MCID: ART016
MIFTS: 68

Aortic Aneurysm

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Aortic Aneurysm

MalaCards integrated aliases for Aortic Aneurysm:

Name: Aortic Aneurysm 12 73 29 6 42 3 44 15 17 70
Aortic Rupture 44 17 70
Thoracoabdominal Aortic Aneurysm, Ruptured 70 32
Aortic Aneurysm Without Mention of Rupture Nos 70
Ruptured Abdominal Aortic Aneurysm 70
Ruptured Thoracic Aortic Aneurysm 70
Aortic Aneurysm, Ruptured 70
Ruptured Aortic Aneurysm 12
Aortic Aneurysms 15

Classifications:



External Ids:

Disease Ontology 12 DOID:3627
UMLS 70 C0003486 C0003496 C0265010 more

Summaries for Aortic Aneurysm

MedlinePlus : 42 An aneurysm is a bulge or "ballooning" in the wall of an artery. Arteries are blood vessels that carry oxygen-rich blood from the heart to other parts of the body. If an aneurysm grows large, it can burst and cause dangerous bleeding or even death. Most aneurysms are in the aorta, the main artery that runs from the heart through the chest and abdomen. There are two types of aortic aneurysm: Thoracic aortic aneurysms (TAA) - these occur in the part of the aorta running through the chest Abdominal aortic aneurysms (AAA) - these occur in the part of the aorta running through the abdomen Most aneurysms are found during tests done for other reasons. Some people are at high risk for aneurysms. It is important for them to get screening, because aneurysms can develop and become large before causing any symptoms. Screening is recommended for people between the ages of 65 and 75 if they have a family history, or if they are men who have smoked. Doctors use imaging tests to find aneurysms. Medicines and surgery are the two main treatments. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Aortic Aneurysm, also known as aortic rupture, is related to aortic aneurysm, familial abdominal, 1 and aortic aneurysm, familial thoracic 9, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Aortic Aneurysm is FBN1 (Fibrillin 1), and among its related pathways/superpathways are ERK Signaling and PAK Pathway. The drugs Eplerenone and Acetazolamide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, smooth muscle and heart, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size.

CDC : 3 An aortic aneurysm is a balloon-like bulge in the aorta, the large artery that carries blood from the heart through the chest and torso. Aortic aneurysms work in two ways: • The force of blood pumping can split the layers of the artery wall, allowing blood to leak in between them. This process is called a dissection. • The aneurysm can burst completely, causing bleeding inside the body. This is called a rupture. • Dissections and ruptures are the cause of most deaths from aortic aneurysms.

Wikipedia : 73 An aortic aneurysm is an enlargement (dilatation) of the aorta to greater than 1.5 times normal size.... more...

