MCID: ART004
MIFTS: 47

Aortic Atherosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Aortic Atherosclerosis

MalaCards integrated aliases for Aortic Atherosclerosis:

Name: Aortic Atherosclerosis 12 15
Atherosclerosis of Aorta 12 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:10230
ICD9CM 34 440.0
SNOMED-CT 67 81817003
ICD10 32 I70.0
UMLS 71 C0155733

Summaries for Aortic Atherosclerosis

MalaCards based summary : Aortic Atherosclerosis, also known as atherosclerosis of aorta, is related to hyperlipoproteinemia, type iii and arteries, anomalies of. An important gene associated with Aortic Atherosclerosis is APOE (Apolipoprotein E), and among its related pathways/superpathways are Metabolism and Lipoprotein metabolism. The drugs Prednisolone phosphate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include Heart, endothelial and smooth muscle, and related phenotypes are Decreased free cholesterol and Decreased LDL uptake

Related Diseases for Aortic Atherosclerosis

Diseases related to Aortic Atherosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 187)
# Related Disease Score Top Affiliating Genes
1 hyperlipoproteinemia, type iii 30.8 LPL LPA LDLR CETP APOE
2 arteries, anomalies of 30.7 LPA APOE ADIPOQ ACE
3 lipoprotein quantitative trait locus 30.5 PON1 LPA IL10 ACE
4 peripheral vascular disease 30.4 PLTP LPA CETP ACE
5 hypertriglyceridemia, familial 30.3 LPL CETP APOE
6 cerebral atherosclerosis 30.3 LPA APOE ACE
7 hypercholesterolemia, familial, 1 30.2 LPL LPA LDLR CETP APOE ACE
8 chlamydia pneumonia 30.2 TLR4 IL10 APOE
9 aortic aneurysm, familial abdominal, 1 30.2 CETP APOE ACE
10 cholelithiasis 30.2 APOE ABCG8 ABCG5
11 homozygous familial hypercholesterolemia 29.9 LDLR APOE ABCG8 ABCG5 ABCA1
12 aortic valve disease 2 29.9 SPP1 LPA ACE
13 pulmonary disease, chronic obstructive 29.8 TLR4 MPO IL10 ACE
14 uremia 29.7 SPP1 PON1 LPL ACE
15 periodontitis 29.6 TLR4 SPP1 MPO IL10
16 coronary stenosis 29.6 TLR4 PON1 LPL CETP APOE ADIPOQ
17 non-alcoholic steatohepatitis 29.6 TLR4 APOE ADIPOQ
18 carotid artery disease 29.5 PON1 LRP1 LPA APOE ACE
19 kidney disease 29.5 SPP1 PON1 LPA CETP APOE ADIPOQ
20 carotid stenosis 29.4 SPP1 MPO LPA IL10 APOE ADIPOQ
21 stroke, ischemic 29.2 TLR4 PON1 PLA2G7 LPA LDLR APOE
22 tangier disease 29.2 PLTP LPL LPA CETP APOE ABCG8
23 atherosclerosis susceptibility 29.1 TLR4 PON1 PLTP PLA2G7 MPO LPL
24 familial hyperlipidemia 29.1 PON1 LPL LPA LDLR CETP APOE
25 cerebrovascular disease 28.8 TLR4 SPP1 PON1 LPL LPA LDLR
26 arteriosclerosis 28.8 TLR4 SPP1 PON1 LPL LPA LDLR
27 coronary heart disease 1 28.7 PON1 PLA2G7 LPL LPA LDLR CETP
28 lipid metabolism disorder 28.1 PON1 PLTP PLA2G7 LPL LPA LDLR
29 systemic lupus erythematosus 28.1 TLR4 SPP1 PON1 MPO IL10 ADIPOQ
30 chronic kidney disease 27.8 TLR4 SPP1 PON1 PLA2G7 MPO LPL
31 heart disease 27.7 TLR4 PON1 MSTN LPL LPA LDLR
32 vascular disease 27.6 TLR4 SPP1 PON1 PLA2G7 MPO LPL
33 familial hypercholesterolemia 27.6 PON1 PLA2G7 MPO LRP1 LPL LPA
34 hypertension, essential 27.1 TLR4 SPP1 PON1 PLA2G7 MPO LPL
35 diabetes mellitus 27.0 TLR4 SPP1 PON1 PLTP PLA2G7 MPO
36 moderate and severe traumatic brain injury 10.5 APOE ACE
37 hypercholesterolemia, familial, 2 10.5 LDLR APOE
38 defective apolipoprotein b-100 10.5 LDLR APOE
39 sitosterolemia 2 10.5 ABCG8 ABCG5
40 sitosterolemia 1 10.4 ABCG8 ABCG5
41 lipoprotein glomerulopathy 10.4 LPA LDLR APOE
42 hepatic lipase deficiency 10.4 LPL APOE
43 platelet glycoprotein iv deficiency 10.4 TLR4 LPL APOE
44 silent myocardial infarction 10.4 LPA ACE
45 sitosterolemia 10.4 ABCG8 ABCG5 ABCA1
46 multiple cranial nerve palsy 10.3 MPO ACE
47 apnea, obstructive sleep 10.3 APOE ADIPOQ ACE
48 huntington disease-like 1 10.3 LPA CETP APOE ABCA1
49 hyperlipoproteinemia, type iv 10.3 LPL LPA CETP APOE
50 niemann-pick disease, type c1 10.3 IL10 ABCG5 ABCA1

Comorbidity relations with Aortic Atherosclerosis via Phenotypic Disease Network (PDN): (show all 14)


Acute Cystitis Aortic Valve Disease 1
Deficiency Anemia Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Mitral Valve Disease
Osteoporosis Peripheral Vascular Disease
Renal Artery Atheroma Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Aortic Atherosclerosis:



Diseases related to Aortic Atherosclerosis

Symptoms & Phenotypes for Aortic Atherosclerosis

GenomeRNAi Phenotypes related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.13 ABCA1 ABCG8 LDLR
2 Decreased LDL uptake GR00340-A-1 8.62 LDLR LPL

MGI Mouse Phenotypes related to Aortic Atherosclerosis:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.36 ABCA1 ABCG5 ACE ADIPOQ APOE IL10
2 cellular MP:0005384 10.34 ABCA1 ABCG5 ABCG8 ADIPOQ APOE IL10
3 homeostasis/metabolism MP:0005376 10.31 ABCA1 ABCG5 ABCG8 ACE ADIPOQ APOE
4 behavior/neurological MP:0005386 10.3 ABCA1 ABCG5 ACE ADIPOQ APOE IL10
5 growth/size/body region MP:0005378 10.23 ABCA1 ABCG5 ACE ADIPOQ APOE IL10
6 hematopoietic system MP:0005397 10.21 ABCA1 ABCG5 ABCG8 ACE ADIPOQ APOE
7 immune system MP:0005387 10.21 ABCA1 ABCG5 ABCG8 ACE ADIPOQ APOE
8 adipose tissue MP:0005375 10.14 ACE ADIPOQ APOE LDLR LPL LRP1
9 liver/biliary system MP:0005370 10.13 ABCA1 ABCG5 ABCG8 ACE ADIPOQ APOE
10 mortality/aging MP:0010768 10.1 ABCA1 ABCG5 ACE ADIPOQ APOE IL10
11 digestive/alimentary MP:0005381 10.08 ABCA1 ABCG5 ABCG8 APOE IL10 LDLR
12 muscle MP:0005369 9.93 ABCA1 ABCG5 ADIPOQ APOE IL10 LDLR
13 reproductive system MP:0005389 9.65 ABCA1 ABCG5 ABCG8 ACE APOE IL10
14 skeleton MP:0005390 9.28 ABCA1 ADIPOQ APOE IL10 LRP1 MSTN

Drugs & Therapeutics for Aortic Atherosclerosis

Drugs for Aortic Atherosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 1, Phase 2 302-25-0
2
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
3
Methylprednisolone hemisuccinate Approved Phase 1, Phase 2 2921-57-5
4 Prednisolone acetate Approved, Vet_approved Phase 1, Phase 2 52-21-1
5
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
6
Iron Approved, Experimental Phase 2 15438-31-0, 7439-89-6 27284 23925
7
Prednisolone hemisuccinate Experimental Phase 1, Phase 2 2920-86-7
8 Hormones Phase 1, Phase 2
9 Methylprednisolone Acetate Phase 1, Phase 2
10 glucocorticoids Phase 1, Phase 2
11 Hormone Antagonists Phase 1, Phase 2
12 Antineoplastic Agents, Hormonal Phase 1, Phase 2
13 Anti-Inflammatory Agents Phase 1, Phase 2
14 Hematinics Phase 2
15 Ferrosoferric Oxide Phase 2
16 Pharmaceutical Solutions Phase 2
17 Parenteral Nutrition Solutions Phase 2
18
Simvastatin Approved 79902-63-9 54454
19
Ethanol Approved 64-17-5 702
20 Hypolipidemic Agents
21 Lipid Regulating Agents
22 Hydroxymethylglutaryl-CoA Reductase Inhibitors
23 Anticholesteremic Agents
24 Antimetabolites
25 Anti-Infective Agents, Local
26 Anti-Infective Agents
27 Tea

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Impedance Cardiography: Clinical Evaluation of Endotracheal Cardiac Output Monitor (ECOM) Completed NCT00924482 Phase 2, Phase 3
2 A Phase I/II, Single-Center, Randomized, Placebo-Controlled Study Evaluating the Therapeutic Efficacy of Intravenously Injected PEG-liposomal Prednisolone Sodium Phosphate (Nanocort®) in Subjects With Severe Inflamed Carotid or Aortic Atherosclerosis Plaques Unknown status NCT01601106 Phase 1, Phase 2 liposomal prednisolone;Placebo
3 ASSESSMENT OF CELLULAR INFLAMMATION FOLLOWING ACUTE MYOCARDIAL INFARCTION Application Of Ultrasmall Superparamagnetic Particles Of Iron Oxide Unknown status NCT01995799 Phase 2
4 Galectin-3 as a Predictor for Thromboembolic Formation in Patients With Non Valvular Atrial Fibrillation Assessed by CHA₂DS₂-VASc Scoring Unknown status NCT03413072
5 Magnetic Resonance Neurological Evaluation After Right Mini-thoracotomy Mitral Valve Surgery: Trans-thoracic Versus Endoaortic Clamp Unknown status NCT02818166
6 Transesophageal MRI in Conjunction With Lipid Lowering Measures Completed NCT00125060 Simvastatin (20mg versus 80mg/day)
7 Cardiac MR of Subclinical CVD: Impact of Age Completed NCT00041418
8 Feasibility of Hand-Held-Ultrasonography in Primary Care in the Screening of Abdominal Aortic Aneurysm and Abdominal Aortic Atheromatosis. Completed NCT01679288
9 Alcohol and Atherosclerosis Pilot Study Completed NCT00786279
10 The Identification of In Vivo Angiogenesis and Fibrosis in Aortic Stenosis Using Positron Emission Tomography Completed NCT01837160
11 Tea's Effect on Atherosclerosis Pilot Study (TEA Study) Completed NCT00120107 Black Tea
12 The Identification of In Vivo Angiogenesis and Fibrosis in Myocardial Infarction Using Positron Emission Tomography. Completed NCT01813045
13 Upper Rectal Artery Embolization in the Treatment of Hemorrhoidal Disease Recruiting NCT03402282
14 Effects of Lomitapide on Carotid and Aortic Atherosclerosis in Patients Treated With Lomitapide in Usual Care (CAPTURE) Withdrawn NCT02399852 Lomitapide

Search NIH Clinical Center for Aortic Atherosclerosis

Genetic Tests for Aortic Atherosclerosis

Anatomical Context for Aortic Atherosclerosis

MalaCards organs/tissues related to Aortic Atherosclerosis:

40
Heart, Endothelial, Smooth Muscle, Kidney, Liver, Bone, Brain
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Aortic Atherosclerosis:
# Tissue Anatomical CompartmentCell Relevance
1 Heart Aortic Arch Arteries Vascular Smooth Muscle Cells Affected by disease

Publications for Aortic Atherosclerosis

Articles related to Aortic Atherosclerosis:

(show top 50) (show all 1137)
# Title Authors PMID Year
1
Inhibition of JAK2 Suppresses Myelopoiesis and Atherosclerosis in Apoe-/- Mice. 61
32086626 2020
2
Spontaneous ruptured aortic plaque and injuries: insights for aging and acute aortic syndrome from non-obstructive general angioscopy. 61
31882197 2020
3
Targeted invalidation of SR-B1 in macrophages reduces macrophage apoptosis and accelerates atherosclerosis. 61
31119270 2020
4
Aortic atherosclerosis complicated by retroperitoneal fibrosis treated only by optimal cardiovascular risk factors management. 61
32057325 2020
5
Impact of Aortic Atherosclerosis Burden on Outcomes of Surgical Aortic Valve Replacement. 61
31400333 2020
6
Estrogen-SIRT1 Axis Plays a Pivotal Role in Protecting Arteries Against Menopause-Induced Senescence and Atherosclerosis. 61
31105126 2020
7
Macrophages in Atherosclerosis Regression. 61
31722535 2020
8
Chronic Staphylococcus aureus Superantigen Toxic Shock Syndrome Toxin-1 Exposure Accelerates the Progression of Atherosclerosis in Rabbits. 61
31903005 2020
9
Efficacy of Curcumin on Aortic Atherosclerosis: A Systematic Review and Meta-Analysis in Mouse Studies and Insights into Possible Mechanisms. 61
31998433 2020
10
Involvement of Low-Density Lipoprotein Receptor in the Pathogenesis of Pulmonary Hypertension. 61
31914876 2020
11
In vivo alpha-V beta-3 integrin expression in human aortic atherosclerosis. 61
31422361 2019
12
Myricitrin exhibits anti-atherosclerotic and anti-hyperlipidemic effects in diet-induced hypercholesterolemic rats. 61
31865448 2019
13
[Metformin inhibits aortic atherosclerosis in mice by regulating actin skeleton in vascular smooth muscle cells]. 61
31852643 2019
14
Aortic Plaque Distribution, and Association between Aortic Plaque and Atherosclerotic Risk Factors: An Aortic Angioscopy Study. 61
30918164 2019
15
The Effects of Dimethyl Fumarate on Atherosclerosis in the Apolipoprotein E-Deficient Mouse Model with Streptozotocin-Induced Hyperglycemia Mediated By the Nuclear Factor Erythroid 2-Related Factor 2/Antioxidant Response Element (Nrf2/ARE) Signaling Pathway. 61
31645538 2019
16
Retrograde aortic blood flow as a mechanism of stroke: MR evaluation of the prevalence in a population-based study. 61
30877458 2019
17
Rivaroxaban Suppresses the Progression of Ischemic Cardiomyopathy in a Murine Model of Diet-Induced Myocardial Infarction. 61
30867376 2019
18
Stimulation of Collateral Vessel Growth by Inhibition of Galectin 2 in Mice Using a Single-Domain Llama-Derived Antibody. 61
31594443 2019
19
Impact of shaggy aorta on outcomes of open thoracoabdominal aortic aneurysm repair. 61
31587889 2019
20
The importance of physiologic ischemia training in preventing the development of atherosclerosis: the role of endothelial progenitor cells in atherosclerotic rabbits. 61
30724819 2019
21
Tailoring the Approach to Embolic Stroke of Undetermined Source: A Review. 61
30958521 2019
22
Neurologic Deficit After Aortic Arch Replacement: The Influence of the Aortic Atherosclerosis. 61
30710519 2019
23
Sortilin promotes macrophage cholesterol accumulation and aortic atherosclerosis through lysosomal degradation of ATP-binding cassette transporter A1 protein. 61
30950489 2019
24
DNA methylation and hydroxymethylation are associated with the degree of coronary atherosclerosis in elderly patients with coronary heart disease. 61
30867120 2019
25
Effects of a Proximal Seal System on Neurologic Outcomes of Off-Pump Coronary Artery Bypass Grafting. 61
31019167 2019
26
Helper-dependent adenovirus-mediated gene transfer of a secreted LDL receptor/transferrin chimeric protein reduces aortic atherosclerosis in LDL receptor-deficient mice. 61
30700805 2019
27
Genomic Analysis of an Obesity Paradox: A Microarray Study of the Aortas of Morbidly Obese Decedents With Mild and Severe Atherosclerosis. 61
30747767 2019
28
DENND5B Regulates Intestinal Triglyceride Absorption and Body Mass. 61
30837651 2019
29
Corrigendum to "The therapeutic effect of rosuvastatin and propylthiouracil on ameliorating high-cholesterol diet-induced rabbit aortic atherosclerosis and stiffness" [Int. J. Cardiol. 227 (2017) 938-949]. 61
30384978 2019
30
Resolution of Primary Aortic Thrombosis after Dabigatran therapy-A New Hope for the Rare and Old Disease. 61
31280831 2019
31
Hawthorn Extract Alleviates Atherosclerosis through Regulating Inflammation and Apoptosis Related Factors: An Experimental Study. 61
30519874 2019
32
Nicotine dependence as an independent risk factor for atherosclerosis in the National Lung Screening Trial. 61
30669994 2019
33
Adipokine Chemerin Stimulates Progression of Atherosclerosis in ApoE-/- Mice. 61
31781638 2019
34
Renovascular Hypertension Aggravates Atherosclerosis in Cholesterol-Fed Rabbits. 61
30947215 2019
35
Tanshinone IIA Promotes Macrophage Cholesterol Efflux and Attenuates Atherosclerosis of apoE-/- Mice by Omentin-1/ABCA1 Pathway. 61
30947667 2019
36
Efficacy of Terpenoid in Attenuating Aortic Atherosclerosis in Apolipoprotein-E Deficient Mice: A Meta-Analysis of Animal Studies. 61
31392210 2019
37
Maternal Dyslipidaemia in Pregnancy with Gestational Diabetes Mellitus: Possible Impact on Foetoplacental Vascular Function and Lipoproteins in the Neonatal Circulation. 61
29149816 2019
38
Never forget the aorta: a case report of IgG4-related disease causing aortitis. 61
31020187 2018
39
Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7. 61
30243490 2018
40
USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis. 61
30354204 2018
41
ADCY9 (Adenylate Cyclase Type 9) Inactivation Protects From Atherosclerosis Only in the Absence of CETP (Cholesteryl Ester Transfer Protein). 61
29674325 2018
42
Hepatic Expression of PEMT, but Not Dietary Choline Supplementation, Reverses the Protection against Atherosclerosis in Pemt-/-/Ldlr-/- Mice. 61
30281112 2018
43
Remote Effects of Transplanted Perivascular Adipose Tissue on Endothelial Function and Atherosclerosis. 61
30097828 2018
44
E-selectin-targeted copolymer reduces atherosclerotic lesions, adverse cardiac remodeling, and dysfunction. 61
30165141 2018
45
Quantification of aortic stiffness in stroke patients using 4D flow MRI in comparison with transesophageal echocardiography. 61
29799061 2018
46
The Extent of Aortic Atherosclerosis Predicts the Occurrence, Severity, and Recovery of Acute Kidney Injury After Transcatheter Aortic Valve Replacement. 61
30354779 2018
47
Cortical Hand Knob Stroke: Report of 25 Cases. 61
29567118 2018
48
Risk Factors of Contralateral Microembolic Infarctions Related to Carotid Artery Stenting. 61
29887547 2018
49
Proteomic Architecture of Human Coronary and Aortic Atherosclerosis. 61
29915101 2018
50
Massive organ embolization from primary aortic thrombosis. 61
29709406 2018

Variations for Aortic Atherosclerosis

Expression for Aortic Atherosclerosis

Search GEO for disease gene expression data for Aortic Atherosclerosis.

Pathways for Aortic Atherosclerosis

Pathways related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 PON1 PLTP PLA2G7 LRP1 LPL LPA
2
Show member pathways
12.14 PLTP LPL LPA LDLR CETP APOE
3
Show member pathways
12.11 MPO LDLR APOE ABCA1
4
Show member pathways
12.09 LRP1 LPL LDLR APOE
5 11.68 SPP1 LPL ADIPOQ
6 11.64 LDLR ABCG8 ABCG5
7 11.56 PLTP LPL ADIPOQ
8
Show member pathways
11.39 PLTP LRP1 LPL LPA LDLR CETP
9 11.31 TLR4 LRP1 IL10
10 11.26 MPO LRP1 LPA
11
Show member pathways
11.21 ABCG8 ABCG5 ABCA1
12 11.14 LPL ABCG8 ABCG5
13 11.06 TLR4 LRP1 LDLR APOE ACE

GO Terms for Aortic Atherosclerosis

Cellular components related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 SPP1 PON1 PLTP PLA2G7 MSTN MPO
2 extracellular space GO:0005615 9.77 SPP1 PON1 PLTP PLA2G7 MSTN MPO
3 early endosome GO:0005769 9.76 TLR4 LRP1 LDLR APOE
4 receptor complex GO:0043235 9.72 TLR4 LRP1 LDLR ABCG8 ABCG5
5 apical part of cell GO:0045177 9.58 LRP1 LDLR ABCG5
6 chylomicron GO:0042627 9.43 LPL APOE
7 low-density lipoprotein particle GO:0034362 9.43 PLA2G7 LDLR APOE
8 ATP-binding cassette (ABC) transporter complex GO:0043190 9.37 ABCG8 ABCG5
9 high-density lipoprotein particle GO:0034364 9.02 PON1 PLTP PLA2G7 CETP APOE

Biological processes related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 10.07 PON1 PLTP PLA2G7 LRP1 LPL LPA
2 response to drug GO:0042493 10.01 LPL IL10 ADIPOQ ABCG8 ABCG5 ABCA1
3 steroid metabolic process GO:0008202 9.93 LDLR CETP APOE ABCA1
4 positive regulation of inflammatory response GO:0050729 9.9 TLR4 PLA2G7 LPL LDLR
5 response to nutrient GO:0007584 9.89 ADIPOQ ABCG8 ABCG5 ABCA1
6 cholesterol metabolic process GO:0008203 9.89 PON1 LDLR CETP APOE ABCA1
7 phagocytosis GO:0006909 9.87 TLR4 LRP1 LDLR
8 response to glucocorticoid GO:0051384 9.85 MSTN IL10 ADIPOQ
9 retinoid metabolic process GO:0001523 9.85 LRP1 LPL APOE
10 negative regulation of tumor necrosis factor production GO:0032720 9.84 TLR4 IL10 ADIPOQ
11 triglyceride metabolic process GO:0006641 9.82 LPL CETP APOE
12 triglyceride homeostasis GO:0070328 9.8 LPL CETP APOE
13 phospholipid transport GO:0015914 9.8 PLTP LDLR CETP ABCG8 ABCA1
14 intermembrane lipid transfer GO:0120009 9.8 PLTP CETP APOE ABCG8 ABCG5 ABCA1
15 cholesterol transport GO:0030301 9.78 LDLR CETP ABCA1
16 reverse cholesterol transport GO:0043691 9.76 CETP APOE ABCA1
17 lipoprotein metabolic process GO:0042157 9.76 LRP1 LDLR APOE ABCA1
18 lipid transport GO:0006869 9.76 PLTP LPA LDLR CETP APOE ABCG8
19 sterol transport GO:0015918 9.75 PLTP ABCG8 ABCG5
20 high-density lipoprotein particle remodeling GO:0034375 9.74 PLTP CETP APOE
21 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.73 CETP ADIPOQ ABCA1
22 cholesterol efflux GO:0033344 9.73 APOE ABCG8 ABCG5 ABCA1
23 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.72 TLR4 LRP1 LPL
24 regulation of cholesterol metabolic process GO:0090181 9.71 LDLR APOE
25 amyloid-beta clearance GO:0097242 9.71 LRP1 LDLR
26 high-density lipoprotein particle assembly GO:0034380 9.71 APOE ABCA1
27 phospholipid homeostasis GO:0055091 9.71 CETP ABCA1
28 phospholipid efflux GO:0033700 9.7 APOE ABCA1
29 high-density lipoprotein particle clearance GO:0034384 9.7 LDLR APOE
30 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.7 IL10 ADIPOQ
31 regulation of protein metabolic process GO:0051246 9.7 LDLR APOE
32 intestinal cholesterol absorption GO:0030299 9.7 LDLR ABCG8 ABCG5
33 positive regulation of MHC class II biosynthetic process GO:0045348 9.69 TLR4 IL10
34 interleukin-1 beta secretion GO:0050702 9.69 TLR4 ABCA1
35 very-low-density lipoprotein particle remodeling GO:0034372 9.69 LPL CETP APOE
36 chylomicron remnant clearance GO:0034382 9.68 LDLR APOE
37 chylomicron remodeling GO:0034371 9.68 LPL APOE
38 positive regulation of amyloid-beta clearance GO:1900223 9.67 LRP1 APOE
39 amyloid-beta clearance by cellular catabolic process GO:0150094 9.67 LRP1 LDLR
40 regulation of Cdc42 protein signal transduction GO:0032489 9.67 APOE ABCA1
41 lipoprotein biosynthetic process GO:0042158 9.66 APOE ABCA1
42 negative regulation of amyloid fibril formation GO:1905907 9.65 LDLR APOE
43 regulation of plasma lipoprotein particle levels GO:0097006 9.65 MIR19B1 APOE
44 lipoprotein catabolic process GO:0042159 9.65 LDLR APOE
45 positive regulation of chemokine (C-C motif) ligand 2 secretion GO:1904209 9.65 TLR4 LRP1 LPL
46 low-density lipoprotein particle remodeling GO:0034374 9.65 PLA2G7 MPO LPA CETP APOE
47 positive regulation of lysosomal protein catabolic process GO:1905167 9.64 LRP1 LDLR
48 response to caloric restriction GO:0061771 9.62 LDLR APOE
49 negative regulation of intestinal cholesterol absorption GO:0045796 9.62 ABCG8 ABCG5
50 negative regulation of intestinal phytosterol absorption GO:0010949 9.61 ABCG8 ABCG5

Molecular functions related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.85 TLR4 MSTN LPL APOE ADIPOQ ABCA1
2 cytokine activity GO:0005125 9.81 SPP1 MSTN IL10 ADIPOQ
3 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.63 ABCG8 ABCG5 ABCA1
4 amyloid-beta binding GO:0001540 9.62 TLR4 LRP1 LDLR APOE
5 phosphatidylcholine binding GO:0031210 9.61 PLTP CETP ABCA1
6 heparin binding GO:0008201 9.55 MSTN MPO LPL LPA APOE
7 phospholipid transporter activity GO:0005548 9.54 CETP ABCA1
8 low-density lipoprotein particle receptor activity GO:0005041 9.52 LRP1 LDLR
9 lipoprotein particle binding GO:0071813 9.49 LPL APOE
10 clathrin heavy chain binding GO:0032050 9.48 LRP1 LDLR
11 heparan sulfate proteoglycan binding GO:0043395 9.43 LRP1 LPL APOE
12 triglyceride binding GO:0017129 9.4 LPL CETP
13 apolipoprotein binding GO:0034185 9.26 LRP1 LPL LPA ABCA1
14 intermembrane cholesterol transfer activity GO:0120020 9.1 PLTP CETP APOE ABCG8 ABCG5 ABCA1

Sources for Aortic Atherosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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