MCID: ART016
MIFTS: 68

Aortic Aneurysm

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Aortic Aneurysm

MalaCards integrated aliases for Aortic Aneurysm:

Name: Aortic Aneurysm 12 74 29 6 42 3 43 15 17 71
Thoracoabdominal Aortic Aneurysm, Ruptured 12 71 32
Aortic Rupture 43 17 71
Abdominal Aortic Aneurysm, Ruptured 12 32
Ruptured Abdominal Aortic Aneurysm 12 71
Thoracic Aortic Aneurysm, Ruptured 12 32
Ruptured Thoracic Aortic Aneurysm 12 71
Aortic Aneurysm Without Mention of Rupture Nos 71
Thoracic Aortic Aneurysm Which Has Ruptured 12
Ruptured Thoracoabdominal Aortic Aneurysm 12
Ruptured Thoracic Aneurysm 12
Aortic Aneurysm, Ruptured 71
Ruptured Aortic Aneurysm 12
Aortic Aneurysms 15

Classifications:



External Ids:

Disease Ontology 12 DOID:3627
UMLS 71 C0003486 C0003496 C0265010 more

Summaries for Aortic Aneurysm

MedlinePlus : 42 An aneurysm is a bulge or "ballooning" in the wall of an artery. Arteries are blood vessels that carry oxygen-rich blood from the heart to other parts of the body. If an aneurysm grows large, it can burst and cause dangerous bleeding or even death. Most aneurysms are in the aorta, the main artery that runs from the heart through the chest and abdomen. There are two types of aortic aneurysm: Thoracic aortic aneurysms (TAA) - these occur in the part of the aorta running through the chest Abdominal aortic aneurysms (AAA) - these occur in the part of the aorta running through the abdomen Most aneurysms are found during tests done for other reasons. Some people are at high risk for aneurysms. It is important for them to get screening, because aneurysms can develop and become large before causing any symptoms. Screening is recommended for people between the ages of 65 and 75 if they have a family history, or if they are men who have smoked. Doctors use imaging tests to find aneurysms. Medicines and surgery are the two main treatments. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Aortic Aneurysm, also known as thoracoabdominal aortic aneurysm, ruptured, is related to aortic aneurysm, familial abdominal, 1 and aortic aneurysm, familial thoracic 6, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Aortic Aneurysm is FBN1 (Fibrillin 1), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Eplerenone and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and spinal cord, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size.

CDC : 3 An aortic aneurysm is a balloon-like bulge in the aorta, the large artery that carries blood from the heart through the chest and torso. Aortic aneurysms work in two ways: • The force of blood pumping can split the layers of the artery wall, allowing blood to leak in between them. This process is called a dissection. • The aneurysm can burst completely, causing bleeding inside the body. This is called a rupture. • Dissections and ruptures are the cause of most deaths from aortic aneurysms.

Wikipedia : 74 An aortic aneurysm is an enlargement (dilatation) of the aorta to greater than 1.5 times normal size.... more...

