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MCID: ART012
MIFTS: 44

Aortitis

Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Aortitis

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MalaCards integrated aliases for Aortitis:

Name: Aortitis 12 43 15 17 71

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:519
MeSH 43 D001025
NCIt 49 C97085
SNOMED-CT 67 70933002
ICD10 32 I77.6 I79.1
UMLS 71 C0003509
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Summaries for Aortitis

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MalaCards based summary : Aortitis is related to takayasu arteritis and aortic valve insufficiency. An important gene associated with Aortitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs rituximab and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include heart, colon and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Aortitis is the inflammation of the aortic wall. The disorder is potentially life-threatening and rare.... more...

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Related Diseases for Aortitis

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Diseases related to Aortitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 920)
# Related Disease Score Top Affiliating Genes
1 takayasu arteritis 31.5 TNF IL6 IL1RN IL1B CRP CD40LG
2 aortic valve insufficiency 31.3 SRSF6 MRAP ELN CRP
3 aortic aneurysm, familial abdominal, 1 30.9 IL6 ELN CRP
4 anca-associated vasculitis 30.6 PRTN3 MPO
5 igg4-related disease 30.5 PRTN3 CRP CD4
6 relapsing polychondritis 30.5 IL6 IL17A CRP
7 interstitial keratitis 30.4 MRAP CD40LG
8 infective endocarditis 30.3 TNF IL6 IL17A CRP
9 tolosa-hunt syndrome 30.3 PRTN3 CRP
10 crescentic glomerulonephritis 30.2 PRTN3 MPO IL1RN
11 carotid stenosis 30.1 TNF MPO CRP
12 pulmonary embolism 30.1 MPO CRP CD40LG
13 rheumatic fever 30.0 TNF IL6 CD40LG
14 endocarditis 30.0 TNFRSF1B TNF IL6 IL17A CRP
15 antiphospholipid syndrome 30.0 TNF CRP CD40LG
16 intermittent claudication 30.0 IL6 CRP CD40LG
17 pyoderma gangrenosum 30.0 TNFRSF1B TNF IL1RN
18 congestive heart failure 30.0 TNF IL6 IL1B CRP
19 pulmonary tuberculosis 29.9 TNF IL6 IL1B CRP
20 splenic infarction 29.9 PRTN3 CRP CD40LG
21 acalculous cholecystitis 29.9 CRP CD40LG
22 tertiary syphilis 29.9 CRP CD40LG CD4
23 diverticulitis 29.9 TNF IL6 CRP
24 glomerulonephritis 29.9 PRTN3 MPO IL1B CD40LG
25 obstructive jaundice 29.8 TNF IL6 CRP
26 pulmonary edema 29.8 TNF IL1B CRP
27 pulmonary artery disease 29.8 IL6 CRP CD40LG
28 systemic autoimmune disease 29.8 IL6 IL17A CRP
29 thrombophlebitis 29.8 TNF CRP CD40LG
30 collagen disease 29.7 ELN CRP CD40LG
31 subacute bacterial endocarditis 29.7 PRTN3 MPO CRP CD40LG
32 coronary aneurysm 29.7 TNF IL6 IL1RN CRP
33 rapidly progressive glomerulonephritis 29.6 PRTN3 MPO CRP CD40LG
34 pericardial tuberculosis 29.6 CRP CD4
35 hyperthyroidism 29.6 TNF PRTN3 IL6 CRP
36 asymptomatic neurosyphilis 29.6 CD40LG CD4
37 pyuria 29.6 PRTN3 IL6 CRP CD40LG
38 end stage renal disease 29.6 TNF IL6 IL1RN CRP
39 familial hypercholesterolemia 29.5 TNF MPO IL6 CRP
40 spondyloarthropathy 29.5 TNF IL6 IL1B IL17A
41 spondylitis 29.5 TNFRSF1B TNF IL6 IL1RN IL17A CRP
42 pancreatitis 29.5 TNF IL6 IL1B CRP
43 osteomyelitis 29.4 TNF IL6 IL1RN IL1B
44 poems syndrome 29.4 TNF IL6 IL1B
45 aphthous stomatitis 29.4 TNF IL6 IL1RN IL1B
46 gastroenteritis 29.4 TNF IL6 IL1RN IL1B CRP
47 arteries, anomalies of 29.4 TNF IL6 IL1B CRP
48 latent syphilis 29.4 CD40LG CD4
49 alcoholic liver cirrhosis 29.3 TNF IL6 IL1B
50 autoimmune hepatitis 29.3 TNF IL6 CD40LG

