MCID: ART017
MIFTS: 56

Aortic Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Aortic Disease

MalaCards integrated aliases for Aortic Disease:

Name: Aortic Disease 12 15 17
Aortic Diseases 56 45 74
Disorder of the Aorta 12
Aortic Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:520
MeSH 45 D001018
NCIt 51 C101253
SNOMED-CT 69 47040006
ICD10 34 I35.9
UMLS 74 C0003493

Summaries for Aortic Disease

Disease Ontology : 12 An artery disease that is characterized by degeneration of the cells composing the aortic wall.

MalaCards based summary : Aortic Disease, also known as aortic diseases, is related to marfan syndrome and aortic aneurysm. An important gene associated with Aortic Disease is FBN1 (Fibrillin 1), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Acetazolamide and Morphine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Aortic Disease

Diseases related to Aortic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
# Related Disease Score Top Affiliating Genes
1 marfan syndrome 30.3 ACTA2 ELN FBN1 MMP2 TGFBR1 TGFBR2
2 aortic aneurysm 30.1 ACTA2 EFEMP2 ELN FBN1 MYH11 MYLK
3 sleep apnea 29.2 APOE CRP IL6 REN
4 inguinal hernia 29.1 ELN FBN1 IL6 MMP2 MMP9
5 takayasu arteritis 29.1 CRP IL6 MMP9
6 arteries, anomalies of 29.0 APOE CRP IL6 MMP9 REN
7 loeys-dietz syndrome 28.8 ACTA2 FBN1 MYH11 MYLK TGFB2 TGFBR1
8 tetralogy of fallot 28.7 CRP FBN1 MMP9 NOTCH1 REN
9 heart disease 28.6 APOE CRP ELN IL6 NOTCH1 REN
10 aortic aneurysm, familial thoracic 1 28.2 ACTA2 EFEMP2 ELN FBN1 MMP2 MYH11
11 heritable thoracic aortic disease 12.2
12 calcific aortic disease with immunologic abnormalities, familial 12.0
13 aorta atresia 10.9
14 pseudoxanthoma elasticum-like papillary dermal elastolysis 10.5 ELN FBN1
15 late-onset focal dermal elastosis 10.5 ELN FBN1
16 aortic aneurysm, familial thoracic 2 10.4 ACTA2 FBN1
17 char syndrome 10.4 ACTA2 FBN1 TGFBR2
18 familial thoracic aortic aneurysm and dissection 10.4 FBN1 TGFBR1 TGFBR2
19 loeys-dietz syndrome 4 10.4 TGFB2 TGFBR1 TGFBR2
20 familial abdominal aortic aneurysm 10.4 ELN FBN1 MYLK
21 acute adrenal insufficiency 10.4 IL6 REN
22 aortic valve insufficiency 10.3 ELN FBN1 NOTCH1
23 cerebral arterial disease 10.3 ACTA2 ELN MMP9
24 chronic actinic dermatitis 10.3 ELN FBN1 MMP9
25 cutis laxa, autosomal recessive, type ib 10.2 EFEMP2 ELN
26 connective tissue disease 10.2 ACTA2 ELN FBN1 IL6
27 exfoliation syndrome 10.2 APOE ELN FBN1
28 extracranial arteriovenous malformation 10.2 MMP2 MMP9
29 sorsby fundus dystrophy 10.2 ELN FBN1 MMP2
30 diabetic foot ulcers 10.2 IL6 MMP9
31 focal myositis 10.2 MMP2 MMP9
32 cutis laxa, autosomal recessive, type ic 10.2 EFEMP2 TGFBR1 TGFBR2
33 villous adenocarcinoma 10.2 MMP2 MMP9
34 arterial tortuosity syndrome 10.2 EFEMP2 ELN TGFBR1
35 spastic entropion 10.2 MMP2 MMP9
36 lentigo maligna melanoma 10.2 MMP2 MMP9
37 bone cancer 10.1 IL6 MMP9 NOTCH1
38 senile ectropion 10.1 ELN MMP2 MMP9
39 aortic aneurysm, familial thoracic 6 10.1 ACTA2 MYH11 MYLK
40 acute transverse myelitis 10.1 IL6 MMP2 MMP9
41 transverse myelitis 10.1 IL6 MMP2 MMP9
42 varicose veins 10.1 ELN MMP2 MMP9
43 autosomal recessive cutis laxa type i 10.1 EFEMP2 ELN TGFBR1 TGFBR2
44 cold agglutinin disease 10.1 CRP IL6
45 psammomatous meningioma 10.1 MMP2 MMP9
46 female reproductive system disease 10.0 IL6 MMP2 MMP9
47 reproductive system disease 10.0 IL6 MMP2 MMP9
48 tongue cancer 10.0 MMP2 MMP9 NOTCH1
49 mid-dermal elastolysis 10.0 ELN FBN1
50 pelvic organ prolapse 10.0 ELN MMP9 MYH11