Related Diseases for Aortic Aneurysm

Diseases related to Aortic Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 895)
# Related Disease Score Top Affiliating Genes
1 aortic aneurysm, familial abdominal, 1 35.1 FBN1 ELN CDKN2B-AS1
2 aortic aneurysm, familial thoracic 6 34.9 TGFBR1 SLC2A10 MYLK MYH11 ACTA2
3 familial abdominal aortic aneurysm 34.6 MYLK FBN1 ELN COL3A1
4 aortic aneurysm, familial thoracic 2 34.6 SLC2A10 FBN1 COL3A1 ACTA2
5 loeys-dietz syndrome 1 33.6 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
6 familial thoracic aortic aneurysm and dissection 33.4 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
7 autosomal recessive cutis laxa type i 33.3 SLC2A10 FBN1 ELN EFEMP2
8 cutis laxa, autosomal dominant 1 33.1 TGFBR2 TGFBR1 SLC2A10 FBN1 ELN EFEMP2
9 loeys-dietz syndrome 5 33.0 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 FBN1
10 aortic aneurysm, familial thoracic 1 32.9 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
11 loeys-dietz syndrome 32.9 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
12 loeys-dietz syndrome 4 32.8 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
13 marfan syndrome 32.7 TGFBR2 TGFBR1 TGFB2 NOTCH1 MYLK MYH11
14 patent ductus arteriosus 1 32.7 TGFBR2 TGFBR1 SLC2A10 NOTCH1 MYLK MYH11
15 loeys-dietz syndrome 3 32.4 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
16 aneurysm 31.9 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
17 aortic valve insufficiency 31.7 TGFBR2 TGFBR1 MYH11 FBN1 ELN ACTA2
18 inguinal hernia 31.4 LOX FBN1 ELN
19 ehlers-danlos syndrome 31.3 TGFBR1 SLC2A10 MYH11 FBN1 ELN COL3A1
20 aortic valve disease 2 31.1 NOTCH1 FBN1 ELN
21 connective tissue disease 31.0 TGFBR2 SMAD3 LOX FBN1 ELN COL3A1
22 ehlers-danlos syndrome, vascular type 31.0 ELN COL3A1
23 cutis laxa 30.9 LOX FBN1 ELN EFEMP2
24 telangiectasis 30.9 TGFBR1 FBN1 ELN
25 scoliosis 30.8 TGFBR2 TGFB2 LOX FBN1 ELN
26 heart valve disease 30.8 NOTCH1 FBN1 ELN
27 supravalvular aortic stenosis 30.8 FBN1 ELN EFEMP2
28 varicose veins 30.7 FBN1 ELN COL3A1
29 mitral valve disease 30.6 TGFB3 TGFB2 FBN1 ELN
30 moyamoya disease 1 30.6 TGFBR2 MYLK MYH11 ELN ACTA2
31 exfoliation syndrome 30.6 LOX FBN1 ELN
32 aortic valve disease 1 30.5 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
33 collagen disease 30.5 TGFBR1 SMAD3 FBN1 ELN COL3A1
34 intracranial aneurysm 30.5 TGFBR2 TGFBR1 TGFB2 LOX ELN COL3A1
35 pseudoxanthoma elasticum 30.4 MYH11 FBN1 ELN
36 hereditary hemorrhagic telangiectasia 30.4 TGFBR2 TGFBR1 TGFB2
37 aortic disease 30.4 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 PRKG1
38 atrial heart septal defect 30.4 NOTCH1 FBN1 ELN
39 brittle bone disorder 30.3 FBN1 ELN COL3A1 BGN
40 arterial tortuosity syndrome 30.2 TGFBR2 TGFBR1 TGFB2 SMAD3 SLC2A10 MYH11
41 heritable thoracic aortic disease 30.2 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 PRKG1
42 bladder diverticulum 30.2 SLC2A10 LOX ELN EFEMP2
43 intraocular pressure quantitative trait locus 30.1 TGFB2 FBN1 ELN CDKN2B-AS1
44 pulmonary fibrosis, idiopathic 30.1 TGFBR1 SMAD3 LOX ELN COL3A1 ACTA2
45 tricuspid valve prolapse 30.1 TGFBR2 TGFBR1 SLC2A10 FBN1 EFEMP2 COL3A1
46 orthostatic intolerance 30.0 TGFBR2 TGFBR1 TGFB2 SMAD3 SLC2A10 FBN1
47 cerebral arterial disease 29.9 ELN COL3A1 CDKN2B-AS1 ACTA2
48 glaucoma, primary open angle 29.9 TGFB2 FBN1 ELN CDKN2B-AS1
49 hypertension, essential 29.8 SMAD3 PRKG1 MYLK LOX FBN1 ELN
50 aortic aneurysm, familial thoracic 4 12.9

Comorbidity relations with Aortic Aneurysm via Phenotypic Disease Network (PDN): (show all 13)


Acute Cystitis Acute Kidney Failure
Acute Vascular Insufficiency of Intestine Aortic Valve Disease 1
Cardiac Arrest Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Paralytic Ileus Peripheral Vascular Disease
Respiratory Failure

Graphical network of the top 20 diseases related to Aortic Aneurysm:



Diseases related to Aortic Aneurysm

Symptoms & Phenotypes for Aortic Aneurysm

UMLS symptoms related to Aortic Aneurysm:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00107-A-1 9.92 TGFBR2
2 Decreased viability GR00221-A-1 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
3 Decreased viability GR00221-A-2 9.92 COL3A1 PRKG1
4 Decreased viability GR00221-A-3 9.92 TGFBR2
5 Decreased viability GR00221-A-4 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
6 Decreased viability GR00301-A 9.92 PRKG1
7 Decreased viability GR00402-S-2 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2

MGI Mouse Phenotypes related to Aortic Aneurysm:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.43 ACTA2 COL3A1 EFEMP2 FBN1 LOX MFAP5
2 cellular MP:0005384 10.29 BGN COL3A1 EFEMP2 FBN1 MYH11 NOTCH1
3 homeostasis/metabolism MP:0005376 10.25 BGN COL3A1 FBN1 LOX MYH11 MYLK
4 immune system MP:0005387 10.22 BGN COL3A1 FBN1 MFAP5 MYLK NOTCH1
5 hematopoietic system MP:0005397 10.2 COL3A1 FBN1 MFAP5 NOTCH1 PRKG1 SLC2A10
6 digestive/alimentary MP:0005381 10.18 COL3A1 MYH11 MYLK NOTCH1 PRKG1 SMAD3
7 mortality/aging MP:0010768 10.17 BGN COL3A1 EFEMP2 FBN1 LOX MYH11
8 integument MP:0010771 10.07 BGN COL3A1 EFEMP2 FBN1 LOX MYH11
9 muscle MP:0005369 10.07 ACTA2 BGN COL3A1 EFEMP2 FBN1 LOX
10 craniofacial MP:0005382 10.04 BGN FBN1 NOTCH1 SMAD3 TGFB2 TGFB3
11 renal/urinary system MP:0005367 9.81 FBN1 MYH11 MYLK NOTCH1 PRKG1 SLC2A10
12 respiratory system MP:0005388 9.7 COL3A1 EFEMP2 FBN1 LOX MYH11 NOTCH1
13 skeleton MP:0005390 9.4 BGN EFEMP2 FBN1 LOX MFAP5 MYLK

