MCID: ART016
MIFTS: 69

Aortic Aneurysm

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Aortic Aneurysm

MalaCards integrated aliases for Aortic Aneurysm:

Name: Aortic Aneurysm 12 74 29 6 42 3 43 15 17 71
Thoracoabdominal Aortic Aneurysm, Ruptured 12 71 32
Aortic Rupture 43 17 71
Abdominal Aortic Aneurysm, Ruptured 12 32
Ruptured Abdominal Aortic Aneurysm 12 71
Thoracic Aortic Aneurysm, Ruptured 12 32
Ruptured Thoracic Aortic Aneurysm 12 71
Aortic Aneurysm Without Mention of Rupture Nos 71
Thoracic Aortic Aneurysm Which Has Ruptured 12
Ruptured Thoracoabdominal Aortic Aneurysm 12
Ruptured Thoracic Aneurysm 12
Aortic Aneurysm, Ruptured 71
Ruptured Aortic Aneurysm 12
Aortic Aneurysms 15

Classifications:



External Ids:

Disease Ontology 12 DOID:3627
UMLS 71 C0003486 C0003496 C0265010 more

Summaries for Aortic Aneurysm

MedlinePlus : 42 An aneurysm is a bulge or "ballooning" in the wall of an artery. Arteries are blood vessels that carry oxygen-rich blood from the heart to other parts of the body. If an aneurysm grows large, it can burst and cause dangerous bleeding or even death. Most aneurysms are in the aorta, the main artery that runs from the heart through the chest and abdomen. There are two types of aortic aneurysm: Thoracic aortic aneurysms (TAA) - these occur in the part of the aorta running through the chest Abdominal aortic aneurysms (AAA) - these occur in the part of the aorta running through the abdomen Most aneurysms are found during tests done for other reasons. Some people are at high risk for aneurysms. It is important for them to get screening, because aneurysms can develop and become large before causing any symptoms. Screening is recommended for people between the ages of 65 and 75 if they have a family history, or if they are men who have smoked. Doctors use imaging tests to find aneurysms. Medicines and surgery are the two main treatments. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Aortic Aneurysm, also known as thoracoabdominal aortic aneurysm, ruptured, is related to aortic aneurysm, familial abdominal, 1 and aortic aneurysm, familial thoracic 6, and has symptoms including edema, chest pain and angina pectoris. An important gene associated with Aortic Aneurysm is FBN1 (Fibrillin 1), and among its related pathways/superpathways are ERK Signaling and PAK Pathway. The drugs Eplerenone and Acetazolamide have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and spinal cord, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size.

CDC : 3 An aortic aneurysm is a balloon-like bulge in the aorta, the large artery that carries blood from the heart through the chest and torso. Aortic aneurysms work in two ways: • The force of blood pumping can split the layers of the artery wall, allowing blood to leak in between them. This process is called a dissection. • The aneurysm can burst completely, causing bleeding inside the body. This is called a rupture. • Dissections and ruptures are the cause of most deaths from aortic aneurysms.

Wikipedia : 74 An aortic aneurysm is an enlargement (dilatation) of the aorta to greater than 1.5 times normal size.... more...

