MCID: ART004
MIFTS: 47

Aortic Atherosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Aortic Atherosclerosis

MalaCards integrated aliases for Aortic Atherosclerosis:

Name: Aortic Atherosclerosis 12 15
Atherosclerosis of Aorta 12 72 33

Classifications:



External Ids:

Disease Ontology 12 DOID:10230
ICD9CM 35 440.0
SNOMED-CT 68 81817003
ICD10 33 I70.0
UMLS 72 C0155733

Summaries for Aortic Atherosclerosis

MalaCards based summary : Aortic Atherosclerosis, also known as atherosclerosis of aorta, is related to hyperlipoproteinemia, type iii and hypertriglyceridemia, familial. An important gene associated with Aortic Atherosclerosis is APOE (Apolipoprotein E), and among its related pathways/superpathways are Metabolism and Lipoprotein metabolism. The drugs Prednisolone phosphate and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include Heart, heart and endothelial, and related phenotypes are Decreased free cholesterol and Increased LDL uptake

Related Diseases for Aortic Atherosclerosis

Diseases related to Aortic Atherosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 hyperlipoproteinemia, type iii 30.4 LPA LDLR CETP APOE
2 hypertriglyceridemia, familial 30.2 CETP APOE
3 cerebral atherosclerosis 29.9 APOE ACE
4 atherosclerosis susceptibility 29.8 PON1 LPA LDLR CETP APOE ABCA1
5 carotid stenosis 29.8 SPP1 APOE ACE
6 cholelithiasis 29.7 APOE ABCG8 ABCG5
7 tangier disease 29.6 LPA CETP APOE ABCA1
8 carotid artery disease 29.5 LPA APOE ACE
9 aortic valve insufficiency 29.4 PON1 ACE
10 homozygous familial hypercholesterolemia 29.3 LDLR APOE ABCG8 ABCG5
11 coronary artery anomaly 29.2 PON1 LPA CETP ACE
12 kidney disease 29.1 SPP1 LPA APOE ACE
13 cerebrovascular disease 29.0 PON1 LDLR APOE ACE
14 coronary stenosis 28.9 PON1 CETP APOE ACE
15 stroke, ischemic 28.7 PON1 LPA APOE ACE
16 familial hyperlipidemia 28.6 PON1 LPA LDLR CETP APOE
17 lipid metabolism disorder 28.3 LPA LDLR CETP APOE ACE ABCA1
18 arteriosclerosis 28.2 SPP1 PON1 LPA APOE ACE
19 heart disease 28.1 PON1 LDLR APOE ACE ABCA1
20 arteries, anomalies of 27.9 PON1 LPA LDLR CETP APOE ACE
21 vascular disease 27.5 PON1 LPA LDLR CETP APOE ACE
22 coronary heart disease 1 27.5 PON1 LPA LDLR CETP APOE ACE
23 hypercholesterolemia, familial, 1 10.5
24 defective apolipoprotein b-100 10.4 LDLR APOE
25 leukodystrophy, hypomyelinating, 3 10.4 LPA APOE
26 sea-blue histiocyte disease 10.4 LDLR APOE
27 alzheimer disease 2 10.3 CETP APOE
28 hypobetalipoproteinemia, familial, 2 10.3 LPA CETP
29 gallbladder disease 4 10.2 ABCG8 ABCG5
30 moderate and severe traumatic brain injury 10.2 APOE ACE
31 huntington disease-like 1 10.2 LPA CETP APOE
32 smith-lemli-opitz syndrome 10.2 LDLR APOE ABCA1
33 abetalipoproteinemia 10.2 LDLR CETP APOE
34 generalized atherosclerosis 10.2 APOE ACE
35 hypolipoproteinemia 10.2 LPA APOE ABCA1
36 lipoprotein glomerulopathy 10.2 LPA LDLR APOE
37 xanthomatosis 10.2 LPA LDLR APOE
38 aortic disease 10.1
39 coronary restenosis 10.1 CETP ACE
40 macular degeneration, age-related, 1 10.1 CETP APOE ABCA1
41 peripheral vascular disease 10.1
42 familial hypercholesterolemia 10.1
43 intracranial embolism 10.1
44 niemann-pick disease, type b 10.1 LPA ABCA1
45 cardiac arrest 10.0
46 fatty liver disease 10.0
47 hemorrhage, intracerebral 10.0 APOE ACE
48 cholestasis, progressive familial intrahepatic, 1 10.0 ABCG8 ABCG5
49 hyperalphalipoproteinemia 1 10.0 LDLR CETP APOE ABCA1
50 systemic lupus erythematosus 9.9