Drugs & Therapeutics for Aortic Aneurysm

Drugs for Aortic Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 251)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Eplerenone Approved Phase 4 107724-20-9 150310 443872
2
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198
3
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
4
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
5
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
6
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
7
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
8 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
9
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
10
Nicotine Approved Phase 4 54-11-5 942 89594
11
Tranexamic Acid Approved Phase 4 1197-18-8 5526
12
Iodine Approved, Investigational Phase 4 7553-56-2 807
13
Remifentanil Approved Phase 4 132875-61-7 60815
14
Morphine Approved, Investigational Phase 4 57-27-2 5288826
15
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
16
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
17
Atenolol Approved Phase 4 29122-68-7 2249
18
Atorvastatin Approved Phase 4 134523-00-5 60823
19
Iron Approved, Experimental Phase 4 7439-89-6, 15438-31-0 23925 27284
20
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
21
Desflurane Approved Phase 4 57041-67-5 42113
22
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
23
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
24
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
25
Clevidipine Approved, Investigational Phase 4 167221-71-8
26
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
27
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
28 Pharmaceutical Solutions Phase 4
29 Mineralocorticoids Phase 4
30 Mineralocorticoid Receptor Antagonists Phase 4
31 Diuretics, Potassium Sparing Phase 4
32 Hydroxyethyl Starch Derivatives Phase 4
33 Giapreza Phase 4
34 Angiotensin Receptor Antagonists Phase 4
35 Angiotensin II Type 1 Receptor Blockers Phase 4
36 Angiotensinogen Phase 4
37 Methylprednisolone Acetate Phase 4
38 Antifibrinolytic Agents Phase 4
39 cadexomer iodine Phase 4
40 Narcotics Phase 4
41 Analgesics, Opioid Phase 4
42 Adrenergic Antagonists Phase 4
43 Adrenergic beta-Antagonists Phase 4
44 Adrenergic beta-1 Receptor Antagonists Phase 4
45 Sympatholytics Phase 4
46 Anticholesteremic Agents Phase 4
47 Hypolipidemic Agents Phase 4
48 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
49 Lipid Regulating Agents Phase 4
50 Antigen-Antibody Complex Phase 4

Interventional clinical trials:

(show top 50) (show all 644)
# Name Status NCT ID Phase Drugs
1 Eplerenone in the Management of Abdominal Aortic Aneurysms: A Proof-Of-Concept Randomised Controlled Trial Unknown status NCT02345590 Phase 4 Eplerenone
2 Prophylactic Mesh Implantation After Abdominal Aortic Aneurysm Repair. A Prospective, Randomised, Controlled Study Unknown status NCT01353443 Phase 4
3 A Randomised Controlled Trial of the Effectiveness of Acetazolamide in Reducing Cerebrospinal Fluid Pressure for Patients Undergoing Thoracic-abdominal Aortic Repair Unknown status NCT01889498 Phase 4 Acetazolamide
4 The Effect of Immunonutrition on Outcome and Postoperative Recovery in Patients Undergoing Elective Surgical Repair of a Thoraco (Abdominal) Aneurysm Aorta Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
5 Study Using Plasma for Patients Requiring Emergency Surgery: A Randomized Pilot Trial of Early Plasma for Patients Undergoing Emergency Surgery for Hemorrhagic Shock Unknown status NCT01221389 Phase 4 Human Plasma
6 Endovascular Treatment of Thoracic Aortic Aneurysms Using the TALENT Stent Graft System Completed NCT00802984 Phase 4
7 A Clinical Evaluation of the GORE EXCLUDER® Bifurcated Endoprosthesis - Low Permeability in the Primary Treatment of Infrarenal Abdominal Aortic Aneurysms Completed NCT00593814 Phase 4
8 Study of the Effectiveness of Telmisartan in Slowing the Progression of Abdominal Aortic Aneurysms Completed NCT01683084 Phase 4 Telmisartan;Placebo
9 TALENT Endoluminal Stent Graft System for the Treatment of Abdominal Aortic Aneurysms Completed NCT00803075 Phase 4
10 Prevalence of Abdominal Aortic Aneurysm in Patients Undergoing Coronary Angiography Completed NCT01239225 Phase 4
11 CUstodiol Versus RInger: whaT Is the Best Agent? A Randomized Double Blind Trial. Completed NCT02327611 Phase 4 Custodiol;Enriched Ringer's lactate solution
12 Opioid-potentiated Volative Anaesthetic(Sevoflurane)Compared to Remifentanil and Propofol During Abdominal Aortic Aneurysm Surgery Completed NCT00538421 Phase 4 Propofol;Sevoflurane
13 CSP #498 - Open Versus Endovascular Repair (OVER) Trial for Abdominal Aortic Aneurysms Completed NCT00094575 Phase 4
14 Coagulopathy During Surgery for the Repair of Extent 4 Thoraco-Abdominal Aortic Aneurysms - Feasibility Study of the Use of Fibrinogen Concentrate by Infusion in Place of Fresh Frozen Plasma. Completed NCT00994045 Phase 4
15 Transversus Abdominis Plane (TAP) Block in Open Abdominal Aortic Surgery : Randomized Controlled Doubled-blind Trial Comparing Ropivacaine 0.2% Versus Placebo Completed NCT03657979 Phase 4 Ropivacaine;Placebo
16 Comparison of Intravenous Anesthetics and Volatile Anesthetics on Postoperative Cognitive Dysfunction of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities. Completed NCT02107170 Phase 4 Sevoflurane;Propofol;Remifentanil
17 Comparison of High Iodine Concentration Contrast Material (Isovue 370) vs Standard Protocol (Isovue 300) in Thoracoabdominal Aortic Computed Tomographic Angiography (CTA) for Radiation Dose Reduction Completed NCT02291718 Phase 4 Isovue
18 Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial) Completed NCT01904981 Phase 4 Beta-blocker-Atenolol 50mg, PO(peroral), Once daily;Angiotensin receptor blocker-Valsartan 80mg, PO(peroral), Once daily
19 Tranexamic Acid in Major Vascular Surgery. A Randomized Placebo-controlled Trial. Completed NCT02335359 Phase 4 tranexamic acid diluted in 100 ml of saline solution (loading dose);tranexamic acid undiluted (continous infusion);Placebo
20 Randomised Controlled Trial of Effect of Pre-operative Statin Use on Matrix Metalloproteinases (MMP) & Tissue Inhibitors of Matrix Metalloproteinases (TIMP) in Abdominal Aortic Aneurysm (AAA). Completed NCT01062802 Phase 4 Atorvastatin
21 A Controlled Trial of Effectiveness of a Backward Walking Program in Patients Recovering From an Abdominal Aorta Surgery Completed NCT00819936 Phase 4
22 Atorvastatin 80mg Versus Atorvastatin 20mg in Perioperative Vascular Surgery to Evaluate Cardiovascular Outcomes Completed NCT00610545 Phase 4 Atorvastatin;Atorvastatin
23 Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Randomized Clinical Trial Completed NCT02678728 Phase 4 Dexmedetomidine;normal saline
24 A Trial of Telmisartan Prevention of Cardiovascular Disease Completed NCT01075698 Phase 4 Non-ARB (standard therapy);ARB (Telmisartan)
25 Effects of OctaplasLG® on Endothelial Integrity in Patients Undergoing Emergency Surgery for Thoracic Aortic Dissections - a Randomized, Controlled, Single-blinded Investigator-initiated Pilot Trial Completed NCT02253082 Phase 4 OctaplasLG®
