Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: APH002
MIFTS: 60

Aphasia

Categories: Mental diseases, Neuronal diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Aphasia

About this section

MalaCards integrated aliases for Aphasia:

Name: Aphasia 12 30 56 6 44 45 15 74

Classifications:

MalaCards categories:
Anatomical: Mental diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060046
MeSH 45 D001037
UMLS 74 C0003537
Sources

Summaries for Aphasia

About this section
NINDS : 55 Aphasia is a neurological disorder caused by damage to the portions of the brain that are responsible for language production or processing.  It may occur suddenly or progressively, depending on the type and location of brain tissue involved.  Primary signs of the disorder include difficulty in expressing oneself when speaking, trouble understanding speech, and difficulty with reading and writing. Aphasia is not a disease, but a symptom of brain damage. Although it is primarily seen in individuals who have suffered a stroke, aphasia can also result from a brain tumor, infection, inflammation, head injury, or dementia that affect language-associated regions of the brain. It is estimated that about 1 million people in the United States today suffer from aphasia. The type and severity of language dysfunction depends on the precise location and extent of the damaged brain tissue. Generally, aphasia can be divided into four broad categories: (1) Expressive aphasia (also called Broca's aphasia) involves difficulty in conveying thoughts through speech or writing. The person knows what she/he wants to say, but cannot find the words he needs. (2) Receptive aphasia (Wernicke's aphasia) involves difficulty understanding spoken or written language. The individual hears the voice or sees the print but cannot make sense of the words. (3) Global aphasia results from severe and extensive damage to the language areas of the brain.  People lose almost all language function, both comprehension and expression. They cannot speak or understand speech, nor can they read or write.  (4) Indiivfduals with anomic or amnesia aphasia, the least severe form of aphasia, have difficulty in using the correct names for particular objects, people, places, or events.

MalaCards based summary : Aphasia is related to frontotemporal lobar degeneration with tdp43 inclusions, grn-related and epilepsy-aphasia spectrum, and has symptoms including seizures, tremor and fever. An important gene associated with Aphasia is L1CAM (L1 Cell Adhesion Molecule), and among its related pathways/superpathways are Neuroscience and Reelin Pathway (Cajal-Retzius cells). The drugs Dopamine and Memantine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related phenotypes are behavior/neurological and nervous system

Disease Ontology : 12 A language disorder that involves an acquired impairment of any laguage modality such as producting or comprehending spoken or written language.

MedlinePlus : 44 Aphasia is a disorder caused by damage to the parts of the brain that control language. It can make it hard for you to read, write, and say what you mean to say. It is most common in adults who have had a stroke. Brain tumors, infections, injuries, and dementia can also cause it. The type of problem you have and how bad it is depends on which part of your brain is damaged and how much damage there is. There are four main types: Expressive aphasia - you know what you want to say, but you have trouble saying or writing what you mean Receptive aphasia - you hear the voice or see the print, but you can't make sense of the words Anomic aphasia - you have trouble using the correct word for objects, places, or events Global aphasia - you can't speak, understand speech, read, or write Some people recover from aphasia without treatment. Most, however, need language therapy as soon as possible. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 77 Aphasia is an inability to comprehend or formulate language because of damage to specific brain regions.... more...

