MCID: ART074
MIFTS: 52

Aortic Dissection

Categories: Cardiovascular diseases

Aliases & Classifications for Aortic Dissection

MalaCards integrated aliases for Aortic Dissection:

Name: Aortic Dissection 12 74 54 6

Classifications:



External Ids:

Disease Ontology 12 DOID:0080685

Summaries for Aortic Dissection

Disease Ontology : 12 An aortic disease that is characterized by tearing of the intimal layer of the aorta resulting in seperation of the layers of the aeortic wall.

MalaCards based summary : Aortic Dissection is related to aortic aneurysm, familial thoracic 4 and brittle bone disorder. An important gene associated with Aortic Dissection is FBN1 (Fibrillin 1), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Ticagrelor and Cangrelor have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and smooth muscle, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 74 Aortic dissection (AD) occurs when an injury to the innermost layer of the aorta allows blood to flow... more...

Related Diseases for Aortic Dissection

Diseases related to Aortic Dissection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 604)
# Related Disease Score Top Affiliating Genes
1 aortic aneurysm, familial thoracic 4 33.5 NDE1 MYH11
2 brittle bone disorder 32.1 FBN1 ELN COL5A2 COL3A1
3 loeys-dietz syndrome 5 31.6 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 FBN1
4 ehlers-danlos syndrome 31.6 TGFBR1 MYH11 FBN1 ELN COL5A2 COL3A1
5 loeys-dietz syndrome 4 31.4 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 FBN1
6 aortic valve insufficiency 30.7 TGFBR2 TGFBR1 MYH11 FBN1 ELN ACTA2
7 marfan syndrome 30.4 TGFBR2 TGFBR1 TGFB2 MYH11 LOX FBN1
8 carotid artery dissection 30.3 LDLR COL3A1
9 ehlers-danlos syndrome, vascular type 30.1 ELN COL3A1
10 pectus carinatum 29.9 FBN1 COL5A2
11 aortic aneurysm, familial thoracic 6 29.8 TGFBR1 NDE1 MYH11 ACTA2
12 moyamoya disease 1 29.8 MYH11 ELN ACTA2
13 tracheal stenosis 29.8 TGFB3 FBN1
14 patent ductus arteriosus 1 29.7 TGFBR2 TGFBR1 MYH11 FBN1 ELN ACTA2
15 pseudoxanthoma elasticum 29.7 MYH11 FBN1 ELN
16 hypermobility syndrome 29.7 FBN1 COL5A2 COL3A1
17 tetralogy of fallot 29.6 SMAD4 MYH11 FBN1 ELN
18 familial thoracic aortic aneurysm and aortic dissection 29.6 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
19 varicose veins 29.5 FBN1 ELN COL3A1
20 supravalvular aortic stenosis 29.5 LDLR FBN1 ELN
21 inguinal hernia 29.4 LOX FBN1 ELN
22 mitral valve disease 29.4 TGFB3 TGFB2 FBN1 ELN
23 arteriosclerosis 29.2 LOX LDLR FBN1 ELN
24 aortic aneurysm, familial thoracic 1 29.0 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
25 pulmonary hypertension 28.8 TGFBR2 TGFBR1 SMAD4 SMAD3 PRKG1 ACTA2
26 scoliosis 28.8 TGFBR2 TGFB2 LOX FBN1 ELN
27 loeys-dietz syndrome 28.8 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
28 pancreatic adenocarcinoma 28.5 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
29 intracranial aneurysm 28.5 TGFBR2 TGFBR1 TGFB2 LOX ELN COL3A1
30 collagen disease 28.4 TGFBR2 TGFBR1 FBN1 ELN COL5A2 COL3A1
31 loeys-dietz syndrome 1 28.3 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 MYH11
32 hypertension, essential 28.0 SMAD3 PRKG1 LOX LDLR FBN1 ELN
33 heart disease 27.9 TGFB3 SMAD4 LDLR FBN1 ELN ACTA2
34 aortic aneurysm 27.6 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
35 aneurysm 27.4 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
36 aortic disease 27.3 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
37 orthostatic intolerance 27.2 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 MYH11
38 heritable thoracic aortic disease 27.1 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
39 connective tissue disease 27.0 TGFBR2 TGFBR1 TGFB2 SMAD3 PRKG1 NDE1
40 aortic valve disease 1 26.6 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
41 aortic dissection lentiginosis 12.4
42 rare disease with thoracic aortic aneurysm and aortic dissection 12.4
43 aortic aneurysm, familial thoracic 7 11.9
44 temporal arteritis 11.7
45 aortic aneurysm, familial thoracic 9 11.6
46 aortic aneurysm, familial thoracic 10 11.6
47 cystic medial necrosis of aorta 11.5
48 meester-loeys syndrome 11.3
49 cole-carpenter syndrome 11.3
50 vascular myelopathy 11.3

Graphical network of the top 20 diseases related to Aortic Dissection:



Diseases related to Aortic Dissection

Symptoms & Phenotypes for Aortic Dissection

GenomeRNAi Phenotypes related to Aortic Dissection according to GeneCards Suite gene sharing:

26 (show top 50) (show all 58)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 10.05 TGFBR2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-107 10.05 TGFB2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-121 10.05 TGFBR2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-123 10.05 TGFBR2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-133 10.05 TGFB2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 10.05 TGFB2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 10.05 TGFBR2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-152 10.05 TGFBR2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 10.05 TGFBR2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-164 10.05 TGFBR2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 10.05 TGFBR1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 10.05 TGFBR1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-182 10.05 PRKG1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 10.05 TGFBR2
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-208 10.05 PRKG1
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-214 10.05 TGFBR2
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 10.05 TGFB2
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-36 10.05 TGFBR1
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-50 10.05 TGFB2
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 10.05 TGFBR2
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 10.05 TGFB2
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-73 10.05 TGFBR2
23 Decreased shRNA abundance (Z-score < -2) GR00366-A-81 10.05 TGFBR2
24 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 10.05 TGFBR2
25 Decreased shRNA abundance (Z-score < -2) GR00366-A-88 10.05 PRKG1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.91 SMAD4
27 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.91 SMAD4 TGFB2 TGFBR1 TGFBR2
28 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.91 TGFB2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.91 TGFBR2
30 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.91 TGFBR2
31 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.91 TGFB2
32 Increased shRNA abundance (Z-score > 2) GR00366-A-14 9.91 TGFB2
33 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.91 TGFBR1 TGFBR2
34 Increased shRNA abundance (Z-score > 2) GR00366-A-162 9.91 TGFBR2
35 Increased shRNA abundance (Z-score > 2) GR00366-A-165 9.91 TGFBR2
36 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.91 TGFBR1
37 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.91 TGFBR2
38 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.91 TGFBR2
39 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.91 SMAD4
40 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.91 TGFB2
41 Increased shRNA abundance (Z-score > 2) GR00366-A-200 9.91 TGFBR1
42 Increased shRNA abundance (Z-score > 2) GR00366-A-212 9.91 SMAD4
43 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.91 TGFB2
44 Increased shRNA abundance (Z-score > 2) GR00366-A-22 9.91 TGFBR1
45 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.91 SMAD4
46 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.91 TGFBR1
47 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.91 TGFBR2
48 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.91 TGFB2
49 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.91 SMAD4
50 Increased shRNA abundance (Z-score > 2) GR00366-A-48 9.91 TGFBR2

MGI Mouse Phenotypes related to Aortic Dissection:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.4 ACTA2 COL3A1 COL5A2 FBN1 LDLR LOX
2 cellular MP:0005384 10.33 COL3A1 FBN1 LDLR MYH11 NDE1 PRKG1
3 growth/size/body region MP:0005378 10.24 COL3A1 COL5A2 FBN1 LDLR MYH11 SMAD3
4 homeostasis/metabolism MP:0005376 10.23 COL3A1 FBN1 LDLR LOX MYH11 PRKG1
5 digestive/alimentary MP:0005381 10.22 COL3A1 LDLR MYH11 PRKG1 SMAD3 SMAD4
6 hematopoietic system MP:0005397 10.22 COL3A1 FBN1 LDLR LOX PRKG1 SMAD3
7 mortality/aging MP:0010768 10.18 COL3A1 COL5A2 FBN1 LDLR LOX MYH11
8 immune system MP:0005387 10.17 COL3A1 FBN1 LDLR LOX PRKG1 SMAD3
9 embryo MP:0005380 10.11 FBN1 NDE1 SMAD3 SMAD4 TGFB2 TGFB3
10 integument MP:0010771 10.1 COL3A1 COL5A2 FBN1 LDLR LOX MYH11
11 muscle MP:0005369 10.06 ACTA2 COL3A1 FBN1 LDLR LOX MYH11
12 craniofacial MP:0005382 10.01 FBN1 SMAD3 SMAD4 TGFB2 TGFB3 TGFBR2
13 nervous system MP:0003631 9.96 FBN1 LDLR NDE1 PRKG1 SMAD3 SMAD4
14 renal/urinary system MP:0005367 9.7 FBN1 MYH11 PRKG1 SMAD3 SMAD4 TGFB2
15 respiratory system MP:0005388 9.61 COL3A1 COL5A2 FBN1 LOX MYH11 TGFB2
16 skeleton MP:0005390 9.28 COL5A2 FBN1 LOX SMAD3 SMAD4 TGFB2