Related Diseases for Aortic Aneurysm

Diseases related to Aortic Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 937)
# Related Disease Score Top Affiliating Genes
1 aortic aneurysm, familial abdominal, 1 33.1 TGFBR2 MYH11 LOX FBN1 ELN EFEMP2
2 aortic aneurysm, familial thoracic 9 33.1 MFAP5 LOX
3 loeys-dietz syndrome 2 32.9 TGFBR2 TGFBR1 MYH11 MFAP5 FBN1
4 aortic aneurysm, familial thoracic 6 32.9 TGFBR1 SMAD3 SLC2A10 MYLK MYH11 FBN1
5 aortic aneurysm, familial thoracic 4 32.7 TGFBR2 TGFBR1 TGFB2 SMAD3 SLC2A10 MYH11
6 loeys-dietz syndrome 1 32.6 TGFBR2 TGFBR1 TGFB2 SMAD3 SLC2A10 MYLK
7 aortic aneurysm, familial thoracic 2 32.5 SLC2A10 FBN2 FBN1 COL3A1 ACTA2
8 meester-loeys syndrome 32.4 SLC2A10 EFEMP2
9 familial abdominal aortic aneurysm 32.4 MYLK FBN1 ELN COL3A1
10 familial thoracic aortic aneurysm and aortic dissection 32.4 TGFBR2 TGFBR1 TGFB2 SMAD3 SLC2A10 PRKG1
11 loeys-dietz syndrome 5 32.1 TGFBR2 TGFBR1 TGFB2 SMAD3 FBN1
12 loeys-dietz syndrome 4 32.0 TGFBR2 TGFBR1 TGFB2 SMAD3 SLC2A10 FBN1
13 cutis laxa, autosomal recessive, type ib 32.0 FBN1 FBLN5 ELN EFEMP2
14 cutis laxa, autosomal dominant 1 31.9 TGFBR2 TGFBR1 SLC2A10 FBN1 FBLN5 ELN
15 autosomal recessive cutis laxa type i 31.9 SLC2A10 FBN1 FBLN5 ELN EFEMP2
16 marfan syndrome 31.9 TGFBR2 TGFBR1 TGFB2 NOTCH1 MYLK MYH11
17 patent ductus arteriosus 1 31.9 TGFBR2 TGFBR1 SLC2A10 NOTCH1 MYLK MYH11
18 loeys-dietz syndrome 31.7 TGFBR2 TGFBR1 TGFB2 SMAD3 SLC2A10 PRKG1
19 aortic aneurysm, familial thoracic 1 31.6 TGFBR2 TGFBR1 TGFB2 SMAD3 SLC2A10 PRKG1
20 loeys-dietz syndrome 3 31.6 TGFBR2 TGFBR1 TGFB2 SMAD3 SLC2A10 MYLK
21 aneurysm 31.4 TGFBR2 TGFBR1 TGFB2 SMAD3 SLC2A10 PRKG1
22 aortic valve insufficiency 31.3 TGFBR2 TGFBR1 MYH11 FBN2 FBN1 ELN
23 ehlers-danlos syndrome 31.3 TGFBR1 FBN1 ELN COL3A1
24 inguinal hernia 31.3 LOX FBN1 FBLN5 ELN
25 hemopericardium 31.2 FBN1 ELN
26 mitral valve insufficiency 31.0 MYH11 FBN1 ELN
27 lipoprotein quantitative trait locus 31.0 TGFBR2 TGFB2 SMAD3 NOTCH1 MYH11 FBN1
28 aortic disease 30.9 TGFBR2 TGFBR1 TGFB2 SMAD3 PRKG1 NOTCH1
29 pneumothorax 30.8 FBN1 FBLN5 ELN
30 aortic dissection 30.7 TGFBR2 TGFBR1 TGFB2 SMAD3 SLC2A10 PRKG1
31 tetralogy of fallot 30.7 NOTCH1 MYH11 FBN1 ELN
32 pulmonary hypertension 30.6 TGFBR2 TGFBR1 SMAD3 PRKG1 ACTA2
33 collagen disease 30.5 TGFBR2 TGFBR1 FBN1 ELN COL3A1
34 ventricular septal defect 30.5 TGFBR2 NOTCH1 FBN2
35 telangiectasis 30.5 TGFBR1 FBN1 ELN
36 supravalvular aortic stenosis 30.5 FBN1 FBLN5 ELN EFEMP2
37 pulmonary emphysema 30.5 LOX FBLN5 ELN
38 mitral valve disease 30.5 TGFB2 FBN1 ELN
39 exfoliation syndrome 30.5 LOX FBN1 ELN
40 moyamoya disease 1 30.5 MYLK MYH11 ELN ACTA2
41 intracranial aneurysm 30.4 TGFBR2 TGFBR1 TGFB2 LOX FBN2 ELN
42 cutis laxa 30.4 LOX FBN1 FBLN5 ELN EFEMP2
43 heritable thoracic aortic disease 30.4 TGFBR2 TGFBR1 TGFB2 SMAD3 PRKG1 MYLK
44 atrial heart septal defect 30.4 NOTCH1 FBN1 ELN
45 scoliosis 30.4 TGFBR2 TGFB2 SMAD3 LOX FBN2 FBN1
46 ehlers-danlos syndrome, vascular type 30.3 TGFB2 MYH11 FBN1 ELN COL3A1 ACTA2
47 pseudoxanthoma elasticum 30.3 MYH11 FBN1 ELN
48 hereditary hemorrhagic telangiectasia 30.3 TGFBR2 TGFBR1 TGFB2
49 weill-marchesani syndrome 30.3 FBN2 FBN1 ELN
50 brittle bone disorder 30.2 LOX FBN1 ELN COL3A1

Comorbidity relations with Aortic Aneurysm via Phenotypic Disease Network (PDN): (show all 13)


Acute Cystitis Acute Kidney Failure
Acute Vascular Insufficiency of Intestine Aortic Valve Disease 1
Cardiac Arrest Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Paralytic Ileus Peripheral Vascular Disease
Respiratory Failure

Graphical network of the top 20 diseases related to Aortic Aneurysm:



Diseases related to Aortic Aneurysm

Symptoms & Phenotypes for Aortic Aneurysm

UMLS symptoms related to Aortic Aneurysm:


angina pectoris; chest pain; edema

GenomeRNAi Phenotypes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00107-A-1 9.92 TGFBR2
2 Decreased viability GR00221-A-1 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
3 Decreased viability GR00221-A-2 9.92 COL3A1 PRKG1
4 Decreased viability GR00221-A-3 9.92 TGFBR2
5 Decreased viability GR00221-A-4 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
6 Decreased viability GR00249-S 9.92 MYLK TGFBR1 TGFBR2
7 Decreased viability GR00301-A 9.92 PRKG1
8 Decreased viability GR00402-S-2 9.92 TGFBR1 TGFBR2

MGI Mouse Phenotypes related to Aortic Aneurysm:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.47 ACTA2 COL3A1 EFEMP2 FBLN5 FBN1 FBN2
2 growth/size/body region MP:0005378 10.32 COL3A1 EFEMP2 FBLN5 FBN1 FBN2 LOX
3 cellular MP:0005384 10.3 COL3A1 EFEMP2 FBLN5 FBN1 FBN2 MYH11
4 homeostasis/metabolism MP:0005376 10.25 COL3A1 FBLN5 FBN1 FBN2 LOX MYH11
5 hematopoietic system MP:0005397 10.2 COL3A1 FBN1 LOX MFAP5 NOTCH1 PRKG1
6 immune system MP:0005387 10.18 COL3A1 FBN1 LOX MFAP5 MYLK NOTCH1
7 digestive/alimentary MP:0005381 10.15 COL3A1 MYH11 MYLK NOTCH1 PRKG1 SMAD3
8 mortality/aging MP:0010768 10.13 COL3A1 EFEMP2 FBN1 FBN2 LOX MYH11
9 craniofacial MP:0005382 10.11 FBLN5 FBN1 FBN2 LOX NOTCH1 SMAD3
10 integument MP:0010771 10.11 COL3A1 EFEMP2 FBLN5 FBN1 FBN2 LOX
11 muscle MP:0005369 10.1 ACTA2 COL3A1 EFEMP2 FBLN5 FBN1 FBN2
12 renal/urinary system MP:0005367 9.85 FBN1 FBN2 MYH11 MYLK NOTCH1 PRKG1
13 respiratory system MP:0005388 9.73 COL3A1 EFEMP2 FBLN5 FBN1 FBN2 LOX
14 skeleton MP:0005390 9.36 EFEMP2 FBN1 FBN2 LOX MFAP5 MYLK