Sources

Related Diseases for Aphasia

About this section

Diseases related to Aphasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 238)
# Related Disease Score Top Affiliating Genes
1 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 34.1 GRN MAPT
2 epilepsy-aphasia spectrum 34.1 CNKSR2 GRIN2A
3 nominal aphasia 34.0 CHMP2B GRN MAPT PSEN1
4 progressive non-fluent aphasia 33.6 C9orf72 CHMP2B GRN MAPT PSEN1
5 semantic dementia 32.6 APOE C9orf72 CHMP2B GRN MAPT PSEN1
6 agraphia 32.2 GRN MAPT PRNP PSEN1
7 pick disease of brain 32.2 APOE APP GRN MAPT PSEN1
8 supranuclear palsy, progressive, 1 32.0 APOE APP GRN MAPT
9 apraxia 31.7 C9orf72 FOXP2 GRN MAPT PSEN1
10 frontotemporal dementia 31.4 APOE APP C9orf72 CHMP2B GRN MAPT
11 alexia 30.8 APOE PSEN1
12 ideomotor apraxia 30.7 GRN MAPT
13 associative agnosia 30.5 GRN PSEN1
14 creutzfeldt-jakob disease 30.5 APOE MAPT PRNP
15 echolalia 30.3 GRN MAPT PSEN1
16 posterior cortical atrophy 30.2 APOE MAPT
17 mutism 30.2 CHMP2B GRN
18 brain injury 30.2 APOE BDNF MAPT
19 visual agnosia 30.1 GRN PSEN1
20 akinetic mutism 30.0 MAPT PRNP
21 transient global amnesia 29.9 BDNF PRNP PSEN1
22 kluver-bucy syndrome 29.8 APP MAPT PSEN1
23 prion disease 29.8 APP MAPT PRNP
24 speech disorder 29.8 FOXP2 GRIN2A GRN
25 motor neuron disease 29.7 BDNF C9orf72 GRN MAPT
26 alzheimer disease 29.7 APOE APP BDNF GRIN2A GRN MAPT
27 cerebrovascular disease 29.5 APOE APP MAPT
28 dementia 29.5 APOE APP BDNF C9orf72 CHMP2B GRN
29 behavioral variant of frontotemporal dementia 29.4 C9orf72 CHMP2B GRN MAPT PSEN1
30 cerebral amyloid angiopathy, cst3-related 29.3 APOE APP MAPT PRNP PSEN1
31 amyotrophic lateral sclerosis 1 28.9 APP BDNF C9orf72 CHMP2B GRN MAPT
32 disease of mental health 28.5 APOE APP BDNF C9orf72 GRIN2A GRN
33 logopenic progressive aphasia 12.5
34 landau-kleffner syndrome 12.1
35 epilepsy, focal, with speech disorder and with or without mental retardation 12.0
36 progressive supranuclear palsy-progressive non-fluent aphasia syndrome 12.0
37 intellectual disability-expressive aphasia-facial dysmorphism syndrome 12.0
38 masa syndrome 11.9
39 gerstmann syndrome 11.8
40 spastic paraplegia 1 11.6
41 cerebral atrophy 11.5
42 moyamoya disease 1 11.3
43 progressive multifocal leukoencephalopathy 11.3
44 marchiafava bignami disease 11.3
45 autosomal dominant partial epilepsy with auditory features 11.1
46 sudanophilic cerebral sclerosis 10.9
47 frontotemporal dementia, chromosome 3-linked 10.9
48 handl syndrome 10.9
49 inclusion body myopathy with early-onset paget disease and frontotemporal dementia 10.9
50 spastic paraplegia 16 10.9

Graphical network of the top 20 diseases related to Aphasia:



Diseases related to Aphasia
Sources

Symptoms & Phenotypes for Aphasia

About this section

UMLS symptoms related to Aphasia:


seizures, tremor, fever, dyspnea, edema, back pain, cachexia, vertigo, pain, headache, syncope, scanning speech, cyanosis, chronic pain, sciatica, sore throat, icterus, signs and symptoms, signs and symptoms, digestive, other symbolic dysfunction, hot flushes, vertigo/dizziness, sleeplessness, other symptoms involving head and neck, swelling, mass, or lump in head and neck, aprosodia, aphasic, symptoms involving head and neck, other and unspecified speech disturbances, other speech disturbances, central nervous system signs and symptoms

MGI Mouse Phenotypes related to Aphasia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.17 APOE APP BDNF C9orf72 GRIN2A GRN
2 nervous system MP:0003631 10.1 APOE APP BDNF C9orf72 CHMP2B GRIN2A
3 cellular MP:0005384 10.06 APOE APP BDNF C9orf72 GRN L1CAM
4 integument MP:0010771 9.97 APOE APP BDNF GRIN2A L1CAM MAPT
5 no phenotypic analysis MP:0003012 9.86 APOE APP BDNF C9orf72 GRN L1CAM
6 reproductive system MP:0005389 9.7 APOE APP BDNF GRN L1CAM PRNP
7 vision/eye MP:0005391 9.17 APOE BDNF GRN L1CAM MAPT PRNP
8 taste/olfaction MP:0005394 9.13 APOE BDNF MAPT
Sources

