MCID: ART031
MIFTS: 45

Aortic Coarctation

Categories: Rare diseases

Aliases & Classifications for Aortic Coarctation

MalaCards integrated aliases for Aortic Coarctation:

Name: Aortic Coarctation 53 17
Coarctation of the Aorta 53

Classifications:



External Ids:

Summaries for Aortic Coarctation

MalaCards based summary : Aortic Coarctation, also known as coarctation of the aorta, is related to aortic valve disease 1 and pediatric hypertension. An important gene associated with Aortic Coarctation is TRAF7 (TNF Receptor Associated Factor 7), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Development Angiotensin activation of ERK. The drugs Bupivacaine and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and testes, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 75 Coarctation of the aorta (CoA or CoAo), also called aortic narrowing, is a congenital condition whereby... more...

Related Diseases for Aortic Coarctation

Diseases related to Aortic Coarctation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 447)
# Related Disease Score Top Affiliating Genes
1 aortic valve disease 1 31.1 NOTCH1 FBN1 ACE
2 pediatric hypertension 30.8 AGT ACE
3 fibromuscular dysplasia 30.7 AGTR1 AGT ACE
4 aortic valve insufficiency 30.6 NOTCH1 FBN1 ACE
5 congestive heart failure 30.4 EDN1 AGTR1 ADRB2 ADRB1 ACE
6 postural orthostatic tachycardia syndrome 30.3 FBN1 AGTR1
7 end stage renal failure 30.3 AGTR1 AGT ACE
8 renal hypertension 30.2 EDN1 AGTR1 ACE
9 meningococcal infection 30.0 AGTR1 AGT ADRB2 ADRB1
10 limb ischemia 29.9 NOS3 EDN1 ACE
11 hypertensive heart disease 29.8 CYP11B2 AGTR1 AGT ACE
12 renovascular hypertension 29.8 NOS3 EDN1 AGTR1 ACE
13 malignant hypertension 29.8 EDN1 AGTR1 AGT ACE
14 acute myocardial infarction 29.8 EDN1 AGTR1 ADRB1 ACE
15 ischemia 29.8 NOS3 EDN1 ACE
16 tetralogy of fallot 29.8 NOTCH1 FBN1 EDN1
17 angina pectoris 29.7 NOS3 EDN1 ACE
18 pulmonary edema 29.7 NOS3 EDN1 ACE
19 coronary heart disease 1 29.5 NOS3 ADRB1 ACE
20 sleep apnea 29.4 NOS3 EDN1 ACE
21 pre-eclampsia 29.3 NOS3 EDN1 AGTR1 AGT
22 arteries, anomalies of 29.3 NOS3 EDN1 AGTR1 AGT ACE
23 kidney disease 29.1 NOS3 EDN1 AGTR1 AGT ACE
24 coronary artery anomaly 29.0 NOS3 EDN1 AGTR1 ADRB2 ADRB1 ACE
25 mitral valve disease 28.9 NOS3 FBN1 AGTR1 AGT ACE
26 heart disease 28.5 NOTCH1 NOS3 EDN1 AGTR1 ADRB1 ACE
27 orthostatic intolerance 28.1 NOS3 FBN1 EDN1 AGTR1 ADRB2 ADRB1
28 dilated cardiomyopathy 27.9 NOS3 EDN1 CYP11B2 AGTR1 AGT ADRB2
29 hypertension, essential 26.3 NOS3 GRK4 GNB3 EDN1 CYP11B2 AGTR1
30 cardiac septal defects with coarctation of the aorta 12.7
31 phace syndrome 11.7
32 congenital heart defects, hamartomas of tongue, and polysyndactyly 11.6
33 tricuspid atresia 11.4
34 cardiac, facial, and digital anomalies with developmental delay 11.4
35 heart defect-tongue hamartoma-polysyndactyly syndrome 11.3
36 aneurysm 10.9
37 ventricular septal defect 10.8
38 heart septal defect 10.8
39 patent ductus arteriosus 1 10.8
40 aortic aneurysm 10.7
41 coarctation of aorta 10.7
42 paraplegia 10.6
43 resting heart rate, variation in 10.5 ADRB2 ADRB1
44 ocular hypotension 10.5 ADRB2 ADRB1
45 hypoaldosteronism 10.5 CYP11B2 ACE
46 cardiac arrest 10.5
47 aortic arch interruption 10.5
48 endocarditis 10.4
49 pulmonary hypertension 10.4
50 perinephritis 10.4 EDN1 ADRB2

