Aortitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Aortitis is related to takayasu arteritis and aortic atherosclerosis. An important gene associated with Aortitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include heart, colon and bone marrow, and related phenotypes are immune system and cardiovascular system

Wikipedia: ⁷⁵ Aortitis is the inflammation of the aortic wall. The disorder is potentially life-threatening and rare.... more...

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Related Diseases for Aortitis

Diseases related to Aortitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1144)

#	Related Disease	Score	Top Affiliating Genes
1	takayasu arteritis	32.2	TNF IL6 HLA-DRB1 CRP
2	aortic atherosclerosis	31.3	TNF IL6 IL1B CRP
3	aortic valve insufficiency	31.1	SRSF6 FBN1 ELN CRP
4	igg4-related disease	30.8	PRTN3 MPO CRP CD4 CCR6
5	aortic dissection	30.7	IL6 FBN1 ELN CRP
6	angina pectoris	30.7	TNF IL6 CRP
7	cogan syndrome	30.7	TNF PRTN3 CRP
8	infective endocarditis	30.7	PRTN3 MPO IL6 CRP CCR6
9	aortic valve disease 2	30.6	FBN1 ELN CRP
10	interstitial keratitis	30.5	TNF PRTN3 CRP
11	tertiary syphilis	30.5	TNF PRTN3 CRP CD4
12	aortic aneurysm	30.4	TNF IL6 IL1B FBN1 ELN CRP
13	vascular disease	30.3	TNF MPO IL6 FBN1 ELN CRP
14	neutrophilia, hereditary	30.3	MPO IL6 CSF3 CRP
15	endocarditis	30.3	TNF IL6 IL17A IFNG CRP
16	mitral valve insufficiency	30.2	FBN1 ELN CRP
17	secondary syphilis	30.2	TNF CRP CD4
18	hemopericardium	30.2	FBN1 CRP
19	pericardial effusion	30.2	TNF IL6 CRP CD4
20	reactive arthritis	30.1	TNF PRTN3 IL17A CRP CCR6
21	iga glomerulonephritis	30.1	PRTN3 IL6 CCR6
22	syphilis	30.1	TNF PRTN3 IL17A HLA-DRB1 CRP CD4
23	gas gangrene	30.1	TNF IL6 CRP
24	serum amyloid a amyloidosis	30.1	TNF IL6 CRP
25	limb ischemia	30.0	IL6 CSF3 CRP
26	purulent endophthalmitis	30.0	CRP CD4
27	mediastinitis	29.9	MPO IL6 CRP CD4
28	subacute bacterial endocarditis	29.9	PRTN3 MPO CRP
29	splenic infarction	29.9	PRTN3 MPO CRP
30	polyarteritis nodosa	29.9	TNF PRTN3 MPO IL6 HLA-DRB1 CRP
31	acalculous cholecystitis	29.9	CRP CD4
32	pyuria	29.9	PRTN3 IL6 CRP
33	tolosa-hunt syndrome	29.9	PRTN3 CRP
34	pleural empyema	29.9	IL6 CRP CD4
35	autoimmune pancreatitis	29.9	CRP CD4 CCR6
36	inflammatory bowel disease 1	29.9	TNF IL6 IL1B IL17A CCR6
37	aortic aneurysm, familial thoracic 1	29.8	TNF IL6 IL1B FBN1 ELN CRP
38	haemophilus influenzae	29.8	TNF IL1B
39	nocardiosis	29.8	TNF CRP CD4
40	granulocytopenia	29.8	MPO CSF3
41	peripheral vascular disease	29.8	TNF IL6 IL1B CRP
42	aortic disease	29.8	TNF IL6 IL1B FBN1 ELN CRP
43	subclavian artery aneurysm	29.8	FBN1 ELN
44	vasculitis	29.7	TNF PRTN3 MPO IL6 IL1B IL17A
45	aortic aneurysm, familial abdominal, 1	29.7	TNF IL6 IL1B FBN1 ELN CRP
46	kawasaki disease	29.7	TNF ELN CRP
47	diverticulitis	29.7	TNF IL6 CRP CCR6
48	pulmonary artery disease	29.7	TNF IL6 CRP CCR6
49	back pain	29.7	IL6 IL1RN IL1B CRP
50	hyperthyroidism	29.7	TNF PRTN3 IL6 CRP

