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MCID: ART016
MIFTS: 71

Aortic Aneurysm

Categories: Blood diseases, Cardiovascular diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Aortic Aneurysm

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MalaCards integrated aliases for Aortic Aneurysm:

Name: Aortic Aneurysm 12 77 30 6 44 45 15 17 74 3
Aortic Rupture 45 17 74
Thoracoabdominal Aortic Aneurysm, Ruptured 12 74
Ruptured Abdominal Aortic Aneurysm 12 74
Ruptured Thoracic Aortic Aneurysm 12 74
Aortic Aneurysm Without Mention of Rupture Nos 74
Thoracic Aortic Aneurysm Which Has Ruptured 12
Ruptured Thoracoabdominal Aortic Aneurysm 12
Abdominal Aortic Aneurysm, Ruptured 12
Thoracic Aortic Aneurysm, Ruptured 12
Ruptured Thoracic Aneurysm 12
Aortic Aneurysm, Ruptured 74
Ruptured Aortic Aneurysm 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34


Sources

Summaries for Aortic Aneurysm

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MedlinePlus : 44 An aneurysm is a bulge or "ballooning" in the wall of an artery. Arteries are blood vessels that carry oxygen-rich blood from the heart to other parts of the body. If an aneurysm grows large, it can burst and cause dangerous bleeding or even death. Most aneurysms are in the aorta, the main artery that runs from the heart through the chest and abdomen. There are two types of aortic aneurysm: Thoracic aortic aneurysms (TAA) - these occur in the part of the aorta running through the chest Abdominal aortic aneurysms (AAA) - these occur in the part of the aorta running through the abdomen Most aneurysms are found during tests done for other reasons. Some people are at high risk for aneurysms. It is important for them to get screening, because aneurysms can develop and become large before causing any symptoms. Screening is recommended for people between the ages of 65 and 75 if they have a family history, or if they are men who have smoked. Doctors use imaging tests to find aneurysms. Medicines and surgery are the two main treatments. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Aortic Aneurysm, also known as aortic rupture, is related to aortic aneurysm, familial abdominal, 1 and aortic aneurysm, familial thoracic 6, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Aortic Aneurysm is FBN1 (Fibrillin 1), and among its related pathways/superpathways are ERK Signaling and PAK Pathway. The drugs Acetazolamide and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and testes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size.

CDC : 3 An aortic aneurysm is a balloon-like bulge in the aorta, the large artery that carries blood from the heart through the chest and torso.

Wikipedia : 77 An aortic aneurysm is an enlargement (dilatation) of the aorta to greater than 1.5 times normal size.... more...

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Related Diseases for Aortic Aneurysm

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Diseases related to Aortic Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 479)
# Related Disease Score Top Affiliating Genes
1 aortic aneurysm, familial abdominal, 1 34.4 CDKN2B-AS1 ELN FBN1
2 aortic aneurysm, familial thoracic 6 34.4 ACTA2 MYH11 MYLK
3 familial thoracic aortic aneurysm and dissection 34.3 COL3A1 FBN1 SMAD3 TGFBR1 TGFBR2
4 familial abdominal aortic aneurysm 34.0 COL3A1 ELN FBN1 MYLK
5 aortic aneurysm, familial thoracic 2 33.8 ACTA2 FBN1 SLC2A10
6 loeys-dietz syndrome 1 33.3 COL3A1 FBN1 MYH11 SMAD3 TGFB2 TGFBR1
7 loeys-dietz syndrome 2 33.2 MYH11 TGFBR2
8 aortic aneurysm, familial thoracic 1 32.9 ACTA2 COL3A1 EFEMP2 ELN FBN1 HIF1A-AS1
9 loeys-dietz syndrome 32.6 ACTA2 COL3A1 FBN1 FBN2 MYH11 MYLK
10 loeys-dietz syndrome 4 32.1 SMAD3 TGFB2 TGFBR1 TGFBR2
11 marfan syndrome 32.0 ACTA2 COL3A1 ELN FBN1 FBN2 TGFBR1
12 cutis laxa, autosomal recessive, type ib 32.0 EFEMP2 ELN LOX
13 autosomal recessive cutis laxa type i 32.0 EFEMP2 ELN LOX TGFBR1 TGFBR2
14 loeys-dietz syndrome 3 30.9 ACTA2 COL3A1 FBN1 LOX MYH11 MYLK
15 aortic valve insufficiency 30.8 ELN FBN1 NOTCH1
16 exfoliation syndrome 30.2 ELN FBN1 LOX
17 aortic valve disease 1 30.1 ACTA2 ELN FBN1 FBN2 NOTCH1 TGFBR2
18 arterial tortuosity syndrome 29.9 EFEMP2 ELN SLC2A10 TGFBR1
19 connective tissue disease 29.7 ACTA2 COL3A1 ELN FBN1 FBN2
20 intracranial aneurysm 29.5 CDKN2B-AS1 COL3A1 ELN FBN2 LOX
21 cerebral arterial disease 29.4 ACTA2 CDKN2B-AS1 ELN
22 aortic disease 29.2 ACTA2 EFEMP2 ELN FBN1 MYH11 NOTCH1
23 aortic aneurysm, familial thoracic 4 12.7
24 aortic aneurysm, familial thoracic 10 12.6
25 aortic aneurysm, familial thoracic 7 12.6
26 aortic aneurysm, familial thoracic 9 12.6
27 aortic aneurysm, familial thoracic 11 12.6
28 aortic aneurysm, familial thoracic 8 12.5
29 aortic aneurysm, familial abdominal, 2 12.3
30 aortic aneurysm, familial abdominal, 4 12.3
31 aortic aneurysm, familial abdominal, 3 12.2
32 temporal arteritis 11.5
33 multisystemic smooth muscle dysfunction syndrome 11.4
34 phakomatosis spilorosea 11.4
35 cutis laxa, autosomal dominant 1 11.3
36 meester-loeys syndrome 11.3
37 phace association 11.2
38 cutis laxa, autosomal dominant 2 11.2
39 loeys-dietz syndrome 5 11.2
40 cutis laxa, autosomal dominant 3 11.2
41 cardiovascular system disease 11.2
42 cystic medial necrosis of aorta 11.2
43 ischemia 10.7
44 horseshoe kidney 10.7
45 paraplegia 10.6
46 humero-ulnar synostosis 10.5
47 arteries, anomalies of 10.5
48 aortitis 10.5
49 aortic coarctation 10.5
50 disseminated intravascular coagulation 10.4