Graphical network of the top 20 diseases related to Aortic Coarctation:



Diseases related to Aortic Coarctation

Symptoms & Phenotypes for Aortic Coarctation

MGI Mouse Phenotypes related to Aortic Coarctation:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.17 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
2 growth/size/body region MP:0005378 10.07 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
3 adipose tissue MP:0005375 10.06 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
4 homeostasis/metabolism MP:0005376 10.02 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
5 endocrine/exocrine gland MP:0005379 10.01 ACE ADRB1 ADRB2 CYP11B2 EDN1 FBN1
6 mortality/aging MP:0010768 9.96 ACE ADRB1 AGT AGTR1 EDN1 FBN1
7 muscle MP:0005369 9.7 ADRB1 ADRB2 AGT EDN1 FBN1 NOS3
8 nervous system MP:0003631 9.61 ADRB2 AGT AGTR1 CYP11B2 EDN1 FBN1
9 renal/urinary system MP:0005367 9.23 ACE AGT AGTR1 CYP11B2 EDN1 FBN1

Drugs & Therapeutics for Aortic Coarctation

Drugs for Aortic Coarctation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 100)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
3
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
4
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
5
Racepinephrine Approved Phase 4 329-65-7 838
6
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
7
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
8
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
9
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
10
Atorvastatin Approved Phase 4 134523-00-5 60823
11 Anesthetics, Local Phase 4
12 Pharmaceutical Solutions Phase 4
13 Analgesics Phase 4
14 Analgesics, Opioid Phase 4
15 Anesthetics Phase 4
16 Central Nervous System Depressants Phase 4
17 Peripheral Nervous System Agents Phase 4
18 Neurotransmitter Agents Phase 4
19 Neuromuscular Nondepolarizing Agents Phase 4
20 Narcotics Phase 4
21 Neuromuscular Agents Phase 4
22 Adjuvants, Anesthesia Phase 4
23 Neuromuscular Blocking Agents Phase 4
24 Epinephryl borate Phase 4
25 Hypnotics and Sedatives Phase 4
26 Platelet Aggregation Inhibitors Phase 4
27 Anesthetics, General Phase 4
28 Excitatory Amino Acid Antagonists Phase 4
29 Anesthetics, Dissociative Phase 4
30 Anesthetics, Inhalation Phase 4
31 Anesthetics, Intravenous Phase 4
32 Excitatory Amino Acids Phase 4
33 Lipid Regulating Agents Phase 4
34 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
35 Hypolipidemic Agents Phase 4
36 Antimetabolites Phase 4
37 Anticholesteremic Agents Phase 4
38
Furosemide Approved, Vet_approved Phase 2 54-31-9 3440
39
Nitroprusside Approved, Investigational Phase 2 15078-28-1 11963622
40
Nitric Oxide Approved Phase 2 10102-43-9 145068
41
Nitroglycerin Approved, Investigational Phase 2 55-63-0 4510
42 diuretics Phase 2
43 Sodium Potassium Chloride Symporter Inhibitors Phase 2
44 Natriuretic Agents Phase 2
45 Antihypertensive Agents Phase 2
46 Nitric Oxide Donors Phase 2
47 Vasodilator Agents Phase 2
48
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
49
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
50 Gastrointestinal Agents Phase 1

Interventional clinical trials:

(show all 41)
# Name Status NCT ID Phase Drugs
1 Paravertebral Nerve Blocks in Neonates and Infants Undergoing Repair of Aortic Coarctation, A Pilot Study Recruiting NCT03408340 Phase 4 Standard of Care Anesthesia
2 Effects of Statins on Endothelial Function in Patients With Coarctation of the Aorta Terminated NCT00767572 Phase 4 atorvastatin;Sugar pill
3 Covered Cheatham Platinum Stents for the Prevention or Treatment of Aortic Wall Injury Associated With Coarctation of the Aorta Completed NCT01278303 Phase 2
4 Furosemide: Would it Help to Improve the Lungs During Aortic Coarctation Surgery Completed NCT03364842 Phase 2 Furosemide
5 Effect of Strategy for Blood Pressure Control on Cerebral Oxygen Balance During Aortic Coarctation Repair: a Randomized Study Completed NCT00535808 Phase 2 nitroprusside;nitroglycerine;sevoflurane
6 Paravertebral Block in Coarctation of the Aorta Completed NCT03074773 Phase 1 Dexamethasone;Bupivacaine
7 Real-Time MRI-Guided Percutaneous Intervention for Aorto-illac and Femoropopliteal, Artery Stenosis Completed NCT00094783 Phase 1
8 Radiation-Free Heart Catheterization Using MRI Recruiting NCT02739087 Phase 1
9 LOVE-COARCT Study: Long-term Outcomes and Vascular Evaluation After Coarctation of the Aorta Treatment Unknown status NCT03262753
10 Proof of Concept of Model Based Cardiovascular Prediction Unknown status NCT02591940
11 The Prevalence and the Prognosis of Resistant Hypertension Ascertained With Systemic Investigation and Optimal Treatment With Antihypertensive Drugs Unknown status NCT01703780
12 Large Diameter Advanta™ V12 Covered Stent Trial for Coarctation of the Aorta Completed NCT00978952
13 Antenatal Diagnosis of Coarctations of the Aorta. Prospective Observational Study. Completed NCT03303768
14 Coarctation Of the Aorta Stent Trial Completed NCT00552812
15 Evaluation of Image-Based Modelling on Clinical Decisions in Coarctation of the Aorta Completed NCT02700737
16 Reproduction and Survival After Cardiac Defect Repair Completed NCT00005190
17 Carotid Atherosclerosis in Patients With Aortic Coarctation Completed NCT03999073
18 A Pilot Study of Thrombin Generation Changes in Neonates Undergoing Placement of a Blalock-Taussig Shunt Completed NCT01340378
19 Evaluation of Vascular Pathology With 3D, Time-Resolved Phase Contrast MRI Completed NCT00722904
20 MRI Assessment of Two Congenital Heart Disease States: Assessment of Right Ventricular Function: Predictor of Optimal Timing of Pulmonary Valve Replacement in Patients With TOF; Assessment of Flow Dynamics in Patients With Aortic Coarctation Completed NCT00277901
21 Bupropion and Cardiac Birth Defects (Slone Epidemiology Center) Completed NCT01597661 Exposure to any bupropion during the first trimester;Exposure to bupropion alone during the first trimester
22 SPY Imaging System: Its Role in Pediatric Cardiac Surgery Completed NCT00446927
23 Balloon Valvuloplasty Registry Completed NCT00005199
24 Randomized Controlled Trial on Deep Hypothermic Circulatory Arrest Versus Antegrade Cerebral Perfusion During Neonatal Cardiac Surgery Completed NCT01032876
25 Hemangioma Associated With High Rates of Morbidity:A Prospective Study Completed NCT00394888
26 Longitudinal Study of Neurologic, Cognitive, and Radiologic Outcomes in PHACE Syndrome Completed NCT01018082
27 Evaluation of a Modified Perfusion Strategy for Neonatal Aortic Arch Reconstruction: Does Perfusing the Lower Body During Arch Repair Help? Completed NCT00490256
28 Evaluation of an Oral Health Intervention Program for Children With Congenital Heart Defects Completed NCT03311438
29 Hemodynamic Assessment With Trans-esophageal Doppler (TED) During Prone Ventilation in Patients With Acute Respiratory Distress Syndrome (ARDS) Completed NCT02664090
30 Cardiovascular Response to Maternal Hyperoxygenation in Fetal Congenital Heart Disease Recruiting NCT03147014
31 Prognosis and Integrative Assessment of Aortic Coarctation Patients in CHINA Recruiting NCT04011956
32 Clinical Assessment of Perfusion Techniques During Surgical Repair of Coarctation of Aorta With Aortic Arch Hypoplasia in Infants Recruiting NCT02835703
33 Retrospective Analysis of Results in Children Treated by an Autologous Pericardial Patch to Repair a Hypoplastic Aortic Arch Associated to Other Congenital Heart Defects Recruiting NCT03588312
34 Evaluation of Aortic Stiffness as a Prognostic Indicator of Aortic Dilatation in Patients With Bicuspid Aortic Valve (BAV) by Multimodal Imaging (MRI, Echocardiography and Ultrafast Ultrasound Imaging) Recruiting NCT03474159
35 Haemodynamics and Function of the Atria in Patients With Congenital Heart Defects - Pilot Study by Cardiovascular Magnetic Resonance Active, not recruiting NCT02161471
36 Serum Androgen Levels as a Marker for the Severity of Preeclampsia Active, not recruiting NCT03744988
37 Cardiac Remodeling and Circulating Biomarkers in Pediatric Left Ventricular Pressure Loading Lesions Active, not recruiting NCT02545790
38 Cardiac Catheterization in the Management of Pediatric Cardiac Patients at Assiut University Children Hospital ( A Descriptive Study) Not yet recruiting NCT03398187
39 Staged Approach to Coarctation and VSD Can Offer Optimal Outcomes Terminated NCT00327795
40 Neoaortic Elastic Properties After Aortic Arch Reconstruction Terminated NCT00277940
41 Incidence of Infection in the Patient With DiGeorge Syndrome Following Surgery for Congenital Heart Disease Terminated NCT00278005