26 Impact of Carotid Plaque Screening on Smoking Cessation and Control of Other Cardiovascular Risk Factors: A Randomized Controlled Trial. Completed NCT00548665 Phase 4
27 Randomized Trial of Pulsatile vs Non Pulsatile Perfusion on Short Term Changes in Kidney Function Using an Intra-Aortic Ballooon Pump During Cardioplegic Arrest in Patients Undergoing Myocardial Reperfusion Completed NCT00454428 Phase 4
28 Physician-Initiated PMCF Trial Investigating the BeGraft Peripheral Stent Graft System for the Treatment of Iliac Lesions Completed NCT02211716 Phase 4
29 Randomized Preventive Vascular Screening Trial of 65-74 Year Old Men in the Central Region of Denmark Recruiting NCT00662480 Phase 4
30 Noninvasive Assessment of Abdominal Aortic Aneurysm (AAA) Wall Structural Integrity and Inflammation as Predictors of Expansion and/or Rupture Recruiting NCT03231397 Phase 4 Assess AAA rupture risk by PET-CTA scans;18F-fludeoxyglucose (FDG)
31 Fast-track in Endovascular Aortic Aneurysm Repair With Desflurane and Sevoflurane: a Randomized Clinical Trial Recruiting NCT03917186 Phase 4 Sevoflurane;Desflurane
32 A Phase IV Double-blind, Randomised, Parallel Group Comparison of the Efficacy and Safety of Preoperative Intravenous Ferric Carboxymaltose and Placebo in the Treatment of Patients Undergoing Elective or Urgent Cardiac Surgery Recruiting NCT03574311 Phase 4 Ferric carboxymaltose
33 Pilot Study of of Renal Arterial Sympathetic Denervation by Cryotherapy During Open Surgery for Aortic Aneurysm Active, not recruiting NCT02345603 Phase 4
34 ACTION-1: ACT Guided Heparinization During Open Abdominal Aortic Aneurysm Repair, a Randomised Trial. Not yet recruiting NCT04061798 Phase 4 ACT guided heparinization
35 Intercostal Nerve Cryoablation for Postoperative Pain Management Not yet recruiting NCT03972397 Phase 4 Bupivacaine liposomal injectable suspension;Patient-controlled analgesia (PCA)
36 Randomized Clinical Trial Comparing Surveillance and Selective Surgical Treatment for Abdominal Aortic Aneurysms Less Than 5.5 cm in Diameter Versus Early Endovascular Treatment Terminated NCT00118573 Phase 4
37 Phase 4 Study of Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic Aneurysms Terminated NCT00409344 Phase 4 Dexmedetomidine
38 Long-term Benefit of Aortic Stent-graft in Patients With Distal Aortic Dissection Terminated NCT01354119 Phase 4
39 A Safety and Efficacy Study of Blood Pressure Control in Acute Aortic Emergencies - A Pilot Study (PROMPT) Terminated NCT01033370 Phase 4 clevidipine.
40 Comparison of a Single Dose Fibrinogen With Placebo and the Number of Blood Transfusions After Ascending Aorta Surgery (FIBTEG Study) Terminated NCT02299947 Phase 4 Haemocomplettan P;Placebo
41 Extensive Type A Dissections and Thoracic/ Thoraco-Abdominal Withdrawn NCT01107366 Phase 4
42 Expertise Based Randomized Controlled Trial of Open Versus Endovascular Repair of Abdominal Aortic Aneurysms: A Pilot Study Unknown status NCT00358085 Phase 3
43 Prospective, Multicenter, Single Arm Phase II Study of the Powerlink 34mm Cuff for the Endovascular Repair of Abdominal Aortic Aneurysms Unknown status NCT00706394 Phase 2, Phase 3
44 Magnetic Resonance Imaging of Aortic Aneurysm Instability Unknown status NCT00794092 Phase 2, Phase 3 Sinerem administration
45 Prophylactic Use of Nesiritide (Brain Natriuretic Peptide, BNP) for the Prevention of Acute Renal Failure in Thoracic Aortic Aneurysm Surgery Patients Unknown status NCT00110201 Phase 3 Nesiritide
46 Efficacy of the Ultrasound-guidedTransversus Abdominis Plane (TAP) Block on Postoperative Pain Control in Open Aortic Abdominal Aneurysm Repair Surgery Unknown status NCT02292667 Phase 3 PCA with Chlorhydrate of Morphine;Acetaminophen
47 Effects of Losartan vs. Nebivolol vs. the Association of Both on the Progression of Aortic Root Dilation in Marfan Syndrome (MFS) With FBN1 Gene Mutations. Unknown status NCT00683124 Phase 3 Losartan and nebivolol;Losartan;Nebivolol
48 A Prospective, Multicenter Study of the Cordis Endovascular QUANTUM LP™ Stent Graft System for the Treatment of Abdominal Aortic Aneurysms (AAA)-FORTRON Completed NCT00233688 Phase 3
49 Evaluation of the Medtronic Vascular Talent Thoracic Stent Graft System for the Treatment of Thoracic Aortic Aneurysms Completed NCT00604799 Phase 2, Phase 3
50 A Study to Assess the Acute Technical Success of Aorfix™ Stent Grafts in the Treatment of Abdominal Aortic and Aorto-Iliac Aneurysm Where a Significant Degree of Vessel Angulation Exists at the Neck of the Aneurysm Completed NCT00442065 Phase 2, Phase 3

