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MCID: ART016
MIFTS: 69

Aortic Aneurysm

Categories: Cardiovascular diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Aortic Aneurysm

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MalaCards integrated aliases for Aortic Aneurysm:

Name: Aortic Aneurysm 12 76 29 6 43 3 44 15 73
Thoracoabdominal Aortic Aneurysm, Ruptured 12 73
Ruptured Abdominal Aortic Aneurysm 12 73
Ruptured Thoracic Aortic Aneurysm 12 73
Aortic Rupture 44 73
Aortic Aneurysm Without Mention of Rupture Nos 73
Thoracic Aortic Aneurysm Which Has Ruptured 12
Ruptured Thoracoabdominal Aortic Aneurysm 12
Abdominal Aortic Aneurysm, Ruptured 12
Thoracic Aortic Aneurysm, Ruptured 12
Ruptured Thoracic Aneurysm 12
Aortic Aneurysm, Ruptured 73
Ruptured Aortic Aneurysm 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 33


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Summaries for Aortic Aneurysm

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MedlinePlus : 43 An aneurysm is a bulge or "ballooning" in the wall of an artery. Arteries are blood vessels that carry oxygen-rich blood from the heart to other parts of the body. If an aneurysm grows large, it can burst and cause dangerous bleeding or even death. Most aneurysms are in the aorta, the main artery that runs from the heart through the chest and abdomen. There are two types of aortic aneurysm: Thoracic aortic aneurysms (TAA) - these occur in the part of the aorta running through the chest Abdominal aortic aneurysms (AAA) - these occur in the part of the aorta running through the abdomen Most aneurysms are found during tests done for other reasons. Some people are at high risk for aneurysms. It is important for them to get screening, because aneurysms can develop and become large before causing any symptoms. Screening is recommended for people between the ages of 65 and 75 if they have a family history, or if they are men who have smoked. Doctors use imaging tests to find aneurysms. Medicines and surgery are the two main treatments. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Aortic Aneurysm, also known as thoracoabdominal aortic aneurysm, ruptured, is related to aortic aneurysm, familial thoracic 4 and aortic aneurysm, familial thoracic 6, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Aortic Aneurysm is CDKN2B-AS1 (CDKN2B Antisense RNA 1
Significantly reduced expression of all INK4/ARF transcripts (p15(INK4b),p16(INK4a),ARF and ANRIL) was found in PBTL of individuals harboring a common SNP (rs10757278) associated with increased risk of coronary artery disease,stroke and aortic aneurysm.
Dysfunction Pattern: Expression [differentially expressed]), and among its related pathways/superpathways are ERK Signaling and PAK Pathway. The drugs Angiotensin II and Atenolol have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and testes, and related phenotypes are Decreased viability and Decreased viability

CDC : 3 Thoracic Aortic Aneurysms

Disease Ontology : 12 An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size.

Wikipedia : 76 An aortic aneurysm is an enlargement (dilation) of the aorta to greater than 1.5 times normal size. They... more...

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Related Diseases for Aortic Aneurysm

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Diseases related to Aortic Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 332)
# Related Disease Score Top Affiliating Genes
1 aortic aneurysm, familial thoracic 4 35.1 FBN1 MYH11
2 aortic aneurysm, familial thoracic 6 34.7 ACTA2 MYH11 MYLK
3 familial thoracic aortic aneurysm and dissection 34.7 FBN1 SMAD3 TGFBR1 TGFBR2
4 loeys-dietz syndrome 1 34.3 TGFBR1 TGFBR2
5 aortic aneurysm, familial thoracic 2 34.1 ACTA2 FBN1 SLC2A10
6 familial abdominal aortic aneurysm 33.9 COL3A1 ELN FBN1 MYLK
7 aortic aneurysm, familial abdominal, 1 33.8 CDKN2B-AS1 ELN FBN1
8 loeys-dietz syndrome 31.6 ACTA2 COL3A1 FBN1 FBN2 MYH11 MYLK
9 marfan syndrome 31.5 ACTA2 COL3A1 ELN FBN1 FBN2 TGFBR1
10 aortic valve insufficiency 30.3 ELN FBN1 NOTCH1
11 aortic valve disease 2 30.3 ELN FBN1 NOTCH1
12 aortic aneurysm, familial thoracic 1 30.2 ACTA2 COL3A1 EFEMP2 ELN FBN1 HIF1A-AS1
13 aortic valve disease 1 30.1 ELN FBN1 NOTCH1
14 exfoliation syndrome 30.1 ELN FBN1 LOX
15 orthostatic intolerance 30.1 ELN FBN1 FBN2
16 connective tissue disease 29.6 ACTA2 COL3A1 ELN FBN1 FBN2
17 arterial tortuosity syndrome 29.6 EFEMP2 ELN SLC2A10 TGFBR1
18 cerebral arterial disease 29.0 ACTA2 CDKN2B-AS1 ELN
19 intracranial aneurysm 28.5 CDKN2B-AS1 COL3A1 ELN FBN2 LOX
20 aneurysm 28.1 ACTA2 BGN COL3A1 ELN FBN1 FBN2
21 aortic disease 27.6 ACTA2 EFEMP2 ELN FBN1 NOTCH1 PRKG1
22 aortic aneurysm, familial thoracic 10 12.4
23 aortic aneurysm, familial thoracic 7 12.4
24 aortic aneurysm, familial thoracic 9 12.4
25 aortic aneurysm, familial thoracic 11 12.4
26 aortic aneurysm, familial thoracic 8 12.3
27 aortic aneurysm, familial abdominal, 2 12.1
28 aortic aneurysm, familial abdominal, 4 12.1
29 aortic aneurysm, familial abdominal, 3 12.0
30 loeys-dietz syndrome 2 11.8
31 temporal arteritis 11.3
32 multisystemic smooth muscle dysfunction syndrome 11.3
33 cutis laxa, autosomal dominant 1 11.1
34 meester-loeys syndrome 11.1
35 autosomal recessive cutis laxa type i 11.1
36 phace association 11.0
37 loeys-dietz syndrome 3 11.0
38 cutis laxa, autosomal dominant 2 11.0
39 cutis laxa, autosomal recessive, type ib 11.0
40 loeys-dietz syndrome 4 11.0
41 loeys-dietz syndrome 5 11.0
42 cutis laxa, autosomal dominant 3 11.0
43 cystic medial necrosis of aorta 11.0
44 transient hypogammaglobulinemia of infancy 10.8 TGFBR1 TGFBR2
45 pseudoxanthoma elasticum-like papillary dermal elastolysis 10.8 ELN FBN1
46 late-onset focal dermal elastosis 10.8 ELN FBN1
47 ehlers-danlos syndrome, hypermobility type 10.7 COL3A1 FBN1
48 transient hypogammaglobulinemia 10.7 TGFBR1 TGFBR2
49 chronic actinic dermatitis 10.6 ELN FBN1
50 marden-walker syndrome 10.6 FBN1 FBN2

