MCID: APC006
MIFTS: 12

Apc-Associated Polyposis Conditions

Aliases & Classifications for Apc-Associated Polyposis Conditions

MalaCards integrated aliases for Apc-Associated Polyposis Conditions:

Name: Apc-Associated Polyposis Conditions 24

Characteristics:

GeneReviews:

24
Penetrance In fap, the penetrance of colonic adenomatous polyposis and colon cancer is virtually 100% in untreated individuals....

Summaries for Apc-Associated Polyposis Conditions

MalaCards based summary : Apc-Associated Polyposis Conditions is related to colorectal cancer and familial adenomatous polyposis 1. An important gene associated with Apc-Associated Polyposis Conditions is APC (APC Regulator Of WNT Signaling Pathway). Affiliated tissues include colon, thyroid and testes.

GeneReviews: NBK1345

Related Diseases for Apc-Associated Polyposis Conditions

Diseases related to Apc-Associated Polyposis Conditions via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 9, show less)
# Related Disease Score Top Affiliating Genes
1 colorectal cancer 10.1
2 familial adenomatous polyposis 1 10.1
3 polyposis of gastric fundus without polyposis coli 10.1
4 familial adenomatous polyposis 10.1
5 gastric adenocarcinoma 10.1
6 adenoma 10.1
7 hepatoblastoma 10.1
8 gastric adenocarcinoma and proximal polyposis of the stomach 10.1
9 thyroid carcinoma 10.1

Graphical network of the top 20 diseases related to Apc-Associated Polyposis Conditions:



Diseases related to Apc-Associated Polyposis Conditions

Symptoms & Phenotypes for Apc-Associated Polyposis Conditions

Drugs & Therapeutics for Apc-Associated Polyposis Conditions

Search Clinical Trials , NIH Clinical Center for Apc-Associated Polyposis Conditions

Genetic Tests for Apc-Associated Polyposis Conditions

Anatomical Context for Apc-Associated Polyposis Conditions

MalaCards organs/tissues related to Apc-Associated Polyposis Conditions:

40
Colon, Thyroid, Testes, Skin

Publications for Apc-Associated Polyposis Conditions

Articles related to Apc-Associated Polyposis Conditions:

(showing 173, show less)
# Title Authors PMID Year
1
The first European family with gastric adenocarcinoma and proximal polyposis of the stomach: case report and review of the literature. 24
27343414 2016
2
Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology. 24
27496117 2016
3
Exome Sequencing Identifies Biallelic MSH3 Germline Mutations as a Recessive Subtype of Colorectal Adenomatous Polyposis. 24
27476653 2016
4
Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant. 24
27087319 2016
5
Effect of Sulindac and Erlotinib vs Placebo on Duodenal Neoplasia in Familial Adenomatous Polyposis: A Randomized Clinical Trial. 24
27002448 2016
6
Low-level APC mutational mosaicism is the underlying cause in a substantial fraction of unexplained colorectal adenomatous polyposis cases. 24
26613750 2016
7
The Contribution of Whole Gene Deletions and Large Rearrangements to the Mutation Spectrum in Inherited Tumor Predisposing Syndromes. 24
26615784 2016
8
An international randomised trial of celecoxib versus celecoxib plus difluoromethylornithine in patients with familial adenomatous polyposis. 24
25792707 2016
9
Biallelic NTHL1 Mutations in a Woman with Multiple Primary Tumors. 24
26559593 2015
10
Cribriform-morular variant of papillary thyroid carcinoma. 24
26293799 2015
11
A germline homozygous mutation in the base-excision repair gene NTHL1 causes adenomatous polyposis and colorectal cancer. 24
25938944 2015
12
Hereditary colorectal cancer syndromes: American Society of Clinical Oncology clinical practice guideline endorsement of the familial risk-colorectal cancer: European Society for Medical Oncology clinical practice guidelines. 24
25829526 2015
13
Desmoids and genotype in familial adenomatous polyposis. 24
25751801 2015
14
APC rearrangements in familial adenomatous polyposis: heterogeneity of deletion lengths and breakpoint sequences underlies similar phenotypes. 24
25159889 2015
15
ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes. 24
25645574 2015
16
FAP Associated Papillary Thyroid Carcinoma: A Peculiar Subtype of Familial Nonmedullary Thyroid Cancer. 24
26697262 2015
17
Therapy-associated polyposis as a late sequela of cancer treatment. 24
24362051 2014
18
Wnt signaling in adult intestinal stem cells and cancer. 24
24308963 2014
19
Preventive effects of low-dose aspirin on colorectal adenoma growth in patients with familial adenomatous polyposis: double-blind, randomized clinical trial. 24
24133627 2013
20
The prevalence of thyroid cancer and benign thyroid disease in patients with familial adenomatous polyposis may be higher than previously recognized. 24
22425061 2012
21
Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): a new autosomal dominant syndrome. 24
21813476 2012
22
Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1. 24
22561515 2012
23
Inactivation of promoter 1B of APC causes partial gene silencing: evidence for a significant role of the promoter in regulation and causative of familial adenomatous polyposis. 24
21643010 2011
24
Risk factors predicting desmoid occurrence in patients with familial adenomatous polyposis: a meta-analysis. 24
20528895 2011
25
Constitutional mismatch repair-deficiency syndrome presenting as colonic adenomatous polyposis: clues from the skin. 24
21039432 2011
26
A nation-wide study comparing sporadic and familial adenomatous polyposis-related desmoid-type fibromatoses. 24
20830713 2011
27
A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis. 24
21543343 2011
28
Screening for thyroid cancer in patients with familial adenomatous polyposis. 24
21173694 2011
29
Defining phenotypes and cancer risk in hyperplastic polyposis syndrome. 24
21228663 2011
30
Prevalence of skin lesions in familial adenomatous polyposis: a marker for presymptomatic diagnosis? 24
22135120 2011
31
Population prevalence of familial cancer and common hereditary cancer syndromes. The 2005 California Health Interview Survey. 24
20921897 2010
32
Jejunal cancer in patients with familial adenomatous polyposis. 24
20399906 2010
33
Female fertility after colorectal surgery for familial adenomatous polyposis: a nationwide cross-sectional study. 24
20622653 2010
34
Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis. 24
20348368 2010
35
Adrenocortical Secreting Mass in a Patient with Gardner's Syndrome: A Case Report. 24
21209732 2010
36
Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial. 24
18841250 2008
37
Fundic gland polyp dysplasia is common in familial adenomatous polyposis. 24
18237868 2008
38
Gastric adenocarcinoma arising from fundic gland polyps in a patient with familial adenomatous polyposis syndrome. 24
18274437 2008
39
Somatic APC mosaicism: an underestimated cause of polyposis coli. 24
17604324 2008
40
Gonadal mosaicism and familial adenomatous polyposis. 24
18026870 2008
41
American founder mutation for attenuated familial adenomatous polyposis. 24