Related Diseases for Aortic Aneurysm

Diseases related to Aortic Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 910)
# Related Disease Score Top Affiliating Genes
1 aortic aneurysm, familial abdominal, 1 35.2 FBN1 ELN CDKN2B-AS1
2 aortic aneurysm, familial thoracic 6 34.9 TGFBR1 SLC2A10 MYLK MYH11 ACTA2
3 familial abdominal aortic aneurysm 34.7 MYLK FBN1 ELN COL3A1
4 aortic aneurysm, familial thoracic 2 34.5 SLC2A10 FBN2 FBN1 COL3A1 ACTA2
5 familial thoracic aortic aneurysm and aortic dissection 33.8 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
6 loeys-dietz syndrome 1 33.7 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
7 autosomal recessive cutis laxa type i 33.3 SLC2A10 FBN1 ELN EFEMP2
8 cutis laxa, autosomal dominant 1 33.1 TGFBR2 TGFBR1 SLC2A10 FBN1 ELN EFEMP2
9 loeys-dietz syndrome 5 33.0 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 FBN1
10 aortic aneurysm, familial thoracic 1 33.0 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
11 patent ductus arteriosus 1 33.0 TGFBR2 TGFBR1 NOTCH1 MYH11 FBN1 ELN
12 loeys-dietz syndrome 33.0 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
13 loeys-dietz syndrome 4 32.9 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
14 marfan syndrome 32.7 TGFBR2 TGFBR1 TGFB2 NOTCH1 MYLK MYH11
15 loeys-dietz syndrome 3 32.4 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
16 aneurysm 32.2 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
17 aortic valve insufficiency 31.6 TGFBR2 TGFBR1 MYH11 FBN1 ELN EFEMP2
18 aortic dissection 31.6 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 PRKG1
19 inguinal hernia 31.5 LOX FBN1 ELN
20 ehlers-danlos syndrome 31.2 TGFBR1 SLC2A10 MYH11 FBN2 FBN1 ELN
21 aortic valve disease 2 31.1 NOTCH1 FBN1 ELN
22 ehlers-danlos syndrome, vascular type 31.0 ELN COL3A1
23 aortic disease 30.9 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 PRKG1
24 cutis laxa 30.9 LOX FBN1 ELN EFEMP2
25 telangiectasis 30.9 TGFBR1 FBN1 ELN
26 tetralogy of fallot 30.9 NOTCH1 MYH11 FBN1 ELN
27 pulmonary hypertension 30.9 TGFBR2 TGFBR1 SMAD3 PRKG1 ACTA2
28 supravalvular aortic stenosis 30.8 FBN1 ELN EFEMP2
29 craniosynostosis 30.8 TGFBR2 TGFBR1 SMAD3 FBN1
30 varicose veins 30.8 FBN1 ELN COL3A1
31 scoliosis 30.8 TGFBR2 TGFB2 LOX FBN2 FBN1 ELN
32 moyamoya disease 1 30.7 MYLK MYH11 ELN ACTA2
33 mitral valve disease 30.7 TGFB3 TGFB2 FBN1 ELN
34 hereditary hemorrhagic telangiectasia 30.6 TGFBR2 TGFBR1 TGFB2
35 exfoliation syndrome 30.6 LOX FBN1 ELN
36 heritable thoracic aortic disease 30.5 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 PRKG1
37 atrial heart septal defect 30.5 NOTCH1 FBN1 ELN
38 pseudoxanthoma elasticum 30.5 MYH11 FBN1 ELN
39 intracranial aneurysm 30.5 TGFBR2 TGFBR1 TGFB2 LOX FBN2 ELN
40 aortic valve disease 1 30.4 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
41 collagen disease 30.4 TGFBR2 TGFBR1 FBN1 ELN COL3A1 ACTA2
42 arterial tortuosity syndrome 30.4 TGFBR2 TGFBR1 TGFB2 SMAD3 SLC2A10 MYH11
43 occipital horn syndrome 30.3 LOX ELN EFEMP2
44 brittle bone disorder 30.3 FBN1 ELN COL3A1
45 bladder diverticulum 30.2 SLC2A10 LOX ELN EFEMP2
46 intraocular pressure quantitative trait locus 30.2 TGFB2 FBN1 ELN CDKN2B-AS1
47 connective tissue disease 30.2 TGFBR2 TGFBR1 TGFB2 SMAD3 PRKG1 NOTCH1
48 pancreatic adenocarcinoma 30.1 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
49 cerebral arterial disease 30.0 ELN COL3A1 CDKN2B-AS1 ACTA2
50 glaucoma, primary open angle 30.0 TGFB2 FBN1 ELN CDKN2B-AS1

Comorbidity relations with Aortic Aneurysm via Phenotypic Disease Network (PDN): (show all 13)


Acute Cystitis Acute Kidney Failure
Acute Vascular Insufficiency of Intestine Aortic Valve Disease 1
Cardiac Arrest Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Paralytic Ileus Peripheral Vascular Disease
Respiratory Failure

Graphical network of the top 20 diseases related to Aortic Aneurysm:



Diseases related to Aortic Aneurysm

Symptoms & Phenotypes for Aortic Aneurysm

UMLS symptoms related to Aortic Aneurysm:


edema, chest pain, angina pectoris

GenomeRNAi Phenotypes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00107-A-1 9.92 TGFBR2
2 Decreased viability GR00221-A-1 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
3 Decreased viability GR00221-A-2 9.92 COL3A1 PRKG1
4 Decreased viability GR00221-A-3 9.92 TGFBR2
5 Decreased viability GR00221-A-4 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
6 Decreased viability GR00249-S 9.92 MYLK TGFBR1 TGFBR2
7 Decreased viability GR00301-A 9.92 PRKG1
8 Decreased viability GR00402-S-2 9.92 TGFBR1 TGFBR2

MGI Mouse Phenotypes related to Aortic Aneurysm:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.45 ACTA2 COL3A1 EFEMP2 FBN1 FBN2 LOX
2 cellular MP:0005384 10.29 COL3A1 EFEMP2 FBN1 FBN2 MYH11 NOTCH1
3 hematopoietic system MP:0005397 10.27 COL3A1 FBN1 FBN2 LOX MFAP5 NOTCH1
4 homeostasis/metabolism MP:0005376 10.25 COL3A1 FBN1 FBN2 LOX MYH11 MYLK
5 immune system MP:0005387 10.25 COL3A1 FBN1 FBN2 LOX MFAP5 MYLK
6 digestive/alimentary MP:0005381 10.18 COL3A1 MYH11 MYLK NOTCH1 PRKG1 SMAD3
7 mortality/aging MP:0010768 10.17 COL3A1 EFEMP2 FBN1 FBN2 LOX MYH11
8 integument MP:0010771 10.07 COL3A1 EFEMP2 FBN1 FBN2 LOX MYH11
9 muscle MP:0005369 10.07 ACTA2 COL3A1 EFEMP2 FBN1 FBN2 LOX
10 craniofacial MP:0005382 10.04 FBN1 FBN2 NOTCH1 SMAD3 TGFB2 TGFB3
11 renal/urinary system MP:0005367 9.85 FBN1 FBN2 MYH11 MYLK NOTCH1 PRKG1
12 respiratory system MP:0005388 9.73 COL3A1 EFEMP2 FBN1 FBN2 LOX MYH11
13 skeleton MP:0005390 9.4 EFEMP2 FBN1 FBN2 LOX MFAP5 MYLK