Drugs & Therapeutics for Aphasia

About this section

Drugs for Aphasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 222)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 62-31-7, 51-61-6 681
2
Memantine Approved, Investigational Phase 4,Phase 3,Phase 2 19982-08-2 4054
3
tannic acid Approved Phase 4,Phase 3 1401-55-4
4
Donepezil Approved Phase 4 120014-06-4 3152
5
Benzocaine Approved, Investigational Phase 4,Phase 3 94-09-7, 1994-09-7 2337
6
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
7
Levodopa Approved Phase 4,Phase 2,Phase 3,Not Applicable 59-92-7 6047
8
Citalopram Approved Phase 4,Phase 2 59729-33-8 2771
9
Amantadine Approved Phase 4,Phase 2,Phase 3 768-94-5 2130
10
Testosterone Approved, Experimental, Investigational Phase 4 58-22-0, 481-30-1 6013 10204
11
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
12
Corticosterone Experimental Phase 4,Phase 1,Early Phase 1 50-22-6 5753
13 Antiparkinson Agents Phase 4,Phase 2,Phase 3,Not Applicable
14 Excitatory Amino Acids Phase 4,Phase 3,Phase 2
15 Dopamine Agents Phase 4,Phase 2,Phase 3,Not Applicable
16 Excitatory Amino Acid Antagonists Phase 4,Phase 3,Phase 2
17 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
18 Cholinergic Agents Phase 4,Phase 2,Not Applicable
19 Cholinesterase Inhibitors Phase 4,Phase 2,Not Applicable
20 Nootropic Agents Phase 4,Phase 2,Phase 1,Not Applicable
21 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Cardiotonic Agents Phase 4,Phase 2,Not Applicable
23 Sympathomimetics Phase 4,Phase 2,Not Applicable
24 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
26 Analgesics Phase 4,Phase 3,Phase 2
27 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
28 Anti-Inflammatory Agents Phase 4,Phase 3
29 Antirheumatic Agents Phase 4,Phase 3,Phase 2
30 Cyclooxygenase Inhibitors Phase 4,Phase 3
31 Antipyretics Phase 4,Phase 3
32 Fibrinolytic Agents Phase 4,Phase 3
33 Platelet Aggregation Inhibitors Phase 4,Phase 3,Not Applicable
34 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
35 Central Nervous System Depressants Phase 4,Phase 2,Phase 1,Not Applicable
36 Dopamine agonists Phase 4,Not Applicable
37 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1,Not Applicable
38 Serotonin Uptake Inhibitors Phase 4,Phase 2,Not Applicable
39 Antidepressive Agents Phase 4,Phase 2,Phase 1,Not Applicable
40 Psychotropic Drugs Phase 4,Phase 2,Phase 1,Not Applicable
41 Antidepressive Agents, Second-Generation Phase 4,Phase 2,Not Applicable
42 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2,Not Applicable
43 Serotonin Agents Phase 4,Phase 2,Not Applicable
44 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
45 Antiviral Agents Phase 4,Phase 2,Phase 3,Phase 1
46 Fluorodeoxyglucose F18 Phase 4,Phase 2,Phase 1
47 Androgens Phase 4
48 Soy Bean Phase 4
49 Hormone Antagonists Phase 4,Phase 3
50 Hormones Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 376)
# Name Status NCT ID Phase Drugs
1 Memantine and Constraint-Induced Language Therapy in Chronic Poststroke Aphasia:A Randomized Controlled Trial Unknown status NCT00196703 Phase 4 memantine
2 Effect of Memantine Oral Pump on Language in Patients With Probable Alzheimer's Disease Unknown status NCT01849042 Phase 4 Ebixa;donepezil