Graphical network of the top 20 diseases related to Aortitis:



Diseases related to Aortitis
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Symptoms & Phenotypes for Aortitis

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GenomeRNAi Phenotypes related to Aortitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.32 CD40LG IL17A IL1B MPO TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.32 IL17A IL1B MPO TNF TNFRSF1B

MGI Mouse Phenotypes related to Aortitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.85 CD4 CD40LG IL17A IL1B IL1RN IL6
2 immune system MP:0005387 9.7 CD4 CD40LG CRP IL17A IL1B IL1RN
3 integument MP:0010771 9.23 CD4 CD40LG IL17A IL1B IL1RN IL6
Sources

Drugs & Therapeutics for Aortitis

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Drugs for Aortitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
2 Immunologic Factors Phase 1, Phase 2
3 Antirheumatic Agents Phase 1, Phase 2
4 Antineoplastic Agents, Immunological Phase 1, Phase 2
5 Immunoglobulins
6 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Tocilizumab Dose-tapering and Interruption in Patients With Giant Cell Arteritis Achieving the Clinical Remission: a Prospective, Pilot Study. Unknown status NCT03244709 Phase 4 Tocilizumab
2 Rituximab (RTX) for IgG4-related Disease (IgG4-RD): a Prospective,Open-label Trial Completed NCT01584388 Phase 1, Phase 2 Rituximab
3 VCRC Longitudinal Protocol for Aortitis Completed NCT03022331
4 Contrast Enhanced Ultrasound for Assessment of Carotid Artery Neovascularization as a Marker of Disease Activity in Takayasu's Arteritis and Giant Cell Arteritis Completed NCT01795456
5 Aortitis and Retroperitoneal Fibrosis: Evaluation of Diagnostic Criteria Recruiting NCT03133949
6 Study of Thrombotic Complications After Abdominal Aortic Aneurysm Surgery With or Without Infection: AAA-IT Recruiting NCT04325373
7 VCRC Tissue Biorepository Collection Protocol Recruiting NCT02967068
8 Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis Recruiting NCT02257866

Search NIH Clinical Center for Aortitis

Cochrane evidence based reviews: aortitis

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Genetic Tests for Aortitis

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Anatomical Context for Aortitis

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MalaCards organs/tissues related to Aortitis:

40
Heart, Colon, Testes, Lung, Liver, Thyroid, Neutrophil
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Publications for Aortitis

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Articles related to Aortitis:

(show top 50) (show all 2131)
# Title Authors PMID Year
1
HIV-Associated Aortitis Causing Rapid Development of an Abdominal Aortic Aneurysm. 61
32018021 2020
2
18F-FDG PET/CT Imaging of Vasculitis Complicated With Relapsing Polychondritis. 61
32433175 2020
3
Complete aortic replacement in aortitis due to aseptic abscess syndrome. 61
32368703 2020
4
Is There a Brain/Heart Interaction in Rheumatoid Arthritis and Seronegative Spondyloartropathies? A Combined Brain/Heart Magnetic Resonance Imaging Reveals the Answer. 61
32562092 2020
5
Aortitis in the setting of catastrophic antiphospholipid syndrome in a patient with systemic lupus erythematosus. 61
32517572 2020
6
Antineoplastic Drug-induced Aortitis: An Unraveled Adverse Effect Using the World Health Organization Pharmacovigilance Database. 61
32482651 2020
7
Migratory Aortitis Associated with Granulocyte-colony-stimulating Factor. 61
32188815 2020
8
Immunoglobulin G4-related thoracic aortitis. 61
31858218 2020
9
Correction to: Etiology, Diagnosis and Management of Aortitis. 61
32494831 2020
10
Active Aortitis and Dissection in Giant Cell Arteritis While on Tocilizumab Monotherapy. 61
32496362 2020
11
[A Case of Aortitis Caused by a Granulocyte-Colony-Stimulating Factor during Chemotherapy for Pancreatic Cancer]. 61
32408335 2020
12
State of the Art Management of Aortic Valve Disease in Ankylosing Spondylitis. 61
32410005 2020
13
Clostridium septicum-infected aortic aneurysm or graft is a deadly diagnosis. 61
31843297 2020
14
Vascular findings on FDG PET/CT. 61
32356457 2020
15
IgG4-related aortitis/periaortitis and periarteritis: a distinct spectrum of IgG4-related disease. 61
32366271 2020
16
Syphilitic aortitis: still a current common cause of aneurysm of the tubular portion of ascending aorta. 61
31951962 2020
17
Etiology, Diagnosis and Management of Aortitis. 61
32390100 2020
18
Large vessel vasculitis secondary to granulocyte-colony stimulating factor. 61
32452726 2020
19
Noninfectious aortitis: A case report. 61
32356683 2020
20
Giant cell aortitis. 61
32472314 2020
21
Lymphadenitis and aortitis due to Brucella melitensis infection. 61
31950431 2020
22
Saprochaete capitata aortitis in an immunocomopetent patient after myocardial revascularization. 61
32470823 2020
23
Endovascular aortic aneurysm repair to facilitate computed tomography-guided biopsy and aid diagnosis in a case of presumed immunoglobulin G4 aortitis. 61
32267992 2020
24
Familial HLA-B*52 Vasculitis: Maternal, Atypical Cogan's Syndrome with Takayasu Arteritis-mimicking Aortitis and Filial Takayasu Arteritis. 61
32321889 2020
25
Infectious aortitis mimicking Takayasu disease. 61
32265023 2020
26
FDG-PET/CT diagnosis of aortitis and pseudoaneurysms. 61
32180135 2020
27
The Fugitive Finding: Acute Infectious Aortitis in a Patient with Persistent MRSA Bacteremia. 61
31476290 2020
28
Aortitis-related isolated coronary artery ostial stenosis treated by retrograde-wire technique and intravascular ultrasound for primary percutaneous coronary intervention. 61
32271236 2020
29
Role of positron emission tomography in the assessment of disease burden and risk of relapse in patients affected by giant cell arteritis. 61
31713732 2020
30
Cranial and large vessel activity on positron emission tomography scan at diagnosis and 6 months in giant cell arteritis. 61
32100451 2020
31
Interleukin-1 Beta-Mediated Sex Differences in Kawasaki Disease Vasculitis Development and Response to Treatment. 61
31996019 2020
32
Mucormycosis with peculiar aortic involvement in a child with acute lymphoblastic leukemia. 61
31847684 2020
33
Hybrid Repair for Mega-Aortic Syndrome due to Giant Cell Aortitis in a Heart Failure Patient. 61
32273927 2020
34
Bilateral End-Organ Endophthalmitis in Setting of Serratia marcescens Urosepsis on 18F-FDG PET/CT. 61
31876818 2020
35
Aortitis and periaortitis: The puzzling spectrum of inflammatory aortic diseases. 61
32234379 2020
36
IgG4-related pleural disease with aortitis and submandibular glands involvement successfully treated with corticosteroid: case-based review. 61
32206878 2020
37
18F-FDG PET/MRI compared with clinical and serological markers for monitoring disease activity in patients with aortitis and chronic periaortitis. 61
32242814 2020
38
IgG4-related dacryocystitis and aortitis: A new association. 61
30642193 2020
39
Value of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Diagnosis of Spondyloarthropathy-Related Aortitis. 61
32028301 2020
40
Association of IgG4-Related Arteritis With Recurrent Stroke. 61
31796239 2020
41
Comparison of Aortitis Versus Noninflammatory Aortic Aneurysms Among Patients Who Undergo Open Aortic Aneurysm Repair. 61
32067388 2020
42
Multimodal Imaging of Granulomatosis With Polyangiitis Aortitis Complicated by Severe Aortic Regurgitation and Complete Heart Block. 61
32069115 2020
43
Clinically isolated aortitis successfully treated with methotrexate monotherapy. 61
32031659 2020
44
Clostridium septicum aortitis: A kiss of the devil. 61
31872897 2020
45
Lyme aortitis. 61
31941668 2020
46
Mechanism and biomarkers in aortitis--a review. 61
31664480 2020
47
Ankylosing Spondyloarthritis Resulting Severe Aortic Insufficiency and Aortitis: Exacerbation of Ankylosing Spondyloarthritis and Stenosis of the Main Left Coronary Artery after Mechanical Aortic Valve Implantation with Cardiopulmonary Bypass. 61
31984147 2020
48
Clostridium septicum-infected Stanford type A acute aortic dissection: a case report. 61
31950362 2020
49
Phenotyping of IgG4-related diseases based on affected organ pattern: A multicenter cohort study using cluster analysis. 61
31902317 2020
50
High index of suspicion for brucellosis in a highly cosmopolitan city in southern China. 61
31914937 2020
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Variations for Aortitis