Drugs & Therapeutics for Aortic Aneurysm

Drugs for Aortic Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 269)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Eplerenone Approved Phase 4 107724-20-9 150310 443872
2
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
3
Atenolol Approved Phase 4 29122-68-7 2249
4
Angiotensin II Approved, Investigational Phase 4 4474-91-3, 11128-99-7, 68521-88-0 172198
5
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
6
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
7
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
8
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
9
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
10 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
11
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
12
Nicotine Approved Phase 4 54-11-5 942 89594
13
Tranexamic Acid Approved Phase 4 1197-18-8 5526
14
Iodine Approved, Investigational Phase 4 7553-56-2 807
15
Remifentanil Approved Phase 4 132875-61-7 60815
16
Morphine Approved, Investigational Phase 4 57-27-2 5288826
17
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
18
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
19
Atorvastatin Approved Phase 4 134523-00-5 60823
20
Iron Approved, Experimental Phase 4 15438-31-0, 7439-89-6 27284 23925
21
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
22
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
23
Desflurane Approved Phase 4 57041-67-5 42113
24
Adalimumab Approved Phase 4 331731-18-1 16219006
25
Methotrexate Approved Phase 4 59-05-2, 1959-05-2 126941
26
leucovorin Approved Phase 4 58-05-9 6006 143
27
Tofacitinib Approved, Investigational Phase 4 477600-75-2
28
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
29
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
30
Clevidipine Approved, Investigational Phase 4 167221-71-8
31
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
32
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
33 Pharmaceutical Solutions Phase 4
34 Mineralocorticoids Phase 4
35 Mineralocorticoid Receptor Antagonists Phase 4
36 Diuretics, Potassium Sparing Phase 4
37 Anticonvulsants Phase 4
38 Carbonic Anhydrase Inhibitors Phase 4
39 Hydroxyethyl Starch Derivatives Phase 4
40 Adrenergic beta-1 Receptor Antagonists Phase 4
41 Adrenergic Antagonists Phase 4
42 Sympatholytics Phase 4
43 Adrenergic beta-Antagonists Phase 4
44 Angiotensin II Type 1 Receptor Blockers Phase 4
45 Angiotensinogen Phase 4
46 Angiotensin Receptor Antagonists Phase 4
47 Giapreza Phase 4
48 Methylprednisolone Acetate Phase 4
49 Coagulants Phase 4
50 Antifibrinolytic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 677)
# Name Status NCT ID Phase Drugs
1 Eplerenone in the Management of Abdominal Aortic Aneurysms: A Proof-Of-Concept Randomised Controlled Trial Unknown status NCT02345590 Phase 4 Eplerenone
2 Prophylactic Mesh Implantation After Abdominal Aortic Aneurysm Repair. A Prospective, Randomised, Controlled Study Unknown status NCT01353443 Phase 4
3 A Randomised Controlled Trial of the Effectiveness of Acetazolamide in Reducing Cerebrospinal Fluid Pressure for Patients Undergoing Thoracic-abdominal Aortic Repair Unknown status NCT01889498 Phase 4 Acetazolamide
4 The Effect of Immunonutrition on Outcome and Postoperative Recovery in Patients Undergoing Elective Surgical Repair of a Thoraco (Abdominal) Aneurysm Aorta Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
5 Study Using Plasma for Patients Requiring Emergency Surgery: A Randomized Pilot Trial of Early Plasma for Patients Undergoing Emergency Surgery for Hemorrhagic Shock Unknown status NCT01221389 Phase 4 Human Plasma
6 Endovascular Treatment of Thoracic Aortic Aneurysms Using the TALENT Stent Graft System Completed NCT00802984 Phase 4
7 A Clinical Evaluation of the GORE EXCLUDER® Bifurcated Endoprosthesis - Low Permeability in the Primary Treatment of Infrarenal Abdominal Aortic Aneurysms Completed NCT00593814 Phase 4
8 Study of the Effectiveness of Telmisartan in Slowing the Progression of Abdominal Aortic Aneurysms Completed NCT01683084 Phase 4 Telmisartan;Placebo
9 TALENT Endoluminal Stent Graft System for the Treatment of Abdominal Aortic Aneurysms Completed NCT00803075 Phase 4
10 Prevalence of Abdominal Aortic Aneurysm in Patients Undergoing Coronary Angiography Completed NCT01239225 Phase 4
11 CUstodiol Versus RInger: whaT Is the Best Agent? A Randomized Double Blind Trial. Completed NCT02327611 Phase 4 Custodiol;Enriched Ringer's lactate solution
12 Opioid-potentiated Volative Anaesthetic(Sevoflurane)Compared to Remifentanil and Propofol During Abdominal Aortic Aneurysm Surgery Completed NCT00538421 Phase 4 Propofol;Sevoflurane
13 CSP #498 - Open Versus Endovascular Repair (OVER) Trial for Abdominal Aortic Aneurysms Completed NCT00094575 Phase 4
14 Noninvasive Assessment of Abdominal Aortic Aneurysm (AAA) Wall Structural Integrity and Inflammation as Predictors of Expansion and/or Rupture Completed NCT03231397 Phase 4 Assess AAA rupture risk by PET-CTA scans;18F-fludeoxyglucose (FDG)
15 Coagulopathy During Surgery for the Repair of Extent 4 Thoraco-Abdominal Aortic Aneurysms - Feasibility Study of the Use of Fibrinogen Concentrate by Infusion in Place of Fresh Frozen Plasma. Completed NCT00994045 Phase 4
16 Transversus Abdominis Plane (TAP) Block in Open Abdominal Aortic Surgery : Randomized Controlled Doubled-blind Trial Comparing Ropivacaine 0.2% Versus Placebo Completed NCT03657979 Phase 4 Ropivacaine;Placebo
17 Comparison of Intravenous Anesthetics and Volatile Anesthetics on Postoperative Cognitive Dysfunction of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities. Completed NCT02107170 Phase 4 Sevoflurane;Propofol;Remifentanil
18 Comparison of High Iodine Concentration Contrast Material (Isovue 370) vs Standard Protocol (Isovue 300) in Thoracoabdominal Aortic Computed Tomographic Angiography (CTA) for Radiation Dose Reduction Completed NCT02291718 Phase 4 Isovue