Comorbidity relations with Aortic Aneurysm via Phenotypic Disease Network (PDN): (show all 15)


Acute Cystitis Acute Kidney Failure
Acute Vascular Insufficiency of Intestine Aortic Valve Disease 1
Cardiac Arrest Chronic Myocardial Ischemia
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Paralytic Ileus Peripheral Vascular Disease
Respiratory Failure

Graphical network of the top 20 diseases related to Aortic Aneurysm:



Diseases related to Aortic Aneurysm
Sources

Symptoms & Phenotypes for Aortic Aneurysm

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UMLS symptoms related to Aortic Aneurysm:


angina pectoris, chest pain, edema

GenomeRNAi Phenotypes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00107-A-1 9.92 TGFBR2
2 Decreased viability GR00221-A-1 9.92 TGFBR2 MYLK PRKG1 TGFBR1 COL3A1
3 Decreased viability GR00221-A-2 9.92 PRKG1 COL3A1
4 Decreased viability GR00221-A-3 9.92 TGFBR2
5 Decreased viability GR00221-A-4 9.92 MYLK TGFBR2 PRKG1 TGFBR1 COL3A1
6 Decreased viability GR00301-A 9.92 PRKG1
7 Decreased viability GR00402-S-2 9.92 MYLK PRKG1 TGFBR1 COL3A1 TGFBR2

MGI Mouse Phenotypes related to Aortic Aneurysm:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.41 TGFBR2 NOTCH1 TGFB2 PRKG1 TGFBR1 SLC2A10
2 cellular MP:0005384 10.27 SMAD3 TGFBR2 NOTCH1 TGFB2 MYH11 PRKG1
3 homeostasis/metabolism MP:0005376 10.21 TGFBR1 MYLK SMAD3 TGFBR2 NOTCH1 TGFB2
4 growth/size/body region MP:0005378 10.2 TGFBR1 MYLK SMAD3 TGFBR2 NOTCH1 TGFB2
5 immune system MP:0005387 10.18 SMAD3 TGFBR2 NOTCH1 TGFB2 PRKG1 SLC2A10
6 mortality/aging MP:0010768 10.17 SMAD3 TGFBR2 NOTCH1 TGFB2 MYH11 PRKG1
7 digestive/alimentary MP:0005381 10.13 SMAD3 TGFBR2 NOTCH1 TGFB2 MYH11 PRKG1
8 muscle MP:0005369 10.1 TGFBR2 NOTCH1 TGFB2 PRKG1 TGFBR1 MYLK
9 integument MP:0010771 10.02 SMAD3 NOTCH1 MYH11 TGFBR1 COL3A1 LOX
10 renal/urinary system MP:0005367 9.76 MYLK SMAD3 NOTCH1 TGFB2 MYH11 PRKG1
11 respiratory system MP:0005388 9.7 TGFBR2 NOTCH1 TGFB2 MYH11 TGFBR1 SLC2A10
12 skeleton MP:0005390 9.36 TGFBR2 NOTCH1 TGFB2 TGFBR1 MYLK SMAD3
Sources