Drugs & Therapeutics for Aortic Dissection

Drugs for Aortic Dissection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 121)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ticagrelor Approved Phase 4 274693-27-5 9871419
2
Cangrelor Approved Phase 4 163706-06-7 9854012
3
Bivalirudin Approved, Investigational Phase 4 128270-60-0 16129704
4
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
5
Verapamil Approved Phase 4 52-53-9 2520
6
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
7
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
8
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
9
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
10
Tenecteplase Approved Phase 4 191588-94-0
11
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
12 polysaccharide-K Phase 4
13 Anesthetics Phase 4
14 Anesthetics, General Phase 4
15
protease inhibitors Phase 4
16 HIV Protease Inhibitors Phase 4
17 Vasodilator Agents Phase 4
18 Angiotensin-Converting Enzyme Inhibitors Phase 4
19 Antigen-Antibody Complex Phase 4
20 Pharmaceutical Solutions Phase 4
21 Hypnotics and Sedatives Phase 4
22 Anesthetics, Intravenous Phase 4
23 Neurotransmitter Agents Phase 4
24 calcium heparin Phase 4
25 Purinergic P2Y Receptor Antagonists Phase 4
26 Platelet Aggregation Inhibitors Phase 4
27 Fibrinolytic Agents Phase 4
28
Angiotensin II Approved, Investigational Phase 3 4474-91-3, 11128-99-7, 68521-88-0 172198
29
Atenolol Approved Phase 3 29122-68-7 2249
30
Telmisartan Approved, Investigational Phase 3 144701-48-4 65999
31 Hemostatics Phase 2, Phase 3
32 Adrenergic beta-Antagonists Phase 3
33 Angiotensinogen Phase 3
34 Angiotensin Receptor Antagonists Phase 3
35 Giapreza Phase 3
36 Adrenergic Antagonists Phase 3
37 Adrenergic Agents Phase 3
38 Adrenergic beta-1 Receptor Antagonists Phase 3
39 Anti-Arrhythmia Agents Phase 3
40 Sympatholytics Phase 3
41 Angiotensin II Type 1 Receptor Blockers Phase 3
42
Propranolol Approved, Investigational Phase 2 525-66-6 4946
43
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
44
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
45
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
46
Bevacizumab Approved, Investigational Phase 2 216974-75-3
47 Protamines Phase 2
48 Immunoglobulins Phase 2
49 Antibodies Phase 2
50 Endothelial Growth Factors Phase 2

Interventional clinical trials:

(show top 50) (show all 157)
# Name Status NCT ID Phase Drugs
1 Cangrelor vs. Ticagrelor for Early Platelet Inhibition in ST-elevation Myocardial Infarction Unknown status NCT03182855 Phase 4 Ticagrelor;Cangrelor Tetrasodium
2 Effects of Atenolol, Perindopril and Verapamil on Haemodynamic and Vascular Function in Marfan Syndrome - A Randomised Double-Blind Crossover Trial Completed NCT01295047 Phase 4 Atenolol;VERAPAMIL;Perindopril
3 A Trial of Telmisartan Prevention of Cardiovascular Disease Completed NCT01075698 Phase 4 Non-ARB (standard therapy);ARB (Telmisartan)
4 Diagnostic Value of Comprehensive Cardiothoracic Dual Source CT for the Early Triage of Patients With Undifferentiated Acute Chest Pain Completed NCT01067456 Phase 4
5 Effects of OctaplasLG® on Endothelial Integrity in Patients Undergoing Emergency Surgery for Thoracic Aortic Dissections - a Randomized, Controlled, Single-blinded Investigator-initiated Pilot Trial Completed NCT02253082 Phase 4 OctaplasLG®
6 Randomized Trial of Pulsatile vs Non Pulsatile Perfusion on Short Term Changes in Kidney Function Using an Intra-Aortic Ballooon Pump During Cardioplegic Arrest in Patients Undergoing Myocardial Reperfusion Completed NCT00454428 Phase 4
7 EFFICACY OF KETAMINE-PROPOFOL COMBINATION FOR SHORT SURGICAL PROCEDURES Completed NCT01651988 Phase 4 Ketamina-Propofol Combination
8 Long-term Benefit of Aortic Stent-graft in Patients With Distal Aortic Dissection Terminated NCT01354119 Phase 4
9 A Safety and Efficacy Study of Blood Pressure Control in Acute Aortic Emergencies - A Pilot Study (PROMPT) Terminated NCT01033370 Phase 4 clevidipine.
10 TRIANA: A Randomized Trial to Compare the Efficay and Safety of Thrombolysis With Primary Angioplasty as Initial Reperfusion Therapy in Older Patients (>= 75 Years Old) With Acute Myocardial Infarction Terminated NCT00257309 Phase 4 Tenecteplase + UFH (+ clopidogrel, since 01/97)
11 Extensive Type A Dissections and Thoracic/ Thoraco-Abdominal Withdrawn NCT01107366 Phase 4
12 The Efficacy and Safety of Cleviprex in Ventriculostomy Patients Requiring IV Antihypertensive Therapy Investigator Initiated Trial Withdrawn NCT01042574 Phase 4 Clevidipine butyrate
13 A Randomized Comparison of Strategies for Type B Aortic Dissection - the INvestigation of STEnt-grafts in Aortic Dissection (INSTEAD) Trial Completed NCT01415804 Phase 2, Phase 3
14 INvestigation of STEnt Grafts in Patients With Type B Aortic Dissection Completed NCT00525356 Phase 3
15 The Hemostatic Potential of TDM-621 on Ascending Aortic Surgery Recruiting NCT03917862 Phase 2, Phase 3
16 Multicenter, Randomised, Double Blind Study of the Efficacy of Losartan on Aortic Dilatation in Patients With Marfan Syndrome Terminated NCT00763893 Phase 3 placebo;Losartan
17 Beta Blockers and Angiotensin Receptor Blockers in Bicuspid Aortic Valve Disease Aortopathy (BAV Study) Terminated NCT01202721 Phase 3 Atenolol;Telmisartan
18 Circulating Transforming Growth Factor Beta (TGF-β) in Individuals With Withdrawn NCT01361087 Phase 3
19 Safety and Efficacy of Fibrinogen Concentrate in Aortic Arch Surgery Involving Moderate Hypothermic Circulatory Arrest Unknown status NCT02542306 Phase 2 fibrinogen concentrate
20 A Randomized, Open-label, Active Control Trial to Evaluate the Effect of LOSARTAN Therapy on the Progression of Aortic Root Dilation in Patients With Marfan Syndrome Unknown status NCT00651235 Phase 2 Losartan and Atenolol or Propranolol;Atenolol or Propranolol
21 A Phase II Trial of a Vascular Endothelial Growth Factor (VEGF) Monoclonal Antibody, AVASTIN, in Combination With Cytotoxic Chemotherapy CARBOPLATIN and PACLITAXEL for Recurrent/Advanced Endometrial Cancer Completed NCT00879359 Phase 2 carboplatin, paclitaxel, and bevacizumab
22 Prognostic of Annexin Imaging in Dissection of the Descending Aorta Not yet recruiting NCT03832582 Phase 2 Annexin
23 A Phase II Study of Combined VEGF Inhibitor (Bevacizumab + Sorafenib) in Patients With Metastatic Breast Cancer: Hoosier Oncology Group BRE06-109 Terminated NCT00632541 Phase 2 Sorafenib;Bevacizumab
24 Intensive Blood PRessure Control in Patients With Acute Type B AortIc Dissection (RAID): Study Protocol for Randomized Controlled Trial Unknown status NCT03001739 Phase 1 Urapidil Hydrochloride Injection
25 Clinical Investigation of Chinese Patients With Aortic Dissection Unknown status NCT01552720
26 Superiority Trial of Type b Aortic Dissection Treatment Combined With Implantation of Bare Metal Stent in Abdominal Part of Aorta Versus Conventional Type b Treatment Unknown status NCT02726841
27 Comparison of the Effects of Open and Endovascular Aortic Aneurysm Repair on Long-term Renal Function Unknown status NCT02220283
28 A Single-center Trial of Patients With Aortic Dissection in the Chinese XinJiang Province Unknown status NCT02378103
29 The Role of Thyroid Function in the Development and Prognosis of Stanford Type A Aortic Dissection. Unknown status NCT03146494
30 Protection of Xenon Against Postoperative Oxygen Impairment in Adults Undergoing Stanford Type-A Acute Aortic Dissection Surgery Unknown status NCT02468531 Xenon
31 Mechanism and Early Intervention Research on Acute Lung Injury During Emergence Surgery of Acute Stanford A Aortic Dissection Unknown status NCT01894334 Ulinastatin;Tranexamic acid;Edaravone
32 Cerebral and Spinal Protection of Xenon Post-conditioning in Patients Undergoing Aortic Dissection Repair Unknown status NCT02774096 xenon
33 A Multi-center Trial of Castor Single-Branched Stent Graft System for Endovascular Repair of Aortic Dissection. Unknown status NCT01914237
34 Exploratory Study of Prognostic Factors in Aortic Dissection Type B: Role of Imaging (18F-FDG PET-Scan and Angioscan) and Biomarkers Unknown status NCT01984905
35 Potential Biomarkers for Early Diagnosis of Acute Aortic Dissection Unknown status NCT01860768
36 Prognostic Value of Single-dose Glucocorticoid After Endovascular Repair for Aortic Dissection Unknown status NCT02523300 Glucocorticoids;saline
37 Retrospective Study of Acute Chest Pain in Extremely Critical Condition for More Than Ten Years Unknown status NCT02837120
38 Significance of Serum Tenascin C in Patients With Acute Aortic Disease Unknown status NCT02816892
39 Mechanical Characterization of Ascending Aorta in Patients With Acute Type A Dissection and in Healthy Control Group Combined to Structural and Ultrastructural Analysis of Aortic Tissue Unknown status NCT02860182
40 My Research Legacy Pilot Study Unknown status NCT02958098
41 Diagnostic Accuracy and Clinic Utility of Bedside Ultrasonography Performed by Emergency Physicians in Suspected Acute Appendicitis Unknown status NCT02467959
42 Salvage Treatment of Inhaled Nitric Oxide in Patients With Refractory Hypoxemia After Aortic Surgery Unknown status NCT03009643 Inhaled Nitric Oxide
43 Blood Pressure Control and Arterial Properties After Surgical Treatment of Type A Thoracic Aortic Dissection or Haematoma Unknown status NCT01068691
44 Triple-branch Stent Graft Placement and Total-arch Replacement for the Treatment of Acute DeBakey I Aortic Dissection: A Prospective, Multi-center, Randomized, Open-label, Parallel-group, Non-inferiority Clinical Trial Unknown status NCT02622750 Early Phase 1
45 Transient ECG Changes in Patients With Acute Biliary Disease Unknown status NCT01706068
46 Endovascular Aortic Repair for Aortic Dissection------XiJing Registry Unknown status NCT01505309
47 Prospective Characterization of the Heart, Aorta and Blood Pressure in Women With Turner Syndrome. Association With Aortic Dissection. Unknown status NCT01678274
48 Hybrid Operation in Thoracic Aortic Dissection---Registry of China Unknown status NCT01500395
49 Clinical Study on Evaluation of Total Endovascular Aortic Arch Repair Unknown status NCT03347812
50 The Italian Society of Invasive Cardiology Registry on Percutaneous Aortic Valve Unknown status NCT02713932

