Apc-Associated Polyposis Conditions disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: APC006 MIFTS: 12	Apc-Associated Polyposis Conditions
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Aliases & Classifications for Apc-Associated Polyposis Conditions

MalaCards integrated aliases for Apc-Associated Polyposis Conditions:

Name: Apc-Associated Polyposis Conditions ²⁴

Characteristics:

GeneReviews:

²⁴

Penetrance In fap, the penetrance of colonic adenomatous polyposis and colon cancer is virtually 100% in untreated individuals....

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Summaries for Apc-Associated Polyposis Conditions

MalaCards based summary : Apc-Associated Polyposis Conditions is related to colorectal cancer and familial adenomatous polyposis 1. An important gene associated with Apc-Associated Polyposis Conditions is APC (APC Regulator Of WNT Signaling Pathway). Affiliated tissues include colon, thyroid and testes.

GeneReviews: NBK1345

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Related Diseases for Apc-Associated Polyposis Conditions

Diseases related to Apc-Associated Polyposis Conditions via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 9, show less)

#	Related Disease	Score
1	colorectal cancer	10.1
2	familial adenomatous polyposis 1	10.1
3	polyposis of gastric fundus without polyposis coli	10.1
4	familial adenomatous polyposis	10.1
5	gastric adenocarcinoma	10.1
6	adenoma	10.1
7	hepatoblastoma	10.1
8	gastric adenocarcinoma and proximal polyposis of the stomach	10.1
9	thyroid carcinoma	10.1

Graphical network of the top 20 diseases related to Apc-Associated Polyposis Conditions:

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Symptoms & Phenotypes for Apc-Associated Polyposis Conditions

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Drugs & Therapeutics for Apc-Associated Polyposis Conditions

Search Clinical Trials , NIH Clinical Center for Apc-Associated Polyposis Conditions

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Genetic Tests for Apc-Associated Polyposis Conditions

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Anatomical Context for Apc-Associated Polyposis Conditions

MalaCards organs/tissues related to Apc-Associated Polyposis Conditions:

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Colon, Thyroid, Testes, Skin

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Publications for Apc-Associated Polyposis Conditions

Articles related to Apc-Associated Polyposis Conditions:

(showing 173, show less)