Graphical network of the top 20 diseases related to Aortic Disease:



Diseases related to Aortic Disease

Symptoms & Phenotypes for Aortic Disease

GenomeRNAi Phenotypes related to Aortic Disease according to GeneCards Suite gene sharing:

27 (show all 50)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.2 EFEMP2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.2 EFEMP2 MMP2 SMAD4 TGFB2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.2 TGFBR1 TGFBR2 SMAD4 TGFB2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.2 MMP2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.2 TGFB2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.2 TGFBR2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.2 CRP NOTCH1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.2 TGFBR2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.2 MMP2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.2 TGFBR2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.2 TGFBR2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-133 10.2 TGFB2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10.2 NOTCH1 TGFB2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.2 CRP NOTCH1 TGFBR1 TGFBR2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.2 TGFBR2 EFEMP2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.2 CRP NOTCH1 EFEMP2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.2 TGFBR2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.2 TGFBR2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.2 TGFBR1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.2 TGFBR2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-188 10.2 TGFBR2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-195 10.2 SMAD4
23 Increased shRNA abundance (Z-score > 2) GR00366-A-196 10.2 TGFB2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.2 MMP2
25 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10.2 NOTCH1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.2 SMAD4
27 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.2 NOTCH1 TGFBR2
28 Increased shRNA abundance (Z-score > 2) GR00366-A-215 10.2 TGFB2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-22 10.2 TGFBR1 EFEMP2
30 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.2 SMAD4
31 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.2 EFEMP2
32 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.2 TGFBR1
33 Increased shRNA abundance (Z-score > 2) GR00366-A-37 10.2 TGFBR1
34 Increased shRNA abundance (Z-score > 2) GR00366-A-39 10.2 TGFBR2
35 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.2 SMAD4 TGFB2
36 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.2 SMAD4
37 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.2 SMAD4
38 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.2 CRP
39 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.2 TGFB2
40 Increased shRNA abundance (Z-score > 2) GR00366-A-54 10.2 SMAD4
41 Increased shRNA abundance (Z-score > 2) GR00366-A-6 10.2 NOTCH1
42 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.2 CRP MMP2
43 Increased shRNA abundance (Z-score > 2) GR00366-A-65 10.2 NOTCH1 TGFBR2 EFEMP2
44 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.2 TGFBR2
45 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.2 NOTCH1 TGFBR2 SMAD4 TGFB2
46 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.2 SMAD4
47 Increased shRNA abundance (Z-score > 2) GR00366-A-77 10.2 TGFBR1
48 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.2 TGFBR2 MMP2 SMAD4
49 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.2 TGFBR1
50 Increased shRNA abundance (Z-score > 2) GR00366-A-88 10.2 TGFBR1

MGI Mouse Phenotypes related to Aortic Disease:

47 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.52 ACTA2 APOE CRP EFEMP2 FBN1 IL6
2 homeostasis/metabolism MP:0005376 10.47 ADAMTS1 APOE CRP FBN1 IL6 MMP2
3 growth/size/body region MP:0005378 10.43 ADAMTS1 APOE FBN1 IL6 MMP2 MMP9
4 mortality/aging MP:0010768 10.41 ADAMTS1 APOE EFEMP2 FBN1 IL6 MMP2
5 cellular MP:0005384 10.4 APOE EFEMP2 FBN1 IL6 MMP9 MYH11
6 immune system MP:0005387 10.4 APOE CRP FBN1 IL6 MMP2 MMP9
7 hematopoietic system MP:0005397 10.36 APOE FBN1 IL6 MMP2 MMP9 NLRP3
8 muscle MP:0005369 10.36 ACTA2 APOE EFEMP2 FBN1 IL6 MMP2
9 digestive/alimentary MP:0005381 10.35 APOE IL6 MMP9 MYH11 MYLK NLRP3
10 endocrine/exocrine gland MP:0005379 10.22 ADAMTS1 APOE FBN1 IL6 NOTCH1 SMAD4
11 nervous system MP:0003631 10.22 APOE FBN1 IL6 MMP2 MMP9 NLRP3
12 integument MP:0010771 10.21 APOE EFEMP2 FBN1 IL6 MMP9 MYH11
13 renal/urinary system MP:0005367 10.13 ADAMTS1 APOE FBN1 IL6 MMP9 MYH11
14 normal MP:0002873 10.07 EFEMP2 MMP2 MYLK NLRP3 NOTCH1 PRKG1
15 limbs/digits/tail MP:0005371 10.04 APOE EFEMP2 FBN1 MMP9 NLRP3 SMAD4
16 neoplasm MP:0002006 9.98 IL6 MMP2 MMP9 NOTCH1 SMAD4 TGFBR1
17 reproductive system MP:0005389 9.96 ADAMTS1 APOE FBN1 IL6 MMP9 NLRP3
18 respiratory system MP:0005388 9.9 APOE EFEMP2 FBN1 IL6 MMP2 MMP9
19 skeleton MP:0005390 9.77 APOE EFEMP2 FBN1 IL6 MMP2 MMP9
20 vision/eye MP:0005391 9.28 ACTA2 APOE EFEMP2 IL6 MMP2 MMP9