Search NIH Clinical Center for Aortic Dissection

Genetic Tests for Aortic Dissection

Anatomical Context for Aortic Dissection

MalaCards organs/tissues related to Aortic Dissection:

40
Heart, Kidney, Smooth Muscle, Lung, Spinal Cord, Brain, Testes

Publications for Aortic Dissection

Articles related to Aortic Dissection:

(show top 50) (show all 12706)
# Title Authors PMID Year
1
FBN1 mutations in patients with descending thoracic aortic dissections. 54 61
20082464 2010
2
Comparison of clinical presentations and outcomes between patients with TGFBR2 and FBN1 mutations in Marfan syndrome and related disorders. 61 54
19996017 2009
3
Soluble elastin decreases in the progress of atheroma formation in human aorta. 54 61
19755752 2009
4
Comparison of computed radiography and multi-detector computed tomography in the detection of post mortem metacarpal index. 61 54
18353575 2008
5
[Aortic dissection]. 54 61
18413993 2008
6
What's new in the biochemical diagnosis of acute aortic dissection: problems and perspectives. 61 54
17660735 2007
7
Functional promoter polymorphism in the VKORC1 gene is no major genetic determinant for coronary heart disease in Northern Germans. 54 61
17549303 2007
8
Gene expression in acute Stanford type A dissection: a comparative microarray study. 61 54
16824202 2006
9
VKORC1 haplotypes are associated with arterial vascular diseases (stroke, coronary heart disease, and aortic dissection). 54 61
16549638 2006
10
Marfan syndrome: what internists and pediatric or adult cardiologists need to know. 54 61
16181034 2005
11
Decreased expression of fibulin-5 correlates with reduced elastin in thoracic aortic dissection. 61 54
16153447 2005
12
Coexistent aortic dissection and hepatocellular carcinoma with elevated plasma transforming growth factor beta level: possible roles of fibrillin 1 and transforming growth factor beta. 54 61
15678071 2005
13
[Soluble elastin fragments in serum are elevated in aortic dissection]. 61 54
15046049 2004
14
Diagnostic implications of elevated levels of smooth-muscle myosin heavy-chain protein in acute aortic dissection. The smooth muscle myosin heavy chain study. 54 61
11015167 2000
15
Collagen and elastin degradation by matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase in aortic dissection. 61 54
10872655 2000
16
Intracoronary serum smooth muscle myosin heavy chain levels following PTCA may predict restenosis. 54 61
10850529 2000
17
Biochemical diagnosis of aortic dissection: from bench to bedside. 54 61
10888373 1999
18
[Increased serum concentration of myosin heavy chain in aortic dissection: discussion of 2 cases]. 61 54
9324878 1997
19
Novel biochemical diagnostic method for aortic dissection. Results of a prospective study using an immunoassay of smooth muscle myosin heavy chain. 54 61
8653847 1996
20
An 82-year-old female with chest pain radiating to the back and flank. 61
32420036 2020
21
Targeted depletion of monocyte/macrophage suppresses aortic dissection with the spatial regulation of MMP-9 in the aorta. 61
31672577 2020
22
Preclinical evaluation of an endovascular sealing device for distal re-entry tears in type B aortic dissection in a porcine model. 61
32305561 2020
23
Early Screening for Aortic Dissection With Point-of-Care Ultrasound by Emergency Physicians: A Prospective Pilot Study. 61
31971274 2020
24
Long-term Results of Endovascular Treatment of Chronic Type B Aortic Dissection by Closure of the Primary Tear. 61
31629855 2020
25
Decreased Abdominal Aortic Aneurysm Size Following EVAR in Patients With CT Evidence of Subclinical Thoracic Aortic Dissection. 61
31706995 2020
26
Impact of histopathological changes in ascending aortic diseases. 61
32331910 2020
27
Readmissions after acute type B aortic dissection. 61
31839347 2020
28
Total arch replacement and frozen elephant trunk for aortic dissection in aberrant right subclavian artery. 61
32057078 2020
29
Open descending aortic replacement in a patient with a fractured Djumbodis™ dissection system. 61
31958114 2020
30
Spinal Cord Ischemia Rescue after Hybrid Total Arch Repair with Frozen Elephant Trunk: A Case Report. 61
32032702 2020
31
Acute Aortic Syndromes: Diagnostic and Therapeutic Pathways. 61
32503754 2020
32
Successful treatment of spontaneous middle mediastinum hematoma due to rupture of bilateral bronchial artery with transcatheter arterial embolization using N-butyl-2-cyanoacrylate: A case report. 61
32426082 2020
33
Imaging Cardiovascular Emergencies: Real World Clinical Cases. 61
32503756 2020
34
Impact of Supraaortic Intimal Tears on Aortic Diameter Changes After Nontotal Arch Replacement. 61
31846644 2020
35
Neurologic complications after the frozen elephant trunk procedure: A meta-analysis of more than 3000 patients. 61
31757456 2020
36
Stanford Type A, Debakey Type I Aortic Dissection Involving the Internal Carotid and Femoral Arteries Presenting as Left Middle Cerebral Artery Acute Ischemic Stroke. 61
32549951 2020
37
Impact of center volume on outcomes of surgical repair for type A acute aortic dissections. 61
32507629 2020
38
Discussions in Cardiothoracic Treatment and Care: The Contemporary Management of Acute Type A Aortic Dissection. 61
32061659 2020
39
Surgical Management and Outcomes of the Aortic Root in Acute Type A Aortic Dissection. 61
31783019 2020
40
Aortic Remodeling After Extended PETTICOAT Technique in Acute Aortic Dissection Type III B. 61
31669476 2020
41
Meteorological and chronobiological factors and the occurrence of acute aortic dissection. 61
32108242 2020
42
Short- and long-term outcomes in isolated penetrating aortic ulcer disease. 61
32089340 2020
43
Is previous cardiac surgery a risk factor for open repair of acute type A aortic dissection? 61
31585754 2020
44
Identification of clinically relevant variants by whole exome sequencing in Chinese patients with sporadic non-syndromic type A aortic dissection. 61
32209317 2020
45
Aortic arch geometry predicts outcome in patients with Loeys-Dietz syndrome independent of the causative gene. 61
32352226 2020
46
[Late occurrence of pulmonary embolsim in SARS-CoV-2 pneumonia: a case series]. 61
32555568 2020
47
Immediate Surgery in Acute Type A Dissection and Neurologic Dysfunction: Fighting the Inevitable? 61
32114042 2020
48
MiR-26b Suppresses the Development of Stanford Type A Aortic Dissection by Regulating HMGA2 and TGF-β/Smad3 Signaling Pathway. 61
31723084 2020
49
Long-term Results of Thoracic Endovascular Aortic Repair for Type B Aortic Dissection and Risk Factors for Survival. 61
32166999 2020
50
Surgical Decision Making in Uncomplicated Type B Aortic Dissection: A Survey of Australian/New Zealand and European Surgeons. 61
32571654 2020