Drugs & Therapeutics for Aortic Aneurysm

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Drugs for Aortic Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 250)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Angiotensin II Approved, Investigational Phase 4,Phase 3,Not Applicable 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
2
Atenolol Approved Phase 4 29122-68-7 2249
3
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
4
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
5
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
6
Amlodipine Approved Phase 4,Phase 3,Phase 2,Not Applicable 88150-42-9 2162
7
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
8
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
9
Remifentanil Approved Phase 4 132875-61-7 60815
10
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
11
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
12
Methylprednisolone Approved, Vet_approved Phase 4,Not Applicable 83-43-2 6741
13
Prednisolone Approved, Vet_approved Phase 4,Not Applicable 50-24-8 5755
14
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
15
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
16
Morphine Approved, Investigational Phase 4,Phase 3 57-27-2 5288826
17
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
18
Iodine Approved, Investigational Phase 4,Not Applicable 7553-56-2 807
19
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
20
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
21
Eplerenone Approved Phase 4 107724-20-9 150310 443872
22
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
23
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
24
Tranexamic Acid Approved Phase 4,Phase 3 1197-18-8 5526
25
Clevidipine Approved, Investigational Phase 4,Not Applicable 167221-71-8
26
Histidine Approved, Nutraceutical Phase 4 71-00-1 6274
27 Adrenergic Agents Phase 4,Early Phase 1
28 Adrenergic Antagonists Phase 4,Early Phase 1
29 Adrenergic beta-1 Receptor Antagonists Phase 4,Early Phase 1
30 Adrenergic beta-Antagonists Phase 4,Early Phase 1
31 Angiotensin II Type 1 Receptor Blockers Phase 4,Phase 3,Not Applicable
32 Angiotensin Receptor Antagonists Phase 4,Phase 3,Not Applicable
33 Angiotensinogen Phase 4,Phase 3,Not Applicable
34 Anti-Arrhythmia Agents Phase 4,Phase 3,Not Applicable
35 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
36 Autonomic Agents Phase 4,Not Applicable,Early Phase 1
37 Neurotransmitter Agents Phase 4,Phase 2,Early Phase 1
38 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
39 Sympatholytics Phase 4,Early Phase 1
40 Anticonvulsants Phase 4
41 Carbonic Anhydrase Inhibitors Phase 4
42 diuretics Phase 4,Not Applicable
43 Natriuretic Agents Phase 4,Phase 3,Not Applicable
44 Anesthetics Phase 4,Phase 3,Phase 1,Not Applicable
45 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable
46 Anticholesteremic Agents Phase 4,Phase 3,Phase 2
47 Antimetabolites Phase 4,Phase 2,Phase 3
48 Atorvastatin Calcium Phase 4,Phase 3,Phase 2 134523-03-8
49 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
50 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 551)
# Name Status NCT ID Phase Drugs
1 Prophylactic Mesh Implantation After Abdominal Aortic Aneurysm Repair Unknown status NCT01353443 Phase 4
2 Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial) Unknown status NCT01904981 Phase 4 Beta-blocker-Atenolol 50mg, PO(peroral), Once daily;Angiotensin receptor blocker-Valsartan 80mg, PO(peroral), Once daily
3 Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
4 Effectiveness of Acetazolamide in Reducing Paralysis of the Leg in Patients Undergoing Aortic Aneurysm Surgery Surgery Unknown status NCT01889498 Phase 4 Acetazolamide
5 Endovascular Repair of Descending Thoracic Aortic Aneurysms Completed NCT00802984 Phase 4
6 Study of the Effectiveness of Telmisartan in Slowing the Progression of Abdominal Aortic Aneurysms Completed NCT01683084 Phase 4 Telmisartan;Placebo
7 Endovascular Repair of Abdominal Aortic Aneurysms Completed NCT00803075 Phase 4
8 Standard Open Surgery Versus Endovascular Repair of Abdominal Aortic Aneurysm (AAA) Completed NCT00094575 Phase 4
9 GORE EXCLUDER® Endoprosthesis - Low Permeability in Treatment of Abdominal Aortic Aneurysms Completed NCT00593814 Phase 4
10 Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities. Completed NCT02107170 Phase 4 Sevoflurane;Propofol;Remifentanil
11 Statin Use in Abdominal Aortic Aneurysm Repair Completed NCT01062802 Phase 4 Atorvastatin
12 Opioid-potentiated Volative Anaesthetic Vs. Remifentanil And Propofol During Abdominal Aortic Aneurysm Surgery Completed NCT00538421 Phase 4 Propofol;Sevoflurane
13 CUstodiol Versus RInger: whaT Is the Best Agent? Completed NCT02327611 Phase 4 Custodiol;Enriched Ringer's lactate solution
14 Prevalence of Abdominal Aortic Aneurysm in Patients Undergoing Coronary Angiography Completed NCT01239225 Phase 4