3 Memantine and Intensive Speech-Language Therapy in Aphasia Completed NCT00640198 Phase 4 memantine;memantine;placebo
4 Donepezil in Chronic Poststroke Aphasia: a Randomized Controlled Trial Completed NCT00196690 Phase 4 Donepezil
5 Dopaminergic Enhancement of Learning and Memory in Aphasia Completed NCT00102869 Phase 4 levodopa
6 A Study to Evaluate the Efficacy and Safety of Piracetam on Aphasia After Acute Ischemic Cerebral Artery Stroke Terminated NCT01883011 Phase 4 Piracetam
7 Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech Recruiting NCT01818661 Phase 4 AV-1451
8 Serotonergic Function and Behavioural and Psychological Symptoms of Frontotemporal Dementia Completed NCT00376051 Phase 4 Citalopram
9 Amantadine for the Treatment of Behavioral Disturbance in Frontotemporal Dementia (FTD) Withdrawn NCT00127114 Phase 4 Amantadine;Placebo
10 Memantine (10mg BID) for the Frontal and Temporal Subtypes of Frontotemporal Dementia Completed NCT00545974 Phase 4 memantine;Placebo pill
11 Imaging of Brain Amyloid Plaques in the Aging Population Enrolling by invitation NCT00950430 Phase 4 Pittsburgh Compound B (C-11 PiB);F-18 FDG;Tau (18-F-AV-1451)
12 Efficacy and Safety of Qizhitongluo Capsule in the Recovery Phase of Ischemic Stroke Completed NCT01762163 Phase 4 Qizhitongluo Capsule;Naoxintong Capsule;Aspirin Enteric-coated Tablets;placebo
13 Effect of Soy on Cognition and Hot Flashes in Men With Prostate Cancer Undergoing Testosterone Suppression Therapy Completed NCT00245518 Phase 4 Isoflavone;Placebos
14 An Efficacy and Safety Study of Long Acting Injectable Risperidone and Oral Risperidone in Participants With Schizophrenia or Schizoaffective Disorder Completed NCT00992407 Phase 4 Risperidone long acting injectables;Risperidone tablets
15 Effects of MTS-r on Speech Production in Non-fluent Aphasia Post-ischemic Stroke Patients Unknown status NCT02241213 Phase 3
16 Improvement of Language Disturbances After Stroke by Intensive Training and Electrical Brain Stimulation Unknown status NCT00822068 Phase 2, Phase 3
17 Safety Profile Evaluation of TICagrelor Alone Compared to a Combination of Lysine Acetylsalicylate-Clopidogrel in the Context of Transcatheter Aortic Valve Implantation (TAVI) Unknown status NCT02817789 Phase 3 Ticagrelor alone;Combination lysine acetylsalicylate - clopidogrel
18 Augmenting Language Therapy for Aphasia: Levodopa Completed NCT01429077 Phase 2, Phase 3 levodopa/carbidopa;Placebo comparator
19 Non-invasive Repetitive Paraorbital Alternating Current Stimulation Therapy for Aphasia Terminated NCT01277575 Phase 3
20 Melodic-Intonation-Therapy and Speech-Repetition-Therapy for Patients With Non-fluent Aphasia Recruiting NCT00903266 Phase 3
21 Action of Amantadine on Post-Stroke Aphasic Patients Completed NCT00821691 Phase 2, Phase 3 Amantadin;Placebo
22 Use of Local Intraoperative Steroid in MIS TLIF Active, not recruiting NCT03308084 Phase 3 Methylprednisolone;Dexamethasone
23 Non-vitamin K Antagonist Oral Anticoagulants in Patients With Atrial High Rate Episodes Recruiting NCT02618577 Phase 3 Edoxaban;ASA
24 Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke (DIAS-4) Terminated NCT00856661 Phase 3 Desmoteplase;Placebo