Variations for Aortic Dissection

ClinVar genetic disease variations for Aortic Dissection:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 FBN1 NM_000138.4(FBN1):c.364C>T (p.Arg122Cys)SNV Pathogenic 16440 rs137854467 15:48892414-48892414 15:48600217-48600217
2 LDLR NM_000527.5(LDLR):c.682G>A (p.Glu228Lys)SNV Pathogenic/Likely pathogenic 3691 rs121908029 19:11216264-11216264 19:11105588-11105588
3 FBN1 NM_000138.4(FBN1):c.7274A>G (p.Tyr2425Cys)SNV Likely pathogenic 373976 rs1057518809 15:48717992-48717992 15:48425795-48425795
4 FBN1 NM_000138.4(FBN1):c.478T>C (p.Cys160Arg)SNV Likely pathogenic 374203 rs1057518973 15:48888540-48888540 15:48596343-48596343
5 COL3A1 NM_000090.3(COL3A1):c.638_639delinsAA (p.Gly213Glu)indel Likely pathogenic 492833 rs1553507345 2:189854123-189854124 2:188989397-188989398
6 MYLK NM_053025.4(MYLK):c.2149G>A (p.Asp717Asn)SNV Uncertain significance 519975 rs150936840 3:123426842-123426842 3:123707995-123707995
7 FBN1 NM_000138.4(FBN1):c.6943A>G (p.Thr2315Ala)SNV Uncertain significance 689552 15:48720597-48720597 15:48428400-48428400

Expression for Aortic Dissection

Search GEO for disease gene expression data for Aortic Dissection.