Comorbidity relations with Aortic Aneurysm via Phenotypic Disease Network (PDN): (show all 15)


Acute Cystitis Acute Kidney Failure
Acute Vascular Insufficiency of Intestine Aortic Valve Disease 1
Cardiac Arrest Chronic Myocardial Ischemia
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Paralytic Ileus Peripheral Vascular Disease
Respiratory Failure

Graphical network of the top 20 diseases related to Aortic Aneurysm:



Diseases related to Aortic Aneurysm
Sources

Symptoms & Phenotypes for Aortic Aneurysm

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UMLS symptoms related to Aortic Aneurysm:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

27 (show all 25)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 10.02 TGFBR2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 10.02 TGFB2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 10.02 TGFB2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 10.02 PRKG1 TGFBR2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 10.02 TGFBR2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 10.02 TGFBR1 TGFBR2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 10.02 TGFBR1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 10.02 TGFBR2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 10.02 TGFBR1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 10.02 PRKG1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 10.02 TGFB2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 10.02 TGFBR2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 10.02 TGFB2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 10.02 PRKG1 TGFB2 TGFBR1 TGFBR2
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 10.02 TGFB2
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 10.02 TGFB2
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 10.02 PRKG1
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 10.02 TGFBR2
19 Decreased viability GR00107-A-1 9.92 TGFBR2
20 Decreased viability GR00221-A-1 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
21 Decreased viability GR00221-A-2 9.92 COL3A1 PRKG1
22 Decreased viability GR00221-A-3 9.92 TGFBR2
23 Decreased viability GR00221-A-4 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
24 Decreased viability GR00301-A 9.92 PRKG1
25 Decreased viability GR00402-S-2 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2

MGI Mouse Phenotypes related to Aortic Aneurysm:

47 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.43 ACTA2 COL3A1 EFEMP2 FBN1 FBN2 LOX
2 cellular MP:0005384 10.29 BGN COL3A1 EFEMP2 FBN1 FBN2 MYH11
3 homeostasis/metabolism MP:0005376 10.25 BGN COL3A1 FBN1 FBN2 LOX MYH11
4 growth/size/body region MP:0005378 10.2 BGN COL3A1 FBN1 FBN2 MYH11 MYLK
5 immune system MP:0005387 10.18 BGN COL3A1 FBN1 MFAP5 MYLK NOTCH1
6 mortality/aging MP:0010768 10.17 BGN COL3A1 EFEMP2 FBN1 FBN2 LOX
7 digestive/alimentary MP:0005381 10.13 COL3A1 MYH11 MYLK NOTCH1 PRKG1 SMAD3
8 muscle MP:0005369 10.1 ACTA2 BGN COL3A1 EFEMP2 FBN1 FBN2
9 craniofacial MP:0005382 10.04 BGN FBN1 FBN2 NOTCH1 SMAD3 TGFB2
10 integument MP:0010771 10.02 BGN COL3A1 EFEMP2 FBN1 LOX MYH11
11 renal/urinary system MP:0005367 9.76 FBN1 MYH11 MYLK NOTCH1 PRKG1 SLC2A10
12 respiratory system MP:0005388 9.7 COL3A1 EFEMP2 FBN1 FBN2 LOX MYH11
13 skeleton MP:0005390 9.36 BGN EFEMP2 FBN1 FBN2 MFAP5 MYLK
Sources

