MCID: ART004
MIFTS: 46

Aortic Atherosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Aortic Atherosclerosis

MalaCards integrated aliases for Aortic Atherosclerosis:

Name: Aortic Atherosclerosis 12 15
Atherosclerosis of Aorta 12 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:10230
ICD9CM 34 440.0
SNOMED-CT 67 81817003
ICD10 32 I70.0
UMLS 70 C0155733

Summaries for Aortic Atherosclerosis

MalaCards based summary : Aortic Atherosclerosis, also known as atherosclerosis of aorta, is related to hypercholesterolemia, familial, 1 and arteries, anomalies of. An important gene associated with Aortic Atherosclerosis is APOE (Apolipoprotein E), and among its related pathways/superpathways are Metabolism and Selenium Micronutrient Network. The drugs Methylprednisolone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include Heart, kidney and liver, and related phenotypes are Decreased free cholesterol and cardiovascular system

Related Diseases for Aortic Atherosclerosis

Diseases related to Aortic Atherosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 268)
# Related Disease Score Top Affiliating Genes
1 hypercholesterolemia, familial, 1 30.6 LPL LPA CETP APOE ACE ABCG8
2 arteries, anomalies of 30.5 MIR19B1 APOE ADIPOQ ACE
3 peripheral vascular disease 30.4 PLTP LPA CETP ACE
4 hypertriglyceridemia, familial 30.2 LPL CETP APOE
5 chlamydia pneumonia 30.2 TLR4 IL10 APOE
6 cholelithiasis 30.2 APOE ABCG8 ABCG5
7 peripheral artery disease 30.1 LPA APOE ACE
8 homozygous familial hypercholesterolemia 30.1 APOE ABCG8 ABCG5 ABCA1
9 coronary stenosis 30.1 TLR4 PON1 LPL CETP APOE ACE
10 aortic valve disease 2 30.0 SPP1 LPA ACE
11 atherosclerosis susceptibility 29.9 TLR4 PON1 PLTP PLA2G7 MPO LPL
12 carotid stenosis 29.9 SPP1 MPO IL10 APOE ADIPOQ ACE
13 uremia 29.9 SPP1 PON1 LPL ACE
14 chlamydia 29.8 TLR4 IL10 IFNG
15 kidney disease 29.7 SPP1 PON1 LPA CETP APOE ADIPOQ
16 coronary heart disease 1 29.7 PON1 LPL LPA CETP APOE ADIPOQ
17 carotid artery disease 29.7 PON1 LRP1 LPA APOE ACE
18 stroke, ischemic 29.6 TLR4 PON1 PLA2G7 LPA APOE ACE
19 non-alcoholic fatty liver disease 29.6 TLR4 SPP1 LPL IL10 APOE ADIPOQ
20 familial hyperlipidemia 29.6 PON1 LPL LPA CETP APOE ADIPOQ
21 non-alcoholic steatohepatitis 29.5 TLR4 APOE ADIPOQ
22 aortic aneurysm, familial abdominal, 1 29.4 SPP1 LRP1 IL10 CETP APOE ACE
23 cerebrovascular disease 29.4 TLR4 SPP1 PON1 LPL LPA APOE
24 tangier disease 29.4 PLTP LPL LPA CETP APOE ABCG8
25 systemic lupus erythematosus 29.1 TLR4 SPP1 PON1 MPO IL10 IFNG
26 arteriosclerosis 29.1 TLR4 SPP1 PON1 LPA IL10 IFNG
27 lipid metabolism disorder 28.8 PON1 PLTP PLA2G7 LPL LPA CETP
28 chronic kidney disease 28.6 TLR4 SPP1 PON1 PLA2G7 MPO LPL
29 lipoprotein quantitative trait locus 28.6 PON1 PLTP PLA2G7 MPO LPL LPA
30 familial hypercholesterolemia 28.3 PON1 PLA2G7 MPO LRP1 LPL LPA
31 vascular disease 28.0 TLR4 SPP1 PON1 PLA2G7 MPO LPL
32 heart disease 27.8 TLR4 PON1 MSTN MPO LPL LPA
33 hypertension, essential 27.6 TLR4 SPP1 PON1 PLA2G7 MPO LPL
34 diabetes mellitus 27.1 TLR4 SPP1 PON1 PLTP PLA2G7 MSTN
35 type 2 diabetes mellitus 26.2 TLR4 SPP1 PON1 PLTP PLA2G7 MSTN
36 moderate and severe traumatic brain injury 10.4 APOE ACE
37 familial apolipoprotein c-ii deficiency 10.4 LPL CETP APOE
38 gallbladder disease 4 10.4 ABCG8 ABCG5
39 platelet glycoprotein iv deficiency 10.4 TLR4 LPL APOE
40 ostertagiasis 10.3 TLR4 IL10
41 urinary tract infection 10.3 TLR4 ACE
42 sitosterolemia 2 10.3 ABCG8 ABCG5
43 abetalipoproteinemia 10.3 LPL CETP APOE
44 hepatic lipase deficiency 10.3 LPL APOE
45 arcus corneae 10.3 LPA ABCG8 ABCG5
46 multiple cranial nerve palsy 10.3 MPO ACE
47 metal allergy 10.3 TLR4 IL10
48 apnea, obstructive sleep 10.3 APOE ADIPOQ ACE
49 sitosterolemia 10.3 ABCG8 ABCG5 ABCA1
50 iridocyclitis 10.3 TLR4 IL10 ACE

Comorbidity relations with Aortic Atherosclerosis via Phenotypic Disease Network (PDN): (show all 14)


Acute Cystitis Aortic Valve Disease 1
Deficiency Anemia Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Mitral Valve Disease
Osteoporosis Peripheral Vascular Disease
Renal Artery Atheroma Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Aortic Atherosclerosis:



Diseases related to Aortic Atherosclerosis

Symptoms & Phenotypes for Aortic Atherosclerosis

GenomeRNAi Phenotypes related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.62 ABCA1 ABCG8

MGI Mouse Phenotypes related to Aortic Atherosclerosis:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.41 ABCA1 ABCG5 ABCG8 ACE ADIPOQ APOE
2 cellular MP:0005384 10.37 ABCA1 ABCG5 ABCG8 ADIPOQ APOE IFNG
3 behavior/neurological MP:0005386 10.36 ABCA1 ABCG5 ABCG8 ACE ADIPOQ APOE
4 homeostasis/metabolism MP:0005376 10.36 ABCA1 ABCG5 ABCG8 ACE ADIPOQ APOE
5 growth/size/body region MP:0005378 10.31 ABCA1 ABCG5 ABCG8 ACE ADIPOQ APOE
6 immune system MP:0005387 10.28 ABCA1 ABCG5 ABCG8 ACE ADIPOQ APOE
7 hematopoietic system MP:0005397 10.26 ABCA1 ABCG5 ABCG8 ACE ADIPOQ APOE
8 liver/biliary system MP:0005370 10.22 ABCA1 ABCG5 ABCG8 ACE ADIPOQ APOE
9 mortality/aging MP:0010768 10.21 ABCA1 ABCG5 ACE ADIPOQ APOE IFNG
10 digestive/alimentary MP:0005381 10.11 ABCA1 ABCG5 ABCG8 APOE IFNG IL10
11 muscle MP:0005369 10.1 ABCA1 ABCG5 ADIPOQ APOE IFNG IL10
12 reproductive system MP:0005389 9.9 ABCA1 ABCG5 ABCG8 ACE APOE IFNG
13 renal/urinary system MP:0005367 9.86 ABCA1 ACE ADIPOQ APOE IFNG MSTN
14 respiratory system MP:0005388 9.56 ABCA1 ADIPOQ APOE IFNG IL10 LPL
15 vision/eye MP:0005391 9.28 ABCA1 ABCG8 ACE APOE IFNG IL10

Drugs & Therapeutics for Aortic Atherosclerosis

Drugs for Aortic Atherosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
2
Methylprednisolone hemisuccinate Approved Phase 1, Phase 2 2921-57-5
3
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
4
Prednisolone acetate Approved, Vet_approved Phase 1, Phase 2 52-21-1
5
Prednisolone phosphate Approved, Vet_approved Phase 1, Phase 2 302-25-0
6
Prednisolone hemisuccinate Experimental Phase 1, Phase 2 2920-86-7
7 Hormones Phase 1, Phase 2
8 Methylprednisolone Acetate Phase 1, Phase 2
9 Hormone Antagonists Phase 1, Phase 2
10 Antineoplastic Agents, Hormonal Phase 1, Phase 2
11 glucocorticoids Phase 1, Phase 2
12 Anti-Inflammatory Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase I/II, Single-Center, Randomized, Placebo-Controlled Study Evaluating the Therapeutic Efficacy of Intravenously Injected PEG-liposomal Prednisolone Sodium Phosphate (Nanocort®) in Subjects With Severe Inflamed Carotid or Aortic Atherosclerosis Plaques Unknown status NCT01601106 Phase 1, Phase 2 liposomal prednisolone;Placebo
2 Effects of Lomitapide on Carotid and Aortic Atherosclerosis in Patients Treated With Lomitapide in Usual Care (CAPTURE) Withdrawn NCT02399852 Lomitapide

Search NIH Clinical Center for Aortic Atherosclerosis

Genetic Tests for Aortic Atherosclerosis

Anatomical Context for Aortic Atherosclerosis

MalaCards organs/tissues related to Aortic Atherosclerosis:

40
Heart, Kidney, Liver, Endothelial, Smooth Muscle, Bone, Skin
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Aortic Atherosclerosis:
# Tissue Anatomical CompartmentCell Relevance
1 Heart Aortic Arch Arteries Vascular Smooth Muscle Cells Affected by disease

Publications for Aortic Atherosclerosis

Articles related to Aortic Atherosclerosis:

(show top 50) (show all 1161)
# Title Authors PMID Year
1
Therapeutic assessment of combination therapy with a neprilysin inhibitor and angiotensin type 1 receptor antagonist on angiotensin II-induced atherosclerosis, abdominal aortic aneurysms, and hypertension. 61
33707301 2021
2
An unexpected paradox: wall shear stress in the aorta is less in patients with severe atherosclerosis regardless of obesity. 61
33242600 2021
3
Sitagliptin, a dipeptidyl peptidase-4 inhibitor, attenuates apoptosis of vascular smooth muscle cells and reduces atherosclerosis in diabetic apolipoprotein E-deficient mice. 61
33781961 2021
4
Effects from the induction of heat shock proteins in a murine model due to progression of aortic atherosclerosis. 61
33782520 2021
5
Screening of the Abdominal Aorta During Routine Echocardiographic Examination Is Cost-effective and Leads to Increase in Statin Utilization by Detecting Subclinical Atherosclerosis. 61
32769485 2021
6
Numerical analysis of the hemodynamics of rat aorta based on magnetic resonance imaging and fluid-structure interaction. 61
33750033 2021
7
Mir-1, miR-122, miR-132, and miR-133 Are Related to Subclinical Aortic Atherosclerosis Associated with Metabolic Syndrome. 61
33557426 2021
8
Primary Aorto-Duodenal Fistula in Association with Chronic Ischemic Enteritis: A Case Report. 61
33549790 2021
9
An unusual presentation of dyspnea following septal ablation for obstructive hypertrophic cardiomyopathy. 61
33345409 2021
10
Human apolipoprotein A-II reduces atherosclerosis in knock-in rabbits. 61
33296791 2021
11
Influence of Pulse Wave Velocity on Atherosclerosis and Blood Flow Reversal in the Aorta: A 4-Dimensional Flow Magnetic Resonance Imaging Study in Acute Stroke Patients and Matched Controls. 61
33492047 2021
12
Neurologic complications of diseases of the aorta. 61
33632441 2021
13
Regional Variation in Genetic Control of Atherosclerosis in Hyperlipidemic Mice. 61
33109727 2020
14
Nicotinamide Prevents Apolipoprotein B-Containing Lipoprotein Oxidation, Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice. 61
33233455 2020
15
Correction to: Aortic adventitial thickness as a marker of aortic atherosclerosis, vascular stiffness, and vessel remodeling in systemic lupus erythematosus. 61
33159282 2020
16
Germ-free housing conditions do not affect aortic root and aortic arch lesion size of late atherosclerotic low-density lipoprotein receptor-deficient mice. 61
32579470 2020
17
High Wall Shear Stress Is Related to Atherosclerotic Plaque Rupture in the Aortic Arch of Patients with Cardiovascular Disease: A Study with Computational Fluid Dynamics Model and Non-Obstructive General Angioscopy. 61
33012739 2020
18
The Asian system for cardiac operative risk evaluation for predicting mortality after isolated coronary artery bypass graft surgery (ASCORE-C). 61
32652707 2020
19
Impact of shaggy aorta on outcomes of open thoracoabdominal aortic aneurysm repair. 61
31587889 2020
20
Aortic adventitial thickness as a marker of aortic atherosclerosis, vascular stiffness, and vessel remodeling in systemic lupus erythematosus. 61
33025269 2020
21
Quercetin Inhibited Endothelial Dysfunction and Atherosclerosis in Apolipoprotein E-Deficient Mice: Critical Roles for NADPH Oxidase and Heme Oxygenase-1. 61
32880455 2020
22
Protective Role of C3aR (C3a Anaphylatoxin Receptor) Against Atherosclerosis in Atherosclerosis-Prone Mice. 61
32762445 2020
23
Therapeutic effects of chitin from Pleurotus eryngii on high-fat diet induced obesity in rats. 61
32978911 2020
24
Spontaneous ruptured aortic plaque and injuries: insights for aging and acute aortic syndrome from non-obstructive general angioscopy. 61
31882197 2020
25
Inhibition of JAK2 Suppresses Myelopoiesis and Atherosclerosis in Apoe-/- Mice. 61
32086626 2020
26
Targeted invalidation of SR-B1 in macrophages reduces macrophage apoptosis and accelerates atherosclerosis. 61
31119270 2020
27
Impact of Aortic Atherosclerosis Burden on Outcomes of Surgical Aortic Valve Replacement. 61
31400333 2020
28
Aortic atherosclerosis complicated by retroperitoneal fibrosis treated only by optimal cardiovascular risk factors management. 61
32057325 2020
29
Estrogen-SIRT1 Axis Plays a Pivotal Role in Protecting Arteries Against Menopause-Induced Senescence and Atherosclerosis. 61
31105126 2020
30
Macrophages in Atherosclerosis Regression. 61
31722535 2020
31
Chronic Staphylococcus aureus Superantigen Toxic Shock Syndrome Toxin-1 Exposure Accelerates the Progression of Atherosclerosis in Rabbits. 61
31903005 2020
32
Is it possible to predict atherosclerosis in the ascending aorta by the patient's lipid panel? 61
33305062 2020
33
The Relationship between the Mean Platelet Volume and Carotid Atherosclerosis and Prognosis in Patients with Acute Cerebral Infarction. 61
33490251 2020
34
Efficacy of Curcumin on Aortic Atherosclerosis: A Systematic Review and Meta-Analysis in Mouse Studies and Insights into Possible Mechanisms. 61
31998433 2020
35
Involvement of Low-Density Lipoprotein Receptor in the Pathogenesis of Pulmonary Hypertension. 61
31914876 2020
36
Myricitrin exhibits anti-atherosclerotic and anti-hyperlipidemic effects in diet-induced hypercholesterolemic rats. 61
31865448 2019
37
In vivo alpha-V beta-3 integrin expression in human aortic atherosclerosis. 61
31422361 2019
38
[Metformin inhibits aortic atherosclerosis in mice by regulating actin skeleton in vascular smooth muscle cells]. 61
31852643 2019
39
Aortic Plaque Distribution, and Association between Aortic Plaque and Atherosclerotic Risk Factors: An Aortic Angioscopy Study. 61
30918164 2019
40
Stimulation of Collateral Vessel Growth by Inhibition of Galectin 2 in Mice Using a Single-Domain Llama-Derived Antibody. 61
31594443 2019
41
Retrograde aortic blood flow as a mechanism of stroke: MR evaluation of the prevalence in a population-based study. 61
30877458 2019
42
The Effects of Dimethyl Fumarate on Atherosclerosis in the Apolipoprotein E-Deficient Mouse Model with Streptozotocin-Induced Hyperglycemia Mediated By the Nuclear Factor Erythroid 2-Related Factor 2/Antioxidant Response Element (Nrf2/ARE) Signaling Pathway. 61
31645538 2019
43
Rivaroxaban Suppresses the Progression of Ischemic Cardiomyopathy in a Murine Model of Diet-Induced Myocardial Infarction. 61
30867376 2019
44
The importance of physiologic ischemia training in preventing the development of atherosclerosis: the role of endothelial progenitor cells in atherosclerotic rabbits. 61
30724819 2019
45
Neurologic Deficit After Aortic Arch Replacement: The Influence of the Aortic Atherosclerosis. 61
30710519 2019
46
Tailoring the Approach to Embolic Stroke of Undetermined Source: A Review. 61
30958521 2019
47
Effects of a Proximal Seal System on Neurologic Outcomes of Off-Pump Coronary Artery Bypass Grafting. 61
31019167 2019
48
Sortilin promotes macrophage cholesterol accumulation and aortic atherosclerosis through lysosomal degradation of ATP-binding cassette transporter A1 protein. 61
30950489 2019
49
DNA methylation and hydroxymethylation are associated with the degree of coronary atherosclerosis in elderly patients with coronary heart disease. 61
30867120 2019
50
Helper-dependent adenovirus-mediated gene transfer of a secreted LDL receptor/transferrin chimeric protein reduces aortic atherosclerosis in LDL receptor-deficient mice. 61
30700805 2019

Variations for Aortic Atherosclerosis

Expression for Aortic Atherosclerosis

Search GEO for disease gene expression data for Aortic Atherosclerosis.

Pathways for Aortic Atherosclerosis

Pathways related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 PON1 PLTP PLA2G7 LRP1 LPL LPA
2
Show member pathways
12.11 MPO IFNG APOE ABCA1
3
Show member pathways
12.09 PLTP LPL LPA CETP APOE ABCG8
4 11.68 SPP1 LPL ADIPOQ
5
Show member pathways
11.57 TLR4 IL10 IFNG
6 11.55 PLTP LPL ADIPOQ
7
Show member pathways
11.35 PLTP LRP1 LPL LPA CETP APOE
8 11.29 MPO LRP1 LPA
9 11.26 TLR4 LRP1 IL10 IFNG
10
Show member pathways
11.24 ABCG8 ABCG5 ABCA1
11 11.2 SPP1 IFNG APOE
12 11.14 LPL ABCG8 ABCG5
13 10.96 TLR4 LRP1 APOE ACE

GO Terms for Aortic Atherosclerosis

Cellular components related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10 SPP1 PON1 PLTP PLA2G7 MSTN MPO
2 receptor complex GO:0043235 9.62 TLR4 LRP1 ABCG8 ABCG5
3 extracellular space GO:0005615 9.47 SPP1 PON1 PLTP PLA2G7 MSTN MPO
4 chylomicron GO:0042627 9.37 LPL APOE
5 high-density lipoprotein particle GO:0034364 9.35 PON1 PLTP PLA2G7 CETP APOE
6 ATP-binding cassette (ABC) transporter complex GO:0043190 9.26 ABCG8 ABCG5

