MCID: ART016
MIFTS: 71

Aortic Aneurysm

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Aortic Aneurysm

MalaCards integrated aliases for Aortic Aneurysm:

Name: Aortic Aneurysm 12 75 29 6 43 3 44 15 17 72
Thoracoabdominal Aortic Aneurysm, Ruptured 12 72 33
Aortic Rupture 44 17 72
Abdominal Aortic Aneurysm, Ruptured 12 33
Ruptured Abdominal Aortic Aneurysm 12 72
Thoracic Aortic Aneurysm, Ruptured 12 33
Ruptured Thoracic Aortic Aneurysm 12 72
Aortic Aneurysm Without Mention of Rupture Nos 72
Thoracic Aortic Aneurysm Which Has Ruptured 12
Ruptured Thoracoabdominal Aortic Aneurysm 12
Ruptured Thoracic Aneurysm 12
Aortic Aneurysm, Ruptured 72
Ruptured Aortic Aneurysm 12
Aortic Aneurysms 15

Classifications:



External Ids:

Disease Ontology 12 DOID:3627
UMLS 72 C0003486 C0003496 C0265010 more

Summaries for Aortic Aneurysm

MedlinePlus : 43 An aneurysm is a bulge or "ballooning" in the wall of an artery. Arteries are blood vessels that carry oxygen-rich blood from the heart to other parts of the body. If an aneurysm grows large, it can burst and cause dangerous bleeding or even death. Most aneurysms are in the aorta, the main artery that runs from the heart through the chest and abdomen. There are two types of aortic aneurysm: Thoracic aortic aneurysms (TAA) - these occur in the part of the aorta running through the chest Abdominal aortic aneurysms (AAA) - these occur in the part of the aorta running through the abdomen Most aneurysms are found during tests done for other reasons. Some people are at high risk for aneurysms. It is important for them to get screening, because aneurysms can develop and become large before causing any symptoms. Screening is recommended for people between the ages of 65 and 75 if they have a family history, or if they are men who have smoked. Doctors use imaging tests to find aneurysms. Medicines and surgery are the two main treatments. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Aortic Aneurysm, also known as thoracoabdominal aortic aneurysm, ruptured, is related to aortic aneurysm, familial thoracic 6 and familial thoracic aortic aneurysm and dissection, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Aortic Aneurysm is FBN1 (Fibrillin 1), and among its related pathways/superpathways are ERK Signaling and PAK Pathway. The drugs Angiotensin II and Telmisartan have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and spinal cord, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size.

CDC : 3 An aortic aneurysm is a balloon-like bulge in the aorta, the large artery that carries blood from the heart through the chest and torso. Aortic aneurysms work in two ways: • The force of blood pumping can split the layers of the artery wall, allowing blood to leak in between them. This process is called a dissection. • The aneurysm can burst completely, causing bleeding inside the body. This is called a rupture. • Dissections and ruptures are the cause of most deaths from aortic aneurysms.

Wikipedia : 75 An aortic aneurysm is an enlargement (dilatation) of the aorta to greater than 1.5 times normal size.... more...

Related Diseases for Aortic Aneurysm

Diseases related to Aortic Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 877)
# Related Disease Score Top Affiliating Genes
1 aortic aneurysm, familial thoracic 6 35.1 MYLK MYH11 ACTA2
2 familial thoracic aortic aneurysm and dissection 34.8 TGFBR2 TGFBR1 SMAD3 FBN1 COL3A1
3 aortic aneurysm, familial thoracic 2 34.6 SLC2A10 FBN1 ACTA2
4 aortic aneurysm, familial abdominal, 1 34.5 FBN1 ELN CDKN2B-AS1
5 familial abdominal aortic aneurysm 34.4 MYLK FBN1 ELN COL3A1
6 loeys-dietz syndrome 1 33.5 TGFBR2 TGFBR1 TGFB2 SMAD3 MYH11 FBN1
7 marfan syndrome 32.8 TGFBR2 TGFBR1 FBN1 ELN COL3A1 ACTA2
8 cutis laxa, autosomal recessive, type ib 32.8 LOX ELN EFEMP2
9 loeys-dietz syndrome 32.6 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 MYLK
10 loeys-dietz syndrome 4 32.6 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
11 autosomal recessive cutis laxa type i 32.6 TGFBR2 TGFBR1 LOX ELN EFEMP2
12 aortic aneurysm, familial thoracic 1 32.4 TGFBR2 TGFBR1 SMAD3 SLC2A10 MYH11 HIF1A-AS1
13 aortic valve insufficiency 31.9 NOTCH1 FBN1 ELN
14 aortic valve disease 1 31.4 TGFBR2 NOTCH1 FBN1 ELN ACTA2
15 loeys-dietz syndrome 3 31.2 TGFBR2 TGFBR1 TGFB2 SMAD3 PRKG1 MYLK
16 connective tissue disease 31.0 FBN1 ELN COL3A1 ACTA2
17 ehlers-danlos syndrome, vascular type 30.9 ELN COL3A1
18 mitral valve disease 30.5 TGFB3 TGFB2 FBN1
19 tricuspid valve prolapse 30.5 SMAD3 FBN1
20 exfoliation syndrome 30.5 LOX FBN1 ELN
21 arterial tortuosity syndrome 30.4 TGFBR1 SLC2A10 ELN EFEMP2
22 char syndrome 30.4 TGFBR2 FBN1 COL3A1 ACTA2
23 intracranial aneurysm 29.9 LOX ELN COL3A1 CDKN2B-AS1
24 aortic disease 29.9 TGFBR2 TGFBR1 TGFB2 PRKG1 NOTCH1 MYH11
25 cerebral arterial disease 29.4 ELN CDKN2B-AS1 ACTA2
26 glaucoma, primary open angle 29.2 TGFB2 ELN CDKN2B-AS1
27 open-angle glaucoma 29.0 TGFB2 ELN CDKN2B-AS1
28 aortic aneurysm, familial thoracic 4 12.9
29 aortic aneurysm, familial thoracic 10 12.8
30 aortic aneurysm, familial thoracic 9 12.8
31 aortic aneurysm, familial thoracic 11 12.8
32 aortic aneurysm, familial thoracic 8 12.8
33 aortic aneurysm, familial thoracic 7 12.7
34 aortic aneurysm, familial abdominal, 2 12.6
35 aortic aneurysm, familial abdominal, 4 12.5
36 aortic aneurysm, familial abdominal, 3 12.5
37 rare disease with thoracic aortic aneurysm and aortic dissection 12.5
38 loeys-dietz syndrome 2 12.4
39 aneurysm 12.3
40 cutis laxa, autosomal dominant 1 11.8
41 meester-loeys syndrome 11.8
42 phace association 11.6
43 patent ductus arteriosus 1 11.6
44 temporal arteritis 11.6
45 loeys-dietz syndrome 5 11.6
46 cystic medial necrosis of aorta 11.6
47 multisystemic smooth muscle dysfunction syndrome 11.6
48 cutis laxa, autosomal dominant 2 11.3
49 cutis laxa, autosomal dominant 3 11.3
50 paraplegia 11.1