19 Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial) Completed NCT01904981 Phase 4 Beta-blocker-Atenolol 50mg, PO(peroral), Once daily;Angiotensin receptor blocker-Valsartan 80mg, PO(peroral), Once daily
20 Tranexamic Acid in Major Vascular Surgery. A Randomized Placebo-controlled Trial. Completed NCT02335359 Phase 4 tranexamic acid diluted in 100 ml of saline solution (loading dose);tranexamic acid undiluted (continous infusion);Placebo
21 Randomised Controlled Trial of Effect of Pre-operative Statin Use on Matrix Metalloproteinases (MMP) & Tissue Inhibitors of Matrix Metalloproteinases (TIMP) in Abdominal Aortic Aneurysm (AAA). Completed NCT01062802 Phase 4 Atorvastatin
22 A Controlled Trial of Effectiveness of a Backward Walking Program in Patients Recovering From an Abdominal Aorta Surgery Completed NCT00819936 Phase 4
23 Atorvastatin 80mg Versus Atorvastatin 20mg in Perioperative Vascular Surgery to Evaluate Cardiovascular Outcomes Completed NCT00610545 Phase 4 Atorvastatin;Atorvastatin
24 Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Randomized Clinical Trial Completed NCT02678728 Phase 4 Dexmedetomidine;normal saline
25 A Trial of Telmisartan Prevention of Cardiovascular Disease Completed NCT01075698 Phase 4 Non-ARB (standard therapy);ARB (Telmisartan)
26 Effects of OctaplasLG® on Endothelial Integrity in Patients Undergoing Emergency Surgery for Thoracic Aortic Dissections - a Randomized, Controlled, Single-blinded Investigator-initiated Pilot Trial Completed NCT02253082 Phase 4 OctaplasLG®
27 Impact of Carotid Plaque Screening on Smoking Cessation and Control of Other Cardiovascular Risk Factors: A Randomized Controlled Trial. Completed NCT00548665 Phase 4
28 Randomized Trial of Pulsatile vs Non Pulsatile Perfusion on Short Term Changes in Kidney Function Using an Intra-Aortic Ballooon Pump During Cardioplegic Arrest in Patients Undergoing Myocardial Reperfusion Completed NCT00454428 Phase 4
29 Physician-Initiated PMCF Trial Investigating the BeGraft Peripheral Stent Graft System for the Treatment of Iliac Lesions Completed NCT02211716 Phase 4
30 Randomized Preventive Vascular Screening Trial of 65-74 Year Old Men in the Central Region of Denmark Recruiting NCT00662480 Phase 4
31 Fast-track in Endovascular Aortic Aneurysm Repair With Desflurane and Sevoflurane: a Randomized Clinical Trial Recruiting NCT03917186 Phase 4 Sevoflurane;Desflurane
32 A Phase IV Double-blind, Randomised, Parallel Group Comparison of the Efficacy and Safety of Preoperative Intravenous Ferric Carboxymaltose and Placebo in the Treatment of Patients Undergoing Elective or Urgent Cardiac Surgery Recruiting NCT03574311 Phase 4 Ferric carboxymaltose
33 ACTION-1: ACT Guided Heparinization During Open Abdominal Aortic Aneurysm Repair, a Randomised Trial. Recruiting NCT04061798 Phase 4 ACT guided heparinization;5 000 IU of heparin
34 A Pilot Study in the Treatment of Severe Patients With Takayasu Arteritis With Tocilizumab and Adalimumab, Based on ECTA Cohort Recruiting NCT04300686 Phase 4
35 Randomized Open-label Study in Mild and Moderate Patients With Takayasu Arteritis Between Methotrexate and Tofacitinib Based on the ECTA Cohort. Recruiting NCT04299971 Phase 4 Methotrexate Tablets;Tofacitinib tablet
36 Pilot Study of of Renal Arterial Sympathetic Denervation by Cryotherapy During Open Surgery for Aortic Aneurysm Active, not recruiting NCT02345603 Phase 4
37 Intercostal Nerve Cryoablation for Postoperative Pain Management Not yet recruiting NCT03972397 Phase 4 Bupivacaine liposomal injectable suspension;Patient-controlled analgesia (PCA)
38 Randomized Clinical Trial Comparing Surveillance and Selective Surgical Treatment for Abdominal Aortic Aneurysms Less Than 5.5 cm in Diameter Versus Early Endovascular Treatment Terminated NCT00118573 Phase 4
39 Phase 4 Study of Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic Aneurysms Terminated NCT00409344 Phase 4 Dexmedetomidine
40 Long-term Benefit of Aortic Stent-graft in Patients With Distal Aortic Dissection Terminated NCT01354119 Phase 4
41 A Safety and Efficacy Study of Blood Pressure Control in Acute Aortic Emergencies - A Pilot Study (PROMPT) Terminated NCT01033370 Phase 4 clevidipine.
42 Comparison of a Single Dose Fibrinogen With Placebo and the Number of Blood Transfusions After Ascending Aorta Surgery (FIBTEG Study) Terminated NCT02299947 Phase 4 Haemocomplettan P;Placebo
43 Extensive Type A Dissections and Thoracic/ Thoraco-Abdominal Withdrawn NCT01107366 Phase 4
44 Expertise Based Randomized Controlled Trial of Open Versus Endovascular Repair of Abdominal Aortic Aneurysms: A Pilot Study Unknown status NCT00358085 Phase 3
45 Prospective, Multicenter, Single Arm Phase II Study of the Powerlink 34mm Cuff for the Endovascular Repair of Abdominal Aortic Aneurysms Unknown status NCT00706394 Phase 2, Phase 3
46 Magnetic Resonance Imaging of Aortic Aneurysm Instability Unknown status NCT00794092 Phase 2, Phase 3 Sinerem administration
47 Prophylactic Use of Nesiritide (Brain Natriuretic Peptide, BNP) for the Prevention of Acute Renal Failure in Thoracic Aortic Aneurysm Surgery Patients Unknown status NCT00110201 Phase 3 Nesiritide
48 Efficacy of the Ultrasound-guidedTransversus Abdominis Plane (TAP) Block on Postoperative Pain Control in Open Aortic Abdominal Aneurysm Repair Surgery Unknown status NCT02292667 Phase 3 PCA with Chlorhydrate of Morphine;Acetaminophen
49 Effects of Losartan vs. Nebivolol vs. the Association of Both on the Progression of Aortic Root Dilation in Marfan Syndrome (MFS) With FBN1 Gene Mutations. Unknown status NCT00683124 Phase 3 Losartan and nebivolol;Losartan;Nebivolol
50 A Prospective, Multicenter Study of the Cordis Endovascular QUANTUM LP™ Stent Graft System for the Treatment of Abdominal Aortic Aneurysms (AAA)-FORTRON Completed NCT00233688 Phase 3

