Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Academic Licensing Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: APH001
MIFTS: 63

Aphthous Stomatitis

Categories: Rare diseases, Oral diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Aphthous Stomatitis

About this section

MalaCards integrated aliases for Aphthous Stomatitis:

Name: Aphthous Stomatitis 12 76 53 15 73
Oral Ulcer 12 29 55 73
Minor Oral Aphthous Ulceration 73
Stomatitis, Aphthous 44
Aphthous Ulceration 12
Oral Aphthous Ulcer 12
Oral Aphthae 12
Canker Sores 43
Canker Sore 12
Aphtha 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Oral diseases
See all MalaCards categories (disease lists)


Sources

Summaries for Aphthous Stomatitis

About this section
MedlinePlus : 43 Canker sores are small, round sores in your mouth. They can be on the inside of your cheek, under your tongue, or in the back of your throat. They usually have a red edge and a gray center. They can be quite painful. They are not the same as cold sores, which are caused by herpes simplex. Canker sores aren't contagious. They may happen if you have a viral infection. They may also be triggered by stress, food allergies, lack of vitamins and minerals, hormonal changes or menstrual periods. In some cases the cause is unknown. In most cases, the sores go away by themselves. Some ointments, creams or rinses may help with the pain. Avoiding hot, spicy food while you have a canker sore also helps.

MalaCards based summary : Aphthous Stomatitis, also known as oral ulcer, is related to cervical adenitis and pharyngitis, and has symptoms including halitosis, snoring and enanthema. An important gene associated with Aphthous Stomatitis is MEFV (MEFV, Pyrin Innate Immunity Regulator), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Infliximab and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include tongue, heart and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A stomatitis characterized by the repeated formation of benign and non-contagious mouth ulcers.

Wikipedia : 76 Aphthous stomatitis is a common condition characterized by the repeated formation of benign and... more...

Sources

Related Diseases for Aphthous Stomatitis

About this section

Diseases related to Aphthous Stomatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 323)
# Related Disease Score Top Affiliating Genes
1 cervical adenitis 31.6 IL1B MEFV NLRP3
2 pharyngitis 31.4 IL1B MEFV SPAG7
3 burns 31.0 IL1B TNF
4 glossitis 30.9 IL1B IL6
5 laryngitis 30.7 IL1B IL6 TNF
6 celiac disease 1 30.7 HLA-A IL10 TNF
7 periodic fever, familial, autosomal dominant 30.4 MEFV NLRP3 TNF
8 pyoderma gangrenosum 30.4 MEFV NLRP3 TNF
9 tonsillitis 30.3 IL1B IL4 IL6 TNF
10 helicobacter pylori infection 30.2 IL10 IL1B IL1RN TNF
11 gingivitis 30.1 IL1B IL4 IL6 TNF
12 pityriasis rosea 30.1 HLA-A HLA-B
13 periodontal disease 29.9 IL1B IL1RN IL6 TNF
14 intermediate uveitis 29.8 HLA-B IL10 IL6 TNF
15 burning mouth syndrome 29.8 IL6 MUC7 TNF
16 periodontitis 29.7 IL10 IL1B IL4 IL6 TNF
17 uveitis 29.6 HLA-B IL10 IL4 TNF
18 multiple sclerosis 29.4 IL10 IL1B IL4 IL6 TNF
19 arthritis 29.3 IL10 IL1B IL1RN IL6 TNF
20 rheumatic heart disease 29.1 HLA-A IL10 IL4 IL6 TNF
21 familial mediterranean fever 29.1 IL1B IL1RN MEFV NLRP3 TNF
22 brucellosis 28.9 IL10 IL1RN IL4 IL6 MEFV TNF
23 rheumatoid arthritis 27.8 HLA-B IL10 IL1B IL1RN IL4 IL6
24 behcet syndrome 26.9 HLA-A HLA-B IL10 IL1B IL1RN IL6
25 periodic fever, aphthous stomatitis, pharyngitis and adenitis 12.6
26 sutton disease 2 12.2
27 stomatitis 11.3
28 ulcerative stomatitis 11.2
29 scorpion envenomation 10.9 IL6 TNF
30 punctate inner choroidopathy 10.9 IL10 TNF
31 leukomalacia 10.9 IL6 TNF
32 angioimmunoblastic lymphadenopathy with dysproteinemia 10.9 IL6 TNF
33 staphylococcal toxic shock syndrome 10.8 IL1B TNF
34 critical limb ischemia 10.8 IL6 TNF
35 recurrent corneal erosion 10.8 IL1B IL6
36 streptococcal toxic-shock syndrome 10.8 IL6 TNF
37 autoimmune myocarditis 10.8 IL1B TNF
38 bagassosis 10.8 IL1B IL6
39 null-cell leukemia 10.8 IL6 TNF
40 kashin-beck disease 10.8 IL1B TNF
41 multifocal choroiditis 10.8 IL10 TNF
42 periodontitis, chronic 10.8 IL1B IL6
43 retinitis pigmentosa 55 10.8 IL6 TNF
44 transient hypogammaglobulinemia 10.8 IL10 TNF
45 eye lymphoma 10.8 IL10 IL6
46 autoinflammation, panniculitis, and dermatosis syndrome 10.8 MEFV TNF
47 anca-associated vasculitis 10.8 IL6 TNF
48 acute transverse myelitis 10.8 IL10 IL6
49 choroiditis 10.7 IL10 TNF
50 uremic pruritus 10.7 IL1B IL6