Comorbidity relations with Aortic Aneurysm via Phenotypic Disease Network (PDN): (show all 13)


Acute Cystitis Acute Kidney Failure
Acute Vascular Insufficiency of Intestine Aortic Valve Disease 1
Cardiac Arrest Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Paralytic Ileus Peripheral Vascular Disease
Respiratory Failure

Graphical network of the top 20 diseases related to Aortic Aneurysm:



Diseases related to Aortic Aneurysm

Symptoms & Phenotypes for Aortic Aneurysm

UMLS symptoms related to Aortic Aneurysm:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00107-A-1 9.92 TGFBR2
2 Decreased viability GR00221-A-1 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
3 Decreased viability GR00221-A-2 9.92 COL3A1 PRKG1
4 Decreased viability GR00221-A-3 9.92 TGFBR2
5 Decreased viability GR00221-A-4 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
6 Decreased viability GR00301-A 9.92 PRKG1
7 Decreased viability GR00402-S-2 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2

MGI Mouse Phenotypes related to Aortic Aneurysm:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.44 ACTA2 COL3A1 EFEMP2 FBN1 LOX MFAP5
2 cellular MP:0005384 10.3 BGN COL3A1 EFEMP2 FBN1 MYH11 NOTCH1
3 homeostasis/metabolism MP:0005376 10.25 BGN COL3A1 FBN1 LOX MYH11 MYLK
4 growth/size/body region MP:0005378 10.22 BGN COL3A1 FBN1 MYH11 MYLK NOTCH1
5 immune system MP:0005387 10.22 BGN COL3A1 FBN1 MFAP5 MYLK NOTCH1
6 digestive/alimentary MP:0005381 10.19 COL3A1 MYH11 MYLK NOTCH1 PRKG1 SMAD3
7 mortality/aging MP:0010768 10.17 BGN COL3A1 EFEMP2 FBN1 LOX MYH11
8 hematopoietic system MP:0005397 10.16 FBN1 MFAP5 NOTCH1 PRKG1 SLC2A10 SMAD3
9 muscle MP:0005369 10.07 ACTA2 BGN COL3A1 EFEMP2 FBN1 LOX
10 craniofacial MP:0005382 10.05 BGN FBN1 NOTCH1 SMAD3 TGFB2 TGFB3
11 integument MP:0010771 10.02 BGN COL3A1 EFEMP2 FBN1 LOX MYH11
12 renal/urinary system MP:0005367 9.76 FBN1 MYH11 MYLK NOTCH1 PRKG1 SLC2A10
13 respiratory system MP:0005388 9.7 COL3A1 EFEMP2 FBN1 LOX MYH11 NOTCH1
14 skeleton MP:0005390 9.36 BGN EFEMP2 FBN1 MFAP5 MYLK NOTCH1