#	Title	Authors	PMID	Year
1	The first European family with gastric adenocarcinoma and proximal polyposis of the stomach: case report and review of the literature. ²⁴	Repak R...Bures J	27343414	2016
2	Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology. ²⁴	Provenzale D...Darlow S	27496117	2016
3	Exome Sequencing Identifies Biallelic MSH3 Germline Mutations as a Recessive Subtype of Colorectal Adenomatous Polyposis. ²⁴	Adam R...Aretz S	27476653	2016
4	Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant. ²⁴	Li J...Chenevix-Trench G	27087319	2016
5	Effect of Sulindac and Erlotinib vs Placebo on Duodenal Neoplasia in Familial Adenomatous Polyposis: A Randomized Clinical Trial. ²⁴	Samadder NJ...Kuwada SK	27002448	2016
6	Low-level APC mutational mosaicism is the underlying cause in a substantial fraction of unexplained colorectal adenomatous polyposis cases. ²⁴	Spier I...Aretz S	26613750	2016
7	The Contribution of Whole Gene Deletions and Large Rearrangements to the Mutation Spectrum in Inherited Tumor Predisposing Syndromes. ²⁴	Smith MJ...Evans DG	26615784	2016
8	An international randomised trial of celecoxib versus celecoxib plus difluoromethylornithine in patients with familial adenomatous polyposis. ²⁴	Lynch PM...Hawk E	25792707	2016
9	Biallelic NTHL1 Mutations in a Woman with Multiple Primary Tumors. ²⁴	Rivera B...Foulkes WD	26559593	2015
10	Cribriform-morular variant of papillary thyroid carcinoma. ²⁴	Pradhan D...Mohanty SK	26293799	2015
11	A germline homozygous mutation in the base-excision repair gene NTHL1 causes adenomatous polyposis and colorectal cancer. ²⁴	Weren RD...Hoogerbrugge N	25938944	2015
12	Hereditary colorectal cancer syndromes: American Society of Clinical Oncology clinical practice guideline endorsement of the familial risk-colorectal cancer: European Society for Medical Oncology clinical practice guidelines. ²⁴	Stoffel EM...European Society for Medical Oncology	25829526	2015
13	Desmoids and genotype in familial adenomatous polyposis. ²⁴	Church J...Kalady M	25751801	2015
14	APC rearrangements in familial adenomatous polyposis: heterogeneity of deletion lengths and breakpoint sequences underlies similar phenotypes. ²⁴	Quadri M...Ranzani GN	25159889	2015
15	ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes. ²⁴	Syngal S...American College of Gastroenterology	25645574	2015
16	FAP Associated Papillary Thyroid Carcinoma: A Peculiar Subtype of Familial Nonmedullary Thyroid Cancer. ²⁴	Cetta F	26697262	2015
17	Therapy-associated polyposis as a late sequela of cancer treatment. ²⁴	Yurgelun MB...Syngal S	24362051	2014
18	Wnt signaling in adult intestinal stem cells and cancer. ²⁴	Krausova M...Korinek V	24308963	2014
19	Preventive effects of low-dose aspirin on colorectal adenoma growth in patients with familial adenomatous polyposis: double-blind, randomized clinical trial. ²⁴	Ishikawa H...Sakai T	24133627	2013
20	The prevalence of thyroid cancer and benign thyroid disease in patients with familial adenomatous polyposis may be higher than previously recognized. ²⁴	Steinhagen E...Markowitz AJ	22425061	2012
21	Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): a new autosomal dominant syndrome. ²⁴	Worthley DL...Suthers GK	21813476	2012
22	Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1. ²⁴	Jaeger E...Tomlinson I	22561515	2012
23	Inactivation of promoter 1B of APC causes partial gene silencing: evidence for a significant role of the promoter in regulation and causative of familial adenomatous polyposis. ²⁴	Rohlin A...Nordling M	21643010	2011
24	Risk factors predicting desmoid occurrence in patients with familial adenomatous polyposis: a meta-analysis. ²⁴	Sinha A...Clark SK	20528895	2011
25	Constitutional mismatch repair-deficiency syndrome presenting as colonic adenomatous polyposis: clues from the skin. ²⁴	Jasperson KW...Burt RW	21039432	2011
26	A nation-wide study comparing sporadic and familial adenomatous polyposis-related desmoid-type fibromatoses. ²⁴	Nieuwenhuis MH...Vasen HF	20830713	2011