Drugs & Therapeutics for Aortic Aneurysm

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Drugs for Aortic Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 285)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
2
Angiotensin II Approved, Investigational Phase 4,Phase 3,Not Applicable 68521-88-0, 11128-99-7, 4474-91-3 172198 65143
3
Atorvastatin Approved Phase 4,Phase 3,Phase 2 134523-00-5 60823
4
Morphine Approved, Investigational Phase 4,Phase 3 57-27-2 5288826
5
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
6
Iodine Approved, Investigational Phase 4,Not Applicable 7553-56-2 807
7
Ropivacaine Approved Phase 4,Phase 3 84057-95-4 71273 175805
8
Amlodipine Approved Phase 4,Phase 3,Phase 2,Not Applicable 88150-42-9 2162
9
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
10
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
11
Atenolol Approved Phase 4 29122-68-7 2249
12
Remifentanil Approved Phase 4,Phase 2 132875-61-7 60815
13
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
14
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
15
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
16
Prednisolone phosphate Approved, Vet_approved Phase 4,Not Applicable 302-25-0
17
Prednisolone Approved, Vet_approved Phase 4,Not Applicable 50-24-8 5755
18
Methylprednisolone hemisuccinate Approved Phase 4,Not Applicable 2921-57-5
19
Methylprednisolone Approved, Vet_approved Phase 4,Not Applicable 83-43-2 6741
20
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
21
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
22
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 130881 158781
23
Eplerenone Approved Phase 4 107724-20-9 150310 443872
24
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
25
Tranexamic Acid Approved Phase 4,Phase 3 1197-18-8 5526
26
Clevidipine Approved, Investigational Phase 4,Not Applicable 167221-71-8
27
Calcium Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 7440-70-2 271
28
Histidine Approved, Nutraceutical Phase 4 71-00-1 6274
29
Prednisolone hemisuccinate Experimental Phase 4,Not Applicable 2920-86-7
30 Carbonic Anhydrase Inhibitors Phase 4
31 Natriuretic Agents Phase 4,Phase 3,Not Applicable
32 diuretics Phase 4,Not Applicable
33 Anticonvulsants Phase 4
34 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
35 Giapreza Phase 4,Phase 3,Not Applicable
36 Angiotensin II Type 1 Receptor Blockers Phase 4,Phase 3,Not Applicable
37 Angiotensinogen Phase 4,Phase 3,Not Applicable
38 Angiotensin Receptor Antagonists Phase 4,Phase 3,Not Applicable
39 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
40 Analgesics Phase 4,Phase 3,Phase 2,Not Applicable
41 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Narcotics Phase 4,Phase 3,Phase 2
43 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
44 Analgesics, Opioid Phase 4,Phase 3,Phase 2
45 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3,Phase 2
46 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
47 Hypolipidemic Agents Phase 4,Phase 3,Phase 2
48 Lipid Regulating Agents Phase 4,Phase 3,Phase 2
49 Anticholesteremic Agents Phase 4,Phase 3,Phase 2
50 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 603)
# Name Status NCT ID Phase Drugs
1 Prophylactic Mesh Implantation After Abdominal Aortic Aneurysm Repair Unknown status NCT01353443 Phase 4
2 Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
3 Effectiveness of Acetazolamide in Reducing Paralysis of the Leg in Patients Undergoing Aortic Aneurysm Surgery Surgery Unknown status NCT01889498 Phase 4 Acetazolamide
4 Endovascular Repair of Descending Thoracic Aortic Aneurysms Completed NCT00802984 Phase 4
5 Study of the Effectiveness of Telmisartan in Slowing the Progression of Abdominal Aortic Aneurysms Completed NCT01683084 Phase 4 Telmisartan;Placebo
6 Endovascular Repair of Abdominal Aortic Aneurysms Completed NCT00803075 Phase 4
7 Standard Open Surgery Versus Endovascular Repair of Abdominal Aortic Aneurysm (AAA) Completed NCT00094575 Phase 4
8 GORE EXCLUDER® Endoprosthesis - Low Permeability in Treatment of Abdominal Aortic Aneurysms Completed NCT00593814 Phase 4
9 Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial) Completed NCT01904981 Phase 4 Beta-blocker-Atenolol 50mg, PO(peroral), Once daily;Angiotensin receptor blocker-Valsartan 80mg, PO(peroral), Once daily
10 Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities. Completed NCT02107170 Phase 4 Sevoflurane;Propofol;Remifentanil
11 Statin Use in Abdominal Aortic Aneurysm Repair Completed NCT01062802 Phase 4 Atorvastatin
12 Opioid-potentiated Volative Anaesthetic Vs. Remifentanil And Propofol During Abdominal Aortic Aneurysm Surgery Completed NCT00538421 Phase 4 Propofol;Sevoflurane
13 CUstodiol Versus RInger: whaT Is the Best Agent? Completed NCT02327611 Phase 4 Custodiol;Enriched Ringer's lactate solution
14 Prevalence of Abdominal Aortic Aneurysm in Patients Undergoing Coronary Angiography Completed NCT01239225 Phase 4