25 Oral HYCAMTIN Plus Whole Brain Radiation Therapy In Treatment Of Brain Metastases Resulting From Non-Small Lung Cancer Completed NCT00390806 Phase 3 HYCAMTIN, oral capsules
26 Safety and Efficacy Study Evaluating TRx0237 in Subjects With Behavioral Variant Frontotemporal Dementia (bvFTD) Completed NCT01626378 Phase 3 TRx0237;Placebo
27 Open Label Pilot Study of the Effects of Memantine on FDG-PET in Frontotemporal Dementia Completed NCT00594737 Phase 3 memantine hydrochloride
28 Open-Label Study of TRx0237 in Subjects With Alzheimer's Disease or Behavioral Variant Frontotemporal Dementia (bvFTD) Terminated NCT02245568 Phase 3 TRx0237
29 Arimoclomol Prospective Study in Patients Diagnosed With NiemannPick Disease Type C Active, not recruiting NCT02612129 Phase 2, Phase 3 arimoclomol;Placebo
30 Study of VTS-270 (2-hydroxypropyl-β-cyclodextrin) to Treat Niemann-Pick Type C1 (NPC1) Disease Active, not recruiting NCT02534844 Phase 2, Phase 3 VTS-270;Sham Procedure Control
31 Application of Miglustat in Patients With Niemann-Pick Type C Completed NCT01760564 Phase 3 Miglustat
32 Open-label Study of VTS-270 in Participants With Neurologic Manifestations of Niemann-Pick Type C1 Not yet recruiting NCT03879655 Phase 2, Phase 3 VTS-270
33 The Healthy Patterns Study Recruiting NCT03682185 Phase 3
34 Stem Cell Transplant for Inborn Errors of Metabolism Completed NCT00176904 Phase 2, Phase 3 Busulfan, Cyclophosphamide, Antithymocyte Globulin
35 iMRI Guided Resection in Cerebral Glioma Surgery Active, not recruiting NCT01479686 Phase 3
36 Intraventricular Fibrinolysis for Aneurysmal Subarachnoid Hemorrhage. Recruiting NCT03187405 Phase 3 EVD + IVF with Alteplase
37 Targeted Electrotherapy for Aphasia Stroke Rehabilitation (TEASER) - Phase II Multi-Center Study Unknown status NCT02540109 Phase 2
38 Chronic Aphasia - Improved by Intensive Training and Electrical Brain Stimulation (CATS) Unknown status NCT01924702 Phase 2
39 Chronic Aphasia - Improved by Intensive Training and Electrical Brain Stimulation Unknown status NCT01221779 Phase 2
40 Tau Brain Imaging in Typical and Atypical Alzheimer's Disease (AD) Unknown status NCT03022968 Phase 2 [18F]T807 PET
41 Study to Assess the Safety, Tolerability, and Pharmacodynamic (PD) Effects of FRM-0334 in Subjects With Prodromal to Moderate Frontotemporal Dementia With Granulin Mutation Unknown status NCT02149160 Phase 2 FRM-0334;Placebo
42 Effects of Tolcapone on Frontotemporal Dementia Unknown status NCT00604591 Phase 2 Tolcapone;Placebo
43 tDCS and Aphasia Therapy in the Chronic Phase After Stroke Not yet recruiting NCT03305614 Phase 2
44 tDCS and Aphasia Therapy in the Acute Phase After Stroke Terminated NCT03297450 Phase 2
45 Effect of Verb Network Strengthening Treatment (VNeST) on Lexical Retrieval in Aphasia Completed NCT01300624 Phase 2
46 Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Chronic Aphasia Recruiting NCT03651700 Phase 2
47 Evaluating Anodal tDCS Preceding Aphasia Therapy Terminated NCT02249819 Phase 1, Phase 2
48 Brain Stimulation and Aphasia Treatment Recruiting NCT01686373 Phase 2
49 Escitalopram and Language Intervention for Subacute Aphasia Not yet recruiting NCT03843463 Phase 2 Escitalopram 10mg;Placebo
50 Treating Intention In Aphasia: Neuroplastic Substrates Completed NCT00567242 Phase 1, Phase 2

Search NIH Clinical Center for Aphasia

Cochrane evidence based reviews: aphasia

Sources

Genetic Tests for Aphasia

About this section

Genetic tests related to Aphasia:

# Genetic test Affiliating Genes
1 Aphasia 30
Sources

Anatomical Context for Aphasia

About this section

MalaCards organs/tissues related to Aphasia:

42
Brain, Testes, Cortex, Eye, Temporal Lobe, Liver, Lung
Sources

Publications for Aphasia

About this section

Articles related to Aphasia:

(show top 50) (show all 3224)
# Title Authors Year
1
Adaption and validation of the Mississippi Aphasia Screening Test to Estonian speakers with aphasia. ( 30569561 )
2019
2
18F-flortaucipir uptake patterns in clinical subtypes of primary progressive aphasia. ( 30594046 )
2019
3
Genetic screen in a large series of patients with primary progressive aphasia. ( 30599136 )
2019
4
Semantic interference in speech error production in a randomized continuous naming task: Evidence from aphasia. ( 30619906 )
2019
5
The influence of β-amyloid on [18F]AV-1451 in semantic variant of primary progressive aphasia. ( 30635491 )
2019
6
Non-linguistic cognitive factors predict treatment-induced recovery in chronic post-stroke aphasia. ( 30639272 )
2019
7
Role of Cerebrospinal Fluid Biomarkers and (18)F-florbetapir PET Imaging in the Diagnosis of Primary Progressive Aphasia: A Retrospective Analysis. ( 30640253 )
2019
8
Bilingualism in Primary Progressive Aphasia: A Retrospective Study on Clinical and Language Characteristics. ( 30640254 )
2019
9
Primary Progressive Aphasia: Natural History in an Italian Cohort. ( 30640256 )
2019
10
Experiences of people with severe aphasia and spouses attending an Interdisciplinary Community Aphasia Group. ( 30652928 )
2019
11
Validated automatic speech biomarkers in primary progressive aphasia. ( 30656179 )
2019
12
Transcranial direct current stimulation in post-stroke aphasia rehabilitation: a systematic review. ( 30660671 )
2019
13
Repetitive verbal behaviors are not always harmful signs: Compensatory plasticity within the language network in aphasia. ( 30665003 )
2019
14
Cortical and structural-connectivity damage correlated with impaired syntactic processing in aphasia. ( 30666767 )
2019
15
Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates. ( 30668155 )
2019
16
Neuronavigated theta burst stimulation for chronic aphasia: two exploratory case studies. ( 30676091 )
2019
17
Recovery of Severe Aphasia After Cranioplasty: Considerations on a Case Study. ( 30681549 )
2019
18
Adjustment with aphasia after stroke: study protocol for a pilot feasibility randomised controlled trial for SUpporting wellbeing through PEeR Befriending (SUPERB). ( 30693094 )
2019
19
Primary progressive aphasia: a model for neurodegenerative disease. ( 30694922 )
2019
20
Progression of logopenic aphasia to frontotemporal dementia in an amyloid β-negative and 18 F-THK-5351-positive patient. ( 30712283 )
2019
21
Improvement in functional vocabulary and generalization to conversation following a self-administered treatment using a smart tablet in primary progressive aphasia. ( 30714482 )
2019
22
The contribution of semantic memory to the recognition of basic emotions and emotional valence: Evidence from the semantic variant of primary progressive aphasia. ( 30714843 )
2019
23
The "Artery of Aphasia," A Uniquely Sensitive Posterior Temporal Middle Cerebral Artery Branch that Supplies Language Areas in the Brain: Anatomy and Report of Four Cases. ( 30735868 )
2019
24
Findings of Impaired Hearing in Patients With Nonfluent/Agrammatic Variant Primary Progressive Aphasia. ( 30742208 )
2019
25
Morphology and Distribution of TDP-43 Pre-inclusions in Primary Progressive Aphasia. ( 30753613 )
2019
26
Counselling training for speech-language therapists working with people affected by post-stroke aphasia: a systematic review. ( 30758112 )
2019
27
Aphasia rehabilitation based on mirror neuron theory: a randomized-block-design study of neuropsychology and functional magnetic resonance imaging. ( 30762012 )
2019
28
TARDBP mutation associated with semantic variant primary progressive aphasia, case report and review of the literature. ( 30773994 )
2019
29
When Words Fail: Providing Effective Psychological Treatment for Depression in Persons with Aphasia. ( 30778804 )
2019
30
Humour in clinical-educational interactions between graduate student clinicians and people with aphasia. ( 30779411 )
2019
31
Emergence of artistic talent in progressive nonfluent aphasia: a case report. ( 30780199 )
2019
32
Performance validity measures in clinical patients with aphasia. ( 30794037 )
2019
33
Word form encoding is under attentional demand: evidence from dual-task interference in aphasia. ( 30811299 )
2019
34
A Case of Overlap Posterior Cortical Atrophy and Logopenic Variant Primary Progressive Aphasia. ( 30817493 )
2019
35
Speech Motor Planning in The Context of Phonetically Similar Words: Evidence from Apraxia of Speech and Aphasia. ( 30817912 )
2019
36
Cholinergic Neurons in Nucleus Subputaminalis in Primary Progressive Aphasia. ( 30819267 )
2019
37
Aphasia outcome: the interactions between initial severity, lesion size and location. ( 30820740 )
2019
38
Lexical retrieval treatment in primary progressive aphasia: An investigation of treatment duration in a heterogeneous case series. ( 30822613 )
2019
39
Risk Factors for Aphasia in Cerebral Small Vessel Diseases: A Retrospective Analysis. ( 30827240 )
2019
40
Depression and Subthreshold Depression in Stroke-Related Aphasia. ( 30831094 )
2019
41
Hereditary primary lateral sclerosis and progressive nonfluent aphasia. ( 30834979 )
2019
42
Variation in language mixing in multilingual aphasia. ( 30836773 )
2019
43
Cortical cholinergic denervation in primary progressive aphasia with Alzheimer pathology. ( 30842294 )
2019
44
Validity and features of spontaneous speech in acute aphasia as evaluated with the Brief Aphasia Evaluation: is fluent aphasia more severe than nonfluent aphasia? ( 30843923 )
2019
45
Divergent Patterns of TDP-43 and Tau Pathologies in Primary Progressive Aphasia. ( 30851133 )
2019
46
Use of co-verbal gestures during word-finding difficulty among Cantonese speakers with fluent aphasia and unimpaired controls. ( 30853744 )
2019
47
Continuous theta burst stimulation over right pars triangularis facilitates naming abilities in chronic post-stroke aphasia by enhancing phonological access. ( 30870740 )
2019
48
More than words: Social cognition across variants of primary progressive aphasia. ( 30876954 )
2019
49
Prominent auditory deficits in primary progressive aphasia: A case study. ( 30878181 )
2019
50
"The effect of tDCS on functional connectivity in primary progressive aphasia" NeuroImage: Clinical, volume 19 (2018), pages 703-715. ( 30878405 )
2019
Sources

Variations for Aphasia

About this section

ClinVar genetic disease variations for Aphasia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 46;XY;t(12;14)(q15;q13)mat Translocation Uncertain significance
Sources

Expression for Aphasia

About this section
Search GEO for disease gene expression data for Aphasia.
Sources

Pathways for Aphasia

About this section

Pathways related to Aphasia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
11.7 APOE APP GRIN2A L1CAM MAPT PRNP
2
Reelin Pathway (Cajal-Retzius cells) 65
11.55 APOE APP MAPT
3
G-protein signaling_Regulation of RAC1 activity 23
11.26 APOE APP MAPT
4
p75(NTR)-mediated signaling 1
Show member pathways
 11.25 APP BDNF PSEN1
5
Copper homeostasis 1
11.06 APP MAPT PRNP
6
Reelin signaling pathway 1
10.92 GRIN2A MAPT
7
Alzheimers Disease Pathway 65
10.91 APOE APP MAPT PSEN1
8
Glypican 1 network 1
10.85 APP PRNP
9
A-beta Pathways: Plaque Formation and APP Metabolism 66
10.68 APP PSEN1
Sources

GO Terms for Aphasia

About this section

Cellular components related to Aphasia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.85 APP GRIN2A L1CAM PRNP PSEN1 SRPX2
2 glutamatergic synapse GO:0098978 9.8 APOE CHMP2B CNKSR2 GRIN2A
3 neuronal cell body GO:0043025 9.8 APOE CNKSR2 L1CAM MAPT PSEN1
4 neuron projection GO:0043005 9.8 APP C9orf72 CNKSR2 GRIN2A MAPT PSEN1
5 postsynaptic density GO:0014069 9.76 CHMP2B CNKSR2 GRIN2A PRNP
6 membrane raft GO:0045121 9.73 APP MAPT PRNP PSEN1
7 axon GO:0030424 9.73 APP BDNF C9orf72 L1CAM MAPT PSEN1
8 growth cone GO:0030426 9.55 APP C9orf72 L1CAM MAPT PSEN1
9 smooth endoplasmic reticulum GO:0005790 9.54 APP PSEN1
10 synaptic membrane GO:0097060 9.52 GRIN2A SRPX2
11 axonal growth cone GO:0044295 9.51 C9orf72 L1CAM
12 ciliary rootlet GO:0035253 9.48 APP PSEN1
13 dendrite GO:0030425 9.17 APOE BDNF C9orf72 L1CAM MAPT PRNP
14 main axon GO:0044304 9.13 APP C9orf72 MAPT

Biological processes related to Aphasia according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 autophagy GO:0006914 9.84 C9orf72 CHMP2B PSEN1
2 negative regulation of neuron apoptotic process GO:0043524 9.82 APOE BDNF PSEN1
3 neuron projection development GO:0031175 9.81 APP L1CAM MAPT
4 response to oxidative stress GO:0006979 9.8 APOE APP PRNP PSEN1
5 memory GO:0007613 9.76 BDNF GRIN2A MAPT PSEN1
6 negative regulation of protein phosphorylation GO:0001933 9.75 C9orf72 PRNP PSEN1
7 forebrain development GO:0030900 9.73 APP FOXP2 PSEN1
8 learning or memory GO:0007611 9.73 APP GRIN2A PRNP PSEN1
9 regulation of synaptic plasticity GO:0048167 9.71 GRIN2A MAPT PSEN1
10 positive regulation of phosphorylation GO:0042327 9.67 APP PSEN1
11 cellular response to copper ion GO:0071280 9.67 APP PRNP
12 ionotropic glutamate receptor signaling pathway GO:0035235 9.66 APP GRIN2A
13 positive regulation of dendritic spine development GO:0060999 9.65 APOE PSEN1
14 regulation of protein binding GO:0043393 9.65 APP PSEN1
15 response to lead ion GO:0010288 9.64 APP MAPT
16 positive regulation of long-term synaptic potentiation GO:1900273 9.63 APP GRIN2A
17 regulation of peptidyl-tyrosine phosphorylation GO:0050730 9.63 APP PRNP
18 regulation of phosphorylation GO:0042325 9.62 PSEN1 SRPX2
19 axon development GO:0061564 9.62 L1CAM MAPT
20 stress granule assembly GO:0034063 9.61 C9orf72 MAPT
21 cellular copper ion homeostasis GO:0006878 9.61 APP PRNP
22 amyloid precursor protein metabolic process GO:0042982 9.6 APOE PSEN1
23 negative regulation of amyloid-beta formation GO:1902430 9.59 APOE PRNP
24 amyloid fibril formation GO:1990000 9.58 APP MAPT
25 astrocyte activation GO:0048143 9.58 APP MAPT PSEN1
26 locomotion GO:0040011 9.57 GRIN2A PSEN1
27 synapse organization GO:0050808 9.56 APP L1CAM MAPT PSEN1
28 negative regulation of low-density lipoprotein receptor activity GO:1905598 9.55 APP PSEN1
29 negative regulation of long-term synaptic potentiation GO:1900272 9.54 APOE APP PRNP
30 regulation of epidermal growth factor-activated receptor activity GO:0007176 9.52 APP PSEN1
31 astrocyte activation involved in immune response GO:0002265 9.51 APP PSEN1
32 neuron projection maintenance GO:1990535 9.5 APP PRNP PSEN1
33 smooth endoplasmic reticulum calcium ion homeostasis GO:0051563 9.48 APP PSEN1
34 modulation of age-related behavioral decline GO:0090647 9.33 APP PRNP PSEN1
35 cellular response to amyloid-beta GO:1904646 9.26 APP GRIN2A PRNP PSEN1
36 positive regulation of amyloid fibril formation GO:1905908 8.8 APOE APP PSEN1

Molecular functions related to Aphasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.17 APOE APP CNKSR2 FOXP2 MAPT PRNP
2 lipoprotein particle binding GO:0071813 8.96 APOE MAPT
3 protein binding GO:0005515 10 APOE APP C9orf72 CHMP2B CNKSR2 FOXP2
Sources

Sources for Aphasia

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....