MCID: ART017
MIFTS: 56

Aortic Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Aortic Disease

MalaCards integrated aliases for Aortic Disease:

Name: Aortic Disease 12 15
Aortic Diseases 55 44 73
Disorder of the Aorta 12
Aortic Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:520
MeSH 44 D001018
NCIt 50 C101253
SNOMED-CT 68 47040006
ICD10 33 I35.9
UMLS 73 C0003493

Summaries for Aortic Disease

Disease Ontology : 12 An artery disease that is characterized by degeneration of the cells composing the aortic wall.

MalaCards based summary : Aortic Disease, also known as aortic diseases, is related to marfan syndrome and apnea, obstructive sleep. An important gene associated with Aortic Disease is ACTA2 (Actin, Alpha 2, Smooth Muscle, Aorta), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Acetazolamide and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Aortic Disease

Diseases related to Aortic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
# Related Disease Score Top Affiliating Genes
1 marfan syndrome 29.7 ACTA2 ELN FBN1 MMP2 TGFBR1 TGFBR2
2 apnea, obstructive sleep 29.7 CRP IL6 REN
3 loeys-dietz syndrome 29.5 ACTA2 FBN1 TGFB2 TGFBR1 TGFBR2
4 aneurysm 29.5 ACTA2 ELN FBN1 PRKG1 TGFB2 TGFBR1
5 aortic aneurysm 29.4 ACTA2 EFEMP2 ELN FBN1 NOTCH1 PRKG1
6 takayasu arteritis 29.1 CRP IL6 MMP9
7 sleep apnea 28.8 APOE CRP IL6 REN
8 coronary artery anomaly 28.1 APOE CRP IL6 MMP9
9 arteries, anomalies of 27.7 AAAS APOE CRP IL6 MMP9 REN
10 heart disease 27.5 APOE CRP ELN FBN1 IL6 NOTCH1
11 inguinal hernia 27.2 ELN FBN1 IL6 MMP2 MMP9 TIMP1
12 aortic aneurysm, familial abdominal, 1 24.7 AAAS APOE CRP ELN FBN1 IL6
13 heritable thoracic aortic disease 12.0
14 calcific aortic disease with immunologic abnormalities, familial 11.8
15 pseudoxanthoma elasticum-like papillary dermal elastolysis 10.9 ELN FBN1
16 late-onset focal dermal elastosis 10.9 ELN FBN1
17 familial abdominal aortic aneurysm 10.9 ELN FBN1
18 aortic aneurysm, familial thoracic 2 10.9 ACTA2 FBN1
19 loeys-dietz syndrome 1 10.8 TGFBR1 TGFBR2
20 transient hypogammaglobulinemia of infancy 10.8 TGFBR1 TGFBR2
21 char syndrome 10.8 ACTA2 FBN1 TGFBR2
22 familial thoracic aortic aneurysm and dissection 10.8 FBN1 TGFBR1 TGFBR2
23 acute adrenal insufficiency 10.7 IL6 REN
24 aorta atresia 10.7
25 aortic valve insufficiency 10.6 ELN FBN1 NOTCH1
26 transient hypogammaglobulinemia 10.5 TGFBR1 TGFBR2
27 chronic actinic dermatitis 10.5 ELN FBN1 MMP9
28 cold agglutinin disease 10.5 CRP IL6
29 supravalvular aortic stenosis 10.4 ELN FBN1 MMP2
30 connective tissue disease 10.4 ACTA2 ELN FBN1 IL6
31 extracranial arteriovenous malformation 10.4 MMP2 MMP9
32 focal myositis 10.4 MMP2 MMP9
33 exfoliation syndrome 10.3 APOE ELN FBN1
34 spastic entropion 10.3 MMP2 MMP9
35 lentigo maligna melanoma 10.3 MMP2 MMP9
36 bone cancer 10.3 IL6 MMP9 NOTCH1
37 pyomyositis 10.2 CRP NOTCH1
38 pericardial effusion 10.2 CRP IL6 REN
39 senile ectropion 10.2 ELN MMP2 MMP9
40 villous adenocarcinoma 10.2 MMP2 MMP9
41 arterial tortuosity syndrome 10.2 EFEMP2 ELN TGFBR1
42 acute transverse myelitis 10.2 IL6 MMP2 MMP9
43 transverse myelitis 10.2 IL6 MMP2 MMP9
44 psammomatous meningioma 10.2 MMP2 MMP9
45 glucose metabolism disease 10.1 CRP IL6 REN
46 urinary system disease 10.1 CRP IL6 REN
47 cryopyrin-associated periodic syndrome 10.1 CRP IL6
48 acquired metabolic disease 10.1 CRP IL6 REN
49 chorioamnionitis 10.0 CRP IL6 MMP9
50 bacterial meningitis 10.0 CRP IL6 MMP9