15 Epidural Versus Wound Infusion Plus Morphine Bolus in Open Abdominal Aortic Aneurysm Repair Completed NCT02677532 Phase 4 Paracetamol;Levobupivacaine wound infiltration;Levobupivacaine epidural bolus;Sufentanil epidural bolus;Morphine;Levobupivacaine plus sufentanil epidural infusion;Levobupivacaine wound infusion
16 Thoracoabdominal Arortic CTA Study Completed NCT02291718 Phase 4 Isovue
17 Fibrinogen as an Alternative to FFP in Aortic Surgery. Completed NCT00994045 Phase 4
18 Vasculopathic Injury and Plasma as Endothelial Rescue - OCTAplas Trial (EudraCT no. 2014-000452-28) Completed NCT02253082 Phase 4 OctaplasLG®
19 Atorvastatin in Perioperative Vascular Surgery - Pilot Study Completed NCT00610545 Phase 4 Atorvastatin;Atorvastatin
20 A Controlled Trial of Effectiveness of a Backward Walking Program in Patients Recovering From Abdominal Aorta Surgery Completed NCT00819936 Phase 4
21 Study of Tomography of Nephrolithiasis Evaluation Completed NCT01451931 Phase 4
22 Randomized Trial of Pulsatile vs Non Pulsatile Perfusion on Short Term Changes in Kidney Function Using an Intra-Aortic Ballooon Pump During Cardioplegic Arrest in Patients Undergoing Myocardial Reperfusion Completed NCT00454428 Phase 4
23 OlmeSartan and Calcium Antagonists Randomized (OSCAR) Study Completed NCT00134160 Phase 4 Olmesartan medoxomil;Calcium channel blockers (amlodipine, azelnidipine)
24 Eplerenone in the Management of Abdominal Aortic Aneurysms Recruiting NCT02345590 Phase 4 Eplerenone
25 Randomized Preventive Vascular Screening Trial of 65-74 Year Old Men in the Central Region of Denmark Recruiting NCT00662480 Phase 4
26 Bloodtranfusions After Aortic Surgery Recruiting NCT02299947 Phase 4 Haemocomplettan P;Placebo
27 Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Randomized Clinical Trial Recruiting NCT02678728 Phase 4 Dexmedetomidine;normal saline
28 Pilot Study of of Renal Arterial Sympathetic Denervation by Cryotherapy Active, not recruiting NCT02345603 Phase 4
29 Tranexamic Acid in Major Vascular Surgery Active, not recruiting NCT02335359 Phase 4 tranexamic acid diluted in 100 ml of saline solution (loading dose);tranexamic acid undiluted (continous infusion);Placebo
30 Post-Market Study to Assess Outcomes of Patients Treated With AFX System Compared to Other EVAR Devices Enrolling by invitation NCT02407457 Phase 4
31 Comparison of Surveillance Versus Aortic Endografting for Small Aneurysm Repair Terminated NCT00118573 Phase 4
32 Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic Aneurysms Terminated NCT00409344 Phase 4 Dexmedetomidine
33 Long-term Benefit of Aortic Stent-graft in Patients With Distal Aortic Dissection Terminated NCT01354119 Phase 4
34 A Safety and Efficacy Study of Blood Pressure Control in Acute Aortic Emergencies - A Pilot Study (PROMPT) Terminated NCT01033370 Phase 4 clevidipine.
35 ATLANTIS:Extensive Type A Dissections and Thoracic/ Thoraco-Abdominal Aneurysms Repair With LupiAe Hybrid TechNique Withdrawn NCT01107366 Phase 4
36 NExT ERA: National Expertise Based Trial of Elective Repair of Abdominal Aortic Aneurysms: A Pilot Study Unknown status NCT00358085 Phase 3
37 34mm Cuff Study for Endovascular Repair of Abdominal Aortic Aneurysms Unknown status NCT00706394 Phase 2, Phase 3
38 Magnetic Resonance Imaging of Aortic Aneurysm Instability Unknown status NCT00794092 Phase 2, Phase 3 Sinerem administration
39 Study of Aortic Root Reimplantation Procedure Unknown status NCT01787604 Phase 3
40 The Use of Nesiritide in Thoracic Aneurysm Repair to Prevent Acute Renal Failure Unknown status NCT00110201 Phase 3 Nesiritide
41 Clinical Evaluation of a Modular Extracorporeal Circulation Circuit Unknown status NCT02000544 Phase 3
42 Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) Trial of Cardiovascular Events in High-Risk Hypertensive Patients Unknown status NCT00125463 Phase 3 Candesartan cilexetil
43 Study of the Endovascular QUANTUM LPâ„¢ Stent Graft System in Abdominal Aortic Aneurysms (AAA) Completed NCT00233688 Phase 3
44 Curcumin to Prevent Complications After Elective Abdominal Aortic Aneurysm (AAA) Repair Completed NCT01225094 Phase 2, Phase 3 curcumin
45 Prevention of Colon Ischemia During Aortic Aneurysm (AAA) Repair Completed NCT00671203 Phase 3
46 ARBITER-II: Aorfixâ„¢ Bifurcated Safety and Performance Trial: Phase II, Angulated Vessels Completed NCT00442065 Phase 2, Phase 3
47 Melatonin and Cardiac Outcome After Major Surgery Completed NCT00315926 Phase 2, Phase 3 Melatonin;Placebo
48 VALOR: The Talent Thoracic Stent Graft System Clinical Study Completed NCT00604799 Phase 2, Phase 3
49 Powerlink Bifurcated Stent Graft Long-Term Follow-up Study Completed NCT00543270 Phase 2, Phase 3
50 Conservative Aortic Valve Surgery for Aortic Insufficiency and Aneurysms of the Aortic Root. CAVIAAR Completed NCT00478803 Phase 3