Drugs & Therapeutics for Aortic Aneurysm

Drugs for Aortic Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 201)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Eplerenone Approved Phase 4 107724-20-9 150310 443872
2
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
3
Iodine Approved, Investigational Phase 4 7553-56-2 807
4
Remifentanil Approved Phase 4 132875-61-7 60815
5
Atenolol Approved Phase 4 29122-68-7 2249
6
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
7
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
8
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
9
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
10
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
11
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
12
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
13
Atorvastatin Approved Phase 4 134523-00-5 60823
14
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
15
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
16
Desflurane Approved Phase 4 57041-67-5 42113
17
Heparin Approved, Investigational Phase 4 9005-49-6 772 9812414
18
Iron Approved Phase 4 7439-89-6 23925 29936
19
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
20
Morphine Approved, Investigational Phase 4 57-27-2 5288826
21
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
22
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
23
Clevidipine Approved, Investigational Phase 4 167221-71-8
24
Tryptophan Approved, Nutraceutical, Withdrawn Phase 4 73-22-3 6305
25
Cadexomer iodine Experimental Phase 4 94820-09-4
26
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
27 Hormone Antagonists Phase 4
28 Mineralocorticoid Receptor Antagonists Phase 4
29 Mineralocorticoids Phase 4
30 diuretics Phase 4
31 Anticonvulsants Phase 4
32 Carbonic Anhydrase Inhibitors Phase 4
33 Pharmaceutical Solutions Phase 4
34 Adrenergic Antagonists Phase 4
35 Adrenergic beta-Antagonists Phase 4
36 Adrenergic beta-1 Receptor Antagonists Phase 4
37 Sympatholytics Phase 4
38 Methylprednisolone Acetate Phase 4
39 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
40 Anticholesteremic Agents Phase 4
41 Fluorodeoxyglucose F18 Phase 4
42 Antigen-Antibody Complex Phase 4
43 calcium heparin Phase 4
44 Platelet Aggregation Inhibitors Phase 4
45 Fibrinolytic Agents Phase 4
46 Anticoagulants Phase 4
47 Protamines Phase 4
48 Antirheumatic Agents Phase 4
49 Anti-Inflammatory Agents, Non-Steroidal Phase 4
50 Anti-Inflammatory Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 596)
# Name Status NCT ID Phase Drugs
1 Eplerenone in the Management of Abdominal Aortic Aneurysms: A Proof-Of-Concept Randomised Controlled Trial Unknown status NCT02345590 Phase 4 Eplerenone
2 Prophylactic Mesh Implantation After Abdominal Aortic Aneurysm Repair. A Prospective, Randomised, Controlled Study Unknown status NCT01353443 Phase 4
3 The Effect of Immunonutrition on Outcome and Postoperative Recovery in Patients Undergoing Elective Surgical Repair of a Thoraco (Abdominal) Aneurysm Aorta Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
4 Pilot Study of of Renal Arterial Sympathetic Denervation by Cryotherapy During Open Surgery for Aortic Aneurysm Unknown status NCT02345603 Phase 4
5 A Randomised Controlled Trial of the Effectiveness of Acetazolamide in Reducing Cerebrospinal Fluid Pressure for Patients Undergoing Thoracic-abdominal Aortic Repair Unknown status NCT01889498 Phase 4 Acetazolamide
6 CUstodiol Versus RInger: whaT Is the Best Agent? A Randomized Double Blind Trial. Completed NCT02327611 Phase 4 Custodiol;Enriched Ringer's lactate solution
7 A Clinical Evaluation of the GORE EXCLUDER® Bifurcated Endoprosthesis - Low Permeability in the Primary Treatment of Infrarenal Abdominal Aortic Aneurysms Completed NCT00593814 Phase 4
8 TALENT Endoluminal Stent Graft System for the Treatment of Abdominal Aortic Aneurysms Completed NCT00803075 Phase 4
9 Study of the Effectiveness of Telmisartan in Slowing the Progression of Abdominal Aortic Aneurysms Completed NCT01683084 Phase 4 Telmisartan;Placebo
10 Endovascular Treatment of Thoracic Aortic Aneurysms Using the TALENT Stent Graft System Completed NCT00802984 Phase 4
11 CSP #498 - Open Versus Endovascular Repair (OVER) Trial for Abdominal Aortic Aneurysms Completed NCT00094575 Phase 4
12 Randomised Controlled Trial of Effect of Pre-operative Statin Use on Matrix Metalloproteinases (MMP) & Tissue Inhibitors of Matrix Metalloproteinases (TIMP) in Abdominal Aortic Aneurysm (AAA). Completed NCT01062802 Phase 4 Atorvastatin
13 Opioid-potentiated Volative Anaesthetic(Sevoflurane)Compared to Remifentanil and Propofol During Abdominal Aortic Aneurysm Surgery Completed NCT00538421 Phase 4 Propofol;Sevoflurane
14 Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial) Completed NCT01904981 Phase 4 Beta-blocker-Atenolol 50mg, PO(peroral), Once daily;Angiotensin receptor blocker-Valsartan 80mg, PO(peroral), Once daily
15 Noninvasive Assessment of Abdominal Aortic Aneurysm (AAA) Wall Structural Integrity and Inflammation as Predictors of Expansion and/or Rupture Completed NCT03231397 Phase 4 Assess AAA rupture risk by PET-CTA scans;18F-fludeoxyglucose (FDG)
16 Transversus Abdominis Plane (TAP) Block in Open Abdominal Aortic Surgery : Randomized Controlled Doubled-blind Trial Comparing Ropivacaine 0.2% Versus Placebo Completed NCT03657979 Phase 4 Ropivacaine;Placebo
17 Effects of OctaplasLG® on Endothelial Integrity in Patients Undergoing Emergency Surgery for Thoracic Aortic Dissections - a Randomized, Controlled, Single-blinded Investigator-initiated Pilot Trial Completed NCT02253082 Phase 4 OctaplasLG®
