MCID: ART012
MIFTS: 34

Aortitis

Categories: Cardiovascular diseases

Aliases & Classifications for Aortitis

Summaries for Aortitis

MalaCards based summary : Aortitis is related to vasculitis and spondyloarthropathy 1. An important gene associated with Aortitis is CRP (C-Reactive Protein). The drugs rituximab and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include heart, colon and thyroid.

Wikipedia : 77 Aortitis is the inflammation of the aortic wall. The disorder is potentially life-threatening and rare.... more...

Related Diseases for Aortitis

Diseases related to Aortitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 204)
# Related Disease Score Top Affiliating Genes
1 vasculitis 30.6 CRP MPO
2 spondyloarthropathy 1 30.3 CRP MRAP
3 temporal arteritis 30.0 CDK9 CRP SMUG1
4 polyarteritis nodosa 29.7 CRP MPO
5 appendicitis 29.7 CRP MPO
6 aortic valve disease 1 29.6 CRP MRAP
7 coronary artery anomaly 29.6 CRP SMUG1
8 pneumonia 29.3 CRP MPO
9 igg4-related aortitis 12.2
10 takayasu arteritis 11.6
11 aortic aneurysm 10.4
12 endocarditis 10.4
13 gastrointestinal tuberculosis 10.3 CRP SMUG1
14 cartilage disease 10.2 CRP SMUG1
15 tuberculous peritonitis 10.2 CRP SMUG1
16 pericardium disease 10.2 CRP SMUG1
17 discitis 10.2 CRP MRAP
18 xanthogranulomatous pyelonephritis 10.2 CRP SMUG1
19 pyuria 10.2 CRP MRAP
20 tenosynovitis 10.2 CRP MRAP
21 lemierre's syndrome 10.2 CRP SMUG1
22 bursitis 10.2 CRP MRAP
23 tendinitis 10.2 CRP MRAP
24 endocardium disease 10.2 CRP SMUG1
25 intermittent explosive disorder 10.2 CRP SMUG1
26 spondylitis 10.2
27 mesenteric lymphadenitis 10.2 CRP MRAP
28 renal tuberculosis 10.2 CRP MRAP
29 mononeuritis multiplex 10.2 CRP MPO
30 arthritis 10.2
31 rapidly progressive glomerulonephritis 10.2 CRP MPO
32 peritonitis 10.2 CRP MPO
33 relapsing polychondritis 10.2
34 pleural disease 10.2 CRP SMUG1
35 hypersensitivity vasculitis 10.2 CRP MPO
36 laryngeal tuberculosis 10.2 CDK9 SMUG1
37 hypersensitivity reaction type iii disease 10.2 CRP MPO
38 lymphatic system disease 10.2 CRP SMUG1
39 palindromic rheumatism 10.1 CRP MRAP
40 myocardial infarction 10.1
41 crohn's disease 10.1
42 aortic valve insufficiency 10.1
43 pulmonary hemosiderosis 10.1 CRP MPO
44 henoch-schoenlein purpura 10.1 CRP MPO
45 arteritic anterior ischemic optic neuropathy 10.1 CRP MPO
46 proctitis 10.1 CRP MPO
47 hypersensitivity reaction type iv disease 10.1 MRAP SMUG1
48 vulvitis 10.1 MPO MRAP
49 pericardium cancer 10.1 MPO SMUG1
50 suppurative cholangitis 10.1 CRP MPO

Graphical network of the top 20 diseases related to Aortitis:



Diseases related to Aortitis

Symptoms & Phenotypes for Aortitis

Drugs & Therapeutics for Aortitis

Drugs for Aortitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
2 Immunoglobulins Phase 1, Phase 2
3 Antineoplastic Agents, Immunological Phase 1, Phase 2
4 Immunoglobulin G Phase 1, Phase 2
5 Antibodies Phase 1, Phase 2
6 Immunologic Factors Phase 1, Phase 2
7 Antirheumatic Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Tocilizumab Dose-tapering and Interruption in Patients With Giant Cell Arteritis Achieving the Clinical Remission. Recruiting NCT03244709 Phase 4 Tocilizumab
2 Rituximab in IgG4-RD: A Phase 1-2 Trial Completed NCT01584388 Phase 1, Phase 2 Rituximab
3 Carotid Artery Neovascularization in Takayasu's and Giant Cell Arteritis Completed NCT01795456
4 VCRC Longitudinal Protocol for Aortitis Recruiting NCT03022331
5 Aortitis and Retroperitoneal Fibrosis: Evaluation of Diagnostic Criteria Recruiting NCT03133949
6 VCRC Tissue Repository Recruiting NCT02967068

Search NIH Clinical Center for Aortitis

Cochrane evidence based reviews: aortitis

Genetic Tests for Aortitis

Anatomical Context for Aortitis

MalaCards organs/tissues related to Aortitis:

42
Heart, Colon, Thyroid, Liver, Kidney, Bone, Bone Marrow

Publications for Aortitis

Articles related to Aortitis:

(show top 50) (show all 943)
# Title Authors Year
1
Spondyloarthritis-Related Autoimmune Aortitis Complicated by Severe Aortic Regurgitation. ( 30632387 )
2019
2
IgG4-related dacryocystitis and aortitis: A new association. ( 30642193 )
2019
3
Imaging aortitis. ( 30680900 )
2019
4
Aortitis and pachymeningitis: an unusual combination in granulomatosis with polyangiitis (myeloperoxidase-associated vasculitis). ( 30696638 )
2019
5
Aortitis masquerading as intramural hematoma of the ascending aorta. ( 30703366 )
2019
6
Outcomes among 196 patients with non-infectious proximal aortitis. ( 30730604 )
2019
7
Diffuse inflammatory aneurysmal aortitis secondary to Scedosporium apiospermum complex in an immunocompetent individual. ( 30819537 )
2019
8
Emphysematous Aortitis by Clostridium septicum: A Rare and Lethal Complication of Right Colon Cancer. ( 30852054 )
2019
9
Tubercular aortitis presenting as primary aortoenteric fistula: Report of an uncommon case. ( 30860191 )
2019
10
Granulocyte colony-stimulating factor-associated aortitis in the Japanese Adverse Drug Event Report database. ( 30875590 )
2019
11
Noninfectious aortitis: Experience with tocilizumab in a regional hospital. ( 29398465 )
2018
12
Additional Diagnostic Value of Combined Angio-Computed Tomography and<sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography in Infectious Aortitis. ( 29055634 )
2018
13
A Clinicopathological Analysis of Six Autopsy Cases of Sudden Unexpected Death Due to Infectious Aortitis in Patients with Aortic Tears. ( 29321404 )
2018
14
Infectious Aortitis: A Life-Threatening Endovascular Complication of Nontyphoidal <i>Salmonella</i> Bacteremia. ( 29808097 )
2018
15
Aortitis as a Rare Cause of Aortic Aneurysm and Valve Regurgitation: Is Repair Precluded? ( 29662705 )
2018
16
Subclinical aortitis after starting nivolumab in a patient with metastatic melanoma. A case of drug-associated aortitis? ( 29799390 )
2018
17
Impact of Medical Therapy on Late Morbidity and Mortality After Aortic Aneurysm Repair for Aortitis. ( 29408240 )
2018
18
Recurrent ventricular arrhythmia in a patient with aortitis and myocardial inflammation due to possible immunoglobulin G4-related disease. ( 29722185 )
2018
19
Conservative treatment of non-aneurysmal infectious aortitis: a case report and review of the literature. ( 29745308 )
2018
20
Infectious aortitis: A bridge too far. ( 29249489 )
2018
21
Imaging giant cell arteritis and Aortitis in contrast enhanced 18F-FDG PET/CT: Which imaging score correlates best with laboratory inflammation markers? ( 29362158 )
2018
22
Response to Jolobe: 'Beyond identification of GCA-related thoracic aortitis'. ( 29860324 )
2018
23
Surgical strategy for refractory aortitis. ( 29404904 )
2018
24
Myelodysplastic syndrome presenting as a BehAset's-like disease with aortitis. ( 29545422 )
2018
25
Two-stage surgical approach for ruptured Salmonella aortitis. ( 29089095 )
2018
26
A case of giant cell arteritis associated with a culture proven Coxiella burnetii aortitis. ( 29408476 )
2018
27
Beyond identification of GCA-related thoracic aortitis. ( 29860448 )
2018
28
Aortitis With an Aneurysm at Initial Presentation of Crohn Disease. ( 29927874 )
2018
29
Tuberculous Aortitis Associated With Pleuritis and Spondylitis. ( 29398471 )
2018
30
Acute infectious aortitis presenting as pyelonephritis. ( 29903668 )
2018
31
A rare case of <i>Clostridium septicum</i> aortitis with colon adenocarcinoma. ( 29707691 )
2018
32
Cardiac Sarcoidosis Concomitant with Large-vessel Aortitis Detected by<sup>18</sup>F-fluorodeoxyglucose Positron Emission Tomography. ( 29321427 )
2018
33
Aspergillus aortitis in an immunocompetent patient presenting with acute endophthalmitis. ( 30344969 )
2018
34
A case of Brucella aortitis associated with development of thoracic aortic aneurysm and aortobronchial fistula. ( 30513449 )
2018
35
Ascending Aortic Aneurysm Secondary to Isolated Noninfectious Ascending Aortitis. ( 30585999 )
2018
36
Eosinophilic aortitis with thoracic aortic aneurysm and rupture in a captive-born owl monkey. ( 30187922 )
2018
37
Granulocyte colony-stimulating factors and aortitis: A rare adverse event. ( 30016548 )
2018
38
Aortitis. ( 30077362 )
2018
39
Clostridium septicum arthroplasty infection: beware of occult aortitis and malignancy. ( 30153761 )
2018
40
Aortitis Presenting as Fever of Unknown Origin. ( 30158332 )
2018
41
Idiopathic aortitis presenting as pyrexia of unknown origin and delirium. ( 30290748 )
2018
42
A Case of IgG4-Related Aortitis and Pericarditis: Diagnostic Challenges and Natural History. ( 30323165 )
2018
43
Drug-induced aortitis in a patient with ovarian cancer treated with bevacizumab combination therapy. ( 30342665 )
2018
44
A Case of IBD Immunosuppression Related Salmonella Aortitis Requiring Emergency Vascular Grafting. ( 30395221 )
2018
45
Incidence of Aortitis in Surgical Specimens of the Ascending Aorta Clinical Implications at Follow-Up. ( 30414447 )
2018
46
A case of syphilitic aortitis. ( 30517985 )
2018
47
Antineutrophil Cytoplasmic Antibody Vasculitis Causing Skull Base Inflammation and Aortitis. ( 30532374 )
2018
48
Case of ruptured Staphylococcus aureus aortitis: presentation and management. ( 30567156 )
2018
49
A Rare Case of Takayasu Arteritis With Intracranial Involvement, Aortic Valvulitis, and Giant Cell Aortitis. ( 30601198 )
2018
50
Aortitis caused by Abiotrophiadefectiva: Description of two cases. ( 30662691 )
2018

Variations for Aortitis

Expression for Aortitis

Search GEO for disease gene expression data for Aortitis.

Pathways for Aortitis

GO Terms for Aortitis

Molecular functions related to Aortitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 8.8 CDK9 MPO RERE

Sources for Aortitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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