Search NIH Clinical Center for Aortic Aneurysm

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: aortic aneurysm

Sources

Genetic Tests for Aortic Aneurysm

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Genetic tests related to Aortic Aneurysm:

# Genetic test Affiliating Genes
1 Aortic Aneurysm 29
Sources

Anatomical Context for Aortic Aneurysm

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MalaCards organs/tissues related to Aortic Aneurysm:

41
Kidney, Heart, Testes, Spinal Cord, Lung, Smooth Muscle, Endothelial
Sources

Publications for Aortic Aneurysm

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Articles related to Aortic Aneurysm:

(show top 50) (show all 3294)
# Title Authors Year
1
Concomitant mycotic abdominal aortic aneurysm and lumbartuberculous spondylitis with cauda equina syndrome: a rare condition - a case report and literature review. ( 29479482 )
2018
2
Giant dissecting aortic aneurysm in a chronic amphetamine user. ( 29975172 )
2018
3
Ten-year experience of the thoraco-abdominal aortic aneurysm treatment using a hybrid thoracic endovascular aortic repair. ( 29415193 )
2018
4
Modulation of Immune-Inflammatory Responses in Abdominal Aortic Aneurysm: Emerging Molecular Targets. ( 29967801 )
2018
5
Thoracic aortic aneurysm is an independent factor associated with diffuse idiopathic skeletal hyperostosis. ( 29701101 )
2018
6
A case of a rectal stricture related to ischemic proctitis following rupture of an aortic aneurysm. ( 29399616 )
2018
7
Endovascular treatment of thoracoabdominal aortic aneurysm in Loeys-Dietz syndrome. ( 29756196 )
2018
8
Renal Fenestration Closure Technique in fenestrated endovascular repair for para-renal aortic aneurysm. ( 29421424 )
2018
9
The Effect of a Non-peptide Angiotensin II type 2 receptor Agonist, Compound 21, on Aortic Aneurysm Growth in a Mouse Model of Marfan Syndrome. ( 29300219 )
2018
10
Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm. ( 29432192 )
2018
11
Comparative effectiveness of open surgery versus endovascular repair for hemodynamically stable and unstable ruptured abdominal aortic aneurysm. ( 29979402 )
2018
12
Understanding abdominal aortic aneurysm epidemiology: socioeconomic position affects outcome. ( 29967003 )
2018
13
Patients with end-stage renal disease have poor outcomes after endovascular abdominal aortic aneurysm repair. ( 29945838 )
2018
14
Screening for Abdominal Aortic Aneurysm During Transthoracic Echocardiography: A Systematic Review and Meta-analysis. ( 29433798 )
2018
15
Systematic Review of Circulating, Biomechanical, and Genetic Markers for the Prediction of Abdominal Aortic Aneurysm Growth and Rupture. ( 29960996 )
2018
16
Increased risk of malignancy in patients with an aortic aneurysm: a nationwide population-based retrospective study. ( 29416815 )
2018
17
Abdominal compartment syndrome and ruptured aortic aneurysm: Validation of a predictive test (SCA-AAR). ( 29923999 )
2018
18
Impact of abdominal aortic aneurysm screening on quality ofA life. ( 29405273 )
2018
19
Defective p27 phosphorylation at serine 10 affects vascular reactivity and increases abdominal aortic aneurysm development via Cox-2 activation. ( 29408196 )
2018
20
MiR-155 deletion reduces ischemia-induced paralysis in an aortic aneurysm repair mouse model: Utility of immunohistochemistry and histopathology in understanding etiology of spinal cord paralysis. ( 29966831 )
2018
21
Early growth response factor-1 DNA enzyme 1 inhibits the formation of abdominal aortic aneurysm in rats. ( 29977360 )
2018
22
Aortitis as a Rare Cause of Aortic Aneurysm and Valve Regurgitation: Is Repair Precluded? ( 29662705 )
2018
23
Association of carotid atherosclerosis and stiffness with abdominal aortic aneurysm: The atherosclerosis risk in communities (ARIC) study. ( 29407878 )
2018
24
The Association of Biomarkers of Inflammation and Extracellular Matrix Degradation With the Risk of Abdominal Aortic Aneurysm: The ARIC Study. ( 29945457 )
2018
25
Case Image: Treatment of aortic coarctation, saccular thoracic aortic aneurysm, and corresponding feeding collateral vessel with a fully percutaneous endovascular approach. ( 29664433 )
2018
26
Impact of Medical Therapy on Late Morbidity and Mortality After Aortic Aneurysm Repair for Aortitis. ( 29408240 )
2018
27
Endovascular repair for inflammatory abdominal aortic aneurysm. ( 29945204 )
2018
28
Aortic Aneurysm as a Complication of Granulomatosis with Polyangiitis Successfully Treated with Prednisolone and Cyclophosphamide: A Case Report and Review of the Literature. ( 29971178 )
2018
29
Postoperative Chylothorax after Thoracoabdominal Aortic Aneurysm Repair. ( 29428620 )
2018
30
Embelin inhibits abdominal aortic aneurysm through decreasing ILa896a89induced STAT3 and NFa89I_B inactivation. ( 29956759 )
2018
31
Bacille Calmette-GuAcrin (BCG) spondylitis with adjacent mycotic aortic aneurysm after intravesical BCG therapy: a case report and literature review. ( 29954321 )
2018
32
Spinal cord injury in endovascular thoracoabdominal aortic aneurysm repair: prevalence, risk factors and preventive strategies. ( 29424186 )
2018
33
A custom-made TreovanceAr abdominal aortic aneurysm endograft to correct late failure of trombone technique with a tube endograft. ( 29421425 )
2018
34
Spinal meningioma, aortic aneurysms and the missing link of observation: the anchoring heuristic approach. ( 29525765 )
2018
35
Thiol/disulphide homeostasis in thoracic aortic aneurysm and acute aortic syndrome. ( 29436236 )
2018
36
Rare Case of Both Left Atrial and Ventricular Compression by Dissecting Aortic Aneurysm. ( 29952308 )
2018
37
The incidence of incisional hernia after aortic aneurysm is not higher than after benign colorectal interventions: AA retrospective control-matched cohort study. ( 29950793 )
2018
38
Increased Risk of Peripheral Arterial Disease in Patients With Abdominal Aortic Aneurysm: A Retrospective Cohort Study (Version 5). ( 29444589 )
2018
39
Snorkel Technique for Inferior Mesenteric Artery During Endovascular Repair of Abdominal Aortic Aneurysm. ( 29433410 )
2018
40
Combination of Octopus and Periscope Techniques for the Management of Visceral Branches From Type V Thoracoabdominal Aortic Aneurysm: A Case Report. ( 29954257 )
2018
41
Abdominal aortic aneurysm calcification: trying to identify a reliable semiquantitative method. ( 29430885 )
2018
42
Macrophage CD31 Signaling in DissectingA Aortic Aneurysm. ( 29957231 )
2018
43
Double Inferior Vena Cava with Azygos Continuation and Retroaortic Left Renal Vein Associated with Juxtarenal Abdominal Aortic Aneurysm Surgery. ( 29682119 )
2018
44
Screening key genes for abdominal aortic aneurysm based on gene expression omnibus dataset. ( 29439675 )
2018
45
Ischemic Preconditioning of the Spinal Cord to Prevent Spinal Cord Ischemia during Endovascular Repair of Thoraco-Abdominal Aortic Aneurysm - First Clinical Experience. ( 29969429 )
2018
46
Rupture of an Abdominal Aortic Aneurysm in a Young Man with Marfan Syndrome. ( 29421423 )
2018
47
An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm. ( 29520069 )
2018
48
Nationwide analysis of risk factors for in-hospital mortality in patients undergoing abdominal aortic aneurysm repair. ( 29417985 )
2018
49
Clinical outcomes of total endovascular aneurysm repair for aortic aneurysms involving the proximal anastomotic aneurysm following initial open repair for infrarenal abdominal aortic aneurysm. ( 29421415 )
2018
50
Randomized clinical trial of remote ischaemic preconditioning versus no preconditioning in the prevention of perioperative myocardial infarction during open surgery for ruptured abdominal aortic aneurysm. ( 29951634 )
2018
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Variations for Aortic Aneurysm