Graphical network of the top 20 diseases related to Aphthous Stomatitis:



Diseases related to Aphthous Stomatitis
Sources

Symptoms & Phenotypes for Aphthous Stomatitis

About this section

UMLS symptoms related to Aphthous Stomatitis:


halitosis, snoring, enanthema, oral manifestations, oral mucosal blisters, sore mouth

GenomeRNAi Phenotypes related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.75 HLA-A HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.75 HLA-B HLA-A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.75 HLA-B HLA-A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.75 HLA-B HLA-A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.75 HLA-A HLA-B
6 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.75 MUC7
7 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.75 MUC7
8 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.75 HLA-A HLA-B
9 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.75 MUC7
10 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.75 MUC7
11 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.75 MUC7
12 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.75 MUC7
13 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.75 MUC7
14 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.75 MUC7
15 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.75 HLA-A HLA-B MUC7
16 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.75 HLA-A HLA-B
17 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.75 HLA-A HLA-B

MGI Mouse Phenotypes related to Aphthous Stomatitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 MEFV IL10 IL1B NLRP3 IL1RN TNF
2 immune system MP:0005387 9.92 MEFV IL10 IL1B NLRP3 IL1RN TNF
3 integument MP:0010771 9.86 NLRP3 IL1B IL1RN TNF IL4 IL6
4 liver/biliary system MP:0005370 9.63 NLRP3 TNF IL4 IL6 MEFV IL10
5 reproductive system MP:0005389 9.5 IL10 NLRP3 IL1RN TNF IL4 IL6
6 skeleton MP:0005390 9.23 NLRP3 IL1B IL1RN TNF IL4 IL6
Sources