18 Comparison of High Iodine Concentration Contrast Material (Isovue 370) vs Standard Protocol (Isovue 300) in Thoracoabdominal Aortic Computed Tomographic Angiography (CTA) for Radiation Dose Reduction Completed NCT02291718 Phase 4 Isovue
19 Coagulopathy During Surgery for the Repair of Extent 4 Thoraco-Abdominal Aortic Aneurysms - Feasibility Study of the Use of Fibrinogen Concentrate by Infusion in Place of Fresh Frozen Plasma. Completed NCT00994045 Phase 4
20 Prevalence of Abdominal Aortic Aneurysm in Patients Undergoing Coronary Angiography Completed NCT01239225 Phase 4
21 Comparison of Intravenous Anesthetics and Volatile Anesthetics on Postoperative Cognitive Dysfunction of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities. Completed NCT02107170 Phase 4 Sevoflurane;Propofol;Remifentanil
22 Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Randomized Clinical Trial Completed NCT02678728 Phase 4 Dexmedetomidine;normal saline
23 Randomized Preventive Vascular Screening Trial of 65-74 Year Old Men in the Central Region of Denmark Recruiting NCT00662480 Phase 4
24 ACTION-1: ACT Guided Heparinization During Open Abdominal Aortic Aneurysm Repair, a Randomised Trial. Recruiting NCT04061798 Phase 4 ACT guided heparinization;5 000 IU of heparin
25 Fast-track in Endovascular Aortic Aneurysm Repair With Desflurane and Sevoflurane: a Randomized Clinical Trial Recruiting NCT03917186 Phase 4 Sevoflurane;Desflurane
26 A Phase IV Double-blind, Randomised, Parallel Group Comparison of the Efficacy and Safety of Preoperative Intravenous Ferric Carboxymaltose and Placebo in the Treatment of Patients Undergoing Elective or Urgent Cardiac Surgery Recruiting NCT03574311 Phase 4 Ferric carboxymaltose
27 Trial Investigating ESAR (EVAR Plus Heli-FX EndoAnchors) and FEVAR for the Treatment of Aortic Aneurysms With Short Infrarenal Aortic Neck Not yet recruiting NCT04503395 Phase 4
28 Randomized, Double-blind, Placebo-controlled Single-centre Clinical Trial Evaluating Efficacy and Safety of Intraoperative and Postoperative Continuous Lidocaine Infusion in High Cardiac Risk Vascular Surgery Suspended NCT04691726 Phase 4 lidocaine 10mg/ml;Placebo;Metamizole;Morphine
29 Phase 4 Study of Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic Aneurysms Terminated NCT00409344 Phase 4 Dexmedetomidine
30 Randomized Clinical Trial Comparing Surveillance and Selective Surgical Treatment for Abdominal Aortic Aneurysms Less Than 5.5 cm in Diameter Versus Early Endovascular Treatment Terminated NCT00118573 Phase 4
31 A Safety and Efficacy Study of Blood Pressure Control in Acute Aortic Emergencies - A Pilot Study (PROMPT) Terminated NCT01033370 Phase 4 clevidipine.
32 Long-term Benefit of Aortic Stent-graft in Patients With Distal Aortic Dissection Terminated NCT01354119 Phase 4
33 Comparison of a Single Dose Fibrinogen With Placebo and the Number of Blood Transfusions After Ascending Aorta Surgery (FIBTEG Study) Terminated NCT02299947 Phase 4 Haemocomplettan P;Placebo
34 Extensive Type A Dissections and Thoracic/ Thoraco-Abdominal Withdrawn NCT01107366 Phase 4
35 Prospective, Multicenter, Single Arm Phase II Study of the Powerlink 34mm Cuff for the Endovascular Repair of Abdominal Aortic Aneurysms Unknown status NCT00706394 Phase 2, Phase 3
36 Expertise Based Randomized Controlled Trial of Open Versus Endovascular Repair of Abdominal Aortic Aneurysms: A Pilot Study Unknown status NCT00358085 Phase 3
37 Efficacy of the Ultrasound-guidedTransversus Abdominis Plane (TAP) Block on Postoperative Pain Control in Open Aortic Abdominal Aneurysm Repair Surgery Unknown status NCT02292667 Phase 3 PCA with Chlorhydrate of Morphine;Acetaminophen
38 Magnetic Resonance Imaging of Aortic Aneurysm Instability Unknown status NCT00794092 Phase 2, Phase 3 Sinerem administration
39 Prophylactic Use of Nesiritide (Brain Natriuretic Peptide, BNP) for the Prevention of Acute Renal Failure in Thoracic Aortic Aneurysm Surgery Patients Unknown status NCT00110201 Phase 3 Nesiritide
40 The Hemostatic Potential of TDM-621 on Ascending Aortic Surgery Unknown status NCT03917862 Phase 2, Phase 3
41 The Effect of Tranexamic Acid in Ruptured Abdominal Aortic Aneurysms Completed NCT02125890 Phase 3 Tranexamic Acid
42 Endologix Powerlink Long-Term Follow-up Study Completed NCT00543270 Phase 2, Phase 3
43 A Prospective, Multicenter Study of the Cordis Endovascular QUANTUM LP™ Stent Graft System for the Treatment of Abdominal Aortic Aneurysms (AAA)-FORTRON Completed NCT00233688 Phase 3
44 Evaluation of the Medtronic Vascular Talent Thoracic Stent Graft System for the Treatment of Thoracic Aortic Aneurysms Completed NCT00604799 Phase 2, Phase 3
45 Curcumin to Prevent Perioperative Complications After Elective Abdominal Aortic Aneurysm Repair: a Randomized Controlled Trial Completed NCT01225094 Phase 2, Phase 3 curcumin
46 A Study to Assess the Acute Technical Success of Aorfix™ Stent Grafts in the Treatment of Abdominal Aortic and Aorto-Iliac Aneurysm Where a Significant Degree of Vessel Angulation Exists at the Neck of the Aneurysm Completed NCT00442065 Phase 2, Phase 3
47 Prevention of Colon Ischemia During Aortic Aneurysm (AAA) Repair Completed NCT00671203 Phase 3
48 Melatonin and Cardiac Morbidity After Elective Abdominal Aortic Aneurism Repair Completed NCT00315926 Phase 2, Phase 3 Melatonin;Placebo
49 A Clinical Study of the TAG Thoracic Endoprosthesis in the Treatment of Thoracic Aortic Diseases for Non-Surgical Candidates Under the Physician Sponsored IDE. Completed NCT00757003 Phase 3
50 Multicenter Randomized Controlled Trial of Loading Dose Statins for the Prevention of Cardiovascular Complications in High-Risk Non-Cardiac Surgery Completed NCT01543555 Phase 3 Atorvastatin;Placebo