27	A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis. ²⁴	Burn J...International CAPP consortium	21543343	2011
28	Screening for thyroid cancer in patients with familial adenomatous polyposis. ²⁴	Jarrar AM...Church JM	21173694	2011
29	Defining phenotypes and cancer risk in hyperplastic polyposis syndrome. ²⁴	Kalady MF...Church JM	21228663	2011
30	Prevalence of skin lesions in familial adenomatous polyposis: a marker for presymptomatic diagnosis? ²⁴	Burger B...Heinimann K	22135120	2011
31	Population prevalence of familial cancer and common hereditary cancer syndromes. The 2005 California Health Interview Survey. ²⁴	Scheuner MT...Freedman AN	20921897	2010
32	Jejunal cancer in patients with familial adenomatous polyposis. ²⁴	Ruys AT...Mathus-Vliegen EM	20399906	2010
33	Female fertility after colorectal surgery for familial adenomatous polyposis: a nationwide cross-sectional study. ²⁴	Nieuwenhuis MH...Vasen HF	20622653	2010
34	Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis. ²⁴	West NJ...Hull MA	20348368	2010
35	Adrenocortical Secreting Mass in a Patient with Gardner's Syndrome: A Case Report. ²⁴	Rekik NM...Abid M	21209732	2010
36	Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial. ²⁴	Meyskens FL...Gerner EW	18841250	2008
37	Fundic gland polyp dysplasia is common in familial adenomatous polyposis. ²⁴	Bianchi LK...Church JM	18237868	2008
38	Gastric adenocarcinoma arising from fundic gland polyps in a patient with familial adenomatous polyposis syndrome. ²⁴	Garrean S...Espat NJ	18274437	2008
39	Somatic APC mosaicism: an underestimated cause of polyposis coli. ²⁴	Hes FJ...Tops CM	17604324	2008
40	Gonadal mosaicism and familial adenomatous polyposis. ²⁴	Schwab AL...Burt RW	18026870	2008
41	American founder mutation for attenuated familial adenomatous polyposis. ²⁴	Neklason DW...Burt RW	18063416	2008
42	Familial adenomatous polyposis in a patient with unexplained mental retardation. ²⁴	Heald B...Eng C	18046442	2007
43	Genotype-phenotype correlations in 19 Dutch cases with APC gene deletions and a literature review. ²⁴	Nielsen M...Weiss MM	17568392	2007
44	Somatic APC mosaicism: a frequent cause of familial adenomatous polyposis (FAP). ²⁴	Aretz S...Friedl W	17486639	2007
45	Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP. ²⁴	Suraweera N...Silver A	17496195	2007
46	Constitutive deficiency in DNA mismatch repair: is it time for Lynch III? ²⁴	Felton KE...Andrew SE	17539898	2007
47	Germline mutations in APC and MUTYH are responsible for the majority of families with attenuated familial adenomatous polyposis. ²⁴	Nielsen M...Vasen HF	17489848	2007
48	Prevalence of thyroid cancer in familial adenomatous polyposis syndrome and the role of screening ultrasound examinations. ²⁴	Herraiz M...Chung DC	17258512	2007
49	Strategies and outcomes of PGD of familial adenomatous polyposis. ²⁴	Moutou C...Viville S	17114207	2007
50	Correlations between mutation site in APC and phenotype of familial adenomatous polyposis (FAP): a review of the literature. ²⁴	Nieuwenhuis MH...Vasen HF	17064931	2007
51	Implication of MYH in colorectal polyposis. ²⁴	Lefevre JH...Parc YR	17122612	2006
52	Preimplantation genetic diagnosis of familial adenomatous polyposis. ²⁴	Davis T...Cram DS	17169185	2006
53	An evidence-based, multidisciplinary approach to the clinical considerations, management, and surveillance of adrenal lesions in familial adenomatous polyposis: report of three cases. ²⁴	Ferrandez A...Burt RW	17041748	2006
54	ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes. ²⁴	Guillem JG...SSO	17008706	2006
55	Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation. ²⁴	Sieber OM...Tomlinson IP	16461775	2006
56	Tumour surveillance in Beckwith-Wiedemann syndrome and hemihyperplasia: a critical review of the evidence and suggested guidelines for local practice. ²⁴	Tan TY...Amor DJ	16925531	2006
57	Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. ²⁴	Cruz-Correa M...Giardiello FM	16757216	2006
58	MUTYH-associated polyposis: 70 of 71 patients with biallelic mutations present with an attenuated or atypical phenotype. ²⁴	Aretz S...Friedl W	16557584	2006
