MCID: ART012
MIFTS: 43

Aortitis

Categories: Cardiovascular diseases
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Aliases & Classifications for Aortitis

Summaries for Aortitis

MalaCards based summary: Aortitis is related to takayasu arteritis and aortic atherosclerosis. An important gene associated with Aortitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include heart, colon and bone marrow, and related phenotypes are immune system and cardiovascular system

Wikipedia: 75 Aortitis is the inflammation of the aortic wall. The disorder is potentially life-threatening and rare.... more...

Related Diseases for Aortitis

Diseases related to Aortitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1144)
# Related Disease Score Top Affiliating Genes
1 takayasu arteritis 32.2 TNF IL6 HLA-DRB1 CRP
2 aortic atherosclerosis 31.3 TNF IL6 IL1B CRP
3 aortic valve insufficiency 31.1 SRSF6 FBN1 ELN CRP
4 igg4-related disease 30.8 PRTN3 MPO CRP CD4 CCR6
5 aortic dissection 30.7 IL6 FBN1 ELN CRP
6 angina pectoris 30.7 TNF IL6 CRP
7 cogan syndrome 30.7 TNF PRTN3 CRP
8 infective endocarditis 30.7 PRTN3 MPO IL6 CRP CCR6
9 aortic valve disease 2 30.6 FBN1 ELN CRP
10 interstitial keratitis 30.5 TNF PRTN3 CRP
11 tertiary syphilis 30.5 TNF PRTN3 CRP CD4
12 aortic aneurysm 30.4 TNF IL6 IL1B FBN1 ELN CRP
13 vascular disease 30.3 TNF MPO IL6 FBN1 ELN CRP
14 neutrophilia, hereditary 30.3 MPO IL6 CSF3 CRP
15 endocarditis 30.3 TNF IL6 IL17A IFNG CRP
16 mitral valve insufficiency 30.2 FBN1 ELN CRP
17 secondary syphilis 30.2 TNF CRP CD4
18 hemopericardium 30.2 FBN1 CRP
19 pericardial effusion 30.2 TNF IL6 CRP CD4
20 reactive arthritis 30.1 TNF PRTN3 IL17A CRP CCR6
21 iga glomerulonephritis 30.1 PRTN3 IL6 CCR6
22 syphilis 30.1 TNF PRTN3 IL17A HLA-DRB1 CRP CD4
23 gas gangrene 30.1 TNF IL6 CRP
24 serum amyloid a amyloidosis 30.1 TNF IL6 CRP
25 limb ischemia 30.0 IL6 CSF3 CRP
26 purulent endophthalmitis 30.0 CRP CD4
27 mediastinitis 29.9 MPO IL6 CRP CD4
28 subacute bacterial endocarditis 29.9 PRTN3 MPO CRP
29 splenic infarction 29.9 PRTN3 MPO CRP
30 polyarteritis nodosa 29.9 TNF PRTN3 MPO IL6 HLA-DRB1 CRP
31 acalculous cholecystitis 29.9 CRP CD4
32 pyuria 29.9 PRTN3 IL6 CRP
33 tolosa-hunt syndrome 29.9 PRTN3 CRP
34 pleural empyema 29.9 IL6 CRP CD4
35 autoimmune pancreatitis 29.9 CRP CD4 CCR6
36 inflammatory bowel disease 1 29.9 TNF IL6 IL1B IL17A CCR6
37 aortic aneurysm, familial thoracic 1 29.8 TNF IL6 IL1B FBN1 ELN CRP
38 haemophilus influenzae 29.8 TNF IL1B
39 nocardiosis 29.8 TNF CRP CD4
40 granulocytopenia 29.8 MPO CSF3
41 peripheral vascular disease 29.8 TNF IL6 IL1B CRP
42 aortic disease 29.8 TNF IL6 IL1B FBN1 ELN CRP
43 subclavian artery aneurysm 29.8 FBN1 ELN
44 vasculitis 29.7 TNF PRTN3 MPO IL6 IL1B IL17A
45 aortic aneurysm, familial abdominal, 1 29.7 TNF IL6 IL1B FBN1 ELN CRP
46 kawasaki disease 29.7 TNF ELN CRP
47 diverticulitis 29.7 TNF IL6 CRP CCR6
48 pulmonary artery disease 29.7 TNF IL6 CRP CCR6
49 back pain 29.7 IL6 IL1RN IL1B CRP
50 hyperthyroidism 29.7 TNF PRTN3 IL6 CRP

Graphical network of the top 20 diseases related to Aortitis:



Diseases related to Aortitis

Symptoms & Phenotypes for Aortitis

MGI Mouse Phenotypes related to Aortitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.07 CCR6 CD4 CRP CSF3 FBN1 IFNG
2 cardiovascular system MP:0005385 10.02 CCR6 CRP ELN FBN1 IFNG IL1B
3 skeleton MP:0005390 9.81 ELN FBN1 HLA-DRB1 IFNG IL17A IL1B
4 hematopoietic system MP:0005397 9.73 CCR6 CD4 CSF3 FBN1 IFNG IL17A
5 integument MP:0010771 9.28 CD4 CSF3 FBN1 IFNG IL17A IL1B

Drugs & Therapeutics for Aortitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Aortitis and Retroperitoneal Fibrosis: Evaluation of Diagnostic Criteria Unknown status NCT03133949
2 VCRC Longitudinal Protocol for Aortitis Completed NCT03022331
3 Contrast Enhanced Ultrasound for Assessment of Carotid Artery Neovascularization as a Marker of Disease Activity in Takayasu's Arteritis and Giant Cell Arteritis Completed NCT01795456
4 VCRC Tissue Biorepository Collection Protocol Recruiting NCT02967068

Search NIH Clinical Center for Aortitis

Cochrane evidence based reviews: aortitis

Genetic Tests for Aortitis

Anatomical Context for Aortitis

Organs/tissues related to Aortitis:

MalaCards : Heart, Colon, Bone Marrow, Spinal Cord, Breast, Lung, Liver

Publications for Aortitis

Articles related to Aortitis:

(show top 50) (show all 2385)
# Title Authors PMID Year
1
The Great Masquerader: Coronary Occlusion From Thrombus in Ascending Aortic Aneurysm Causing Anterior-Wall STEMI With Cardiogenic Shock. 62
36200998 2022
2
Long-Term Clinical and Radiographic Outcomes in Patients With Clinically Isolated Aortitis. 62
36250477 2022
3
Cardiac arrest caused by ruptured nonaneurysmal infectious aortitis. 62
36260217 2022
4
Infectious aortitis complicating ruptured mycotic aneurysm due to Aeromonas sobria bacteremia. 62
36037846 2022
5
Reversal of IgG4-related aortitis after treatment evidenced by [18F]FDG PET/CT. 62
36129564 2022
6
[Aortic Root Pseudoaneurysm]. 62
36155567 2022
7
[Emergency Operation for Impending Rupture of Syphilitic Aortic Aneurysm with Left Coronary Ostial Stenosis:Report of a Case]. 62
36156517 2022
8
Varicella zoster virus and cardiovascular diseases. 62
36128930 2022
9
The role of PET/CT in large vessel vasculitis and related disorders: diagnosis, extent evaluation and assessment of therapy response. 62
36066110 2022
10
Fully integrated [18F]FDG PET/MR in large vessel vasculitis. 62
31602964 2022
11
Granulocyte colony-stimulating factor-associated aortitis in a woman with breast cancer: a case report. 62
35980544 2022
12
Inflammatory Diseases of the Aorta: JACC Focus Seminar, Part 2. 62
35981827 2022
13
A Case of Seronegative Primary Sjögren's Syndrome Complicated by Takayasu Arteritis in a Japanese Girl. 62
35953299 2022
14
Giant cell arteritis-related stroke in a large inception cohort: A comparative study. 62
35512621 2022
15
Emergent Magnetic Resonance Angiography for Evaluation of the Thoracoabdominal and Peripheral Vasculature. 62
35995474 2022
16
Inflammatory Thoracic Aortic Aneurysm in a Patient with Advanced Lung Adenocarcinoma Treated with Pembrolizumab. 62
35022350 2022
17
Aortitis presenting as acute myeloid leukemia - A case report. 62
36045831 2022
18
ANCA-associated vasculitis and IgG4-related disease overlap syndrome: a case report and literature review. 62
35449491 2022
19
Single-Center Analysis of Pegfilgrastim-induced Aortitis Using a Drug Prescription Database and CT Findings. 62
35943335 2022
20
Global Transcriptomic Profiling Identifies Differential Gene Expression Signatures Between Inflammatory and Noninflammatory Aortic Aneurysms. 62
35403833 2022
21
High risk and low prevalence diseases: Giant cell arteritis. 62
35688119 2022
22
Whipple's aortitis. 62
35078215 2022
23
Multiple Anastomotic Dehiscences After the Bentall Procedure for Aortitis Syndrome. 62
36038468 2022
24
Pegfilgrastim-induced Aortitis: Cardiovascular Diagnosis in the Oncologic Setting. 62
35943341 2022
25
Systematic literature review and meta-analysis of Clostridium septicum aortitis. 62
35358668 2022
26
Tuberculosis and Cardiovascular Complications: An Overview. 62
36158349 2022
27
Immunoglobulin G4-related coronary periarteritis: a systematic literature review with a case series. 62
35445950 2022
28
A case report of recurrent acute myocardial infarction and cardiac arrest due to aortic dissection secondary to IgG4-related aortitis. 62
35143994 2022
29
Porto-Sinusoidal Vascular Disease in a Patient With Diffuse Aortitis and Massive Ascites. 62
35811580 2022
30
Infectious aortitis from pyogenic spondylitis and psoas abscess: Case report. 62
35775686 2022
31
[Sweet syndrome of childhood with acquired cutis laxa (Marshall syndrome) as primary manifestation of Takayasu arteritis]. 62
35925217 2022
32
Takayasu's Arteritis With Acute Severe Aortic Regurgitation Requiring a Bio-Bentall Procedure. 62
35989796 2022
33
Retrospective multicentric study comparing infectious and non-infectious aortitis. 62
35792621 2022
34
Recent advances in the diagnosis and therapy of large vessel vasculitis. 62
35699647 2022
35
Unexplained chest pain in a patient with giant cell arteritis? Think aortic dissection. 62
36146993 2022
36
Prospects of conservative treatment for Clostridium septicum-associated aortitis. 62
35493338 2022
37
Cardiovascular Morbidity in Ankylosing Spondylitis: A Focus on Inflammatory Cardiac Disease. 62
35795520 2022
38
An Atypical Presentation of Abdominal Aortic Aneurysm: A Cryptogenic Case of Aortitis. 62
32804750 2022
39
A case of clostridium septicum aortitis. 62
34694691 2022
40
A man with fever and aortitis. 62
35331596 2022
41
Mycotic pseudoaneurysm and aortitis caused by Candida sake. 62
35718724 2022
42
Anterior spinal artery syndrome due to Clostridium septicum aortitis. 62
35711184 2022
43
The Role of Ultrasound and FDG-PET/CT to Detect Extracranial Artery Involvement in Patients with Suspected Large Vessel Vasculitis. 62
35661221 2022
44
Tuberculosis Aortitis and Mycotic Pseudo-aneurysm of the Infra-renal Aorta after Intravesicular BCG Therapy. 62
35722210 2022
45
COVID myocardial involvement presenting as left ventricular aneurysm and clot associated with normal coronary anatomy, deep vein thrombosis, and abnormal brachial artery flow-mediated dilatation. 62
35800475 2022
46
Syphilitic Aortitis. 62
35550616 2022
47
The Femoral Vein as a Long-Term Aorto-Iliac Graft for Aortic Infection and Aortitis. 62
35118519 2022
48
[A Case of Aortitis Caused by Pegfilgrastim Use during Neoadjuvant Chemotherapy for Treating Breast Cancer]. 62
35578937 2022
49
Regression of IgG4-related coronary arteritis and aortitis with immunosuppressive therapy. 62
35528130 2022
50
Emphysematous Aortitis. 62
35544389 2022