Biological processes related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 10.06 PON1 PLTP PLA2G7 LRP1 LPL LPA
2 response to drug GO:0042493 10 LPL IL10 ADIPOQ ABCG8 ABCG5 ABCA1
3 cholesterol metabolic process GO:0008203 9.92 PON1 CETP APOE ABCA1
4 positive regulation of inflammatory response GO:0050729 9.89 TLR4 PLA2G7 LPL IFNG
5 response to nutrient GO:0007584 9.88 ADIPOQ ABCG8 ABCG5 ABCA1
6 lipid transport GO:0006869 9.87 PLTP LPA CETP APOE ABCG8 ABCG5
7 positive regulation of interleukin-6 production GO:0032755 9.86 TLR4 LPL IFNG
8 positive regulation of tumor necrosis factor production GO:0032760 9.86 TLR4 LPL IFNG
9 negative regulation of tumor necrosis factor production GO:0032720 9.85 TLR4 IL10 ADIPOQ
10 negative regulation of interleukin-6 production GO:0032715 9.85 TLR4 MIR19B1 IL10
11 response to glucocorticoid GO:0051384 9.84 MSTN IL10 ADIPOQ
12 retinoid metabolic process GO:0001523 9.83 LRP1 LPL APOE
13 response to nutrient levels GO:0031667 9.83 PON1 ADIPOQ ABCG8 ABCG5 ABCA1
14 positive regulation of interleukin-1 beta production GO:0032731 9.82 TLR4 LPL IFNG
15 positive regulation of chemokine production GO:0032722 9.81 TLR4 LPL IFNG
16 triglyceride metabolic process GO:0006641 9.8 LPL CETP APOE
17 lipoprotein metabolic process GO:0042157 9.78 LRP1 APOE ABCA1
18 phospholipid transport GO:0015914 9.78 PLTP CETP ABCG8 ABCA1
19 response to muscle activity GO:0014850 9.77 MSTN ABCG8 ABCG5
20 triglyceride homeostasis GO:0070328 9.77 LPL CETP APOE ABCG8 ABCG5
21 sterol transport GO:0015918 9.76 PLTP ABCG8 ABCG5
22 cholesterol efflux GO:0033344 9.76 APOE ABCG8 ABCG5 ABCA1
23 reverse cholesterol transport GO:0043691 9.74 CETP APOE ABCA1
24 high-density lipoprotein particle remodeling GO:0034375 9.73 PLTP CETP APOE
25 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.72 CETP ADIPOQ ABCA1
26 positive regulation of MHC class II biosynthetic process GO:0045348 9.71 TLR4 IL10 IFNG
27 positive regulation of signaling receptor activity GO:2000273 9.7 IL10 IFNG
28 bile acid signaling pathway GO:0038183 9.69 ABCG8 ABCG5
29 high-density lipoprotein particle assembly GO:0034380 9.69 APOE ABCA1
30 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.69 TLR4 LRP1 LPL
31 phospholipid efflux GO:0033700 9.68 APOE ABCA1
32 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.68 IL10 ADIPOQ
33 intestinal cholesterol absorption GO:0030299 9.68 ABCG8 ABCG5
34 chylomicron remodeling GO:0034371 9.67 LPL APOE
35 very-low-density lipoprotein particle remodeling GO:0034372 9.67 LPL CETP APOE
36 positive regulation of amyloid-beta clearance GO:1900223 9.65 LRP1 APOE
37 regulation of Cdc42 protein signal transduction GO:0032489 9.65 APOE ABCA1
38 low-density lipoprotein particle remodeling GO:0034374 9.65 PLA2G7 MPO LPA CETP APOE
39 regulation of plasma lipoprotein particle levels GO:0097006 9.64 MIR19B1 APOE
40 lipoprotein biosynthetic process GO:0042158 9.64 APOE ABCA1
41 intermembrane lipid transfer GO:0120009 9.63 PLTP CETP APOE ABCG8 ABCG5 ABCA1
42 negative regulation of intestinal cholesterol absorption GO:0045796 9.62 ABCG8 ABCG5
43 negative regulation of intestinal phytosterol absorption GO:0010949 9.61 ABCG8 ABCG5
44 cholesterol homeostasis GO:0042632 9.5 MIR19B1 LPL CETP APOE ABCG8 ABCG5
45 positive regulation of cholesterol efflux GO:0010875 9.1 PON1 PLTP LRP1 APOE ADIPOQ ABCA1

Molecular functions related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.8 TLR4 MSTN LPL APOE ADIPOQ ABCA1
2 cytokine activity GO:0005125 9.77 SPP1 MSTN IL10 IFNG ADIPOQ
3 amyloid-beta binding GO:0001540 9.67 TLR4 LRP1 APOE
4 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.63 ABCG8 ABCG5 ABCA1
5 phosphatidylcholine binding GO:0031210 9.58 PLTP CETP ABCA1
6 heparin binding GO:0008201 9.55 MSTN MPO LPL LPA APOE
7 lipoprotein particle binding GO:0071813 9.48 LPL APOE
8 triglyceride binding GO:0017129 9.43 LPL CETP
9 heparan sulfate proteoglycan binding GO:0043395 9.43 LRP1 LPL APOE
10 apolipoprotein binding GO:0034185 9.26 LRP1 LPL LPA ABCA1
11 intermembrane cholesterol transfer activity GO:0120020 9.1 PLTP CETP APOE ABCG8 ABCG5 ABCA1

Sources for Aortic Atherosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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