59	Congenital hypertrophy of the retinal pigment epithelium (CHRPE) in familial colorectal cancer. ²⁴	Chen CS...Suthers GK	16944273	2006
60	Successful chemotherapeutic modality of doxorubicin plus dacarbazine for the treatment of desmoid tumors in association with familial adenomatous polyposis. ²⁴	Gega M...Yamamura T	16382119	2006
61	Familial adenomatous polyposis: experience from a study of 1164 unrelated german polyposis patients. ²⁴	Friedl W...Aretz S	20223039	2005
62	Phenotype associated with recessively inherited mutations in DNA mismatch repair (MMR) genes. ²⁴	de Vos M...Sheridan E	16042583	2005
63	Oral contraceptives and polyp regression in familial adenomatous polyposis. ²⁴	Giardiello FM...Yang VW	15825088	2005
64	Prevalence and morphology of pouch and ileal adenomas in familial adenomatous polyposis. ²⁴	Groves CJ...Phillips RK	15747076	2005
65	Large deletions of the APC gene in 15% of mutation-negative patients with classical polyposis (FAP): a Belgian study. ²⁴	Michils G...Matthijs G	15643602	2005
66	Large submicroscopic genomic APC deletions are a common cause of typical familial adenomatous polyposis. ²⁴	Aretz S...Friedl W	15689459	2005
67	A comparison of the phenotype and genotype in adenomatous polyposis patients with and without a family history. ²⁴	Truta B...Terdiman JP	15951963	2005
68	Dosage analysis of cancer predisposition genes by multiplex ligation-dependent probe amplification. ²⁴	Bunyan DJ...Cross NC	15475941	2004
69	Genetic testing and phenotype in a large kindred with attenuated familial adenomatous polyposis. ²⁴	Burt RW...White RL	15300576	2004
70	A clinical overview of familial adenomatous polyposis derived from the database of the Polyposis Registry of Japan. ²⁴	Iwama T...Japanese Society for Cancer of the Colon and Rectum	15375708	2004
71	MYH mutations in patients with attenuated and classic polyposis and with young-onset colorectal cancer without polyps. ²⁴	Wang L...Thibodeau SN	15236166	2004
72	Gastric fundic gland polyps. ²⁴	Burt RW	14598262	2003
73	Anal transitional zone cancer after restorative proctocolectomy and ileoanal anastomosis in familial adenomatous polyposis: report of two cases. ²⁴	Ooi BS...Fazio VW	14530685	2003
74	A prospective study of the clinical, genetic, screening, and pathologic features of a family with hereditary mixed polyposis syndrome. ²⁴	Rozen P...Brazowski E	14572586	2003
75	Risk of rectal cancer in patients after colectomy and ileorectal anastomosis for familial adenomatous polyposis: a function of available surgical options. ²⁴	Church J...Clark B	12972960	2003
76	Practice parameters for the treatment of patients with dominantly inherited colorectal cancer (familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer). ²⁴	Church J...Collaborative Group of the Americas on Inherited Colorectal Cancer and the Standards Committee of The American Society of Colon and Rectal Surgeons	12907889	2003
77	Treatment of desmoids and mesenteric fibromatosis in familial adenomatous polyposis with raloxifene. ²⁴	Tonelli F...Brandi ML	14606641	2003
78	Multiple approach to the exploration of genotype-phenotype correlations in familial adenomatous polyposis. ²⁴	Bertario L...Hereditary Colorectal Tumor Registry	12721244	2003
79	Stepwise progression of familial adenomatous polyposis-associated desmoid precursor lesions demonstrated by a novel CT scoring system. ²⁴	Middleton SB...Phillips RK	12682541	2003
80	Female fecundity before and after operation for familial adenomatous polyposis. ²⁴	Olsen KO...Laurberg S	12555301	2003
81	Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. ²⁴	Etienne-Manneville S...Hall A	12610628	2003
82	Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH. ²⁴	Sieber OM...Tomlinson IP	12606733	2003
83	Genetic testing for hereditary colorectal cancer in children: long-term psychological effects. ²⁴	Codori AM...Giardiello FM	12494429	2003
84	Genotype and phenotype of patients with both familial adenomatous polyposis and thyroid carcinoma. ²⁴	Truta B...Sleisenger MH	14574158	2003