Comorbidity relations with Aortic Atherosclerosis via Phenotypic Disease Network (PDN): (show all 14)


Acute Cystitis Aortic Valve Disease 1
Deficiency Anemia Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Mitral Valve Disease
Osteoporosis Peripheral Vascular Disease
Renal Artery Atheroma Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Aortic Atherosclerosis:



Diseases related to Aortic Atherosclerosis

Symptoms & Phenotypes for Aortic Atherosclerosis

GenomeRNAi Phenotypes related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.43 ABCA1 ABCG8 APOE CETP LDLR LPA
2 Increased LDL uptake GR00340-A-1 8.62 APOE LDLR

MGI Mouse Phenotypes related to Aortic Atherosclerosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 ABCA1 ABCG5 ACE APOE LDLR PON1
2 homeostasis/metabolism MP:0005376 9.56 ABCA1 ABCG5 ABCG8 ACE APOE LDLR
3 digestive/alimentary MP:0005381 9.55 ABCA1 ABCG5 ABCG8 APOE LDLR
4 liver/biliary system MP:0005370 9.17 ABCA1 ABCG5 ABCG8 ACE APOE LDLR

Drugs & Therapeutics for Aortic Atherosclerosis

Drugs for Aortic Atherosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 1, Phase 2 302-25-0
2
Methylprednisolone hemisuccinate Approved Phase 1, Phase 2 2921-57-5
3
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
4
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
5
Iron Approved, Experimental Phase 2 15438-31-0, 7439-89-6 23925 27284
6
Prednisolone hemisuccinate Experimental Phase 1, Phase 2 2920-86-7
7 Antiemetics Phase 1, Phase 2
8 Gastrointestinal Agents Phase 1, Phase 2
9 Hormones Phase 1, Phase 2
10 Anti-Inflammatory Agents Phase 1, Phase 2
11 Neuroprotective Agents Phase 1, Phase 2
12 glucocorticoids Phase 1, Phase 2
13 Methylprednisolone Acetate Phase 1, Phase 2
14 Peripheral Nervous System Agents Phase 1, Phase 2
15 Protective Agents Phase 1, Phase 2
16 Antineoplastic Agents, Hormonal Phase 1, Phase 2
17 Hormone Antagonists Phase 1, Phase 2
18 Autonomic Agents Phase 1, Phase 2
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
20 Prednisolone acetate Phase 1, Phase 2
21 Parenteral Nutrition Solutions Phase 2
22 Hematinics Phase 2
23 Pharmaceutical Solutions Phase 2
24 Ferrosoferric Oxide Phase 2
25
Simvastatin Approved 79902-63-9 54454
26
Ethanol Approved 64-17-5 702
27 Hydroxymethylglutaryl-CoA Reductase Inhibitors
28 Hypolipidemic Agents
29 Lipid Regulating Agents
30 Anticholesteremic Agents
31 Antimetabolites
32 Central Nervous System Depressants
33 Anti-Infective Agents, Local
34 Anti-Infective Agents
35 Tea

