Aphthous Stomatitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: APH001 MIFTS: 64	Aphthous Stomatitis Categories: Oral diseases, Rare diseases
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Aliases & Classifications for Aphthous Stomatitis

MalaCards integrated aliases for Aphthous Stomatitis:

Name: Aphthous Stomatitis ¹² ⁷⁶ ⁵³ ¹⁵ ⁷³

Oral Ulcer ¹² ²⁹ ⁵⁵ ⁷³

Minor Oral Aphthous Ulceration ⁷³

Stomatitis, Aphthous ⁴⁴

Aphthous Ulceration ¹²

Oral Aphthous Ulcer ¹²

Oral Aphthae ¹²

Canker Sores ⁴³

Canker Sore ¹²

Aphtha ¹²

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Oral diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:9663

ICD9CM ³⁵ 528.2

MeSH ⁴⁴ D013281

NCIt ⁵⁰ C62546

SNOMED-CT ⁶⁸ 83312008

UMLS ⁷³ C0038363 C0585213 C0149745

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Summaries for Aphthous Stomatitis

MedlinePlus : ⁴³ Canker sores are small, round sores in your mouth. They can be on the inside of your cheek, under your tongue, or in the back of your throat. They usually have a red edge and a gray center. They can be quite painful. They are not the same as cold sores, which are caused by herpes simplex. Canker sores aren't contagious. They may happen if you have a viral infection. They may also be triggered by stress, food allergies, lack of vitamins and minerals, hormonal changes or menstrual periods. In some cases the cause is unknown. In most cases, the sores go away by themselves. Some ointments, creams or rinses may help with the pain. Avoiding hot, spicy food while you have a canker sore also helps.

MalaCards based summary : Aphthous Stomatitis, also known as oral ulcer, is related to stomatitis and mouth disease, and has symptoms including enanthema, oral mucosal blisters and snoring. An important gene associated with Aphthous Stomatitis is MEFV (MEFV, Pyrin Innate Immunity Regulator), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Infliximab and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include tongue, bone and heart, and related phenotypes are growth/size/body region and cellular

Disease Ontology : ¹² A stomatitis characterized by the repeated formation of benign and non-contagious mouth ulcers.

Wikipedia : ⁷⁶ Aphthous stomatitis is a common condition characterized by the repeated formation of benign and... more...

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Related Diseases for Aphthous Stomatitis

Diseases related to Aphthous Stomatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 438)

#	Related Disease	Score	Top Affiliating Genes
1	stomatitis	32.4	IL1B MEFV TNF
2	mouth disease	31.9	IL10 IL1B IL6 TNF
3	orofacial granulomatosis	31.7	IL10 IL4 TNF
4	pharyngitis	31.7	IL1B MEFV SPAG7
5	cervical adenitis	31.4	IL1B MEFV NLRP3
6	celiac disease 1	30.3	HLA-A IL10 IL2 TNF
7	diversion colitis	30.3	IL1B IL4
8	pyoderma gangrenosum	30.2	MEFV NLRP3 TNF
9	glossitis	30.2	IL1B IL6 TNF
10	laryngitis	30.2	IL1B IL6 TNF
11	familial mediterranean fever	30.2	IL1B IL1RN MEFV NLRP3 TNF
12	chikungunya	30.2	IL1B IL6 TNF
13	pityriasis rosea	30.1	HLA-A HLA-B
14	periodic fever, familial, autosomal dominant	30.0	MEFV NLRP3 TNF
15	uveitis	30.0	HLA-B IL10 IL4 TNF
16	arthritis	29.9	IL10 IL1B IL1RN IL6 TNF
17	gingivitis	29.8	IL1B IL4 IL6 TLR2 TNF
18	rheumatic heart disease	29.8	HLA-B IL10 IL4 IL6 TNF
19	chronic graft versus host disease	29.8	IL10 TNF
20	burning mouth syndrome	29.8	IL2 IL6 TNF
21	periodontal disease	29.8	IL1B IL1RN IL6 TLR2 TNF
22	neurosyphilis	29.6	IL10 TLR2
23	crohn's colitis	29.6	IL1B IL2 TNF
24	intermediate uveitis	29.5	HLA-B IL10 IL2 IL6 TNF
25	colitis	29.5	IL10 IL1B IL2 IL4 IL6 TNF
26	viral infectious disease	29.5	IL10 IL1B IL2 IL4 IL6 TNF
27	human immunodeficiency virus infectious disease	29.5	IL10 IL2 IL6 TNF
28	multiple sclerosis	29.4	IL10 IL1B IL2 IL4 IL6 TNF
29	pulmonary tuberculosis	29.4	IL10 IL2 IL4 TLR2 TNF
30	severe cutaneous adverse reaction	29.3	HLA-A HLA-B TNF
31	periodontitis	29.2	IL10 IL1B IL4 IL6 TLR2 TNF
32	human herpesvirus 8	29.1	HLA-A HLA-B IL6
33	visceral leishmaniasis	28.8	IL10 IL2 IL4 TLR2 TNF
34	acquired immunodeficiency syndrome	28.7	HLA-B IL10 IL1B IL2 IL6 TNF
35	rheumatoid arthritis	28.7	HLA-B IL10 IL1B IL1RN IL2 IL4
36	inflammatory bowel disease	28.7	HLA-B IL10 IL1B IL1RN IL2 IL4
37	behcet syndrome	28.6	HLA-A HLA-B IL10 IL1B IL1RN IL2
38	leishmaniasis	28.5	IL10 IL1B IL2 IL4 IL6 TLR2
39	systemic lupus erythematosus	28.4	IL10 IL1B IL2 IL4 IL6 TLR2
40	graft-versus-host disease	28.4	HLA-A HLA-B IL10 IL1B IL2 IL6
41	periodic fever, aphthous stomatitis, pharyngitis and adenitis	12.8
42	sutton disease 2	12.4
43	ulcerative stomatitis	11.3
44	immunodeficiency 12	11.2
45	acatalasemia	11.0
46	chronic active epstein-barr virus infection	11.0
47	anxiety	10.5
48	lichen planus	10.4
49	oral lichen planus	10.4
50	recurrent corneal erosion	10.3	IL1B IL6