Drugs & Therapeutics for Aortic Aneurysm

Drugs for Aortic Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 264)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198
2
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
3
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
4
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
7
Tranexamic Acid Approved Phase 4 1197-18-8 5526
8
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
9
Nicotine Approved Phase 4 54-11-5 942 89594
10
Iodine Approved, Investigational Phase 4 7553-56-2 807
11
Remifentanil Approved Phase 4 132875-61-7 60815
12
Morphine Approved, Investigational Phase 4 57-27-2 5288826
13
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
14
Atenolol Approved Phase 4 29122-68-7 2249
15
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
16
Atorvastatin Approved Phase 4 134523-00-5 60823
17
Eplerenone Approved Phase 4 107724-20-9 150310 443872
18
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
19
Desflurane Approved Phase 4 57041-67-5 42113
20
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
21
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
22
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
23
Clevidipine Approved, Investigational Phase 4 167221-71-8
24
Histidine Approved, Nutraceutical Phase 4 71-00-1 6274
25
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
26
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
27 Pharmaceutical Solutions Phase 4
28 Hydroxyethyl Starch Derivatives Phase 4
29 Plasma Substitutes Phase 4
30 Blood Substitutes Phase 4
31 Angiotensinogen Phase 4
32 Angiotensin II Type 1 Receptor Blockers Phase 4
33 Giapreza Phase 4
34 Angiotensin Receptor Antagonists Phase 4
35 Methylprednisolone Acetate Phase 4
36 Prednisolone acetate Phase 4
37 Antifibrinolytic Agents Phase 4
38 Tryptophan Phase 4
39 cadexomer iodine Phase 4
40 Narcotics Phase 4
41 Analgesics, Opioid Phase 4
42 Adrenergic beta-1 Receptor Antagonists Phase 4
43 Adrenergic beta-Antagonists Phase 4
44 Adrenergic Antagonists Phase 4
45 Sympatholytics Phase 4
46 Lipid Regulating Agents Phase 4
47 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
48 Hypolipidemic Agents Phase 4
49 Anticholesteremic Agents Phase 4
50 Antigen-Antibody Complex Phase 4

Interventional clinical trials:

(show top 50) (show all 624)
# Name Status NCT ID Phase Drugs
1 Prophylactic Mesh Implantation After Abdominal Aortic Aneurysm Repair. A Prospective, Randomised, Controlled Study Unknown status NCT01353443 Phase 4
2 A Randomised Controlled Trial of the Effectiveness of Acetazolamide in Reducing Cerebrospinal Fluid Pressure for Patients Undergoing Thoracic-abdominal Aortic Repair Unknown status NCT01889498 Phase 4 Acetazolamide
3 The Effect of Immunonutrition on Outcome and Postoperative Recovery in Patients Undergoing Elective Surgical Repair of a Thoraco (Abdominal) Aneurysm Aorta Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
4 Study Using Plasma for Patients Requiring Emergency Surgery: A Randomized Pilot Trial of Early Plasma for Patients Undergoing Emergency Surgery for Hemorrhagic Shock Unknown status NCT01221389 Phase 4 Human Plasma
5 Endovascular Treatment of Thoracic Aortic Aneurysms Using the TALENT Stent Graft System Completed NCT00802984 Phase 4
6 A Clinical Evaluation of the GORE EXCLUDER® Bifurcated Endoprosthesis - Low Permeability in the Primary Treatment of Infrarenal Abdominal Aortic Aneurysms Completed NCT00593814 Phase 4
7 Study of the Effectiveness of Telmisartan in Slowing the Progression of Abdominal Aortic Aneurysms Completed NCT01683084 Phase 4 Telmisartan;Placebo
8 TALENT Endoluminal Stent Graft System for the Treatment of Abdominal Aortic Aneurysms Completed NCT00803075 Phase 4
9 Prevalence of Abdominal Aortic Aneurysm in Patients Undergoing Coronary Angiography Completed NCT01239225 Phase 4
10 CUstodiol Versus RInger: whaT Is the Best Agent? A Randomized Double Blind Trial. Completed NCT02327611 Phase 4 Custodiol;Enriched Ringer's lactate solution
11 Opioid-potentiated Volative Anaesthetic(Sevoflurane)Compared to Remifentanil and Propofol During Abdominal Aortic Aneurysm Surgery Completed NCT00538421 Phase 4 Propofol;Sevoflurane
12 CSP #498 - Open Versus Endovascular Repair (OVER) Trial for Abdominal Aortic Aneurysms Completed NCT00094575 Phase 4
13 Coagulopathy During Surgery for the Repair of Extent 4 Thoraco-Abdominal Aortic Aneurysms - Feasibility Study of the Use of Fibrinogen Concentrate by Infusion in Place of Fresh Frozen Plasma. Completed NCT00994045 Phase 4
14 Transversus Abdominis Plane (TAP) Block in Open Abdominal Aortic Surgery : Randomized Controlled Doubled-blind Trial Comparing Ropivacaine 0.2% Versus Placebo Completed NCT03657979 Phase 4 Ropivacaine;Placebo
15 Comparison of Intravenous Anesthetics and Volatile Anesthetics on Postoperative Cognitive Dysfunction of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities. Completed NCT02107170 Phase 4 Sevoflurane;Propofol;Remifentanil
16 Comparison of High Iodine Concentration Contrast Material (Isovue 370) vs Standard Protocol (Isovue 300) in Thoracoabdominal Aortic Computed Tomographic Angiography (CTA) for Radiation Dose Reduction Completed NCT02291718 Phase 4 Isovue
17 Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial) Completed NCT01904981 Phase 4 Beta-blocker-Atenolol 50mg, PO(peroral), Once daily;Angiotensin receptor blocker-Valsartan 80mg, PO(peroral), Once daily
18 Tranexamic Acid in Major Vascular Surgery. A Randomized Placebo-controlled Trial. Completed NCT02335359 Phase 4 tranexamic acid diluted in 100 ml of saline solution (loading dose);tranexamic acid undiluted (continous infusion);Placebo
19 Randomised Controlled Trial of Effect of Pre-operative Statin Use on Matrix Metalloproteinases (MMP) & Tissue Inhibitors of Matrix Metalloproteinases (TIMP) in Abdominal Aortic Aneurysm (AAA). Completed NCT01062802 Phase 4 Atorvastatin
20 Atorvastatin 80mg Versus Atorvastatin 20mg in Perioperative Vascular Surgery to Evaluate Cardiovascular Outcomes Completed NCT00610545 Phase 4 Atorvastatin;Atorvastatin
21 A Controlled Trial of Effectiveness of a Backward Walking Program in Patients Recovering From an Abdominal Aorta Surgery Completed NCT00819936 Phase 4
22 Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Randomized Clinical Trial Completed NCT02678728 Phase 4 Dexmedetomidine;normal saline
23 A Trial of Telmisartan Prevention of Cardiovascular Disease Completed NCT01075698 Phase 4 Non-ARB (standard therapy);ARB (Telmisartan)
24 Effects of OctaplasLG® on Endothelial Integrity in Patients Undergoing Emergency Surgery for Thoracic Aortic Dissections - a Randomized, Controlled, Single-blinded Investigator-initiated Pilot Trial Completed NCT02253082 Phase 4 OctaplasLG®
25 Impact of Carotid Plaque Screening on Smoking Cessation and Control of Other Cardiovascular Risk Factors: A Randomized Controlled Trial. Completed NCT00548665 Phase 4