Graphical network of the top 20 diseases related to Aortitis:

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Symptoms & Phenotypes for Aortitis

MGI Mouse Phenotypes related to Aortitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	10.07	CCR6 CD4 CRP CSF3 FBN1 IFNG
2	cardiovascular system	MP:0005385	10.02	CCR6 CRP ELN FBN1 IFNG IL1B
3	skeleton	MP:0005390	9.81	ELN FBN1 HLA-DRB1 IFNG IL17A IL1B
4	hematopoietic system	MP:0005397	9.73	CCR6 CD4 CSF3 FBN1 IFNG IL17A
5	integument	MP:0010771	9.28	CD4 CSF3 FBN1 IFNG IL17A IL1B

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Drugs & Therapeutics for Aortitis

Interventional clinical trials:

#	Name	Status	NCT ID
1	Aortitis and Retroperitoneal Fibrosis: Evaluation of Diagnostic Criteria	Unknown status	NCT03133949
2	VCRC Longitudinal Protocol for Aortitis	Completed	NCT03022331
3	Contrast Enhanced Ultrasound for Assessment of Carotid Artery Neovascularization as a Marker of Disease Activity in Takayasu's Arteritis and Giant Cell Arteritis	Completed	NCT01795456
4	VCRC Tissue Biorepository Collection Protocol	Recruiting	NCT02967068

Search NIH Clinical Center for Aortitis

Cochrane evidence based reviews: aortitis

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Genetic Tests for Aortitis

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Anatomical Context for Aortitis

Organs/tissues related to Aortitis:

MalaCards : Heart, Colon, Bone Marrow, Spinal Cord, Breast, Lung, Liver

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Publications for Aortitis

Articles related to Aortitis:

(show top 50) (show all 2385)

#	Title	Authors	PMID	Year
1	The Great Masquerader: Coronary Occlusion From Thrombus in Ascending Aortic Aneurysm Causing Anterior-Wall STEMI With Cardiogenic Shock. ⁶²	Kanjanarutjawiwat W...Makarasen P	36200998	2022
2	Long-Term Clinical and Radiographic Outcomes in Patients With Clinically Isolated Aortitis. ⁶²	Mayer A...Rhee RL	36250477	2022
3	Cardiac arrest caused by ruptured nonaneurysmal infectious aortitis. ⁶²	Huang CH...Lien WC	36260217	2022
4	Infectious aortitis complicating ruptured mycotic aneurysm due to Aeromonas sobria bacteremia. ⁶²	Ju KS...Lee WS	36037846	2022
5	Reversal of IgG4-related aortitis after treatment evidenced by [18F]FDG PET/CT. ⁶²	Piva TM...Wichert-Ana L	36129564	2022
6	[Aortic Root Pseudoaneurysm]. ⁶²	Yamauchi H	36155567	2022
7	[Emergency Operation for Impending Rupture of Syphilitic Aortic Aneurysm with Left Coronary Ostial Stenosis:Report of a Case]. ⁶²	Kasuga K...Kojima S	36156517	2022
8	Varicella zoster virus and cardiovascular diseases. ⁶²	Cersosimo A...Vizzardi E	36128930	2022
9	The role of PET/CT in large vessel vasculitis and related disorders: diagnosis, extent evaluation and assessment of therapy response. ⁶²	Jamar F...Gheysens O	36066110	2022
10	Fully integrated [18F]FDG PET/MR in large vessel vasculitis. ⁶²	Padoan R...Schiavon F	31602964	2022
11	Granulocyte colony-stimulating factor-associated aortitis in a woman with breast cancer: a case report. ⁶²	Matsumoto N...Toyama T	35980544	2022
12	Inflammatory Diseases of the Aorta: JACC Focus Seminar, Part 2. ⁶²	Kadian-Dodov D...Olin JW	35981827	2022
13	A Case of Seronegative Primary Sjögren's Syndrome Complicated by Takayasu Arteritis in a Japanese Girl. ⁶²	Yamanishi S...Itoh Y	35953299	2022
14	Giant cell arteritis-related stroke in a large inception cohort: A comparative study. ⁶²	Parreau S...Liozon E	35512621	2022
15	Emergent Magnetic Resonance Angiography for Evaluation of the Thoracoabdominal and Peripheral Vasculature. ⁶²	Ludwig DR...Bhalla S	35995474	2022
16	Inflammatory Thoracic Aortic Aneurysm in a Patient with Advanced Lung Adenocarcinoma Treated with Pembrolizumab. ⁶²	Ninomiya R...Tachibana I	35022350	2022
17	Aortitis presenting as acute myeloid leukemia - A case report. ⁶²	Ireifej B...Jaiswal V	36045831	2022
18	ANCA-associated vasculitis and IgG4-related disease overlap syndrome: a case report and literature review. ⁶²	Faz-Munoz D...Martin-Nares E	35449491	2022
19	Single-Center Analysis of Pegfilgrastim-induced Aortitis Using a Drug Prescription Database and CT Findings. ⁶²	Takamatsu A...Gabata T	35943335	2022
20	Global Transcriptomic Profiling Identifies Differential Gene Expression Signatures Between Inflammatory and Noninflammatory Aortic Aneurysms. ⁶²	Hur B...Sung J	35403833	2022
21	High risk and low prevalence diseases: Giant cell arteritis. ⁶²	Lacy A...Long B	35688119	2022
22	Whipple's aortitis. ⁶²	Depascale R...Padoan R	35078215	2022
23	Multiple Anastomotic Dehiscences After the Bentall Procedure for Aortitis Syndrome. ⁶²	Kobayashi K...Uchida T	36038468	2022
24	Pegfilgrastim-induced Aortitis: Cardiovascular Diagnosis in the Oncologic Setting. ⁶²	Krinsky G	35943341	2022
25	Systematic literature review and meta-analysis of Clostridium septicum aortitis. ⁶²	Kirchweger P...Fugger R	35358668	2022
26	Tuberculosis and Cardiovascular Complications: An Overview. ⁶²	Adefuye MA...Adefuye BO	36158349	2022
27	Immunoglobulin G4-related coronary periarteritis: a systematic literature review with a case series. ⁶²	Ito T...Okada M	35445950	2022
28	A case report of recurrent acute myocardial infarction and cardiac arrest due to aortic dissection secondary to IgG4-related aortitis. ⁶²	Achim A...Toth GG	35143994	2022
29	Porto-Sinusoidal Vascular Disease in a Patient With Diffuse Aortitis and Massive Ascites. ⁶²	Lin E...Lee BT	35811580	2022
30	Infectious aortitis from pyogenic spondylitis and psoas abscess: Case report. ⁶²	Jung KY...Chung H	35775686	2022
31	[Sweet syndrome of childhood with acquired cutis laxa (Marshall syndrome) as primary manifestation of Takayasu arteritis]. ⁶²	Michl C...Sunderkotter C	35925217	2022
32	Takayasu's Arteritis With Acute Severe Aortic Regurgitation Requiring a Bio-Bentall Procedure. ⁶²	Jules P...Ahmed R	35989796	2022
33	Retrospective multicentric study comparing infectious and non-infectious aortitis. ⁶²	Carrer M...Puges M	35792621	2022
34	Recent advances in the diagnosis and therapy of large vessel vasculitis. ⁶²	Keser G...Soy M	35699647	2022
35	Unexplained chest pain in a patient with giant cell arteritis? Think aortic dissection. ⁶²	Abishek J...Isles C	36146993	2022
36	Prospects of conservative treatment for Clostridium septicum-associated aortitis. ⁶²	Kirchweger P...Fugger R	35493338	2022
37	Cardiovascular Morbidity in Ankylosing Spondylitis: A Focus on Inflammatory Cardiac Disease. ⁶²	Bhattad PB...Roumia M	35795520	2022
38	An Atypical Presentation of Abdominal Aortic Aneurysm: A Cryptogenic Case of Aortitis. ⁶²	Maheswaranathan M...Kathleen Tarrant T	32804750	2022
39	A case of clostridium septicum aortitis. ⁶²	Ramkumar R...Qasabian R	34694691	2022
40	A man with fever and aortitis. ⁶²	Akazawa N...Ando M	35331596	2022
41	Mycotic pseudoaneurysm and aortitis caused by Candida sake. ⁶²	Fernandez Vecilla D...Diaz de Tuesta Del Arco JL	35718724	2022
42	Anterior spinal artery syndrome due to Clostridium septicum aortitis. ⁶²	Haidari Z...Tsagakis K	35711184	2022
43	The Role of Ultrasound and FDG-PET/CT to Detect Extracranial Artery Involvement in Patients with Suspected Large Vessel Vasculitis. ⁶²	Molina-Collada J...Alvaro-Gracia JM	35661221	2022
44	Tuberculosis Aortitis and Mycotic Pseudo-aneurysm of the Infra-renal Aorta after Intravesicular BCG Therapy. ⁶²	Gamble N...Harkin D	35722210	2022
45	COVID myocardial involvement presenting as left ventricular aneurysm and clot associated with normal coronary anatomy, deep vein thrombosis, and abnormal brachial artery flow-mediated dilatation. ⁶²	Tayal M...Walia R	35800475	2022
46	Syphilitic Aortitis. ⁶²	Miller SA...Ladich ER	35550616	2022
47	The Femoral Vein as a Long-Term Aorto-Iliac Graft for Aortic Infection and Aortitis. ⁶²	Eilenberg W...Neumayer C	35118519	2022
48	[A Case of Aortitis Caused by Pegfilgrastim Use during Neoadjuvant Chemotherapy for Treating Breast Cancer]. ⁶²	Nishimura M...Taguchi T	35578937	2022
49	Regression of IgG4-related coronary arteritis and aortitis with immunosuppressive therapy. ⁶²	Tse YH...Tse HF	35528130	2022
50	Emphysematous Aortitis. ⁶²	Traver EC...Gao NJ	35544389	2022

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Genes for Aortitis

Genes related to Aortitis (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CRP	C-Reactive Protein	Protein Coding	15.13	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
2	PRTN3	Proteinase 3	Protein Coding	6.4	DISEASES inferred ¹⁴
3	MPO	Myeloperoxidase	Protein Coding	5.95	DISEASES inferred ¹⁴
4	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	5.89	DISEASES inferred ¹⁴ ¹⁴
5	IL6	Interleukin 6	Protein Coding	5.66	DISEASES inferred ¹⁴
6	SRSF6	Serine And Arginine Rich Splicing Factor 6	Protein Coding	5.63	DISEASES inferred ¹⁴
7	ELN	Elastin	Protein Coding	5.56	DISEASES inferred ¹⁴
8	CD4	CD4 Molecule	Protein Coding	5.37	DISEASES inferred ¹⁴
9	TNF	Tumor Necrosis Factor	Protein Coding	5.31	DISEASES inferred ¹⁴
10	IL17A	Interleukin 17A	Protein Coding	5.28	DISEASES inferred ¹⁴
11	CSF3	Colony Stimulating Factor 3	Protein Coding	5.16	DISEASES inferred ¹⁴
12	EML2-AS1	EML2 Antisense RNA 1	RNA Gene	5.16	DISEASES inferred ¹⁴
13	IL1RN	Interleukin 1 Receptor Antagonist	Protein Coding	5.11	DISEASES inferred ¹⁴
14	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	5.08	DISEASES inferred ¹⁴
15	IFNG	Interferon Gamma	Protein Coding	5.05	DISEASES inferred ¹⁴
16	IL1B	Interleukin 1 Beta	Protein Coding	5.02	DISEASES inferred ¹⁴
17	FBN1	Fibrillin 1	Protein Coding	4.94	DISEASES inferred ¹⁴

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Variations for Aortitis

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Expression for Aortitis

Search GEO for disease gene expression data for Aortitis.

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Pathways for Aortitis

Pathways related to Aortitis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.91	CCR6 CD4 CRP CSF3 HLA-DRB1 IFNG
2	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.8	TNF IL6 IL1B IL17A FBN1 ELN
3	MIF Mediated Glucocorticoid Regulation ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ Overview of proinflammatory and profibrotic mediators ⁷⁴ PEDF Induced Signaling ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.61	TNF IL6 IL1RN IL1B IL17A IFNG
4	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.38	CCR6 CD4 CSF3 IL17A IL1B IL6
5	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.28	CCR6 CD4 CSF3 IL17A IL1B IL6
6	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.18	TNF PRTN3 IL6 IL1RN IL1B IL17A
7	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.61	TNF IL6 IL1B IL17A IFNG
8	NF-kappaB Signaling ³	12.58	TNF MPO IL1RN IL1B IL17A IFNG
9	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.55	CD4 IFNG IL17A IL1B IL6 MPO
10	Bacterial infections in CF airways ²² Show member pathways Altered glycosylation of MUC1 in tumor microenvironment ⁷⁴ IL-1 beta-dependent CFTR expression ²² IL1-mediated signaling events ⁶¹ Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²² NTHi-Induced Signaling ⁶⁴ Signal transduction through IL1R ⁷⁴	12.42	TNF IL6 IL1RN IL1B IFNG
11	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.3	TNF IL6 IL1B IFNG
12	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways "Mucin expression in CF via IL-6, IL-17 signaling pathways" ²² IL17 signaling pathway ⁶⁷ IL-17 signaling pathway ⁷⁴	12.27	TNF IL6 IL17A CSF3
13	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12.17	TNF IL6 IL1RN IL1B
14	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.17	TNF IL17A IFNG HLA-DRB1 CD4
15	Neuroinflammation and glutamatergic signaling ⁷⁴	12.11	TNF IL6 IL1B IFNG
16	Spinal cord injury ⁷⁴	12	IFNG IL1B IL6 TNF
17	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.97	TNF IL6 IL1B IL17A
18	Senescence and autophagy in cancer ⁷⁴	11.91	IL6 IL1B IFNG
19	Allograft rejection ⁷⁴	11.9	TNF IL1B IL17A IFNG HLA-DRB1
20	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.88	IL6 IL1B IL17A IFNG CD4
21	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.86	CD4 CSF3 IFNG IL6 MPO TNF
22	Cytokine production by Th17 cells in CF (Mouse model) ²² Show member pathways Cytokine production by Th17 cells in CF ²²	11.85	IL6 IL17A CSF3
23	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.8	IL6 HLA-DRB1 CRP CD4
24	C-MYB transcription factor network ⁶¹	11.78	PRTN3 MPO CD4
25	Activation of NF-KappaB by PKR ⁶⁴ Show member pathways Canonical NF-kB pathway ⁷⁴ Cellular Transformation by HTLV1 ⁶⁴ Inhibition of PKR ⁶⁶ STING pathway in Kawasaki-like disease and COVID-19 ⁷⁴	11.78	TNF IL1B IFNG
26	Burn wound healing ⁷⁴	11.78	TNF IL6 IL1B FBN1 ELN
27	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.76	TNF IL6 IFNG CRP
28	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.76	TNF IL6 IL1B IFNG CD4
29	Acute viral myocarditis ⁷⁴	11.75	IL6 IFNG CD4
30	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.73	TNF IL6 IL1B IL17A IFNG CD4
31	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.7	IFNG IL1B IL6 TNF
32	Th17 cell differentiation pathway ⁷⁴	11.69	IL6 IL1B IL17A IFNG CD4
33	IL 10 signaling pathway ⁶⁷	11.66	TNF IL6 IL1B
34	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.63	TNF IL6 IFNG
35	Lung fibrosis ⁷⁴	11.63	TNF IL6 IL1B ELN CSF3
36	"Non-genomic actions of 1,25 dihydroxyvitamin D3" ⁷⁴	11.56	TNF IL6 IFNG
37	THC Differentiation Pathway ⁶⁴	11.56	TNF IFNG HLA-DRB1 CD4
38	MSP-RON Signaling ⁶⁴	11.53	TNF IL1B IFNG
39	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.52	TNF IL6 IL1B IFNG
40	Interleukin-10 signaling ⁶⁶	11.44	TNF IL6 IL1RN IL1B CSF3
41	IL-10 Pathway ⁶⁴	11.38	TNF IL6 IL1B
42	Innate Lymphoid Cells Differentiation ⁶⁵	11.34	TNF IL1B IL17A IFNG CD4 CCR6
43	Prostaglandin signaling ⁷⁴	11.31	TNF IL6 IL1B IL17A
44	Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway ⁷⁴	11.3	TNF IL6 IL1B
45	Other interleukin signaling ⁶⁶	11.19	PRTN3 CSF3 CD4
46	Overview of nanoparticle effects ⁷⁴	11.08	TNF IL6 CRP
47	Development and heterogeneity of the ILC family ⁷⁴	11.06	TNF IL6 IL1B IL17A IFNG
48	G-protein signaling_Rap2B regulation pathway ²²	11.02	TNF IL6 IL1B IL17A FBN1 ELN
49	LDL Oxidation in Atherogenesis ⁶⁴	10.99	TNF MPO IL1B
50	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	10.79	IL6 IL1B