15 Epidural Versus Wound Infusion Plus Morphine Bolus in Open Abdominal Aortic Aneurysm Repair Completed NCT02677532 Phase 4 Paracetamol;Levobupivacaine wound infiltration;Levobupivacaine epidural bolus;Sufentanil epidural bolus;Morphine;Levobupivacaine plus sufentanil epidural infusion;Levobupivacaine wound infusion
16 Thoracoabdominal Arortic CTA Study Completed NCT02291718 Phase 4 Isovue
17 TAP-Block in Abdominal Aortic Surgery Completed NCT03657979 Phase 4 Ropivacaine;Placebo
18 Fibrinogen as an Alternative to FFP in Aortic Surgery. Completed NCT00994045 Phase 4
19 Vasculopathic Injury and Plasma as Endothelial Rescue - OCTAplas Trial (EudraCT no. 2014-000452-28) Completed NCT02253082 Phase 4 OctaplasLG®
20 Atorvastatin in Perioperative Vascular Surgery - Pilot Study Completed NCT00610545 Phase 4 Atorvastatin;Atorvastatin
21 A Controlled Trial of Effectiveness of a Backward Walking Program in Patients Recovering From Abdominal Aorta Surgery Completed NCT00819936 Phase 4
22 Study of Tomography of Nephrolithiasis Evaluation Completed NCT01451931 Phase 4
23 Randomized Trial of Pulsatile vs Non Pulsatile Perfusion on Short Term Changes in Kidney Function Using an Intra-Aortic Ballooon Pump During Cardioplegic Arrest in Patients Undergoing Myocardial Reperfusion Completed NCT00454428 Phase 4
24 OlmeSartan and Calcium Antagonists Randomized (OSCAR) Study Completed NCT00134160 Phase 4 Olmesartan medoxomil;Calcium channel blockers (amlodipine, azelnidipine)
25 Eplerenone in the Management of Abdominal Aortic Aneurysms Recruiting NCT02345590 Phase 4 Eplerenone
26 Predictors of AAA Expansion and/or Rupture Recruiting NCT03231397 Phase 4 Assess AAA rupture risk by PET-CTA scans;18F-fludeoxyglucose (FDG)
27 Randomized Preventive Vascular Screening Trial of 65-74 Year Old Men in the Central Region of Denmark Recruiting NCT00662480 Phase 4
28 Bloodtranfusions After Aortic Surgery Recruiting NCT02299947 Phase 4 Haemocomplettan P;Placebo
29 Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Randomized Clinical Trial Recruiting NCT02678728 Phase 4 Dexmedetomidine;normal saline
30 Pilot Study of of Renal Arterial Sympathetic Denervation by Cryotherapy Active, not recruiting NCT02345603 Phase 4
31 Tranexamic Acid in Major Vascular Surgery Active, not recruiting NCT02335359 Phase 4 tranexamic acid diluted in 100 ml of saline solution (loading dose);tranexamic acid undiluted (continous infusion);Placebo
32 Post-Market Study to Assess Outcomes of Patients Treated With AFX System Compared to Other EVAR Devices Enrolling by invitation NCT02407457 Phase 4
33 Comparison of Surveillance Versus Aortic Endografting for Small Aneurysm Repair Terminated NCT00118573 Phase 4
34 Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic Aneurysms Terminated NCT00409344 Phase 4 Dexmedetomidine
35 Long-term Benefit of Aortic Stent-graft in Patients With Distal Aortic Dissection Terminated NCT01354119 Phase 4
36 A Safety and Efficacy Study of Blood Pressure Control in Acute Aortic Emergencies - A Pilot Study (PROMPT) Terminated NCT01033370 Phase 4 clevidipine.
37 ATLANTIS:Extensive Type A Dissections and Thoracic/ Thoraco-Abdominal Aneurysms Repair With LupiAe Hybrid TechNique Withdrawn NCT01107366 Phase 4
38 NExT ERA: National Expertise Based Trial of Elective Repair of Abdominal Aortic Aneurysms: A Pilot Study Unknown status NCT00358085 Phase 3
39 34mm Cuff Study for Endovascular Repair of Abdominal Aortic Aneurysms Unknown status NCT00706394 Phase 2, Phase 3
40 Magnetic Resonance Imaging of Aortic Aneurysm Instability Unknown status NCT00794092 Phase 2, Phase 3 Sinerem administration
41 Efficacy of the Ultrasound-guided Transversus Abdominis Plane Block in Open Aortic Abdominal Aneurysm Repair Surgery Unknown status NCT02292667 Phase 3 PCA with Chlorhydrate of Morphine;Acetaminophen
42 Study of Aortic Root Reimplantation Procedure Unknown status NCT01787604 Phase 3
43 The Use of Nesiritide in Thoracic Aneurysm Repair to Prevent Acute Renal Failure Unknown status NCT00110201 Phase 3 Nesiritide
44 Clinical Evaluation of a Modular Extracorporeal Circulation Circuit Unknown status NCT02000544 Phase 3
45 Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) Trial of Cardiovascular Events in High-Risk Hypertensive Patients Unknown status NCT00125463 Phase 3 Candesartan cilexetil
46 Study of the Endovascular QUANTUM LPâ„¢ Stent Graft System in Abdominal Aortic Aneurysms (AAA) Completed NCT00233688 Phase 3
47 Curcumin to Prevent Complications After Elective Abdominal Aortic Aneurysm (AAA) Repair Completed NCT01225094 Phase 2, Phase 3 curcumin
48 Prevention of Colon Ischemia During Aortic Aneurysm (AAA) Repair Completed NCT00671203 Phase 3
49 ARBITER-II: Aorfixâ„¢ Bifurcated Safety and Performance Trial: Phase II, Angulated Vessels Completed NCT00442065 Phase 2, Phase 3
50 Melatonin and Cardiac Outcome After Major Surgery Completed NCT00315926 Phase 2, Phase 3 Melatonin;Placebo

