MCID: ART004
MIFTS: 45

Aortic Atherosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Aortic Atherosclerosis

MalaCards integrated aliases for Aortic Atherosclerosis:

Name: Aortic Atherosclerosis 38 12 15
Atherosclerosis of Aorta 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10230
ICD10 33 I70.0
ICD9CM 35 440.0
SNOMED-CT 68 81817003
UMLS 73 C0155733

Summaries for Aortic Atherosclerosis

MalaCards based summary : Aortic Atherosclerosis, also known as atherosclerosis of aorta, is related to coronary artery anomaly and cholelithiasis. An important gene associated with Aortic Atherosclerosis is APOE (Apolipoprotein E), and among its related pathways/superpathways are Metabolism and Lipoprotein metabolism. The drugs Angiotensin II and Olmesartan have been mentioned in the context of this disorder. Affiliated tissues include Heart, heart and smooth muscle, and related phenotypes are Decreased free cholesterol and Decreased HPV16-GFP infection

Related Diseases for Aortic Atherosclerosis

Diseases related to Aortic Atherosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 coronary artery anomaly 29.8 ACE CETP LPA PON1
2 cholelithiasis 29.6 ABCG5 ABCG8 APOE
3 homozygous familial hypercholesterolemia 29.4 ABCG5 ABCG8 APOE LDLR
4 aortic valve insufficiency 29.4 ACE PON1
5 arteries, anomalies of 29.3 ABCA1 ACE APOE CETP LDLR LPA
6 kidney disease 29.2 ACE APOE LPA SPP1
7 atherosclerosis susceptibility 29.1 ABCA1 APOE CETP LDLR LPA PON1
8 chronic kidney failure 29.0 ACE LPA PON1 SPP1
9 hypercholesterolemia, familial 28.2 ABCA1 ABCG5 ABCG8 ACE APOE CETP
10 hypercholesterolemia, autosomal dominant, type b 10.2 APOE LDLR
11 defective apolipoprotein b-100 10.2 APOE LDLR
12 sea-blue histiocyte disease 10.1 APOE LDLR
13 leukodystrophy, hypomyelinating, 3 10.1 APOE LPA
14 alzheimer disease 2 10.1 APOE CETP
15 hypertriglyceridemia, familial 10.1 APOE CETP
16 hypobetalipoproteinemia, familial, 2 10.1 CETP LPA
17 moderate and severe traumatic brain injury 10.1 ACE APOE
18 generalized atherosclerosis 10.1 ACE APOE
19 cerebral atherosclerosis 10.1 ACE APOE
20 huntington disease-like 1 10.1 APOE CETP LPA
21 gallbladder disease 4 10.1 ABCG5 ABCG8
22 smith-lemli-opitz syndrome 10.1 ABCA1 APOE LDLR
23 abetalipoproteinemia 10.1 APOE CETP LDLR
24 hypoalphalipoproteinemia, primary 10.1 ABCA1 CETP LDLR
25 coronary restenosis 10.1 ACE CETP
26 hypolipoproteinemia 10.1 ABCA1 APOE LPA
27 lipoprotein glomerulopathy 10.0 APOE LDLR LPA
28 ischemic heart disease 10.0 ACE APOE
29 xanthomatosis 10.0 APOE LDLR LPA
30 niemann-pick disease, type b 10.0 ABCA1 LPA
31 macular degeneration, age-related, 1 10.0 ABCA1 APOE CETP
32 hemorrhage, intracerebral 10.0 ACE APOE
33 cholestasis, progressive familial intrahepatic, 1 10.0 ABCG5 ABCG8
34 hyperalphalipoproteinemia 1 10.0 ABCA1 APOE CETP LDLR
35 familial cold autoinflammatory syndrome 2 10.0 LDLR PON1
36 tangier disease 9.9 ABCA1 APOE CETP LPA
37 carotid artery disease 9.9 ACE APOE LPA
38 hyperlipoproteinemia, type iii 9.9 APOE CETP LDLR LPA
39 arcus corneae 9.9 APOE CETP LDLR LPA
40 lecithin:cholesterol acyltransferase deficiency 9.9 APOE CETP LDLR LPA
41 systemic lupus erythematosus 9.9
42 patent foramen ovale 9.9
43 lupus erythematosus 9.9
44 carotid stenosis 9.9 ACE APOE SPP1
45 cholestasis, benign recurrent intrahepatic, 1 9.9 ABCG5 ABCG8
46 gallbladder disease 9.9 ABCG5 ABCG8 APOE CETP
47 aortic valve disease 1 9.8 ACE LPA SPP1
48 sitosterolemia 9.8 ABCG5 ABCG8
49 vascular dementia 9.8 ACE APOE PON1
50 alzheimer disease 9.8

Comorbidity relations with Aortic Atherosclerosis via Phenotypic Disease Network (PDN): (show all 16)


Acute Cystitis Aortic Valve Disease 1
Chronic Myocardial Ischemia Deficiency Anemia
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Ischemic Heart Disease Mitral Valve Disease
Osteoporosis Peripheral Vascular Disease
Renal Artery Atheroma Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Aortic Atherosclerosis:



Diseases related to Aortic Atherosclerosis

Symptoms & Phenotypes for Aortic Atherosclerosis

GenomeRNAi Phenotypes related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.63 ABCA1 ABCG8 APOE CETP LDLR LPA
2 Decreased HPV16-GFP infection GR00350-A 9.13 ABCA1 ABCG8 LDLR
3 Increased LDL uptake GR00340-A-1 8.62 APOE LDLR

MGI Mouse Phenotypes related to Aortic Atherosclerosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 ABCA1 ABCG5 ACE APOE LDLR PON1
2 cellular MP:0005384 9.87 ABCA1 ABCG5 ABCG8 APOE LDLR PON1
3 homeostasis/metabolism MP:0005376 9.76 ABCA1 ABCG5 ABCG8 ACE APOE LDLR
4 digestive/alimentary MP:0005381 9.65 ABCA1 ABCG5 ABCG8 APOE LDLR
5 liver/biliary system MP:0005370 9.5 ABCA1 ABCG5 ABCG8 ACE APOE LDLR
6 muscle MP:0005369 9.02 ABCA1 ABCG5 APOE LDLR SPP1

Drugs & Therapeutics for Aortic Atherosclerosis

Drugs for Aortic Atherosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Angiotensin II Approved, Investigational Phase 3 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
2
Olmesartan Approved, Investigational Phase 3 144689-63-4, 144689-24-7 158781 130881
3 Angiotensin Receptor Antagonists Phase 3
4 Angiotensin II Type 1 Receptor Blockers Phase 3
5 Angiotensinogen Phase 3
6 Antihypertensive Agents Phase 3
7
Olmesartan medoxomil Phase 3 144689-63-4 130881
8
Methylprednisolone hemisuccinate Approved Phase 1, Phase 2 2921-57-5
9
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
10
Prednisolone phosphate Approved, Vet_approved Phase 1, Phase 2 302-25-0
11
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
12
Prednisolone hemisuccinate Experimental Phase 1, Phase 2 2920-86-7
13 Protective Agents Phase 1, Phase 2
14 glucocorticoids Phase 1, Phase 2
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
16 Gastrointestinal Agents Phase 1, Phase 2
17 Neuroprotective Agents Phase 1, Phase 2
18 Antineoplastic Agents, Hormonal Phase 1, Phase 2
19 Hormone Antagonists Phase 1, Phase 2
20 Antiemetics Phase 1, Phase 2
21 Methylprednisolone acetate Phase 1, Phase 2
22 Autonomic Agents Phase 1, Phase 2
23 Hormones Phase 1, Phase 2
24 Anti-Inflammatory Agents Phase 1, Phase 2
25 Peripheral Nervous System Agents Phase 1, Phase 2
26 Prednisolone acetate Phase 1, Phase 2
27
Nicotinamide Approved, Investigational Early Phase 1 98-92-0 936
28
Ethanol Approved Not Applicable 64-17-5 702
29
Glucosamine Approved, Investigational Not Applicable 3416-24-8 439213
30
Folic Acid Approved, Nutraceutical, Vet_approved Early Phase 1 59-30-3 6037
31
Niacin Approved, Investigational, Nutraceutical Early Phase 1 59-67-6 938
32 Calcium, Dietary
33 Folate Early Phase 1
34 Lipid Regulating Agents Early Phase 1,Not Applicable
35 Vitamin B9 Early Phase 1
36 Micronutrients Early Phase 1
37 Vitamin B3 Early Phase 1
38 Vasodilator Agents Early Phase 1
39 Vitamin B Complex Early Phase 1
40 Antimetabolites Early Phase 1,Not Applicable
41 Hypolipidemic Agents Early Phase 1,Not Applicable
42 Nicotinic Acids Early Phase 1
43 Trace Elements Early Phase 1
44 Vitamins Early Phase 1
45 Anti-Infective Agents Not Applicable
46 Central Nervous System Depressants Not Applicable
47 Anti-Infective Agents, Local Not Applicable
48 Hypoglycemic Agents Not Applicable
49 Fibrinolytic Agents Not Applicable
50 Glucuronyl glucosamine glycan sulfate Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Effect Study of Modified Transoesophageal Echocardiography on Cerebral Embolization After Cardiothoracic Surgery Completed NCT01310608 Phase 3
2 A Randomized, Double Blind Study To Compare The Effects Of Olmesartan Medoxomil Versus Placebo In Patients With Established Atherosclerosis Completed NCT00382213 Phase 3 Olmesartan medoxomil;Placebo
3 Silencing Inflammatory Activity by Injecting Nanocort in Patients at Risk for Atherosclerotic Disease Unknown status NCT01601106 Phase 1, Phase 2 liposomal prednisolone;Placebo
4 Risk Factors Associated With Calcification of the Aortic Valve Unknown status NCT00375336
5 Predicting Aortic Stenosis Progression by Measuring Serum Calcification Propensity Unknown status NCT02241109 Early Phase 1
6 Early Aortic Valve Lipoprotein(a) Lowering Trial Unknown status NCT02109614 Early Phase 1 Extended release Niacin;Placebo Comparator
7 Initial Patient Evaluation in the Emergency Department With Point-of-Care Ultrasonography Unknown status NCT02099045
8 Screening for Abdominal Aortic Aneurysm and Abdominal Aortic Atherosclerosis by Hand-Held Ultrasonography Completed NCT01679288 Not Applicable
9 Angiogenesis and Fibrosis in Myocardial Infarction Completed NCT01813045
10 Angiogenesis and Fibrosis in Aortic Stenosis Completed NCT01837160
11 Alcohol and Atherosclerosis Pilot Study Completed NCT00786279 Not Applicable
12 Role of Active Valvular Calcification and Inflammation in Patients With Aortic Stenosis Completed NCT01358513
13 Interest of Pulse Wave Velocity Measurement as a Predictor of Severity of Aortic Stenosis Recruiting NCT03140735 Not Applicable
14 Effects of Lomitapide on Carotid and Aortic Atherosclerosis Withdrawn NCT02399852 Lomitapide

Search NIH Clinical Center for Aortic Atherosclerosis

Genetic Tests for Aortic Atherosclerosis

Anatomical Context for Aortic Atherosclerosis

MalaCards organs/tissues related to Aortic Atherosclerosis:

41
Heart, Smooth Muscle, Kidney, Endothelial, Monocytes, Brain, Liver
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Aortic Atherosclerosis:
# Tissue Anatomical CompartmentCell Relevance
1 Heart Aortic Arch Arteries Vascular Smooth Muscle Cells Affected by disease

Publications for Aortic Atherosclerosis

Articles related to Aortic Atherosclerosis:

(show top 50) (show all 318)
# Title Authors Year
1
Isoquinoline Alkaloids and Indole Alkaloids Attenuate Aortic Atherosclerosis in Apolipoprotein E Deficient Mice: A Systematic Review and Meta-Analysis. ( 29922166 )
2018
2
Proteomic Architecture of Human Coronary and Aortic Atherosclerosis. ( 29915101 )
2018
3
Aortic atherosclerosis is a key modulator of the prognostic value of postural blood pressure changes. ( 29202333 )
2018
4
The Extent of Aortic Atherosclerosis Predicts the Occurrence, Severity, and Recovery of Acute Kidney Injury After Transcatheter Aortic Valve Replacement. ( 30354779 )
2018
5
Corrigendum to "The therapeutic effect of rosuvastatin and propylthiouracil on ameliorating high-cholesterol diet-induced rabbit aortic atherosclerosis and stiffness" [Int. J. Cardiol. 227 (2017) 938-949]. ( 30384978 )
2018
6
Myostatin mediates abdominal aortic atherosclerosis progression by inducing vascular smooth muscle cell dysfunction and monocyte recruitment. ( 28406165 )
2017
7
Aortic Atherosclerosis Determines Increased Retrograde Blood Flow as a Potential Mechanism of Retrograde Embolic Stroke. ( 28049202 )
2017
8
Flavonols reduce aortic atherosclerosis lesion area in apolipoprotein E deficient mice: A systematic review and meta-analysis. ( 28742839 )
2017
9
Are structural brain changes driven by aortic atherosclerosis? ( 28870632 )
2017
10
The therapeutic effect of rosuvastatin and propylthiouracil on ameliorating high-cholesterol diet-induced rabbit aortic atherosclerosis and stiffness. ( 27932239 )
2017
11
A Protocol for Diagnosis and Management of Aortic Atherosclerosis in Cardiac Surgery Patients. ( 28852575 )
2017
12
An Obesity Paradox: Increased Body Mass Index Is Associated with Decreased Aortic Atherosclerosis. ( 28593612 )
2017
13
Effects of Restoration of Blood Flow on the Development of Aortic Atherosclerosis in ApoE-/- Mice With Unilateral Renal Artery Stenosis. ( 27039929 )
2016
14
Histological evaluation disqualifies IMT and calcification scores as surrogates for grading coronary and aortic atherosclerosis. ( 27668706 )
2016
15
Early steatohepatitis in hyperlipidemic mice with endothelial-specific gain of TRPC3 function precedes changes in aortic atherosclerosis. ( 27449657 )
2016
16
A preliminary ex vivo study of 3D ultrasonography of aortic atherosclerosis using autopsied aorta. ( 27030503 )
2016
17
Imaging Techniques for Diagnosis of Thoracic Aortic Atherosclerosis. ( 26966580 )
2016
18
Study of the Blood Supply Fraction of the Ascending Aorta and Its Effect in Diagnosing Early Ascending Aortic Atherosclerosis. ( 26921087 )
2016
19
Establishment of Rabbit Abdominal Aortic Atherosclerosis Model by Pancreatic Elastase Infiltration Associated with High Fat Diet. ( 27122900 )
2015
20
Aortic Atherosclerosis: A Common Source of Cerebral Emboli, Often Overlooked! ( 25569596 )
2015
21
An elevated IgG4 response in chronic infectious aortitis is associated with aortic atherosclerosis. ( 26336884 )
2015
22
3D.03: INFLUENCE OF AORTIC ATHEROSCLEROSIS ON THE PROGNOSTIC VALUE OF POSTURAL BLOOD PRESSURE CHANGES. ( 26102815 )
2015
23
Blood pressure variability and aortic atherosclerosis--Cause or consequence? ( 26071655 )
2015
24
Increasing severity of aortic atherosclerosis in coronary artery bypass grafting patients evaluated by transesophageal echocardiography. ( 25379067 )
2015
25
Noninvasive imaging of aortic atherosclerosis by ultrasound biomicroscopy in a mouse model. ( 25542946 )
2015
26
Pulse wave velocity correlates with aortic atherosclerosis assessed with transesophageal echocardiography. ( 25903165 )
2015
27
Association between chronic kidney disease and thoracic aortic atherosclerosis detected using transesophageal echocardiography. ( 25299964 )
2014
28
Transoesophageal echocardiography of aortic atherosclerosis: the additive value of three-dimensional over two-dimensional imaging. ( 25300525 )
2014
29
Resveratrol supplementation reduces aortic atherosclerosis and calcification and attenuates loss of aerobic capacity in a mouse model of uremia. ( 24476222 )
2014
30
Can aortic atherosclerosis or epicardial adipose tissue volume be used as a marker for predicting coronary artery disease? ( 24954286 )
2014
31
No renal phenotype in human phospholipid transfer protein transgenic apolipoprotein E deficient mice despite severe aortic atherosclerosis. ( 25651711 )
2014
32
Paraoxonase (PON1) activity in patients with subclinical thoracic aortic atherosclerosis. ( 24700021 )
2014
33
MicroRNA-19b promotes macrophage cholesterol accumulation and aortic atherosclerosis by targeting ATP-binding cassette transporter A1. ( 25084135 )
2014
34
Aortic Atherosclerosis in Systemic Lupus Erythematosus. ( 25593786 )
2014
35
The risk association between experimental portal hypertension and an aortic atherosclerosis-like disease. ( 22730048 )
2013
36
Effect of age on aortic atherosclerosis. ( 23888172 )
2013
37
Abdominal aortic atherosclerosis at MR imaging is associated with cardiovascular events: the Dallas heart study. ( 23781118 )
2013
38
Multimodality imaging of subclinical aortic atherosclerosis: relation of aortic stiffness to calcification and plaque in female twins. ( 23339166 )
2013
39
Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the Framingham Heart Study. ( 24242683 )
2013
40
Uric acid and high sensitive C-reactive protein are associated with subclinical thoracic aortic atherosclerosis. ( 23159203 )
2013
41
Polymicrobial infection with major periodontal pathogens induced periodontal disease and aortic atherosclerosis in hyperlipidemic ApoE(null) mice. ( 23451182 )
2013
42
Associations between serum lipoprotein(a) levels and the severity of coronary and aortic atherosclerosis. ( 22387060 )
2012
43
The LDL-cholesterol to HDL-cholesterol ratio and the severity of coronary and aortic atherosclerosis. ( 22516791 )
2012
44
Analysis of pulse wave velocity in the thoracic aorta by flow-sensitive four-dimensional MRI: reproducibility and correlation with characteristics in patients with aortic atherosclerosis. ( 22271330 )
2012
45
Three-Dimensional Transesophageal Echocardiography of Aortic Atherosclerosis. ( 22957900 )
2012
46
Association between kidney dysfuction and the severity of coronary and aortic atherosclerosis. ( 22770127 )
2012
47
Aortic atherosclerosis and embolic events. ( 22437371 )
2012
48
Comparison of frequencies of patent foramen ovale and thoracic aortic atherosclerosis in patients with cryptogenic ischemic stroke undergoing transesophageal echocardiography. ( 21889761 )
2011
49
Relation between the incidence, location, and extent of thoracic aortic atherosclerosis detected by transesophageal echocardiography and the extent of coronary artery disease by angiography. ( 21129720 )
2011
50
Coronary computed tomography angiography without catheter angiography before bypass surgery in a patient with diffuse aortic atherosclerosis. ( 20871417 )
2011

Variations for Aortic Atherosclerosis

Expression for Aortic Atherosclerosis

Search GEO for disease gene expression data for Aortic Atherosclerosis.

Pathways for Aortic Atherosclerosis

Pathways related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.6 ABCA1 ABCG5 ABCG8 APOE CETP LDLR
2
Show member pathways
12.04 ABCA1 ABCG5 ABCG8 APOE CETP LDLR
3
Show member pathways
11.97 ABCA1 APOE LDLR
4 11.35 ABCG5 ABCG8 LDLR
5
Show member pathways
11.24 ABCA1 ABCG5 ABCG8 APOE CETP LDLR
6 11.16 APOE SPP1
7 11.14 ABCG5 ABCG8
8
Show member pathways
11.08 ABCA1 ABCG5 ABCG8
9 11.02 ABCA1 ABCG5
10 10.84 ACE APOE LDLR
11 10.81 ABCA1 CETP
12 10.68 ABCA1 LDLR

GO Terms for Aortic Atherosclerosis

Cellular components related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 ACE APOE CETP LPA PON1 SPP1
2 receptor complex GO:0043235 9.43 ABCG5 ABCG8 LDLR
3 clathrin-coated endocytic vesicle membrane GO:0030669 9.32 APOE LDLR
4 low-density lipoprotein particle GO:0034362 9.16 APOE LDLR
5 ATP-binding cassette (ABC) transporter complex GO:0043190 8.96 ABCG5 ABCG8
6 high-density lipoprotein particle GO:0034364 8.8 APOE CETP PON1

