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Aortic Dissection

Categories: Cardiovascular diseases
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Aliases & Classifications for Aortic Dissection

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MalaCards integrated aliases for Aortic Dissection:

Name: Aortic Dissection 11 75 53 5 14

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 11 DOID:0080685
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Summaries for Aortic Dissection

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Disease Ontology: 11 An aortic disease that is characterized by tearing of the intimal layer of the aorta resulting in separation of the layers of the aortic wall.

MalaCards based summary: Aortic Dissection is related to aortic aneurysm, familial thoracic 4 and marfan syndrome. An important gene associated with Aortic Dissection is FBN1 (Fibrillin 1), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include heart, smooth muscle and kidney, and related phenotypes are Decreased viability with paclitaxel and homeostasis/metabolism

Wikipedia: 75 Aortic dissection (AD) occurs when an injury to the innermost layer of the aorta allows blood to flow... more...
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Related Diseases for Aortic Dissection

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Diseases related to Aortic Dissection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 819)
# Related Disease Score Top Affiliating Genes
1 aortic aneurysm, familial thoracic 4 32.8 TGFBR1 TGFB3 TGFB2 SMAD3 PRKG1 MYH11
2 marfan syndrome 32.6 TGFBR1 TGFB2 MMP2 LOX FBN1 ELN
3 loeys-dietz syndrome 5 32.4 TGFBR1 TGFB3 TGFB2 SMAD3 FBN1
4 aortic aneurysm, familial thoracic 1 32.2 TGFBR1 TGFB3 TGFB2 TAGLN SMAD3 PRKG1
5 loeys-dietz syndrome 4 32.1 TGFBR1 TGFB3 TGFB2 SMAD3 MYH11 FBN1
6 aortic valve disease 2 31.9 FBN1 ELN CRP ACE
7 aortic valve insufficiency 31.9 TGFBR1 MYH11 FBN1 ELN EFEMP2 CRP
8 ehlers-danlos syndrome 31.7 TGFBR1 TGFB3 TGFB2 SMAD3 PRKG1 MYH11
9 aortitis 31.6 FBN1 ELN CRP
10 hemopericardium 31.6 FBN1 CRP
11 loeys-dietz syndrome 31.5 TGFBR1 TGFB3 TGFB2 TAGLN SMAD3 PRKG1
12 hemiplegia 31.4 MMP9 CRP ACTA2
13 stroke, ischemic 31.4 MMP9 LDLR FBN1 CRP ACE
14 loeys-dietz syndrome 1 31.3 TGFBR1 TGFB2 SMAD3 FBN1
15 takayasu arteritis 31.3 MMP9 MMP2 CRP
16 vascular disease 31.3 MMP9 MMP2 MIR145 LDLR FBN1 ELN
17 connective tissue disease 31.3 SMAD3 MMP9 MMP2 MIR145 LOX FBN1
18 mitral valve insufficiency 31.2 MYH11 FBN1 ELN CRP ACE
19 sleep apnea 31.1 MMP9 CRP ACE
20 cerebrovascular disease 31.1 MIR145 CRP ACTA2 ACE
21 aortic aneurysm 31.1 TGFBR1 TGFB3 TGFB2 TAGLN SMAD3 PRKG1
22 aortic aneurysm, familial abdominal, 1 31.1 TAGLN MYH11 MMP9 MMP2 LOX FBN1
23 mediastinitis 31.0 CRP ACE
24 pre-eclampsia 31.0 TGFB3 MMP9 MMP2 CRP ACE
25 aortic disease 31.0 TGFBR1 TGFB2 TAGLN SMAD3 MYH11 MMP9
26 atrial heart septal defect 31.0 MYH11 FBN1 ELN CRP ACE
27 carotid artery dissection 31.0 LDLR COL3A1
28 intermediate coronary syndrome 30.9 MIR145 CRP ACE
29 ehlers-danlos syndrome, vascular type 30.9 MYH11 FBN1 FBLN5 ELN EFEMP2 COL3A1
30 pneumothorax 30.9 MMP9 MMP2 FBN1 FBLN5 ELN CRP
31 tetralogy of fallot 30.8 MYH11 MMP9 FBN1 ELN CRP ACE
32 patent foramen ovale 30.8 FBN1 ELN CRP ACE
33 arteriosclerosis 30.8 MMP9 LOX FBN1 ELN CRP ACE
34 subclavian steal syndrome 30.8 CRP ACE
35 lipoprotein quantitative trait locus 30.7 TGFB2 TAGLN SMAD3 MYH11 MMP9 MIR145
36 brittle bone disorder 30.7 TGFB3 LOX FBN1 ELN COL3A1
37 pulmonary disease, chronic obstructive 30.7 MMP9 ELN CRP ACE
38 tricuspid valve insufficiency 30.7 MYH11 FBN1 CRP ACE
39 aortic valve disease 1 30.7 TGFBR1 TGFB3 TGFB2 TAGLN SMAD3 PRKG1
40 myocardial infarction 30.7 SMAD3 MMP9 MMP2 MIR145 LDLR ELN
41 coronary heart disease 1 30.6 LDLR CRP ACE
42 cholesterol embolism 30.6 CRP ACE
43 hypertrophic cardiomyopathy 30.6 TGFB3 PRKG1 MYH11 FBN1 ELN CRP
44 patent ductus arteriosus 1 30.6 TGFBR1 TGFB2 SMAD3 MYH11 FBN1 ELN
45 carotid stenosis 30.6 MMP9 CRP ACE
46 supravalvular aortic stenosis 30.6 MYH11 FBN1 FBLN5 ELN EFEMP2 ACTA2
47 gastroenteritis 30.6 MMP9 MMP2 CRP
48 decubitus ulcer 30.5 MMP9 ELN CRP
49 atherosclerosis susceptibility 30.5 MMP9 MMP2 LDLR ELN CRP ACE
50 collagen disease 30.5 TGFBR1 FBN1 ELN CRP COL3A1 ACTA2