Search NIH Clinical Center for Aortic Coarctation

Genetic Tests for Aortic Coarctation

Anatomical Context for Aortic Coarctation

MalaCards organs/tissues related to Aortic Coarctation:

41
Heart, Kidney, Testes, Brain, Endothelial, Lung, Spinal Cord

Publications for Aortic Coarctation

Articles related to Aortic Coarctation:

(show top 50) (show all 6927)
# Title Authors PMID Year
1
Exercise Capacity in Asymptomatic Adult Patients Treated for Coarctation of the Aorta. 38
31392380 2019
2
Long-term mortality and cardiovascular burden for adult survivors of coarctation of the aorta. 38
30923175 2019
3
Increased blood pressure is associated with increased carotid artery intima-media thickness in children with repaired coarctation of the aorta. 38
30950974 2019
4
Comparison Between Nomograms Used to Define Pediatric Aortic Arch Hypoplasia: Retrospective Evaluation Among Patients Less Than 1 Year Old with Coarctation of the Aorta. 38
31165902 2019
5
Aortic recoarctation and pseudoaneurysm five decades after repair. 38
31421653 2019
6
A Long-term Survival after Surgical Treatment for Atypical Aortic Coarctation Complicating Takayasu Arteritis with Inactive Disease at the Diagnosis: An Appropriately Treated Autopsy Case. 38
30996177 2019
7
Emergency Pulmonary Artery-to-Systemic Artery Shunt to Break the Positive Feedback Loop of a Pulmonary Hypertensive Crisis after Neonatal Coarctation Repair. 38
31403029 2019
8
Metabolic Syndrome in Adult Congenital Heart Disease. 38
31347322 2019
9
Fetal Echocardiographic Parameters and Surgical Outcomes in Congenital Left-Sided Cardiac Lesions. 38
31338561 2019
10
Multiple Unusual Vascular Anomalies Accompanying Aortic Coarctation. 38
31420185 2019
11
Left ventricular non-compaction in a child with bicuspid aortic valve and aortic coarctation. 38
31379312 2019
12
Coarctation of Aorta Presenting as Spontaneous Subarachnoid Hemorrhage in a Young Female: A Case Report of a Rare Clinical Entity. 38
31413782 2019
13
Utility of 3D Printed Cardiac Models for Medical Student Education in Congenital Heart Disease: Across a Spectrum of Disease Severity. 38
31240370 2019
14
A single centre experience with an evolving approach for the repair of coarctation of the aorta. 38
31296278 2019
15
Arterial hypertension and endovascular treatment of adults with coarctation of the aorta: a single-center experience. 38
31364609 2019
16
Induction of LOX by TGF-β1/Smad/AP-1 signaling aggravates rat myocardial fibrosis and heart failure. 38
31317653 2019
17
Evaluation of 4D flow MRI-based non-invasive pressure assessment in aortic coarctations. 38
31326119 2019
18
Cardiovascular risk factors in adults with coarctation of the aorta. 38
31099471 2019
19
Proximal Arch in Left Thoracotomy Repair of Neonatal and Infant Coarctation-How Small Is Too Small? 38
31307310 2019
20
Small Supernumerary Ring Chromosome Derived from an Inverted Duplication of 13q11.2q14 in a Fetus with Coarctation of the Aorta. 38
31315112 2019
21
Be Aware of Aberrant Right Subclavian Artery Origin Before Aortic Coarctation Stenting: A Case Report Study. 38
31309863 2019
22
Major Device-Dependence of Measured Hypertensive Status From 24-Hour Ambulatory Blood Pressure Monitoring After Aortic Coarctation Repair. 38
30931916 2019
23
The Challenges of Redo Aortic Coarctation Repair in Adults. 38
31352579 2019
24
Correction: Diagnosis, imaging and clinical management of aortic coarctation. 38
31243116 2019
25
Endovascular Treatment of Intercostal Artery Aneurysm Associated With Aortic Coarctation. 38
30831105 2019
26
Too simple to be true: aortic coarctation repair. 38
31274155 2019
27
Medium-term systemic blood pressure after stenting of aortic coarctation: a systematic review and meta-analysis. 38
31315937 2019
28
Furosemide: Would it help to improve the lungs as evaluated by sonography and compliance during aortic coarctation surgery. 38
31274485 2019
29
Hypertension in patients with repaired aortic coarctation: the long and puzzling road from Morgagni to stent implantation. 38
31315938 2019
30
Secondary Hypertension and Complications: Diagnosis and Role of Imaging. 38
31173541 2019
31
Rare diseases in China: analysis of 2014-2015 hospitalization summary reports for 281 rare diseases from 96 tertiary hospitals. 38
31262329 2019
32
Confirmation of the role of pathogenic SMAD6 variants in bicuspid aortic valve-related aortopathy. 38
30796334 2019
33
Perioperative and Anesthetic Management of Coarctation of the Aorta. 38
30614372 2019
34
Coarctation of the aorta. 38
31136401 2019
35
Crim1 suppresses left ventricular hypertrophy. 38
31258903 2019
36
Effective Delivery of Hypertrophic miRNA Inhibitor by Cholesterol-Containing Nanocarriers for Preventing Pressure Overload Induced Cardiac Hypertrophy. 38
31179215 2019
37
Human genotyping and an experimental model reveal NPR-C as a possible contributor to morbidity in coarctation of the aorta. 38
31002586 2019
38
Suitability of lattice Boltzmann inlet and outlet boundary conditions for simulating flow in image-derived vasculature. 38
30838793 2019
39
Surgical repair of graft aneurysm following ascending-to-abdominal aortic bypass. 38
31193596 2019
40
Computational fluid dynamics simulations as a complementary study for transcatheter endovascular stent implantation for re-coarctation of the aorta associated with minimal pressure drop: an aneurysmal ductal ampulla with aortic isthmus narrowing. 38
31198121 2019
41
Foetal right atrial aneurysm and aortic coarctation with left ventricular dysfunction. 38
31221232 2019
42
Persistent stapedial artery in PHACE syndrome. 38
30876851 2019
43
Norwood Operation of a Neonate with Pentalogy of Cantrell. 38
31238028 2019
44
First use and limitations of Magmaris® bioresorbable stenting in a low birth weight infant with native aortic coarctation. 38
31001884 2019
45
Left arm structure and function late after subclavian flap repair of aortic coarctation in childhood. 38
31218968 2019
46
Native aortic coarctation presenting as prolonged pyrexia in a teenager with 22q11.2 deletion. 38
30636080 2019
47
Infective Endarteritis and Mycotic Pseudoaneurysms in a Pediatric Patient With Aortic Coarctation. 38
31151720 2019
48
Patient-specific non-invasive estimation of pressure gradient across aortic coarctation using magnetic resonance imaging. 38
30709715 2019
49
The effects of age at correction of aortic coarctation and recurrent obstruction on adolescent patients: MRI evaluation of wall shear stress and pulse wave velocity. 38
31222473 2019
50
Long-Term Outcomes in Patients With Turner Syndrome: A 68-Year Follow-Up. 38
31131660 2019

Variations for Aortic Coarctation

Expression for Aortic Coarctation

Search GEO for disease gene expression data for Aortic Coarctation.

Pathways for Aortic Coarctation

Pathways related to Aortic Coarctation according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.63 CYP11B2 AGTR1 ADRB2 ADRB1
2
Show member pathways
12.59 NOS3 GNB3 EDN1 AGTR1 AGT
3
Show member pathways
12.5 GNB3 EDN1 AGT ADRB2 ADRB1
4 12.09 NOTCH1 GNB3 AGT ADRB2 ADRB1
5
Show member pathways
12 GNB3 AGT ACE
6
Show member pathways
11.92 NOS3 AGTR1 ADRB2 ADRB1
7
Show member pathways
11.9 GNB3 AGTR1 AGT
8 11.84 GNB3 ADRB2 ADRB1
9
Show member pathways
11.84 NOS3 GRK4 GNB3 ADRB2 ADRB1
10 11.79 NOS3 GNB3 AGTR1
11 11.74 GNB3 ADRB2 ADRB1
12 11.58 NOS3 EDN1 AGTR1
13 10.96 NOS3 EDN1 ADRB1
14 10.95 EDN1 AGT
15 10.93 FBN1 AGTR1
16 10.87 ADRB2 ADRB1
17 10.86 AGTR1 AGT ADRB2 ADRB1 ACE