Pathways for Aortic Dissection

Pathways related to Aortic Dissection according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
2
Show member pathways
13.42 TGFBR2 TGFBR1 TGFB3 TGFB2 MYH11 FBN1
3
Show member pathways
13.33 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
4
Show member pathways
13.1 TGFBR1 TGFB3 TGFB2 FBN1 ELN COL5A2
5
Show member pathways
13.09 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
6
Show member pathways
12.96 TGFBR2 TGFBR1 TGFB3 TGFB2 PRKG1 MYH11
7
Show member pathways
12.91 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
8 12.87 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
9
Show member pathways
12.84 TGFBR2 TGFBR1 TGFB3 TGFB2 ACTA2
10
Show member pathways
12.81 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
11
Show member pathways
12.8 TGFB3 TGFB2 LOX FBN1 ELN COL5A2
12
Show member pathways
12.64 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
13
Show member pathways
12.62 TGFBR2 TGFBR1 COL3A1 ACTA2
14
Show member pathways
12.53 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
15 12.41 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
16 12.4 TGFBR2 TGFBR1 SMAD3 LDLR
17 12.36 TGFB3 TGFB2 SMAD4 SMAD3
18
Show member pathways
12.3 TGFBR2 TGFBR1 SMAD4 SMAD3
19 12.3 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
20
Show member pathways
12.28 TGFBR2 TGFBR1 TGFB2 SMAD4 SMAD3
21 12.23 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
22 12.21 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
23 12.18 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
24 12.13 TGFBR1 SMAD4 SMAD3 ACTA2
25 12.11 TGFBR2 TGFBR1 SMAD4 SMAD3
26
Show member pathways
12.09 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
27 12 TGFBR2 TGFBR1 TGFB2
28 11.95 SMAD4 SMAD3 LDLR
29
Show member pathways
11.94 TGFBR2 TGFBR1 SMAD4 SMAD3
30 11.92 SMAD4 SMAD3 COL3A1
31 11.9 TGFB3 TGFB2 COL3A1
32 11.86 TGFB3 TGFB2 ACTA2
33 11.86 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
34
Show member pathways
11.85 TGFBR2 TGFBR1 SMAD4 SMAD3 LOX
35 11.83 TGFBR1 TGFB3 TGFB2
36 11.81 TGFBR2 TGFBR1 SMAD4 SMAD3
37
Show member pathways
11.81 TGFB3 TGFB2 LOX FBN1 ELN
38 11.8 TGFBR2 TGFBR1 SMAD4 SMAD3
39
Show member pathways
11.8 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
40
Show member pathways
11.79 TGFBR2 TGFBR1 SMAD4 SMAD3
41 11.7 TGFBR2 TGFBR1 SMAD4 SMAD3
42 11.7 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
43
Show member pathways
11.6 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
44 11.6 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
45 11.58 TGFBR1 SMAD4 SMAD3
46 11.56 TGFBR2 TGFBR1 TGFB2
47 11.56 TGFBR2 TGFBR1 TGFB3 SMAD4 SMAD3
48 11.47 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
49
Show member pathways
11.32 TGFBR2 TGFBR1 TGFB3 SMAD4
50 11.27 TGFBR2 TGFBR1 TGFB3

GO Terms for Aortic Dissection

Cellular components related to Aortic Dissection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.95 TGFB3 TGFB2 LOX FBN1 COL5A2 COL3A1
2 cell GO:0005623 9.85 TGFBR1 SMAD4 SMAD3 NDE1 LOX LDLR
3 collagen trimer GO:0005581 9.5 LOX COL5A2 COL3A1
4 receptor complex GO:0043235 9.46 TGFBR2 TGFBR1 SMAD3 LDLR
5 extracellular matrix GO:0031012 9.35 LOX FBN1 ELN COL5A2 COL3A1
6 SMAD protein complex GO:0071141 9.26 SMAD4 SMAD3
7 collagen-containing extracellular matrix GO:0062023 9.1 TGFB3 TGFB2 FBN1 ELN COL5A2 COL3A1