Drugs & Therapeutics for Aphthous Stomatitis

About this section

Drugs for Aphthous Stomatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 138)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4 170277-31-3
2 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
3 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Phase 1
4 Dermatologic Agents Phase 4,Phase 2,Early Phase 1
5
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
6
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Early Phase 1 50-02-2 5743
7
Menthol Approved Phase 3,Phase 2 2216-51-5 16666
8
Procaine Approved, Investigational, Vet_approved Phase 3 59-46-1 4914
9
Glycerol Approved, Investigational Phase 3 56-81-5 753
10
Hydroxocobalamin Approved Phase 3,Not Applicable 13422-51-0 11953898 44475014
11
Miconazole Approved, Investigational, Vet_approved Phase 3,Not Applicable 22916-47-8 4189
12
Everolimus Approved Phase 3,Not Applicable 159351-69-6 6442177
13
Adalimumab Approved Phase 2, Phase 3,Phase 3 331731-18-1 16219006
14
Azathioprine Approved Phase 3 446-86-6 2265
15
Ethanol Approved Phase 3 64-17-5 702
16
Neomycin Approved, Vet_approved Phase 3 1404-04-2 8378
17
Sirolimus Approved, Investigational Phase 3,Not Applicable 53123-88-9 5284616 6436030 46835353
18
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
19
Tacrolimus Approved, Investigational Phase 3 104987-11-3 445643 439492
20
Mycophenolic acid Approved Phase 3 24280-93-1 446541
21
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
22
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 11103-57-4, 68-26-8 445354
23
Cyanocobalamin Approved, Nutraceutical Phase 3,Not Applicable 68-19-9 44176380
24 Dexamethasone acetate Phase 3,Early Phase 1 1177-87-3
25 glucocorticoids Phase 3,Phase 2
26
protease inhibitors Phase 3
27 HIV Protease Inhibitors Phase 3
28 Hormone Antagonists Phase 3,Phase 2
29 Hormones Phase 3,Phase 2
30 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
31 Peripheral Nervous System Agents Phase 3,Phase 2,Early Phase 1
32 Anti-Bacterial Agents Phase 3,Phase 2,Not Applicable
33 Anti-Infective Agents Phase 3,Phase 2,Not Applicable
34 Antiemetics Phase 3,Phase 2,Early Phase 1
35 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1
36 BB 1101 Phase 3,Early Phase 1
37 Autonomic Agents Phase 3,Phase 2,Early Phase 1
38 Antineoplastic Agents, Hormonal Phase 3,Phase 2
39
Bismuth Phase 3 7440-69-9 16682734 105143
40 Central Nervous System Depressants Phase 3,Phase 2,Early Phase 1
41 Retinol palmitate Phase 3
42 Micronutrients Phase 3,Phase 2,Not Applicable
43 Anesthetics Phase 3,Phase 2,Early Phase 1
44 N-Methylaspartate Phase 3
45 Trace Elements Phase 3,Phase 2,Not Applicable
46 Anesthetics, Local Phase 3,Phase 2,Early Phase 1
47 Antacids Phase 3
48 Vitamin B 12 Phase 3,Not Applicable
49 Antibiotics, Antitubercular Phase 3,Not Applicable
50 Vitamins Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 52)
# Name Status NCT ID Phase Drugs
1 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4 infliximab;placebo
2 The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus Unknown status NCT01083420 Phase 3 Minocycline;Dexamethasone
3 Prevention of Recurrent Aphthous Stomatitis Using Vitamins Completed NCT00527306 Phase 3
4 Efficacy of the Combination Bismuth + Neomycin + Procaine in the Treatment of Recurrent Aphthous Ulceration Completed NCT00857688 Phase 3 Bismu-Jet
5 A Study of Adalimumab for the Maintenance of Clinical Remission in Japanese Subjects With Crohn's Disease Completed NCT00445432 Phase 2, Phase 3
6 Efficacy and Safety of Two Treatment Algorithms in Adults With Moderate to Severe Crohn's Disease Completed NCT01235689 Phase 3 Prednisone;Azathioprine
7 Tacrolimus/Everolimus vs. Tacrolimus/MMF in Pediatric Heart Transplant Recipients Using the MATE Score Recruiting NCT03386539 Phase 3 Everolimus;Tacrolimus;Mycophenolate Mofetil
8 Omega-3 and Quality of Life in Recurrent Aphthous Stomatitis Patients Unknown status NCT01831453 Phase 2 omega-3;placebo
9 Evaluation of Therapeutic Effect of 0.5 mg Colchicine and 5 mg Prednisolone on Oral Aphthae Unknown status NCT00723268 Phase 2 Prednisolone;Colchicine
10 Systemic Zinc Sulphate in Treatment of Recurrent Aphthous Ulcerations:A Doubleblind, Placebo Controled Study Completed NCT01210014 Phase 2 zinc sulphate 220mg/day in one dosage;placebo: one dosage
11 Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis Completed NCT01293968 Phase 2 Ibuprofen, Diphenhydramine and Aluminium MgS;Diphenhydramine and Aluminium MgS
12 Efficacy and Safety Study of Yunnan Baiyao on Minor Recurrent Aphthous Stomatitis Completed NCT01652625 Phase 2 Yunnan Baiyao toothpaste;Placebo toothpaste