Graphical network of the top 20 diseases related to Aphthous Stomatitis:

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Symptoms & Phenotypes for Aphthous Stomatitis

UMLS symptoms related to Aphthous Stomatitis:

enanthema, oral mucosal blisters, snoring, halitosis, oral manifestations, sore mouth

MGI Mouse Phenotypes related to Aphthous Stomatitis:

⁴⁶ (show all 13)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.19	IL10 IL1B IL1RN IL2 IL4 IL6
2	cellular	MP:0005384	10.18	IL10 IL1RN IL2 IL4 IL6 MEFV
3	hematopoietic system	MP:0005397	10.18	IL10 IL1B IL1RN IL2 IL4 IL6
4	homeostasis/metabolism	MP:0005376	10.16	IL10 IL1B IL1RN IL2 IL4 IL6
5	immune system	MP:0005387	10.13	IL10 IL1B IL1RN IL2 IL4 IL6
6	integument	MP:0010771	10.06	IL10 IL1B IL1RN IL4 IL6 MEFV
7	digestive/alimentary	MP:0005381	10.05	IL10 IL2 IL4 IL6 NLRP3 TLR2
8	mortality/aging	MP:0010768	10.02	IL10 IL1B IL1RN IL2 IL4 IL6
9	liver/biliary system	MP:0005370	9.97	IL10 IL2 IL4 IL6 MEFV NLRP3
10	reproductive system	MP:0005389	9.76	IL10 IL1RN IL2 IL4 IL6 MEFV
11	neoplasm	MP:0002006	9.73	IL10 IL1B IL2 IL6 TLR2 TNF
12	respiratory system	MP:0005388	9.43	IL10 IL2 IL4 IL6 TLR2 TNF
13	skeleton	MP:0005390	9.28	IL10 IL1B IL1RN IL4 IL6 MEFV

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Drugs & Therapeutics for Aphthous Stomatitis

Drugs for Aphthous Stomatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 148)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Infliximab