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GO Terms for Aortitis

Cellular components related to Aortitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	10.02	TNF PRTN3 MPO IL6 IL1RN IL1B
2	extracellular space	GO:0005615	9.7	CRP CSF3 FBN1 HLA-DRB1 IFNG IL17A

Biological processes related to Aortitis according to GeneCards Suite gene sharing:

(show all 31)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.48	CCR6 CD4 CSF3 FBN1 HLA-DRB1 IFNG
2	inflammatory response	GO:0006954	10.38	CRP IL17A IL1B IL1RN IL6 TNF
3	positive regulation of MAPK cascade	GO:0043410	10.25	TNF IL6 HLA-DRB1 CD4
4	positive regulation of DNA-binding transcription factor activity	GO:0051091	10.22	TNF IL6 IL1B CSF3
5	defense response to Gram-positive bacterium	GO:0050830	10.13	TNF IL6 IL1B IL17A CRP
6	positive regulation of phagocytosis	GO:0050766	10.12	TNF IL1B IFNG
7	positive regulation of interleukin-1 beta production	GO:0032731	10.11	TNF IL6 IL17A IFNG
8	positive regulation of nitric oxide biosynthetic process	GO:0045429	10.1	IFNG IL1B TNF
9	positive regulation of cytokine production involved in inflammatory response	GO:1900017	10.08	TNF IL6 IL17A
10	regulation of insulin secretion	GO:0050796	10.08	IFNG IL1B IL6 TNF
11	negative regulation of neurogenesis	GO:0050768	10.07	TNF IL6 IL1B
12	macrophage differentiation	GO:0030225	10.06	IFNG HLA-DRB1 CD4
13	positive regulation of osteoclast differentiation	GO:0045672	10.04	TNF IL17A IFNG
14	positive regulation of interleukin-6 production	GO:0032755	10.02	TNF IL6 IL1B IL17A IFNG
15	positive regulation of glial cell proliferation	GO:0060252	10.01	IL1B IL6 TNF
16	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	10	TNF IL1B IFNG
17	astrocyte activation	GO:0048143	9.97	TNF IL1B IFNG
18	positive regulation of interleukin-23 production	GO:0032747	9.95	IL17A IFNG
19	positive regulation of chemokine production	GO:0032722	9.95	TNF IL6 IL1B IFNG
20	negative regulation of interleukin-1-mediated signaling pathway	GO:2000660	9.94	IL6 IL1RN
21	positive regulation of fever generation	GO:0031622	9.93	TNF IL1B
22	positive regulation of neuroinflammatory response	GO:0150078	9.93	TNF IL6 IL1B
23	sequestering of triglyceride	GO:0030730	9.92	TNF IL1B
24	positive regulation of nitrogen compound metabolic process	GO:0051173	9.91	TNF IFNG
25	response to gold nanoparticle	GO:1990268	9.86	TNF MPO
26	positive regulation of vitamin D biosynthetic process	GO:0060557	9.85	TNF IFNG
27	negative regulation of lipid storage	GO:0010888	9.85	CRP IL6 TNF
28	humoral immune response	GO:0006959	9.85	CCR6 HLA-DRB1 IFNG IL6 TNF
29	vascular endothelial growth factor production	GO:0010573	9.73	TNF IL6 IL1B
30	immune response	GO:0006955	9.55	TNF IL6 IL1RN IL1B IL17A IFNG
31	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.43	TNF IL1B IFNG

Molecular functions related to Aortitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.47	TNF IL6 IL1RN IL1B IL17A IFNG

Sources

Sources for Aortitis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 24-Oct-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ART012 MIFTS: 43	Aortitis Categories: Cardiovascular diseases	Data Licensing For inquiries, contact: [email protected]
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