18063416 2008
42
Familial adenomatous polyposis in a patient with unexplained mental retardation. 24
18046442 2007
43
Genotype-phenotype correlations in 19 Dutch cases with APC gene deletions and a literature review. 24
17568392 2007
44
Somatic APC mosaicism: a frequent cause of familial adenomatous polyposis (FAP). 24
17486639 2007
45
Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP. 24
17496195 2007
46
Constitutive deficiency in DNA mismatch repair: is it time for Lynch III? 24
17539898 2007
47
Germline mutations in APC and MUTYH are responsible for the majority of families with attenuated familial adenomatous polyposis. 24
17489848 2007
48
Prevalence of thyroid cancer in familial adenomatous polyposis syndrome and the role of screening ultrasound examinations. 24
17258512 2007
49
Strategies and outcomes of PGD of familial adenomatous polyposis. 24
17114207 2007
50
Correlations between mutation site in APC and phenotype of familial adenomatous polyposis (FAP): a review of the literature. 24
17064931 2007
51
Implication of MYH in colorectal polyposis. 24
17122612 2006
52
Preimplantation genetic diagnosis of familial adenomatous polyposis. 24
17169185 2006
53
An evidence-based, multidisciplinary approach to the clinical considerations, management, and surveillance of adrenal lesions in familial adenomatous polyposis: report of three cases. 24
17041748 2006
54
ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes. 24
17008706 2006
55
Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation. 24
16461775 2006
56
Tumour surveillance in Beckwith-Wiedemann syndrome and hemihyperplasia: a critical review of the evidence and suggested guidelines for local practice. 24
16925531 2006
57
Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. 24
16757216 2006
58
MUTYH-associated polyposis: 70 of 71 patients with biallelic mutations present with an attenuated or atypical phenotype. 24
16557584 2006
59
Congenital hypertrophy of the retinal pigment epithelium (CHRPE) in familial colorectal cancer. 24
16944273 2006
60
Successful chemotherapeutic modality of doxorubicin plus dacarbazine for the treatment of desmoid tumors in association with familial adenomatous polyposis. 24
16382119 2006
61
Familial adenomatous polyposis: experience from a study of 1164 unrelated german polyposis patients. 24
20223039 2005
62
Phenotype associated with recessively inherited mutations in DNA mismatch repair (MMR) genes. 24
16042583 2005
63
Oral contraceptives and polyp regression in familial adenomatous polyposis. 24
15825088 2005
64
Prevalence and morphology of pouch and ileal adenomas in familial adenomatous polyposis. 24
15747076 2005
65
Large deletions of the APC gene in 15% of mutation-negative patients with classical polyposis (FAP): a Belgian study. 24
15643602 2005
66
Large submicroscopic genomic APC deletions are a common cause of typical familial adenomatous polyposis. 24
15689459 2005
67
A comparison of the phenotype and genotype in adenomatous polyposis patients with and without a family history. 24
15951963 2005
68
Dosage analysis of cancer predisposition genes by multiplex ligation-dependent probe amplification. 24
15475941 2004
69
Genetic testing and phenotype in a large kindred with attenuated familial adenomatous polyposis. 24
15300576 2004
70
A clinical overview of familial adenomatous polyposis derived from the database of the Polyposis Registry of Japan. 24
15375708 2004
71
MYH mutations in patients with attenuated and classic polyposis and with young-onset colorectal cancer without polyps. 24
15236166 2004
72
Gastric fundic gland polyps. 24
14598262 2003
73
Anal transitional zone cancer after restorative proctocolectomy and ileoanal anastomosis in familial adenomatous polyposis: report of two cases. 24
14530685 2003
74
A prospective study of the clinical, genetic, screening, and pathologic features of a family with hereditary mixed polyposis syndrome. 24
14572586 2003
75
Risk of rectal cancer in patients after colectomy and ileorectal anastomosis for familial adenomatous polyposis: a function of available surgical options. 24
12972960 2003
76
Practice parameters for the treatment of patients with dominantly inherited colorectal cancer (familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer). 24
12907889 2003
77
Treatment of desmoids and mesenteric fibromatosis in familial adenomatous polyposis with raloxifene. 24
14606641 2003
78
Multiple approach to the exploration of genotype-phenotype correlations in familial adenomatous polyposis. 24
12721244 2003
79
Stepwise progression of familial adenomatous polyposis-associated desmoid precursor lesions demonstrated by a novel CT scoring system. 24
12682541 2003
80
Female fecundity before and after operation for familial adenomatous polyposis. 24
12555301 2003
81
Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. 24