26 Randomized Trial of Pulsatile vs Non Pulsatile Perfusion on Short Term Changes in Kidney Function Using an Intra-Aortic Ballooon Pump During Cardioplegic Arrest in Patients Undergoing Myocardial Reperfusion Completed NCT00454428 Phase 4
27 Physician-Initiated PMCF Trial Investigating the BeGraft Peripheral Stent Graft System for the Treatment of Iliac Lesions Completed NCT02211716 Phase 4
28 Eplerenone in the Management of Abdominal Aortic Aneurysms: A Proof-Of-Concept Randomised Controlled Trial Recruiting NCT02345590 Phase 4 Eplerenone
29 Randomized Preventive Vascular Screening Trial of 65-74 Year Old Men in the Central Region of Denmark Recruiting NCT00662480 Phase 4
30 Noninvasive Assessment of Abdominal Aortic Aneurysm (AAA) Wall Structural Integrity and Inflammation as Predictors of Expansion and/or Rupture Recruiting NCT03231397 Phase 4 Assess AAA rupture risk by PET-CTA scans;18F-fludeoxyglucose (FDG)
31 Fast-track in Endovascular Aortic Aneurysm Repair With Desflurane and Sevoflurane: a Randomized Clinical Trial Recruiting NCT03917186 Phase 4 Sevoflurane;Desflurane
32 Pilot Study of of Renal Arterial Sympathetic Denervation by Cryotherapy During Open Surgery for Aortic Aneurysm Active, not recruiting NCT02345603 Phase 4
33 Multicenter, Post-Market Study to Assess Outcomes of Patients Treated With the AFX System Compared to Other EVAR Devices for Endovascular Abdominal Aortic Aneurysm Repair: LEOPARD Enrolling by invitation NCT02407457 Phase 4
34 ACTION-1: ACT Guided Heparinization During Open Abdominal Aortic Aneurysm Repair, a Randomised Trial. Not yet recruiting NCT04061798 Phase 4 ACT guided heparinization
35 Intercostal Nerve Cryoablation for Postoperative Pain Management Not yet recruiting NCT03972397 Phase 4 Bupivacaine liposomal injectable suspension;Patient-controlled analgesia (PCA)
36 Randomized Clinical Trial Comparing Surveillance and Selective Surgical Treatment for Abdominal Aortic Aneurysms Less Than 5.5 cm in Diameter Versus Early Endovascular Treatment Terminated NCT00118573 Phase 4
37 Phase 4 Study of Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic Aneurysms Terminated NCT00409344 Phase 4 Dexmedetomidine
38 Long-term Benefit of Aortic Stent-graft in Patients With Distal Aortic Dissection Terminated NCT01354119 Phase 4
39 A Safety and Efficacy Study of Blood Pressure Control in Acute Aortic Emergencies - A Pilot Study (PROMPT) Terminated NCT01033370 Phase 4 clevidipine.
40 Comparison of a Single Dose Fibrinogen With Placebo and the Number of Blood Transfusions After Ascending Aorta Surgery (FIBTEG Study) Terminated NCT02299947 Phase 4 Haemocomplettan P;Placebo
41 Extensive Type A Dissections and Thoracic/ Thoraco-Abdominal Withdrawn NCT01107366 Phase 4
42 Expertise Based Randomized Controlled Trial of Open Versus Endovascular Repair of Abdominal Aortic Aneurysms: A Pilot Study Unknown status NCT00358085 Phase 3
43 Prospective, Multicenter, Single Arm Phase II Study of the Powerlink 34mm Cuff for the Endovascular Repair of Abdominal Aortic Aneurysms Unknown status NCT00706394 Phase 2, Phase 3
44 Magnetic Resonance Imaging of Aortic Aneurysm Instability Unknown status NCT00794092 Phase 2, Phase 3 Sinerem administration
45 Prophylactic Use of Nesiritide (Brain Natriuretic Peptide, BNP) for the Prevention of Acute Renal Failure in Thoracic Aortic Aneurysm Surgery Patients Unknown status NCT00110201 Phase 3 Nesiritide
46 Efficacy of the Ultrasound-guidedTransversus Abdominis Plane (TAP) Block on Postoperative Pain Control in Open Aortic Abdominal Aneurysm Repair Surgery Unknown status NCT02292667 Phase 3 PCA with Chlorhydrate of Morphine;Acetaminophen
47 Effects of Losartan vs. Nebivolol vs. the Association of Both on the Progression of Aortic Root Dilation in Marfan Syndrome (MFS) With FBN1 Gene Mutations. Unknown status NCT00683124 Phase 3 Losartan and nebivolol;Losartan;Nebivolol
48 A Prospective, Multicenter Study of the Cordis Endovascular QUANTUM LP™ Stent Graft System for the Treatment of Abdominal Aortic Aneurysms (AAA)-FORTRON Completed NCT00233688 Phase 3
49 Evaluation of the Medtronic Vascular Talent Thoracic Stent Graft System for the Treatment of Thoracic Aortic Aneurysms Completed NCT00604799 Phase 2, Phase 3
50 A Study to Assess the Acute Technical Success of Aorfix™ Stent Grafts in the Treatment of Abdominal Aortic and Aorto-Iliac Aneurysm Where a Significant Degree of Vessel Angulation Exists at the Neck of the Aneurysm Completed NCT00442065 Phase 2, Phase 3