Search NIH Clinical Center for Aortic Aneurysm

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: aortic aneurysm

Sources

Genetic Tests for Aortic Aneurysm

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Genetic tests related to Aortic Aneurysm:

# Genetic test Affiliating Genes
1 Aortic Aneurysm 30
Sources

Anatomical Context for Aortic Aneurysm

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MalaCards organs/tissues related to Aortic Aneurysm:

42
Kidney, Heart, Testes, Spinal Cord, Lung, Smooth Muscle, Endothelial
Sources

Publications for Aortic Aneurysm

About this section

Articles related to Aortic Aneurysm:

(show top 50) (show all 6650)
# Title Authors Year
1
Surgical Repair of a 13-cm Infrarenal Abdominal Aortic Aneurysm with Aortocaval Fistula in a 63-Year-Old Tuba Player. ( 30833836 )
2019
2
Correction to: Computational study on hemodynamic changes in patient-specific proximal neck angulation of abdominal aortic aneurysm with time-varying velocity. ( 30835076 )
2019
3
Paraplegia prevention in aortic aneurysm repair by thoracoabdominal staging with 'minimally invasive staged segmental artery coil embolisation' (MIS²ACE): trial protocol for a randomised controlled multicentre trial. ( 30837256 )
2019
4
Identification of a novel class of RIP1/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models. ( 30842407 )
2019
5
A novel SMAD6 variant in a patient with severely calcified bicuspid aortic valve and thoracic aortic aneurysm. ( 30848080 )
2019
6
Risk factors and outcomes for bowel ischemia after open and endovascular abdominal aortic aneurysm repair. ( 30850284 )
2019
7
Washington State abdominal aortic aneurysm-related mortality shows a steady decline between 1996 and 2016. ( 30850292 )
2019
8
Endosuture aneurysm repair in patients treated with Endurant II/IIs in conjunction with Heli-FX EndoAnchor implants for short-neck abdominal aortic aneurysm. ( 30850297 )
2019
9
Mas receptor deficiency augments angiotensin II-induced atherosclerosis and aortic aneurysm ruptures in hypercholesterolemic male mice. ( 30850299 )
2019
10
Endovascular exclusion for giant abdominal aortic aneurysm. ( 30850348 )
2019
11
Increasing surgeon volume correlates with patient survival following open abdominal aortic aneurysm repair. ( 30852040 )
2019
12
Abdominal Aortic Aneurysm Screening Is Safe yet Lacks Effectiveness. ( 30855994 )
2019
13
c‑Jun/Ap‑1 is upregulated in an Ang II‑induced abdominal aortic aneurysm formation model and mediates Chop expression in mouse aortic smooth muscle cells. ( 30864718 )
2019
14
Outcomes after endovascular repair of abdominal aortic aneurysm involving the renovisceral arteries: A multi-center follow-up study. ( 30871441 )
2019
15
Improvement in the Assessment of Aortic Valve and Aortic Aneurysm Repair by 3-Dimensional Echocardiography. ( 30878428 )
2019
16
Aortopulmonary fistula secondary to giant ascending aortic aneurysm recognized by computed tomography. ( 30882191 )
2019
17
Meta-analysis of long-term survival after elective endovascular or open repair of abdominal aortic aneurysm. ( 30883709 )
2019
18
Emphysema. ( 30885079 )
2019
19
Endovascular repair of an abdominal aortic aneurysm using bifurcated stent-graft in a patient with bilateral external iliac artery occlusion. ( 30889166 )
2019
20
CT and 3D-ultrasound registration for spatial comparison of post-EVAR abdominal aortic aneurysm measurements: A cross-sectional study. ( 30889540 )
2019
21
Aorto-ureteric fistula post endovascular stent graft management of ruptured abdominal aortic aneurysm: a case report. ( 30891867 )
2019
22
Association of Life's Simple 7 with reduced clinically manifest abdominal aortic aneurysm: The ARIC study. ( 30898044 )
2019
23
Associations of nutritional status and muscle size with mortality after open aortic aneurysm repair. ( 30898367 )
2019
24
Commentary: Pay me now or pay me later: Acute aortic dissection concomitant with a giant abdominal aortic aneurysm. ( 30902472 )
2019
25
Gene expression in patients with abdominal aortic aneurysm - more than immunological mechanisms involved. ( 30904002 )
2019
26
Rapamycin attenuates a murine model of thoracic aortic aneurysm by downregulating the miR-126-3p mediated activation of MAPK/ERK signalling pathway. ( 30904162 )
2019
27
Spinal cord deficit after 1114 extent II open thoracoabdominal aortic aneurysm repairs. ( 30904252 )
2019
28
Coexistence of spontaneous coronary artery dissection and ascending aortic aneurysm. ( 30904405 )
2019
29
Accuracy of the ClearSightâ„¢ system in patients undergoing abdominal aortic aneurysm surgery. ( 30904953 )
2019
30
The impact of randomized trial results on abdominal aortic aneurysm repair rates from 2003 to 2016: A population-based time-series analysis. ( 30907272 )
2019
31
Erratum: "Abdominal Aortic Aneurysm Endovascular Repair: Profiling Postimplantation Morphometry and Hemodynamics With Image-Based Computational Fluid Dynamics" [ASME J. Biomech. Eng., 2018, 140(11), p. 111003; DOI: 10.1115/1.4040337]. ( 30907410 )
2019
32
Impact of Polar Renal Artery Coverage on Early Renal Function after Chimney Endovascular Aortic Aneurysm Repair. ( 30910175 )
2019
33
Outcome After Endovascular Repair of Ruptured Descending Thoracic Aortic Aneurysm: A National Multicentre Study. ( 30910493 )
2019
34
Renal Vein Thrombosis After Open Repair of Abdominal Aortic Aneurysm Successfully Treated by Direct Oral Anticoagulants. ( 30913995 )
2019
35
The long-term outcomes of open and endovascular repair for abdominal aortic aneurysm: A meta-analysis. ( 30914154 )
2019
36
Chronic Q Fever with Vascular Involvement: Progressive Abdominal Pain in a Patient with Aortic Aneurysm Repair in the United States. ( 30915246 )
2019
37
Transcaval aortic valve implantation through a partially thrombosed infrarenal aortic aneurysm. ( 30916333 )
2019
38
Management of abdominal aortic aneurysm and concomitant malignant disease. ( 30916530 )
2019
39
Effect of Cyclic Stretch on Vascular Endothelial Cells and Abdominal Aortic Aneurysm (AAA): Role in the Inflammatory Response. ( 30642067 )
2019
40
Ablation and Inhibition of the Immunoproteasome Catalytic Subunit LMP7 Attenuate Experimental Abdominal Aortic Aneurysm Formation in Mice. ( 30642978 )
2019
41
IL (Interleukin)-33 Suppresses Abdominal Aortic Aneurysm by Enhancing Regulatory T-Cell Expansion and Activity. ( 30651000 )
2019
42
Screening Program of Abdominal Aortic Aneurysm. ( 30654619 )
2019
43
Interleukin-6 Receptor Signalling and Abdominal Aortic Aneurysm Growth Rates. ( 30657332 )
2019
44
A genetic risk score for hypertension is associated with risk of thoracic aortic aneurysm. ( 30659280 )
2019
45
Predictors of perioperative morbidity and mortality in open abdominal aortic aneurysm repair. ( 30660323 )
2019
46
Deployment of stent graft in an excessively higher position above the renal artery induces a flow channel to the aneurysm in chimney endovascular aortic aneurysm repair: an in vitro study. ( 30663032 )
2019
47
Rescue of proximal failure of endovascular abdominal aortic aneurysm repair with standard and fenestrated grafts. ( 30665286 )
2019
48
The Cattell-Braasch maneuver might be a good option for a huge abdominal aortic aneurysm. ( 30671564 )
2019
49
Left colic artery aneurysm rupture after stent placement for abdominal aortic aneurysm associated with neurofibromatosis type 1. ( 30673931 )
2019
50
Aortic Aneurysm Is Not a Rapidly Expanding Balloon. ( 30678770 )
2019
Sources