85	Attenuated familial adenomatous polyposis (AFAP). A review of the literature. ²⁴	Knudsen AL...Bulow S	14574166	2003
86	Preimplantation genetic diagnosis for cancer predisposition. ²⁴	Rechitsky S...Verlinsky Y	12419039	2002
87	Challenge in the differentiation between attenuated familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer: case report with review of the literature. ²⁴	Cao Y...Lynch H	12135043	2002
88	A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis. ²⁴	Phillips RK...FAP Study Group	12010890	2002
89	Primary chemoprevention of familial adenomatous polyposis with sulindac. ²⁴	Giardiello FM...Hamilton SR	11932472	2002
90	Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas. ²⁴	Sieber OM...Heinimann K	11867715	2002
91	Gardner-associated fibromas (GAF) in young patients: a distinct fibrous lesion that identifies unsuspected Gardner syndrome and risk for fibromatosis. ²⁴	Wehrli BM...Coffin CM	11342777	2001
92	Duodenal adenomatosis in familial adenomatous polyposis coli. A review of the literature and results from the Heidelberg Polyposis Register. ²⁴	Kadmon M...Herfarth C	11355321	2001
93	Can APC mutation analysis contribute to therapeutic decisions in familial adenomatous polyposis? Experience from 680 FAP families. ²⁴	Friedl W...Propping P	11247896	2001
94	A role for the Adenomatous Polyposis Coli protein in chromosome segregation. ²⁴	Kaplan KB...Nathke IS	11283619	2001
95	Mutations in the APC tumour suppressor gene cause chromosomal instability. ²⁴	Fodde R...Clevers H	11283620	2001
96	Genotype and phenotype factors as determinants of desmoid tumors in patients with familial adenomatous polyposis. ²⁴	Bertario L...Hereditary Colorectal Tumours Registry	11241320	2001
97	Fundic gland polyposis with high-grade dysplasia in a child with attenuated familial adenomatous polyposis and familial gastric cancer. ²⁴	Attard TM...Cuffari C	11321399	2001
98	Impact of screening examinations on survival in familial adenomatous polyposis. ²⁴	Heiskanen I...Jarvinen HJ	11199368	2000
99	Adrenal masses are associated with familial adenomatous polyposis. ²⁴	Smith TG...Phillips RK	11156460	2000
100	The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis. ²⁴	Chung DC	10982779	2000
101	The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. ²⁴	Steinbach G...Kelloff G	10874062	2000
102	Biology of the adenomatous polyposis coli tumor suppressor. ²⁴	Goss KH...Groden J	10784639	2000
103	Surgical management of intra-abdominal desmoid tumours. ²⁴	Smith AJ...Brennan MF	10792318	2000
104	Prior pregnancy ameliorates the course of intra-abdominal desmoid tumors in patients with familial adenomatous polyposis. ²⁴	Church JM...McGannon E	10789737	2000
105	A germline mutation at the extreme 3' end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor. ²⁴	Couture J...Bapat B	10782927	2000
106	UMD (Universal mutation database): a generic software to build and analyze locus-specific databases. ²⁴	Beroud C...Junien C	10612827	2000
107	Germline mutations of the APC gene in patients with familial adenomatous polyposis-associated thyroid carcinoma: results from a European cooperative study. ²⁴	Cetta F...Olschwang S	10634400	2000
108	Epidemiology of familial adenomatous polyposis in Sweden: changes over time and differences in phenotype between males and females. ²⁴	Bjork J...Hultcrantz R	10636071	1999
109	Notable intrafamilial phenotypic variability in a kindred with familial adenomatous polyposis and an APC mutation in exon 9. ²⁴	Rozen P...Legum C	10562580	1999
110	Attenuated familial adenomatous polyposis in a man with an interstitial deletion of chromosome arm 5q. ²⁴	Pilarski RT...Shulman Rosengren S	10494086	1999
111	Desmoid tumours complicating familial adenomatous polyposis. ²⁴	Clark SK...Phillips RK	10504375	1999
112	Management of duodenal adenomas in familial adenomatous polyposis. ²⁴	Saurin JC...Ponchon T	10494690	1999
113	Gastric adenocarcinoma associated with fundic gland polyps in a patient with attenuated familial adenomatous polyposis. ²⁴	Hofgartner WT...Lobitz JR	10445562	1999
