Apc-Associated Polyposis Conditions disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: APC006 MIFTS: 12	Apc-Associated Polyposis Conditions
Genes Tissues Related diseases Publications Expand all tables

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Aliases & Classifications for Apc-Associated Polyposis Conditions

MalaCards integrated aliases for Apc-Associated Polyposis Conditions:

Name: Apc-Associated Polyposis Conditions ²⁴

Characteristics:

GeneReviews:

²⁴

Penetrance In fap, the penetrance of colonic adenomatous polyposis and colon cancer is virtually 100% in untreated individuals....

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Summaries for Apc-Associated Polyposis Conditions

MalaCards based summary : Apc-Associated Polyposis Conditions is related to colorectal cancer and familial adenomatous polyposis 1. An important gene associated with Apc-Associated Polyposis Conditions is APC (APC Regulator Of WNT Signaling Pathway). Affiliated tissues include colon, thyroid and testes.

GeneReviews: NBK1345

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Related Diseases for Apc-Associated Polyposis Conditions

Diseases related to Apc-Associated Polyposis Conditions via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score
1	colorectal cancer	10.1
2	familial adenomatous polyposis 1	10.1
3	polyposis of gastric fundus without polyposis coli	10.1
4	familial adenomatous polyposis	10.1
5	gastric adenocarcinoma	10.1
6	adenoma	10.1
7	hepatoblastoma	10.1
8	attenuated familial adenomatous polyposis	10.1
9	gastric adenocarcinoma and proximal polyposis of the stomach	10.1
10	thyroid carcinoma	10.1

Graphical network of the top 20 diseases related to Apc-Associated Polyposis Conditions:

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Symptoms & Phenotypes for Apc-Associated Polyposis Conditions

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Drugs & Therapeutics for Apc-Associated Polyposis Conditions

Search Clinical Trials , NIH Clinical Center for Apc-Associated Polyposis Conditions

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Genetic Tests for Apc-Associated Polyposis Conditions

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Anatomical Context for Apc-Associated Polyposis Conditions

MalaCards organs/tissues related to Apc-Associated Polyposis Conditions:

⁴⁰

Colon, Thyroid, Testes, Skin

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Publications for Apc-Associated Polyposis Conditions

Articles related to Apc-Associated Polyposis Conditions:

(show top 50) (show all 173)

#	Title	Authors	PMID	Year
1	The first European family with gastric adenocarcinoma and proximal polyposis of the stomach: case report and review of the literature. ²⁴	Repak R...Bures J	27343414	2016
2	Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology. ²⁴	Provenzale D...Darlow S	27496117	2016
3	Exome Sequencing Identifies Biallelic MSH3 Germline Mutations as a Recessive Subtype of Colorectal Adenomatous Polyposis. ²⁴	Adam R...Aretz S	27476653	2016
4	Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant. ²⁴	Li J...Chenevix-Trench G	27087319	2016
5	Effect of Sulindac and Erlotinib vs Placebo on Duodenal Neoplasia in Familial Adenomatous Polyposis: A Randomized Clinical Trial. ²⁴	Samadder NJ...Kuwada SK	27002448	2016
6	The Contribution of Whole Gene Deletions and Large Rearrangements to the Mutation Spectrum in Inherited Tumor Predisposing Syndromes. ²⁴	Smith MJ...Evans DG	26615784	2016
7	Low-level APC mutational mosaicism is the underlying cause in a substantial fraction of unexplained colorectal adenomatous polyposis cases. ²⁴	Spier I...Aretz S	26613750	2016
8	An international randomised trial of celecoxib versus celecoxib plus difluoromethylornithine in patients with familial adenomatous polyposis. ²⁴	Lynch PM...Hawk E	25792707	2016
9	Biallelic NTHL1 Mutations in a Woman with Multiple Primary Tumors. ²⁴	Rivera B...Foulkes WD	26559593	2015
10	Cribriform-morular variant of papillary thyroid carcinoma. ²⁴	Pradhan D...Mohanty SK	26293799	2015
11	A germline homozygous mutation in the base-excision repair gene NTHL1 causes adenomatous polyposis and colorectal cancer. ²⁴	Weren RD...Hoogerbrugge N	25938944	2015
12	Hereditary colorectal cancer syndromes: American Society of Clinical Oncology clinical practice guideline endorsement of the familial risk-colorectal cancer: European Society for Medical Oncology clinical practice guidelines. ²⁴	Stoffel EM...European Society for Medical Oncology	25829526	2015
13	Desmoids and genotype in familial adenomatous polyposis. ²⁴	Church J...Kalady M	25751801	2015
14	APC rearrangements in familial adenomatous polyposis: heterogeneity of deletion lengths and breakpoint sequences underlies similar phenotypes. ²⁴	Quadri M...Ranzani GN	25159889	2015
15	ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes. ²⁴	Syngal S...American College of Gastroenterology	25645574	2015
16	FAP Associated Papillary Thyroid Carcinoma: A Peculiar Subtype of Familial Nonmedullary Thyroid Cancer. ²⁴	Cetta F	26697262	2015
17	Therapy-associated polyposis as a late sequela of cancer treatment. ²⁴	Yurgelun MB...Syngal S	24362051	2014
18	Wnt signaling in adult intestinal stem cells and cancer. ²⁴	Krausova M...Korinek V	24308963	2014
19	Preventive effects of low-dose aspirin on colorectal adenoma growth in patients with familial adenomatous polyposis: double-blind, randomized clinical trial. ²⁴	Ishikawa H...Sakai T	24133627	2013
20	The prevalence of thyroid cancer and benign thyroid disease in patients with familial adenomatous polyposis may be higher than previously recognized. ²⁴	Steinhagen E...Markowitz AJ	22425061	2012
21	Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): a new autosomal dominant syndrome. ²⁴	Worthley DL...Suthers GK	21813476	2012
22	Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1. ²⁴	Jaeger E...Tomlinson I	22561515	2012
23	Inactivation of promoter 1B of APC causes partial gene silencing: evidence for a significant role of the promoter in regulation and causative of familial adenomatous polyposis. ²⁴	Rohlin A...Nordling M	21643010	2011
24	Risk factors predicting desmoid occurrence in patients with familial adenomatous polyposis: a meta-analysis. ²⁴	Sinha A...Clark SK	20528895	2011
25	Constitutional mismatch repair-deficiency syndrome presenting as colonic adenomatous polyposis: clues from the skin. ²⁴	Jasperson KW...Burt RW	21039432	2011
26	A nation-wide study comparing sporadic and familial adenomatous polyposis-related desmoid-type fibromatoses. ²⁴	Nieuwenhuis MH...Vasen HF	20830713	2011
27	A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis. ²⁴	Burn J...International CAPP consortium	21543343	2011
28	Screening for thyroid cancer in patients with familial adenomatous polyposis. ²⁴	Jarrar AM...Church JM	21173694	2011
29	Defining phenotypes and cancer risk in hyperplastic polyposis syndrome. ²⁴	Kalady MF...Church JM	21228663	2011
30	Prevalence of skin lesions in familial adenomatous polyposis: a marker for presymptomatic diagnosis? ²⁴	Burger B...Heinimann K	22135120	2011
31	Population prevalence of familial cancer and common hereditary cancer syndromes. The 2005 California Health Interview Survey. ²⁴	Scheuner MT...Freedman AN	20921897	2010
32	Female fertility after colorectal surgery for familial adenomatous polyposis: a nationwide cross-sectional study. ²⁴	Nieuwenhuis MH...Vasen HF	20622653	2010
33	Jejunal cancer in patients with familial adenomatous polyposis. ²⁴	Ruys AT...Mathus-Vliegen EM	20399906	2010
34	Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis. ²⁴	West NJ...Hull MA	20348368	2010
35	Adrenocortical Secreting Mass in a Patient with Gardner's Syndrome: A Case Report. ²⁴	Rekik NM...Abid M	21209732	2010
36	Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial. ²⁴	Meyskens FL...Gerner EW	18841250	2008
37	Fundic gland polyp dysplasia is common in familial adenomatous polyposis. ²⁴	Bianchi LK...Church JM	18237868	2008
38	Gastric adenocarcinoma arising from fundic gland polyps in a patient with familial adenomatous polyposis syndrome. ²⁴	Garrean S...Espat NJ	18274437	2008
39	Gonadal mosaicism and familial adenomatous polyposis. ²⁴	Schwab AL...Burt RW	18026870	2008
40	American founder mutation for attenuated familial adenomatous polyposis. ²⁴	Neklason DW...Burt RW	18063416	2008
41	Somatic APC mosaicism: an underestimated cause of polyposis coli. ²⁴	Hes FJ...Tops CM	17604324	2008
42	Familial adenomatous polyposis in a patient with unexplained mental retardation. ²⁴	Heald B...Eng C	18046442	2007
43	Genotype-phenotype correlations in 19 Dutch cases with APC gene deletions and a literature review. ²⁴	Nielsen M...Weiss MM	17568392	2007
44	Somatic APC mosaicism: a frequent cause of familial adenomatous polyposis (FAP). ²⁴	Aretz S...Friedl W	17486639	2007
45	Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP. ²⁴	Suraweera N...Silver A	17496195	2007
46	Constitutive deficiency in DNA mismatch repair: is it time for Lynch III? ²⁴	Felton KE...Andrew SE	17539898	2007
47	Germline mutations in APC and MUTYH are responsible for the majority of families with attenuated familial adenomatous polyposis. ²⁴	Nielsen M...Vasen HF	17489848	2007
48	Prevalence of thyroid cancer in familial adenomatous polyposis syndrome and the role of screening ultrasound examinations. ²⁴	Herraiz M...Chung DC	17258512	2007
49	Correlations between mutation site in APC and phenotype of familial adenomatous polyposis (FAP): a review of the literature. ²⁴	Nieuwenhuis MH...Vasen HF	17064931	2007
50	Strategies and outcomes of PGD of familial adenomatous polyposis. ²⁴	Moutou C...Viville S	17114207	2007

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Genes for Apc-Associated Polyposis Conditions

Genes related to Apc-Associated Polyposis Conditions (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	APC	APC Regulator Of WNT Signaling Pathway	Protein Coding	7.05	GeneCards inferred via : Publications (show sections)

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Variations for Apc-Associated Polyposis Conditions

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Expression for Apc-Associated Polyposis Conditions

Search GEO for disease gene expression data for Apc-Associated Polyposis Conditions.

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Pathways for Apc-Associated Polyposis Conditions

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GO Terms for Apc-Associated Polyposis Conditions

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