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Impedance Cardiography: Clinical Evaluation of Endotracheal Cardiac Output Monitor (ECOM) Completed NCT00924482 Phase 2, Phase 3
2 A Phase I/II, Single-Center, Randomized, Placebo-Controlled Study Evaluating the Therapeutic Efficacy of Intravenously Injected PEG-liposomal Prednisolone Sodium Phosphate (Nanocort®) in Subjects With Severe Inflamed Carotid or Aortic Atherosclerosis Plaques Unknown status NCT01601106 Phase 1, Phase 2 liposomal prednisolone;Placebo
3 ASSESSMENT OF CELLULAR INFLAMMATION FOLLOWING ACUTE MYOCARDIAL INFARCTION Application Of Ultrasmall Superparamagnetic Particles Of Iron Oxide Unknown status NCT01995799 Phase 2
4 Magnetic Resonance Neurological Evaluation After Right Mini-thoracotomy Mitral Valve Surgery: Trans-thoracic Versus Endoaortic Clamp Unknown status NCT02818166
5 Transesophageal MRI in Conjunction With Lipid Lowering Measures Completed NCT00125060 Simvastatin (20mg versus 80mg/day)
6 Cardiac MR of Subclinical CVD: Impact of Age Completed NCT00041418
7 Feasibility of Hand-Held-Ultrasonography in Primary Care in the Screening of Abdominal Aortic Aneurysm and Abdominal Aortic Atheromatosis. Completed NCT01679288
8 Alcohol and Atherosclerosis Pilot Study Completed NCT00786279
9 The Identification of In Vivo Angiogenesis and Fibrosis in Myocardial Infarction Using Positron Emission Tomography. Completed NCT01813045
10 The Identification of In Vivo Angiogenesis and Fibrosis in Aortic Stenosis Using Positron Emission Tomography Completed NCT01837160
11 Tea's Effect on Atherosclerosis Pilot Study (TEA Study) Completed NCT00120107 Black Tea
12 Upper Rectal Artery Embolization in the Treatment of Hemorrhoidal Disease Recruiting NCT03402282
13 Galectin-3 as a Predictor for Thromboembolic Formation in Patients With Non Valvular Atrial Fibrillation Assessed by CHA₂DS₂-VASc Scoring Not yet recruiting NCT03413072
14 Effects of Lomitapide on Carotid and Aortic Atherosclerosis in Patients Treated With Lomitapide in Usual Care (CAPTURE) Withdrawn NCT02399852 Lomitapide

Search NIH Clinical Center for Aortic Atherosclerosis

Genetic Tests for Aortic Atherosclerosis

Anatomical Context for Aortic Atherosclerosis

MalaCards organs/tissues related to Aortic Atherosclerosis:

41
Heart, Endothelial, Kidney, Smooth Muscle, Liver, Bone, Brain
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Aortic Atherosclerosis:
# Tissue Anatomical CompartmentCell Relevance
1 Heart Aortic Arch Arteries Vascular Smooth Muscle Cells Affected by disease

Publications for Aortic Atherosclerosis

Articles related to Aortic Atherosclerosis:

(show top 50) (show all 1124)
# Title Authors PMID Year
1
Impact of Aortic Atherosclerosis Burden on Outcomes of Surgical Aortic Valve Replacement. 38
31400333 2019
2
In vivo alpha-V beta-3 integrin expression in human aortic atherosclerosis. 38
31422361 2019
3
The importance of physiologic ischemia training in preventing the development of atherosclerosis: the role of endothelial progenitor cells in atherosclerotic rabbits. 38
30724819 2019
4
Neurologic Deficit After Aortic Arch Replacement: The Influence of the Aortic Atherosclerosis. 38
30710519 2019
5
Tailoring the Approach to Embolic Stroke of Undetermined Source: A Review. 38
30958521 2019
6
Sortilin promotes macrophage cholesterol accumulation and aortic atherosclerosis through lysosomal degradation of ATP-binding cassette transporter A1 protein. 38
30950489 2019
7
DNA methylation and hydroxymethylation are associated with the degree of coronary atherosclerosis in elderly patients with coronary heart disease. 38
30867120 2019
8
Effects of a Proximal Seal System on Neurologic Outcomes of Off-Pump Coronary Artery Bypass Grafting. 38
31019167 2019
9
Targeted invalidation of SR-B1 in macrophages reduces macrophage apoptosis and accelerates atherosclerosis. 38
31119270 2019
10
Estrogen-SIRT1 Axis Plays a Pivotal Role in Protecting Arteries Against Menopause-Induced Senescence and Atherosclerosis. 38
31105126 2019
11
Helper-dependent adenovirus-mediated gene transfer of a secreted LDL receptor/transferrin chimeric protein reduces aortic atherosclerosis in LDL receptor-deficient mice. 38
30700805 2019
12
Rivaroxaban Suppresses the Progression of Ischemic Cardiomyopathy in a Murine Model of Diet-Induced Myocardial Infarction. 38
30867376 2019
13
Genomic Analysis of an Obesity Paradox: A Microarray Study of the Aortas of Morbidly Obese Decedents With Mild and Severe Atherosclerosis. 38
30747767 2019
14
DENND5B Regulates Intestinal Triglyceride Absorption and Body Mass. 38
30837651 2019
15
Aortic Plaque Distribution, and Association between Aortic Plaque and Atherosclerotic Risk Factors: An Aortic Angioscopy Study. 38
30918164 2019
16
Corrigendum to "The therapeutic effect of rosuvastatin and propylthiouracil on ameliorating high-cholesterol diet-induced rabbit aortic atherosclerosis and stiffness" [Int. J. Cardiol. 227 (2017) 938-949]. 38
30384978 2019
17
Retrograde aortic blood flow as a mechanism of stroke: MR evaluation of the prevalence in a population-based study. 38
30877458 2019
18
Resolution of Primary Aortic Thrombosis after Dabigatran therapy-A New Hope for the Rare and Old Disease. 38
31280831 2019
19
Hawthorn Extract Alleviates Atherosclerosis through Regulating Inflammation and Apoptosis Related Factors: An Experimental Study. 38
30519874 2019
20
Nicotine dependence as an independent risk factor for atherosclerosis in the National Lung Screening Trial. 38
30669994 2019
21
Efficacy of Terpenoid in Attenuating Aortic Atherosclerosis in Apolipoprotein-E Deficient Mice: A Meta-Analysis of Animal Studies. 38
31392210 2019
22
Tanshinone IIA Promotes Macrophage Cholesterol Efflux and Attenuates Atherosclerosis of apoE-/- Mice by Omentin-1/ABCA1 Pathway. 38
30947667 2019
23
Renovascular Hypertension Aggravates Atherosclerosis in Cholesterol-Fed Rabbits. 38
30947215 2019
24
Maternal Dyslipidaemia in Pregnancy with Gestational Diabetes Mellitus: Possible Impact on Foetoplacental Vascular Function and Lipoproteins in the Neonatal Circulation. 38
29149816 2019
25
Never forget the aorta: a case report of IgG4-related disease causing aortitis. 38
31020187 2018
26
ADCY9 (Adenylate Cyclase Type 9) Inactivation Protects From Atherosclerosis Only in the Absence of CETP (Cholesteryl Ester Transfer Protein). 38
29674325 2018
27
Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7. 38
30243490 2018
28
Remote Effects of Transplanted Perivascular Adipose Tissue on Endothelial Function and Atherosclerosis. 38
30097828 2018
29
USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis. 38
30354204 2018
30
Hepatic Expression of PEMT, but Not Dietary Choline Supplementation, Reverses the Protection against Atherosclerosis in Pemt-/-/Ldlr-/- Mice. 38
30281112 2018
31
Quantification of aortic stiffness in stroke patients using 4D flow MRI in comparison with transesophageal echocardiography. 38
29799061 2018
32
E-selectin-targeted copolymer reduces atherosclerotic lesions, adverse cardiac remodeling, and dysfunction. 38
30165141 2018
33
The Extent of Aortic Atherosclerosis Predicts the Occurrence, Severity, and Recovery of Acute Kidney Injury After Transcatheter Aortic Valve Replacement. 38
30354779 2018
34
Cortical Hand Knob Stroke: Report of 25 Cases. 38
29567118 2018
35
Risk Factors of Contralateral Microembolic Infarctions Related to Carotid Artery Stenting. 38
29887547 2018
36
Proteomic Architecture of Human Coronary and Aortic Atherosclerosis. 38
29915101 2018
37
Massive organ embolization from primary aortic thrombosis. 38
29709406 2018
38
Atherosclerotic Disease and its Relationship to Lumbar Degenerative Disk Disease, Facet Arthritis, and Stenosis With Computed Tomography Angiography. 38
28918116 2018
39
MicroRNA-134 Promotes the Development of Atherosclerosis Via the ANGPTL4/LPL Pathway in Apolipoprotein E Knockout Mice. 38
28867683 2018
40
Pulmonary infarction secondary to pulmonary embolism: An evolving paradigm. 38
29577524 2018
41
Pioglitazone attenuates aging-related disorders in aged apolipoprotein E deficient mice. 38
29221940 2018
42
Isoquinoline Alkaloids and Indole Alkaloids Attenuate Aortic Atherosclerosis in Apolipoprotein E Deficient Mice: A Systematic Review and Meta-Analysis. 38
29922166 2018
43
Aortic atherosclerosis is a key modulator of the prognostic value of postural blood pressure changes. 38
29202333 2018
44
miR-146a deficiency in hematopoietic cells is not involved in the development of atherosclerosis. 38
29902229 2018
45
Catestatin Prevents Macrophage-Driven Atherosclerosis but Not Arterial Injury-Induced Neointimal Hyperplasia. 38
29304538 2018
46
Transesophageal echocardiographic thromboembolic risk is associated with smoking status in patients with atrial fibrillation. 38
29255510 2017
47
[Effects of simvastatin on aortic vascular endothelial cell apoptosis and Bcl-2 protein expression in a rat model of atherosclerosis]. 38
29180324 2017
48
Association of descending thoracic aortic plaque with brain atrophy and white matter hyperintensities: The Framingham Heart Study. 38
28673480 2017
49
Contrast enhancement of spectral domain optical coherence tomography using spectrum correction. 38
28898771 2017
50
Cooperative stimulation of atherogenesis by lipopolysaccharide and palmitic acid-rich high fat diet in low-density lipoprotein receptor-deficient mice. 38
28934649 2017