Search NIH Clinical Center for Aortic Aneurysm

Inferred drug relations via UMLS 71 / NDF-RT 50 :


trimethaphan camsylate

Cochrane evidence based reviews: aortic aneurysm

Genetic Tests for Aortic Aneurysm

Genetic tests related to Aortic Aneurysm:

# Genetic test Affiliating Genes
1 Aortic Aneurysm 29

Anatomical Context for Aortic Aneurysm

MalaCards organs/tissues related to Aortic Aneurysm:

40
Kidney, Heart, Spinal Cord, Smooth Muscle, Lung, Testes, Colon

Publications for Aortic Aneurysm

Articles related to Aortic Aneurysm:

(show top 50) (show all 23057)
# Title Authors PMID Year
1
The Effect of Remote Ischaemic Preconditioning on Arterial Stiffness in Patients Undergoing Vascular Surgery: A Randomised Clinical Trial. 61 42
31126835 2019
2
Open versus Endovascular Repair of Abdominal Aortic Aneurysm. 61 42
31141634 2019
3
Usefulness of ultrasound in the management of aortic dissection. 42
31054559 2018
4
First Two Cases of Infected Aortic Aneurysm Caused by Non-Vaccine Streptococcus pneumoniae Serotype 23A. 61
31858770 2020
5
A review of thoracic aortic aneurysm disease. 61
32015897 2020
6
Network-based analysis reveals novel gene signatures in the peripheral blood of patients with sporadic nonsyndromic thoracic aortic aneurysm. 61
31489966 2020
7
Internal iliac artery aneurysm embolization with direct percutaneous puncture and thrombin injection. 61
31890070 2020
8
Assessment of Spinal Cord Ischemia With Near-Infrared Spectroscopy: Myth or Reality? 61
31399303 2020
9
Initial experience with polymer endovascular aneurysm repair using the Alto stent graft. 61
32025596 2020
10
Fenestrated endovascular aneurysm repair with concomitant horseshoe kidney. 61
32025598 2020
11
Wrapping of ascending aortic aneurysm with supra-aortic debranching and endovascular repair for aortic arch aneurysm and ruptured descending thoracic aortic aneurysm. 61
31856350 2020
12
Novel SMAD3 p.Arg386Thr genetic variant co-segregating with thoracic aortic aneurysm and dissection. 61
32022471 2020
13
Type B Aortic Dissection in Young Individuals With Confirmed and Presumed Heritable Thoracic Aortic Disease. 61
31376376 2020
14
Thoracoabdominal Aortic Aneurysm in a Patient With Takayasu Arteritis. 61
31254506 2020
15
Minimally Invasive Open Conversion for Late EVAR Failure. 61
31626941 2020
16
Co-localization of microstructural damage and excessive mechanical strain at aortic branches in angiotensin-II-infused mice. 61
31273562 2020
17
Incidence of Post-Implantation Syndrome with Different Endovascular Aortic Aneurysm Repair Modalities and Devices and Related Etiopathogenetic Implications. 61
31629127 2020
18
Total Endovascular Aortic arch Replacement with Chimney/Sandwich Techniques. 61
31622748 2020
19
The genetics of aortopathies: Hereditary thoracic aortic aneurysms and dissections. 61
32034893 2020
20
Randomized clinical trial of an elastomeric sealant for hemostasis in thoracic aortic surgery. 61
31300951 2020
21
Chronic mTOR activation induces a degradative smooth muscle cell phenotype. 61
32039915 2020
22
Remote Ischaemic Preconditioning Attenuates Cardiac Biomarkers During Vascular Surgery: A Randomised Clinical Trial. 61
31870692 2020
23
Recurrent Aortic Infections Due to Unrecognized Aorto-Enteric Fistula. 61
31622759 2020
24
Elevated neutrophil-lymphocyte ratio predicts mortality following elective endovascular aneurysm repair. 61
32037083 2020
25
Transfusion Timing and Postoperative Myocardial Infarction and Death in Patients Undergoing Common Vascular Procedures. 61
31626929 2020
26
Day of surgery: the impact on patient length of stay in a tertiary vascular unit. 61
31155908 2020
27
Emergent Endovascular Treatment in Primary Ilio-enteric Fistula. 61
31622766 2020
28
Endovascular Aneurysm Sealing is Associated with Higher Medium-Term Survival than Traditional EVAR. 61
31629124 2020
29
Impact of Endovascular Repair on the Outcomes of Octogenarians with Ruptured Abdominal Aortic Aneurysms: A Nationwide Japanese Study. 61
31843242 2020
30
Surgical Repair of Juxtarenal Abdominal Aortic Aneurysms and safety of Suprarenal Aortic Clamping. 61
32016545 2020
31
Postoperatively increased bioactive adrenomedullin is related to adverse outcome after complex aortic surgery. 61
32011218 2020
32
Clostridium septicum aortitis: A kiss of the devil. 61
31872897 2020
33
The TGF-β pathway plays a key role in aortic aneurysms. 61
31707165 2020
34
Treatment of High Surgical Risk Thoracoabdominal Aortic Aneurysms with Stent Graft and Multilayer Bare Stents Joint Technique: Mid-Long-Term Clinical Results. 61
31536795 2020
35
Fenestrated Endovascular Repair for Pararenal or Juxtarenal Abdominal Aortic Aneurysms: a Systematic Review. 61
31629840 2020
36
Abdominal Aortic Aneurysm Screening. 61
31997324 2020
37
The Infected Abdominal Aortic Aneurysm. 61
32018023 2020
38
Reply to "Controversies in screening for abdominal aortic aneurysm". 61
31928652 2020
39
CT-Ultrasound Fusion for Abdominal Aortic Aneurysm Measurement. 61
31825260 2020
40
[Colonic ischemia after open and endovascular aortic surgery : Epidemiology, Risk Factors, Diagnosis And Therapy]. 61
32002560 2020
41
Congenital Lymphatic Malformation and Aortic Aneurysm in a Patient with TSC2 Mutation. 61
31505689 2020
42
Pharmacological Inhibition of Cathepsin S Suppresses Abdominal Aortic Aneurysm in Mice. 61
32033870 2020
43
Endovascular Aortic Repair Is a Viable Strategy for Treatment of Primary Infected Abdominal Aortic Aneurysm. 61
30802582 2020
44
Horseshoe Kidney Protection with Histidine-Tryptophan-Ketoglutarate Solution during Surgical Abdominal Aortic Aneurysm Repair. 61
31622767 2020
45
Morphologic and Operative Evolution of Open Ruptured Abdominal Aortic Aneurysm Repair. 61
31629122 2020
46
Readability and Understandability Analysis of Online Materials Related to Abdominal Aortic Aneurysm Repair. 61
31607232 2020
47
HIV associated aortitis causing rapid development of an abdominal aortic aneurysm. 61
32018021 2020
48
A Cohort Longitudinal Study Identifies Morphology and Hemodynamics Predictors of Abdominal Aortic Aneurysm Growth. 61
31637578 2020
49
TROVE2 strengthens the anti-inflammatory effect via macrophage polarization by estrogen induction in abdominal aortic aneurysm. 61
31863777 2020
50
Circular RNA expression profile and its potential regulative role in human abdominal aortic aneurysm. 61
32039711 2020

Variations for Aortic Aneurysm

ClinVar genetic disease variations for Aortic Aneurysm:

6 ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 FBN1 NM_000138.4(FBN1):c.7754T>C (p.Ile2585Thr)SNV Pathogenic/Likely pathogenic 163462 rs727503054 15:48712949-48712949 15:48420752-48420752
2 TGFB2 NM_001135599.3(TGFB2):c.440C>T (p.Pro147Leu)SNV Conflicting interpretations of pathogenicity 213840 rs149533093 1:218578520-218578520 1:218405178-218405178
3 COL3A1 NM_000090.3(COL3A1):c.505C>T (p.Leu169Phe)SNV Conflicting interpretations of pathogenicity 161216 rs111391222 2:189851842-189851842 2:188987116-188987116
4 MYH11 NM_002474.3(MYH11):c.4942C>T (p.Arg1648Cys)SNV Uncertain significance 161318 rs369409348 16:15814019-15814019 16:15720162-15720162

Expression for Aortic Aneurysm

Search GEO for disease gene expression data for Aortic Aneurysm.