Variations for Aortic Aneurysm

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ClinVar genetic disease variations for Aortic Aneurysm:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 COL3A1 NM_000090.3(COL3A1): c.505C> T (p.Leu169Phe) single nucleotide variant Conflicting interpretations of pathogenicity rs111391222 GRCh37 Chromosome 2, 189851842: 189851842
2 COL3A1 NM_000090.3(COL3A1): c.505C> T (p.Leu169Phe) single nucleotide variant Conflicting interpretations of pathogenicity rs111391222 GRCh38 Chromosome 2, 188987116: 188987116
3 MYH11 NM_001040113.1(MYH11): c.4963C> T (p.Arg1655Cys) single nucleotide variant Uncertain significance rs369409348 GRCh37 Chromosome 16, 15814019: 15814019
4 MYH11 NM_001040113.1(MYH11): c.4963C> T (p.Arg1655Cys) single nucleotide variant Uncertain significance rs369409348 GRCh38 Chromosome 16, 15720162: 15720162
5 FBN1 NM_000138.4(FBN1): c.7754T> C (p.Ile2585Thr) single nucleotide variant Pathogenic/Likely pathogenic rs727503054 GRCh37 Chromosome 15, 48712949: 48712949
6 FBN1 NM_000138.4(FBN1): c.7754T> C (p.Ile2585Thr) single nucleotide variant Pathogenic/Likely pathogenic rs727503054 GRCh38 Chromosome 15, 48420752: 48420752
7 TGFB2 NM_001135599.3(TGFB2): c.440C> T (p.Pro147Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs149533093 GRCh37 Chromosome 1, 218578520: 218578520
8 TGFB2 NM_001135599.3(TGFB2): c.440C> T (p.Pro147Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs149533093 GRCh38 Chromosome 1, 218405178: 218405178
Sources

Expression for Aortic Aneurysm

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Search GEO for disease gene expression data for Aortic Aneurysm.
Sources