Search NIH Clinical Center for Aortic Aneurysm

Inferred drug relations via UMLS 70 / NDF-RT 51 :


trimethaphan camsylate

Cochrane evidence based reviews: aortic aneurysm

Genetic Tests for Aortic Aneurysm

Genetic tests related to Aortic Aneurysm:

# Genetic test Affiliating Genes
1 Aortic Aneurysm 29

Anatomical Context for Aortic Aneurysm

MalaCards organs/tissues related to Aortic Aneurysm:

40
Spinal Cord, Smooth Muscle, Heart, Endothelial, Kidney, Neutrophil, Colon

Publications for Aortic Aneurysm

Articles related to Aortic Aneurysm:

(show top 50) (show all 26289)
# Title Authors PMID Year
1
Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms. 6
29689197 2018
2
Postoperative acute kidney injury and early and long-term mortality in acute aortic dissection patients: A meta-analysis. 42
33466119 2021
3
Non-O blood group is associated with lower risk of in-hospital mortality in non-surgically managed patients with type A aortic dissection. 42
33297966 2020
4
Hoarseness Due to Aortic Arch Aneurysms. 42
33306323 2020
5
Renovascular hypertension in Marfan syndrome. 54 61
9260256 1997
6
Oxidative stress in genetically triggered thoracic aortic aneurysm: role in pathogenesis and therapeutic opportunities. 61
33715602 2021
7
Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms. 61
33779682 2021
8
Aortic enlargement in chronic obstructive pulmonary disease (COPD) and emphysema: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD study. 61
33587941 2021
9
MiR-222-3p downregulation prompted the migration, invasion and recruitment of endothelial progenitor cells via ADIPOR1 expression increase-induced AMKP activation. 61
33428882 2021
10
Accuracy and Trending Ability of Cardiac Index Measured by the CNAP System in Patients Undergoing Abdominal Aortic Aneurysm Surgery. 61
32888805 2021
11
A novel intramural TGF β 1 hydrogel delivery method to decrease murine abdominal aortic aneurysm and rat aortic pseudoaneurysm formation and progression. 61
33545663 2021
12
Dexmedetomidine suppresses the development of abdominal aortic aneurysm by downregulating the mircoRNA‑21/PDCD 4 axis. 61
33786608 2021
13
LncRNA Xist induces arterial smooth muscle cell apoptosis in thoracic aortic aneurysm through miR-29b-3p/Eln pathway. 61
33761588 2021
14
A case of infectious thoracic aortic aneurysm after intravesical Bacillus Calmette-Guérin instillation therapy for a superficial bladder cancer. 61
33552915 2021
15
Sequential dilation strategy in stent therapy of the aortic coarctation: A single centre experience. 61
33548378 2021
16
Elevated levels of short-term blood pressure variability: A marker for ascending aortic dilatation in hypertensive patients. 61
33423545 2021
17
Technique-Based Evaluation of Clinical Outcomes and Aortic Remodelling Following TEVAR in Acute and Subacute Type B Aortic Dissection. 61
33388868 2021
18
Surgical outcomes of acute type A aortic dissection in patients undergoing cardiopulmonary resuscitation. 61
32008759 2021
19
Adventitial remodeling protects against aortic rupture following late smooth muscle-specific disruption of TGFβ signaling. 61
33508556 2021
20
Analysis of clinical outcomes of one-staged hybrid procedure without thoracotomy for aorta lesion involving distal aortic arch. 61
33522664 2021
21
Abdominal mycotic aortic aneurysm presenting as chronic constipation. 61
33388185 2021
22
Screening for Aortic Aneurysm: Further Evidence is Required to Clarify the Issue. 61
32981920 2021
23
Early Detection of Aortic Degeneration in a Mouse Model of Sporadic Aortic Aneurysm and Dissection Using Nanoparticle Contrast-Enhanced Computed Tomography. 61
33535789 2021
24
Evolution of fenestrated/branched endovascular aortic aneurysm repair complexity and outcomes at an organized center for the treatment of complex aortic disease. 61
33766243 2021
25
Is It Too Much to Request a Formal Neurology Consultation After Thoracic Endovascular Aortic Aneurysm Repair? 61
33023814 2021
26
TLR4 rs1927914 polymorphism contributes to serum TLR4 levels in patients with aortic aneurysm. 61
33516663 2021
27
Endovascular aortic repair in patients with challenging anatomies: the EXTREME study. 61