Pathways for Aortic Aneurysm

Pathways related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
2
Show member pathways
13.28 TGFBR2 TGFBR1 TGFB3 TGFB2 MYLK MYH11
3
Show member pathways
13.24 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
4
Show member pathways
13.05 TGFBR1 TGFB3 TGFB2 FBN1 ELN EFEMP2
5
Show member pathways
12.94 TGFBR2 TGFBR1 TGFB3 TGFB2 PRKG1 MYH11
6
Show member pathways
12.88 TGFBR2 TGFBR1 TGFB3 TGFB2 MYLK ACTA2
7 12.86 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
8
Show member pathways
12.84 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
9
Show member pathways
12.79 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
10
Show member pathways
12.62 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
11
Show member pathways
12.5 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
12
Show member pathways
12.45 PRKG1 MYLK MYH11 ACTA2
13 12.37 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
14 12.28 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
15
Show member pathways
12.26 TGFB3 TGFB2 MFAP5 LOX FBN1 ELN
16
Show member pathways
12.22 TGFBR2 TGFBR1 TGFB2 SMAD3
17 12.21 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
18 12.19 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
19 12.16 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
20 12.11 TGFBR1 SMAD3 MYLK ACTA2
21
Show member pathways
12.08 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
22
Show member pathways
12.05 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
23 11.89 TGFB3 TGFB2 COL3A1
24 11.89 TGFBR1 TGFB3 TGFB2 NOTCH1
25 11.87 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
26
Show member pathways
11.84 TGFBR2 TGFBR1 SMAD3
27
Show member pathways
11.81 TGFBR2 TGFBR1 SMAD3 LOX
28 11.8 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 COL3A1
29 11.72 TGFBR2 TGFBR1 SMAD3
30 11.71 TGFBR2 TGFBR1 SMAD3
31
Show member pathways
11.71 TGFBR2 TGFBR1 SMAD3
32 11.71 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 FBN1
33 11.64 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 ACTA2
34 11.62 TGFBR2 TGFBR1 SMAD3
35 11.61 TGFB3 TGFB2 BGN
36
Show member pathways
11.6 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
37 11.58 TGFBR2 TGFBR1 TGFB3 SMAD3
38 11.54 TGFBR2 TGFBR1 TGFB2
39 11.48 TGFBR2 TGFBR1 TGFB3 TGFB2
40 11.39 MYLK MYH11 ACTA2
41
Show member pathways
11.26 TGFBR2 TGFBR1 TGFB3
42 11.24 TGFBR2 TGFBR1 TGFB3
43 11.16 TGFBR2 TGFBR1 SMAD3 FBN1
44 11.13 TGFBR2 TGFBR1 SMAD3
45 11.03 TGFB3 TGFB2 MYLK FBN1 ELN EFEMP2
46 11.03 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
47
Show member pathways
11.03 TGFB3 TGFB2 MFAP5 LOX FBN1 ELN

GO Terms for Aortic Aneurysm

Cellular components related to Aortic Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 TGFB3 TGFB2 NOTCH1 MFAP5 LOX FBN1
2 receptor complex GO:0043235 9.56 TGFBR2 TGFBR1 SMAD3 NOTCH1
3 extracellular matrix GO:0031012 9.43 MFAP5 LOX FBN1 ELN COL3A1 BGN
4 microfibril GO:0001527 9.32 MFAP5 FBN1
5 collagen-containing extracellular matrix GO:0062023 9.23 TGFB3 TGFB2 MFAP5 FBN1 ELN EFEMP2