Graphical network of the top 20 diseases related to Aortic Dissection:



Diseases related to Aortic Dissection
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Symptoms & Phenotypes for Aortic Dissection

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GenomeRNAi Phenotypes related to Aortic Dissection according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00207-A-2 8.62 FBLN5 TGFB3

MGI Mouse Phenotypes related to Aortic Dissection:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.46 ACE COL3A1 CRP ELN FBLN5 FBN1
2 muscle MP:0005369 10.44 ACTA2 COL3A1 EFEMP2 ELN FBLN5 FBN1
3 growth/size/body region MP:0005378 10.4 ACE COL3A1 EFEMP2 FBLN5 FBN1 LDLR
4 cardiovascular system MP:0005385 10.4 ACE ACTA2 COL3A1 CRP EFEMP2 ELN
5 renal/urinary system MP:0005367 10.25 ACE FBN1 LOX MMP2 MMP9 MYH11
6 cellular MP:0005384 10.25 ACE COL3A1 EFEMP2 FBLN5 FBN1 LDLR
7 digestive/alimentary MP:0005381 10.22 COL3A1 LDLR MMP2 MMP9 MYH11 PRKG1
8 immune system MP:0005387 10.21 ACE COL3A1 CRP FBN1 LDLR LOX
9 neoplasm MP:0002006 10.16 ACE FBLN5 LOX MMP2 MMP9 SMAD3
10 respiratory system MP:0005388 10.1 COL3A1 EFEMP2 ELN FBLN5 FBN1 LOX
11 limbs/digits/tail MP:0005371 10.07 EFEMP2 FBN1 LOX MMP9 SMAD3 TGFB2
12 craniofacial MP:0005382 10.06 FBLN5 FBN1 LOX MMP2 SMAD3 TGFB2
13 skeleton MP:0005390 10 EFEMP2 ELN FBN1 LOX MMP2 MMP9
14 hematopoietic system MP:0005397 9.93 ACE COL3A1 FBN1 LDLR LOX MMP2
15 mortality/aging MP:0010768 9.89 ACE COL3A1 EFEMP2 ELN FBN1 LDLR
16 integument MP:0010771 9.36 COL3A1 EFEMP2 FBLN5 FBN1 LDLR LOX
Sources