31793884 2021
28
Systematic review of plasma/packed red blood cell ratio on survival in ruptured abdominal aortic aneurysms. 61
33189763 2021
29
Cannabis use disorder and perioperative outcomes in vascular surgery. 61
32861869 2021
30
Post-EVAR Thrombus Density on Late Non-Contrast CT Scans Predicts Successful Aneurysm Exclusion. 61
33342395 2021
31
Towards enabling a cardiovascular digital twin for human systemic circulation using inverse analysis. 61
33064221 2021
32
Body Mass Index and Mortality From Aortic Aneurysm and Dissection. 61
32727971 2021
33
A Brush-Spin-Coating Method for Fabricating In Vitro Patient-Specific Vascular Models by Coupling 3D-Printing. 61
33263929 2021
34
Is there an immunogenomic difference between thoracic and abdominal aortic aneurysms? 61
33604952 2021
35
Utility of Noncontrast Magnetic Resonance Angiography for Aneurysm Follow-Up and Detection of Endoleaks after Endovascular Aortic Repair. 61
33543842 2021
36
A Nationwide Study Assessing Preventable Hospitalization Rate on Mortality After Major Cardiovascular Surgery. 61
32450214 2021
37
Infected aortic aneurysm caused by Streptococcus pyogenes: A case report. 61
33277175 2021
38
Incidence and natural history of isolated abdominal aortic dissection: A population-based assessment from 1995 to 2015. 61
32861864 2021
39
Clinical Characteristics of Aortic Aneurysm in MIMIC-III. 61
33798047 2021
40
Hybrid surgical and endovascular repair for anastomotic pseudoaneurysms after total arch replacement. 61
31663409 2021
41
Estimating aortic thoracic aneurysm rupture risk using tension-strain data in physiological pressure range: an in vitro study. 61
33389275 2021
42
Epigallocatechin gallate for medical management of the abdominal aortic aneurysm. 61
33766249 2021
43
Thirty-day outcomes of open abdominal aortic aneurysm repair by proximal clamp level in patients with normal and impaired renal function. 61
32890718 2021
44
Society for Vascular Surgery implementation of clinical practice guidelines for patients with an abdominal aortic aneurysm: Screening for an abdominal aortic aneurysm. 61
33610680 2021
45
Outcomes of abdominal aortic aneurysm repair among patients with rheumatoid arthritis. 61
32950628 2021
46
Increasing disparity between Society for Vascular Surgery guidelines for infrarenal abdominal aortic aneurysm repair and real-world practice. 61
32889077 2021
47
Resveratrol prevents acute renal injury in a model of ruptured abdominal aortic aneurysm. 61
32938235 2021
48
Systematic Review and Meta-Analysis of Interventions to Slow Progression of Abdominal Aortic Aneurysm in Mouse Models. 61
33567871 2021
49
There is no more wound complications with transabdominal open abdominal aortic aneurysm repair compared with the retroperitoneal approach. 61
33766252 2021
50
Coupled Hemodynamics and Oxygen Diffusion in Abdominal Aortic Aneurysm: A Computational Sensitivity Study. 61
33469846 2021

Variations for Aortic Aneurysm

ClinVar genetic disease variations for Aortic Aneurysm:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 ARIH1 NM_005744.5(ARIH1):c.43G>C (p.Glu15Gln) SNV association 996563 GRCh37: 15:72767023-72767023
GRCh38: 15:72474682-72474682
2 ARIH1 NM_005744.5(ARIH1):c.511C>T (p.Arg171Ter) SNV association 996698 GRCh37: 15:72837228-72837228
GRCh38: 15:72544887-72544887
3 ARIH1 NM_005744.5(ARIH1):c.131A>G (p.Glu44Gly) SNV association 996699 GRCh37: 15:72767111-72767111
GRCh38: 15:72474770-72474770
4 FBN1 NM_000138.5(FBN1):c.7754T>C (p.Ile2585Thr) SNV Pathogenic 163462 rs727503054 GRCh37: 15:48712949-48712949
GRCh38: 15:48420752-48420752
5 TGFB2 NM_003238.5(TGFB2):c.356C>T (p.Pro119Leu) SNV Uncertain significance 213840 rs149533093 GRCh37: 1:218578520-218578520
GRCh38: 1:218405178-218405178
6 COL3A1 NM_000090.3(COL3A1):c.505C>T (p.Leu169Phe) SNV Uncertain significance 161216 rs111391222 GRCh37: 2:189851842-189851842
GRCh38: 2:188987116-188987116
7 MYH11 , NDE1 NM_002474.3(MYH11):c.4942C>T (p.Arg1648Cys) SNV Uncertain significance 161318 rs369409348 GRCh37: 16:15814019-15814019
GRCh38: 16:15720162-15720162

Expression for Aortic Aneurysm

Search GEO for disease gene expression data for Aortic Aneurysm.