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Expression for Aortitis

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Search GEO for disease gene expression data for Aortitis.
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Pathways for Aortitis

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Pathways related to Aortitis according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.98 TNFRSF1B TNF PRTN3 MPO IL6 IL1RN
2
ERK Signaling 63
Show member pathways
 13.78 TNFRSF1B TNF IL6 IL1B IL17A ELN
3
PEDF Induced Signaling 63
Show member pathways
 13.63 TNFRSF1B TNF IL6 IL1RN IL1B IL17A
4
Akt Signaling 63
Show member pathways
 13.37 TNFRSF1B TNF IL6 IL1B IL17A CD40LG
5
PAK Pathway 63
Show member pathways
 13.27 TNFRSF1B TNF IL6 IL1B IL17A CD40LG
6
Cytokine Signaling in Immune system 65
Show member pathways
 13.17 TNFRSF1B TNF PRTN3 IL6 IL1RN IL1B
7
Human cytomegalovirus infection 36
Show member pathways
 12.89 TNFRSF1B TNF IL6 IL1B CD4
8
Allograft rejection 1 36
Show member pathways
 12.82 TNF IL6 IL1B IL17A CD40LG CD4
9
NF-KappaB Family Pathway 63
Show member pathways
 12.68 TNFRSF1B TNF IL6 IL1B CD40LG
10
4-1BB Pathway 63
Show member pathways
 12.64 TNFRSF1B TNF IL1B CD40LG CD4
11
Th17 cell differentiation 36
Show member pathways
 12.57 TNF IL6 IL1B IL17A CD4
12
T cell receptor signaling pathway 36
Show member pathways
 12.5 TNF IL6 IL1B IL17A CD40LG CD4
13
Immune response IL-23 signaling pathway 22
Show member pathways
 12.47 TNF MPO IL6 IL1B IL17A CD4
14
IL-17 Family Signaling Pathways 64
Show member pathways
 12.31 TNF IL6 IL1B IL17A
15
Folate Metabolism 1
Show member pathways
 12.28 TNF MPO IL6 IL1B CRP
16
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.16 TNF IL6 IL1RN IL1B
17
NF-kappaB Signaling 4
12.01 TNFRSF1B TNF MPO IL1RN IL1B IL17A
18
Hematopoietic Stem Cells and Lineage-specific Markers 64
11.98 TNF MPO IL6 CD4
19
TNF signaling pathway 36
11.96 TNFRSF1B TNF IL6 IL1B
20
NF-kappa B signaling pathway 36
11.9 TNF IL1B CD40LG
21
Amoebiasis 36
11.89 TNF IL6 IL1B
22
Hematopoietic cell lineage 36
11.89 TNF IL6 IL1B CD4
23
AGE-RAGE signaling pathway in diabetic complications 36
11.87 TNF IL6 IL1B
24
Rheumatoid arthritis 36
11.85 TNF IL6 IL1B IL17A
25
Th17 Differentiation 64
Show member pathways
 11.84 IL6 IL1B IL17A CD4
26
Interleukin-4 and 13 signaling 65
11.82 TNFRSF1B TNF IL6 IL1B IL17A
27
TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions 64
Show member pathways
 11.78 TNFRSF1B TNF CD40LG
28
Innate Lymphoid Cells Differentiation 64
11.76 TNF IL1B IL17A CD4
29
C-MYB transcription factor network 1
11.75 PRTN3 MPO CD4
30
Pertussis 36
11.74 TNF IL6 IL1B
31
IL27-mediated signaling events 1
Show member pathways
 11.74 TNF IL6 IL1B IL17A CD4
32
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 22
Show member pathways
 11.72 TNFRSF1B TNF CD40LG
33
Dendritic Cells Developmental Lineage Pathway 64
11.69 TNF IL6 IL1B CD4
34
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.61 TNF IL6 IL1B CD40LG
35
Legionellosis 36
11.6 TNF IL6 IL1B
36
Lung fibrosis 1
11.6 TNF IL6 IL1B ELN
37
amb2 Integrin signaling 1
11.52 TNF MPO IL6
38
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.49 TNF IL6 IL1B
39
Malaria 36
11.43 TNF IL6 IL1B CD40LG
40
African trypanosomiasis 36
11.38 TNF IL6 IL1B
41
IL-10 Pathway 63
11.35 TNF IL6 IL1B
42
Antifolate resistance 36
11.29 TNF IL6 IL1B
43
Development and heterogeneity of the ILC family 1
11.06 TNF IL6 IL1B IL17A
44
Overview of nanoparticle effects 1
11.02 TNF IL6 CRP
45
G-protein signaling_Rap2B regulation pathway 22
10.99 TNF IL6 IL1B IL17A ELN CD40LG
46
LDL Oxidation in Atherogenesis 63
10.92 TNF MPO IL1B
47
Cytokines and Inflammatory Response 1
10.92 TNF IL6 IL1B CD4
48
IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types 64
10.77 IL6 IL1B
49
Interleukin-10 signaling 65
10.71 TNFRSF1B TNF IL6 IL1RN IL1B
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GO Terms for Aortitis