13 Thalidomide for Treatment of Oral and Esophageal Aphthous Ulcers and HIV Viremia in Patients With HIV Infection Completed NCT00000790 Phase 2 Thalidomide
14 Topical "Non-Aromatic Very Rich in Steranes" (NAVS) Naphthalan for the Treatment of Oral Mucosal Diseases Completed NCT02920658 Phase 2 NAVS Naphthalan;0.05% Betamethasone dipropionate
15 Colchicine Randomized Double-Blind Controlled Crossover Study in Behcet's Disease Completed NCT00700297 Phase 2 Colchicine;Placebo
16 PillCam® Platform With the PillCam Crohn's Disease Capsule Completed NCT01631435 Phase 1, Phase 2
17 Anakinra for Behcet s Disease Completed NCT01441076 Phase 1, Phase 2 Anakinra
18 Thalidomide to Treat Oral Lesions in HIV-Infected Patients Completed NCT00001524 Phase 2 Thalidomide
19 Effectiveness and Safety of Lactobacillus Rhamnosus Lcr35® in the Treatment of Recurrent Aphthous Stomatitis Recruiting NCT02789605 Phase 2 Bacilor;Placebo
20 Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome Recruiting NCT03469232 Phase 1, Phase 2 Huanglian-Jiedu Decoction
21 Vedolizumab Post Op Study Not yet recruiting NCT02834754 Phase 2 Vedolizumab;placebo
22 Efficacy of Adhesive Tablets in Treating Oral Ulcers (Aphthous) Suspended NCT00281723 Phase 2 Pro-Pe adhesive tablet
23 Efficacy, Safety and Tolerability of AIN457 in Moderate to Severe Active Crohn's Disease Terminated NCT00584740 Phase 2 AIN457;Placebo
24 Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of ITF2357 on Mucosal Healing in Patients With Moderate-to-severe Active Crohn's Disease Terminated NCT00792740 Phase 1, Phase 2 ITF2357;Placebo capsules
25 Effectiveness of Topical Thalidomide to Treat Chronic Graft-Versus-Host-Disease Related Stomatitis Terminated NCT00075023 Phase 2 Thalidomide Gel;Placebo Gel
26 Probiotics and Corticosteroids for Treating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) Withdrawn NCT02535962 Phase 2
27 Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Unknown status NCT02775994 Phase 1 Canakinumab
28 Clinical Evaluation of Fluid Extract of Chamomilla Tincture for Oral Aphthae Completed NCT01122147 Phase 1 chamomilla tincture mouthwash;placebo mouthwash
29 Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis Completed NCT01501409 Not Applicable
30 Oral Vitamin B12 as Potential Treatment of Recurrent Aphthous Stomatitis Completed NCT00288769 Not Applicable daily sublingual tablets Vitamin B12 1000 mcg versus placebo
31 Treatment of Recurrent Aphthous Stomatitis With Er,Cr:YSGG Laser Irradiation Completed NCT02925182 Not Applicable
32 The Effect of 2-DeNT Oral Topical Powder on Minor Recurrent Aphthous Ulcer Completed NCT02142543 Early Phase 1 2-DeNT powder;Placebo Comparator
33 A Trial of Pentoxifylline for the Treatment of Recurrent Aphthous Stomatitis Completed NCT00315679 Not Applicable Pentoxifylline (also known as oxpentifylline)
34 Abdominal Ultrasound Examination in Non-celiac Wheat Sensitivity Completed NCT03017274
35 Evaluation and Treatment of Oral Soft Tissue Diseases Completed NCT00001601 Not Applicable
36 Special Investigation in Patients With Intestinal Behcet's Disease (All Case Investigation) Completed NCT01960790
37 The Vienna RAP Pilot Study Completed NCT01632605 Not Applicable Sirolimus
38 Tokushima Night Guard for Recurrent Aphthous Stomatitis Recruiting NCT02890524 Early Phase 1
39 The Salivary and Faecal Microbiome of Recurrent Aphthous Stomatitis Patients Before and After Treatment With Probiotics Recruiting NCT02976922 Not Applicable
40 Tonsillotomy or Follow-up in PFAPA Syndrome Recruiting NCT03331497 Not Applicable
41 Gynaecological Disorders in Not-celiac Wheat Sensitivity Recruiting NCT03027492 Not Applicable
42 Lactose Intolerance and Cow's Milk Protein Allergy in Non-celiac Wheat Sensitivity Patients Recruiting NCT03008252
43 Fibromyalgia-like Joint/Muscle Pain and Synovitis in Non-celiac Wheat Sensitivity Patients Recruiting NCT03022513 Not Applicable
44 Salivary Cytokines as Biomarker for Oral Health Recruiting NCT02807519
45 Oral Lesions In Non-Celiac Wheat Sensitivity Patients Recruiting NCT02421809
46 Entyvio (Vedolizumab) Long Term Safety Study Recruiting NCT02674308 Vedolizumab
47 Identification of Viruses Associated With Diseases of Unknown Cause Enrolling by invitation NCT00359268
48 Clinical Evaluation of Topical Coenzyme Q10 in Management of Oral Aphthous Ulcer Not yet recruiting NCT03213769 Not Applicable topical coenzyme Q10 gel;Carpabol gel
49 The Clinical and Biological Effects Of The Use Of Probiotic VSL#3 In Patients With Oral Lichen Planus Not yet recruiting NCT03052179 Not Applicable
50 Influence of Different Doses of the Vitamin B12 on Recurrent Aphthous Stomatitis Terminated NCT01127724 Not Applicable vitamin B12 treatment

Search NIH Clinical Center for Aphthous Stomatitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: stomatitis, aphthous

Sources

Genetic Tests for Aphthous Stomatitis

About this section

Genetic tests related to Aphthous Stomatitis:

# Genetic test Affiliating Genes
1 Oral Ulcer 29
Sources

Anatomical Context for Aphthous Stomatitis

About this section

MalaCards organs/tissues related to Aphthous Stomatitis:

41
Tongue, Heart, Testes, Neutrophil, Liver, T Cells, Tonsil
Sources

Publications for Aphthous Stomatitis

About this section

Articles related to Aphthous Stomatitis:

(show top 50) (show all 640)
# Title Authors Year
1
Association of Serotonin Transporter Gene Polymorphism with Recurrent Aphthous Stomatitis. ( 29296268 )
2018
2
Tonsillar antimicrobial peptide (AMP) expression profiles of periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) patients. ( 29859567 )
2018
3
Prevalence and psychological stress in recurrent aphthous stomatitis among female dental students in Saudi Arabia. ( 29785161 )
2018
4
The association between minor recurrent aphthous stomatitis (RAS), children's poor oral condition, and underlying negativeA psychosocial habits and attitudes towards oral hygiene. ( 29653566 )
2018
5
Comorbidity of PFAPA (periodic fever, aphthous stomatitis, pharyngitis and adenitis) patients: a case control study. ( 29533751 )
2018
6
Gastric parietal cell and thyroid autoantibodies in recurrent aphthous stomatitis patients with concomitant oral lichen planus. ( 29753458 )
2018
7
Autosomal dominant deficiency of the interleukin-17F in recurrent aphthous stomatitis: Possible novel mutation in a new entity. ( 29458167 )
2018
8
Associations of IL-1, 6, and 10 Gene Polymorphisms with Susceptibility to Recurrent Aphthous Stomatitis: Insights from a Meta-Analysis. ( 29641282 )
2018
9
Risk factors for periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: a case-control study. ( 29799086 )
2018
10
Association between interleukin family gene polymorphisms and recurrent aphthous stomatitis risk. ( 29550839 )
2018
11
Association of the nod-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population. ( 29430721 )
2018
12
The First International Conference on Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis Syndrome. ( 29246466 )
2018
13
Healthy lifestyle habits benefit remission of recurrent aphthous stomatitis and RAS type ulceration. ( 29327722 )
2018
14
Pregnancy complicated with PFAPA (periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis) syndrome: a case report. ( 29866074 )
2018
15
The role of tonsillectomy in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome; a literature review. ( 29483843 )
2018
16
Hematinic dei-8ciencies in patients with recurrent aphthous stomatitis: variations by gender and age. ( 29476670 )
2018
17
Salivary levels of TNF-I+ in patients with recurrent aphthous stomatitis: A cross-sectional study. ( 29732020 )
2018
18
Relationship between salivary calprotectin levels and recurrent aphthous stomatitis: A preliminary study. ( 29519972 )
2018
19
Examination of serum hematinics and autoantibodies is important for treatment of recurrent aphthous stomatitis. ( 29336939 )
2018
20
Analysis of Dietary Related Factors of Recurrent Aphthous Stomatitis among College Students. ( 29681971 )
2018
21
Haematinic deficiencies and patient clinical profiles in Polish patients with recurrent aphthous stomatitis (RAS). ( 29499093 )
2018
22
The association between interleukin polymorphism and recurrent aphthous stomatitis: A meta-analysis. ( 29800802 )
2018
23
Evidence that Enterobius vermicularis plays a causative role for PFAPA and recurrent aphthous stomatitis. ( 29856193 )
2018
24
Evaluation and Comparison of Total Antioxidant Capacity of Saliva Between Patients with Recurrent Aphthous Stomatitis and Healthy Subjects. ( 29755602 )
2018
25
Chitosan/pvp-based mucoadhesive membranes as a promising delivery system of betamethasone-17-valerate for aphthous stomatitis. ( 29628256 )
2018
26
Enamel defects and aphthous stomatitis in celiac and healthy subjects: Systematic review and meta-analysis of controlled studies. ( 28688949 )
2017
27
A Clinical and Microbiological Evaluation of Helicobacter pylori in Recurrent Aphthous Stomatitis. ( 29208798 )
2017
28
Preventive effects of mouthguard use while sleeping on recurrent aphthous stomatitis: Preliminary interventional study. ( 29744201 )
2017
29
Evaluation of serum zinc levels in patients with recurrent aphthous stomatitis (RAS). ( 29262804 )
2017
30
INTERMEDIATE UVEITIS ASSOCIATED WITH PERIODIC FEVER, APHTHOUS STOMATITIS, PHARYNGITIS, AND CERVICAL ADENITIS SYNDROME. ( 28570435 )
2017
31
Interleukin-2, Interferon-gamma Gene Polymorphisms in Recurrent Aphthous Stomatitis. ( 28922104 )
2017
32
Letter regarding "Effect of laser on pain relief and wound healing of recurrent aphthous stomatitis: a systematic review". ( 28801870 )
2017
33
Periodic Fever with Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome Is Associated with a CARD8 Variant Unable To Bind the NLRP3 Inflammasome. ( 28137891 )
2017
34
Antigastric parietal cell and antithyroid autoantibodies in patients with recurrent aphthous stomatitis. ( 27793414 )
2017
35
Immune response of patients with recurrent aphthous stomatitis challenged with a symbiotic. ( 28776757 )
2017
36
Recurrent aphthous stomatitis in 18-year-old adolescents - Prevalence and associated factors: a population-based study. ( 29166496 )
2017
37
Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (pfapa) syndrome in children. ( 28343210 )
2017
38
Diagnostic Criteria for Adult-Onset Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome. ( 28970828 )
2017
39
A case of adult-onset periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome in Japan. ( 29264037 )
2017
40
Association of IL-6-174a88G/C and IL10-1082a88G/A polymorphisms with recurrent aphthous stomatitis risk: A meta-analysis. ( 29384969 )
2017
41
Apremilast for treatment of recalcitrant aphthous stomatitis. ( 28884141 )
2017
42
Unraveling the pathogenesis of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis through genetic, immunologic, and microbiologic discoveries: an update. ( 28557837 )
2017
43
Aphthous Stomatitis ( 28613713 )
2017
44
The efficacy of minocycline mouth rinses on the symptoms associated with recurrent aphthous stomatitis: a randomized, double-blind, crossover study assessing different doses of oralA rinse. ( 28411006 )
2017
45
Unique histologic features of tonsils from patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 28748511 )
2017
46
Evaluation of Salivary Cortisol Changes and Psychological Profiles in Patients with Recurrent Aphthous Stomatitis. ( 28839413 )
2017
47
The absence of an association between Interleukin 1I^ gene polymorphisms and recurrent aphthous stomatitis (RAS). ( 28942153 )
2017
48
Systemic bioinformatics analysis of recurrent aphthous stomatitis gene expression profiles. ( 29340037 )
2017
49
Vitamin D status in recurrent aphthous stomatitis. ( 29422828 )
2017
50
Physicians' perspectives on the diagnosis and management of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 28271158 )
2017
Sources

Variations for Aphthous Stomatitis

About this section
Sources

Expression for Aphthous Stomatitis

About this section
Search GEO for disease gene expression data for Aphthous Stomatitis.
Sources

Pathways for Aphthous Stomatitis

About this section

Pathways related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.87 HLA-A HLA-B IL10 IL1B IL1RN IL4
2
Cytokine Signaling in Immune system 66
Show member pathways
 13.27 HLA-A HLA-B IL10 IL1B IL1RN IL4
3
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.96 IL10 IL1B IL6 MEFV NLRP3 TNF
4
PI3K-Akt signaling pathway 37
Show member pathways
 12.91 HLA-A HLA-B IL4 IL6 TNF
5
Allograft rejection 1 37
Show member pathways
 12.76 HLA-A HLA-B IL10 IL1B IL4 IL6
6
Influenza A 37
Show member pathways
 12.55 HLA-A HLA-B IL1B IL4 IL6 NLRP3
7
NF-kappaB Signaling 4
12.54 IL10 IL1B IL1RN IL4 TNF
8
Immune response IL-23 signaling pathway 22
Show member pathways
 12.53 IL10 IL1B IL6 TNF
9
Kaposi's sarcoma-associated herpesvirus infection 37
Show member pathways
 12.51 HLA-A HLA-B IL6 TNF
10
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.46 HLA-A HLA-B IL4 TNF
11
Th17 cell differentiation 37
Show member pathways
 12.41 IL10 IL1B IL4 IL6 TNF
12
HTLV-I infection 37
12.39 HLA-A HLA-B IL6 TNF
13
T cell receptor signaling pathway 37
Show member pathways
 12.39 IL10 IL1B IL4 IL6 TNF
14
Folate Metabolism 1
Show member pathways
 12.31 IL1B IL4 IL6 TNF
15
IL-17 Family Signaling Pathways 65
Show member pathways
 12.3 IL1B IL4 IL6 TNF
16
Regulation of IFNA signaling 66
Show member pathways
 12.3 HLA-A HLA-B IL10 IL1B IL4 IL6
17
Th1 Differentiation Pathway 65
Show member pathways
 12.24 IL10 IL1B IL6 TNF
18
Toxoplasmosis 37
Show member pathways
 12.23 IL10 IL1B IL4 TNF
19
Tuberculosis 37
12.2 IL10 IL1B IL6 TNF
20
Toll Comparative Pathway 64
Show member pathways
 12.19 IL1B IL6 TNF
21
IL-1 Family Signaling Pathways 65
Show member pathways
 12.19 IL1B IL1RN IL6 TNF
22
Bacterial infections in CF airways 22
Show member pathways
 12.16 IL1B IL4 IL6 TNF
23
C-type lectin receptor signaling pathway 37
Show member pathways
 12.16 IL10 IL1B IL6 NLRP3 TNF
24
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.12 IL10 IL1B IL1RN IL6 TNF
25
Cellular senescence (KEGG) 37
12.09 HLA-A HLA-B IL6
26
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.02 IL10 IL1B IL4 IL6
27
Spinal Cord Injury 1
12 IL1B IL4 IL6 TNF
28
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.98 IL10 IL4 IL6 TNF
29
IL12-mediated signaling events 1
Show member pathways
 11.93 HLA-A IL1B IL4
30
TNF signaling pathway 37
11.91 IL1B IL6 TNF
31
Hematopoietic cell lineage 37
11.89 IL1B IL4 IL6 TNF
32
Amoebiasis 37
11.88 IL10 IL1B IL6 TNF
33
AGE-RAGE signaling pathway in diabetic complications 37
11.86 IL1B IL6 TNF
34
Interleukin-4 and 13 signaling 66
11.86 IL10 IL1B IL4 IL6 TNF
35
Rheumatoid arthritis 37
11.82 IL1B IL6 TNF
36
Innate Lymphoid Cell Differentiation Pathways 65
11.78 IL10 IL1B IL4 TNF
37
Dendritic Cells Developmental Lineage Pathway 65
11.74 IL10 IL1B IL6 TNF
38
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.65 IL1B IL6 TNF
39
Lung fibrosis 1
11.65 IL1B IL4 IL6 TNF
40
Legionellosis 37
11.58 IL1B IL6 TNF
41
Pertussis 37
11.54 IL10 IL1B IL6 NLRP3 TNF
42
Malaria 37
11.49 IL10 IL1B IL6 TNF
43
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.48 IL1B IL6 TNF
44
Nucleotide-binding Oligomerization Domain (NOD) pathway 1
11.43 IL1B MEFV NLRP3
45
Antifolate resistance 37
11.3 IL1B IL6 TNF
46
African trypanosomiasis 37
11.3 IL10 IL1B IL6 TNF
47
IL-10 Pathway 64
11.28 IL10 IL1B IL6 TNF
48
Development and heterogeneity of the ILC family 1
11.17 IL1B IL4 IL6 TNF
49
Antigen Presentation- Folding, assembly and peptide loading of class I MHC 66
11.12 HLA-A HLA-B
50
IL1 and megakaryocytes in obesity 1
11.11 IL1B NLRP3
Sources

GO Terms for Aphthous Stomatitis

About this section

Cellular components related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.23 IL10 IL1B IL1RN IL4 IL6 MUC7
2 MHC class I protein complex GO:0042612 8.96 HLA-A HLA-B

Biological processes related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of inflammatory response GO:0050728 9.85 IL10 MEFV NLRP3
2 regulation of signaling receptor activity GO:0010469 9.85 IL10 IL1B IL1RN IL4 IL6 TNF
3 defense response to Gram-positive bacterium GO:0050830 9.84 IL6 NLRP3 TNF
4 positive regulation of T cell proliferation GO:0042102 9.77 IL1B IL4 IL6
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.76 IL1B IL6 NLRP3 TNF
6 positive regulation of interleukin-6 production GO:0032755 9.73 IL1B IL6 TNF
7 cellular response to lipopolysaccharide GO:0071222 9.73 IL10 IL6 NLRP3 TNF
8 positive regulation of DNA binding transcription factor activity GO:0051091 9.71 IL10 IL1B IL6 TNF
9 positive regulation of chemokine production GO:0032722 9.68 IL6 TNF
10 negative regulation of lipid catabolic process GO:0050995 9.68 IL1B TNF
11 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.68 IL1B TNF
12 negative regulation of growth of symbiont in host GO:0044130 9.68 IL10 TNF
13 negative regulation of interleukin-12 production GO:0032695 9.67 IL10 MEFV
14 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.66 IL10 IL1RN
15 negative regulation of lipid storage GO:0010888 9.66 IL6 TNF
16 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.65 HLA-A HLA-B
17 positive regulation of interleukin-13 production GO:0032736 9.65 IL4 NLRP3
18 positive regulation of chemokine biosynthetic process GO:0045080 9.65 IL1B TNF
19 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.65 IL1B NLRP3 TNF
20 endothelial cell apoptotic process GO:0072577 9.64 IL10 TNF
21 positive regulation of MHC class II biosynthetic process GO:0045348 9.63 IL10 IL4
22 regulation of establishment of endothelial barrier GO:1903140 9.63 IL1B TNF
23 cytokine-mediated signaling pathway GO:0019221 9.63 IL10 IL1B IL1RN IL4 IL6 TNF
24 negative regulation of cytokine secretion involved in immune response GO:0002740 9.62 IL10 TNF
25 type 2 immune response GO:0042092 9.61 IL10 IL4
26 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.61 IL6 NLRP3
27 positive regulation of fever generation GO:0031622 9.59 IL1B TNF
28 fever generation GO:0001660 9.58 IL1B IL1RN
29 protection from natural killer cell mediated cytotoxicity GO:0042270 9.58 HLA-A HLA-B
30 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.57 IL1RN IL6
31 response to glucocorticoid GO:0051384 9.56 IL10 IL1RN IL6 TNF
32 interleukin-1 beta production GO:0032611 9.55 IL1B NLRP3
33 regulation of isotype switching GO:0045191 9.54 IL10 IL4
34 sequestering of triglyceride GO:0030730 9.52 IL1B TNF
35 receptor biosynthetic process GO:0032800 9.51 IL10 TNF
36 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.5 IL10 IL1B TNF
37 inflammatory response GO:0006954 9.5 IL10 IL1B IL1RN IL6 MEFV NLRP3
38 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 IL1B TNF
39 immune response GO:0006955 9.23 HLA-A HLA-B IL10 IL1B IL1RN IL4
40 positive regulation of transcription by RNA polymerase II GO:0045944 10.1 IL10 IL1B IL4 IL6 NLRP3 TNF
41 positive regulation of transcription, DNA-templated GO:0045893 10.04 IL10 IL1B IL4 IL6 TNF

Molecular functions related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 IL10 IL4 IL6
2 cytokine activity GO:0005125 9.1 IL10 IL1B IL1RN IL4 IL6 TNF
3 interleukin-1 receptor binding GO:0005149 8.96 IL1B IL1RN
Sources

Sources for Aphthous Stomatitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....