Search NIH Clinical Center for Aortic Aneurysm

Inferred drug relations via UMLS 71 / NDF-RT 50 :


trimethaphan camsylate

Cochrane evidence based reviews: aortic aneurysm

Genetic Tests for Aortic Aneurysm

Genetic tests related to Aortic Aneurysm:

# Genetic test Affiliating Genes
1 Aortic Aneurysm 29

Anatomical Context for Aortic Aneurysm

MalaCards organs/tissues related to Aortic Aneurysm:

40
Kidney, Heart, Spinal Cord, Smooth Muscle, Lung, Testes, Endothelial

Publications for Aortic Aneurysm

Articles related to Aortic Aneurysm:

(show top 50) (show all 23573)
# Title Authors PMID Year
1
MMPs and ADAMs/ADAMTS inhibition therapy of abdominal aortic aneurysm. 61 42
32283055 2020
2
Effect of Doxycycline on Aneurysm Growth Among Patients With Small Infrarenal Abdominal Aortic Aneurysms: A Randomized Clinical Trial. 61 42
32453369 2020
3
Gentamicin Containing Collagen Implants and Groin Wound Infections in Vascular Surgery: A Prospective Randomised Controlled Multicentre Trial. 42
32094049 2020
4
TRPV1 inhibits smooth muscle cell phenotype switching in a mouse model of abdominal aortic aneurysm. 61
32079471 2020
5
Macrophage stimulating 1-induced inflammation response promotes aortic aneurysm formation through triggering endothelial cells death and activating the NF-κB signaling pathway. 61
32156191 2020
6
Experimental abdominal aortic aneurysm growth is inhibited by blocking the JAK2/STAT3 pathway. 61
32334849 2020
7
Is There a Relationship Between Stress in Walls of Abdominal Aortic Aneurysm and Symptoms? 61
32222592 2020
8
Novel Findings on SPECT-CT Tc-99 Sestamibi Imaging for Primary Hyperparathyroidism. 61
32289578 2020
9
Similar 5-year outcomes between female and male patients undergoing elective endovascular abdominal aortic aneurysm repair with the Ovation stent graft. 61
31843301 2020
10
Endovascular Aortic Aneurysm Repair without Type 2 Endoleak Using Concomitant N-Butyl-2-Cyanoacrylate Injection into the Abdominal Aortic Aneurysm Sac. 61
31863949 2020
11
Mobilization of the lumbar spine in a 76-year-old male with mechanical low back pain and an abdominal aortic aneurysm: A case report. 61
30198815 2020
12
Outcomes after treatment of complex aortic abdominal aneurysms with the fenestrated Anaconda endograft. 61
31831315 2020
13
Aneurysm Sac Thrombus Volume Predicts Aneurysm Expansion with Type II Endoleak After Endovascular Aneurysm Repair. 61
31863957 2020
14
Importance of Distal Sealing during Endovascular Aneurysm Repair Using Aneurysmal Common Iliac Artery as Landing Zone. 61
31953142 2020
15
Assessment of Neurone-Specific Enolase, Glial Fibrillary Acidic Protein and S100 B as Spinal Cord Ischemia Biomarkers in Patients Undergoing Open and Endovascular Complex Aortic Surgery: A Single-Center Experience. 61
31923599 2020
16
Elevated neutrophil-lymphocyte ratio predicts mortality following elective endovascular aneurysm repair. 61
32037083 2020
17
Endovascular Management of a Short-neck Thoracic Aortic Aneurysm With Patent Ductus Arteriosus. 61
32304690 2020
18
PKM2 Activator TEPP-46 Attenuates Thoracic Aortic Aneurysm and Dissection by Inhibiting NLRP3 Inflammasome-Mediated IL-1β Secretion. 61
32323562 2020
19
Impact of acute kidney injury on long-term outcomes after fenestrated and branched endovascular aortic aneurysm repair. 61
31843300 2020
20
Occlusion of the Celiac Artery during Endovascular Thoracoabdominal Aortic Aneurysm Repair Is associated with Increased Perioperative Morbidity and Mortality. 61
32035263 2020
21
Mid-Term Outcomes of Retroperitoneal and Transperitoneal Exposures in Open Aortic Aneurysm Repair. 61
31678129 2020
22
Artificial intelligence in abdominal aortic aneurysm. 61
32093909 2020
23
Venous leg ulcers associated with abdominal aortic aneurysm. 61
32141066 2020
24
Endovascular treatment of abdominal aortic aneurysm: a NICE U-turn. 61
32314354 2020
25
Lumbar Spine MRI: Missed Opportunities for Abdominal Aortic Aneurysm Detection. 61
31151692 2020
26
Collagen fibril abnormalities in human and mice abdominal aortic aneurysm. 61
32339711 2020
27
Aortoduodenal Fistula After Endovascular Abdominal Aortic Aneurysm Repair. 61
32295492 2020
28
Computed Tomography Identifies Clinically Unsuspected Acute Necrotizing Pancreatitis Complicating Abdominal Aortic Repair. 61
31917227 2020
29
Comment on: Endovascular treatment of abdominal aortic aneurysm: a NICE U-turn. 61
32368804 2020
30
Comment on: Endovascular treatment of abdominal aortic aneurysm: a NICE U-turn. 61
32410243 2020
31
The Impact of Epidural Analgesia on Perioperative Morbidity or Mortality after Open Abdominal Aortic Aneurysm Repair. 61
31672606 2020
32
Nationwide Analysis of Intact Abdominal Aortic Aneurysm Repair in Portugal from 2000 to 2015. 61
31917222 2020
33
HIV-Associated Aortitis Causing Rapid Development of an Abdominal Aortic Aneurysm. 61
32018021 2020
34
CircCBFB-mediated miR-28-5p facilitates abdominal aortic aneurysm via LYPD3 and GRIA4. 61
32151690 2020
35
In Vivo Aortic Magnetic Resonance Elastography in Abdominal Aortic Aneurysm: A Validation in an Animal Model. 61
32520516 2020
36
An addition to the systematic review of simulation in open abdominal aortic aneurysm repair. 61
32553408 2020
37
Cross-clamp location affects short-term survival in patients undergoing open abdominal aortic aneurysm repair. 61
31831312 2020
38
Frailty in patients with abdominal aortic aneurysm predicts prognosis after elective endovascular aneurysm repair. 61
31882319 2020
39
Juxtarenal Abdominal Aortic Aneurysm: Results of Open Surgery in an Academic Center. 61
31634598 2020
40
Outcome After Fenestrated and Branched Repair of Aortic Aneurysms-Device Failures Predict Reintervention Rates. 61
31669479 2020
41
Assessment of the Risk Analysis Index for Prediction of Mortality, Major Complications, and Length of Stay in Patients who Underwent Vascular Surgery. 61
31935435 2020
42
Translating coding lists in administrative claims-based research for cardiovascular procedures. 61
32081477 2020
43
The Spatial Morphology of Intraluminal Thrombus Influences Type II Endoleak after Endovascular Repair of Abdominal Aortic Aneurysms. 61
31394212 2020
44
Reduced Nhe1 (Na+-H+ Exchanger-1) Function Protects ApoE-Deficient Mice From Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysms. 61
32475310 2020
45
Feasibility of shear wave sonoelastography to detect endoleak and evaluate thrombus organization after endovascular repair of abdominal aortic aneurysm. 61
32130495 2020
46
Decreased Abdominal Aortic Aneurysm Size Following EVAR in Patients With CT Evidence of Subclinical Thoracic Aortic Dissection. 61
31706995 2020
47
Endovascular Treatment of a Ruptured Pararenal Abdominal Aortic Aneurysm in a Patient With Coronavirus Disease-2019: Suggestions and Case Report. 61
32422288 2020
48
Ruptured Abdominal Aortic Aneurysm Treated with Endovascular Repair in a Patient with Active COVID-19 Infection during the Pandemic. 61
32437918 2020
49
Enlargement Rate of the Ascending Aorta After Thoracic Endovascular Aortic Repair. 61
31546005 2020
50
Identification of clinically relevant variants by whole exome sequencing in Chinese patients with sporadic non-syndromic type A aortic dissection. 61
32209317 2020

Variations for Aortic Aneurysm

ClinVar genetic disease variations for Aortic Aneurysm:

6 ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 FBN1 NM_000138.5(FBN1):c.7754T>C (p.Ile2585Thr)SNV Pathogenic/Likely pathogenic 163462 rs727503054 15:48712949-48712949 15:48420752-48420752
2 TGFB2 NM_001135599.3(TGFB2):c.440C>T (p.Pro147Leu)SNV Conflicting interpretations of pathogenicity 213840 rs149533093 1:218578520-218578520 1:218405178-218405178
3 COL3A1 NM_000090.3(COL3A1):c.505C>T (p.Leu169Phe)SNV Conflicting interpretations of pathogenicity 161216 rs111391222 2:189851842-189851842 2:188987116-188987116
4 MYH11 NM_002474.3(MYH11):c.4942C>T (p.Arg1648Cys)SNV Uncertain significance 161318 rs369409348 16:15814019-15814019 16:15720162-15720162

Expression for Aortic Aneurysm

Search GEO for disease gene expression data for Aortic Aneurysm.

Pathways for Aortic Aneurysm

Pathways related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
2
Show member pathways
13.28 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
3
Show member pathways
13.24 TGFBR2 TGFBR1 TGFB3 TGFB2 MYLK MYH11
4
Show member pathways
13.03 TGFBR1 TGFB3 TGFB2 FBN2 FBN1 ELN
5
Show member pathways
12.95 TGFBR2 TGFBR1 TGFB3 TGFB2 PRKG1 MYH11
6
Show member pathways
12.88 TGFBR2 TGFBR1 TGFB3 TGFB2 MYLK ACTA2
7 12.86 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
8
Show member pathways
12.84 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
9
Show member pathways
12.79 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
10
Show member pathways
12.62 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
11
Show member pathways
12.5 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
12
Show member pathways
12.46 PRKG1 MYLK MYH11 ACTA2
13
Show member pathways
12.46 TGFB3 TGFB2 MFAP5 LOX FBN2 FBN1
14 12.37 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
15 12.27 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
16
Show member pathways
12.22 TGFBR2 TGFBR1 TGFB2 SMAD3
17 12.21 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
18 12.19 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
19 12.17 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
20 12.11 TGFBR1 SMAD3 MYLK ACTA2
21
Show member pathways
12.1 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
22 11.93 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
23 11.91 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 COL3A1
24 11.89 TGFB3 TGFB2 COL3A1
25 11.89 TGFBR1 TGFB3 TGFB2 NOTCH1
26
Show member pathways
11.89 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
27 11.85 TGFB3 TGFB2 ACTA2
28 11.85 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 FBN1
29
Show member pathways
11.84 TGFBR2 TGFBR1 SMAD3
30
Show member pathways
11.81 TGFBR2 TGFBR1 SMAD3 LOX
31 11.72 TGFBR2 TGFBR1 SMAD3
32 11.71 TGFBR2 TGFBR1 SMAD3
33
Show member pathways
11.7 TGFBR2 TGFBR1 SMAD3
34 11.7 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 ACTA2
35
Show member pathways
11.65 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
36 11.62 TGFBR2 TGFBR1 SMAD3
37 11.58 TGFBR2 TGFBR1 TGFB3 SMAD3
38 11.54 TGFBR2 TGFBR1 TGFB2
39 11.39 MYLK MYH11 ACTA2
40
Show member pathways
11.26 TGFBR2 TGFBR1 TGFB3
41 11.24 TGFBR2 TGFBR1 TGFB3
42 11.13 TGFBR2 TGFBR1 SMAD3
43 11.13 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
44
Show member pathways
11.09 TGFB3 TGFB2 MFAP5 LOX FBN2 FBN1
45 11.03 TGFB3 TGFB2 MYLK FBN2 FBN1 ELN
46 10.99 TGFBR2 TGFBR1 TGFB3 TGFB2
47 10.77 TGFB3 TGFB2
48 10.75 TGFBR2 TGFBR1 SMAD3 FBN2 FBN1

GO Terms for Aortic Aneurysm

Cellular components related to Aortic Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.96 TGFB3 TGFB2 NOTCH1 MFAP5 LOX FBN2
2 receptor complex GO:0043235 9.62 TGFBR2 TGFBR1 SMAD3 NOTCH1
3 extracellular matrix GO:0031012 9.43 MFAP5 LOX FBN2 FBN1 ELN COL3A1
4 microfibril GO:0001527 9.33 MFAP5 FBN2 FBN1
5 collagen-containing extracellular matrix GO:0062023 9.23 TGFB3 TGFB2 MFAP5 FBN2 FBN1 ELN

Biological processes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 10.12 TGFBR2 TGFBR1 TGFB3 TGFB2 NOTCH1
2 negative regulation of cell proliferation GO:0008285 10.1 TGFBR2 TGFB3 TGFB2 SMAD3 NOTCH1
3 positive regulation of gene expression GO:0010628 10.09 TGFBR1 SMAD3 SLC2A10 NOTCH1 CDKN2B-AS1 ACTA2
4 negative regulation of gene expression GO:0010629 10.03 TGFB2 SLC2A10 NOTCH1 CDKN2B-AS1
5 regulation of cell proliferation GO:0042127 10 TGFBR2 TGFB3 TGFB2 NOTCH1
6 positive regulation of cell migration GO:0030335 10 TGFBR1 SMAD3 NOTCH1 MYLK CDKN2B-AS1
7 in utero embryonic development GO:0001701 9.98 TGFBR2 TGFBR1 TGFB3 SMAD3 NOTCH1
8 response to hypoxia GO:0001666 9.97 TGFBR2 TGFB3 TGFB2 SMAD3
9 cell cycle arrest GO:0007050 9.93 TGFBR1 TGFB2 SMAD3 NOTCH1
10 muscle contraction GO:0006936 9.91 MYLK MYH11 ACTA2
11 skeletal system development GO:0001501 9.91 TGFBR1 TGFB2 SMAD3 FBN1 COL3A1
12 extracellular matrix organization GO:0030198 9.91 MFAP5 LOX FBN2 FBN1 ELN COL3A1
13 lung development GO:0030324 9.9 TGFBR2 NOTCH1 LOX
14 heart looping GO:0001947 9.87 TGFBR2 SMAD3 NOTCH1
15 blood vessel development GO:0001568 9.87 TGFBR2 LOX COL3A1
16 cellular response to transforming growth factor beta stimulus GO:0071560 9.87 TGFBR1 SMAD3 FBN1
17 SMAD protein signal transduction GO:0060395 9.86 TGFB3 TGFB2 SMAD3
18 embryonic limb morphogenesis GO:0030326 9.86 TGFB2 NOTCH1 FBN2
19 outflow tract morphogenesis GO:0003151 9.85 TGFBR2 NOTCH1 ELN
20 positive regulation of stress fiber assembly GO:0051496 9.85 TGFBR1 TGFB3 SMAD3
21 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.84 TGFBR1 TGFB3 TGFB2
22 epithelial to mesenchymal transition GO:0001837 9.83 TGFBR1 TGFB2 NOTCH1
23 positive regulation of bone mineralization GO:0030501 9.81 TGFB3 SMAD3 FBN2
24 embryonic cranial skeleton morphogenesis GO:0048701 9.8 TGFBR2 TGFBR1 SMAD3
25 heart development GO:0007507 9.8 TGFBR2 TGFBR1 TGFB2 NOTCH1 LOX FBN1
26 digestive tract development GO:0048565 9.79 TGFBR2 TGFB3 COL3A1
27 cell-cell junction organization GO:0045216 9.77 TGFB3 TGFB2 SMAD3
28 collagen fibril organization GO:0030199 9.76 TGFBR1 TGFB2 LOX COL3A1
29 activin receptor signaling pathway GO:0032924 9.75 TGFBR2 TGFBR1 SMAD3
30 ventricular trabecula myocardium morphogenesis GO:0003222 9.74 TGFBR1 TGFB2 NOTCH1
31 regulation of epithelial cell proliferation GO:0050678 9.73 SMAD3 NOTCH1
32 positive regulation of SMAD protein signal transduction GO:0060391 9.73 TGFBR1 TGFB3
33 secondary palate development GO:0062009 9.73 TGFBR2 TGFB3 TGFB2
34 pulmonary valve morphogenesis GO:0003184 9.72 TGFB2 NOTCH1
35 cardiac muscle cell proliferation GO:0060038 9.72 TGFB2 NOTCH1
36 supramolecular fiber organization GO:0097435 9.72 MFAP5 COL3A1
37 pathway-restricted SMAD protein phosphorylation GO:0060389 9.72 TGFBR2 TGFBR1 TGFB2
38 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.72 TGFBR2 TGFBR1 TGFB3 SMAD3 SLC2A10
39 response to cholesterol GO:0070723 9.71 TGFBR2 TGFBR1
40 somatic stem cell division GO:0048103 9.71 TGFB2 NOTCH1
41 salivary gland morphogenesis GO:0007435 9.71 TGFB3 TGFB2
42 cardiac left ventricle morphogenesis GO:0003214 9.71 TGFBR2 NOTCH1
43 membranous septum morphogenesis GO:0003149 9.71 TGFBR2 TGFB2
44 cardiac epithelial to mesenchymal transition GO:0060317 9.71 TGFBR1 TGFB2 NOTCH1
45 ventricular septum morphogenesis GO:0060412 9.71 TGFBR2 TGFBR1 TGFB2 NOTCH1
46 coronary artery morphogenesis GO:0060982 9.7 TGFBR1 NOTCH1
47 atrioventricular valve morphogenesis GO:0003181 9.7 TGFBR2 TGFB2 NOTCH1
48 regulation of striated muscle tissue development GO:0016202 9.68 SMAD3 LOX
49 aorta smooth muscle tissue morphogenesis GO:0060414 9.67 MYLK COL3A1
50 negative regulation of macrophage cytokine production GO:0010936 9.67 TGFB3 TGFB2

Molecular functions related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 SMAD binding GO:0046332 9.56 TGFBR2 TGFBR1 SMAD3 COL3A1
2 transforming growth factor beta binding GO:0050431 9.54 TGFBR2 TGFBR1 TGFB3
3 transforming growth factor beta receptor binding GO:0005160 9.5 TGFB3 TGFB2 SMAD3
4 activin binding GO:0048185 9.49 TGFBR2 TGFBR1
5 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.48 TGFBR2 TGFBR1
6 type I transforming growth factor beta receptor binding GO:0034713 9.46 TGFBR2 TGFB3
7 transforming growth factor beta-activated receptor activity GO:0005024 9.43 TGFBR2 TGFBR1
8 type III transforming growth factor beta receptor binding GO:0034714 9.4 TGFB3 TGFB2
9 extracellular matrix constituent conferring elasticity GO:0030023 9.33 FBN2 FBN1 ELN
10 type II transforming growth factor beta receptor binding GO:0005114 9.13 TGFBR1 TGFB3 TGFB2
11 extracellular matrix structural constituent GO:0005201 9.1 MFAP5 FBN2 FBN1 ELN EFEMP2 COL3A1

Sources for Aortic Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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