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MCID: ART012
MIFTS: 42

Aortitis

Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Aortitis

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MalaCards integrated aliases for Aortitis:

Name: Aortitis 12 44 15 17 71

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:519
MeSH 44 D001025
NCIt 50 C97085
SNOMED-CT 67 195368003
ICD10 32 I77.6 I79.1
UMLS 71 C0003509
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Summaries for Aortitis

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MalaCards based summary : Aortitis is related to takayasu arteritis and aortic valve insufficiency. An important gene associated with Aortitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include colon, heart and bone marrow, and related phenotype is immune system.

Wikipedia : 74 Aortitis is the inflammation of the aortic wall. The disorder is potentially life-threatening and rare.... more...

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Related Diseases for Aortitis

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Diseases related to Aortitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 897)
# Related Disease Score Top Affiliating Genes
1 takayasu arteritis 31.5 TNF PTX3 IL6 CRP
2 aortic valve insufficiency 31.4 SRSF6 ELN CRP
3 aortic dissection 30.9 IL6 ELN CRP
4 aortic disease 30.8 IL6 ELN CRP
5 cogan syndrome 30.7 PRTN3 CRP
6 hemopericardium 30.7 ELN CRP
7 cerebral aneurysms 30.6 IL6 ELN
8 endocarditis 30.5 TNF IL6 IL17A CRP
9 syphilis 30.5 PRTN3 IL17A CRP CD4
10 tertiary syphilis 30.4 TNF CRP CD4
11 anca-associated vasculitis 30.4 PRTN3 MPO
12 relapsing polychondritis 30.4 IL6 IL17A CRP
13 infective endocarditis 30.3 TNF IL6 IL17A CRP
14 aortic aneurysm, familial abdominal, 1 30.3 TNF IL6 IL1B ELN CRP
15 back pain 30.3 IL6 IL1RN IL1B
16 secondary syphilis 30.1 CRP CD4
17 tolosa-hunt syndrome 30.1 PRTN3 CRP
18 pericarditis 30.1 TNF IL6 IL1B CRP
19 carotid stenosis 30.0 TNF MPO CRP
20 pericardial effusion 30.0 PRTN3 IL6 CRP CD4
21 spondylitis 30.0 TNF IL6 IL1B IL17A CRP
22 pulmonary edema 30.0 TNF IL1B CRP
23 cardiogenic shock 30.0 TNF IL6
24 mediastinitis 30.0 MPO CRP CD4
25 subacute bacterial endocarditis 30.0 PRTN3 MPO CRP
26 rapidly progressive glomerulonephritis 29.9 PRTN3 MPO CRP
27 pyuria 29.9 PRTN3 IL6 CRP
28 asymptomatic neurosyphilis 29.9 IL17A CD4
29 q fever 29.8 TNF IL6 IL1B
30 cryoglobulinemia 29.8 TNF IL6 IL1B
31 coronary aneurysm 29.8 TNF IL6 CRP
32 pericardial tuberculosis 29.8 CRP CD4
33 diverticulitis 29.8 TNF IL6 CRP
34 obstructive jaundice 29.8 TNF IL6 CRP
35 spondyloarthropathy 1 29.8 TNF PRTN3 IL6 IL1RN IL17A CRP
36 spondyloarthropathy 29.8 TNF IL6 IL1B IL17A
37 sarcoidosis 1 29.8 TNF IL1RN IL1B CRP CD4
38 hyperthyroidism 29.8 PRTN3 IL6 CRP
39 vasculitis 29.7 TNF PTX3 PRTN3 MPO IL6 IL17A
40 arthropathy 29.7 TNF IL6 IL1B CRP
41 laryngitis 29.7 TNF IL6 IL1B CRP
42 facial paralysis 29.7 PRTN3 CRP CD4
43 endophthalmitis 29.7 TNF IL6 IL1B CRP
44 pancreatitis 29.7 TNF IL6 IL1B CRP
45 ileus 29.7 TNF IL6 IL1B CRP
46 typhoid fever 29.7 TNF IL6 IL1B CRP
47 pleural empyema 29.7 IL6 CRP CD4
48 scleritis 29.7 TNF PRTN3 MPO CRP
49 iga glomerulonephritis 29.7 PTX3 PRTN3 IL6
50 nocardiosis 29.7 TNF CRP CD4

Graphical network of the top 20 diseases related to Aortitis:



Diseases related to Aortitis
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Symptoms & Phenotypes for Aortitis

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MGI Mouse Phenotypes related to Aortitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.32 CD4 CRP IL17A IL1B IL1RN IL6
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Drugs & Therapeutics for Aortitis

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Aortitis and Retroperitoneal Fibrosis: Evaluation of Diagnostic Criteria Unknown status NCT03133949
2 VCRC Longitudinal Protocol for Aortitis Completed NCT03022331
3 Contrast Enhanced Ultrasound for Assessment of Carotid Artery Neovascularization as a Marker of Disease Activity in Takayasu's Arteritis and Giant Cell Arteritis Completed NCT01795456
4 VCRC Tissue Biorepository Collection Protocol Recruiting NCT02967068

Search NIH Clinical Center for Aortitis

Cochrane evidence based reviews: aortitis

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Genetic Tests for Aortitis

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Anatomical Context for Aortitis

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MalaCards organs/tissues related to Aortitis:

40
Colon, Heart, Bone Marrow, Eye, Brain, Thyroid, Skin
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Publications for Aortitis

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Articles related to Aortitis:

(show top 50) (show all 2210)
# Title Authors PMID Year
1
The pathology of Kawasaki disease aortitis: a study of 37 cases. 61
33144227 2021
2
Vasculitis beyond aortitis in IgG4-related disease (IgG4-RD): case report and review of the literature. 61
32710295 2021
3
Cardiovascular syphilis-associated acute myocardial infarction: A case report. 61
33607833 2021
4
Granulocyte colony stimulating factor-associated aortitis evaluated via multiple imaging modalities including vascular echography: a case report. 61
33598604 2021
5
Aortitis: recent advances, current concepts and future possibilities. 61
33593995 2021
6
Rupture of a heavily calcified aortic arch in a patient with aortitis syndrome, advanced atherosclerosis, and renal ischemia: a dilemma between appropriate blood pressure control and maintenance of renal perfusion. 61
32785880 2021
7
Clinically isolated descending thoracic aortitis in a healthy older woman: a diagnostic challenge. 61
33602759 2021
8
Unexpected Aortitis Mimicking an Ascending Aorta Intramural Hematoma in Ankylosing Spondylitis. 61
33356356 2021
9
The enigmatic immunoglobulin G4-related disease and its varied cardiovascular manifestations. 61
33468575 2021
10
Successful treatment of G-CSF-related aortitis with prednisolone during preoperative chemotherapy for breast cancer: a case report. 61
33443626 2021
11
Aortic dissection during pregnancy and puerperium: A Japanese nationwide survey. 61
33480070 2021
12
Scleritis and Aortitis in Early Rheumatoid Arthritis. 61
33492029 2021
13
Medium- and Large-Vessel Vasculitis. 61
33464968 2021
14
Aortitis: an update. 61
33186247 2021
15
Paraneoplastic aortitis in a patient with relapsed multiple myeloma successfully treated with daratumumab, bortezomib and dexamethasone. 61
33404692 2021
16
Thoracic Cardiovascular Complications of Tuberculosis. 61
33475319 2021
17
Management of Descending Thoracic Aortic Diseases: Similarities and Differences Among Cardiovascular Guidelines. 61
33435805 2021
18
Phenotyping of IgG4-related diseases based on affected organ pattern: A multicenter cohort study using cluster analysis. 61
31902317 2021
19
Custom-made endograft with left subclavian artery branch in a patient with Takayasu aortitis complicated by type-B dissection and inflammatory involvement of the epiaortic vessels. 61
33236120 2021
20
Brucellosis aortitis: An interesting case. 61
33483969 2021
21
Aortitis - An Interdisciplinary Challenge. 61
33402448 2021
22
Aortitis masquerading as intramural hematoma: When to observe, when to operate? A case report. 61
33502772 2021
23
Granulocyte Colony-Stimulating Factor-Associated Aortitis: Treatment Suggestion for This Complication. 61
32644903 2021
24
Symptomatic aortitis at giant cell arteritis diagnosis: a prognostic factor of aortic event. 61
33413605 2021
25
Vasculitis and aortitis: COVID-19 challenging complications. 61
32889075 2021
26
One Giant Step for Giant Cell Arteritis: Updates in Diagnosis and Treatment. 61
33488050 2021
27
Etiology, Diagnosis and Management of Aortitis. 61
32390100 2020
28
Role of MRI in the Evaluation of Thoracoabdominal Emergencies. 61
33264275 2020
29
Overview of IgG4-related aortitis and periaortitis. A decade since their first description. 61
33121641 2020
30
[Syncope, pain in the large joints, and painful swelling of the right eye in a 51-year-old patient : Pitfalls in the diagnosis and treatment of a rare disease]. 61
33001239 2020
31
The complex interplay among atherosclerosis, inflammation, and degeneration in ascending thoracic aortic aneurysms. 61
31706551 2020
32
Unexpected increase of aortic stiffness in juvenile Spondyloarthropathies. 61
32938508 2020
33
Bilateral Hydronephrosis From Retroperitoneal Fibrosis. 61
33489559 2020
34
Correction to: Etiology, Diagnosis and Management of Aortitis. 61
32494831 2020
35
Giant cell aortitis masquerading as intramural hematoma. 61
33294756 2020
36
Treatment-resistant cough: a rare manifestation of IgG4-related disease involving the larynx. 61
33229485 2020
37
[Hybrid Two-stage Repair of Syphilitic Aortic Aneurysm, Total Arch Replacement and Thoracic Endovascular Aortic Repair;Report of a Case]. 61
33268755 2020
38
Granulocyte Colony-Stimulating Factor-Induced Aortitis with Lung Injury, Splenomegaly, and a Rash During Treatment for Recurrent Extraosseous Mucinous Chondrosarcoma. 61
33191326 2020
39
Non-Infectious, Necrotizing and Granulomatous Aortitis in a Female Gorilla. 61
33288155 2020
40
Tularemia: A Case Series of Patients Diagnosed at the National Reference Center for Rickettsioses From 2008 to 2017. 61
33209946 2020
41
Florid aortitis following SARS-CoV-2 infection. 61
32766701 2020
42
Endovascular aortic aneurysm repair to facilitate computed tomography-guided biopsy and aid diagnosis in a case of presumed immunoglobulin G4 aortitis. 61
32267992 2020
43
Aortitis: a simulator of intramural aortic hematoma. 61
33160888 2020
44
Mycotic Aneurysm Rupture Due to Clostridium septicum Thoracic Aortitis. 61
33208291 2020
45
Capnocytophaga canimorsus Aortitis in an Immunocompetent Host. 61
33205049 2020
46
Lupus Aortitis Successfully Treated with Moderate-dose Glucocorticoids: A Case Report and Review of the Literature. 61
32641654 2020
47
Emphysematous abdominal aortitis: a hint of Salmonella infection. 61
33230643 2020
48
Giant Cell Aortitis Mimicking Aortic Intramural Hematoma. 61
32599053 2020
49
The comeback of syphilitic aortitis. 61
32580086 2020
50
[The current place of non-invasive large-vessel imaging in the diagnosis and follow-up of giant cell arteritis]. 61
32674899 2020
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Variations for Aortitis

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Expression for Aortitis

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Search GEO for disease gene expression data for Aortitis.
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Pathways for Aortitis

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Pathways related to Aortitis according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.95 TNF PTX3 PRTN3 MPO IL6 IL1RN
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.29 TNF PRTN3 IL6 IL1RN IL1B IL17A
3
Allograft rejection 36 1
Show member pathways
 12.79 TNF IL6 IL1B IL17A CD4
4
T cell receptor signaling pathway 36
Show member pathways
 12.54 TNF IL6 IL1B IL17A CD4
5
Th17 cell differentiation 36
Show member pathways
 12.53 TNF IL6 IL1B IL17A CD4
6
NF-kappaB Signaling 4
12.49 TNF MPO IL1RN IL1B IL17A
7
Immune response IL-23 signaling pathway 23
Show member pathways
 12.38 TNF MPO IL6 IL1B IL17A CD4
8
IL-17 Family Signaling Pathways 64
Show member pathways
 12.28 TNF IL6 IL1B IL17A
9
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.2 TNF IL6 IL1B IL17A
10
Folate Metabolism 1
Show member pathways
 12.16 TNF MPO IL6 IL1B CRP
11
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.13 TNF IL6 IL1RN IL1B
12
Yersinia infection 36
12.02 TNF IL6 IL1B CD4
13
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.92 TNF MPO IL6 CD4
14
TNF signaling pathway 36
11.91 TNF IL6 IL1B
15
Interleukin-4 and 13 signaling 65
11.91 TNF IL6 IL1B IL17A
16
Amoebiasis 36
11.86 TNF IL6 IL1B
17
AGE-RAGE signaling pathway in diabetic complications 36
11.85 TNF IL6 IL1B
18
Hematopoietic cell lineage 36
11.83 TNF IL6 IL1B CD4
19
Rheumatoid arthritis 36
11.79 TNF IL6 IL1B IL17A
20
Th17 Differentiation Pathway 64
Show member pathways
 11.77 IL6 IL1B IL17A CD4
21
C-MYB transcription factor network 1
11.74 PRTN3 MPO CD4
22
Pertussis 36
11.72 TNF IL6 IL1B
23
Innate Lymphoid Cell Differentiation Pathways 64
11.68 TNF IL1B IL17A CD4
24
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.63 TNF IL6 IL1B
25
Legionellosis 36
11.57 TNF IL6 IL1B
26
Dendritic Cells Developmental Lineage Pathway 64
11.57 TNF IL6 IL1B CD4
27
Malaria 36
11.51 TNF IL6 IL1B
28
amb2 Integrin signaling 1
11.49 TNF MPO IL6
29
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.45 TNF IL6 IL1B
30
African trypanosomiasis 36
11.36 TNF IL6 IL1B
31
IL-10 Pathway 63
11.32 TNF IL6 IL1B
32
Interleukin-10 signaling 65
11.31 TNF IL6 IL1RN IL1B
33
Antifolate resistance 36
11.23 TNF IL6 IL1B
34
Th1 Differentiation Pathway 64
Show member pathways
 11.23 TNF IL6 IL1B IL17A CD4
35
Development and heterogeneity of the ILC family 1
11.06 TNF IL6 IL1B IL17A
36
G-protein signaling_Rap2B regulation pathway 23
10.96 TNF IL6 IL1B IL17A ELN
37
Overview of nanoparticle effects 1
10.95 TNF IL6 CRP
38
Cytokines and Inflammatory Response 1
10.92 TNF IL6 IL1B CD4
39
LDL Oxidation in Atherogenesis 63
10.84 TNF MPO IL1B
40
Lung fibrosis 1
10.82 TNF PTX3 IL6 IL1B ELN
41
IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
10.75 IL6 IL1B
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GO Terms for Aortitis

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Cellular components related to Aortitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 TNF PTX3 PRTN3 MPO IL6 IL1RN
2 extracellular region GO:0005576 9.32 TNF PTX3 PRTN3 MPO IL6 IL1RN

Biological processes related to Aortitis according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.91 TNF IL6 IL1RN IL1B IL17A CD4
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.82 TNF IL6 IL1B
3 defense response to Gram-negative bacterium GO:0050829 9.81 IL6 IL17A CD4
4 regulation of insulin secretion GO:0050796 9.8 TNF IL6 IL1B
5 response to glucocorticoid GO:0051384 9.79 TNF IL6 IL1RN
6 positive regulation of T cell proliferation GO:0042102 9.78 IL6 IL1B CD4
7 positive regulation of interleukin-8 production GO:0032757 9.77 TNF IL6 IL1B
8 positive regulation of interleukin-1 beta production GO:0032731 9.77 TNF IL6 IL17A
9 defense response to Gram-positive bacterium GO:0050830 9.76 TNF IL6 IL17A CRP
10 positive regulation of phagocytosis GO:0050766 9.75 TNF PTX3 IL1B
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.71 TNF PTX3 IL1B
12 positive regulation of interleukin-6 production GO:0032755 9.71 TNF IL6 IL1B IL17A
13 acute-phase response GO:0006953 9.7 IL6 IL1RN CRP
14 negative regulation of neurogenesis GO:0050768 9.67 TNF IL6 IL1B
15 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 TNF IL1B
16 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.65 TNF IL1B
17 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.65 TNF IL6 IL17A
18 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.64 TNF IL6
19 regulation of establishment of endothelial barrier GO:1903140 9.63 TNF IL1B
20 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.62 IL6 IL1RN
21 opsonization GO:0008228 9.62 PTX3 CRP
22 positive regulation of fever generation GO:0031622 9.58 TNF IL1B
23 negative regulation by host of viral process GO:0044793 9.57 PTX3 CRP
24 sequestering of triglyceride GO:0030730 9.56 TNF IL1B
25 response to yeast GO:0001878 9.55 PTX3 MPO
26 positive regulation of glial cell proliferation GO:0060252 9.54 TNF IL6 IL1B
27 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.51 TNF IL1B
28 positive regulation of neuroinflammatory response GO:0150078 9.5 TNF IL6 IL1B
29 inflammatory response GO:0006954 9.5 TNF PTX3 IL6 IL1RN IL1B IL17A
30 negative regulation of lipid storage GO:0010888 9.43 TNF IL6 CRP
31 vascular endothelial growth factor production GO:0010573 9.33 TNF IL6 IL1B
32 cytokine-mediated signaling pathway GO:0019221 9.17 TNF PRTN3 IL6 IL1RN IL1B IL17A

Molecular functions related to Aortitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 9.26 IL1RN IL1B
2 virion binding GO:0046790 9.16 PTX3 CRP
3 cytokine activity GO:0005125 9.02 TNF IL6 IL1RN IL1B IL17A
4 complement component C1q binding GO:0001849 8.96 PTX3 CRP
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Sources for Aortitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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