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
26 Decreased viability GR00301-A 9.92 PRKG1
27 Decreased viability GR00402-S-2 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2

MGI Mouse Phenotypes related to Aortic Aneurysm:

47 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.43 ACTA2 COL3A1 EFEMP2 FBN1 FBN2 LOX
2 cellular MP:0005384 10.29 BGN COL3A1 EFEMP2 FBN1 FBN2 MYH11
3 homeostasis/metabolism MP:0005376 10.25 BGN COL3A1 FBN1 FBN2 LOX MYH11
4 growth/size/body region MP:0005378 10.2 BGN COL3A1 FBN1 FBN2 MYH11 MYLK
5 immune system MP:0005387 10.18 BGN COL3A1 FBN1 MFAP5 MYLK NOTCH1
6 mortality/aging MP:0010768 10.17 BGN COL3A1 EFEMP2 FBN1 FBN2 LOX
7 digestive/alimentary MP:0005381 10.13 COL3A1 MYH11 MYLK NOTCH1 PRKG1 SMAD3
8 muscle MP:0005369 10.1 ACTA2 BGN COL3A1 EFEMP2 FBN1 FBN2
9 craniofacial MP:0005382 10.04 BGN FBN1 FBN2 NOTCH1 SMAD3 TGFB2
10 integument MP:0010771 10.02 BGN COL3A1 EFEMP2 FBN1 LOX MYH11
11 renal/urinary system MP:0005367 9.76 FBN1 MYH11 MYLK NOTCH1 PRKG1 SLC2A10
12 respiratory system MP:0005388 9.7 COL3A1 EFEMP2 FBN1 FBN2 LOX MYH11
13 skeleton MP:0005390 9.36 BGN EFEMP2 FBN1 FBN2 MFAP5 MYLK

Drugs & Therapeutics for Aortic Aneurysm

Drugs for Aortic Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 286)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
2
Angiotensin II Approved, Investigational Phase 4,Phase 3,Not Applicable 11128-99-7, 68521-88-0, 4474-91-3 172198
3
Atorvastatin Approved Phase 4,Phase 3,Phase 2 134523-00-5 60823
4
Morphine Approved, Investigational Phase 4,Phase 3 57-27-2 5288826
5
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
6
Iodine Approved, Investigational Phase 4,Not Applicable 7553-56-2 807
7
Ropivacaine Approved Phase 4,Phase 3 84057-95-4 175805 71273
8
Amlodipine Approved Phase 4,Phase 3,Phase 2,Not Applicable 88150-42-9 2162
9
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
10
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
11
Atenolol Approved Phase 4 29122-68-7 2249
12
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
13
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
14
Remifentanil Approved Phase 4,Phase 2 132875-61-7 60815
15
Prednisolone Approved, Vet_approved Phase 4,Not Applicable 50-24-8 5755
16
Prednisolone phosphate Approved, Vet_approved Phase 4,Not Applicable 302-25-0
17
Methylprednisolone Approved, Vet_approved Phase 4,Not Applicable 83-43-2 6741
18
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
19
Methylprednisolone hemisuccinate Approved Phase 4,Not Applicable 2921-57-5
20
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
21
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
22
Tranexamic Acid Approved Phase 4,Phase 3 1197-18-8 5526
23
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
24
Desflurane Approved Phase 4 57041-67-5 42113
25
Eplerenone Approved Phase 4 107724-20-9 443872 150310
26
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
27
Clevidipine Approved, Investigational Phase 4,Not Applicable 167221-71-8
28
Calcium Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 7440-70-2 271
29
Histidine Approved, Nutraceutical Phase 4 71-00-1 6274
30
Prednisolone hemisuccinate Experimental Phase 4,Not Applicable 2920-86-7
31 Carbonic Anhydrase Inhibitors Phase 4
32 Natriuretic Agents Phase 4,Phase 3,Not Applicable
33 diuretics Phase 4,Not Applicable
34 Anticonvulsants Phase 4
35 Angiotensin II Type 1 Receptor Blockers Phase 4,Phase 3,Not Applicable
36 Angiotensin Receptor Antagonists Phase 4,Phase 3,Not Applicable
37 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
38 Giapreza Phase 4,Phase 3,Not Applicable
39 Angiotensinogen Phase 4,Phase 3,Not Applicable
40 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
41 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
43 Analgesics Phase 4,Phase 3,Phase 2,Not Applicable
44 Analgesics, Opioid Phase 4,Phase 3,Phase 2
45 Narcotics Phase 4,Phase 3,Phase 2
46 Lipid Regulating Agents Phase 4,Phase 3,Phase 2
47 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3,Phase 2
48 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
49 Anticholesteremic Agents Phase 4,Phase 3,Phase 2
50 Hypolipidemic Agents Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 612)
# Name Status NCT ID Phase Drugs
1 Prophylactic Mesh Implantation After Abdominal Aortic Aneurysm Repair Unknown status NCT01353443 Phase 4
2 Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
3 Effectiveness of Acetazolamide in Reducing Paralysis of the Leg in Patients Undergoing Aortic Aneurysm Surgery Surgery Unknown status NCT01889498 Phase 4 Acetazolamide
4 Endovascular Repair of Descending Thoracic Aortic Aneurysms Completed NCT00802984 Phase 4
5 Study of the Effectiveness of Telmisartan in Slowing the Progression of Abdominal Aortic Aneurysms Completed NCT01683084 Phase 4 Telmisartan;Placebo
6 Endovascular Repair of Abdominal Aortic Aneurysms Completed NCT00803075 Phase 4
7 Standard Open Surgery Versus Endovascular Repair of Abdominal Aortic Aneurysm (AAA) Completed NCT00094575 Phase 4
8 GORE EXCLUDER® Endoprosthesis - Low Permeability in Treatment of Abdominal Aortic Aneurysms Completed NCT00593814 Phase 4
9 Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial) Completed NCT01904981 Phase 4 Beta-blocker-Atenolol 50mg, PO(peroral), Once daily;Angiotensin receptor blocker-Valsartan 80mg, PO(peroral), Once daily
10 Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities. Completed NCT02107170 Phase 4 Sevoflurane;Propofol;Remifentanil
11 Statin Use in Abdominal Aortic Aneurysm Repair Completed NCT01062802 Phase 4 Atorvastatin
12 Opioid-potentiated Volative Anaesthetic Vs. Remifentanil And Propofol During Abdominal Aortic Aneurysm Surgery Completed NCT00538421 Phase 4 Propofol;Sevoflurane
13 CUstodiol Versus RInger: whaT Is the Best Agent? Completed NCT02327611 Phase 4 Custodiol;Enriched Ringer's lactate solution
14 Prevalence of Abdominal Aortic Aneurysm in Patients Undergoing Coronary Angiography Completed NCT01239225 Phase 4
15 Epidural Versus Wound Infusion Plus Morphine Bolus in Open Abdominal Aortic Aneurysm Repair Completed NCT02677532 Phase 4 Paracetamol;Levobupivacaine wound infiltration;Levobupivacaine epidural bolus;Sufentanil epidural bolus;Morphine;Levobupivacaine plus sufentanil epidural infusion;Levobupivacaine wound infusion
16 Thoracoabdominal Arortic CTA Study Completed NCT02291718 Phase 4 Isovue
17 TAP-Block in Abdominal Aortic Surgery Completed NCT03657979 Phase 4 Ropivacaine;Placebo
18 Fibrinogen as an Alternative to FFP in Aortic Surgery. Completed NCT00994045 Phase 4
19 Vasculopathic Injury and Plasma as Endothelial Rescue - OCTAplas Trial (EudraCT no. 2014-000452-28) Completed NCT02253082 Phase 4 OctaplasLG®
20 Tranexamic Acid in Major Vascular Surgery Completed NCT02335359 Phase 4 tranexamic acid diluted in 100 ml of saline solution (loading dose);tranexamic acid undiluted (continous infusion);Placebo
21 Atorvastatin in Perioperative Vascular Surgery - Pilot Study Completed NCT00610545 Phase 4 Atorvastatin;Atorvastatin
22 A Controlled Trial of Effectiveness of a Backward Walking Program in Patients Recovering From Abdominal Aorta Surgery Completed NCT00819936 Phase 4
23 Study of Tomography of Nephrolithiasis Evaluation Completed NCT01451931 Phase 4
24 Randomized Trial of Pulsatile vs Non Pulsatile Perfusion on Short Term Changes in Kidney Function Using an Intra-Aortic Ballooon Pump During Cardioplegic Arrest in Patients Undergoing Myocardial Reperfusion Completed NCT00454428 Phase 4
25 OlmeSartan and Calcium Antagonists Randomized (OSCAR) Study Completed NCT00134160 Phase 4 Olmesartan medoxomil;Calcium channel blockers (amlodipine, azelnidipine)
26 Eplerenone in the Management of Abdominal Aortic Aneurysms Recruiting NCT02345590 Phase 4 Eplerenone
27 Predictors of AAA Expansion and/or Rupture Recruiting NCT03231397 Phase 4 Assess AAA rupture risk by PET-CTA scans;18F-fludeoxyglucose (FDG)
28 Randomized Preventive Vascular Screening Trial of 65-74 Year Old Men in the Central Region of Denmark Recruiting NCT00662480 Phase 4
29 Desflurane vs. Sevoflurane in Endovascular Aortic Repair Recruiting NCT03917186 Phase 4 Sevoflurane;Desflurane
30 Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Randomized Clinical Trial Recruiting NCT02678728 Phase 4 Dexmedetomidine;normal saline
31 Pilot Study of of Renal Arterial Sympathetic Denervation by Cryotherapy Active, not recruiting NCT02345603 Phase 4
32 Post-Market Study to Assess Outcomes of Patients Treated With AFX System Compared to Other EVAR Devices Enrolling by invitation NCT02407457 Phase 4
33 Comparison of Surveillance Versus Aortic Endografting for Small Aneurysm Repair Terminated NCT00118573 Phase 4
34 Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic Aneurysms Terminated NCT00409344 Phase 4 Dexmedetomidine
35 Long-term Benefit of Aortic Stent-graft in Patients With Distal Aortic Dissection Terminated NCT01354119 Phase 4
36 A Safety and Efficacy Study of Blood Pressure Control in Acute Aortic Emergencies - A Pilot Study (PROMPT) Terminated NCT01033370 Phase 4 clevidipine.
37 Bloodtranfusions After Aortic Surgery Terminated NCT02299947 Phase 4 Haemocomplettan P;Placebo
38 ATLANTIS:Extensive Type A Dissections and Thoracic/ Thoraco-Abdominal Aneurysms Repair With LupiAe Hybrid TechNique Withdrawn NCT01107366 Phase 4
39 NExT ERA: National Expertise Based Trial of Elective Repair of Abdominal Aortic Aneurysms: A Pilot Study Unknown status NCT00358085 Phase 3
40 34mm Cuff Study for Endovascular Repair of Abdominal Aortic Aneurysms Unknown status NCT00706394 Phase 2, Phase 3
41 Magnetic Resonance Imaging of Aortic Aneurysm Instability Unknown status NCT00794092 Phase 2, Phase 3 Sinerem administration
42 Efficacy of the Ultrasound-guided Transversus Abdominis Plane Block in Open Aortic Abdominal Aneurysm Repair Surgery Unknown status NCT02292667 Phase 3 PCA with Chlorhydrate of Morphine;Acetaminophen
43 Study of Aortic Root Reimplantation Procedure Unknown status NCT01787604 Phase 3
44 The Use of Nesiritide in Thoracic Aneurysm Repair to Prevent Acute Renal Failure Unknown status NCT00110201 Phase 3 Nesiritide
45 Clinical Evaluation of a Modular Extracorporeal Circulation Circuit Unknown status NCT02000544 Phase 3
46 Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) Trial of Cardiovascular Events in High-Risk Hypertensive Patients Unknown status NCT00125463 Phase 3 Candesartan cilexetil
47 Study of the Endovascular QUANTUM LP™ Stent Graft System in Abdominal Aortic Aneurysms (AAA) Completed NCT00233688 Phase 3
48 Curcumin to Prevent Complications After Elective Abdominal Aortic Aneurysm (AAA) Repair Completed NCT01225094 Phase 2, Phase 3 curcumin
49 Prevention of Colon Ischemia During Aortic Aneurysm (AAA) Repair Completed NCT00671203 Phase 3
50 ARBITER-II: Aorfix™ Bifurcated Safety and Performance Trial: Phase II, Angulated Vessels Completed NCT00442065 Phase 2, Phase 3

Search NIH Clinical Center for Aortic Aneurysm

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: aortic aneurysm

Genetic Tests for Aortic Aneurysm

Genetic tests related to Aortic Aneurysm:

# Genetic test Affiliating Genes
1 Aortic Aneurysm 30

Anatomical Context for Aortic Aneurysm

MalaCards organs/tissues related to Aortic Aneurysm:

42
Kidney, Heart, Spinal Cord, Testes, Lung, Smooth Muscle, Endothelial

Publications for Aortic Aneurysm

Articles related to Aortic Aneurysm:

(show top 50) (show all 6757)
# Title Authors Year
1
A Pilot Study of Protein Microarray for Simultaneous Analysis of 274 Cytokines Between Abdominal Aortic Aneurysm and Normal Aorta. ( 31018647 )
2019
2
microRNA expression profile in Smooth Muscle Cells isolated from thoracic aortic aneurysm samples. ( 31022558 )
2019
3
Klf4, Klf2, and Zfp148 activate autophagy-related genes in smooth muscle cells during aortic aneurysm formation. ( 31025534 )
2019
4
The influence of statins on aortic aneurysm after operation: A retrospective nationwide study. ( 31027125 )
2019
5
DAB2IP Expression in Abdominal Aortic Aneurysm: EZH2 and mir-363-3p as Potential Mediators. ( 31028191 )
2019
6
A Case of Myocardial Ischemia Detected by Global Longitudinal Strain Using Intraoperative Speckle-Tracking Echocardiography in a High-Risk Patient Undergoing Abdominal Aortic Aneurysm Repair. ( 31028240 )
2019
7
Long term survival and cardiovascular morbidity after elective open aortic aneurysm repair in patients with and without type 2 diabetes: a nationwide propensity-adjusted analysis. ( 31029685 )
2019
8
Abdominal aortic aneurysm as an IgG4-related disease. ( 31032886 )
2019
9
Efficacy of Unibody Bifurcated Endovascular Stent-Graft Repair in the Treatment of Abdominal Aortic Aneurysm. ( 31036115 )
2019
10
Variation in the choice of elective surgical procedure for abdominal aortic aneurysm in Spain. ( 31040686 )
2019
11
Numerical investigation of the effects of blood rheology and wall elasticity in abdominal aortic aneurysm under pulsatile flow conditions. ( 31045509 )
2019
12
Single-stage repair of thoracic aortic aneurysm and spinal cord compression. ( 31046395 )
2019
13
Impaired smooth muscle cell contractility as a novel concept of abdominal aortic aneurysm pathophysiology. ( 31048749 )
2019
14
Ventricular Dysfunction in a 40-Year-Old With Coronary Compression From Aortic Aneurysm Following Waterston Shunt and Complete Repair of Tetralogy of Fallot. ( 31049477 )
2019
15
Intercostal artery stent grafting to prevent paraplegia during endovascular treatment of an intercostal loop graft aneurysm after thoracoabdominal aortic aneurysm repair. ( 31053441 )
2019
16
ACR Appropriateness Criteria® Abdominal Aortic Aneurysm Follow-up (Without Repair). ( 31054747 )
2019
17
Abdominal Aortic Aneurysm Repair Readmissions and Disparities of Socioeconomic Status: A Multistate Analysis, 2007-2014. ( 31064731 )
2019
18
Management of Chronic Disseminated Intravascular Coagulation Associated with Aortic Aneurysm/Dissection. ( 31065391 )
2019
19
Late renal artery stent fracture with pseudoaneurysm after fenestrated endovascular abdominal aortic aneurysm repair. ( 31065610 )
2019
20
Ruptured abdominal aortic aneurysm mimicking acute coronary syndrome. ( 31066729 )
2019
21
Nationwide comparison of long-term survival and cardiovascular morbidity after acute aortic aneurysm repair in patients with and without type 2 diabetes. ( 31068268 )
2019
22
Smooth muscle-specific Gsα deletion exaggerates angiotensin II-induced abdominal aortic aneurysm formation in mice in vivo. ( 31071332 )
2019
23
Conformability and Efficacy of the Zenith Spiral Z Leg Compared with the Zenith Flex Leg in Endovascular Aortic Aneurysm Repair. ( 31071429 )
2019
24
Prediction of Survival After 48 Hours of Intensive Unit Care Following Repair of Ruptured Abdominal Aortic Aneurysm - Multicentric Study for External Validation of a New Prediction Score for 30-Day Mortality. ( 31075455 )
2019
25
Design of The PReferences for Open Versus Endovascular Repair of Abdominal Aortic Aneurysm (PROVE-AAA) Trial. ( 31075459 )
2019
26
Large diameter (≥29 mm) proximal aortic necks are associated with increased complication rates after endovascular repair for abdominal aortic aneurysm. ( 31075483 )
2019
27
Early Outcomes after Thoracoabdominal Aortic Aneurysm Repair with Hypothermic Circulatory Arrest. ( 31085168 )
2019
28
Percutaneous closure of aorto-right atrial fistula after ascending aortic aneurysm surgery using cardiac fusion imaging. ( 31085501 )
2019
29
Ascending aortic aneurysm exposed to direct impingement of eccentric flow jets through a tilting-disc valve prosthesis. ( 31086647 )
2019
30
Image Fusion Guidance for In Situ Laser Fenestration of Aortic Stent graft for Endovascular Repair of Complex Aortic Aneurysm: Feasibility, Efficacy and Overall Functional Success. ( 31087148 )
2019
31
A novel vision-based system for quantitative analysis of abdominal aortic aneurysm deformation. ( 31088563 )
2019
32
Infectious Aortitis with Abdominal Aortic Aneurysm in a 47-Year-Old Female with Systemic Lupus Erythematosus. ( 31089427 )
2019
33
Fluoroquinolones And Associated Risk Of Aortic Aneurysm: An FDA Warning. ( 31094137 )
2019
34
Expression levels of cathepsin L and cystatin C in a hyperglycemic environment were associated with aortic aneurysm development in a mouse model. ( 31096818 )
2019
35
Psychometric validation of three new condition-specific questionnaires to assess quality of life, symptoms and treatment satisfaction of patients with aortic aneurysm. ( 31098754 )
2019
36
Unusual Presentation of Ruptured Abdominal Aortic Aneurysm. ( 31104382 )
2019
37
Estimation of Abdominal Aortic Aneurysm Rupture Risk with Biomechanical Imaging Markers. ( 31109852 )
2019
38
Influence of earthquakes on the occurrence of aortic aneurysm ruptures. ( 31112028 )
2019
39
Predictors of in-hospital adverse events after endovascular aortic aneurysm repair. ( 30777687 )
2019
40
Long-term outcome of sac filling with fibrin sealant after endovascular aneurysm repair of abdominal aortic aneurysm with challenging aortic neck anatomy. ( 30777688 )
2019
41
Greater Aortic Stiffness and Pulsatile Arterial Load Are Associated With Larger Thoracic Aortic Aneurysm Size in Women. ( 30779642 )
2019
42
Impending rupture of aortic aneurysm eroding skin and sternum: a rare condition. ( 30781972 )
2019
43
3D segmentation of exterior wall surface of abdominal aortic aneurysm from CT images using variable neighborhood search. ( 30782525 )
2019
44
Systematic review of Quality of Life in persons with Hereditary Thoracic Aortic Aneurysm and Dissection diagnoses. ( 30788842 )
2019
45
Forecasting aortic aneurysm rupture: A systematic review of seasonal and atmospheric associations. ( 30792059 )
2019
46
Transforming growth factor β neutralization finely tunes macrophage phenotype in elastase-induced abdominal aortic aneurysm and is associated with an increase of arginase 1 expression in the aorta. ( 30792060 )
2019
47
A potential key mechanism in ascending aortic aneurysm development: Detection of a linear relationship between MMP-14/TIMP-2 ratio and active MMP-2. ( 30794673 )
2019
48
Response to 'Re. Importance of Surgeon Experience in the Relationship between Abdominal Aortic Aneurysm Surgery Volume and Peri-operative Mortality'. ( 30795928 )
2019
49
The 2019 update of the European abdominal aortic aneurysm guidelines. ( 30798841 )
2019
50
Regarding "Financial implications of coding inaccuracies in patients undergoing elective endovascular abdominal aortic aneurysm repair". ( 30798848 )
2019

Variations for Aortic Aneurysm

ClinVar genetic disease variations for Aortic Aneurysm:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 COL3A1 NM_000090.3(COL3A1): c.505C> T (p.Leu169Phe) single nucleotide variant Conflicting interpretations of pathogenicity rs111391222 GRCh37 Chromosome 2, 189851842: 189851842
2 COL3A1 NM_000090.3(COL3A1): c.505C> T (p.Leu169Phe) single nucleotide variant Conflicting interpretations of pathogenicity rs111391222 GRCh38 Chromosome 2, 188987116: 188987116
3 MYH11 NM_001040113.1(MYH11): c.4963C> T (p.Arg1655Cys) single nucleotide variant Uncertain significance rs369409348 GRCh37 Chromosome 16, 15814019: 15814019
4 MYH11 NM_001040113.1(MYH11): c.4963C> T (p.Arg1655Cys) single nucleotide variant Uncertain significance rs369409348 GRCh38 Chromosome 16, 15720162: 15720162
5 FBN1 NM_000138.4(FBN1): c.7754T> C (p.Ile2585Thr) single nucleotide variant Pathogenic/Likely pathogenic rs727503054 GRCh37 Chromosome 15, 48712949: 48712949
6 FBN1 NM_000138.4(FBN1): c.7754T> C (p.Ile2585Thr) single nucleotide variant Pathogenic/Likely pathogenic rs727503054 GRCh38 Chromosome 15, 48420752: 48420752
7 TGFB2 NM_001135599.3(TGFB2): c.440C> T (p.Pro147Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs149533093 GRCh37 Chromosome 1, 218578520: 218578520
8 TGFB2 NM_001135599.3(TGFB2): c.440C> T (p.Pro147Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs149533093 GRCh38 Chromosome 1, 218405178: 218405178

Expression for Aortic Aneurysm

Search GEO for disease gene expression data for Aortic Aneurysm.

Pathways for Aortic Aneurysm

Pathways related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 ACTA2 COL3A1 EFEMP2 ELN FBN1 FBN2
2
Show member pathways
13.2 ACTA2 MYH11 MYLK NOTCH1 SLC2A10 SMAD3
3
Show member pathways
13.14 ACTA2 COL3A1 EFEMP2 ELN FBN1 FBN2
4
Show member pathways
13.01 ACTA2 COL3A1 PRKG1 SMAD3 TGFBR1 TGFBR2
5
Show member pathways
12.95 ACTA2 COL3A1 EFEMP2 ELN FBN1 FBN2
6
Show member pathways
12.87 ACTA2 MYH11 PRKG1 TGFB2 TGFBR1 TGFBR2
7
Show member pathways
12.83 ACTA2 MYLK TGFB2 TGFBR1 TGFBR2
8 12.8 NOTCH1 SMAD3 TGFB2 TGFBR1 TGFBR2
9
Show member pathways
12.73 NOTCH1 SMAD3 TGFB2 TGFBR1 TGFBR2
10
Show member pathways
12.55 NOTCH1 SMAD3 TGFB2 TGFBR1 TGFBR2
11
Show member pathways
12.48 SMAD3 TGFB2 TGFBR1 TGFBR2
12
Show member pathways
12.46 BGN COL3A1 EFEMP2 ELN FBN1 FBN2
13
Show member pathways
12.44 SMAD3 TGFB2 TGFBR1 TGFBR2
14 12.32 SMAD3 TGFB2 TGFBR1 TGFBR2
15 12.22 NOTCH1 SMAD3 TGFB2 TGFBR1
16
Show member pathways
12.2 SMAD3 TGFB2 TGFBR1 TGFBR2
17 12.16 SMAD3 TGFB2 TGFBR1 TGFBR2
18 12.14 SMAD3 TGFB2 TGFBR1 TGFBR2
19 12.11 SMAD3 TGFB2 TGFBR1 TGFBR2
20
Show member pathways
12.05 SMAD3 TGFB2 TGFBR1 TGFBR2
21 12.04 ACTA2 MYLK SMAD3 TGFBR1
22
Show member pathways
12.03 ACTA2 COL3A1 EFEMP2 ELN FBN1 FBN2
23
Show member pathways
12 SMAD3 TGFB2 TGFBR1 TGFBR2
24 12 ACTA2 SMAD3 TGFB2 TGFBR1 TGFBR2
25 11.84 SMAD3 TGFB2 TGFBR1 TGFBR2
26
Show member pathways
11.83 SMAD3 TGFBR1 TGFBR2
27 11.81 NOTCH1 TGFB2 TGFBR1
28 11.81 SMAD3 TGFB2 TGFBR1 TGFBR2
29 11.8 COL3A1 SMAD3 TGFB2 TGFBR1 TGFBR2
30 11.71 SMAD3 TGFBR1 TGFBR2
31 11.71 SMAD3 TGFBR1 TGFBR2
32
Show member pathways
11.69 SMAD3 TGFBR1 TGFBR2
33 11.64 ACTA2 SMAD3 TGFB2 TGFBR1 TGFBR2
34 11.6 SMAD3 TGFBR1 TGFBR2
35
Show member pathways
11.57 SMAD3 TGFB2 TGFBR1 TGFBR2
36 11.53 SMAD3 TGFBR1 TGFBR2
37 11.51 TGFB2 TGFBR1 TGFBR2
38 11.46 TGFB2 TGFBR1 TGFBR2
39 11.35 ACTA2 MYLK TGFB2 TGFBR1 TGFBR2
40 11.32 ACTA2 MYH11 MYLK
41 11.15 SMAD3 TGFB2 TGFBR1 TGFBR2
42 11.05 SMAD3 TGFBR1 TGFBR2
43
Show member pathways
11.03 EFEMP2 ELN FBN1 FBN2 LOX MFAP5
44 10.94 COL3A1 EFEMP2 ELN FBN1 FBN2 MYLK
45 10.75 FBN1 FBN2 SMAD3 TGFBR1 TGFBR2

GO Terms for Aortic Aneurysm

Cellular components related to Aortic Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.96 BGN COL3A1 EFEMP2 ELN FBN1 FBN2
2 receptor complex GO:0043235 9.62 NOTCH1 SMAD3 TGFBR1 TGFBR2
3 extracellular matrix GO:0031012 9.5 BGN COL3A1 ELN FBN1 FBN2 LOX
4 microfibril GO:0001527 9.33 FBN1 FBN2 MFAP5
5 collagen-containing extracellular matrix GO:0062023 9.17 BGN COL3A1 ELN FBN1 FBN2 MFAP5

Biological processes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 49)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.95 CDKN2B-AS1 MYLK NOTCH1 SMAD3 TGFBR1
2 in utero embryonic development GO:0001701 9.94 NOTCH1 SMAD3 TGFBR1 TGFBR2
3 kidney development GO:0001822 9.88 FBN1 TGFB2 TGFBR1
4 muscle contraction GO:0006936 9.88 ACTA2 MYH11 MYLK
5 cell cycle arrest GO:0007050 9.88 NOTCH1 SMAD3 TGFB2 TGFBR1
6 skeletal system development GO:0001501 9.88 COL3A1 FBN1 SMAD3 TGFB2 TGFBR1
7 lung development GO:0030324 9.86 LOX NOTCH1 TGFBR2
8 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.83 SMAD3 TGFBR1 TGFBR2
9 cellular response to transforming growth factor beta stimulus GO:0071560 9.81 FBN1 SMAD3 TGFBR1
10 heart looping GO:0001947 9.8 NOTCH1 SMAD3 TGFBR2
11 embryonic limb morphogenesis GO:0030326 9.8 FBN2 NOTCH1 TGFB2
12 extracellular matrix organization GO:0030198 9.8 BGN COL3A1 ELN FBN1 FBN2 MFAP5
13 outflow tract morphogenesis GO:0003151 9.79 ELN NOTCH1 TGFBR2
14 transforming growth factor beta receptor signaling pathway GO:0007179 9.77 COL3A1 SMAD3 TGFB2 TGFBR1 TGFBR2
15 epithelial to mesenchymal transition GO:0001837 9.74 NOTCH1 TGFB2 TGFBR1
16 embryonic cranial skeleton morphogenesis GO:0048701 9.73 SMAD3 TGFBR1 TGFBR2
17 collagen fibril organization GO:0030199 9.73 COL3A1 LOX TGFB2 TGFBR1
18 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.71 TGFBR1 TGFBR2
19 ventricular trabecula myocardium morphogenesis GO:0003222 9.71 NOTCH1 TGFB2 TGFBR1
20 ventricular septum morphogenesis GO:0060412 9.71 NOTCH1 TGFB2 TGFBR1 TGFBR2
21 smooth muscle contraction GO:0006939 9.7 MYH11 MYLK
22 activin receptor signaling pathway GO:0032924 9.7 SMAD3 TGFBR1
23 cardiac epithelial to mesenchymal transition GO:0060317 9.7 NOTCH1 TGFB2 TGFBR1
24 heart development GO:0007507 9.7 COL3A1 FBN1 LOX NOTCH1 TGFB2 TGFBR1
25 endocardial cushion morphogenesis GO:0003203 9.69 NOTCH1 TGFB2
26 regulation of epithelial cell proliferation GO:0050678 9.69 NOTCH1 SMAD3
27 pathway-restricted SMAD protein phosphorylation GO:0060389 9.69 TGFB2 TGFBR1 TGFBR2
28 cardiac muscle cell proliferation GO:0060038 9.68 NOTCH1 TGFB2
29 negative regulation of immune response GO:0050777 9.68 COL3A1 TGFB2
30 pulmonary valve morphogenesis GO:0003184 9.68 NOTCH1 TGFB2
31 secondary palate development GO:0062009 9.68 TGFB2 TGFBR2
32 supramolecular fiber organization GO:0097435 9.67 COL3A1 MFAP5
33 cardiac left ventricle morphogenesis GO:0003214 9.67 NOTCH1 TGFBR2
34 membranous septum morphogenesis GO:0003149 9.67 TGFB2 TGFBR2
35 atrioventricular valve morphogenesis GO:0003181 9.67 NOTCH1 TGFB2 TGFBR2
36 response to cholesterol GO:0070723 9.66 TGFBR1 TGFBR2
37 somatic stem cell division GO:0048103 9.66 NOTCH1 TGFB2
38 coronary artery morphogenesis GO:0060982 9.65 NOTCH1 TGFBR1
39 embryonic eye morphogenesis GO:0048048 9.65 FBN1 FBN2
40 elastic fiber assembly GO:0048251 9.63 EFEMP2 LOX MYH11
41 aorta smooth muscle tissue morphogenesis GO:0060414 9.61 COL3A1 MYLK
42 endocardial cushion fusion GO:0003274 9.61 TGFB2 TGFBR2
43 glomerular mesangial cell development GO:0072144 9.6 ACTA2 NOTCH1
44 regulation of transforming growth factor beta2 production GO:0032909 9.59 SMAD3 TGFB2
45 sequestering of TGFbeta in extracellular matrix GO:0035583 9.58 FBN1 FBN2
46 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.43 TGFB2 TGFBR1 TGFBR2
47 positive regulation of epithelial to mesenchymal transition GO:0010718 9.35 NOTCH1 SMAD3 TGFB2 TGFBR1 TGFBR2
48 wound healing GO:0042060 9.1 COL3A1 LOX SMAD3 TGFB2 TGFBR1 TGFBR2
49 positive regulation of gene expression GO:0010628 10.04 ACTA2 CDKN2B-AS1 NOTCH1 SMAD3 TGFBR1

Molecular functions related to Aortic Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SMAD binding GO:0046332 9.46 COL3A1 SMAD3 TGFBR1 TGFBR2
2 transforming growth factor beta-activated receptor activity GO:0005024 9.37 TGFBR1 TGFBR2
3 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.32 TGFBR1 TGFBR2
4 type II transforming growth factor beta receptor binding GO:0005114 9.26 TGFB2 TGFBR1
5 extracellular matrix structural constituent GO:0005201 9.17 BGN COL3A1 EFEMP2 ELN FBN1 FBN2
6 extracellular matrix constituent conferring elasticity GO:0030023 9.13 ELN FBN1 FBN2

Sources for Aortic Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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