Variations for Aortitis

Expression for Aortitis

Search GEO for disease gene expression data for Aortitis.

Pathways for Aortitis

Pathways related to Aortitis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 CCR6 CD4 CRP CSF3 HLA-DRB1 IFNG
2
Show member pathways
13.8 TNF IL6 IL1B IL17A FBN1 ELN
3
Show member pathways
13.61 TNF IL6 IL1RN IL1B IL17A IFNG
4
Show member pathways
13.38 CCR6 CD4 CSF3 IL17A IL1B IL6
5
Show member pathways
13.28 CCR6 CD4 CSF3 IL17A IL1B IL6
6
Show member pathways
13.18 TNF PRTN3 IL6 IL1RN IL1B IL17A
7
Show member pathways
12.61 TNF IL6 IL1B IL17A IFNG
8 12.58 TNF MPO IL1RN IL1B IL17A IFNG
9
Show member pathways
12.55 CD4 IFNG IL17A IL1B IL6 MPO
10
Show member pathways
12.42 TNF IL6 IL1RN IL1B IFNG
11
Show member pathways
12.3 TNF IL6 IL1B IFNG
12
Show member pathways
12.27 TNF IL6 IL17A CSF3
13 12.17 TNF IL6 IL1RN IL1B
14
Show member pathways
12.17 TNF IL17A IFNG HLA-DRB1 CD4
15 12.11 TNF IL6 IL1B IFNG
16 12 IFNG IL1B IL6 TNF
17 11.97 TNF IL6 IL1B IL17A
18 11.91 IL6 IL1B IFNG
19 11.9 TNF IL1B IL17A IFNG HLA-DRB1
20
Show member pathways
11.88 IL6 IL1B IL17A IFNG CD4
21 11.86 CD4 CSF3 IFNG IL6 MPO TNF
22
Show member pathways
11.85 IL6 IL17A CSF3
23
Show member pathways
11.8 IL6 HLA-DRB1 CRP CD4
24 11.78 PRTN3 MPO CD4
25
Show member pathways
11.78 TNF IL1B IFNG
26 11.78 TNF IL6 IL1B FBN1 ELN
27 11.76 TNF IL6 IFNG CRP
28 11.76 TNF IL6 IL1B IFNG CD4
29 11.75 IL6 IFNG CD4
30
Show member pathways
11.73 TNF IL6 IL1B IL17A IFNG CD4
31
Show member pathways
11.7 IFNG IL1B IL6 TNF
32 11.69 IL6 IL1B IL17A IFNG CD4
33 11.66 TNF IL6 IL1B
34
Show member pathways
11.63 TNF IL6 IFNG
35 11.63 TNF IL6 IL1B ELN CSF3
36 11.56 TNF IL6 IFNG
37 11.56 TNF IFNG HLA-DRB1 CD4
38 11.53 TNF IL1B IFNG
39 11.52 TNF IL6 IL1B IFNG
40 11.44 TNF IL6 IL1RN IL1B CSF3
41 11.38 TNF IL6 IL1B
42 11.34 TNF IL1B IL17A IFNG CD4 CCR6
43 11.31 TNF IL6 IL1B IL17A
44 11.3 TNF IL6 IL1B
45 11.19 PRTN3 CSF3 CD4
46 11.08 TNF IL6 CRP
47 11.06 TNF IL6 IL1B IL17A IFNG
48 11.02 TNF IL6 IL1B IL17A FBN1 ELN
49 10.99 TNF MPO IL1B
50 10.79 IL6 IL1B