Pathways for Aortic Aneurysm

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Pathways related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 65
Show member pathways
 13.72 ACTA2 COL3A1 EFEMP2 ELN FBN1 FBN2
2
PAK Pathway 65
Show member pathways
 13.2 ACTA2 MYH11 MYLK NOTCH1 SLC2A10 SMAD3
3
Integrin Pathway 65
Show member pathways
 13.14 ACTA2 COL3A1 EFEMP2 ELN FBN1 FBN2
4
Circadian entrainment 38
Show member pathways
 13.01 ACTA2 COL3A1 PRKG1 SMAD3 TGFBR1 TGFBR2
5
Phospholipase-C Pathway 65
Show member pathways
 12.95 ACTA2 COL3A1 EFEMP2 ELN FBN1 FBN2
6
Sertoli-Sertoli Cell Junction Dynamics 65
Show member pathways
 12.87 ACTA2 MYH11 PRKG1 TGFB2 TGFBR1 TGFBR2
7
NFAT and Cardiac Hypertrophy 65
Show member pathways
 12.83 ACTA2 MYLK TGFB2 TGFBR1 TGFBR2
8
Pathways in cancer 38
12.8 NOTCH1 SMAD3 TGFB2 TGFBR1 TGFBR2
9
Gastric cancer 38
Show member pathways
 12.73 NOTCH1 SMAD3 TGFB2 TGFBR1 TGFBR2
10
Th17 cell differentiation 38
Show member pathways
 12.55 NOTCH1 SMAD3 TGFB2 TGFBR1 TGFBR2
11
Degradation of the extracellular matrix 67
Show member pathways
 12.46 BGN COL3A1 EFEMP2 ELN FBN1 FBN2
12
Human Embryonic Stem Cell Pluripotency 65
Show member pathways
 12.44 SMAD3 TGFB2 TGFBR1 TGFBR2
13
Human T-cell leukemia virus 1 infection 38
12.32 SMAD3 TGFB2 TGFBR1 TGFBR2
14
Wnt / Hedgehog / Notch 4
12.22 NOTCH1 SMAD3 TGFB2 TGFBR1
15
Cell cycle Role of SCF complex in cell cycle regulation 23
Show member pathways
 12.2 SMAD3 TGFB2 TGFBR1 TGFBR2
16
Colorectal Cancer Metastasis 65
12.16 SMAD3 TGFB2 TGFBR1 TGFBR2
17
Cellular senescence (KEGG) 38
12.14 SMAD3 TGFB2 TGFBR1 TGFBR2
18
Hippo signaling pathway 38
12.11 SMAD3 TGFB2 TGFBR1 TGFBR2
19
FoxO signaling pathway 38
Show member pathways
 12.05 SMAD3 TGFB2 TGFBR1 TGFBR2
20
Apelin signaling pathway 38
12.04 ACTA2 MYLK SMAD3 TGFBR1
21
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 12.03 ACTA2 COL3A1 EFEMP2 ELN FBN1 FBN2
22
Th1 Differentiation Pathway 66
Show member pathways
 12 SMAD3 TGFB2 TGFBR1 TGFBR2
23
SMAD Signaling Network 65
12 ACTA2 SMAD3 TGFB2 TGFBR1 TGFBR2
24
TGF-beta Signaling Pathways 66
11.84 SMAD3 TGFB2 TGFBR1 TGFBR2
25
Cytokine production by Th17 cells in CF (Mouse model) 23
Show member pathways
 11.83 SMAD3 TGFBR1 TGFBR2
26
Angiogenesis (CST) 4
11.81 NOTCH1 TGFB2 TGFBR1
27
AGE-RAGE signaling pathway in diabetic complications 38
11.8 COL3A1 SMAD3 TGFB2 TGFBR1 TGFBR2
28
TGF-beta signaling pathway (KEGG) 38
11.79 SMAD3 TGFB2 TGFBR1 TGFBR2
29
Adherens junction 38
11.71 SMAD3 TGFBR1 TGFBR2
30
Development_TGF-beta receptor signaling 23
11.71 SMAD3 TGFBR1 TGFBR2
31
TGF-beta receptor signaling activates SMADs 67
Show member pathways
 11.69 SMAD3 TGFBR1 TGFBR2
32
Transcription_P53 signaling pathway 23
11.64 ACTA2 SMAD3 TGFB2 TGFBR1 TGFBR2
33
TGF-beta Receptor Signaling (WikiPathways) 1
11.6 SMAD3 TGFBR1 TGFBR2
34
IL-2 Gene Expression in Activated and Quiescent T-Cells 65
Show member pathways
 11.57 SMAD3 TGFB2 TGFBR1 TGFBR2
35
TGF-beta receptor signaling (Pathway Interaction Database) 1
11.53 SMAD3 TGFBR1 TGFBR2
36
Cell adhesion_Plasmin signaling 23
11.51 TGFB2 TGFBR1 TGFBR2
37
Microglia Activation During Neuroinflammation: Steady-State Microglia 66
11.46 TGFB2 TGFBR1 TGFBR2
38
G-protein signaling_Cross-talk between Ras-family GTPases 23
11.35 ACTA2 MYLK TGFB2 TGFBR1 TGFBR2
39
Smooth Muscle Contraction 67
11.32 ACTA2 MYH11 MYLK
40
Extracellular vesicle-mediated signaling in recipient cells 1
11.15 SMAD3 TGFB2 TGFBR1 TGFBR2
41
NTHi-Induced Signaling 65
11.05 SMAD3 TGFBR1 TGFBR2
42
Elastic fibre formation 67
Show member pathways
 11.03 EFEMP2 ELN FBN1 FBN2 LOX MFAP5
43
G-protein signaling_Rap2B regulation pathway 23
10.94 COL3A1 EFEMP2 ELN FBN1 FBN2 MYLK
44
Hypothesized Pathways in Pathogenesis of Cardiovascular Disease 1
10.75 FBN1 FBN2 SMAD3 TGFBR1 TGFBR2
Sources

GO Terms for Aortic Aneurysm

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Cellular components related to Aortic Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.96 BGN COL3A1 EFEMP2 ELN FBN1 FBN2
2 receptor complex GO:0043235 9.62 NOTCH1 SMAD3 TGFBR1 TGFBR2
3 extracellular matrix GO:0031012 9.5 BGN COL3A1 ELN FBN1 FBN2 LOX
4 microfibril GO:0001527 9.33 FBN1 FBN2 MFAP5
5 collagen-containing extracellular matrix GO:0062023 9.17 BGN COL3A1 ELN FBN1 FBN2 MFAP5