Variations for Aortic Atherosclerosis

Expression for Aortic Atherosclerosis

Search GEO for disease gene expression data for Aortic Atherosclerosis.

Pathways for Aortic Atherosclerosis

Pathways related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 PON1 LPA LDLR CETP APOE ABCG8
2
Show member pathways
12.04 LPA LDLR CETP APOE ABCG8 ABCG5
3
Show member pathways
11.97 LDLR APOE ABCA1
4 11.36 LDLR ABCG8 ABCG5
5
Show member pathways
11.24 LPA LDLR CETP APOE ABCG8 ABCG5
6 11.16 SPP1 APOE
7 11.14 ABCG8 ABCG5
8
Show member pathways
11.08 ABCG8 ABCG5 ABCA1
9 11.02 ABCG5 ABCA1
10 10.84 LDLR APOE ACE
11 10.78 CETP ABCA1
12 10.65 LDLR ABCA1

GO Terms for Aortic Atherosclerosis

Cellular components related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 SPP1 PON1 LPA CETP APOE ACE
2 extracellular space GO:0005615 9.8 SPP1 PON1 MIR19B1 CETP APOE ACE
3 receptor complex GO:0043235 9.54 LDLR ABCG8 ABCG5
4 blood microparticle GO:0072562 9.43 PON1 MIR19B1 APOE
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.4 LDLR APOE
6 low-density lipoprotein particle GO:0034362 9.16 LDLR APOE
7 ATP-binding cassette (ABC) transporter complex GO:0043190 8.96 ABCG8 ABCG5
8 high-density lipoprotein particle GO:0034364 8.8 PON1 CETP APOE