Drugs & Therapeutics for Aortic Disease

Drugs for Aortic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 235)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
2
Morphine Approved, Investigational Phase 4,Phase 3 57-27-2 5288826
3
Ropivacaine Approved Phase 4,Phase 3 84057-95-4 71273 175805
4
Prednisolone phosphate Approved, Vet_approved Phase 4,Not Applicable 302-25-0
5
Prednisolone Approved, Vet_approved Phase 4,Not Applicable 50-24-8 5755
6
Methylprednisolone hemisuccinate Approved Phase 4,Not Applicable 2921-57-5
7
Methylprednisolone Approved, Vet_approved Phase 4,Not Applicable 83-43-2 6741
8
Iodine Approved, Investigational Phase 4,Not Applicable 7553-56-2 807
9
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
10
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
11
Remifentanil Approved Phase 4 132875-61-7 60815
12
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
13
Angiotensin II Approved, Investigational Phase 4,Not Applicable 68521-88-0, 11128-99-7, 4474-91-3 172198 65143
14
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
15
Atenolol Approved Phase 4 29122-68-7 2249
16
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
17
Atorvastatin Approved Phase 4,Phase 3,Not Applicable 134523-00-5 60823
18
Eplerenone Approved Phase 4 107724-20-9 150310 443872
19
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
20
Clevidipine Approved, Investigational Phase 4,Not Applicable 167221-71-8
21
Histidine Approved, Nutraceutical Phase 4 71-00-1 6274
22
Calcium Approved, Nutraceutical Phase 4,Phase 2,Not Applicable 7440-70-2 271
23
Prednisolone hemisuccinate Experimental Phase 4,Not Applicable 2920-86-7
24 Carbonic Anhydrase Inhibitors Phase 4
25 Natriuretic Agents Phase 4,Not Applicable
26 diuretics Phase 4,Not Applicable
27 Anticonvulsants Phase 4
28 Anesthetics Phase 4,Phase 3,Phase 1,Not Applicable
29 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
30 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
31 Analgesics, Opioid Phase 4,Phase 3
32 Narcotics Phase 4,Phase 3,Phase 2
33 Analgesics Phase 4,Phase 3,Phase 2,Not Applicable
34 Anesthetics, Local Phase 4,Phase 3
35 Prednisolone acetate Phase 4,Not Applicable
36 Methylprednisolone Acetate Phase 4,Not Applicable
37 cadexomer iodine Phase 4,Not Applicable
38 Autonomic Agents Phase 4,Not Applicable,Early Phase 1
39 Antimetabolites Phase 4,Phase 3,Not Applicable
40 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
42 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
43 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Not Applicable
44 Hypnotics and Sedatives Phase 4,Not Applicable
45 Platelet Aggregation Inhibitors Phase 4,Phase 2
46 Anesthetics, General Phase 4,Not Applicable
47 Anesthetics, Inhalation Phase 4,Not Applicable
48 Anesthetics, Intravenous Phase 4,Not Applicable
49 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1,Not Applicable
50 Tryptophan Phase 4

Interventional clinical trials:

(show top 50) (show all 569)
# Name Status NCT ID Phase Drugs
1 ESOS (Endoscopic Saphenous Harvesting With an Open CO2 System) Trial Unknown status NCT01121341 Phase 4
2 Prophylactic Mesh Implantation After Abdominal Aortic Aneurysm Repair Unknown status NCT01353443 Phase 4
3 Effectiveness of Acetazolamide in Reducing Paralysis of the Leg in Patients Undergoing Aortic Aneurysm Surgery Surgery Unknown status NCT01889498 Phase 4 Acetazolamide
4 Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
5 Effect of Anesthetics on CD39 and CD73 After Open-heart Surgery Completed NCT02136979 Phase 4 Propofol;Sevoflurane
6 Opioid-potentiated Volative Anaesthetic Vs. Remifentanil And Propofol During Abdominal Aortic Aneurysm Surgery Completed NCT00538421 Phase 4 Propofol;Sevoflurane
7 A Multicenter Study of Iomeron®-400 Used With Multi-detector Computed Tomography Angiography (MDCTA) Completed NCT02596048 Phase 4
8 TAP-Block in Abdominal Aortic Surgery Completed NCT03657979 Phase 4 Ropivacaine;Placebo
9 CUstodiol Versus RInger: whaT Is the Best Agent? Completed NCT02327611 Phase 4 Custodiol;Enriched Ringer's lactate solution
10 Thoracoabdominal Arortic CTA Study Completed NCT02291718 Phase 4 Isovue
11 Vasculopathic Injury and Plasma as Endothelial Rescue - OCTAplas Trial (EudraCT no. 2014-000452-28) Completed NCT02253082 Phase 4 OctaplasLG®
12 Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial) Completed NCT01904981 Phase 4 Beta-blocker-Atenolol 50mg, PO(peroral), Once daily;Angiotensin receptor blocker-Valsartan 80mg, PO(peroral), Once daily
13 Study of the Effectiveness of Telmisartan in Slowing the Progression of Abdominal Aortic Aneurysms Completed NCT01683084 Phase 4 Telmisartan;Placebo
14 Statin Use in Abdominal Aortic Aneurysm Repair Completed NCT01062802 Phase 4 Atorvastatin
15 Endovascular Repair of Abdominal Aortic Aneurysms Completed NCT00803075 Phase 4
16 Endovascular Repair of Descending Thoracic Aortic Aneurysms Completed NCT00802984 Phase 4
17 GORE EXCLUDER® Endoprosthesis - Low Permeability in Treatment of Abdominal Aortic Aneurysms Completed NCT00593814 Phase 4
18 Standard Open Surgery Versus Endovascular Repair of Abdominal Aortic Aneurysm (AAA) Completed NCT00094575 Phase 4
19 Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities. Completed NCT02107170 Phase 4 Sevoflurane;Propofol;Remifentanil
20 Fibrinogen as an Alternative to FFP in Aortic Surgery. Completed NCT00994045 Phase 4
21 Eplerenone in the Management of Abdominal Aortic Aneurysms Recruiting NCT02345590 Phase 4 Eplerenone
22 Predictors of AAA Expansion and/or Rupture Recruiting NCT03231397 Phase 4 Assess AAA rupture risk by PET-CTA scans;18F-fludeoxyglucose (FDG)
23 Bloodtranfusions After Aortic Surgery Recruiting NCT02299947 Phase 4 Haemocomplettan P;Placebo
24 Randomized Preventive Vascular Screening Trial of 65-74 Year Old Men in the Central Region of Denmark Recruiting NCT00662480 Phase 4
25 Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Randomized Clinical Trial Recruiting NCT02678728 Phase 4 Dexmedetomidine;normal saline