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ClinVar genetic disease variations for Aortic Aneurysm:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 COL3A1 NM_000090.3(COL3A1): c.505C> T (p.Leu169Phe) single nucleotide variant Conflicting interpretations of pathogenicity rs111391222 GRCh37 Chromosome 2, 189851842: 189851842
2 COL3A1 NM_000090.3(COL3A1): c.505C> T (p.Leu169Phe) single nucleotide variant Conflicting interpretations of pathogenicity rs111391222 GRCh38 Chromosome 2, 188987116: 188987116
3 MYH11 NM_001040113.1(MYH11): c.4963C> T (p.Arg1655Cys) single nucleotide variant Uncertain significance rs369409348 GRCh37 Chromosome 16, 15814019: 15814019
4 MYH11 NM_001040113.1(MYH11): c.4963C> T (p.Arg1655Cys) single nucleotide variant Uncertain significance rs369409348 GRCh38 Chromosome 16, 15720162: 15720162
5 FBN1 NM_000138.4(FBN1): c.7754T> C (p.Ile2585Thr) single nucleotide variant Pathogenic/Likely pathogenic rs727503054 GRCh37 Chromosome 15, 48712949: 48712949
6 FBN1 NM_000138.4(FBN1): c.7754T> C (p.Ile2585Thr) single nucleotide variant Pathogenic/Likely pathogenic rs727503054 GRCh38 Chromosome 15, 48420752: 48420752
7 TGFB2 NM_003238.3(TGFB2): c.356C> T (p.Pro119Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs149533093 GRCh37 Chromosome 1, 218578520: 218578520
8 TGFB2 NM_003238.3(TGFB2): c.356C> T (p.Pro119Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs149533093 GRCh38 Chromosome 1, 218405178: 218405178
Sources

Expression for Aortic Aneurysm

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Search GEO for disease gene expression data for Aortic Aneurysm.
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Pathways for Aortic Aneurysm