Pathways for Aortic Aneurysm

Pathways related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.54 TGFBR2 TGFBR1 TGFB2 SMAD3 NOTCH1 MYLK
2
Show member pathways
13.2 TGFBR2 TGFBR1 TGFB2 SMAD3 SLC2A10 NOTCH1
3
Show member pathways
13.2 TGFBR2 TGFBR1 TGFB2 MYLK MYH11 FBN2
4
Show member pathways
12.95 TGFBR1 TGFB2 FBN2 FBN1 ELN EFEMP2
5
Show member pathways
12.88 TGFBR2 TGFBR1 TGFB2 PRKG1 MYH11 ACTA2
6
Show member pathways
12.82 TGFBR2 TGFBR1 TGFB2 MYLK ACTA2
7 12.8 TGFBR2 TGFBR1 TGFB2 SMAD3 NOTCH1
8
Show member pathways
12.73 TGFBR2 TGFBR1 TGFB2 SMAD3 NOTCH1
9
Show member pathways
12.55 TGFBR2 TGFBR1 TGFB2 SMAD3 NOTCH1
10
Show member pathways
12.46 TGFB2 MFAP5 LOX FBN2 FBN1 FBLN5
11
Show member pathways
12.45 PRKG1 MYLK MYH11 ACTA2
12
Show member pathways
12.43 TGFBR2 TGFBR1 TGFB2 SMAD3
13 12.3 TGFBR2 TGFBR1 TGFB2 SMAD3
14 12.21 TGFBR1 TGFB2 SMAD3 NOTCH1
15 12.15 TGFBR2 TGFBR1 TGFB2 SMAD3
16 12.12 TGFBR2 TGFBR1 TGFB2 SMAD3
17 12.12 TGFBR2 TGFBR1 TGFB2 SMAD3
18
Show member pathways
12.04 TGFBR2 TGFBR1 TGFB2 SMAD3
19 12.04 TGFBR1 SMAD3 MYLK ACTA2
20
Show member pathways
11.91 TGFBR2 TGFBR1 TGFB2 SMAD3
21 11.85 TGFBR2 TGFBR1 TGFB2 SMAD3
22 11.83 TGFBR2 TGFBR1 TGFB2 SMAD3 COL3A1
23
Show member pathways
11.82 TGFBR2 TGFBR1 SMAD3
24
Show member pathways
11.82 TGFBR2 TGFBR1 TGFB2 SMAD3
25 11.8 TGFBR1 TGFB2 NOTCH1
26 11.78 TGFBR2 TGFBR1 TGFB2 SMAD3 FBN1
27
Show member pathways
11.72 TGFBR2 TGFBR1 SMAD3 LOX
28 11.7 TGFBR2 TGFBR1 SMAD3
29 11.69 TGFBR2 TGFBR1 SMAD3
30
Show member pathways
11.68 TGFBR2 TGFBR1 SMAD3
31 11.64 TGFBR2 TGFBR1 TGFB2 SMAD3 ACTA2
32 11.59 TGFBR2 TGFBR1 SMAD3
33
Show member pathways
11.58 TGFBR2 TGFBR1 TGFB2 SMAD3
34 11.53 TGFBR2 TGFBR1 SMAD3
35 11.5 TGFBR2 TGFBR1 TGFB2
36 11.32 MYLK MYH11 ACTA2
37 11.15 TGFBR2 TGFBR1 TGFB2 SMAD3
38
Show member pathways
11.09 TGFB2 MFAP5 LOX FBN2 FBN1 FBLN5
39 11.05 TGFBR2 TGFBR1 SMAD3
40 10.94 TGFB2 MYLK FBN2 FBN1 ELN EFEMP2
41 10.93 TGFBR2 TGFBR1 TGFB2
42 10.75 TGFBR2 TGFBR1 SMAD3 FBN2 FBN1

GO Terms for Aortic Aneurysm

Cellular components related to Aortic Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.02 TGFB2 NOTCH1 MFAP5 LOX FBN2 FBN1
2 receptor complex GO:0043235 9.67 TGFBR2 TGFBR1 SMAD3 NOTCH1
3 collagen-containing extracellular matrix GO:0062023 9.56 TGFB2 MFAP5 FBN2 FBN1 FBLN5 ELN
4 microfibril GO:0001527 9.46 MFAP5 FBN2 FBN1 EFEMP2
5 elastic fiber GO:0071953 9.43 FBLN5 ELN EFEMP2
6 extracellular matrix GO:0031012 9.23 MFAP5 LOX FBN2 FBN1 FBLN5 ELN