Approved

Phase 4

170277-31-3

Gastrointestinal Agents

Phase 4,Phase 3,Phase 2,Early Phase 1

Antirheumatic Agents

Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1

Dermatologic Agents

Phase 4,Phase 2,Early Phase 1

Minocycline

Approved, Investigational

Phase 3

10118-90-8

5281021

Dexamethasone

Approved, Investigational, Vet_approved

Phase 3,Early Phase 1

50-02-2

5743

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 3,Early Phase 1

1177-87-3

Hydroxocobalamin

Approved

Phase 3,Not Applicable

13422-51-0

11953898 44475014

Ethanol

Approved

Phase 3

64-17-5

702

Menthol

Approved

Phase 3

2216-51-5

16666

Neomycin

Approved, Vet_approved

Phase 3

1404-04-2

8378

Procaine

Approved, Investigational, Vet_approved

Phase 3

59-46-1

4914

Glycerol

Approved, Investigational

Phase 3

56-81-5

753

Adalimumab

Approved

Phase 2, Phase 3,Phase 3

331731-18-1

16219006

Azathioprine

Approved

Phase 3

446-86-6

2265

Prednisone

Approved, Vet_approved

Phase 3

53-03-2

5865

Miconazole

Approved, Investigational, Vet_approved

Phase 3,Not Applicable

22916-47-8

4189

Everolimus

Approved

Phase 3,Not Applicable

159351-69-6

6442177

Sirolimus

Approved, Investigational

Phase 3,Not Applicable

53123-88-9

46835353 6436030 5284616

Mycophenolic acid

Approved

Phase 3

24280-93-1

446541

Tacrolimus

Approved, Investigational

Phase 3

104987-11-3

445643 439492

Vitamin A

Approved, Nutraceutical, Vet_approved

Phase 3

11103-57-4, 68-26-8

445354

Cyanocobalamin

Approved, Nutraceutical

Phase 3,Not Applicable

68-19-9

44176380

Cobalamin

Experimental

Phase 3,Not Applicable

13408-78-1

6438156

Hormones

Phase 3,Phase 2

Anti-Inflammatory Agents

Phase 3,Phase 2,Phase 1,Early Phase 1

Anti-Infective Agents

Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

BB 1101

Phase 3,Early Phase 1

Anti-Bacterial Agents

Phase 3,Phase 2,Not Applicable,Early Phase 1

HIV Protease Inhibitors

Phase 3

Antiemetics

Phase 3,Phase 2,Early Phase 1

glucocorticoids

Phase 3,Phase 2

Hormone Antagonists

Phase 3,Phase 2

protease inhibitors

Phase 3

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 3,Phase 2

Peripheral Nervous System Agents

Phase 3,Phase 2,Early Phase 1

Autonomic Agents

Phase 3,Phase 2,Early Phase 1

Antineoplastic Agents, Hormonal

Phase 3,Phase 2

Trace Elements

Phase 3,Phase 2,Not Applicable

Micronutrients

Phase 3,Phase 2,Not Applicable

Retinol palmitate

Phase 3

retinol

Phase 3

Vitamins

Phase 3,Not Applicable

Vitamin B12

Phase 3,Not Applicable

Vitamin B 12

Phase 3,Not Applicable

Central Nervous System Depressants

Phase 3,Phase 2,Early Phase 1

Anesthetics

Phase 3,Phase 2,Early Phase 1

Anti-Ulcer Agents

Phase 3

Anesthetics, Local

Phase 3,Phase 2,Early Phase 1

Antacids

Phase 3

Interventional clinical trials:

(show top 50) (show all 56)

