MCID: ART012
MIFTS: 33

Aortitis

Categories: Cardiovascular diseases

Aliases & Classifications for Aortitis

Summaries for Aortitis

MalaCards based summary : Aortitis is related to spondyloarthropathy 1 and temporal arteritis. An important gene associated with Aortitis is CRP (C-Reactive Protein). The drugs rituximab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include heart, colon and thyroid.

Wikipedia : 77 Aortitis is the inflammation of the aortic wall. The disorder is potentially life-threatening and rare.... more...

Related Diseases for Aortitis

Diseases related to Aortitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 195)
# Related Disease Score Top Affiliating Genes
1 spondyloarthropathy 1 30.4 CRP MRAP
2 temporal arteritis 30.3 CDK9 CRP
3 vasculitis 30.3 CRP MPO
4 polyarteritis nodosa 29.7 CRP MPO
5 ulcerative colitis 29.6 CRP MPO
6 appendicitis 29.4 CRP MPO
7 pneumonia 29.2 CRP MPO
8 igg4-related aortitis 12.2
9 takayasu arteritis 11.6
10 aortic aneurysm 10.5
11 aortic valve insufficiency 10.4
12 endocarditis 10.4
13 discitis 10.2 CRP MRAP
14 pyuria 10.2 CRP MRAP
15 tenosynovitis 10.2 CRP MRAP
16 bursitis 10.2 CRP MRAP
17 tendinitis 10.2 CRP MRAP
18 spondylitis 10.2
19 mesenteric lymphadenitis 10.2 CRP MRAP
20 renal tuberculosis 10.2 CRP MRAP
21 arthritis 10.2
22 crohn's disease 10.2
23 central nervous system vasculitis 10.2 CDK9 CRP
24 relapsing polychondritis 10.2
25 palindromic rheumatism 10.2 CRP MRAP
26 myocardial infarction 10.2
27 ochronosis 10.2 MRAP NT5C1B
28 bone inflammation disease 10.1 CRP MRAP
29 rheumatoid arthritis 10.1
30 aortic aneurysm, familial thoracic 1 10.1
31 renovascular hypertension 10.1
32 syphilis 10.1
33 aortic aneurysm, familial abdominal, 1 10.1
34 systemic lupus erythematosus 10.1
35 cogan syndrome 10.1
36 igg4-related disease 10.1
37 adenocarcinoma 10.1
38 coronary stenosis 10.1
39 lupus erythematosus 10.1
40 aortic coarctation 10.1
41 colitis 10.1
42 retroperitoneal fibrosis 10.1
43 aortic valve disease 1 10.0 CRP MRAP
44 mononeuritis multiplex 10.0 CRP MPO
45 infective endocarditis 10.0
46 pulmonary tuberculosis 10.0
47 rapidly progressive glomerulonephritis 10.0 CRP MPO
48 pulmonary aspergilloma 10.0 CRP MPO
49 hypersensitivity vasculitis 10.0 CRP MPO
50 hypersensitivity reaction type iii disease 10.0 CRP MPO

Graphical network of the top 20 diseases related to Aortitis:



Diseases related to Aortitis

Symptoms & Phenotypes for Aortitis

Drugs & Therapeutics for Aortitis

Drugs for Aortitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
2 Antineoplastic Agents, Immunological Phase 1, Phase 2
3 Antirheumatic Agents Phase 1, Phase 2
4 Immunologic Factors Phase 1, Phase 2
5 Immunoglobulin G Phase 1, Phase 2
6 Immunoglobulins Phase 1, Phase 2
7 Antibodies Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Tocilizumab Dose-tapering and Interruption in Patients With Giant Cell Arteritis Achieving the Clinical Remission. Recruiting NCT03244709 Phase 4 Tocilizumab
2 Rituximab in IgG4-RD: A Phase 1-2 Trial Completed NCT01584388 Phase 1, Phase 2 Rituximab
3 Carotid Artery Neovascularization in Takayasu's and Giant Cell Arteritis Completed NCT01795456
4 VCRC Longitudinal Protocol for Aortitis Recruiting NCT03022331
5 Aortitis and Retroperitoneal Fibrosis: Evaluation of Diagnostic Criteria Recruiting NCT03133949
6 VCRC Tissue Repository Recruiting NCT02967068

Search NIH Clinical Center for Aortitis

Cochrane evidence based reviews: aortitis

Genetic Tests for Aortitis

Anatomical Context for Aortitis

MalaCards organs/tissues related to Aortitis:

42
Heart, Colon, Thyroid, Kidney, Bone, Pituitary, Liver

Publications for Aortitis

Articles related to Aortitis:

(show top 50) (show all 951)
# Title Authors Year
1
Aortic angiosarcoma masquerading as inflammatory aortitis. ( 30943140 )
2019
2
Infectious Aortitis with Abdominal Aortic Aneurysm in a 47-Year-Old Female with Systemic Lupus Erythematosus. ( 31089427 )
2019
3
A Case of IBD Immunosuppression Related Salmonella Aortitis Requiring Emergency Vascular Grafting. ( 30395221 )
2019
4
Spondyloarthritis-Related Autoimmune Aortitis Complicated by Severe Aortic Regurgitation. ( 30632387 )
2019
5
IgG4-related dacryocystitis and aortitis: A new association. ( 30642193 )
2019
6
Imaging aortitis. ( 30680900 )
2019
7
Aortitis and pachymeningitis: an unusual combination in granulomatosis with polyangiitis (myeloperoxidase-associated vasculitis). ( 30696638 )
2019
8
Aortitis Masquerading as Intramural Hematoma of the Ascending Aorta. ( 30703366 )
2019
9
Outcomes among 196 patients with non-infectious proximal aortitis. ( 30730604 )
2019
10
Diffuse inflammatory aneurysmal aortitis secondary to Scedosporium apiospermum complex in an immunocompetent individual. ( 30819537 )
2019
11
Emphysematous Aortitis by Clostridium septicum: A Rare and Lethal Complication of Right Colon Cancer. ( 30852054 )
2019
12
Tubercular aortitis presenting as primary aortoenteric fistula: Report of an uncommon case. ( 30860191 )
2019
13
Granulocyte colony-stimulating factor-associated aortitis in the Japanese Adverse Drug Event Report database. ( 30875590 )
2019
14
Aortitis as a Harbinger of Occult Malignancy. ( 30937207 )
2019
15
G-CSF-induced aortitis: Two cases and review of the literature. ( 30959218 )
2019
16
Microbiomes of Inflammatory Thoracic Aortic Aneurysms Due to Giant Cell Arteritis and Clinically Isolated Aortitis Differ From Those of Non-Inflammatory Aneurysms. ( 30993253 )
2019
17
Connecting the dots: a story of unknown fever, acute coronary syndrome and pan-aortitis-an occult relapse of a large vessel vasculitis. ( 31061187 )
2019
18
Is Granulocyte colony-stimulating factor associated with development of aortitis? ( 31100683 )
2019
19
Conservative treatment of non-aneurysmal infectious aortitis: a case report and review of the literature. ( 29745308 )
2019
20
Aspergillus aortitis in an immunocompetent patient presenting with acute endophthalmitis. ( 30344969 )
2018
21
A case of Brucella aortitis associated with development of thoracic aortic aneurysm and aortobronchial fistula. ( 30513449 )
2018
22
Ascending Aortic Aneurysm Secondary to Isolated Noninfectious Ascending Aortitis. ( 30585999 )
2018
23
Eosinophilic aortitis with thoracic aortic aneurysm and rupture in a captive-born owl monkey. ( 30187922 )
2018
24
Aortitis as a Rare Cause of Aortic Aneurysm and Valve Regurgitation: Is Repair Precluded? ( 29662705 )
2018
25
Impact of Medical Therapy on Late Morbidity and Mortality After Aortic Aneurysm Repair for Aortitis. ( 29408240 )
2018
26
Idiopathic aortitis presenting as pyrexia of unknown origin and delirium. ( 30290748 )
2018
27
A Case of IgG4-Related Aortitis and Pericarditis: Diagnostic Challenges and Natural History. ( 30323165 )
2018
28
Drug-induced aortitis in a patient with ovarian cancer treated with bevacizumab combination therapy. ( 30342665 )
2018
29
Incidence of Aortitis in Surgical Specimens of the Ascending Aorta Clinical Implications at Follow-Up. ( 30414447 )
2018
30
A case of syphilitic aortitis. ( 30517985 )
2018
31
Antineutrophil Cytoplasmic Antibody Vasculitis Causing Skull Base Inflammation and Aortitis. ( 30532374 )
2018
32
Case of ruptured Staphylococcus aureus aortitis: presentation and management. ( 30567156 )
2018
33
A Rare Case of Takayasu Arteritis With Intracranial Involvement, Aortic Valvulitis, and Giant Cell Aortitis. ( 30601198 )
2018
34
Aortitis caused by Abiotrophiadefectiva: Description of two cases. ( 30662691 )
2018
35
Infectious Aortitis: Could Early Radiology Improve Patient Outcome? ( 30755989 )
2018
36
IgG4-Related Aortitis. ( 30756063 )
2018
37
Back Pain: An Ominous Harbinger of Aortitis. ( 30788200 )
2018
38
Never forget the aorta: a case report of IgG4-related disease causing aortitis. ( 31020187 )
2018
39
Syphilitic aortitis and its complications in the modern era. ( 27982548 )
2018
40
Management of Salmonella typhimurium sepsis with thoracic infectious aortitis using 18F-FDG PET/CT. ( 28188443 )
2018
41
Pyogenic Aortitis - Role of 18F-FDG Positron Emission Tomography/Computed Tomography in Aortic Infection Imaging. ( 28747614 )
2018
42
Thoracic Aortitis Due to Salmonella enteritidis. ( 28754550 )
2018
43
Double-locus lymphoplasmacytic aortitis. ( 28893088 )
2018
44
Additional Diagnostic Value of Combined Angio-Computed Tomography and 18F-Fluorodeoxyglucose Positron Emission Tomography in Infectious Aortitis. ( 29055634 )
2018
45
Two-stage surgical approach for ruptured Salmonella aortitis. ( 29089095 )
2018
46
Infectious aortitis: A bridge too far. ( 29249489 )
2018
47
Immunoglobulin G Subclass 4-Related Lymphoplasmacytic Thoracic Aortitis in a Patient with Acute Type A Aortic Dissection. ( 29279461 )
2018
48
A Clinicopathological Analysis of Six Autopsy Cases of Sudden Unexpected Death due to Infectious Aortitis in Patients with Aortic Tears. ( 29321404 )
2018
49
Cardiac Sarcoidosis Concomitant with Large-vessel Aortitis Detected by 18F-fluorodeoxyglucose Positron Emission Tomography. ( 29321427 )
2018
50
Imaging giant cell arteritis and Aortitis in contrast enhanced 18F-FDG PET/CT: Which imaging score correlates best with laboratory inflammation markers? ( 29362158 )
2018

Variations for Aortitis

Expression for Aortitis

Search GEO for disease gene expression data for Aortitis.

Pathways for Aortitis

GO Terms for Aortitis

Molecular functions related to Aortitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 8.8 CDK9 MPO RERE

Sources for Aortitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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