26 Post-Market Study to Assess Outcomes of Patients Treated With AFX System Compared to Other EVAR Devices Enrolling by invitation NCT02407457 Phase 4
27 A Safety and Efficacy Study of Blood Pressure Control in Acute Aortic Emergencies - A Pilot Study (PROMPT) Terminated NCT01033370 Phase 4 clevidipine.
28 Long-term Benefit of Aortic Stent-graft in Patients With Distal Aortic Dissection Terminated NCT01354119 Phase 4
29 Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic Aneurysms Terminated NCT00409344 Phase 4 Dexmedetomidine
30 Comparison of Surveillance Versus Aortic Endografting for Small Aneurysm Repair Terminated NCT00118573 Phase 4
31 ATLANTIS:Extensive Type A Dissections and Thoracic/ Thoraco-Abdominal Aneurysms Repair With LupiAe Hybrid TechNique Withdrawn NCT01107366 Phase 4
32 Efficacy of the Ultrasound-guided Transversus Abdominis Plane Block in Open Aortic Abdominal Aneurysm Repair Surgery Unknown status NCT02292667 Phase 3 PCA with Chlorhydrate of Morphine;Acetaminophen
33 Magnetic Resonance Imaging of Aortic Aneurysm Instability Unknown status NCT00794092 Phase 2, Phase 3 Sinerem administration
34 34mm Cuff Study for Endovascular Repair of Abdominal Aortic Aneurysms Unknown status NCT00706394 Phase 2, Phase 3
35 NExT ERA: National Expertise Based Trial of Elective Repair of Abdominal Aortic Aneurysms: A Pilot Study Unknown status NCT00358085 Phase 3
36 Study of Aortic Root Reimplantation Procedure Unknown status NCT01787604 Phase 3
37 Comparison of Mycophenolate Mofetil and Cyclophosphamide for Active Takayasu's Arteritis Unknown status NCT03096275 Phase 3 MMF;CYC;Glucocorticoids;MTX;AZA
38 Clinical Evaluation of a Modular Extracorporeal Circulation Circuit Unknown status NCT02000544 Phase 3
39 To Evaluate the Safety and Efficacy for GORE TAG Thoracic Endoprosthesis in the Treatment of Thoracic Aortic Disease Completed NCT00757003 Phase 3
40 INSTEAD Trial: INvestigation of STEnt Grafts in Patients With Type B Aortic Dissection Completed NCT00525356 Phase 3
41 VALOR: The Talent Thoracic Stent Graft System Clinical Study Completed NCT00604799 Phase 2, Phase 3
42 Powerlink Bifurcated Stent Graft Long-Term Follow-up Study Completed NCT00543270 Phase 2, Phase 3
43 ARBITER-II: Aorfix™ Bifurcated Safety and Performance Trial: Phase II, Angulated Vessels Completed NCT00442065 Phase 2, Phase 3
44 Melatonin and Cardiac Outcome After Major Surgery Completed NCT00315926 Phase 2, Phase 3 Melatonin;Placebo
45 Study of the Endovascular QUANTUM LP™ Stent Graft System in Abdominal Aortic Aneurysms (AAA) Completed NCT00233688 Phase 3
46 Prevention of Colon Ischemia During Aortic Aneurysm (AAA) Repair Completed NCT00671203 Phase 3
47 Conservative Aortic Valve Surgery for Aortic Insufficiency and Aneurysms of the Aortic Root. CAVIAAR Completed NCT00478803 Phase 3
48 Curcumin to Prevent Complications After Elective Abdominal Aortic Aneurysm (AAA) Repair Completed NCT01225094 Phase 2, Phase 3 curcumin
49 Lowering the Risk of Operative Complications Using Atorvastatin Loading Dose Completed NCT01543555 Phase 3 Atorvastatin;Placebo
50 Effect of Tranexamic Acid in Ruptured Abdominal Aortic Aneurysms Recruiting NCT02125890 Phase 3 Tranexamic Acid