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Pathways related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 64
Show member pathways
 13.71 ACTA2 COL3A1 EFEMP2 ELN FBN1 FBN2
2
PAK Pathway 64
Show member pathways
 13.19 ACTA2 MYH11 MYLK NOTCH1 SLC2A10 SMAD3
3
Integrin Pathway 64
Show member pathways
 13.14 ACTA2 COL3A1 EFEMP2 ELN FBN1 FBN2
4
Circadian entrainment 37
Show member pathways
 12.99 ACTA2 COL3A1 PRKG1 SMAD3 TGFBR1 TGFBR2
5
Phospholipase-C Pathway 64
Show member pathways
 12.95 ACTA2 COL3A1 EFEMP2 ELN FBN1 FBN2
6
Sertoli-Sertoli Cell Junction Dynamics 64
Show member pathways
 12.85 ACTA2 MYH11 PRKG1 TGFB2 TGFBR1 TGFBR2
7
NFAT and Cardiac Hypertrophy 64
Show member pathways
 12.82 ACTA2 MYLK TGFB2 TGFBR1 TGFBR2
8
Pathways in cancer 37
12.79 NOTCH1 SMAD3 TGFB2 TGFBR1 TGFBR2
9
Gastric cancer 37
Show member pathways
 12.73 NOTCH1 SMAD3 TGFB2 TGFBR1 TGFBR2
10
Degradation of the extracellular matrix 66
Show member pathways
 12.46 BGN COL3A1 EFEMP2 ELN FBN1 FBN2
11
Human Embryonic Stem Cell Pluripotency 64
Show member pathways
 12.42 SMAD3 TGFB2 TGFBR1 TGFBR2
12
Th17 cell differentiation 37
Show member pathways
 12.38 NOTCH1 SMAD3 TGFB2 TGFBR1 TGFBR2
13
HTLV-I infection 37
12.37 SMAD3 TGFB2 TGFBR1 TGFBR2
14
Th1 Differentiation Pathway 65
Show member pathways
 12.22 SMAD3 TGFB2 TGFBR1 TGFBR2
15
Wnt / Hedgehog / Notch 4
12.19 NOTCH1 SMAD3 TGFB2 TGFBR1
16
Cell cycle Role of SCF complex in cell cycle regulation 22
Show member pathways
 12.17 SMAD3 TGFB2 TGFBR1 TGFBR2
17
Colorectal Cancer Metastasis 64
12.14 SMAD3 TGFB2 TGFBR1 TGFBR2
18
Cellular senescence (KEGG) 37
12.11 SMAD3 TGFB2 TGFBR1 TGFBR2
19
Hippo signaling pathway 37
12.09 SMAD3 TGFB2 TGFBR1 TGFBR2
20
FoxO signaling pathway 37
Show member pathways
 12.02 SMAD3 TGFB2 TGFBR1 TGFBR2
21
Apelin signaling pathway 37
12.01 ACTA2 MYLK SMAD3 TGFBR1
22
SMAD Signaling Network 64
11.98 ACTA2 SMAD3 TGFB2 TGFBR1 TGFBR2
23
TGF-beta Signaling Pathways 65
11.83 SMAD3 TGFB2 TGFBR1 TGFBR2
24
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.82 SMAD3 TGFBR1 TGFBR2
25
Angiogenesis (CST) 4
11.8 NOTCH1 TGFB2 TGFBR1
26
AGE-RAGE signaling pathway in diabetic complications 37
11.8 COL3A1 SMAD3 TGFB2 TGFBR1 TGFBR2
27
TGF-beta signaling pathway (KEGG) 37
11.75 SMAD3 TGFB2 TGFBR1 TGFBR2
28
Loss of Function of SMAD2/3 in Cancer 66
Show member pathways
 11.7 LOX SMAD3 TGFBR1 TGFBR2
29
Adherens junction 37
11.69 SMAD3 TGFBR1 TGFBR2
30
Development_TGF-beta receptor signaling 22
11.69 SMAD3 TGFBR1 TGFBR2
31
TGF-beta receptor signaling activates SMADs 66
Show member pathways
 11.67 SMAD3 TGFBR1 TGFBR2
32
TGF-beta Receptor Signaling (WikiPathways) 1
11.58 SMAD3 TGFBR1 TGFBR2
33
TGF-beta receptor signaling (Pathway Interaction Database) 1
11.51 SMAD3 TGFBR1 TGFBR2
34
Cell adhesion_Plasmin signaling 22
11.48 TGFB2 TGFBR1 TGFBR2
35
IL-2 Gene Expression in Activated and Quiescent T-Cells 64
Show member pathways
 11.31 SMAD3 TGFB2 TGFBR1 TGFBR2
36
Smooth Muscle Contraction 66
11.3 ACTA2 MYH11 MYLK
37
Extracellular vesicle-mediated signaling in recipient cells 1
11.15 SMAD3 TGFB2 TGFBR1 TGFBR2
38
NTHi-Induced Signaling 64
11.03 SMAD3 TGFBR1 TGFBR2
39
Elastic fibre formation 66
Show member pathways
 11.03 EFEMP2 ELN FBN1 FBN2 LOX MFAP5
40
Hypothesized Pathways in Pathogenesis of Cardiovascular Disease 1
10.75 FBN1 FBN2 SMAD3 TGFBR1 TGFBR2
Sources

GO Terms for Aortic Aneurysm

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Cellular components related to Aortic Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.97 ACTA2 BGN COL3A1 EFEMP2 FBN1 LOX
2 extracellular region GO:0005576 9.96 BGN COL3A1 EFEMP2 ELN FBN1 FBN2
3 receptor complex GO:0043235 9.62 NOTCH1 SMAD3 TGFBR1 TGFBR2
4 extracellular matrix GO:0031012 9.17 BGN COL3A1 ELN FBN1 FBN2 MFAP5
5 transforming growth factor beta receptor complex GO:0070022 9.16 TGFBR1 TGFBR2
6 microfibril GO:0001527 9.13 FBN1 FBN2 MFAP5

