MCID: APC006
MIFTS: 12

Apc-Associated Polyposis Conditions

Aliases & Classifications for Apc-Associated Polyposis Conditions

MalaCards integrated aliases for Apc-Associated Polyposis Conditions:

Name: Apc-Associated Polyposis Conditions 24

Characteristics:

GeneReviews:

24
Penetrance In fap, the penetrance of colonic adenomatous polyposis and colon cancer is virtually 100% in untreated individuals....

Summaries for Apc-Associated Polyposis Conditions

MalaCards based summary : Apc-Associated Polyposis Conditions is related to colorectal cancer and familial adenomatous polyposis 1. An important gene associated with Apc-Associated Polyposis Conditions is APC (APC Regulator Of WNT Signaling Pathway). Affiliated tissues include colon, thyroid and testes.

GeneReviews: NBK1345

Related Diseases for Apc-Associated Polyposis Conditions

Diseases related to Apc-Associated Polyposis Conditions via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 colorectal cancer 10.1
2 familial adenomatous polyposis 1 10.1
3 polyposis of gastric fundus without polyposis coli 10.1
4 familial adenomatous polyposis 10.1
5 gastric adenocarcinoma 10.1
6 adenoma 10.1
7 hepatoblastoma 10.1
8 attenuated familial adenomatous polyposis 10.1
9 gastric adenocarcinoma and proximal polyposis of the stomach 10.1
10 thyroid carcinoma 10.1

Graphical network of the top 20 diseases related to Apc-Associated Polyposis Conditions:



Diseases related to Apc-Associated Polyposis Conditions

Symptoms & Phenotypes for Apc-Associated Polyposis Conditions

Drugs & Therapeutics for Apc-Associated Polyposis Conditions

Search Clinical Trials , NIH Clinical Center for Apc-Associated Polyposis Conditions

Genetic Tests for Apc-Associated Polyposis Conditions

Anatomical Context for Apc-Associated Polyposis Conditions

MalaCards organs/tissues related to Apc-Associated Polyposis Conditions:

41
Colon, Thyroid, Testes, Skin

Publications for Apc-Associated Polyposis Conditions

Articles related to Apc-Associated Polyposis Conditions:

(show top 50) (show all 173)
# Title Authors PMID Year
1
The first European family with gastric adenocarcinoma and proximal polyposis of the stomach: case report and review of the literature. 4
27343414 2016
2
Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology. 4
27496117 2016
3
Exome Sequencing Identifies Biallelic MSH3 Germline Mutations as a Recessive Subtype of Colorectal Adenomatous Polyposis. 4
27476653 2016
4
Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant. 4
27087319 2016
5
Effect of Sulindac and Erlotinib vs Placebo on Duodenal Neoplasia in Familial Adenomatous Polyposis: A Randomized Clinical Trial. 4
27002448 2016
6
The Contribution of Whole Gene Deletions and Large Rearrangements to the Mutation Spectrum in Inherited Tumor Predisposing Syndromes. 4
26615784 2016
7
Low-level APC mutational mosaicism is the underlying cause in a substantial fraction of unexplained colorectal adenomatous polyposis cases. 4
26613750 2016
8
An international randomised trial of celecoxib versus celecoxib plus difluoromethylornithine in patients with familial adenomatous polyposis. 4
25792707 2016
9
Biallelic NTHL1 Mutations in a Woman with Multiple Primary Tumors. 4
26559593 2015
10
Cribriform-morular variant of papillary thyroid carcinoma. 4
26293799 2015
11
A germline homozygous mutation in the base-excision repair gene NTHL1 causes adenomatous polyposis and colorectal cancer. 4
25938944 2015
12
Hereditary colorectal cancer syndromes: American Society of Clinical Oncology clinical practice guideline endorsement of the familial risk-colorectal cancer: European Society for Medical Oncology clinical practice guidelines. 4
25829526 2015
13
Desmoids and genotype in familial adenomatous polyposis. 4
25751801 2015
14
APC rearrangements in familial adenomatous polyposis: heterogeneity of deletion lengths and breakpoint sequences underlies similar phenotypes. 4
25159889 2015
15
ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes. 4
25645574 2015
16
FAP Associated Papillary Thyroid Carcinoma: A Peculiar Subtype of Familial Nonmedullary Thyroid Cancer. 4
26697262 2015
17
Therapy-associated polyposis as a late sequela of cancer treatment. 4
24362051 2014
18
Wnt signaling in adult intestinal stem cells and cancer. 4
24308963 2014
19
Preventive effects of low-dose aspirin on colorectal adenoma growth in patients with familial adenomatous polyposis: double-blind, randomized clinical trial. 4
24133627 2013
20
The prevalence of thyroid cancer and benign thyroid disease in patients with familial adenomatous polyposis may be higher than previously recognized. 4
22425061 2012
21
Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1. 4
22561515 2012
22
Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): a new autosomal dominant syndrome. 4
21813476 2012
23
Inactivation of promoter 1B of APC causes partial gene silencing: evidence for a significant role of the promoter in regulation and causative of familial adenomatous polyposis. 4
21643010 2011
24
Risk factors predicting desmoid occurrence in patients with familial adenomatous polyposis: a meta-analysis. 4
20528895 2011
25
Constitutional mismatch repair-deficiency syndrome presenting as colonic adenomatous polyposis: clues from the skin. 4
21039432 2011
26
A nation-wide study comparing sporadic and familial adenomatous polyposis-related desmoid-type fibromatoses. 4
20830713 2011
27
A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis. 4
21543343 2011
28
Screening for thyroid cancer in patients with familial adenomatous polyposis. 4
21173694 2011
29
Defining phenotypes and cancer risk in hyperplastic polyposis syndrome. 4
21228663 2011
30
Prevalence of skin lesions in familial adenomatous polyposis: a marker for presymptomatic diagnosis? 4
22135120 2011
31
Population prevalence of familial cancer and common hereditary cancer syndromes. The 2005 California Health Interview Survey. 4
20921897 2010
32
Jejunal cancer in patients with familial adenomatous polyposis. 4
20399906 2010
33
Female fertility after colorectal surgery for familial adenomatous polyposis: a nationwide cross-sectional study. 4
20622653 2010
34
Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis. 4
20348368 2010
35
Adrenocortical Secreting Mass in a Patient with Gardner's Syndrome: A Case Report. 4
21209732 2010
36
Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial. 4
18841250 2008
37
Fundic gland polyp dysplasia is common in familial adenomatous polyposis. 4
18237868 2008
38
Gastric adenocarcinoma arising from fundic gland polyps in a patient with familial adenomatous polyposis syndrome. 4
18274437 2008
39
Gonadal mosaicism and familial adenomatous polyposis. 4
18026870 2008
40
Somatic APC mosaicism: an underestimated cause of polyposis coli. 4
17604324 2008
41
American founder mutation for attenuated familial adenomatous polyposis. 4
18063416 2008
42
Familial adenomatous polyposis in a patient with unexplained mental retardation. 4
18046442 2007
43
Somatic APC mosaicism: a frequent cause of familial adenomatous polyposis (FAP). 4
17486639 2007
44
Genotype-phenotype correlations in 19 Dutch cases with APC gene deletions and a literature review. 4
17568392 2007
45
Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP. 4
17496195 2007
46
Constitutive deficiency in DNA mismatch repair: is it time for Lynch III? 4
17539898 2007
47
Germline mutations in APC and MUTYH are responsible for the majority of families with attenuated familial adenomatous polyposis. 4
17489848 2007
48
Prevalence of thyroid cancer in familial adenomatous polyposis syndrome and the role of screening ultrasound examinations. 4
17258512 2007
49
Strategies and outcomes of PGD of familial adenomatous polyposis. 4
17114207 2007
50
Correlations between mutation site in APC and phenotype of familial adenomatous polyposis (FAP): a review of the literature. 4
17064931 2007

Variations for Apc-Associated Polyposis Conditions

Expression for Apc-Associated Polyposis Conditions

Search GEO for disease gene expression data for Apc-Associated Polyposis Conditions.

Pathways for Apc-Associated Polyposis Conditions

GO Terms for Apc-Associated Polyposis Conditions

Sources for Apc-Associated Polyposis Conditions

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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