Drugs & Therapeutics for Aortic Dissection

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Drugs for Aortic Dissection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 110)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 4894 5755
4
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5 1875
5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 4159 6741
6
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7 4897
7 Gastrointestinal Agents Phase 4
8 Neuroprotective Agents Phase 4
9 Protective Agents Phase 4
10 Anti-Inflammatory Agents Phase 4
11 Antineoplastic Agents, Hormonal Phase 4
12 Hormones Phase 4
13 Hormone Antagonists Phase 4
14 Antiemetics Phase 4
15 glucocorticoids Phase 4
16
Methylprednisolone Acetate Phase 4 584547
17 Antihypertensive Agents Phase 3
18
Ketamine Approved, Vet_approved Phase 2 6740-88-1, 1867-66-9 3821
19
Naloxone Approved, Vet_approved Phase 2 465-65-6 5284596
20 Anesthetics, General Phase 2
21 Neurotransmitter Agents Phase 2
22 Excitatory Amino Acid Antagonists Phase 2
23 Anesthetics, Intravenous Phase 2
24 Anesthetics, Dissociative Phase 2
25 Analgesics, Opioid Phase 2
26
Urapidil Investigational Phase 1 34661-75-1
27 Adrenergic Antagonists Phase 1
28 Adrenergic alpha-1 Receptor Antagonists Phase 1
29 Adrenergic Agents Phase 1
30 Serotonin Receptor Agonists Phase 1
31
Serotonin Investigational, Nutraceutical Phase 1 50-67-9 5202
32
Edaravone Approved, Investigational 89-25-8 4021 70335
33
Tranexamic acid Approved 1197-18-8 5526
34
Nitric Oxide Approved 10102-43-9 145068
35
Acetylsalicylic acid Approved, Vet_approved 50-78-2 2244
36
Racepinephrine Approved, Vet_approved 51-43-4, 329-65-7 838 5816
37
Angiotensin II Approved, Investigational 68521-88-0, 11128-99-7, 4474-91-3 172198
38
Sodium fluoride Approved 7681-49-4
39
Heparin, bovine Approved, Investigational, Withdrawn 9005-49-6 22833565 9812414 772
40
Iron Approved 7439-89-6 29936
41
Thrombin Approved, Investigational
42
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
43
Tannic acid Approved 1401-55-4 16129878 16129778
44
Tazobactam Approved 89786-04-9 123630
45
Piperacillin Approved 66258-76-2 43672
46
Coal tar Approved 8007-45-2
47
Plasminogen Approved 9001-91-6
48
Castor oil Approved, Investigational, Nutraceutical, Vet_approved 8001-79-4 96919
49 Kava Approved, Investigational, Nutraceutical 9000-38-8
50
Creatine Approved, Investigational, Nutraceutical 57-00-1 586

Interventional clinical trials:

(show top 50) (show all 163)
# Name Status NCT ID Phase Drugs
1 Assessment of the Efficacy of Glucocorticoids in Improving Post-operative Organ Dysfunction in Patients With Acute Type A Aortic Dissection(GLAD): a Randomized Controlled Trial Recruiting NCT05329740 Phase 4 Methylprednisolone Injection
2 Long-term Benefit of Aortic Stent-graft in Patients With Distal Aortic Dissection Terminated NCT01354119 Phase 4
3 The Hemostatic Potential of TDM-621 on Ascending Aortic Surgery Unknown status NCT03917862 Phase 2, Phase 3
4 A Randomized Comparison of Strategies for Type B Aortic Dissection - the INvestigation of STEnt-grafts in Aortic Dissection (INSTEAD) Trial Completed NCT01415804 Phase 2, Phase 3
5 INvestigation of STEnt Grafts in Patients With Type B Aortic Dissection Completed NCT00525356 Phase 3
6 Safety and Efficacy of Fibrinogen Concentrate in Aortic Arch Surgery Involving Moderate Hypothermic Circulatory Arrest Unknown status NCT02542306 Phase 2 fibrinogen concentrate
7 A Randomized, Double-blind, Placebo-controlled, Study to Identify the Opioid-sparing Effects, and Pain-reduction Potential of Low Dose Ketamine on Patients Undergoing TEVAR Procedures Receiving NCI Recruiting NCT04600089 Phase 2 Saline;Ketamine
8 Intensive Blood PRessure Control in Patients With Acute Type B AortIc Dissection (RAID): Study Protocol for Randomized Controlled Trial Unknown status NCT03001739 Phase 1 Urapidil Hydrochloride Injection
9 Prospective Multicenter Study for Early Evaluation of Acute Chest Pain Unknown status NCT04122573
10 Cerebral and Spinal Protection of Xenon Post-conditioning in Patients Undergoing Aortic Dissection Repair Unknown status NCT02774096 xenon
11 The Relationship Between ALDH2 and Aortic Dissection Unknown status NCT02630212
12 Exploratory Study of Prognostic Factors in Aortic Dissection Type B: Role of Imaging (18F-FDG PET-Scan and Angioscan) and Biomarkers Unknown status NCT01984905
13 Clinical Study on Evaluation of Total Endovascular Aortic Arch Repair Unknown status NCT03347812
14 Superiority Trial of Type b Aortic Dissection Treatment Combined With Implantation of Bare Metal Stent in Abdominal Part of Aorta Versus Conventional Type b Treatment Unknown status NCT02726841
15 Triple-branch Stent Graft Placement and Total-arch Replacement for the Treatment of Acute DeBakey I Aortic Dissection: A Prospective, Multi-center, Randomized, Open-label, Parallel-group, Non-inferiority Clinical Trial Unknown status NCT02622750 Early Phase 1
16 A Validation Study of The Relationship Between ALDH2 and Aortic Dissection Unknown status NCT03780738
17 CT Evaluation of Intimal Flap Mobility as a Potential Predictor of Residual Type B Dissection Evolution Unknown status NCT03787277
18 A Multi-center Trial of Castor Single-Branched Stent Graft System for Endovascular Repair of Aortic Dissection. Unknown status NCT01914237
19 Mechanism and Early Intervention Research on Acute Lung Injury During Emergence Surgery of Acute Stanford A Aortic Dissection Unknown status NCT01894334 Ulinastatin;Tranexamic acid;Edaravone
20 Potential Biomarkers for Early Diagnosis of Acute Aortic Dissection Unknown status NCT01860768
21 Non Traumatic Aortic Dissection : Chain of Care and Pre-hospital Risk Factors, a Retrospective, Multicenter Study Unknown status NCT04304443
22 Mapping of Aortic Arch Hemodynamics by Biomechanical Analysis and Modeling for Planning Thoracic Endovascular Aortic Repair Unknown status NCT03824626
23 The Role of Thyroid Function in the Development and Prognosis of Stanford Type A Aortic Dissection. Unknown status NCT03146494
24 The Effect of Combination of Selective Antegrade Cerebral Perfusion With Retrograde Inferior Vena Caval Perfusion on the Outcomes in Patients Underwent Total Aortic Arch Replacement Unknown status NCT03607786
25 Inhaled Nitric Oxide as Salvage Treatment of Hypoxemia After Type A Acute Aortic Dissection Surgery (INSTEAD) Unknown status NCT04032366 inhaled nitric oxide
26 The Effects of Hemoperfusion in Acute Type A Aortic Dissection Patients Undergoing Cardiopulmonary Bypass and Deep Hypothermic Circulatory Arrest: A Randomized, Controlled, Double-blinded Trial Unknown status NCT04007484
27 Significance of Serum Tenascin C in Patients With Acute Aortic Disease Unknown status NCT02816892
28 A Single-center Trial of Patients With Aortic Dissection in the Chinese XinJiang Province Unknown status NCT02378103
29 Radiological Study of the Hemodynamic Changes in the Aorta and Its Branches Before and After Endovascular Treatment of the Aortic Dissection Unknown status NCT03669055
30 On-table Renal Perfusion Evaluation for Patients With Renal Artery Stenosis or Aortic Dissection With Renal Artery Obstruction Unknown status NCT03530748
31 Functional Study of Metabolites in Patients With Aortic Dissection Unknown status NCT04450433
32 Prognostic Value of Single-dose Glucocorticoid After Endovascular Repair for Aortic Dissection Unknown status NCT02523300 Glucocorticoids;saline
33 Endovascular Graft Anchoring Different Regions of Ascending Aorta in the Treatment of Ascending Aortic Dissection: a Prospective， Controlled and Multicenter Study Unknown status NCT04544579
34 Clinical Investigation of Chinese Patients With Aortic Dissection Unknown status NCT01552720
35 Retrospective Study of Acute Chest Pain in Extremely Critical Condition for More Than Ten Years Unknown status NCT02837120
36 Prospective Characterization of the Heart, Aorta and Blood Pressure in Women With Turner Syndrome. Association With Aortic Dissection. Unknown status NCT01678274
37 Mesenchymal Stem Cells for Multiple Organ Dysfuntion Syndrome After Surgical Repaire of Acute Type A Aortic Dissection: a Pilot Study Unknown status NCT03552848
38 Blood Pressure Control and Arterial Properties After Surgical Treatment of Type A Thoracic Aortic Dissection or Haematoma Unknown status NCT01068691
39 Clinical Characters, Treatment and Prognosis of the Young Patient With Aortic Dissection or Aneurysm: A Prospective Observational Cohort Study Unknown status NCT04431336
40 Protection of Xenon Against Postoperative Oxygen Impairment in Adults Undergoing Stanford Type-A Acute Aortic Dissection Surgery Unknown status NCT02468531 Xenon
41 Endovascular Aortic Repair for Aortic Dissection------XiJing Registry Unknown status NCT01505309
42 Hybrid Operation in Thoracic Aortic Dissection---Registry of China Unknown status NCT01500395
43 Zenith® Dissection Endovascular System in the Treatment of Patients With Acute, Complicated Type B Aortic Dissections Approved for marketing NCT02464943
44 Aortic Dissection Detection Risk Score Plus D-dimer in the Diagnostic Workup of Suspected Acute Aortic Dissection: a Prospective Multicenter Study Completed NCT02086136
45 The Study of The Chinese Registry of Acute Aortic Dissection and Clinical Study of Acute Aortic Dissection in Chinese Patients Completed NCT01606943
46 Surgery for Delay-recognized or Defer-operated Type A Aortic Dissection Completed NCT05044494
47 Triple-branch Stent Graft Placement for the Treatment of Acute DeBakey I Aortic Dissection: A Prospective, Single-center, Open-label, Non-controlled Clinical Trial Completed NCT02732340
48 Diagnostic Accuracy of Multislice CT Angiography for Acute Chest Pain - Assessment of Chest Pain Utilizing a Triple Rule Out Evaluation With Computed Tomography (ACUTE CT) Trial Completed NCT00855231
49 Zenith® Dissection Endovascular System Completed NCT02094300
50 The Roles of Intraluminal Pressure and the Dilation of Tunica Media in the Development of Aortic Dissection Completed NCT03030521

Search NIH Clinical Center for Aortic Dissection

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Genetic Tests for Aortic Dissection

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Anatomical Context for Aortic Dissection

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Organs/tissues related to Aortic Dissection:

MalaCards : Heart, Smooth Muscle, Kidney, Lung, Spinal Cord, Thyroid, Neutrophil
Sources

Publications for Aortic Dissection

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Articles related to Aortic Dissection:

(show top 50) (show all 15853)
# Title Authors PMID Year
1
FBN1 mutations in patients with descending thoracic aortic dissections. 53 62
20082464 2010
2
Comparison of clinical presentations and outcomes between patients with TGFBR2 and FBN1 mutations in Marfan syndrome and related disorders. 53 62
19996017 2009
3
Soluble elastin decreases in the progress of atheroma formation in human aorta. 53 62
19755752 2009
4
Comparison of computed radiography and multi-detector computed tomography in the detection of post mortem metacarpal index. 53 62
18353575 2008
5
[Aortic dissection]. 53 62
18413993 2008
6
What's new in the biochemical diagnosis of acute aortic dissection: problems and perspectives. 53 62
17660735 2007
7
Functional promoter polymorphism in the VKORC1 gene is no major genetic determinant for coronary heart disease in Northern Germans. 53 62
17549303 2007
8
Gene expression in acute Stanford type A dissection: a comparative microarray study. 53 62
16824202 2006
9
VKORC1 haplotypes are associated with arterial vascular diseases (stroke, coronary heart disease, and aortic dissection). 53 62
16549638 2006
10
Marfan syndrome: what internists and pediatric or adult cardiologists need to know. 53 62
16181034 2005
11
Decreased expression of fibulin-5 correlates with reduced elastin in thoracic aortic dissection. 53 62
16153447 2005
12
Coexistent aortic dissection and hepatocellular carcinoma with elevated plasma transforming growth factor beta level: possible roles of fibrillin 1 and transforming growth factor beta. 53 62
15678071 2005
13
[Soluble elastin fragments in serum are elevated in aortic dissection]. 53 62
15046049 2004
14
Diagnostic implications of elevated levels of smooth-muscle myosin heavy-chain protein in acute aortic dissection. The smooth muscle myosin heavy chain study. 53 62
11015167 2000
15
Collagen and elastin degradation by matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase in aortic dissection. 53 62
10872655 2000
16
Intracoronary serum smooth muscle myosin heavy chain levels following PTCA may predict restenosis. 53 62
10850529 2000
17
Biochemical diagnosis of aortic dissection: from bench to bedside. 53 62
10888373 1999
18
[Increased serum concentration of myosin heavy chain in aortic dissection: discussion of 2 cases]. 53 62
9324878 1997
19
Novel biochemical diagnostic method for aortic dissection. Results of a prospective study using an immunoassay of smooth muscle myosin heavy chain. 53 62
8653847 1996
20
Low expression of ESR1 correlates with ascending aortic dilation and acute type A aortic dissection. 62
36279950 2023
21
Intracranial hemorrhage with concurrent aortic dissection. 62
36324836 2023
22
11S Proteasome Activator REGγ Promotes Aortic Dissection by Inhibiting RBM3 (RNA Binding Motif Protein 3) Pathway. 62
36330811 2023
23
Peripheral Eosinophil Count Is Associated With the Prognosis of Patients With Type B Aortic Dissection Undergoing Endovascular Aortic Repair: A Retrospective Cohort Study. 62
36416154 2022
24
Construction of a canine model with acute type B aortic dissection using a self-made pressure water flow device. 62
36464272 2022
25
Guideline for the Treatment of Thoracic Aortic Dissection Type A: Summary of the S2k Guideline. 62
36462754 2022
26
Fluoroquinolones and the risk of aortic aneurysm or aortic dissection: an updated systematic review and meta-analysis including 53,651,283 patients. 62
36468763 2022
27
Upregulation of miR-222-3p alleviates the symptom of aortic dissection through targeting STAT3. 62
36216078 2022
28
Beta-blocker use after thoracic endovascular aortic repair in patients with type B aortic dissection is associated with improved early aortic remodeling. 62
35868420 2022
29
Aortic Root and Distal Arch Management During Type A Aortic Dissection Repair: Expanding Horizons. 62
35657303 2022
30
Endovascular repair of a symptomatic aortic dissection with a preloaded t-Branch stent graft. 62
36325312 2022
31
Aortic Dissection. 62
36328623 2022
32
13-year single-center experience with the treatment of acute type B aortic dissection. 62
36184791 2022
33
A reversed strategy for treating type B aortic dissection with open aortoiliac replacement prior to thoracic endovascular aortic repair. 62
36444208 2022
34
Role of False Lumen Area Ratio in Late Aortic Events After Acute Type I Aortic Dissection Repair. 62
35398312 2022
35
The effect of in situ laser fenestration for total endovascular arch repair in redo aortic dissection. 62
34402656 2022
36
Impact of fluid balance and blood transfusion during extracorporeal circulation on outcome for acute type A aortic dissection surgery. 62
35913035 2022
37
Carbon-dioxide-combining-power and postoperative short-term mortality in patients with Stanford type A acute aortic dissection. 62
35760687 2022
38
Transfusion in Root Replacement for Aortic Dissection: The STS Adult Cardiac Surgery Database Analysis. 62
35452664 2022
39
Commentary: A tailored strategy for repair of acute type A aortic dissection: Balancing risk versus benefit. 62
33640127 2022
40
The "Hand as foot" teaching method in the classification of aortic dissection. 62
35697612 2022
41
Reducing Transfusions After Acute Aortic Dissection: Still a Long Way to Go. 62
35513049 2022
42
[Acute Aortic Dissection: A Life-Threatening Disease Also in Neurological Emergency Medicine]. 62
35508194 2022
43
Aortic remodeling after endovascular aortic repair and tailored distal entry tears exclusion in Crawford type III or IV dissection aneurysm. 62
35717417 2022
44
Updates in aortic wall pathology. 62
34845508 2022
45
Rare case of infective aortitis with aortic rupture and cardiac tamponade in a young child. 62
36455981 2022
46
Alpha-lipoic acid protects against aortic aneurysm and dissection by improving vascular smooth muscle cell function. 62
36368416 2022
47
Association of HIV infection with clinical features and outcomes of patients with aortic aneurysms. 62
36190774 2022
48
Intra-arrest transesophageal echocardiography during cardiopulmonary resuscitation. 62
36475353 2022
49
Projection of global burden and risk factors for aortic aneurysm - timely warning for greater emphasis on managing blood pressure. 62
35139697 2022
50
Enhanced burst strength of catechol groups-modified Alaska pollock-derived gelatin-based surgical adhesive. 62
36274395 2022
Sources

Variations for Aortic Dissection

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ClinVar genetic disease variations for Aortic Dissection:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 FBN1 NM_000138.5(FBN1):c.364C>T (p.Arg122Cys) SNV Pathogenic
 16440 rs137854467 GRCh37: 15:48892414-48892414
GRCh38: 15:48600217-48600217
2 LDLR NM_000527.5(LDLR):c.682G>A (p.Glu228Lys) SNV Pathogenic
 3691 GRCh37: 19:11216264-11216264
GRCh38: 19:11105588-11105588
3 FBN1 NM_000138.5(FBN1):c.7274A>G (p.Tyr2425Cys) SNV Likely Pathogenic
 373976 rs1057518809 GRCh37: 15:48717992-48717992
GRCh38: 15:48425795-48425795
4 FBN1 NM_000138.5(FBN1):c.478T>C (p.Cys160Arg) SNV Likely Pathogenic
 374203 rs1057518973 GRCh37: 15:48888540-48888540
GRCh38: 15:48596343-48596343
5 COL3A1 NM_000090.3(COL3A1):c.638_639delinsAA (p.Gly213Glu) INDEL Likely Pathogenic
 492833 rs1553507345 GRCh37: 2:189854123-189854124
GRCh38: 2:188989397-188989398
6 FBN1 NM_000138.5(FBN1):c.6943A>G (p.Thr2315Ala) SNV Uncertain Significance
 689552 rs1597518834 GRCh37: 15:48720597-48720597
GRCh38: 15:48428400-48428400
7 MYLK NM_053025.4(MYLK):c.2149G>A (p.Asp717Asn) SNV Uncertain Significance
 519975 rs150936840 GRCh37: 3:123426842-123426842
GRCh38: 3:123707995-123707995
Sources

Expression for Aortic Dissection

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Search GEO for disease gene expression data for Aortic Dissection.
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Pathways for Aortic Dissection

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Pathways related to Aortic Dissection according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 64
Show member pathways
 13.8 TGFBR1 TGFB3 TGFB2 SMAD3 MYH11 FBN1
2
Signal Transduction 66
13.71 ACTA2 COL3A1 FBN1 MMP2 MMP9 MYH11
3
Integrin Pathway 64
Show member pathways
 13.29 ACTA2 COL3A1 EFEMP2 ELN FBN1 MMP2
4
Phospholipase-C Pathway 64
Show member pathways
 13.04 TGFBR1 TGFB3 TGFB2 FBN1 ELN EFEMP2
5
Sertoli-Sertoli Cell Junction Dynamics 64
Show member pathways
 12.91 TGFBR1 TGFB3 TGFB2 PRKG1 MYH11 ACTA2
6
Toll-like receptor signaling pathway 74
Show member pathways
 12.8 TGFBR1 TGFB3 TGFB2 SMAD3 MMP9
7
Extracellular matrix organization 66
Show member pathways
 12.5 COL3A1 EFEMP2 ELN FBLN5 FBN1 LOX
8
Human Embryonic Stem Cell Pluripotency 64
Show member pathways
 12.42 TGFBR1 TGFB3 TGFB2 SMAD3
9
Signaling by TGFB family members 66
Show member pathways
 12.41 TGFBR1 TGFB3 TGFB2 SMAD3 FBN1
10
Cell cycle Regulation of G1/S transition (part 1) 22
Show member pathways
 12.33 TGFBR1 TGFB3 TGFB2 SMAD3
11
Wnt / Hedgehog / Notch 3
12.22 TGFBR1 TGFB3 TGFB2 SMAD3
12
ECM proteoglycans 66
Show member pathways
 12.17 TGFB3 TGFB2 FBN1 COL3A1
13
Colorectal Cancer Metastasis 64
12.15 TGFBR1 TGFB3 TGFB2 SMAD3 MMP9 MMP2
14
Epithelial to mesenchymal transition in colorectal cancer 74
12.12 TGFBR1 TGFB3 TGFB2 SMAD3 MMP9 MMP2
15
Neuroinflammation and glutamatergic signaling 74
12.08 TGFBR1 TGFB3 TGFB2 SMAD3
16
TGF-beta receptor signaling activates SMADs 66
Show member pathways
 11.92 TGFBR1 TGFB3 TGFB2 SMAD3 FBN1
17
TGF-beta Signaling Pathways 65
11.88 TGFBR1 TGFB3 TGFB2 SMAD3
18
Th17 Differentiation 65
Show member pathways
 11.85 TGFBR1 TGFB3 TGFB2 SMAD3
19
CCL18 signaling pathway 74
11.84 SMAD3 MMP2 ACTA2
20
Angiogenesis (CST) 3
11.84 MMP2 MMP9 TGFB2 TGFB3 TGFBR1
21
Mesenchymal Stem Cells and Lineage-specific Markers 65
11.83 TGFB3 TGFB2 ACTA2
22
7q11.23 copy number variation syndrome 74
11.81 PRKG1 FBN1 FBLN5 ELN
23
Transcription_P53 signaling pathway 22
11.69 TGFBR1 TGFB3 TGFB2 SMAD3 MMP2 ACTA2
24
Lung fibrosis 74
11.64 MMP9 MMP2 ELN
25
Cell adhesion_ECM remodeling 22
11.62 COL3A1 MMP2 MMP9
26
IL-2 Gene Expression in Activated and Quiescent T-Cells 64
Show member pathways
 11.54 TGFBR1 TGFB3 TGFB2 SMAD3 MMP9 MMP2
27
TGF-beta receptor signaling 61
11.53 TGFBR1 TGFB3 SMAD3
28
NRP1-triggered signaling pathways in pancreatic cancer 74
11.46 TGFBR1 TGFB3 TGFB2 SMAD3 MMP9 MMP2
29
Elastic fibre formation 66
Show member pathways
 11.41 TGFB3 TGFB2 LOX FBN1 FBLN5 ELN
30
A-beta Uptake and Degradation 65
11.34 MMP9 MMP2 LDLR ACE
31
Extracellular vesicle-mediated signaling in recipient cells 74
11.26 TGFBR1 TGFB3 TGFB2 SMAD3
32
Angiotensin II receptor type 1 pathway 74
11.25 TGFBR1 SMAD3 ACTA2
33
Neovascularisation processes 74
11.25 TGFBR1 TGFB3 TGFB2 SMAD3 MMP9
34
Hypothesized pathways in pathogenesis of cardiovascular disease 74
11.19 TGFBR1 SMAD3 FBN1
35
A-beta Plaque Formation and APP Metabolism 65
11.14 ACE MMP2 MMP9
36
Burn wound healing 74
11.1 TGFB3 TGFB2 TAGLN SMAD3 MMP9 MMP2
37
G-protein signaling_Rap2B regulation pathway 22
11.01 COL3A1 EFEMP2 ELN FBN1 TGFB2 TGFB3
38
IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types 65
10.98 TGFBR1 TGFB3 TGFB2
39
Canonical and non-canonical TGF-B signaling 74
10.97 TGFBR1 SMAD3 LOX
40
IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types 65
10.75 TGFB3 TGFB2
Sources