Biological processes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.94 MYLK NOTCH1 SMAD3 TGFBR1
2 in utero embryonic development GO:0001701 9.94 NOTCH1 SMAD3 TGFBR1 TGFBR2
3 skeletal system development GO:0001501 9.89 COL3A1 FBN1 SMAD3 TGFB2 TGFBR1
4 muscle contraction GO:0006936 9.88 ACTA2 MYH11 MYLK
5 kidney development GO:0001822 9.88 FBN1 TGFB2 TGFBR1
6 cell cycle arrest GO:0007050 9.88 NOTCH1 SMAD3 TGFB2 TGFBR1
7 lung development GO:0030324 9.87 LOX NOTCH1 TGFBR2
8 extracellular matrix disassembly GO:0022617 9.85 ELN FBN1 FBN2
9 roof of mouth development GO:0060021 9.85 TGFB2 TGFBR1 TGFBR2
10 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.83 SMAD3 TGFBR1 TGFBR2
11 heart looping GO:0001947 9.81 NOTCH1 SMAD3 TGFBR2
12 cellular response to transforming growth factor beta stimulus GO:0071560 9.8 FBN1 SMAD3 TGFBR1
13 embryonic limb morphogenesis GO:0030326 9.8 FBN2 NOTCH1 TGFB2
14 heart development GO:0007507 9.8 COL3A1 FBN1 LOX NOTCH1 TGFB2 TGFBR1
15 blood vessel development GO:0001568 9.79 COL3A1 LOX TGFBR2
16 transforming growth factor beta receptor signaling pathway GO:0007179 9.77 COL3A1 SMAD3 TGFB2 TGFBR1 TGFBR2
17 epithelial to mesenchymal transition GO:0001837 9.75 NOTCH1 TGFB2 TGFBR1
18 embryonic cranial skeleton morphogenesis GO:0048701 9.74 SMAD3 TGFBR1 TGFBR2
19 collagen fibril organization GO:0030199 9.73 COL3A1 LOX TGFB2 TGFBR1
20 ventricular trabecula myocardium morphogenesis GO:0003222 9.71 NOTCH1 TGFB2 TGFBR1
21 ventricular septum morphogenesis GO:0060412 9.71 NOTCH1 TGFB2 TGFBR1 TGFBR2
22 endocardial cushion morphogenesis GO:0003203 9.7 NOTCH1 TGFB2
23 activin receptor signaling pathway GO:0032924 9.7 SMAD3 TGFBR1
24 cardiac epithelial to mesenchymal transition GO:0060317 9.7 NOTCH1 TGFB2 TGFBR1
25 regulation of epithelial cell proliferation GO:0050678 9.69 NOTCH1 SMAD3
26 cardiac muscle cell proliferation GO:0060038 9.69 NOTCH1 TGFB2
27 pathway-restricted SMAD protein phosphorylation GO:0060389 9.69 TGFB2 TGFBR1 TGFBR2
28 supramolecular fiber organization GO:0097435 9.68 COL3A1 MFAP5
29 secondary palate development GO:0062009 9.68 TGFB2 TGFBR2
30 somatic stem cell division GO:0048103 9.67 NOTCH1 TGFB2
31 cardiac left ventricle morphogenesis GO:0003214 9.67 NOTCH1 TGFBR2
32 pulmonary valve morphogenesis GO:0003184 9.67 NOTCH1 TGFB2
33 membranous septum morphogenesis GO:0003149 9.66 TGFB2 TGFBR2
34 response to cholesterol GO:0070723 9.66 TGFBR1 TGFBR2
35 embryonic eye morphogenesis GO:0048048 9.65 FBN1 FBN2
36 coronary artery morphogenesis GO:0060982 9.65 NOTCH1 TGFBR1
37 atrioventricular valve morphogenesis GO:0003181 9.65 NOTCH1 TGFB2 TGFBR2
38 elastic fiber assembly GO:0048251 9.63 EFEMP2 LOX MYH11
39 aorta smooth muscle tissue morphogenesis GO:0060414 9.61 COL3A1 MYLK
40 glomerular mesangial cell development GO:0072144 9.61 ACTA2 NOTCH1
41 regulation of transforming growth factor beta2 production GO:0032909 9.6 SMAD3 TGFB2
42 regulation of cellular response to growth factor stimulus GO:0090287 9.59 FBN1 FBN2
43 endocardial cushion fusion GO:0003274 9.56 TGFB2 TGFBR2
44 sequestering of TGFbeta in extracellular matrix GO:0035583 9.55 FBN1 FBN2
45 positive regulation of epithelial to mesenchymal transition GO:0010718 9.55 NOTCH1 SMAD3 TGFB2 TGFBR1 TGFBR2
46 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.5 TGFB2 TGFBR1 TGFBR2
47 extracellular matrix organization GO:0030198 9.5 BGN COL3A1 ELN FBN1 FBN2 LOX
48 wound healing GO:0042060 9.1 COL3A1 LOX SMAD3 TGFB2 TGFBR1 TGFBR2

Molecular functions related to Aortic Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta binding GO:0050431 9.43 TGFBR1 TGFBR2
2 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity GO:0004702 9.4 TGFBR1 TGFBR2
3 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.37 TGFBR1 TGFBR2
4 type II transforming growth factor beta receptor binding GO:0005114 9.32 TGFB2 TGFBR1
5 transforming growth factor beta-activated receptor activity GO:0005024 9.26 TGFBR1 TGFBR2
6 SMAD binding GO:0046332 9.26 COL3A1 SMAD3 TGFBR1 TGFBR2
7 extracellular matrix structural constituent GO:0005201 9.17 BGN COL3A1 EFEMP2 ELN FBN1 FBN2
8 extracellular matrix constituent conferring elasticity GO:0030023 9.16 FBN1 FBN2
Sources

Sources for Aortic Aneurysm

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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