#	Name	Status	NCT ID	Phase	Drugs
1	Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery	Completed	NCT00688636	Phase 4	infliximab;placebo
2	The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus	Unknown status	NCT01083420	Phase 3	Minocycline;Dexamethasone
3	Prevention of Recurrent Aphthous Stomatitis Using Vitamins	Completed	NCT00527306	Phase 3
4	Efficacy of the Combination Bismuth + Neomycin + Procaine in the Treatment of Recurrent Aphthous Ulceration	Completed	NCT00857688	Phase 3	Bismu-Jet
5	A Study of Adalimumab for the Maintenance of Clinical Remission in Japanese Subjects With Crohn's Disease	Completed	NCT00445432	Phase 2, Phase 3
6	Efficacy and Safety of Two Treatment Algorithms in Adults With Moderate to Severe Crohn's Disease	Completed	NCT01235689	Phase 3	Prednisone;Azathioprine
7	Tacrolimus/Everolimus vs. Tacrolimus/MMF in Pediatric Heart Transplant Recipients Using the MATE Score	Recruiting	NCT03386539	Phase 3	Everolimus;Tacrolimus;Mycophenolate Mofetil
8	Herbal Treatment to Improve Chemotherapy Delivery	Not yet recruiting	NCT03716518	Phase 3	Tonifying Spleen and Kidney Sequential Regimen;Placebo of 'Tonifying Spleen and Kidney Sequential Regimen
9	Omega-3 and Quality of Life in Recurrent Aphthous Stomatitis Patients	Unknown status	NCT01831453	Phase 2	omega-3;placebo
10	Evaluation of Therapeutic Effect of 0.5 mg Colchicine and 5 mg Prednisolone on Oral Aphthae	Unknown status	NCT00723268	Phase 2	Prednisolone;Colchicine
11	Systemic Zinc Sulphate in Treatment of Recurrent Aphthous Ulcerations:A Doubleblind, Placebo Controled Study	Completed	NCT01210014	Phase 2	zinc sulphate 220mg/day in one dosage;placebo: one dosage
12	Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis	Completed	NCT01293968	Phase 2	Ibuprofen, Diphenhydramine and Aluminium MgS;Diphenhydramine and Aluminium MgS
13	Efficacy and Safety Study of Yunnan Baiyao on Minor Recurrent Aphthous Stomatitis	Completed	NCT01652625	Phase 2	Yunnan Baiyao toothpaste;Placebo toothpaste
14	Thalidomide for Treatment of Oral and Esophageal Aphthous Ulcers and HIV Viremia in Patients With HIV Infection	Completed	NCT00000790	Phase 2	Thalidomide
15	Topical "Non-Aromatic Very Rich in Steranes" (NAVS) Naphthalan for the Treatment of Oral Mucosal Diseases	Completed	NCT02920658	Phase 2	NAVS Naphthalan;0.05% Betamethasone dipropionate
16	Colchicine Randomized Double-Blind Controlled Crossover Study in Behcet's Disease	Completed	NCT00700297	Phase 2	Colchicine;Placebo
17	PillCam® Platform With the PillCam Crohn's Disease Capsule	Completed	NCT01631435	Phase 1, Phase 2
18	Anakinra for Behcet s Disease	Completed	NCT01441076	Phase 1, Phase 2	Anakinra
19	Thalidomide to Treat Oral Lesions in HIV-Infected Patients	Completed	NCT00001524	Phase 2	Thalidomide
20	Effectiveness and Safety of Lactobacillus Rhamnosus Lcr35® in the Treatment of Recurrent Aphthous Stomatitis	Recruiting	NCT02789605	Phase 2	Bacilor;Placebo
21	Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome	Recruiting	NCT03469232	Phase 1, Phase 2	Huanglian-Jiedu Decoction
22	Vedolizumab Post Op Study	Recruiting	NCT02834754	Phase 2	Vedolizumab;placebo
23	Efficacy of Adhesive Tablets in Treating Oral Ulcers (Aphthous)	Suspended	NCT00281723	Phase 2	Pro-Pe adhesive tablet