GO Terms for Aortic Dissection

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Cellular components related to Aortic Dissection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.4 TGFB3 TGFB2 MMP9 MMP2 LOX FBN1
2 extracellular space GO:0005615 10.32 ACE ACTA2 COL3A1 CRP EFEMP2 FBLN5
3 extracellular matrix GO:0031012 9.77 COL3A1 EFEMP2 ELN FBLN5 FBN1 LOX
4 elastic fiber GO:0071953 9.63 FBLN5 ELN EFEMP2
5 collagen-containing extracellular matrix GO:0062023 9.62 TGFB3 TGFB2 MMP9 MMP2 LOX FBN1

Biological processes related to Aortic Dissection according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 10.26 TGFBR1 TGFB3 MMP9 MMP2 ACE
2 response to hypoxia GO:0001666 10.16 ACE MMP2 SMAD3 TGFB2 TGFB3
3 kidney development GO:0001822 10.13 TGFBR1 TGFB2 FBN1 ACE
4 heart development GO:0007507 10.1 COL3A1 FBN1 LOX MMP2 TGFB2 TGFBR1
5 positive regulation of stress fiber assembly GO:0051496 10.09 TGFBR1 TGFB3 SMAD3
6 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 10.08 TGFBR1 TGFB3 TGFB2
7 skeletal system development GO:0001501 10.06 TGFBR1 TGFB2 SMAD3 MMP9 FBN1
8 negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 10.03 TGFB3 PRKG1 EFEMP2
9 collagen fibril organization GO:0030199 10.03 TGFBR1 TGFB2 LOX COL3A1
10 cell-cell junction organization GO:0045216 9.97 TGFB3 TGFB2 SMAD3
11 positive regulation of epithelial to mesenchymal transition GO:0010718 9.97 TGFBR1 TGFB3 TGFB2 SMAD3
12 transforming growth factor beta receptor signaling pathway GO:0007179 9.96 TGFBR1 TGFB3 TGFB2 SMAD3 COL3A1
13 salivary gland morphogenesis GO:0007435 9.92 TGFB3 TGFB2
14 response to laminar fluid shear stress GO:0034616 9.89 TGFB3 ACE
15 regulation of striated muscle tissue development GO:0016202 9.88 LOX SMAD3
16 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.87 TGFB2 TGFBR1
17 angiogenesis involved in coronary vascular morphogenesis GO:0060978 9.85 TGFBR1 ACE
18 regulation of transforming growth factor beta2 production GO:0032909 9.84 TGFB2 SMAD3
19 positive regulation of tight junction disassembly GO:1905075 9.83 TGFB3 TGFBR1
20 aorta development GO:0035904 9.81 LOX EFEMP2 COL3A1
21 uterine wall breakdown GO:0042704 9.78 TGFB3 TGFB2
22 wound healing GO:0042060 9.73 COL3A1 LOX SMAD3 TGFB2 TGFB3 TGFBR1
23 aorta smooth muscle tissue morphogenesis GO:0060414 9.55 MIR145 EFEMP2 COL3A1
24 elastic fiber assembly GO:0048251 9.32 MYH11 LOX FBLN5 EFEMP2 COL3A1

Molecular functions related to Aortic Dissection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.92 FBN1 ELN EFEMP2 COL3A1
2 SMAD binding GO:0046332 9.77 TGFBR1 SMAD3 COL3A1
3 type III transforming growth factor beta receptor binding GO:0034714 9.56 TGFB3 TGFB2
4 transforming growth factor beta receptor binding GO:0005160 9.55 TGFB3 TGFB2 SMAD3
5 type II transforming growth factor beta receptor binding GO:0005114 9.43 TGFBR1 TGFB3 TGFB2
6 extracellular matrix constituent conferring elasticity GO:0030023 9.1 FBN1 FBLN5 ELN
Sources

Sources for Aortic Dissection

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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