12610628 2003
82
Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH. 24
12606733 2003
83
Genetic testing for hereditary colorectal cancer in children: long-term psychological effects. 24
12494429 2003
84
Genotype and phenotype of patients with both familial adenomatous polyposis and thyroid carcinoma. 24
14574158 2003
85
Attenuated familial adenomatous polyposis (AFAP). A review of the literature. 24
14574166 2003
86
Preimplantation genetic diagnosis for cancer predisposition. 24
12419039 2002
87
Challenge in the differentiation between attenuated familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer: case report with review of the literature. 24
12135043 2002
88
A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis. 24
12010890 2002
89
Primary chemoprevention of familial adenomatous polyposis with sulindac. 24
11932472 2002
90
Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas. 24
11867715 2002
91
Gardner-associated fibromas (GAF) in young patients: a distinct fibrous lesion that identifies unsuspected Gardner syndrome and risk for fibromatosis. 24
11342777 2001
92
Duodenal adenomatosis in familial adenomatous polyposis coli. A review of the literature and results from the Heidelberg Polyposis Register. 24
11355321 2001
93
Can APC mutation analysis contribute to therapeutic decisions in familial adenomatous polyposis? Experience from 680 FAP families. 24
11247896 2001
94
A role for the Adenomatous Polyposis Coli protein in chromosome segregation. 24
11283619 2001
95
Mutations in the APC tumour suppressor gene cause chromosomal instability. 24
11283620 2001
96
Genotype and phenotype factors as determinants of desmoid tumors in patients with familial adenomatous polyposis. 24
11241320 2001
97
Fundic gland polyposis with high-grade dysplasia in a child with attenuated familial adenomatous polyposis and familial gastric cancer. 24
11321399 2001
98
Impact of screening examinations on survival in familial adenomatous polyposis. 24
11199368 2000
99
Adrenal masses are associated with familial adenomatous polyposis. 24
11156460 2000
100
The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis. 24
10982779 2000
101
The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. 24
10874062 2000
102
Biology of the adenomatous polyposis coli tumor suppressor. 24
10784639 2000
103
Surgical management of intra-abdominal desmoid tumours. 24
10792318 2000
104
Prior pregnancy ameliorates the course of intra-abdominal desmoid tumors in patients with familial adenomatous polyposis. 24
10789737 2000
105
A germline mutation at the extreme 3' end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor. 24
10782927 2000
106
UMD (Universal mutation database): a generic software to build and analyze locus-specific databases. 24
10612827 2000
107
Germline mutations of the APC gene in patients with familial adenomatous polyposis-associated thyroid carcinoma: results from a European cooperative study. 24
10634400 2000
108
Epidemiology of familial adenomatous polyposis in Sweden: changes over time and differences in phenotype between males and females. 24
10636071 1999
109
Notable intrafamilial phenotypic variability in a kindred with familial adenomatous polyposis and an APC mutation in exon 9. 24
10562580 1999
110
Attenuated familial adenomatous polyposis in a man with an interstitial deletion of chromosome arm 5q. 24
10494086 1999
111
Desmoid tumours complicating familial adenomatous polyposis. 24
10504375 1999
112
Management of duodenal adenomas in familial adenomatous polyposis. 24
10494690 1999
113
Gastric adenocarcinoma associated with fundic gland polyps in a patient with attenuated familial adenomatous polyposis. 24
10445562 1999
114
Upper gastrointestinal polyps in familial adenomatous polyposis. 24
10370594 1999
115
Molecular analysis of the APC gene in 205 families: extended genotype-phenotype correlations in FAP and evidence for the role of APC amino acid changes in colorectal cancer predisposition. 24
9950360 1999
116
Upper gastrointestinal disease in patients with familial adenomatous polyposis. 24
9667698 1998
117
Genotype-phenotype correlations in attenuated adenomatous polyposis coli. 24
9585611 1998
118
Cost analysis of alternative approaches to colorectal screening in familial adenomatous polyposis. 24
9558276 1998
119
Extracolonic manifestations of familial adenomatous polyposis: desmoid tumours, and upper gastrointestinal adenomas and carcinomas. 24
9515758 1998
120
Novel germline mutations in the APC gene and their phenotypic spectrum in familial adenomatous polyposis kindreds. 24
9341879 1997
121
Adrenal masses in patients with familial adenomatous polyposis. 24
9293929 1997
122
Gastric adenocarcinoma and dysplasia in fundic gland polyps of a patient with attenuated adenomatous polyposis coli. 24
9247488 1997
123
Cleaning up on beta-catenin. 24
9142114 1997
124
Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein. 24
9096341 1997
125
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. 24
9065401 1997
126
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. 24
9065402 1997
127
Stabilization of beta-catenin by genetic defects in melanoma cell lines. 24
9065403 1997
128
Beta-catenin as oncogene: the smoking gun. 24
9122680 1997
129
The use and interpretation of commercial APC gene testing for familial adenomatous polyposis. 24
9062090 1997
130
NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion. 24
9024698 1997
131
Hereditary desmoid disease due to a frameshift mutation at codon 1924 of the APC gene. 24
8940264 1996
132
Familial infiltrative fibromatosis (desmoid tumours) (MIM135290) caused by a recurrent 3' APC gene mutation. 24
8968744 1996
133
Germline mutations in the 3' part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli. 24
8931709 1996
134
Desmoids in familial adenomatous polyposis. 24
9014661 1996
135
Molecular genetic tests as a guide to surgical management of familial adenomatous polyposis. 24
8709782 1996
136
The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. 24
8698812 1996
137
Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. 24
8638125 1996
138
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. 24
8638126 1996
139
Attenuated familial adenomatous polyposis due to a mutation in the 3' part of the APC gene. A clue for understanding the function of the APC protein. 24
8655134 1996
140
The incidence rate of familial adenomatous polyposis. Results from the Danish Polyposis Register. 24
8739833 1996
141
APC mutation in the alternatively spliced region of exon 9 associated with late onset familial adenomatous polyposis. 24
8522331 1995
142
Multiple familial pilomatricomas: a cutaneous marker for Gardner syndrome? 24
8747580 1995
143
APC binds to the novel protein EB1. 24
7606712 1995
144
The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin. 24
7890674 1995
145
The molecular basis of Turcot's syndrome. 24
7661930 1995
146
Duodenal adenomatosis in familial adenomatous polyposis. DAF Project Group. 24
7745323 1995
147
Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection. 24
7833051 1994
148
Wild-type but not mutant APC associates with the microtubule cytoskeleton. 24
8033082 1994
149
The APC gene product associates with microtubules in vivo and promotes their assembly in vitro. 24
8033083 1994
150
Phenotypic variability of familial adenomatous polyposis in 11 unrelated families with identical APC gene mutation. 24
8194700 1994
151
Familial adenomatous polyposis (FAP): frequency, penetrance, and mutation rate. 24
8199592 1994
152
Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis. 24
8298943 1993
153
Association of the APC gene product with beta-catenin. 24
8259518 1993
154
Association of the APC tumor suppressor protein with catenins. 24
8259519 1993
155
Alleles of the APC gene: an attenuated form of familial polyposis. 24
8252630 1993
156
Dimer formation by an N-terminal coiled coil in the APC protein. 24
8248216 1993
157
Increased risk of thyroid and pancreatic carcinoma in familial adenomatous polyposis. 24
8244108 1993
158
Non-penetrance and late appearance of polyps in families with familial adenomatous polyposis. 24
8244107 1993
159
Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. 24
8385741 1993
160
The APC gene product in normal and tumor cells. 24
8385345 1993
161
APC mutations occur early during colorectal tumorigenesis. 24
1528264 1992
162
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. 24
1338904 1992
163
Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients. 24
1319838 1992
164
Hereditary flat adenoma syndrome: a variant of familial adenomatous polyposis? 24
1314729 1992
165
Epidemiology of familial adenomatous polyposis in Finland: impact of family screening on the colorectal cancer rate and survival. 24
1314763 1992
166
Sulindac causes regression of rectal polyps in familial adenomatous polyposis. 24
1650315 1991
167
Screening guidelines and premorbid diagnosis of familial adenomatous polyposis using linkage. 24
1673441 1991
168
Fertility and pregnancy in women with familial adenomatous polyposis. 24
1962811 1990
169
A genetic model for colorectal tumorigenesis. 24
2188735 1990
170
Upper gastrointestinal cancer in patients with familial adenomatous polyposis. 24
2571019 1989
171
Multiple cutaneous and subcutaneous lesions occurring simultaneously with hereditary polyposis and osteomatosis. 24
13065261 1953
172
A genetic and clinical study of intestinal polyposis, a predisposing factor for carcinoma of the colon and rectum. 24
14902760 1951
173
APC-Associated Polyposis Conditions 61
20301519 1998

Variations for Apc-Associated Polyposis Conditions

Expression for Apc-Associated Polyposis Conditions

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