24	Efficacy, Safety and Tolerability of AIN457 in Moderate to Severe Active Crohn's Disease	Terminated	NCT00584740	Phase 2	AIN457;Placebo
25	Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of ITF2357 on Mucosal Healing in Patients With Moderate-to-severe Active Crohn's Disease	Terminated	NCT00792740	Phase 1, Phase 2	ITF2357;Placebo capsules
26	Effectiveness of Topical Thalidomide to Treat Chronic Graft-Versus-Host-Disease Related Stomatitis	Terminated	NCT00075023	Phase 2	Thalidomide Gel;Placebo Gel
27	Probiotics and Corticosteroids for Treating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA)	Withdrawn	NCT02535962	Phase 2
28	Clinical Evaluation of Fluid Extract of Chamomilla Tincture for Oral Aphthae	Completed	NCT01122147	Phase 1	chamomilla tincture mouthwash;placebo mouthwash
29	Niosomal Propolis as Oromucoadhesive Film: In-vitro, Ex-vivo & In-vivo Investigations	Completed	NCT03615820	Phase 1	Niosomal PPE oromucoadhesive film;Oromucoadhesive film
30	Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA)	Recruiting	NCT02775994	Phase 1	Canakinumab
31	Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis	Completed	NCT01501409	Not Applicable
32	Oral Vitamin B12 as Potential Treatment of Recurrent Aphthous Stomatitis	Completed	NCT00288769	Not Applicable	daily sublingual tablets Vitamin B12 1000 mcg versus placebo
33	Treatment of Recurrent Aphthous Stomatitis With Er,Cr:YSGG Laser Irradiation	Completed	NCT02925182	Not Applicable
34	The Effect of 2-DeNT Oral Topical Powder on Minor Recurrent Aphthous Ulcer	Completed	NCT02142543	Early Phase 1	2-DeNT powder;Placebo Comparator
35	A Trial of Pentoxifylline for the Treatment of Recurrent Aphthous Stomatitis	Completed	NCT00315679	Not Applicable	Pentoxifylline (also known as oxpentifylline)
36	Abdominal Ultrasound Examination in Non-celiac Wheat Sensitivity	Completed	NCT03017274
37	Evaluation and Treatment of Oral Soft Tissue Diseases	Completed	NCT00001601	Not Applicable
38	Special Investigation in Patients With Intestinal Behcet's Disease (All Case Investigation)	Completed	NCT01960790
39	The Vienna RAP Pilot Study	Completed	NCT01632605	Not Applicable	Sirolimus
40	Tokushima Night Guard for Recurrent Aphthous Stomatitis	Recruiting	NCT02890524	Early Phase 1
41	The Salivary and Faecal Microbiome of Recurrent Aphthous Stomatitis Patients Before and After Treatment With Probiotics	Recruiting	NCT02976922	Not Applicable
42	Apremilast for RAS	Recruiting	NCT03690544	Early Phase 1	Apremilast 30mg
43	Tonsillotomy or Follow-up in PFAPA Syndrome	Recruiting	NCT03331497	Not Applicable
44	Gynaecological Disorders in Not-celiac Wheat Sensitivity	Recruiting	NCT03027492	Not Applicable
45	Lactose Intolerance and Cow's Milk Protein Allergy in Non-celiac Wheat Sensitivity Patients	Recruiting	NCT03008252
46	Fibromyalgia-like Joint/Muscle Pain and Synovitis in Non-celiac Wheat Sensitivity Patients	Recruiting	NCT03022513	Not Applicable
47	Salivary Cytokines as Biomarker for Oral Health	Recruiting	NCT02807519
48	Oral Lesions In Non-Celiac Wheat Sensitivity Patients	Recruiting	NCT02421809
49	Entyvio (Vedolizumab) Long Term Safety Study	Recruiting	NCT02674308		Vedolizumab
50	Identification of Viruses Associated With Diseases of Unknown Cause	Enrolling by invitation	NCT00359268