Biological processes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 49)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.95 CDKN2B-AS1 MYLK NOTCH1 SMAD3 TGFBR1
2 in utero embryonic development GO:0001701 9.94 NOTCH1 SMAD3 TGFBR1 TGFBR2
3 kidney development GO:0001822 9.88 FBN1 TGFB2 TGFBR1
4 muscle contraction GO:0006936 9.88 ACTA2 MYH11 MYLK
5 cell cycle arrest GO:0007050 9.88 NOTCH1 SMAD3 TGFB2 TGFBR1
6 skeletal system development GO:0001501 9.88 COL3A1 FBN1 SMAD3 TGFB2 TGFBR1
7 lung development GO:0030324 9.86 LOX NOTCH1 TGFBR2
8 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.83 SMAD3 TGFBR1 TGFBR2
9 cellular response to transforming growth factor beta stimulus GO:0071560 9.81 FBN1 SMAD3 TGFBR1
10 heart looping GO:0001947 9.8 NOTCH1 SMAD3 TGFBR2
11 embryonic limb morphogenesis GO:0030326 9.8 FBN2 NOTCH1 TGFB2
12 extracellular matrix organization GO:0030198 9.8 BGN COL3A1 ELN FBN1 FBN2 MFAP5
13 outflow tract morphogenesis GO:0003151 9.79 ELN NOTCH1 TGFBR2
14 transforming growth factor beta receptor signaling pathway GO:0007179 9.77 COL3A1 SMAD3 TGFB2 TGFBR1 TGFBR2
15 epithelial to mesenchymal transition GO:0001837 9.74 NOTCH1 TGFB2 TGFBR1
16 embryonic cranial skeleton morphogenesis GO:0048701 9.73 SMAD3 TGFBR1 TGFBR2
17 collagen fibril organization GO:0030199 9.73 COL3A1 LOX TGFB2 TGFBR1
18 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.71 TGFBR1 TGFBR2
19 ventricular trabecula myocardium morphogenesis GO:0003222 9.71 NOTCH1 TGFB2 TGFBR1
20 ventricular septum morphogenesis GO:0060412 9.71 NOTCH1 TGFB2 TGFBR1 TGFBR2
21 smooth muscle contraction GO:0006939 9.7 MYH11 MYLK
22 activin receptor signaling pathway GO:0032924 9.7 SMAD3 TGFBR1
23 cardiac epithelial to mesenchymal transition GO:0060317 9.7 NOTCH1 TGFB2 TGFBR1
24 heart development GO:0007507 9.7 COL3A1 FBN1 LOX NOTCH1 TGFB2 TGFBR1
25 endocardial cushion morphogenesis GO:0003203 9.69 NOTCH1 TGFB2
26 regulation of epithelial cell proliferation GO:0050678 9.69 NOTCH1 SMAD3
27 pathway-restricted SMAD protein phosphorylation GO:0060389 9.69 TGFB2 TGFBR1 TGFBR2
28 cardiac muscle cell proliferation GO:0060038 9.68 NOTCH1 TGFB2
29 negative regulation of immune response GO:0050777 9.68 COL3A1 TGFB2
30 pulmonary valve morphogenesis GO:0003184 9.68 NOTCH1 TGFB2
31 secondary palate development GO:0062009 9.68 TGFB2 TGFBR2
32 supramolecular fiber organization GO:0097435 9.67 COL3A1 MFAP5
33 cardiac left ventricle morphogenesis GO:0003214 9.67 NOTCH1 TGFBR2
34 membranous septum morphogenesis GO:0003149 9.67 TGFB2 TGFBR2
35 atrioventricular valve morphogenesis GO:0003181 9.67 NOTCH1 TGFB2 TGFBR2
36 response to cholesterol GO:0070723 9.66 TGFBR1 TGFBR2
37 somatic stem cell division GO:0048103 9.66 NOTCH1 TGFB2
38 coronary artery morphogenesis GO:0060982 9.65 NOTCH1 TGFBR1
39 embryonic eye morphogenesis GO:0048048 9.65 FBN1 FBN2
40 elastic fiber assembly GO:0048251 9.63 EFEMP2 LOX MYH11
41 aorta smooth muscle tissue morphogenesis GO:0060414 9.61 COL3A1 MYLK
42 endocardial cushion fusion GO:0003274 9.61 TGFB2 TGFBR2
43 glomerular mesangial cell development GO:0072144 9.6 ACTA2 NOTCH1
44 regulation of transforming growth factor beta2 production GO:0032909 9.59 SMAD3 TGFB2
45 sequestering of TGFbeta in extracellular matrix GO:0035583 9.58 FBN1 FBN2
46 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.43 TGFB2 TGFBR1 TGFBR2
47 positive regulation of epithelial to mesenchymal transition GO:0010718 9.35 NOTCH1 SMAD3 TGFB2 TGFBR1 TGFBR2
48 wound healing GO:0042060 9.1 COL3A1 LOX SMAD3 TGFB2 TGFBR1 TGFBR2
49 positive regulation of gene expression GO:0010628 10.04 ACTA2 CDKN2B-AS1 NOTCH1 SMAD3 TGFBR1

Molecular functions related to Aortic Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SMAD binding GO:0046332 9.46 COL3A1 SMAD3 TGFBR1 TGFBR2
2 transforming growth factor beta-activated receptor activity GO:0005024 9.37 TGFBR1 TGFBR2
3 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.32 TGFBR1 TGFBR2
4 type II transforming growth factor beta receptor binding GO:0005114 9.26 TGFB2 TGFBR1
5 extracellular matrix structural constituent GO:0005201 9.17 BGN COL3A1 EFEMP2 ELN FBN1 FBN2
6 extracellular matrix constituent conferring elasticity GO:0030023 9.13 ELN FBN1 FBN2
Sources

Sources for Aortic Aneurysm

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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