Biological processes related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.91 PON1 LPA LDLR CETP APOE ABCA1
2 negative regulation of gene expression GO:0010629 9.89 MIR19B1 LDLR APOE ACE
3 steroid metabolic process GO:0008202 9.81 LDLR CETP APOE ABCA1
4 response to nutrient GO:0007584 9.79 ABCG8 ABCG5 ABCA1
5 cholesterol transport GO:0030301 9.7 LDLR CETP ABCA1
6 lipid homeostasis GO:0055088 9.68 CETP APOE
7 triglyceride metabolic process GO:0006641 9.68 CETP APOE
8 excretion GO:0007588 9.68 ABCG8 ABCG5
9 long-term memory GO:0007616 9.67 LDLR APOE
10 triglyceride homeostasis GO:0070328 9.67 CETP APOE
11 lipoprotein metabolic process GO:0042157 9.67 LDLR APOE ABCA1
12 cellular response to low-density lipoprotein particle stimulus GO:0071404 9.66 LDLR ABCA1
13 high-density lipoprotein particle remodeling GO:0034375 9.66 CETP APOE
14 regulation of cholesterol metabolic process GO:0090181 9.65 LDLR APOE
15 phosphatidylcholine metabolic process GO:0046470 9.65 PON1 CETP
16 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.65 CETP ABCA1
17 reverse cholesterol transport GO:0043691 9.65 CETP APOE ABCA1
18 high-density lipoprotein particle assembly GO:0034380 9.64 APOE ABCA1
19 regulation of protein metabolic process GO:0051246 9.64 LDLR APOE
20 phospholipid efflux GO:0033700 9.63 APOE ABCA1
21 phospholipid homeostasis GO:0055091 9.63 CETP ABCA1
22 positive regulation of cholesterol efflux GO:0010875 9.63 PON1 APOE ABCA1
23 high-density lipoprotein particle clearance GO:0034384 9.62 LDLR APOE
24 very-low-density lipoprotein particle remodeling GO:0034372 9.62 CETP APOE
25 phospholipid transport GO:0015914 9.62 LDLR CETP ABCG8 ABCA1
26 chylomicron remnant clearance GO:0034382 9.61 LDLR APOE
27 regulation of Cdc42 protein signal transduction GO:0032489 9.6 APOE ABCA1
28 lipoprotein biosynthetic process GO:0042158 9.58 APOE ABCA1
29 regulation of plasma lipoprotein particle levels GO:0097006 9.58 MIR19B1 APOE
30 low-density lipoprotein particle remodeling GO:0034374 9.58 LPA CETP APOE
31 lipoprotein catabolic process GO:0042159 9.57 LDLR APOE
32 response to caloric restriction GO:0061771 9.56 LDLR APOE
33 cholesterol efflux GO:0033344 9.56 APOE ABCG8 ABCG5 ABCA1
34 negative regulation of intestinal phytosterol absorption GO:0010949 9.55 ABCG8 ABCG5
35 cholesterol metabolic process GO:0008203 9.55 PON1 LDLR CETP APOE ABCA1
36 negative regulation of intestinal cholesterol absorption GO:0045796 9.54 ABCG8 ABCG5
37 intestinal cholesterol absorption GO:0030299 9.54 LDLR ABCG8 ABCG5
38 lipid transport GO:0006869 9.5 LPA LDLR CETP APOE ABCG8 ABCG5
39 positive regulation of endocytosis GO:0045807 9.36 APOE
40 cholesterol homeostasis GO:0042632 9.17 MIR19B1 LDLR CETP APOE ABCG8 ABCG5

Molecular functions related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.61 ABCG8 ABCG5 ABCA1
2 phospholipid binding GO:0005543 9.5 PON1 APOE ABCA1
3 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.43 ABCG8 ABCG5 ABCA1
4 phospholipid transporter activity GO:0005548 9.4 CETP ABCA1
5 apolipoprotein binding GO:0034185 9.37 LPA ABCA1
6 cholesterol binding GO:0015485 9.33 CETP APOE ABCA1
7 lipid transporter activity GO:0005319 9.13 CETP APOE ABCA1
8 cholesterol transporter activity GO:0017127 9.02 CETP APOE ABCG8 ABCG5 ABCA1

Sources for Aortic Atherosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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