Search NIH Clinical Center for Aphthous Stomatitis

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :

benzocaine

benzocaine pwdr

levonordefrin

thalidomide

Cochrane evidence based reviews: stomatitis, aphthous

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Genetic Tests for Aphthous Stomatitis

Genetic tests related to Aphthous Stomatitis:

#	Genetic test	Affiliating Genes
1	Oral Ulcer ²⁹

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Anatomical Context for Aphthous Stomatitis

MalaCards organs/tissues related to Aphthous Stomatitis:

⁴¹

Tongue, Bone, Heart, Tonsil, Monocytes, Testes, Neutrophil

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Publications for Aphthous Stomatitis

Articles related to Aphthous Stomatitis:

(show top 50) (show all 731)

#	Title	Authors	Year
1	Association of Serotonin Transporter Gene Polymorphism with Recurrent Aphthous Stomatitis. ( 29296268 )	Najafi S....Rezaei N.	2018
2	Tonsillar antimicrobial peptide (AMP) expression profiles of periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) patients. ( 29859567 )	Gazi U....Bahceciler N.O.	2018
3	Prevalence and psychological stress in recurrent aphthous stomatitis among female dental students in Saudi Arabia. ( 29785161 )	Ajmal M....Al-Qarni H.	2018
4	The association between minor recurrent aphthous stomatitis (RAS), children's poor oral condition, and underlying negativeA psychosocial habits and attitudes towards oral hygiene. ( 29653566 )	Tecco S....Gherlone E.F.	2018
5	Comorbidity of PFAPA (periodic fever, aphthous stomatitis, pharyngitis and adenitis) patients: a case control study. ( 29533751 )	Lantto U....Renko M.	2018
6	Gastric parietal cell and thyroid autoantibodies in recurrent aphthous stomatitis patients with concomitant oral lichen planus. ( 29753458 )	Wu Y.C....Sun A.	2018
7	Autosomal dominant deficiency of the interleukin-17F in recurrent aphthous stomatitis: Possible novel mutation in a new entity. ( 29458167 )	Zare Bidoki A....Rezaei N.	2018
8	Associations of IL-1, 6, and 10 Gene Polymorphisms with Susceptibility to Recurrent Aphthous Stomatitis: Insights from a Meta-Analysis. ( 29641282 )	Chen L....Zhang J.	2018
9	Risk factors for periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: a case-control study. ( 29799086 )	Kettunen S....Renko M.	2018
10	Association between interleukin family gene polymorphisms and recurrent aphthous stomatitis risk. ( 29550839 )	Zhou Y....Sun M.	2018
11	Association of the nod-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population. ( 29430721 )	Slezakova S....Izakovicova Holla L.	2018
12	The First International Conference on Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis Syndrome. ( 29246466 )	Harel L....Marshall G.S.	2018
13	Healthy lifestyle habits benefit remission of recurrent aphthous stomatitis and RAS type ulceration. ( 29327722 )	Ge L.	2018
14	Pregnancy complicated with PFAPA (periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis) syndrome: a case report. ( 29866074 )	Ota K....Mizunuma H.	2018
15	The role of tonsillectomy in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome; a literature review. ( 29483843 )	FA...A9ymar K.	2018
16	Hematinic dei-8ciencies in patients with recurrent aphthous stomatitis: variations by gender and age. ( 29476670 )	Bao Z.X....Liu L.X.	2018
17	Salivary levels of TNF-I+ in patients with recurrent aphthous stomatitis: A cross-sectional study. ( 29732020 )		2018
18	Relationship between salivary calprotectin levels and recurrent aphthous stomatitis: A preliminary study. ( 29519972 )		2018
19	Examination of serum hematinics and autoantibodies is important for treatment of recurrent aphthous stomatitis. ( 29336939 )		2018
20	Analysis of Dietary Related Factors of Recurrent Aphthous Stomatitis among College Students. ( 29681971 )		2018
21	Haematinic deficiencies and patient clinical profiles in Polish patients with recurrent aphthous stomatitis (RAS). ( 29499093 )		2018
22	The association between interleukin polymorphism and recurrent aphthous stomatitis: A meta-analysis. ( 29800802 )		2018