Biological processes related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.88 ABCA1 APOE CETP LDLR LPA PON1
2 response to drug GO:0042493 9.86 ABCA1 ABCG5 ABCG8
3 negative regulation of gene expression GO:0010629 9.86 ACE APOE LDLR
4 steroid metabolic process GO:0008202 9.8 ABCA1 APOE CETP LDLR
5 response to nutrient GO:0007584 9.77 ABCA1 ABCG5 ABCG8
6 cholesterol transport GO:0030301 9.7 ABCA1 CETP LDLR
7 lipoprotein metabolic process GO:0042157 9.69 ABCA1 APOE LDLR
8 lipid homeostasis GO:0055088 9.68 APOE CETP
9 excretion GO:0007588 9.68 ABCG5 ABCG8
10 triglyceride metabolic process GO:0006641 9.67 APOE CETP
11 long-term memory GO:0007616 9.67 APOE LDLR
12 triglyceride homeostasis GO:0070328 9.67 APOE CETP
13 drug transmembrane transport GO:0006855 9.66 ABCG5 ABCG8
14 positive regulation of endocytosis GO:0045807 9.66 APOE LDLR
15 cellular response to low-density lipoprotein particle stimulus GO:0071404 9.65 ABCA1 LDLR
16 high-density lipoprotein particle remodeling GO:0034375 9.65 APOE CETP
17 regulation of cholesterol metabolic process GO:0090181 9.65 APOE LDLR
18 reverse cholesterol transport GO:0043691 9.65 ABCA1 APOE CETP
19 high-density lipoprotein particle assembly GO:0034380 9.64 ABCA1 APOE
20 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.64 ABCA1 CETP
21 phosphatidylcholine metabolic process GO:0046470 9.63 CETP PON1
22 phospholipid efflux GO:0033700 9.63 ABCA1 APOE
23 positive regulation of cholesterol efflux GO:0010875 9.63 ABCA1 APOE PON1
24 regulation of protein metabolic process GO:0051246 9.62 APOE LDLR
25 high-density lipoprotein particle clearance GO:0034384 9.62 APOE LDLR
26 phospholipid transport GO:0015914 9.62 ABCA1 ABCG8 CETP LDLR
27 phospholipid homeostasis GO:0055091 9.61 ABCA1 CETP
28 very-low-density lipoprotein particle remodeling GO:0034372 9.61 APOE CETP
29 low-density lipoprotein particle remodeling GO:0034374 9.61 APOE CETP LPA
30 chylomicron remnant clearance GO:0034382 9.6 APOE LDLR
31 regulation of Cdc42 protein signal transduction GO:0032489 9.58 ABCA1 APOE
32 lipoprotein biosynthetic process GO:0042158 9.58 ABCA1 APOE
33 lipoprotein catabolic process GO:0042159 9.57 APOE LDLR
34 negative regulation of intestinal cholesterol absorption GO:0045796 9.56 ABCG5 ABCG8
35 cholesterol efflux GO:0033344 9.56 ABCA1 ABCG5 ABCG8 APOE
36 negative regulation of intestinal phytosterol absorption GO:0010949 9.55 ABCG5 ABCG8
37 cholesterol metabolic process GO:0008203 9.55 ABCA1 APOE CETP LDLR PON1
38 response to caloric restriction GO:0061771 9.54 APOE LDLR
39 intestinal cholesterol absorption GO:0030299 9.54 ABCG5 ABCG8 LDLR
40 cholesterol homeostasis GO:0042632 9.43 ABCA1 ABCG5 ABCG8 APOE CETP LDLR
41 lipid transport GO:0006869 9.17 ABCA1 ABCG5 ABCG8 APOE CETP LDLR

Molecular functions related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.63 ABCA1 ABCG5 ABCG8
2 phospholipid binding GO:0005543 9.54 ABCA1 APOE PON1
3 phospholipid transporter activity GO:0005548 9.43 ABCA1 CETP
4 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.43 ABCA1 ABCG5 ABCG8
5 apolipoprotein binding GO:0034185 9.4 ABCA1 LPA
6 cholesterol binding GO:0015485 9.33 ABCA1 APOE CETP
7 drug transmembrane transporter activity GO:0015238 9.32 ABCG5 ABCG8
8 lipid transporter activity GO:0005319 9.13 ABCA1 APOE CETP
9 cholesterol transporter activity GO:0017127 9.02 ABCA1 ABCG5 ABCG8 APOE CETP

Sources for Aortic Atherosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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