GO Terms for Aortitis

Cellular components related to Aortitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.02 TNF PRTN3 MPO IL6 IL1RN IL1B
2 extracellular space GO:0005615 9.7 CRP CSF3 FBN1 HLA-DRB1 IFNG IL17A

Biological processes related to Aortitis according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.48 CCR6 CD4 CSF3 FBN1 HLA-DRB1 IFNG
2 inflammatory response GO:0006954 10.38 CRP IL17A IL1B IL1RN IL6 TNF
3 positive regulation of MAPK cascade GO:0043410 10.25 TNF IL6 HLA-DRB1 CD4
4 positive regulation of DNA-binding transcription factor activity GO:0051091 10.22 TNF IL6 IL1B CSF3
5 defense response to Gram-positive bacterium GO:0050830 10.13 TNF IL6 IL1B IL17A CRP
6 positive regulation of phagocytosis GO:0050766 10.12 TNF IL1B IFNG
7 positive regulation of interleukin-1 beta production GO:0032731 10.11 TNF IL6 IL17A IFNG
8 positive regulation of nitric oxide biosynthetic process GO:0045429 10.1 IFNG IL1B TNF
9 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.08 TNF IL6 IL17A
10 regulation of insulin secretion GO:0050796 10.08 IFNG IL1B IL6 TNF
11 negative regulation of neurogenesis GO:0050768 10.07 TNF IL6 IL1B
12 macrophage differentiation GO:0030225 10.06 IFNG HLA-DRB1 CD4
13 positive regulation of osteoclast differentiation GO:0045672 10.04 TNF IL17A IFNG
14 positive regulation of interleukin-6 production GO:0032755 10.02 TNF IL6 IL1B IL17A IFNG
15 positive regulation of glial cell proliferation GO:0060252 10.01 IL1B IL6 TNF
16 positive regulation of membrane protein ectodomain proteolysis GO:0051044 10 TNF IL1B IFNG
17 astrocyte activation GO:0048143 9.97 TNF IL1B IFNG
18 positive regulation of interleukin-23 production GO:0032747 9.95 IL17A IFNG
19 positive regulation of chemokine production GO:0032722 9.95 TNF IL6 IL1B IFNG
20 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.94 IL6 IL1RN
21 positive regulation of fever generation GO:0031622 9.93 TNF IL1B
22 positive regulation of neuroinflammatory response GO:0150078 9.93 TNF IL6 IL1B
23 sequestering of triglyceride GO:0030730 9.92 TNF IL1B
24 positive regulation of nitrogen compound metabolic process GO:0051173 9.91 TNF IFNG
25 response to gold nanoparticle GO:1990268 9.86 TNF MPO
26 positive regulation of vitamin D biosynthetic process GO:0060557 9.85 TNF IFNG
27 negative regulation of lipid storage GO:0010888 9.85 CRP IL6 TNF
28 humoral immune response GO:0006959 9.85 CCR6 HLA-DRB1 IFNG IL6 TNF
29 vascular endothelial growth factor production GO:0010573 9.73 TNF IL6 IL1B
30 immune response GO:0006955 9.55 TNF IL6 IL1RN IL1B IL17A IFNG
31 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 TNF IL1B IFNG

Molecular functions related to Aortitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.47 TNF IL6 IL1RN IL1B IL17A IFNG

Sources for Aortitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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