23	Evidence that Enterobius vermicularis plays a causative role for PFAPA and recurrent aphthous stomatitis. ( 29856193 )		2018
24	Evaluation and Comparison of Total Antioxidant Capacity of Saliva Between Patients with Recurrent Aphthous Stomatitis and Healthy Subjects. ( 29755602 )		2018
25	Association Between Anxiety, Depression, and Salivary Cortisol Levels in Patients with Recurrent Aphthous Stomatitis. ( 30319874 )	Polat C...?etiner H	2018
26	Celiac disease-specific and inflammatory bowel disease-related antibodies in patients with recurrent aphthous stomatitis. ( 30446336 )	Bijeli? B...Andrejevi? S	2018
27	Treatment options for periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome in children and adults: a narrative review. ( 30488366 )	Gaggiano C...Cantarini L	2018
28	Establishment of Role of IL-2, IL-10 and IL-12 in Patients with Recurrent Aphthous Stomatitis-A Clinical Study. ( 30498180 )	Bhosale SS...Shaikh MIK	2018
29	Severe HIV-associated aphthous stomatitis treated with etanercept. ( 30528070 )	Rzepecki V...Makinson A	2018
30	Chitosan/pvp-based mucoadhesive membranes as a promising delivery system of betamethasone-17-valerate for aphthous stomatitis. ( 29628256 )	Siz?lio RH...Nunes RS	2018
31	Correction: Association between interleukin family gene polymorphisms and recurrent aphthous stomatitis risk. ( 29985443 )	Zhou Y...Sun M	2018
32	Interleukin-4 and Interleukin-4 Receptor Alpha Gene Polymorphisms in Recurrent Aphthous Stomatitis. ( 29985726 )	Najafi S...Rezaei N	2018
33	Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case-control frequency-matched study. ( 30009475 )	Qin L...Wu SY	2018
34	Familial Mediterranean fever and periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: shared features and main differences. ( 30019226 )	Adrovic A...Kasapcopur O	2018
35	Effect of 0.5% Chitosan mouthwash on recurrent aphthous stomatitis: a randomized double-blind crossover clinical trial. ( 30034658 )	Rahmani F...Motallebnejad M	2018
36	Comment on "Mean Platelet Volume: A Reliable Marker of Inflammation in Recurrent Aphthous Stomatitis and Behçet's Disease?" ( 30050826 )	Avsar E	2018
37	Aphthous Stomatitis Major in a 4-Month-Old Infant. ( 30297194 )	Wong BJW...Campbell KM	2018
38	Aphthous Stomatitis and Laryngitis, Another Form of Presentation of an IgG4-Related Disease? ( 30297197 )	Su?rez-D?az S...Caminal-Montero L	2018
39	Patients who seek professional treatment of recurrent aphthous stomatitis probably have an increased risk of having head and neck cancer and other types of cancers. ( 30340756 )	Brignardello-Petersen R	2018
40	Recurrent aphthous stomatitis and gene variability in selected interleukins: a case-control study. ( 30341786 )	Borilova Linhartova P...Izakovicova Holla L	2018
41	Comorbidity profiles among patients with recurrent aphthous stomatitis: A case-control study. ( 30348492 )	Lin KC...Wu SY	2018
42	Familial Mediterranean Fever Is Commonly Diagnosed in Children in Israel with Periodic Fever Aphthous Stomatitis, Pharyngitis, and Adenitis Syndrome. ( 30361059 )	Butbul Aviel Y...Amarilyo G	2018
43	Vitamin D levels in patients with recurrent aphthous stomatitis. ( 30413195 )	?ztekin A...?ztekin C	2018
44	Recurrent aphthous stomatitis - Etiology, serum autoantibodies, anemia, hematinic deficiencies, and management. ( 30446298 )	Chiang CP...Sun A	2018
45	Therapeutic effect of Aloe vera and silver nanoparticles on acid-induced oral ulcer in gamma-irradiated mice. ( 29412224 )	El-Batal AI...Ahmed SF	2018
46	Gastrointestinal: Improvement of refractory oral ulcer of Behçet's disease after eradication of Helicobacter pylori. ( 29469234 )	Okano A...Ohana M	2018
47	Endothelin-1 Elicits TRP-Mediated Pain in an Acid-Induced Oral Ulcer Model. ( 29518348 )	Nodai T...Inenaga K	2018
48	Curative effect of oral ulcer powder on the treatment of recurrent aphthous ulcer. ( 29735470 )	Zhu S...Lu J	2018
49	Polysaccharides from tubers of Bletilla striata: Physicochemical characterization, formulation of buccoadhesive wafers and preliminary study on treating oral ulcer. ( 30227203 )	Liao Z...Qu Y	2018
50	Oral ulcer due to dabigatran capsule. ( 30287622 )	Kuno Y...Ikeda T	2018