Search NIH Clinical Center for Aortic Aneurysm

Inferred drug relations via UMLS 72 / NDF-RT 51 :


trimethaphan camsylate

Cochrane evidence based reviews: aortic aneurysm

Genetic Tests for Aortic Aneurysm

Genetic tests related to Aortic Aneurysm:

# Genetic test Affiliating Genes
1 Aortic Aneurysm 29

Anatomical Context for Aortic Aneurysm

MalaCards organs/tissues related to Aortic Aneurysm:

41
Kidney, Heart, Spinal Cord, Lung, Smooth Muscle, Testes, Endothelial

Publications for Aortic Aneurysm

Articles related to Aortic Aneurysm:

(show top 50) (show all 22479)
# Title Authors PMID Year
1
The Effect of Remote Ischaemic Preconditioning on Arterial Stiffness in Patients Undergoing Vascular Surgery: A Randomised Clinical Trial. 38 17
31126835 2019
2
Open versus Endovascular Repair of Abdominal Aortic Aneurysm. 38 17
31141634 2019
3
Usefulness of ultrasound in the management of aortic dissection. 17
31054559 2018
4
The role of perivascular adipose tissue in the appearance of ectopic adipocytes in the abdominal aortic aneurysmal wall. 38
31250691 2019
5
CNB-001 reduces paraplegia in rabbits following spinal cord ischemia. 38
31397359 2019
6
Sequencing of NOTCH1 gene in an Italian population with bicuspid aortic valve: Preliminary results from the GISSI OUTLIERS VAR study. 38
31330235 2019
7
Regional distribution of delamination strength in ascending thoracic aortic aneurysms. 38
31200336 2019
8
Imatinib prevents elastase-induced abdominal aortic aneurysm progression by regulating macrophage-derived MMP9. 38
31325435 2019
9
Characterizing and Assessing the Impact of Surgery on Healthcare Spending Among Medicare Enrolled Preoperative Super-utilizers. 38
31305286 2019
10
Combined transbrachial and transfemoral strategy to deploy an iliac branch endoprosthesis in the setting of a pre-existing endovascular aortic aneurysm repair. 38
31334406 2019
11
GRADE-Based Recommendations for Surgical Repair of Nonruptured Abdominal Aortic Aneurysm. 38
30961349 2019
12
Clampless aortic punch system for making a large-diameter access route without side-biting clamp: a preliminary study. 38
30612213 2019
13
Long noncoding RNA myocardial infarction associated transcript promotes the development of thoracic aortic by targeting microRNA-145 via the PI3K/Akt signaling pathway. 38
30989723 2019
14
Handmade stent graft fenestration to preserve left subclavian artery in thoracic endovascular aortic repair†. 38
30809647 2019
15
Thoracic wall ischemia after repair of thoracoabdominal aortic aneurysm requiring large microvascular soft tissue reconstruction. 38
31304435 2019
16
Commentary: Hybrid thoracoabdominal aortic aneurysm repair: One step closer with the SPIDER graft. 38
30745053 2019
17
Aortopulmonary fistula related death - forensic implications. 38
31028574 2019
18
Abdominal aortic aneurysm as an IgG4-related disease. 38
31032886 2019
19
Fluoroquinolone Use and the Risk of Collagen-Associated Adverse Events: A Systematic Review and Meta-Analysis. 38
31077091 2019
20
The vasa vasorum reach deep into the human thoracic aorta. 38
31288081 2019
21
Hybrid rescue technique after failure of a standard multibranched stent graft. 38
31334413 2019
22
Impact of hybrid thoracoabdominal aortic repair on visceral and spinal cord perfusion: The new and improved SPIDER-graft. 38
30745044 2019
23
Perigraft seroma penetrating the aortic sac and rupturing into the intraperitoneal cavity. 38
31334404 2019
24
Metformin prescription and aortic aneurysm: systematic review and meta-analysis. 38
30936409 2019
25
Delphi Study to Reach International Consensus Among Vascular Surgeons on Major Arterial Vascular Surgical Complications. 38
31183537 2019
26
Successful hybrid management of a ruptured abdominal aortic aneurysm induced by type II and IIIB endoleaks after endovascular aortic repair. 38
31334410 2019
27
Pleomorphic undifferentiated aortic sarcoma presenting as persistent endoleak after endovascular aneurysm repair. 38
31334403 2019
28
Deployment of stent graft in an excessively higher position above the renal artery induces a flow channel to the aneurysm in chimney endovascular aortic aneurysm repair: an in vitro study. 38
30663032 2019
29
Evaluation of the distribution and progression of intraluminal thrombus in abdominal aortic aneurysms using high-resolution MRI. 38
30694008 2019
30
Novel Machine Learning Approach to Identify Preoperative Risk Factors Associated With Super-Utilization of Medicare Expenditure Following Surgery. 38
31411664 2019
31
Migration and sac expansion as modes of midterm therapeutic failure after endovascular aneurysm sealing: 295 cases at a single center. 38
31405762 2019
32
Expert Opinion on Hostile Neck Definition in Endovascular Treatment Abdominal Aortic Aneurysms (a Delphi consensus). 38
31394211 2019
33
Validation of a preoperative prediction model for mortality within 1 year after endovascular aortic aneurysm repair of intact aneurysms. 38
30922759 2019
34
Systematic review and meta-analysis of elective and urgent late open conversion after failed endovascular aneurysm repair. 38
30956006 2019
35
African Americans are less likely to have elective endovascular repair of abdominal aortic aneurysms. 38
30606666 2019
36
Outcomes of the Repair of 1000 Abdominal Aortic Aneurysms in the Endovascular Era. 38
30802567 2019
37
Viabahn open revascularization technique for renal artery revascularization reduces renal ischemia in thoracoabdominal aortic aneurysm hybrid open-endovascular repair. 38
31394238 2019
38
Fenestrated/Branched Endovascular Aortic Aneurysm Repair Using a Supraceliac Aortic Proximal Seal Zone Versus an Infraceliac Aortic Proximal Seal Zone. 38
31382008 2019
39
The removal of all proximal aneurysmal aortic tissue does not affect anastomotic degeneration after open juxtarenal aortic aneurysm repair. 38
31401116 2019
40
Techniques for Treating Postdissection Thoracoabdominal Aortic Aneurysm: Can Parallel Stent-Grafts Challenge Fenestrated/Branched Technology for Total Endovascular Repair? 38
31402732 2019
41
Abdominal Compartment Syndrome after Surgery for Abdominal Aortic Aneurysm: Subgroups, Risk Factors, and Outcome. 38
31405726 2019
42
Ruptured Abdominal Aortic Aneurysm Treated by Double-Balloon Technique and Endovascular Strategy: Case Series. 38
29491195 2019
43
Thoracic aorta involvement in giant cell arteritis: a case-control analysis of morphological data at diagnosis. 38
31376270 2019
44
Fish intake and risk of mortality due to aortic dissection and aneurysm: A pooled analysis of the Japan cohort consortium. 38
30172657 2019
45
Regional anesthesia for vascular surgery: does the anesthetic choice influence outcome? 38
31415047 2019
46
New Large Animal Model for Aortic Aneurysms in the Viscerorenal Segment. 38
30933829 2019
47
Spontaneous Retroperitoneal and Rectus Sheath Hemorrhage-Management, Risk Factors and Outcomes. 38
30963204 2019
48
Aortic arch replacement with frozen elephant trunk technique - a single-center study. 38
31370864 2019
49
Late open conversion after thoracic endovascular aortic repair. 38
30691702 2019
50
Inpatient prevalence, burden and comorbidity of Takayasu's arteritis: Nationwide inpatient sample 2013-2014. 38
30577953 2019

Variations for Aortic Aneurysm

ClinVar genetic disease variations for Aortic Aneurysm:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 FBN1 NM_000138.4(FBN1): c.7754T> C (p.Ile2585Thr) single nucleotide variant Pathogenic/Likely pathogenic rs727503054 15:48712949-48712949 15:48420752-48420752
2 TGFB2 NM_003238.5(TGFB2): c.356C> T (p.Pro119Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs149533093 1:218578520-218578520 1:218405178-218405178
3 COL3A1 NM_000090.3(COL3A1): c.505C> T (p.Leu169Phe) single nucleotide variant Conflicting interpretations of pathogenicity rs111391222 2:189851842-189851842 2:188987116-188987116
4 MYH11 NM_002474.3(MYH11): c.4942C> T (p.Arg1648Cys) single nucleotide variant Uncertain significance rs369409348 16:15814019-15814019 16:15720162-15720162

Expression for Aortic Aneurysm

Search GEO for disease gene expression data for Aortic Aneurysm.