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Cellular components related to Aortitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 TNF PRTN3 MPO IL6 IL1RN IL1B
2 membrane raft GO:0045121 9.46 TNFRSF1B TNF PRTN3 CD4
3 extracellular region GO:0005576 9.36 TNFRSF1B TNF PRTN3 MPO IL6 IL1RN

Biological processes related to Aortitis according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.85 TNFRSF1B TNF IL6 IL1B
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 TNF IL6 IL1B CD40LG
3 response to glucocorticoid GO:0051384 9.77 TNF IL6 IL1RN
4 immune response GO:0006955 9.76 TNFRSF1B TNF IL6 IL1RN IL1B IL17A
5 positive regulation of interleukin-6 production GO:0032755 9.75 TNF IL6 IL1B
6 positive regulation of interleukin-6 secretion GO:2000778 9.69 TNF IL1B IL17A
7 positive regulation of T cell proliferation GO:0042102 9.67 IL6 IL1B CD40LG CD4
8 negative regulation of neurogenesis GO:0050768 9.65 TNF IL6 IL1B
9 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.63 TNF IL6 IL17A
10 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.62 IL1B CD4
11 positive regulation of chemokine biosynthetic process GO:0045080 9.62 TNF IL1B
12 regulation of neuroinflammatory response GO:0150077 9.61 TNFRSF1B IL6
13 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.61 TNF IL17A
14 positive regulation of glial cell proliferation GO:0060252 9.61 TNF IL6 IL1B
15 regulation of establishment of endothelial barrier GO:1903140 9.6 TNF IL1B
16 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.58 IL6 IL1RN
17 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 TNFRSF1B TNF IL1B
18 regulation of immunoglobulin secretion GO:0051023 9.57 TNF CD40LG
19 positive regulation of fever generation GO:0031622 9.56 TNF IL1B
20 inflammatory response GO:0006954 9.56 TNFRSF1B TNF IL6 IL1RN IL1B IL17A
21 sequestering of triglyceride GO:0030730 9.54 TNF IL1B
22 positive regulation of neuroinflammatory response GO:0150078 9.5 TNF IL6 IL1B
23 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 TNF IL1B
24 negative regulation of lipid storage GO:0010888 9.43 TNF IL6 CRP
25 cytokine-mediated signaling pathway GO:0019221 9.23 TNFRSF1B TNF PRTN3 IL6 IL1RN IL1B

Molecular functions related to Aortitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 TNF IL6 IL1RN IL1B IL17A CD40LG
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Sources for Aortitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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