GO Terms for Aortic Coarctation

Biological processes related to Aortic Coarctation according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.86 NOTCH1 AGTR1 AGT
2 response to lipopolysaccharide GO:0032496 9.86 NOTCH1 NOS3 EDN1
3 positive regulation of cytosolic calcium ion concentration GO:0007204 9.85 EDN1 AGTR1 AGT
4 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0051482 9.7 EDN1 AGTR1
5 homeostasis of number of cells within a tissue GO:0048873 9.69 NOTCH1 NOS3
6 positive regulation of reactive oxygen species metabolic process GO:2000379 9.69 AGTR1 AGT
7 brown fat cell differentiation GO:0050873 9.68 ADRB2 ADRB1
8 posttranscriptional regulation of gene expression GO:0010608 9.68 MATR3 ACE
9 positive regulation of cardiac muscle hypertrophy GO:0010613 9.68 EDN1 AGT
10 positive regulation of blood pressure GO:0045777 9.67 AGT ACE
11 aortic valve morphogenesis GO:0003180 9.67 NOTCH1 NOS3
12 kidney development GO:0001822 9.67 FBN1 AGTR1 AGT ACE
13 vasodilation GO:0042311 9.66 NOS3 AGT
14 cellular response to peptide hormone stimulus GO:0071375 9.66 EDN1 CYP11B2
15 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.65 ADRB2 ADRB1
16 regulation of sodium ion transport GO:0002028 9.65 NOS3 ADRB2
17 nitric oxide mediated signal transduction GO:0007263 9.65 NOS3 AGT
18 vasoconstriction GO:0042310 9.64 EDN1 AGT
19 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.64 AGTR1 AGT
20 positive regulation of cellular protein metabolic process GO:0032270 9.63 AGTR1 AGT
21 endocardial cushion morphogenesis GO:0003203 9.63 NOTCH1 NOS3
22 blood vessel remodeling GO:0001974 9.63 NOS3 AGT ACE
23 pulmonary valve morphogenesis GO:0003184 9.62 NOTCH1 NOS3
24 positive regulation of renal sodium excretion GO:0035815 9.62 EDN1 AGT
25 low-density lipoprotein particle remodeling GO:0034374 9.61 AGTR1 AGT
26 negative regulation of multicellular organism growth GO:0040015 9.61 ADRB2 ADRB1
27 artery smooth muscle contraction GO:0014824 9.59 EDN1 AGT
28 positive regulation of cholesterol esterification GO:0010873 9.58 AGTR1 AGT
29 diet induced thermogenesis GO:0002024 9.58 ADRB2 ADRB1
30 positive regulation of NAD(P)H oxidase activity GO:0033864 9.57 AGTR1 AGT
31 negative regulation of biomineral tissue development GO:0070168 9.56 NOTCH1 NOS3
32 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.55 NOS3 EDN1
33 renin-angiotensin regulation of aldosterone production GO:0002018 9.54 AGTR1 AGT
34 regulation of renal sodium excretion GO:0035813 9.52 AGTR1 AGT
35 regulation of extracellular matrix assembly GO:1901201 9.51 NOTCH1 AGT
36 regulation of blood vessel size GO:0050880 9.5 NOS3 EDN1 AGT
37 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.49 AGTR1 AGT
38 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0002025 9.48 ADRB2 ADRB1
39 regulation of renal output by angiotensin GO:0002019 9.43 AGT ACE
40 regulation of blood vessel diameter GO:0097746 9.43 AGTR1 ADRB2 ACE
41 heat generation GO:0031649 9.4 ADRB2 ADRB1
42 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.33 AGTR1 AGT ACE
43 regulation of vasoconstriction GO:0019229 9.26 EDN1 AGTR1 AGT ACE
44 regulation of blood pressure GO:0008217 9.02 NOS3 GNB3 EDN1 AGT ACE
45 G protein-coupled receptor signaling pathway GO:0007186 10.08 GNB3 EDN1 AGTR1 AGT ADRB2 ADRB1

Molecular functions related to Aortic Coarctation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.43 FBN1 EDN1 AGT
2 adrenergic receptor activity GO:0004935 9.32 ADRB2 ADRB1
3 epinephrine binding GO:0051379 9.16 ADRB2 ADRB1
4 norepinephrine binding GO:0051380 8.96 ADRB2 ADRB1
5 bradykinin receptor binding GO:0031711 8.62 AGTR1 ACE

Sources for Aortic Coarctation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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