Search NIH Clinical Center for Aortic Disease

Cochrane evidence based reviews: aortic diseases

Genetic Tests for Aortic Disease

Anatomical Context for Aortic Disease

MalaCards organs/tissues related to Aortic Disease:

42
Heart, Testes, Endothelial, Spinal Cord, Kidney, Brain, Colon

Publications for Aortic Disease

Articles related to Aortic Disease:

(show top 50) (show all 507)
# Title Authors Year
1
Congenital Thoracic Aortic Disease. ( 30454807 )
2019
2
SMAD3 pathogenic variants: risk for thoracic aortic disease and associated complications from the Montalcino Aortic Consortium. ( 30661052 )
2019
3
Prospective multicenter study of the low-profile Relay stent-graft in patients with thoracic aortic disease: the RE-GENERATION study. ( 30684621 )
2019
4
Routine genetic testing for thoracic aortic disease may levy high costs to patients with little benefit. ( 30696263 )
2019
5
Bicuspid aortic disease: "Marfan light"? ( 30704746 )
2019
6
Simple renal cysts and bovine aortic arch: markers for aortic disease. ( 30774963 )
2019
7
A review of aortic disease research in Malaysia. ( 30846666 )
2019
8
Exercise and sports participation in patients with thoracic aortic disease: a review. ( 30887852 )
2019
9
Genes, aortic diseases, and cardiovascular surgery. ( 29807775 )
2019
10
Computed Tomography of Acquired Aortic Diseases. ( 30454808 )
2019
11
Genetics of Thoracic and Abdominal Aortic Diseases. ( 30763214 )
2019
12
The role of thoracic endovascular repair in elective, symptomatic and ruptured thoracic aortic diseases. ( 30768171 )
2019
13
Evidence of parallel endografting for complex aortic diseases rising: Will the technique overcome perceived shadows and move to the next level in 2019 and beyond? ( 30786831 )
2019
14
Correction: Sex, pregnancy and aortic disease in Marfan syndrome. ( 29758081 )
2018
15
Clinical experience of positron-emission tomography in infective aortic disease. ( 29239196 )
2018
16
Impact of Pathogenic <i>FBN1</i> Variant Types on the Progression of Aortic Disease in Patients With Marfan Syndrome. ( 29848614 )
2018
17
One-year experience of a regional service model of teleconsultation for planning and treatment of complex thoracoabdominal aortic disease. ( 29336903 )
2018
18
MR Imaging of Thoracic Aortic Disease. ( 29613964 )
2018
19
Spectrum of Aortic Disease in the Giant Cell Arteritis Population. ( 29291886 )
2018
20
Expert consensus recommendations on the cardiogenetic care for patients with thoracic aortic disease and their first-degree relatives. ( 29452988 )
2018
21
Familial aortic disease and a large duplication in chromosome 16p13.1. ( 29441698 )
2018
22
X Marks the Spot: The Profound Impact of Sex on Aortic Disease. ( 29282246 )
2018
23
The Results of In Situ Prosthetic Graft Replacement for Infected Aortic Disease. ( 29411065 )
2018
24
Heart failure and sudden cardiac death in heritable thoracic aortic disease caused by pathogenic variants in the SMAD3 gene. ( 29717556 )
2018
25
Differential mRNA expression of inflammasome genes NLRP1 and NLRP3 in abdominal aneurysmal and occlusive aortic disease. ( 29528779 )
2018
26
Differential mRNA expression of inflammasome genes NLRP1 and NLRP3 in abdominal aneurysmal and occlusive aortic disease. ( 29347884 )
2018
27
Immunoglobulin G4-Related Aortic Disease. ( 29780068 )
2018
28
Variants of Unknown Significance in Genes Associated with Heritable Thoracic Aortic Disease Can Be Low Penetrant &amp;quot;Risk Variants&amp;quot;. ( 29961567 )
2018
29
Use of clampless facilitating devices in patients with low-grade aortic disease: is the cost justified by the theoretic risk reduction? ( 29653658 )
2018
30
MYLK pathogenic variants aortic disease presentation, pregnancy risk, and characterization of pathogenic missense variants. ( 29925964 )
2018
31
Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease. ( 30740444 )
2018
32
Medical management of aortic disease in children with Marfan syndrome. ( 30036202 )
2018
33
Surgery for Acute Presentation of Thoracoabdominal Aortic Disease. ( 30071280 )
2018
34
Frozen Elephant Trunk to Treat Coarctation Associated With Proximal Aortic Disease: Better to Be Smart Than Brave. ( 30194977 )
2018
35
Congenital heart and aortic disease: novel genetic causes, biomarkers, and effect of pregnancy. ( 30202969 )
2018
36
Finite element analysis in symptomatic and asymptomatic abdominal aortic aneurysms for aortic disease risk stratification. ( 30203637 )
2018
37
Treatment of thoracoabdominal aortic disease in patients with connective tissue disorders. ( 30244929 )
2018
38
Open surgery for descending thoracic aortic disease: "Pride and prejudice". ( 30249341 )
2018
39
Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome. ( 30257952 )
2018
40
Role of PET/CT in the Evaluation of Aortic Disease. ( 30288369 )
2018
41
Externalized transapical guidewire technique for complex aortic disease: a single-centre experience. ( 30351405 )
2018
42
Response by Takeda et al to Letter Regarding Article, "Impact of Pathogenic FBN1 Variant Types on the Progression of Aortic Disease in Patients With Marfan Syndrome". ( 30354332 )
2018
43
Letter by Groth et al Regarding Article, "Impact of Pathogenic FBN1 (Fibrillin-1) Variant Types on the Progression of Aortic Disease in Patients With Marfan Syndrome". ( 30354333 )
2018
44
Aortic arch tortuosity, a novel biomarker for thoracic aortic disease, is increased in adults with bicuspid aortic valve. ( 30366853 )
2018
45
Systematic Review of Studies That Have Evaluated Screening Tests in Relatives of Patients Affected by Nonsyndromic Thoracic Aortic Disease. ( 30371227 )
2018
46
True, true, or unrelated? Fluoroquinolones and aortic disease. ( 30414764 )
2018
47
Coverage of visible intercostal and lumbar segmental arteries can predict the volume of cerebrospinal fluid drainage in elective endovascular repair of descending thoracic and thoracoabdominal aortic disease: a pilot study. ( 30428029 )
2018
48
Results of staged repair of aortic disease in patients with Marfan syndrome: Can we dramatically reduce the number of staged repairs? ( 30482531 )
2018
49
Aortic disease and interventions in adults with tetralogy of Fallot. ( 30514730 )
2018
50
Aortic stiffness in families with inherited non-syndromic thoracic aortic disease. ( 30606081 )
2018

Variations for Aortic Disease

Expression for Aortic Disease

Search GEO for disease gene expression data for Aortic Disease.