Biological processes related to Aortic Dissection according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 10.1 TGFBR1 TGFB3 SMAD4 SMAD3 ACTA2
2 negative regulation of cell proliferation GO:0008285 10.06 TGFBR2 TGFB3 TGFB2 SMAD4 SMAD3
3 extracellular matrix organization GO:0030198 9.98 LOX FBN1 ELN COL5A2 COL3A1
4 regulation of cell proliferation GO:0042127 9.97 TGFBR2 TGFB3 TGFB2 SMAD4
5 in utero embryonic development GO:0001701 9.97 TGFBR2 TGFBR1 TGFB3 SMAD4 SMAD3
6 heart development GO:0007507 9.93 TGFBR2 TGFBR1 TGFB2 LOX FBN1 COL3A1
7 kidney development GO:0001822 9.92 TGFBR1 TGFB2 SMAD4 FBN1
8 response to hypoxia GO:0001666 9.91 TGFBR2 TGFB3 TGFB2 SMAD4 SMAD3
9 cell cycle arrest GO:0007050 9.89 TGFBR1 TGFB2 SMAD3
10 negative regulation of cell growth GO:0030308 9.89 TGFB2 SMAD4 SMAD3
11 male gonad development GO:0008584 9.88 TGFBR1 TGFB2 SMAD4
12 BMP signaling pathway GO:0030509 9.87 TGFB3 TGFB2 SMAD4
13 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.86 TGFBR2 TGFBR1 TGFB3 SMAD3
14 skeletal system development GO:0001501 9.85 TGFBR1 TGFB2 SMAD3 FBN1 COL5A2 COL3A1
15 blood vessel development GO:0001568 9.84 TGFBR2 LOX COL3A1
16 cellular response to transforming growth factor beta stimulus GO:0071560 9.84 TGFBR1 SMAD3 FBN1
17 positive regulation of stress fiber assembly GO:0051496 9.83 TGFBR1 TGFB3 SMAD3
18 SMAD protein signal transduction GO:0060395 9.83 TGFB3 TGFB2 SMAD4 SMAD3
19 gastrulation GO:0007369 9.81 TGFBR2 SMAD4 SMAD3
20 embryonic cranial skeleton morphogenesis GO:0048701 9.8 TGFBR2 TGFBR1 SMAD3
21 digestive tract development GO:0048565 9.8 TGFBR2 TGFB3 COL3A1
22 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.8 TGFBR1 TGFB3 TGFB2 SMAD4
23 outflow tract septum morphogenesis GO:0003148 9.78 TGFBR2 TGFB2 SMAD4
24 ventricular septum morphogenesis GO:0060412 9.78 TGFBR2 TGFBR1 TGFB2 SMAD4
25 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 9.77 SMAD4 SMAD3 LOX
26 cell-cell junction organization GO:0045216 9.77 TGFB3 TGFB2 SMAD3
27 activin receptor signaling pathway GO:0032924 9.74 TGFBR2 TGFBR1 SMAD3
28 positive regulation of SMAD protein signal transduction GO:0060391 9.72 TGFBR1 TGFB3 SMAD4
29 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.71 TGFBR2 TGFBR1
30 uterus development GO:0060065 9.71 TGFB2 SMAD4
31 ventricular trabecula myocardium morphogenesis GO:0003222 9.71 TGFBR1 TGFB2
32 pathway-restricted SMAD protein phosphorylation GO:0060389 9.71 TGFBR2 TGFBR1 TGFB2
33 cardiac epithelial to mesenchymal transition GO:0060317 9.7 TGFBR1 TGFB2
34 atrioventricular valve morphogenesis GO:0003181 9.7 TGFBR2 TGFB2
35 response to cholesterol GO:0070723 9.69 TGFBR2 TGFBR1
36 elastic fiber assembly GO:0048251 9.69 MYH11 LOX
37 endothelial cell activation GO:0042118 9.68 TGFBR1 SMAD4
38 salivary gland morphogenesis GO:0007435 9.68 TGFB3 TGFB2
39 membranous septum morphogenesis GO:0003149 9.68 TGFBR2 TGFB2
40 regulation of striated muscle tissue development GO:0016202 9.68 SMAD3 LOX
41 SMAD protein complex assembly GO:0007183 9.67 SMAD4 SMAD3
42 negative regulation of macrophage cytokine production GO:0010936 9.65 TGFB3 TGFB2
43 regulation of binding GO:0051098 9.65 SMAD4 SMAD3
44 collagen fibril organization GO:0030199 9.65 TGFBR1 TGFB2 LOX COL5A2 COL3A1
45 endocardial cushion fusion GO:0003274 9.64 TGFBR2 TGFB2
46 positive regulation of tight junction disassembly GO:1905075 9.64 TGFBR1 TGFB3
47 positive regulation of epithelial to mesenchymal transition GO:0010718 9.63 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
48 secondary palate development GO:0062009 9.62 TGFBR2 TGFB3 TGFB2 SMAD4
49 uterine wall breakdown GO:0042704 9.61 TGFB3 TGFB2
50 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.61 TGFBR2 TGFBR1 TGFB2

Molecular functions related to Aortic Dissection according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.39 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD4 SMAD3
2 extracellular matrix structural constituent GO:0005201 9.62 FBN1 ELN COL5A2 COL3A1
3 collagen binding GO:0005518 9.58 SMAD4 SMAD3 LOX
4 activin binding GO:0048185 9.54 TGFBR2 TGFBR1
5 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.52 TGFBR2 TGFBR1
6 I-SMAD binding GO:0070411 9.49 TGFBR1 SMAD4
7 type I transforming growth factor beta receptor binding GO:0034713 9.48 TGFBR2 TGFB3
8 extracellular matrix constituent conferring elasticity GO:0030023 9.46 FBN1 ELN
9 transforming growth factor beta-activated receptor activity GO:0005024 9.43 TGFBR2 TGFBR1
10 transforming growth factor beta binding GO:0050431 9.43 TGFBR2 TGFBR1 TGFB3
11 type III transforming growth factor beta receptor binding GO:0034714 9.37 TGFB3 TGFB2
12 transforming growth factor beta receptor binding GO:0005160 9.33 TGFB3 TGFB2 SMAD3
13 type II transforming growth factor beta receptor binding GO:0005114 9.13 TGFBR1 TGFB3 TGFB2
14 SMAD binding GO:0046332 9.02 TGFBR2 TGFBR1 SMAD3 COL5A2 COL3A1

Sources for Aortic Dissection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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