Graphical network of the top 20 diseases related to Aortic Disease:



Diseases related to Aortic Disease

Symptoms & Phenotypes for Aortic Disease

GenomeRNAi Phenotypes related to Aortic Disease according to GeneCards Suite gene sharing:

26 (show all 47)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.16 EFEMP2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.16 SMAD4 EFEMP2 MMP2 TGFB2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.16 SMAD4 TGFB2 TGFBR1 TGFBR2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.16 MMP2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.16 TGFB2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.16 TGFBR2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.16 CRP NOTCH1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.16 TGFBR2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.16 MMP2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.16 TGFBR2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.16 TGFBR2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-133 10.16 TGFB2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10.16 TGFB2 NOTCH1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.16 CRP NOTCH1 TGFBR1 TGFBR2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.16 EFEMP2 TGFBR2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.16 EFEMP2 NOTCH1 CRP
17 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.16 TGFBR2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.16 TGFBR2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.16 TGFBR1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.16 TGFBR2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-188 10.16 TGFBR2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-195 10.16 SMAD4
23 Increased shRNA abundance (Z-score > 2) GR00366-A-196 10.16 TGFB2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.16 MMP2
25 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10.16 NOTCH1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.16 SMAD4
27 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.16 NOTCH1 TGFBR2
28 Increased shRNA abundance (Z-score > 2) GR00366-A-215 10.16 TGFB2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.16 SMAD4
30 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.16 EFEMP2
31 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.16 TGFBR1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-37 10.16 TGFBR1
33 Increased shRNA abundance (Z-score > 2) GR00366-A-39 10.16 TGFBR2
34 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.16 SMAD4 TGFB2
35 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.16 SMAD4
36 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.16 SMAD4
37 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.16 CRP
38 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.16 TGFB2
39 Increased shRNA abundance (Z-score > 2) GR00366-A-54 10.16 SMAD4
40 Increased shRNA abundance (Z-score > 2) GR00366-A-6 10.16 NOTCH1
41 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.16 MMP2 CRP
42 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.16 TGFBR2
43 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.16 TGFB2 NOTCH1 SMAD4 TGFBR2
44 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.16 SMAD4
45 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.16 SMAD4 MMP2 TGFBR2
46 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.16 TGFBR1
47 Increased shRNA abundance (Z-score > 2) GR00366-A-88 10.16 TGFBR1

MGI Mouse Phenotypes related to Aortic Disease:

46 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.49 CRP ACTA2 EFEMP2 APOE FBN1 IL6
2 homeostasis/metabolism MP:0005376 10.44 CRP ADAMTS1 APOE FBN1 AAAS MMP2
3 growth/size/body region MP:0005378 10.4 AAAS ADAMTS1 APOE MMP2 IL6 MMP9
4 immune system MP:0005387 10.37 CRP APOE FBN1 MMP2 IL6 MMP9
5 cellular MP:0005384 10.36 APOE AAAS EFEMP2 FBN1 IL6 PRKG1
6 hematopoietic system MP:0005397 10.36 APOE MMP2 IL6 MMP9 FBN1 REN
7 mortality/aging MP:0010768 10.35 ADAMTS1 EFEMP2 APOE MMP2 IL6 MMP9
8 endocrine/exocrine gland MP:0005379 10.31 AAAS ADAMTS1 APOE FBN1 IL6 NOTCH1
9 muscle MP:0005369 10.3 ACTA2 EFEMP2 APOE FBN1 IL6 MMP9
10 digestive/alimentary MP:0005381 10.27 APOE AAAS IL6 MMP9 NOTCH1 SMAD4
11 nervous system MP:0003631 10.22 AAAS APOE FBN1 MMP2 IL6 MMP9
12 integument MP:0010771 10.11 APOE EFEMP2 FBN1 IL6 MMP9 NOTCH1
13 adipose tissue MP:0005375 10.08 APOE ADAMTS1 FBN1 IL6 PRKG1 TGFBR2
14 limbs/digits/tail MP:0005371 10.04 APOE EFEMP2 FBN1 MMP9 SMAD4 TGFB2
15 neoplasm MP:0002006 10.03 MMP2 IL6 MMP9 NOTCH1 TGFBR1 TGFBR2
16 renal/urinary system MP:0005367 10.02 ADAMTS1 APOE FBN1 IL6 MMP9 NOTCH1
17 reproductive system MP:0005389 10 AAAS ADAMTS1 APOE FBN1 IL6 MMP9
18 normal MP:0002873 9.97 EFEMP2 MMP2 PRKG1 REN NOTCH1 SMAD4
19 respiratory system MP:0005388 9.9 EFEMP2 APOE FBN1 MMP2 IL6 MMP9
20 skeleton MP:0005390 9.73 EFEMP2 APOE FBN1 MMP2 IL6 MMP9
21 vision/eye MP:0005391 9.28 APOE ACTA2 EFEMP2 MMP2 IL6 NOTCH1