Pathways for Aortic Disease

Pathways related to Aortic Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 ACTA2 EFEMP2 ELN FBN1 IL6 MYH11
2
Show member pathways
13.75 ACTA2 IL6 MMP2 MMP9 NOTCH1 SMAD4
3
Show member pathways
13.28 ACTA2 IL6 MYH11 MYLK NOTCH1 SMAD4
4
Show member pathways
13.2 ACTA2 EFEMP2 ELN FBN1 MMP2 MMP9
5
Show member pathways
13.06 ACTA2 MMP2 MMP9 PRKG1 TGFBR1 TGFBR2
6
Show member pathways
13.06 ACTA2 EFEMP2 ELN FBN1 IL6 TGFB2
7
Show member pathways
12.93 ACTA2 MYH11 PRKG1 TGFB2 TGFBR1 TGFBR2
8
Show member pathways
12.87 MMP9 SMAD4 TGFB2 TGFBR1 TGFBR2
9
Show member pathways
12.87 ACTA2 IL6 MYLK TGFB2 TGFBR1 TGFBR2
10
Show member pathways
12.78 NOTCH1 SMAD4 TGFB2 TGFBR1 TGFBR2
11 12.76 IL6 MMP2 MMP9 NOTCH1 SMAD4 TGFB2
12
Show member pathways
12.71 ADAMTS1 EFEMP2 ELN FBN1 MMP2 MMP9
13
Show member pathways
12.59 IL6 NOTCH1 SMAD4 TGFB2 TGFBR1 TGFBR2
14
Show member pathways
12.47 SMAD4 TGFB2 TGFBR1 TGFBR2
15 12.37 IL6 SMAD4 TGFB2 TGFBR1 TGFBR2
16 12.26 NOTCH1 SMAD4 TGFB2 TGFBR1
17
Show member pathways
12.24 SMAD4 TGFB2 TGFBR1 TGFBR2
18 12.19 IL6 TGFB2 TGFBR1 TGFBR2
19
Show member pathways
12.18 ACTA2 EFEMP2 ELN FBN1 MMP2 MMP9
20 12.16 SMAD4 TGFB2 TGFBR1 TGFBR2
21
Show member pathways
12.13 IL6 MMP2 TGFBR1 TGFBR2
22
Show member pathways
12.1 IL6 SMAD4 TGFB2 TGFBR1 TGFBR2
23 12.1 ACTA2 MYLK SMAD4 TGFBR1
24
Show member pathways
12.09 IL6 SMAD4 TGFB2 TGFBR1 TGFBR2
25
Show member pathways
12.05 ADAMTS1 IL6 MMP2 MMP9
26
Show member pathways
12.05 IL6 SMAD4 TGFB2 TGFBR1 TGFBR2
27 11.96 ACTA2 MMP2 SMAD4 TGFB2 TGFBR1 TGFBR2
28 11.9 SMAD4 TGFB2 TGFBR1 TGFBR2
29
Show member pathways
11.88 IL6 SMAD4 TGFBR1 TGFBR2
30 11.85 SMAD4 TGFB2 TGFBR1 TGFBR2
31 11.76 SMAD4 TGFBR1 TGFBR2
32 11.76 SMAD4 TGFBR1 TGFBR2
33
Show member pathways
11.76 EFEMP2 ELN FBN1 TGFB2
34 11.75 IL6 MMP9 TGFB2
35
Show member pathways
11.74 SMAD4 TGFBR1 TGFBR2
36 11.72 IL6 MMP2 MMP9 SMAD4 TGFB2 TGFBR1
37 11.7 ADAMTS1 MMP9 TGFB2
38 11.7 IL6 MMP2 MMP9
39
Show member pathways
11.68 IL6 MMP2 MMP9
40 11.67 ELN IL6 MMP2 MMP9
41 11.64 SMAD4 TGFBR1 TGFBR2
42 11.63 IL6 MMP2 SMAD4 TGFB2 TGFBR1 TGFBR2
43 11.62 IL6 MMP2 TGFB2
44 11.58 IL6 SMAD4 TGFBR1
45 11.58 SMAD4 TGFBR1 TGFBR2
46 11.58 ACTA2 MMP2 SMAD4 TGFB2 TGFBR1 TGFBR2
47 11.56 TGFB2 TGFBR1 TGFBR2
48 11.54 IL6 MMP2 MMP9
49 11.51 TGFB2 TGFBR1 TGFBR2
50 11.51 APOE IL6 TGFBR1

GO Terms for Aortic Disease

Cellular components related to Aortic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.96 ACTA2 APOE CRP EFEMP2 FBN1 IL6
2 extracellular matrix GO:0031012 9.63 ADAMTS1 APOE ELN FBN1 MMP2 MMP9
3 basement membrane GO:0005604 9.5 ADAMTS1 EFEMP2 FBN1
4 extracellular region GO:0005576 9.44 ADAMTS1 APOE CRP EFEMP2 ELN FBN1
5 collagen-containing extracellular matrix GO:0062023 9.43 APOE ELN FBN1 MMP2 MMP9 TGFB2

Biological processes related to Aortic Disease according to GeneCards Suite gene sharing:

(show all 49)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.99 MMP2 NOTCH1 TGFB2 TGFBR1
2 positive regulation of cell migration GO:0030335 9.99 MMP9 MYLK NOTCH1 TGFBR1
3 regulation of gene expression GO:0010468 9.97 APOE NOTCH1 TGFBR1 TGFBR2
4 cellular protein metabolic process GO:0044267 9.95 APOE FBN1 IL6 MMP2
5 negative regulation of cell proliferation GO:0008285 9.95 ADAMTS1 IL6 NOTCH1 SMAD4 TGFB2 TGFBR2
6 in utero embryonic development GO:0001701 9.94 NOTCH1 SMAD4 TGFBR1 TGFBR2
7 regulation of cell proliferation GO:0042127 9.92 NOTCH1 SMAD4 TGFB2 TGFBR2
8 response to hypoxia GO:0001666 9.92 MMP2 SMAD4 TGFB2 TGFBR2
9 skeletal system development GO:0001501 9.9 FBN1 MMP9 TGFB2 TGFBR1
10 heart development GO:0007507 9.89 FBN1 NOTCH1 TGFB2 TGFBR1 TGFBR2
11 defense response to Gram-positive bacterium GO:0050830 9.88 CRP IL6 NLRP3
12 wound healing GO:0042060 9.88 TGFB2 TGFBR1 TGFBR2
13 male gonad development GO:0008584 9.83 REN SMAD4 TGFB2 TGFBR1
14 transforming growth factor beta receptor signaling pathway GO:0007179 9.81 SMAD4 TGFB2 TGFBR1 TGFBR2
15 outflow tract morphogenesis GO:0003151 9.8 ELN NOTCH1 TGFBR2
16 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.79 SMAD4 TGFB2 TGFBR1
17 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.78 ADAMTS1 MMP2 MMP9
18 embryo implantation GO:0007566 9.77 MMP2 MMP9 TGFBR2
19 epithelial to mesenchymal transition GO:0001837 9.73 NOTCH1 TGFB2 TGFBR1
20 neuron fate commitment GO:0048663 9.72 NOTCH1 SMAD4 TGFBR1
21 outflow tract septum morphogenesis GO:0003148 9.71 SMAD4 TGFB2 TGFBR2
22 cardiac muscle cell proliferation GO:0060038 9.7 NOTCH1 TGFB2
23 pulmonary valve morphogenesis GO:0003184 9.7 NOTCH1 TGFB2
24 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.69 NOTCH1 SMAD4
25 positive regulation of SMAD protein signal transduction GO:0060391 9.69 SMAD4 TGFBR1
26 cardiac left ventricle morphogenesis GO:0003214 9.68 NOTCH1 TGFBR2
27 endothelial cell activation GO:0042118 9.68 SMAD4 TGFBR1
28 membranous septum morphogenesis GO:0003149 9.68 TGFB2 TGFBR2
29 response to cholesterol GO:0070723 9.67 TGFBR1 TGFBR2
30 somatic stem cell division GO:0048103 9.67 NOTCH1 TGFB2
31 coronary artery morphogenesis GO:0060982 9.66 NOTCH1 TGFBR1
32 elastic fiber assembly GO:0048251 9.66 EFEMP2 MYH11
33 negative regulation of lipid storage GO:0010888 9.65 CRP IL6
34 endocardial cell differentiation GO:0060956 9.64 NOTCH1 SMAD4
35 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.63 IL6 NLRP3
36 ventricular trabecula myocardium morphogenesis GO:0003222 9.63 NOTCH1 TGFB2 TGFBR1
37 kidney development GO:0001822 9.63 ADAMTS1 FBN1 REN SMAD4 TGFB2 TGFBR1
38 secondary palate development GO:0062009 9.61 SMAD4 TGFB2 TGFBR2
39 endocardial cushion fusion GO:0003274 9.58 TGFB2 TGFBR2
40 glomerular mesangial cell development GO:0072144 9.58 ACTA2 NOTCH1
41 cardiac epithelial to mesenchymal transition GO:0060317 9.58 NOTCH1 TGFB2 TGFBR1
42 regulation of transforming growth factor beta2 production GO:0032909 9.57 SMAD4 TGFB2
43 pathway-restricted SMAD protein phosphorylation GO:0060389 9.54 TGFB2 TGFBR1 TGFBR2
44 atrioventricular valve morphogenesis GO:0003181 9.5 NOTCH1 TGFB2 TGFBR2
45 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.43 TGFB2 TGFBR1 TGFBR2
46 positive regulation of epithelial to mesenchymal transition GO:0010718 9.35 NOTCH1 SMAD4 TGFB2 TGFBR1 TGFBR2
47 ventricular septum morphogenesis GO:0060412 9.02 NOTCH1 SMAD4 TGFB2 TGFBR1 TGFBR2
48 positive regulation of cell proliferation GO:0008284 10.1 IL6 NOTCH1 TGFB2 TGFBR1 TGFBR2
49 positive regulation of gene expression GO:0010628 10.04 ACTA2 CRP IL6 NOTCH1 TGFBR1

Molecular functions related to Aortic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.58 APOE CRP EFEMP2 ELN FBN1 IL6
2 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.32 TGFBR1 TGFBR2
3 I-SMAD binding GO:0070411 9.26 SMAD4 TGFBR1
4 extracellular matrix constituent conferring elasticity GO:0030023 9.16 ELN FBN1
5 type II transforming growth factor beta receptor binding GO:0005114 8.96 TGFB2 TGFBR1

Sources for Aortic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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