114	Upper gastrointestinal polyps in familial adenomatous polyposis. ²⁴	Offerhaus GJ...Giardiello FM	10370594	1999
115	Molecular analysis of the APC gene in 205 families: extended genotype-phenotype correlations in FAP and evidence for the role of APC amino acid changes in colorectal cancer predisposition. ²⁴	Wallis YL...Macdonald F	9950360	1999
116	Upper gastrointestinal disease in patients with familial adenomatous polyposis. ²⁴	Wallace MH...Phillips RK	9667698	1998
117	Genotype-phenotype correlations in attenuated adenomatous polyposis coli. ²⁴	Soravia C...Bapat B	9585611	1998
118	Cost analysis of alternative approaches to colorectal screening in familial adenomatous polyposis. ²⁴	Cromwell DM...Giardiello FM	9558276	1998
119	Extracolonic manifestations of familial adenomatous polyposis: desmoid tumours, and upper gastrointestinal adenomas and carcinomas. ²⁴	Griffioen G...Lamers CB	9515758	1998
120	Novel germline mutations in the APC gene and their phenotypic spectrum in familial adenomatous polyposis kindreds. ²⁴	Walon C...Verellen-Dumoulin C	9341879	1997
121	Adrenal masses in patients with familial adenomatous polyposis. ²⁴	Marchesa P...McGannon E	9293929	1997
122	Gastric adenocarcinoma and dysplasia in fundic gland polyps of a patient with attenuated adenomatous polyposis coli. ²⁴	Zwick A...Chey WY	9247488	1997
123	Cleaning up on beta-catenin. ²⁴	Nakamura Y	9142114	1997
124	Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein. ²⁴	Neufeld KL...White RL	9096341	1997
125	Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. ²⁴	Korinek V...Clevers H	9065401	1997
126	Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. ²⁴	Morin PJ...Kinzler KW	9065402	1997
127	Stabilization of beta-catenin by genetic defects in melanoma cell lines. ²⁴	Rubinfeld B...Polakis P	9065403	1997
128	Beta-catenin as oncogene: the smoking gun. ²⁴	Peifer M	9122680	1997
129	The use and interpretation of commercial APC gene testing for familial adenomatous polyposis. ²⁴	Giardiello FM...Hamilton SR	9062090	1997
130	NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion. ²⁴	Barth AI...Nelson WJ	9024698	1997
131	Hereditary desmoid disease due to a frameshift mutation at codon 1924 of the APC gene. ²⁴	Eccles DM...Fodde R	8940264	1996
132	Familial infiltrative fibromatosis (desmoid tumours) (MIM135290) caused by a recurrent 3' APC gene mutation. ²⁴	Scott RJ...Maher ER	8968744	1996
133	Germline mutations in the 3' part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli. ²⁴	van der Luijt RB...Fodde R	8931709	1996
134	Desmoids in familial adenomatous polyposis. ²⁴	Clark SK...Phillips RK	9014661	1996
135	Molecular genetic tests as a guide to surgical management of familial adenomatous polyposis. ²⁴	Vasen HF...Meera Khan P	8709782	1996
136	The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. ²⁴	Nathke IS...Nelson WJ	8698812	1996
137	Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. ²⁴	Matsumine A...Akiyama T	8638125	1996
138	Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. ²⁴	Rubinfeld B...Polakis P	8638126	1996
139	Attenuated familial adenomatous polyposis due to a mutation in the 3' part of the APC gene. A clue for understanding the function of the APC protein. ²⁴	Friedl W...Propping P	8655134	1996
140	The incidence rate of familial adenomatous polyposis. Results from the Danish Polyposis Register. ²⁴	Bulow S...Moesgaard F	8739833	1996
141	APC mutation in the alternatively spliced region of exon 9 associated with late onset familial adenomatous polyposis. ²⁴	van der Luijt RB...Meera Khan P	8522331	1995
142	Multiple familial pilomatricomas: a cutaneous marker for Gardner syndrome? ²⁴	Pujol RM...de Moragas JM	8747580	1995
143	APC binds to the novel protein EB1. ²⁴	Su LK...Kinzler KW	7606712	1995
144	The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin. ²⁴	Rubinfeld B...Polakis P	7890674	1995
145	The molecular basis of Turcot's syndrome. ²⁴	Hamilton SR...Tetu B	7661930	1995