Drugs & Therapeutics for Aortic Disease

Drugs for Aortic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 225)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
2
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
3
Prednisolone Approved, Vet_approved Phase 4,Not Applicable 50-24-8 5755
4
Atenolol Approved Phase 4 29122-68-7 2249
5
Angiotensin II Approved, Investigational Phase 4,Not Applicable 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
6
Methylprednisolone Approved, Vet_approved Phase 4,Not Applicable 83-43-2 6741
7
Remifentanil Approved Phase 4 132875-61-7 60815
8
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
9
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
10
Iodine Approved, Investigational Phase 4,Not Applicable 7553-56-2 807
11
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
12
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
13
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
14
Eplerenone Approved Phase 4 107724-20-9 150310 443872
15
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
16
Clevidipine Approved, Investigational Phase 4,Not Applicable 167221-71-8
17
Histidine Approved, Nutraceutical Phase 4 71-00-1 6274
18 Prednisolone acetate Phase 4,Not Applicable
19 diuretics Phase 4,Not Applicable
20 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable
21 Methylprednisolone acetate Phase 4,Not Applicable
22 Methylprednisolone Hemisuccinate Phase 4,Not Applicable
23 Adrenergic Agents Phase 4,Phase 1,Early Phase 1
24 Adrenergic Antagonists Phase 4,Phase 1,Early Phase 1
25 Adrenergic beta-1 Receptor Antagonists Phase 4,Early Phase 1
26 Adrenergic beta-Antagonists Phase 4,Not Applicable,Early Phase 1
27 Natriuretic Agents Phase 4,Not Applicable
28 Sympatholytics Phase 4,Early Phase 1
29 Neurotransmitter Agents Phase 4,Phase 2,Phase 1,Early Phase 1
30 Anesthetics Phase 4,Phase 3,Phase 1,Not Applicable
31 Hormone Antagonists Phase 4,Phase 3,Not Applicable
32 Hormones Phase 4,Phase 3,Not Applicable
33 Angiotensin II Type 1 Receptor Blockers Phase 4,Not Applicable
34 Angiotensin Receptor Antagonists Phase 4,Not Applicable
35 Angiotensinogen Phase 4,Not Applicable
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Not Applicable
37 Anti-Arrhythmia Agents Phase 4,Not Applicable
38 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
39 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
40 Anticonvulsants Phase 4
41 Prednisolone hemisuccinate Phase 4,Not Applicable
42 Prednisolone phosphate Phase 4,Not Applicable
43 Autonomic Agents Phase 4,Not Applicable,Early Phase 1
44 Carbonic Anhydrase Inhibitors Phase 4
45 cadexomer iodine Phase 4,Not Applicable
46 Atorvastatin Calcium Phase 4,Phase 3,Not Applicable 134523-03-8
47 Analgesics Phase 4,Phase 2,Phase 3
48 calcium channel blockers Phase 4,Phase 2,Not Applicable
49 Narcotics Phase 4,Phase 3
50 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 527)
# Name Status NCT ID Phase Drugs
1 Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial) Unknown status NCT01904981 Phase 4 Beta-blocker-Atenolol 50mg, PO(peroral), Once daily;Angiotensin receptor blocker-Valsartan 80mg, PO(peroral), Once daily
2 Prophylactic Mesh Implantation After Abdominal Aortic Aneurysm Repair Unknown status NCT01353443 Phase 4
3 ESOS (Endoscopic Saphenous Harvesting With an Open CO2 System) Trial Unknown status NCT01121341 Phase 4
4 Effectiveness of Acetazolamide in Reducing Paralysis of the Leg in Patients Undergoing Aortic Aneurysm Surgery Surgery Unknown status NCT01889498 Phase 4 Acetazolamide
5 Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
6 Effect of Anesthetics on CD39 and CD73 After Open-heart Surgery Completed NCT02136979 Phase 4 Propofol;Sevoflurane
7 Opioid-potentiated Volative Anaesthetic Vs. Remifentanil And Propofol During Abdominal Aortic Aneurysm Surgery Completed NCT00538421 Phase 4 Propofol;Sevoflurane
8 A Multicenter Study of Iomeron®-400 Used With Multi-detector Computed Tomography Angiography (MDCTA) Completed NCT02596048 Phase 4
9 CUstodiol Versus RInger: whaT Is the Best Agent? Completed NCT02327611 Phase 4 Custodiol;Enriched Ringer's lactate solution
10 Thoracoabdominal Arortic CTA Study Completed NCT02291718 Phase 4 Isovue
11 Vasculopathic Injury and Plasma as Endothelial Rescue - OCTAplas Trial (EudraCT no. 2014-000452-28) Completed NCT02253082 Phase 4 OctaplasLG®
12 Study of the Effectiveness of Telmisartan in Slowing the Progression of Abdominal Aortic Aneurysms Completed NCT01683084 Phase 4 Telmisartan;Placebo
13 Statin Use in Abdominal Aortic Aneurysm Repair Completed NCT01062802 Phase 4 Atorvastatin
14 Endovascular Repair of Abdominal Aortic Aneurysms Completed NCT00803075 Phase 4
15 Endovascular Repair of Descending Thoracic Aortic Aneurysms Completed NCT00802984 Phase 4
16 GORE EXCLUDER® Endoprosthesis - Low Permeability in Treatment of Abdominal Aortic Aneurysms Completed NCT00593814 Phase 4
17 Standard Open Surgery Versus Endovascular Repair of Abdominal Aortic Aneurysm (AAA) Completed NCT00094575 Phase 4
18 Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities. Completed NCT02107170 Phase 4 Sevoflurane;Propofol;Remifentanil
19 Fibrinogen as an Alternative to FFP in Aortic Surgery. Completed NCT00994045 Phase 4
20 Eplerenone in the Management of Abdominal Aortic Aneurysms Recruiting NCT02345590 Phase 4 Eplerenone
21 Bloodtranfusions After Aortic Surgery Recruiting NCT02299947 Phase 4 Haemocomplettan P;Placebo
22 Randomized Preventive Vascular Screening Trial of 65-74 Year Old Men in the Central Region of Denmark Recruiting NCT00662480 Phase 4
23 Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Randomized Clinical Trial Recruiting NCT02678728 Phase 4 Dexmedetomidine;normal saline
24 Post-Market Study to Assess Outcomes of Patients Treated With AFX System Compared to Other EVAR Devices Enrolling by invitation NCT02407457 Phase 4
25 A Safety and Efficacy Study of Blood Pressure Control in Acute Aortic Emergencies - A Pilot Study (PROMPT) Terminated NCT01033370 Phase 4 clevidipine.
26 Long-term Benefit of Aortic Stent-graft in Patients With Distal Aortic Dissection Terminated NCT01354119 Phase 4
27 Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic Aneurysms Terminated NCT00409344 Phase 4 Dexmedetomidine
28 Comparison of Surveillance Versus Aortic Endografting for Small Aneurysm Repair Terminated NCT00118573 Phase 4
29 ATLANTIS:Extensive Type A Dissections and Thoracic/ Thoraco-Abdominal Aneurysms Repair With LupiAe Hybrid TechNique Withdrawn NCT01107366 Phase 4
30 Magnetic Resonance Imaging of Aortic Aneurysm Instability Unknown status NCT00794092 Phase 2, Phase 3 Sinerem administration
31 34mm Cuff Study for Endovascular Repair of Abdominal Aortic Aneurysms Unknown status NCT00706394 Phase 2, Phase 3
32 NExT ERA: National Expertise Based Trial of Elective Repair of Abdominal Aortic Aneurysms: A Pilot Study Unknown status NCT00358085 Phase 3
33 Study of Aortic Root Reimplantation Procedure Unknown status NCT01787604 Phase 3
34 Clinical Evaluation of a Modular Extracorporeal Circulation Circuit Unknown status NCT02000544 Phase 3
35 To Evaluate the Safety and Efficacy for GORE TAG Thoracic Endoprosthesis in the Treatment of Thoracic Aortic Disease Completed NCT00757003 Phase 3
36 INSTEAD Trial: INvestigation of STEnt Grafts in Patients With Type B Aortic Dissection Completed NCT00525356 Phase 3
37 VALOR: The Talent Thoracic Stent Graft System Clinical Study Completed NCT00604799 Phase 2, Phase 3
38 Powerlink Bifurcated Stent Graft Long-Term Follow-up Study Completed NCT00543270 Phase 2, Phase 3
39 ARBITER-II: Aorfix™ Bifurcated Safety and Performance Trial: Phase II, Angulated Vessels Completed NCT00442065 Phase 2, Phase 3
40 Melatonin and Cardiac Outcome After Major Surgery Completed NCT00315926 Phase 2, Phase 3 Melatonin;Placebo
41 Study of the Endovascular QUANTUM LP™ Stent Graft System in Abdominal Aortic Aneurysms (AAA) Completed NCT00233688 Phase 3
42 Prevention of Colon Ischemia During Aortic Aneurysm (AAA) Repair Completed NCT00671203 Phase 3
43 Conservative Aortic Valve Surgery for Aortic Insufficiency and Aneurysms of the Aortic Root. CAVIAAR Completed NCT00478803 Phase 3
44 Curcumin to Prevent Complications After Elective Abdominal Aortic Aneurysm (AAA) Repair Completed NCT01225094 Phase 2, Phase 3 curcumin
45 Lowering the Risk of Operative Complications Using Atorvastatin Loading Dose Completed NCT01543555 Phase 3 Atorvastatin;Placebo
46 Efficacy of the Ultrasound-guided Transversus Abdominis Plane Block in Open Aortic Abdominal Aneurysm Repair Surgery Recruiting NCT02292667 Phase 3 PCA with Chlorhydrate of Morphine;Acetaminophen
47 Effect of Tranexamic Acid in Ruptured Abdominal Aortic Aneurysms Recruiting NCT02125890 Phase 3 Tranexamic Acid
48 Comparison of Mycophenolate Mofetil and Cyclophosphamide for Active Takayasu's Arteritis Recruiting NCT03096275 Phase 3 MMF;CYC;Glucocorticoids;MTX;AZA
49 Efficacy and Tolerance of Tocilizumab In Takayasu Arteritis Recruiting NCT02101333 Phase 3 Tocilizumab
50 Clinical Study of the TriVascular Ovation™ Abdominal Stent Graft System Active, not recruiting NCT01092117 Phase 3

Search NIH Clinical Center for Aortic Disease

Cochrane evidence based reviews: aortic diseases

Genetic Tests for Aortic Disease

Anatomical Context for Aortic Disease

MalaCards organs/tissues related to Aortic Disease:

41
Heart, Endothelial, Testes, Spinal Cord, Kidney, Colon, Brain

Publications for Aortic Disease

Articles related to Aortic Disease:

(show top 50) (show all 358)
# Title Authors Year
1
Correction: Sex, pregnancy and aortic disease in Marfan syndrome. ( 29758081 )
2018
2
Clinical experience of positron-emission tomography in infective aortic disease. ( 29239196 )
2018
3
Impact of Pathogenic <i>FBN1</i> Variant Types on the Progression of Aortic Disease in Patients With Marfan Syndrome. ( 29848614 )
2018
4
One-year experience of a regional service model of teleconsultation for planning and treatment of complex thoracoabdominal aortic disease. ( 29336903 )
2018
5
MR Imaging of Thoracic Aortic Disease. ( 29613964 )
2018
6
Spectrum of Aortic Disease in the Giant Cell Arteritis Population. ( 29291886 )
2018
7
Expert consensus recommendations on the cardiogenetic care for patients with thoracic aortic disease and their first-degree relatives. ( 29452988 )
2018
8
Familial aortic disease and a large duplication in chromosome 16p13.1. ( 29441698 )
2018
9
X Marks the Spot: The Profound Impact of Sex on Aortic Disease. ( 29282246 )
2018
10
The Results of In Situ Prosthetic Graft Replacement for Infected Aortic Disease. ( 29411065 )
2018
11
Heart failure and sudden cardiac death in heritable thoracic aortic disease caused by pathogenic variants in the SMAD3 gene. ( 29717556 )
2018
12
Differential mRNA expression of inflammasome genes NLRP1 and NLRP3 in abdominal aneurysmal and occlusive aortic disease. ( 29528779 )
2018
13
Differential mRNA expression of inflammasome genes NLRP1 and NLRP3 in abdominal aneurysmal and occlusive aortic disease. ( 29347884 )
2018
14
Immunoglobulin G4-Related Aortic Disease. ( 29780068 )
2018
15
Variants of Unknown Significance in Genes Associated with Heritable Thoracic Aortic Disease Can Be Low Penetrant &amp;quot;Risk Variants&amp;quot;. ( 29961567 )
2018
16
Use of clampless facilitating devices in patients with low-grade aortic disease: is the cost justified by the theoretic risk reduction? ( 29653658 )
2018
17
MYLK pathogenic variants aortic disease presentation, pregnancy risk, and characterization of pathogenic missense variants. ( 29925964 )
2018
18
Treatment of patients with aortic disease during pregnancy and after delivery. ( 28587539 )
2017
19
Clinical profile of patients with cardiac arrest induced by aortic disease. ( 28830716 )
2017
20
Endovascular Treatment of Complex Aortic Disease with Parallel-Graft Endovascular Aneurysm Repair. Retrospective Analysis of a Single Center Experience and Midterm Results. ( 28943486 )
2017
21
Traditional Cardiovascular Risk Factors and Their Relation to Future Surgery for Valvular Heart Disease or Ascending Aortic Disease: AA Case-Referent Study. ( 28476875 )
2017
22
More than just numbers: Counting thoracic aortic disease just isn't that simple. ( 29329801 )
2017
23
Statins in aortic disease. ( 29141531 )
2017
24
Medical management of aortic disease in Marfan syndrome. ( 29270377 )
2017
25
Right brachial access is safe for branched endovascular aneurysm repair in complex aortic disease. ( 28268106 )
2017
26
Clinical Outcomes for Endovascular Repair of Thoracic Aortic Disease Using the Seal Thoracic Stent Graft: A Korean Multicenter Retrospective Study. ( 28258801 )
2017
27
Aortic disease: The quest to improve patient outcomes. ( 28126171 )
2017
28
Aortic Disease: Past and Present. ( 28683914 )
2017
29
Infective endocarditis and thoracic aortic disease: A review on forgotten psychological aspects. ( 28824792 )
2017
30
Natural history of the proximal aorta in patients with descending thoracic aortic disease. ( 29276106 )
2017
31
Neurologic Complications of Cardiac and Aortic Disease. ( 28570323 )
2017
32
Sex, pregnancy and aortic disease in Marfan syndrome. ( 28708846 )
2017
33
Treatment of Complex Thoracoabdominal Aortic Disease. ( 28683910 )
2017
34
Alcohol consumption and mortality from aortic disease among Japanese men: The Japan Collaborative Cohort study. ( 28982024 )
2017
35
Guidelines for the management of thoracic aortic disease in 2017. ( 29030719 )
2017
36
Treating Aortic Disease. ( 28388774 )
2017
37
Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome. ( 28067899 )
2017
38
Evolving treatment options for valve and aortic disease with bicuspid aortic valve. ( 28861430 )
2017
39
Peripheral Artery Disease and Aortic Disease. ( 27741978 )
2016
40
Simple Renal Cysts as Markers of Thoracic Aortic Disease. ( 26746998 )
2016
41
Guilt by association: a paradigm for detection of silent aortic disease. ( 27386404 )
2016
42
Spectrum of Abdominal Aortic Disease in a Tertiary Health Care Setup: MDCT Based Observational Study. ( 28050476 )
2016
43
The future of aortic disease: Our 'aneurysm moonshot'. ( 27209289 )
2016
44
Canadian Cardiovascular Society/Canadian Society of Cardiac Surgeons/Canadian Society for Vascular Surgery Joint Position Statement on Open and Endovascular Surgery for Thoracic Aortic Disease. ( 27233892 )
2016
45
Fenestrated and Branched Stent Grafting in Complex Aneurysmatic Aortic Disease: A Single-Center Early Experience. ( 27890847 )
2016
46
Early evaluation of precise deployment with the new low profile Zenith Alpha Thoracic Endoprosthesis in thoracic aortic disease. ( 27098214 )
2016
47
Marfan syndrome associated aortic disease in neonates and children: a clinical-morphologic review. ( 27479044 )
2016
48
Hybrid management in adult congenital aortic disease: An established approach. ( 27423849 )
2016
49
Pregnancy and Thoracic Aortic Disease: Managing the Risks. ( 26604124 )
2016
50
A Decade of Discovery in the Genetic Understanding of Thoracic Aortic Disease. ( 26724507 )
2016

Variations for Aortic Disease

Expression for Aortic Disease

Search GEO for disease gene expression data for Aortic Disease.

Pathways for Aortic Disease

Pathways related to Aortic Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 ACTA2 EFEMP2 ELN FBN1 IL6 NOTCH1
2
Show member pathways
13.72 ACTA2 IL6 MMP2 MMP9 NOTCH1 SMAD4
3
Show member pathways
13.37 ACTA2 EFEMP2 ELN FBN1 MMP2 MMP9
4
Show member pathways
13.28 ACTA2 IL6 NOTCH1 SMAD4 TGFB2 TGFBR1
5
Show member pathways
13.04 ACTA2 MMP2 MMP9 PRKG1 TGFBR1 TGFBR2
6
Show member pathways
13 ACTA2 EFEMP2 ELN FBN1 IL6 TGFB2
7
Show member pathways
12.86 ACTA2 IL6 TGFB2 TGFBR1 TGFBR2
8
Show member pathways
12.86 MMP9 SMAD4 TGFB2 TGFBR1 TGFBR2
9
Show member pathways
12.77 NOTCH1 SMAD4 TGFB2 TGFBR1 TGFBR2
10 12.69 IL6 MMP2 MMP9 NOTCH1 SMAD4 TGFB2
11
Show member pathways
12.57 IL6 MMP9 SMAD4 TGFB2 TGFBR1
12
Show member pathways
12.51 ADAMTS1 EFEMP2 ELN FBN1 MMP2 MMP9
13
Show member pathways
12.5 MMP2 MMP9 SMAD4 TGFB2 TGFBR1 TGFBR2
14
Show member pathways
12.46 SMAD4 TGFB2 TGFBR1 TGFBR2
15 12.42 IL6 SMAD4 TGFB2 TGFBR1 TGFBR2
16
Show member pathways
12.39 IL6 NOTCH1 SMAD4 TGFB2 TGFBR1 TGFBR2
17 12.25 NOTCH1 SMAD4 TGFB2 TGFBR1
18
Show member pathways
12.23 SMAD4 TGFB2 TGFBR1 TGFBR2
19
Show member pathways
12.22 IL6 SMAD4 TGFB2 TGFBR1 TGFBR2
20 12.17 IL6 TGFB2 TGFBR1 TGFBR2
21 12.15 SMAD4 TGFB2 TGFBR1 TGFBR2
22
Show member pathways
12.12 IL6 MMP2 TGFBR1 TGFBR2
23
Show member pathways
12.06 IL6 SMAD4 TGFB2 TGFBR1 TGFBR2 TIMP1
24
Show member pathways
12.06 IL6 SMAD4 TGFB2 TGFBR1 TGFBR2
25 11.99 IL6 MMP2 MMP9 TIMP1
26 11.96 ACTA2 MMP2 SMAD4 TGFB2 TGFBR1 TGFBR2
27
Show member pathways
11.9 MMP2 MMP9 TIMP1
28 11.89 SMAD4 TGFB2 TGFBR1 TGFBR2
29
Show member pathways
11.87 IL6 SMAD4 TGFBR1 TGFBR2
30
Show member pathways
11.83 CRP IL6 TIMP1
31 11.81 SMAD4 TGFB2 TGFBR1 TGFBR2
32
Show member pathways
11.78 SMAD4 TGFBR1 TGFBR2
33 11.75 SMAD4 TGFBR1 TGFBR2
34 11.74 SMAD4 TGFBR1 TGFBR2
35
Show member pathways
11.73 SMAD4 TGFBR1 TGFBR2
36
Show member pathways
11.72 EFEMP2 ELN FBN1 TGFB2
37 11.72 IL6 MMP2 MMP9 SMAD4 TGFB2 TGFBR1
38 11.69 ADAMTS1 MMP9 TGFB2
39 11.69 IL6 MMP2 MMP9
40
Show member pathways
11.67 IL6 MMP2 MMP9
41 11.66 MMP2 MMP9 TIMP1
42 11.63 SMAD4 TGFBR1 TGFBR2
43 11.63 IL6 MMP2 SMAD4 TGFB2 TGFBR1 TGFBR2
44 11.6 IL6 MMP2 TGFB2
45 11.56 IL6 SMAD4 TGFBR1
46 11.56 SMAD4 TGFBR1 TGFBR2
47 11.54 TGFB2 TGFBR1 TGFBR2
48 11.53 IL6 MMP2 MMP9
49 11.52 ELN IL6 MMP2 MMP9 TIMP1
50 11.49 APOE IL6 TGFBR1

GO Terms for Aortic Disease

Cellular components related to Aortic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.9 ACTA2 APOE CRP EFEMP2 FBN1 IL6
2 extracellular region GO:0005576 9.77 ADAMTS1 APOE CRP EFEMP2 ELN FBN1
3 endoplasmic reticulum lumen GO:0005788 9.67 APOE FBN1 IL6 TIMP1
4 basement membrane GO:0005604 9.56 ADAMTS1 EFEMP2 FBN1 TIMP1
5 transforming growth factor beta receptor complex GO:0070022 9.32 TGFBR1 TGFBR2
6 extracellular matrix GO:0031012 9.17 APOE ELN FBN1 MMP2 MMP9 TGFB2

Biological processes related to Aortic Disease according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.99 NOTCH1 SMAD4 TGFB2 TGFBR2
2 regulation of gene expression GO:0010468 9.99 APOE NOTCH1 TGFBR1 TGFBR2
3 angiogenesis GO:0001525 9.98 MMP2 NOTCH1 TGFB2 TGFBR1
4 heart development GO:0007507 9.96 FBN1 NOTCH1 TGFB2 TGFBR1 TGFBR2
5 in utero embryonic development GO:0001701 9.95 NOTCH1 SMAD4 TGFBR1 TGFBR2
6 response to hypoxia GO:0001666 9.94 MMP2 SMAD4 TGFB2 TGFBR2
7 skeletal system development GO:0001501 9.93 FBN1 MMP9 TGFB2 TGFBR1
8 cellular protein metabolic process GO:0044267 9.91 APOE FBN1 IL6 MMP2 TIMP1
9 male gonad development GO:0008584 9.88 REN SMAD4 TGFB2 TGFBR1
10 response to organic substance GO:0010033 9.87 REN TGFBR2 TIMP1
11 transforming growth factor beta receptor signaling pathway GO:0007179 9.85 SMAD4 TGFB2 TGFBR1 TGFBR2
12 wound healing GO:0042060 9.84 TGFB2 TGFBR1 TGFBR2 TIMP1
13 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.81 SMAD4 TGFB2 TGFBR1
14 embryo implantation GO:0007566 9.8 MMP2 MMP9 TGFBR2
15 roof of mouth development GO:0060021 9.8 SMAD4 TGFB2 TGFBR1 TGFBR2
16 epithelial to mesenchymal transition GO:0001837 9.78 NOTCH1 TGFB2 TGFBR1
17 neuron fate commitment GO:0048663 9.76 NOTCH1 SMAD4 TGFBR1
18 outflow tract septum morphogenesis GO:0003148 9.74 SMAD4 TGFB2 TGFBR2
19 interleukin-6-mediated signaling pathway GO:0070102 9.7 IL6 SMAD4
20 cardiac muscle cell proliferation GO:0060038 9.7 NOTCH1 TGFB2
21 positive regulation of SMAD protein signal transduction GO:0060391 9.69 SMAD4 TGFBR1
22 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.69 NOTCH1 SMAD4
23 somatic stem cell division GO:0048103 9.68 NOTCH1 TGFB2
24 cardiac left ventricle morphogenesis GO:0003214 9.68 NOTCH1 TGFBR2
25 pulmonary valve morphogenesis GO:0003184 9.67 NOTCH1 TGFB2
26 membranous septum morphogenesis GO:0003149 9.67 TGFB2 TGFBR2
27 response to cholesterol GO:0070723 9.67 TGFBR1 TGFBR2
28 endothelial cell activation GO:0042118 9.66 SMAD4 TGFBR1
29 negative regulation of lipid storage GO:0010888 9.66 CRP IL6
30 cGMP-mediated signaling GO:0019934 9.65 APOE PRKG1
31 coronary artery morphogenesis GO:0060982 9.65 NOTCH1 TGFBR1
32 ventricular trabecula myocardium morphogenesis GO:0003222 9.65 NOTCH1 TGFB2 TGFBR1
33 extracellular matrix disassembly GO:0022617 9.65 ELN FBN1 MMP2 MMP9 TIMP1
34 endocardial cell differentiation GO:0060956 9.64 NOTCH1 SMAD4
35 cardiac epithelial to mesenchymal transition GO:0060317 9.63 NOTCH1 TGFB2 TGFBR1
36 glomerular mesangial cell development GO:0072144 9.62 ACTA2 NOTCH1
37 regulation of transforming growth factor beta2 production GO:0032909 9.61 SMAD4 TGFB2
38 pathway-restricted SMAD protein phosphorylation GO:0060389 9.61 TGFB2 TGFBR1 TGFBR2
39 endocardial cushion fusion GO:0003274 9.6 TGFB2 TGFBR2
40 secondary palate development GO:0062009 9.58 SMAD4 TGFB2 TGFBR2
41 positive regulation of epithelial to mesenchymal transition GO:0010718 9.55 NOTCH1 SMAD4 TGFB2 TGFBR1 TGFBR2
42 atrioventricular valve morphogenesis GO:0003181 9.54 NOTCH1 TGFB2 TGFBR2
43 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.5 TGFB2 TGFBR1 TGFBR2
44 kidney development GO:0001822 9.43 ADAMTS1 FBN1 REN SMAD4 TGFB2 TGFBR1
45 ventricular septum morphogenesis GO:0060412 9.02 NOTCH1 SMAD4 TGFB2 TGFBR1 TGFBR2
46 positive regulation of cell proliferation GO:0008284 10.07 IL6 NOTCH1 TGFB2 TGFBR1 TGFBR2 TIMP1
47 negative regulation of cell proliferation GO:0008285 10 ADAMTS1 IL6 NOTCH1 SMAD4 TGFB2 TGFBR2

Molecular functions related to Aortic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity GO:0004702 9.4 TGFBR1 TGFBR2
2 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.37 TGFBR1 TGFBR2
3 extracellular matrix structural constituent GO:0005201 9.33 EFEMP2 ELN FBN1
4 I-SMAD binding GO:0070411 9.32 SMAD4 TGFBR1
5 type II transforming growth factor beta receptor binding GO:0005114 8.96 TGFB2 TGFBR1
6 transforming growth factor beta-activated receptor activity GO:0005024 8.62 TGFBR1 TGFBR2
7 protein binding GO:0005515 10.19 AAAS APOE CRP EFEMP2 ELN FBN1

Sources for Aortic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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