Pathways for Aortic Aneurysm

Pathways related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
2
Show member pathways
13.2 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
3
Show member pathways
13.2 TGFBR2 TGFBR1 TGFB3 TGFB2 MYLK MYH11
4
Show member pathways
13.06 TGFBR1 TGFB3 TGFB2 FBN1 ELN EFEMP2
5
Show member pathways
13.04 TGFBR2 TGFBR1 SMAD3 PRKG1 COL3A1 ACTA2
6
Show member pathways
12.96 TGFBR2 TGFBR1 TGFB3 TGFB2 PRKG1 MYH11
7
Show member pathways
12.89 TGFBR2 TGFBR1 TGFB3 TGFB2 MYLK ACTA2
8 12.87 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
9
Show member pathways
12.85 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
10
Show member pathways
12.79 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
11
Show member pathways
12.64 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
12
Show member pathways
12.51 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
13 12.4 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
14 12.29 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
15
Show member pathways
12.26 MYLK MYH11 FBN1 ELN EFEMP2 COL3A1
16
Show member pathways
12.26 TGFB3 TGFB2 MFAP5 LOX FBN1 ELN
17
Show member pathways
12.23 TGFBR2 TGFBR1 TGFB2 SMAD3
18 12.23 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
19 12.21 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
20 12.18 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
21 12.12 TGFBR1 SMAD3 MYLK ACTA2
22
Show member pathways
12.11 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
23
Show member pathways
12.09 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
24
Show member pathways
12.07 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
25 11.93 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 ACTA2
26 11.9 TGFBR1 TGFB3 TGFB2 NOTCH1
27 11.89 TGFB3 TGFB2 COL3A1
28 11.87 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
29
Show member pathways
11.85 TGFBR2 TGFBR1 SMAD3
30 11.85 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
31
Show member pathways
11.83 TGFBR2 TGFBR1 SMAD3 LOX
32 11.74 TGFBR2 TGFBR1 SMAD3
33 11.73 TGFBR2 TGFBR1 SMAD3
34 11.73 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 COL3A1
35
Show member pathways
11.72 TGFBR2 TGFBR1 SMAD3
36 11.63 TGFBR2 TGFBR1 SMAD3
37 11.62 TGFB3 TGFB2 BGN
38
Show member pathways
11.61 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
39 11.61 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 ACTA2
40 11.59 TGFBR2 TGFBR1 TGFB3 SMAD3
41 11.55 TGFBR2 TGFBR1 TGFB2
42 11.5 TGFBR2 TGFBR1 TGFB3 TGFB2
43 11.4 MYLK MYH11 ACTA2
44 11.39 TGFBR2 TGFBR1 TGFB3 TGFB2 MYLK ACTA2
45
Show member pathways
11.27 TGFBR2 TGFBR1 TGFB3
46 11.25 TGFBR2 TGFBR1 TGFB3
47 11.16 TGFBR2 TGFBR1 SMAD3 FBN1
48 11.14 TGFBR2 TGFBR1 SMAD3
49 11.05 TGFB3 TGFB2 MYLK FBN1 ELN EFEMP2
50 11.03 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3

GO Terms for Aortic Aneurysm

Cellular components related to Aortic Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 TGFB3 TGFB2 NOTCH1 MFAP5 LOX FBN1
2 cell surface GO:0009986 9.77 TGFBR2 TGFBR1 TGFB3 NOTCH1 BGN
3 receptor complex GO:0043235 9.56 TGFBR2 TGFBR1 SMAD3 NOTCH1
4 extracellular matrix GO:0031012 9.43 MFAP5 LOX FBN1 ELN COL3A1 BGN
5 microfibril GO:0001527 9.32 MFAP5 FBN1
6 collagen-containing extracellular matrix GO:0062023 9.17 TGFB3 TGFB2 MFAP5 FBN1 ELN COL3A1

Biological processes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.97 TGFBR1 SMAD3 NOTCH1 MYLK CDKN2B-AS1
2 extracellular matrix organization GO:0030198 9.97 MFAP5 FBN1 ELN COL3A1 BGN
3 regulation of cell proliferation GO:0042127 9.96 TGFBR2 TGFB3 TGFB2 NOTCH1
4 response to hypoxia GO:0001666 9.96 TGFBR2 TGFB3 TGFB2 SMAD3
5 in utero embryonic development GO:0001701 9.96 TGFBR2 TGFBR1 TGFB3 SMAD3 NOTCH1
6 cell cycle arrest GO:0007050 9.92 TGFBR1 TGFB2 SMAD3 NOTCH1
7 kidney development GO:0001822 9.9 TGFBR1 TGFB2 FBN1
8 muscle contraction GO:0006936 9.9 MYLK MYH11 ACTA2
9 lung development GO:0030324 9.89 TGFBR2 NOTCH1 LOX
10 cellular response to transforming growth factor beta stimulus GO:0071560 9.85 TGFBR1 SMAD3 FBN1
11 heart looping GO:0001947 9.85 TGFBR2 SMAD3 NOTCH1
12 SMAD protein signal transduction GO:0060395 9.85 TGFB3 TGFB2 SMAD3
13 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.85 TGFBR2 TGFBR1 TGFB3 SMAD3
14 skeletal system development GO:0001501 9.85 TGFBR1 TGFB2 SMAD3 FBN1 COL3A1
15 outflow tract morphogenesis GO:0003151 9.84 TGFBR2 NOTCH1 ELN
16 positive regulation of stress fiber assembly GO:0051496 9.83 TGFBR1 TGFB3 SMAD3
17 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.83 TGFBR1 TGFB3 TGFB2
18 heart development GO:0007507 9.8 TGFBR2 TGFBR1 TGFB2 NOTCH1 LOX FBN1
19 epithelial to mesenchymal transition GO:0001837 9.79 TGFBR1 TGFB2 NOTCH1
20 embryonic cranial skeleton morphogenesis GO:0048701 9.79 TGFBR2 TGFBR1 SMAD3
21 digestive tract development GO:0048565 9.77 TGFBR2 TGFB3 COL3A1
22 cell-cell junction organization GO:0045216 9.76 TGFB3 TGFB2 SMAD3
23 smooth muscle contraction GO:0006939 9.72 MYLK MYH11
24 endocardial cushion morphogenesis GO:0003203 9.72 TGFB2 NOTCH1
25 activin receptor signaling pathway GO:0032924 9.72 TGFBR1 SMAD3
26 regulation of epithelial cell proliferation GO:0050678 9.72 SMAD3 NOTCH1
27 pulmonary valve morphogenesis GO:0003184 9.71 TGFB2 NOTCH1
28 negative regulation of immune response GO:0050777 9.71 TGFB2 COL3A1
29 cardiac muscle cell proliferation GO:0060038 9.71 TGFB2 NOTCH1
30 ventricular trabecula myocardium morphogenesis GO:0003222 9.71 TGFBR1 TGFB2 NOTCH1
31 collagen fibril organization GO:0030199 9.71 TGFBR1 TGFB2 LOX COL3A1
32 supramolecular fiber organization GO:0097435 9.7 MFAP5 COL3A1
33 positive regulation of SMAD protein signal transduction GO:0060391 9.7 TGFBR1 TGFB3
34 somatic stem cell division GO:0048103 9.7 TGFB2 NOTCH1
35 salivary gland morphogenesis GO:0007435 9.7 TGFB3 TGFB2
36 secondary palate development GO:0062009 9.7 TGFBR2 TGFB3 TGFB2
37 response to cholesterol GO:0070723 9.69 TGFBR2 TGFBR1
38 membranous septum morphogenesis GO:0003149 9.69 TGFBR2 TGFB2
39 cardiac left ventricle morphogenesis GO:0003214 9.69 TGFBR2 NOTCH1
40 pathway-restricted SMAD protein phosphorylation GO:0060389 9.69 TGFBR2 TGFBR1 TGFB2
41 coronary artery morphogenesis GO:0060982 9.68 TGFBR1 NOTCH1
42 cardiac epithelial to mesenchymal transition GO:0060317 9.67 TGFBR1 TGFB2 NOTCH1
43 ventricular septum morphogenesis GO:0060412 9.67 TGFBR2 TGFBR1 TGFB2 NOTCH1
44 negative regulation of macrophage cytokine production GO:0010936 9.65 TGFB3 TGFB2
45 atrioventricular valve morphogenesis GO:0003181 9.65 TGFBR2 TGFB2 NOTCH1
46 aorta smooth muscle tissue morphogenesis GO:0060414 9.64 MYLK COL3A1
47 regulation of transforming growth factor beta2 production GO:0032909 9.64 TGFB2 SMAD3
48 glomerular mesangial cell development GO:0072144 9.63 NOTCH1 ACTA2
49 endocardial cushion fusion GO:0003274 9.63 TGFBR2 TGFB2
50 transforming growth factor beta receptor signaling pathway GO:0007179 9.63 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 COL3A1

Molecular functions related to Aortic Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta receptor binding GO:0005160 9.54 TGFB3 TGFB2 SMAD3
2 transforming growth factor beta-activated receptor activity GO:0005024 9.48 TGFBR2 TGFBR1
3 type I transforming growth factor beta receptor binding GO:0034713 9.46 TGFBR2 TGFB3
4 SMAD binding GO:0046332 9.46 TGFBR2 TGFBR1 SMAD3 COL3A1
5 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.43 TGFBR2 TGFBR1
6 transforming growth factor beta binding GO:0050431 9.43 TGFBR2 TGFBR1 TGFB3
7 extracellular matrix constituent conferring elasticity GO:0030023 9.4 FBN1 ELN
8 type III transforming growth factor beta receptor binding GO:0034714 9.32 TGFB3 TGFB2
9 type II transforming growth factor beta receptor binding GO:0005114 9.13 TGFBR1 TGFB3 TGFB2
10 extracellular matrix structural constituent GO:0005201 9.1 MFAP5 FBN1 ELN EFEMP2 COL3A1 BGN

Sources for Aortic Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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