Biological processes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 10.11 TGFBR2 TGFBR1 TGFB3 TGFB2 NOTCH1
2 positive regulation of gene expression GO:0010628 10.09 TGFBR1 SMAD3 NOTCH1 CDKN2B-AS1 ACTA2
3 negative regulation of cell proliferation GO:0008285 10.09 TGFBR2 TGFB3 TGFB2 SMAD3 NOTCH1
4 regulation of gene expression GO:0010468 10.01 TGFBR2 TGFBR1 NOTCH1 LOX
5 positive regulation of cell migration GO:0030335 10 TGFBR1 SMAD3 NOTCH1 MYLK CDKN2B-AS1
6 regulation of cell proliferation GO:0042127 9.98 TGFBR2 TGFB3 TGFB2 NOTCH1
7 in utero embryonic development GO:0001701 9.98 TGFBR2 TGFBR1 TGFB3 SMAD3 NOTCH1
8 response to hypoxia GO:0001666 9.96 TGFBR2 TGFB3 TGFB2 SMAD3
9 cell cycle arrest GO:0007050 9.92 TGFBR1 TGFB2 SMAD3 NOTCH1
10 muscle contraction GO:0006936 9.9 MYLK MYH11 ACTA2
11 lung development GO:0030324 9.89 TGFBR2 NOTCH1 LOX
12 skeletal system development GO:0001501 9.88 TGFBR1 TGFB2 SMAD3 FBN1 COL3A1
13 heart looping GO:0001947 9.86 TGFBR2 SMAD3 NOTCH1
14 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.86 TGFBR2 TGFBR1 TGFB3 SMAD3
15 cellular response to transforming growth factor beta stimulus GO:0071560 9.85 TGFBR1 SMAD3 FBN1
16 SMAD protein signal transduction GO:0060395 9.85 TGFB3 TGFB2 SMAD3
17 outflow tract morphogenesis GO:0003151 9.85 TGFBR2 NOTCH1 ELN
18 extracellular matrix organization GO:0030198 9.85 MFAP5 LOX FBN1 ELN COL3A1 BGN
19 positive regulation of stress fiber assembly GO:0051496 9.84 TGFBR1 TGFB3 SMAD3
20 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.83 TGFBR1 TGFB3 TGFB2
21 epithelial to mesenchymal transition GO:0001837 9.8 TGFBR1 TGFB2 NOTCH1
22 heart development GO:0007507 9.8 TGFBR2 TGFBR1 TGFB2 NOTCH1 LOX FBN1
23 embryonic cranial skeleton morphogenesis GO:0048701 9.79 TGFBR2 TGFBR1 SMAD3
24 digestive tract development GO:0048565 9.79 TGFBR2 TGFB3 COL3A1
25 collagen fibril organization GO:0030199 9.76 TGFBR1 TGFB2 LOX COL3A1
26 cell-cell junction organization GO:0045216 9.75 TGFB3 TGFB2 SMAD3
27 activin receptor signaling pathway GO:0032924 9.74 TGFBR2 TGFBR1 SMAD3
28 regulation of epithelial cell proliferation GO:0050678 9.72 SMAD3 NOTCH1
29 negative regulation of immune response GO:0050777 9.72 TGFB2 COL3A1
30 pulmonary valve morphogenesis GO:0003184 9.72 TGFB2 NOTCH1
31 ventricular trabecula myocardium morphogenesis GO:0003222 9.72 TGFBR1 TGFB2 NOTCH1
32 supramolecular fiber organization GO:0097435 9.71 MFAP5 COL3A1
33 cardiac muscle cell proliferation GO:0060038 9.71 TGFB2 NOTCH1
34 positive regulation of SMAD protein signal transduction GO:0060391 9.71 TGFBR1 TGFB3
35 response to cholesterol GO:0070723 9.71 TGFBR2 TGFBR1
36 secondary palate development GO:0062009 9.71 TGFBR2 TGFB3 TGFB2
37 ventricular septum morphogenesis GO:0060412 9.71 TGFBR2 TGFBR1 TGFB2 NOTCH1
38 somatic stem cell division GO:0048103 9.7 TGFB2 NOTCH1
39 salivary gland morphogenesis GO:0007435 9.7 TGFB3 TGFB2
40 cardiac left ventricle morphogenesis GO:0003214 9.7 TGFBR2 NOTCH1
41 membranous septum morphogenesis GO:0003149 9.7 TGFBR2 TGFB2
42 pathway-restricted SMAD protein phosphorylation GO:0060389 9.7 TGFBR2 TGFBR1 TGFB2
43 coronary artery morphogenesis GO:0060982 9.69 TGFBR1 NOTCH1
44 cardiac epithelial to mesenchymal transition GO:0060317 9.69 TGFBR1 TGFB2 NOTCH1
45 cell growth GO:0016049 9.68 TGFB3 TGFB2
46 atrioventricular valve morphogenesis GO:0003181 9.67 TGFBR2 TGFB2 NOTCH1
47 aorta smooth muscle tissue morphogenesis GO:0060414 9.65 MYLK COL3A1
48 regulation of striated muscle tissue development GO:0016202 9.65 SMAD3 LOX
49 negative regulation of macrophage cytokine production GO:0010936 9.65 TGFB3 TGFB2
50 glomerular mesangial cell development GO:0072144 9.64 NOTCH1 ACTA2

Molecular functions related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta receptor binding GO:0005160 9.54 TGFB3 TGFB2 SMAD3
2 activin binding GO:0048185 9.49 TGFBR2 TGFBR1
3 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.48 TGFBR2 TGFBR1
4 extracellular matrix constituent conferring elasticity GO:0030023 9.46 FBN1 ELN
5 SMAD binding GO:0046332 9.46 TGFBR2 TGFBR1 SMAD3 COL3A1
6 type I transforming growth factor beta receptor binding GO:0034713 9.43 TGFBR2 TGFB3
7 transforming growth factor beta binding GO:0050431 9.43 TGFBR2 TGFBR1 TGFB3
8 transforming growth factor beta-activated receptor activity GO:0005024 9.4 TGFBR2 TGFBR1
9 type III transforming growth factor beta receptor binding GO:0034714 9.32 TGFB3 TGFB2
10 type II transforming growth factor beta receptor binding GO:0005114 9.13 TGFBR1 TGFB3 TGFB2
11 extracellular matrix structural constituent GO:0005201 9.1 MFAP5 FBN1 ELN EFEMP2 COL3A1 BGN

Sources for Aortic Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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