146	Duodenal adenomatosis in familial adenomatous polyposis. DAF Project Group. ²⁴	Bulow S...Vasen H	7745323	1995
147	Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection. ²⁴	Hulsken J...Birchmeier W	7833051	1994
148	Wild-type but not mutant APC associates with the microtubule cytoskeleton. ²⁴	Smith KJ...Kinzler KW	8033082	1994
149	The APC gene product associates with microtubules in vivo and promotes their assembly in vitro. ²⁴	Munemitsu S...Polakis P	8033083	1994
150	Phenotypic variability of familial adenomatous polyposis in 11 unrelated families with identical APC gene mutation. ²⁴	Giardiello FM...Hamilton SR	8194700	1994
151	Familial adenomatous polyposis (FAP): frequency, penetrance, and mutation rate. ²⁴	Bisgaard ML...Mohr J	8199592	1994
152	Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis. ²⁴	Nugent KP...Phillips RK	8298943	1993
153	Association of the APC gene product with beta-catenin. ²⁴	Rubinfeld B...Polakis P	8259518	1993
154	Association of the APC tumor suppressor protein with catenins. ²⁴	Su LK...Kinzler KW	8259519	1993
155	Alleles of the APC gene: an attenuated form of familial polyposis. ²⁴	Spirio L...Otterud B	8252630	1993
156	Dimer formation by an N-terminal coiled coil in the APC protein. ²⁴	Joslyn G...Alber T	8248216	1993
157	Increased risk of thyroid and pancreatic carcinoma in familial adenomatous polyposis. ²⁴	Giardiello FM...Hamilton SR	8244108	1993
158	Non-penetrance and late appearance of polyps in families with familial adenomatous polyposis. ²⁴	Evans DG...Sloan P	8244107	1993
159	Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. ²⁴	Giardiello FM...Offerhaus GJ	8385741	1993
160	The APC gene product in normal and tumor cells. ²⁴	Smith KJ...Vogelstein B	8385345	1993
161	APC mutations occur early during colorectal tumorigenesis. ²⁴	Powell SM...Kinzler KW	1528264	1992
162	Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. ²⁴	Miyoshi Y...Nakamura Y	1338904	1992
163	Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients. ²⁴	Nagase H...Nakamura Y	1319838	1992
164	Hereditary flat adenoma syndrome: a variant of familial adenomatous polyposis? ²⁴	Lynch HT...Lynch J	1314729	1992
165	Epidemiology of familial adenomatous polyposis in Finland: impact of family screening on the colorectal cancer rate and survival. ²⁴	Jarvinen HJ	1314763	1992
166	Sulindac causes regression of rectal polyps in familial adenomatous polyposis. ²⁴	Labayle D...Attali P	1650315	1991
167	Screening guidelines and premorbid diagnosis of familial adenomatous polyposis using linkage. ²⁴	Petersen GM...Nakamura Y	1673441	1991
168	Fertility and pregnancy in women with familial adenomatous polyposis. ²⁴	Johansen C...Bulow S	1962811	1990
169	A genetic model for colorectal tumorigenesis. ²⁴	Fearon ER...Vogelstein B	2188735	1990
170	Upper gastrointestinal cancer in patients with familial adenomatous polyposis. ²⁴	Spigelman AD...Phillips RK	2571019	1989
171	Multiple cutaneous and subcutaneous lesions occurring simultaneously with hereditary polyposis and osteomatosis. ²⁴	GARDNER EJ...RICHARDS RC	13065261	1953
172	A genetic and clinical study of intestinal polyposis, a predisposing factor for carcinoma of the colon and rectum. ²⁴	GARDNER EJ	14902760	1951
173	APC-Associated Polyposis Conditions ⁶¹	Jasperson KW...Ahnen DJ	20301519	1998

Sources

Genes for Apc-Associated Polyposis Conditions

Genes related to Apc-Associated Polyposis Conditions (0 elite genes):

(showing 1, show less)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	APC	APC Regulator Of WNT Signaling Pathway	Protein Coding	6.53	GeneCards inferred via : Publications (show sections)

Sources

Variations for Apc-Associated Polyposis Conditions

Sources

Expression for Apc-Associated Polyposis Conditions

Search GEO for disease gene expression data for Apc-Associated Polyposis Conditions.

Sources

Pathways for Apc-Associated Polyposis Conditions

Sources

GO Terms for Apc-Associated Polyposis Conditions

Sources

Sources for Apc-Associated Polyposis Conditions

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia