MCID: ART031
MIFTS: 49

Aortic Coarctation

Categories: Rare diseases

Aliases & Classifications for Aortic Coarctation

MalaCards integrated aliases for Aortic Coarctation:

Name: Aortic Coarctation 54 17
Coarctation of the Aorta 54

Classifications:



External Ids:

Summaries for Aortic Coarctation

MalaCards based summary : Aortic Coarctation, also known as coarctation of the aorta, is related to aortic valve disease 1 and fibromuscular dysplasia. An important gene associated with Aortic Coarctation is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Signaling by GPCR and Aldosterone synthesis and secretion. The drugs Bupivacaine and Sevoflurane have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and spinal cord, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 77 Coarctation of the aorta (CoA or CoAo), also called aortic narrowing, is a congenital condition whereby... more...

Related Diseases for Aortic Coarctation

Diseases related to Aortic Coarctation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 271)
# Related Disease Score Top Affiliating Genes
1 aortic valve disease 1 30.5 ACE FBN1 NOTCH1
2 fibromuscular dysplasia 30.4 ACE AGT AGTR1
3 pediatric hypertension 30.4 ACE AGT
4 mitral valve insufficiency 30.4 ACE FBN1
5 ischemia 30.3 ACE EDN1 NOS3
6 postural orthostatic tachycardia syndrome 30.1 AGTR1 FBN1
7 congestive heart failure 30.0 ACE ADRB1 ADRB2 AGTR1 EDN1
8 meningococcal infection 29.9 ADRB1 ADRB2 AGT AGTR1
9 ischemic heart disease 29.9 ACE AGTR1 NOS3
10 acute myocardial infarction 29.8 ACE ADRB1 AGTR1 EDN1
11 arteries, anomalies of 29.8 ACE AGT AGTR1 EDN1 NOS3
12 hypercholesterolemia, familial 29.8 ACE AGT NOS3
13 angina pectoris 29.8 ACE EDN1 NOS3
14 coronary heart disease 1 29.8 ACE ADRB1 NOS3
15 pulmonary edema 29.8 ACE EDN1 NOS3
16 renovascular hypertension 29.8 ACE AGTR1 EDN1 NOS3
17 tetralogy of fallot 29.7 EDN1 FBN1 NOTCH1
18 coronary artery anomaly 29.7 ACE ADRB1 ADRB2 AGTR1 EDN1 NOS3
19 pulmonary hypertension 29.5 ACE EDN1 NOS3
20 pre-eclampsia 29.4 AGT AGTR1 EDN1 NOS3
21 stroke, ischemic 29.4 ACE AGTR1 FBN1 NOS3
22 mitral valve disease 29.2 ACE AGT AGTR1 FBN1 NOS3
23 heart disease 28.9 ACE ADRB1 AGTR1 EDN1 NOS3 NOTCH1
24 orthostatic intolerance 28.9 ADRB1 ADRB2 AGTR1 EDN1 FBN1 NOS3
25 myocardial infarction 28.8 ACE ADRB1 ADRB2 AGT AGTR1 EDN1
26 dilated cardiomyopathy 28.4 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
27 hypertension, essential 28.0 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
28 cardiac septal defects with coarctation of the aorta 12.4
29 phace syndrome 11.6
30 congenital heart defects, hamartomas of tongue, and polysyndactyly 11.5
31 tricuspid atresia 11.3
32 cardiac, facial, and digital anomalies with developmental delay 11.3
33 heart defect-tongue hamartoma-polysyndactyly syndrome 11.2
34 ventricular septal defect 10.5
35 patent ductus arteriosus 1 10.5
36 aortic aneurysm 10.4
37 resting heart rate, variation in 10.4 ADRB1 ADRB2
38 ocular hypotension 10.3 ADRB1 ADRB2
39 rere-related disorders 10.3
40 perinephritis 10.3 ADRB2 EDN1
41 hypertensive nephropathy 10.3 ACE AGTR1
42 hypoaldosteronism 10.3 ACE CYP11B2
43 raynaud phenomenon 10.2 AGTR1 EDN1
44 idiopathic edema 10.2 ACE EDN1
45 nephrosclerosis 10.2 ACE ADRB1 AGTR1
46 posterior urethral valves 10.2 ACE AGT AGTR1
47 microvascular complications of diabetes 3 10.2 ACE AGT AGTR1
48 anuria 10.2 ACE AGT AGTR1
49 myocardial stunning 10.2 AGTR1 EDN1
50 systolic heart failure 10.2 ACE ADRB1 EDN1

Graphical network of the top 20 diseases related to Aortic Coarctation:



Diseases related to Aortic Coarctation

Symptoms & Phenotypes for Aortic Coarctation

MGI Mouse Phenotypes related to Aortic Coarctation:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.2 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
2 growth/size/body region MP:0005378 10.1 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
3 adipose tissue MP:0005375 10.08 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
4 homeostasis/metabolism MP:0005376 10.07 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
5 endocrine/exocrine gland MP:0005379 10.03 ACE ADRB1 ADRB2 CYP11B2 EDN1 FBN1
6 mortality/aging MP:0010768 9.96 ACE ADRB1 AGT AGTR1 EDN1 FBN1
7 immune system MP:0005387 9.92 ACE ADRB2 AGT AGTR1 CYP11B2 FBN1
8 muscle MP:0005369 9.7 ADRB1 ADRB2 AGT EDN1 FBN1 NOS3
9 nervous system MP:0003631 9.61 ADRB2 AGT AGTR1 CYP11B2 EDN1 FBN1
10 renal/urinary system MP:0005367 9.23 ACE AGT AGTR1 CYP11B2 EDN1 FBN1

Drugs & Therapeutics for Aortic Coarctation

Drugs for Aortic Coarctation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 83)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4,Phase 1 38396-39-3, 2180-92-9 2474
2
Sevoflurane Approved, Vet_approved Phase 4,Phase 2 28523-86-6 5206
3
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
4
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
5
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
6
Racepinephrine Approved Phase 4 329-65-7 838
7
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
8
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
9
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
10
Atorvastatin Approved Phase 4 134523-00-5 60823
11 Neurotransmitter Agents Phase 4
12 Peripheral Nervous System Agents Phase 4,Phase 1
13 Central Nervous System Depressants Phase 4,Phase 2,Phase 1
14 Platelet Aggregation Inhibitors Phase 4,Phase 2
15 Analgesics Phase 4,Phase 1
16 Anesthetics, Inhalation Phase 4,Phase 2
17 Anesthetics Phase 4,Phase 2,Phase 1
18 Anesthetics, Local Phase 4,Phase 1
19 Anesthetics, General Phase 4,Phase 2
20 Pharmaceutical Solutions Phase 4,Phase 1
21 Analgesics, Opioid Phase 4,Phase 1
22 Anesthetics, Intravenous Phase 4
23 Excitatory Amino Acids Phase 4
24 Epinephryl borate Phase 4
25 Neuromuscular Nondepolarizing Agents Phase 4
26 Excitatory Amino Acid Antagonists Phase 4
27 Hypnotics and Sedatives Phase 4
28 Anesthetics, Dissociative Phase 4
29 Neuromuscular Agents Phase 4
30 Neuromuscular Blocking Agents Phase 4
31 Adjuvants, Anesthesia Phase 4
32 Narcotics Phase 4
33 Antimetabolites Phase 4
34 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
35 Lipid Regulating Agents Phase 4
36 Hypolipidemic Agents Phase 4
37 Anticholesteremic Agents Phase 4
38
Furosemide Approved, Vet_approved Phase 2 54-31-9 3440
39
Nitric Oxide Approved Phase 2 10102-43-9 145068
40
Nitroprusside Approved, Investigational Phase 2 15078-28-1 11963622
41
Nitroglycerin Approved, Investigational Phase 2 55-63-0 4510
42 Natriuretic Agents Phase 2
43 diuretics Phase 2
44 Sodium Potassium Chloride Symporter Inhibitors Phase 2
45 Antihypertensive Agents Phase 2
46 Vasodilator Agents Phase 2
47 Nitric Oxide Donors Phase 2
48 Hormones Phase 2,Phase 1
49
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
50
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 Paravertebral Nerve Blocks in Neonates Recruiting NCT03408340 Phase 4 Standard of Care Anesthesia
2 Statins and Endothelial Function in Patients With Coarctation of the Aorta Terminated NCT00767572 Phase 4 atorvastatin;Sugar pill
3 Covered CP Stents for the Prevention or Treatment of Aortic Wall Injury Associated With Coarctation of the Aorta Completed NCT01278303 Phase 2
4 Furosemide and Coarctation Surgery Lung Complications Completed NCT03364842 Phase 2 Furosemide
5 Effect of Strategy for Blood Pressure Control on Cerebral Oxygen Balance During Aortic Coarctation Repair: A Randomized Study Completed NCT00535808 Phase 2 nitroprusside;nitroglycerine;sevoflurane
6 Can Oral T3 Normalize Thyroid Hormone Levels Following Cardiopulmonary Bypass in Children? Completed NCT01780584 Phase 2 Oral T3 Low dose;Placebo;Oral T3 high dose
7 The Effect of Paravertebral Block With Dexamethasone on Intraoperative and Postoperative Analgesia in Children Undergoing Surgery for Coarctation of Aorta Completed NCT03074773 Phase 1 Dexamethasone;Bupivacaine
8 Radiation-Free Heart Catheterization Using MRI Recruiting NCT02739087 Phase 1
9 Proof of Concept of Model Based Cardiovascular Prediction Unknown status NCT02591940
10 T1 Mapping of Diffuse Myocardial Fibrosis in Congenital Heart Disease Unknown status NCT02350829 Not Applicable
11 National Congenital Heart Disease Audit Unknown status NCT02303535
12 Coarctation Of the Aorta Stent Trial Completed NCT00552812 Not Applicable
13 Antenatal Diagnosis of Coarctations of the Aorta. Completed NCT03303768
14 Evaluation of Image-Based Modelling on Clinical Decisions in Coarctation of the Aorta Completed NCT02700737 Not Applicable
15 MRI Assessment of RV Function: Patients With TOF or Aortic Coarctation Completed NCT00277901
16 Large Diameter Advanta™ V12 Covered Stent Trial for Coarctation of the Aorta Completed NCT00978952 Not Applicable
17 Evaluation of Vascular Pathology With 3D, Time-Resolved Phase Contrast Magnetic Resonance Imaging (MRI) Completed NCT00722904
18 A Pilot Study of Thrombin Generation Changes in Neonates Undergoing Placement of a Blalock-Taussig Shunt Completed NCT01340378
19 Cerebral Perfusion During Neonatal Cardiac Surgery Completed NCT01032876 Not Applicable
20 Bupropion & Cardio Birth Defect (Slone) Completed NCT01597661 Exposure to any bupropion during the first trimester;Exposure to bupropion alone during the first trimester
21 Longitudinal Study of Neurologic, Cognitive, and Radiologic Outcomes of PHACE Syndrome Completed NCT01018082
22 X-ray Fluoroscopy Fused With Computed Tomography (XFC) Technical Development Completed NCT00965679
23 Study of the Corelation Between Circulating Nuclearsome and SIRS Happened After Congential Cardiac Surgery Completed NCT02325765
24 Reproduction and Survival After Cardiac Defect Repair Completed NCT00005190
25 National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions Completed NCT01322165
26 Clinical Assessment of Perfusion Techniques During Repair of Coarctation With Aortic Arch Hypoplasia in Infants Recruiting NCT02835703 Not Applicable
27 Long-term Outcomes and Vascular Evaluation After Coarctation of the Aorta Treatment Recruiting NCT03262753
28 Haemodynamics and Function of the Atria in Congenital Heart Disease by Cardiovascular Magnetic Resonance Recruiting NCT02161471
29 Cardiovascular Response to Maternal Hyperoxygenation in Fetal Congenital Heart Disease Recruiting NCT03147014 Not Applicable
30 Long Term Results in Hypoplastic Aortic Arch Repair in Neonates Using a Glutaraldehyde Treated Autologous Pericardial Patch Recruiting NCT03588312
31 Genetic Analysis of PHACE Syndrome (Hemangioma With Other Congenital Anomalies) Recruiting NCT01016756
32 Genetic and Phenotypic Characteristics of Mitral Valve Prolapse Recruiting NCT03884426
33 Cardiac Remodeling and Circulating Biomarkers in Pediatric Left Ventricular Pressure Loading Lesions Active, not recruiting NCT02545790
34 Surgical Outcomes in Pediatric Patients With Coarctation and VSD Terminated NCT00327795
35 Aortic Arch Reconstruction Terminated NCT00277940

Search NIH Clinical Center for Aortic Coarctation

Genetic Tests for Aortic Coarctation

Anatomical Context for Aortic Coarctation

MalaCards organs/tissues related to Aortic Coarctation:

42
Heart, Kidney, Spinal Cord, Testes, Endothelial, Brain, Tongue

Publications for Aortic Coarctation

Articles related to Aortic Coarctation:

(show top 50) (show all 3188)
# Title Authors Year
1
Right aortic arch with an aberrant left subclavian artery and aortic coarctation including a descending aortic aneurysm. ( 30940154 )
2019
2
Aortic coarctation repair through left thoracotomy: results in the modern era. ( 30165590 )
2019
3
Treatment of Aortic Coarctation by Self-expanding Thoracic Endograft with Left Subclavian In Situ Laser Fenestration. ( 30342211 )
2019
4
Aortic morphological variability in patients with bicuspid aortic valve and aortic coarctation. ( 30380029 )
2019
5
Patient-specific requirements and clinical validation of MRI-based pressure mapping: A two-center study in patients with aortic coarctation. ( 30390353 )
2019
6
Current Transcatheter Approaches for the Treatment of Aortic Coarctation in Children and Adults. ( 30449421 )
2019
7
Multicenter experience with endovascular treatment of aortic coarctation in adults. ( 30528403 )
2019
8
Predictive factors for residual hypertension following aortic coarctation stenting. ( 30585428 )
2019
9
Native aortic coarctation presenting as prolonged pyrexia in a teenager with 22q11.2 deletion. ( 30636080 )
2019
10
Abnormal blood flow and wall shear stress are present in corrected aortic coarctation despite successful surgical repair. ( 30648829 )
2019
11
Patient-specific non-invasive estimation of pressure gradient across aortic coarctation using magnetic resonance imaging. ( 30709715 )
2019
12
Multiple aneurysms, aortic coarctation, and persistent trigeminal artery. A unique presentation. ( 30775060 )
2019
13
An uncommon case of acute non-traumatic paraplegia: endovascular management of an occluding thrombus in the thoracic aorta 32 years after open surgery for aortic coarctation. ( 30805620 )
2019
14
Endovascular Treatment of Intercostal Artery Aneurysm Associated with Aortic Coarctation. ( 30831105 )
2019
15
Surgical repair of aortic coarctation in pediatric age: A single center two decades experience. ( 30866121 )
2019
16
Percutaneous reintervention in patients with aortic coarctation stenting at an early age. ( 30910769 )
2019
17
A Long-term Survival after Surgical Treatment for Atypical Aortic Coarctation Complicating Takayasu Arteritis with Inactive Disease at the Diagnosis: An Appropriately Treated Autopsy Case. ( 30996177 )
2019
18
First use and limitations of Magmaris® bioresorbable stenting in a low birth weight infant with native aortic coarctation. ( 31001884 )
2019
19
Hemodynamic Changes During Physiological and Pharmacological Stress Testing in Healthy Subjects, Aortic Stenosis and Aortic Coarctation Patients-A Systematic Review and Meta-Analysis. ( 31024935 )
2019
20
Aortic Coarctation/Arch Hypoplasia Repair: How Small Is Too Small. ( 31027557 )
2019
21
Coarctation of the Aorta in Adolescence: Significance of Detailed Cardiac Examination in Pediatric Hypertension. ( 30973498 )
2019
22
Coarctation of the aorta and left ventricular diverticulum in Kabuki syndrome. ( 30746822 )
2019
23
Subclinical Burden of Coronary Artery Calcium in Patients With Coarctation of the Aorta. ( 30424867 )
2019
24
Perioperative and Anesthetic Management of Coarctation of the Aorta. ( 30614372 )
2019
25
The effect of including increased arterial stiffness in the upper body when modelling Coarctation of the Aorta. ( 30714407 )
2019
26
Delayed diagnosis of coarctation of the aorta with marked collateral circulation. ( 30878963 )
2019
27
Management of Coarctation of The Aorta in Adult Patients: State of The Art. ( 30895757 )
2019
28
Long-term mortality and cardiovascular burden for adult survivors of coarctation of the aorta. ( 30923175 )
2019
29
Impact of Treatment Modality on Vascular Function in Coarctation of the Aorta: The LOVE - COARCT Study. ( 30929556 )
2019
30
Improving Prenatal Diagnosis of Coarctation of the Aorta. ( 30935636 )
2019
31
Increased blood pressure is associated with increased carotid artery intima-media thickness in children with repaired coarctation of the aorta. ( 30950974 )
2019
32
Human genotyping and an experimental model reveal NPR-C as a possible contributor to morbidity in coarctation of the aorta. ( 31002586 )
2019
33
Prostaglandin Infusion in Neonate With Severe Coarctation of the Aorta With Closed Ductus Arteriosus-A Case Report and Review of the Literature. ( 31010402 )
2019
34
A case report of mycotic pseudoaneurysm in childhood: an unusual complication of coarctation of the aorta. ( 31020245 )
2019
35
Cardiovascular risk factors in adults with coarctation of the aorta. ( 31099471 )
2019
36
Is balloon angioplasty superior to surgery in the treatment of paediatric native coarctation of the aorta: a systematic review and meta-analysis. ( 30060099 )
2019
37
Primary surgical repair of coarctation of the aorta in adolescents and adults: intermediate results and consequences of hypertension. ( 29933438 )
2019
38
A Cross-Sectional Study of the Prevalence of Exercise-Induced Hypertension in Childhood Following Repair of Coarctation of the Aorta. ( 29691159 )
2019
39
Circulating biomarkers of left ventricular hypertrophy in pediatric coarctation of the aorta. ( 30650250 )
2019
40
A single-stage hybrid approach for the management of severely stenotic bicuspid aortic valve, ascending aortic aneurysm, and coarctation of the aorta with a literature review. ( 30279887 )
2018
41
Case Image: Treatment of aortic coarctation, saccular thoracic aortic aneurysm, and corresponding feeding collateral vessel with a fully percutaneous endovascular approach. ( 29664433 )
2018
42
Successful exclusion of an aortic aneurysm with a novel PTFE-tube covered cobalt-chromium stent in a pediatric patient with native coarctation of the aorta. ( 29726634 )
2018
43
Immediate and midterm results of balloon angioplasty for recurrent aortic coarctation in children aged<1 year. ( 29030063 )
2018
44
Is hypertension the fate of aortic coarctation patients treated with Cheatham Platinum (CP) stent? ( 29164683 )
2018
45
Ascending aortic size in aortic coarctation depends on aortic valve morphology: Understanding the bicuspid valve phenotype. ( 29169748 )
2018
46
Mechanical deformation in adult patients with unrepaired aortic coarctation. ( 29189934 )
2018
47
Aortic coarctation decision making comes of age. ( 29224838 )
2018
48
Complex aortic coarctation and a bicuspid aortic valve with severe stenosis in a 68 year-old woman. ( 29242098 )
2018
49
Finding value in a common medical misnomer: The importance of identifying a bovine arch in patients with aortic coarctation. ( 29248280 )
2018
50
Assessment the effect of dexmedetomidine on incidence of paradoxical hypertension after surgical repair of aortic coarctation in pediatric patients. ( 29336388 )
2018

Variations for Aortic Coarctation

Expression for Aortic Coarctation

Search GEO for disease gene expression data for Aortic Coarctation.

Pathways for Aortic Coarctation

Pathways related to Aortic Coarctation according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 ADRB1 ADRB2 AGT AGTR1 EDN1 GNB3
2
Show member pathways
12.71 ADRB1 ADRB2 AGTR1 CYP11B2
3
Show member pathways
12.59 AGT AGTR1 EDN1 GNB3 NOS3
4
Show member pathways
12.5 ADRB1 ADRB2 AGT EDN1 GNB3
5
Show member pathways
12.47 ADRB1 ADRB2 AGTR1 NOS3
6 12.09 ADRB1 ADRB2 AGT GNB3 NOTCH1
7
Show member pathways
12.01 ACE AGT GNB3
8
Show member pathways
11.92 AGT AGTR1 GNB3
9
Show member pathways
11.91 ADRB1 ADRB2 AGTR1 NOS3
10 11.84 ADRB1 ADRB2 GNB3
11
Show member pathways
11.84 ADRB1 ADRB2 GNB3 GRK4 NOS3
12 11.79 AGTR1 GNB3 NOS3
13 11.74 ADRB1 ADRB2 GNB3
14 11.58 AGTR1 EDN1 NOS3
15 11.12 ADRB2 AGTR1
16 10.97 AGTR1 FBN1
17 10.96 AGT EDN1
18 10.96 ADRB1 EDN1 NOS3
19 10.89 ADRB1 ADRB2
20 10.86 ACE ADRB1 ADRB2 AGT AGTR1

GO Terms for Aortic Coarctation

Biological processes related to Aortic Coarctation according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 in utero embryonic development GO:0001701 9.87 EDN1 NOS3 NOTCH1
2 regulation of cell proliferation GO:0042127 9.86 AGT AGTR1 NOTCH1
3 response to lipopolysaccharide GO:0032496 9.86 EDN1 NOS3 NOTCH1
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.85 AGT AGTR1 EDN1
5 activation of adenylate cyclase activity GO:0007190 9.7 ADRB1 ADRB2
6 homeostasis of number of cells within a tissue GO:0048873 9.7 NOS3 NOTCH1
7 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0051482 9.69 AGTR1 EDN1
8 positive regulation of reactive oxygen species metabolic process GO:2000379 9.69 AGT AGTR1
9 brown fat cell differentiation GO:0050873 9.69 ADRB1 ADRB2
10 positive regulation of cardiac muscle hypertrophy GO:0010613 9.68 AGT EDN1
11 posttranscriptional regulation of gene expression GO:0010608 9.68 ACE MATR3
12 positive regulation of blood pressure GO:0045777 9.67 ACE AGT
13 aortic valve morphogenesis GO:0003180 9.67 NOS3 NOTCH1
14 kidney development GO:0001822 9.67 ACE AGT AGTR1 FBN1
15 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.66 ADRB1 ADRB2
16 cellular response to peptide hormone stimulus GO:0071375 9.66 CYP11B2 EDN1
17 vasodilation GO:0042311 9.65 AGT NOS3
18 regulation of sodium ion transport GO:0002028 9.65 ADRB2 NOS3
19 nitric oxide mediated signal transduction GO:0007263 9.65 AGT NOS3
20 endocardial cushion morphogenesis GO:0003203 9.64 NOS3 NOTCH1
21 positive regulation of cellular protein metabolic process GO:0032270 9.64 AGT AGTR1
22 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.63 AGT AGTR1
23 vasoconstriction GO:0042310 9.63 AGT EDN1
24 blood vessel remodeling GO:0001974 9.63 ACE AGT NOS3
25 low-density lipoprotein particle remodeling GO:0034374 9.62 AGT AGTR1
26 positive regulation of renal sodium excretion GO:0035815 9.62 AGT EDN1
27 pulmonary valve morphogenesis GO:0003184 9.61 NOS3 NOTCH1
28 negative regulation of multicellular organism growth GO:0040015 9.61 ADRB1 ADRB2
29 artery smooth muscle contraction GO:0014824 9.6 AGT EDN1
30 positive regulation of cholesterol esterification GO:0010873 9.58 AGT AGTR1
31 diet induced thermogenesis GO:0002024 9.58 ADRB1 ADRB2
32 negative regulation of biomineral tissue development GO:0070168 9.57 NOS3 NOTCH1
33 positive regulation of NAD(P)H oxidase activity GO:0033864 9.56 AGT AGTR1
34 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.55 EDN1 NOS3
35 regulation of renal sodium excretion GO:0035813 9.54 AGT AGTR1
36 renin-angiotensin regulation of aldosterone production GO:0002018 9.52 AGT AGTR1
37 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0002025 9.51 ADRB1 ADRB2
38 regulation of blood vessel size GO:0050880 9.5 AGT EDN1 NOS3
39 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.49 AGT AGTR1
40 regulation of extracellular matrix assembly GO:1901201 9.48 AGT NOTCH1
41 heat generation GO:0031649 9.43 ADRB1 ADRB2
42 regulation of blood vessel diameter GO:0097746 9.43 ACE ADRB2 AGTR1
43 regulation of renal output by angiotensin GO:0002019 9.4 ACE AGT
44 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.33 ACE AGT AGTR1
45 regulation of vasoconstriction GO:0019229 9.26 ACE AGT AGTR1 EDN1
46 regulation of blood pressure GO:0008217 9.02 ACE AGT EDN1 GNB3 NOS3
47 G protein-coupled receptor signaling pathway GO:0007186 10.07 ADRB1 ADRB2 AGT AGTR1 EDN1 GNB3

Molecular functions related to Aortic Coarctation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.43 AGT EDN1 FBN1
2 adrenergic receptor activity GO:0004935 9.32 ADRB1 ADRB2
3 epinephrine binding GO:0051379 9.16 ADRB1 ADRB2
4 norepinephrine binding GO:0051380 8.96 ADRB1 ADRB2
5 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Aortic Coarctation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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