Biological processes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 50)
# Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 10.1 TGFBR2 TGFBR1 TGFB2 PRKG1 MYLK
2 positive regulation of gene expression GO:0010628 10.06 TGFBR1 SMAD3 SLC2A10 NOTCH1 CDKN2B-AS1 ACTA2
3 negative regulation of gene expression GO:0010629 10 TGFB2 SLC2A10 NOTCH1 CDKN2B-AS1
4 in utero embryonic development GO:0001701 9.97 TGFBR2 TGFBR1 SMAD3 NOTCH1
5 positive regulation of cell migration GO:0030335 9.97 TGFBR1 SMAD3 NOTCH1 MYLK CDKN2B-AS1
6 cell cycle arrest GO:0007050 9.9 TGFBR1 TGFB2 SMAD3 NOTCH1
7 skeletal system development GO:0001501 9.89 TGFBR1 TGFB2 SMAD3 FBN1 COL3A1
8 muscle contraction GO:0006936 9.87 MYLK MYH11 ACTA2
9 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.87 TGFBR2 TGFBR1 SMAD3 SLC2A10
10 extracellular matrix organization GO:0030198 9.87 MFAP5 LOX FBN2 FBN1 FBLN5 ELN
11 lung development GO:0030324 9.86 TGFBR2 NOTCH1 LOX
12 heart looping GO:0001947 9.83 TGFBR2 SMAD3 NOTCH1
13 cellular response to transforming growth factor beta stimulus GO:0071560 9.83 TGFBR1 SMAD3 FBN1
14 transforming growth factor beta receptor signaling pathway GO:0007179 9.83 TGFBR2 TGFBR1 TGFB2 SMAD3 COL3A1
15 embryonic limb morphogenesis GO:0030326 9.82 TGFB2 NOTCH1 FBN2
16 outflow tract morphogenesis GO:0003151 9.81 TGFBR2 NOTCH1 ELN
17 epithelial to mesenchymal transition GO:0001837 9.8 TGFBR1 TGFB2 NOTCH1
18 heart development GO:0007507 9.8 TGFBR2 TGFBR1 TGFB2 NOTCH1 LOX FBN1
19 collagen fibril organization GO:0030199 9.78 TGFBR1 TGFB2 LOX COL3A1
20 embryonic cranial skeleton morphogenesis GO:0048701 9.77 TGFBR2 TGFBR1 SMAD3
21 activin receptor signaling pathway GO:0032924 9.73 TGFBR2 TGFBR1 SMAD3
22 pathway-restricted SMAD protein phosphorylation GO:0060389 9.72 TGFBR2 TGFBR1 TGFB2
23 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.71 TGFBR2 TGFBR1
24 endocardial cushion morphogenesis GO:0003203 9.71 TGFB2 NOTCH1
25 cardiac epithelial to mesenchymal transition GO:0060317 9.71 TGFBR1 TGFB2 NOTCH1
26 ventricular septum morphogenesis GO:0060412 9.71 TGFBR2 TGFBR1 TGFB2 NOTCH1
27 regulation of epithelial cell proliferation GO:0050678 9.7 SMAD3 NOTCH1
28 ventricular trabecula myocardium morphogenesis GO:0003222 9.7 TGFBR1 TGFB2 NOTCH1
29 smooth muscle contraction GO:0006939 9.69 MYLK MYH11
30 pulmonary valve morphogenesis GO:0003184 9.69 TGFB2 NOTCH1
31 secondary palate development GO:0062009 9.69 TGFBR2 TGFB2
32 atrioventricular valve morphogenesis GO:0003181 9.69 TGFBR2 TGFB2 NOTCH1
33 supramolecular fiber organization GO:0097435 9.68 MFAP5 COL3A1
34 response to cholesterol GO:0070723 9.68 TGFBR2 TGFBR1
35 cardiac muscle cell proliferation GO:0060038 9.68 TGFB2 NOTCH1
36 cardiac left ventricle morphogenesis GO:0003214 9.67 TGFBR2 NOTCH1
37 somatic stem cell division GO:0048103 9.67 TGFB2 NOTCH1
38 coronary artery morphogenesis GO:0060982 9.66 TGFBR1 NOTCH1
39 membranous septum morphogenesis GO:0003149 9.65 TGFBR2 TGFB2
40 regulation of striated muscle tissue development GO:0016202 9.65 SMAD3 LOX
41 aorta smooth muscle tissue morphogenesis GO:0060414 9.63 MYLK EFEMP2
42 embryonic eye morphogenesis GO:0048048 9.63 MFAP5 FBN2 FBN1
43 glomerular mesangial cell development GO:0072144 9.62 NOTCH1 ACTA2
44 sequestering of TGFbeta in extracellular matrix GO:0035583 9.62 FBN2 FBN1
45 regulation of transforming growth factor beta2 production GO:0032909 9.61 TGFB2 SMAD3
46 endocardial cushion fusion GO:0003274 9.61 TGFBR2 TGFB2
47 positive regulation of epithelial to mesenchymal transition GO:0010718 9.55 TGFBR2 TGFBR1 TGFB2 SMAD3 NOTCH1
48 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.54 TGFBR2 TGFBR1 TGFB2
49 wound healing GO:0042060 9.43 TGFBR2 TGFBR1 TGFB2 SMAD3 LOX COL3A1
50 elastic fiber assembly GO:0048251 8.92 MYH11 LOX FBLN5 EFEMP2

Molecular functions related to Aortic Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta receptor binding GO:0005160 9.48 TGFB2 SMAD3
2 activin binding GO:0048185 9.46 TGFBR2 TGFBR1
3 I-SMAD binding GO:0070411 9.43 TGFBR1 SMAD3
4 SMAD binding GO:0046332 9.43 TGFBR2 TGFBR1 SMAD3
5 extracellular matrix structural constituent GO:0005201 9.43 MFAP5 FBN2 FBN1 ELN EFEMP2 COL3A1
6 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.4 TGFBR2 TGFBR1
7 transforming growth factor beta-activated receptor activity GO:0005024 9.37 TGFBR2 TGFBR1
8 type II transforming growth factor beta receptor binding GO:0005114 9.32 TGFBR1 TGFB2
9 type III transforming growth factor beta receptor binding GO:0034714 9.16 TGFBR2 TGFB2
10 extracellular matrix constituent conferring elasticity GO:0030023 8.92 FBN2 FBN1 FBLN5 ELN

Sources for Aortic Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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