Sources

Genes for Aphthous Stomatitis

Genes related to Aphthous Stomatitis (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MEFV	MEFV, Pyrin Innate Immunity Regulator	Protein Coding	23.83	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	IL1B	Interleukin 1 Beta	Protein Coding	23.07	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	23.07	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	TNF	Tumor Necrosis Factor	Protein Coding	22.89	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	IL6	Interleukin 6	Protein Coding	22.63	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	IL10	Interleukin 10	Protein Coding	22.21	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	IL1RN	Interleukin 1 Receptor Antagonist	Protein Coding	21.7	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	IL4	Interleukin 4	Protein Coding	21.2	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	SPAG7	Sperm Associated Antigen 7	Protein Coding	21.18	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	HLA-B	Major Histocompatibility Complex, Class I, B	Protein Coding	21.18	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	HLA-A	Major Histocompatibility Complex, Class I, A	Protein Coding	21.1	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	IL2	Interleukin 2	Protein Coding	20.92	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	TLR2	Toll Like Receptor 2	Protein Coding	20.87	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Aphthous Stomatitis

Sources

Expression for Aphthous Stomatitis

Search GEO for disease gene expression data for Aphthous Stomatitis.

Sources

Pathways for Aphthous Stomatitis

Pathways related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 75)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.96	HLA-A HLA-B IL10 IL1B IL1RN IL2
2	PEDF Induced Signaling ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Cytokine-cytokine receptor interaction ³⁷ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Mediated Glucocorticoid Regulation ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.63	IL10 IL1B IL1RN IL2 IL4 IL6
3	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.41	IL10 IL1B IL2 IL4 IL6 TLR2
4	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.34	HLA-A HLA-B IL10 IL1B IL1RN IL2
5	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.27	IL10 IL1B IL2 IL4 IL6 TNF
6	Human cytomegalovirus infection ³⁷ Show member pathways Hepatitis B ³⁷ Human immunodeficiency virus 1 infection ³⁷ Kaposi sarcoma-associated herpesvirus infection ³⁷	13.07	HLA-A HLA-B IL1B IL6 TLR2 TNF
7	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	13.04	HLA-A HLA-B IL2 IL4 IL6 TLR2
8	Toll-like Receptor Signaling Pathway ³⁷ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁷ NOD-like receptor signaling pathway ³⁷ NOD-like Receptor Signaling Pathways ⁶⁵ Regulation of toll-like receptor signaling pathway ¹	13.01	IL10 IL1B IL2 IL6 MEFV NLRP3
9	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.82	HLA-A HLA-B IL10 IL1B IL2 IL4
10	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.73	IL1B IL2 IL6 TLR2 TNF
11	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.63	IL10 IL1B IL2 IL6 TNF
12	Immune response NFAT in immune response ²² Show member pathways Immune response CD28 signaling ²² Immune response ICOS pathway in T-helper cell ²² Immune response T cell receptor signaling pathway ²²	12.6	IL10 IL2 IL4 TNF
13	Influenza A ³⁷ Show member pathways Herpes simplex infection ³⁷ Measles ³⁷	12.6	HLA-A HLA-B IL1B IL2 IL4 IL6
14	Immune response Role of DAP12 receptors in NK cells ²² Show member pathways Immune response CD16 signaling in NK cells ²² Natural killer cell mediated cytotoxicity ³⁷	12.57	HLA-A HLA-B IL2 IL4 TNF
15	Th17 cell differentiation ³⁷ Show member pathways IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	12.54	IL10 IL1B IL2 IL4 IL6 TLR2
16	Human T-cell leukemia virus 1 infection ³⁷	12.49	HLA-A HLA-B IL2 IL6 TNF
17	NF-kappaB Signaling ⁴	12.49	IL10 IL1B IL1RN IL2 IL4 TLR2
18	T cell receptor signaling pathway ³⁷ Show member pathways T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.47	IL10 IL1B IL2 IL4 IL6 TNF
19	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁶ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.41	IL1B IL2 IL4 IL6 TNF
20	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁷ Interleukin-17 signaling ⁶⁶ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.41	IL1B IL4 IL6 TLR2 TNF
21	JAK-STAT signaling pathway (KEGG) ³⁷ Show member pathways Interleukin-19, 20, 22, 24 ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵	12.4	IL10 IL2 IL4 IL6
22	Epstein-Barr virus infection ³⁷	12.37	HLA-A HLA-B IL6 TLR2 TNF
23	Toxoplasmosis ³⁷ Show member pathways Leishmaniasis ³⁷	12.33	IL10 IL1B IL4 TLR2 TNF
24	Tuberculosis ³⁷	12.31	IL10 IL1B IL6 TLR2 TNF
25	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways Immune response IL-1 signaling pathway ²² Mucin expression in CF via TLRs, EGFR signaling pathways ²²	12.3	IL1B IL1RN IL6 TLR2 TNF
26	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	12.26	IL1B IL4 IL6 TLR2 TNF
27	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.25	IL10 IL1B IL1RN IL6 TNF
28	C-type lectin receptor signaling pathway ³⁷ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.21	IL10 IL1B IL2 IL6 NLRP3 TNF
29	Microglia Activation During Neuroinflammation: Overview ⁶⁵ Show member pathways Microglia Activation During Neuroinflammation: Microglia Activation ⁶⁵	12.13	IL1B IL4 IL6 TLR2 TNF
30	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶⁴ Interferon alpha/beta signaling ⁶⁶ Regulation of IFNA signaling ⁶⁶	12.13	HLA-A HLA-B IL10 IL1B IL2 IL4
31	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	12.12	IL10 IL1B IL2 IL4 IL6
32	Phagosome ³⁷	12.11	HLA-A HLA-B TLR2
33	Spinal Cord Injury ¹	12.1	IL1B IL2 IL4 IL6 TNF
34	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	12.07	IL10 IL2 IL4 IL6 TNF
35	Interleukin-4 and 13 signaling ⁶⁶	12.06	IL10 IL1B IL4 IL6 TNF
36	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	12.05	HLA-A IL1B IL2 IL4
37	MAPK Pathway ⁷² Show member pathways Toll-like Receptor Pathway ⁷²	12.01	IL1B IL2 TLR2
38	Hematopoietic cell lineage ³⁷	11.98	IL1B IL4 IL6 TNF
39	Th1 Differentiation Pathway ⁶⁵ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁵	11.96	IL10 IL1B IL2 IL6 TLR2 TNF
40	TNF signaling pathway ³⁷	11.95	IL1B IL6 TNF
41	Amoebiasis ³⁷	11.95	IL10 IL1B IL6 TLR2 TNF
42	Rheumatoid arthritis ³⁷	11.94	IL1B IL6 TLR2 TNF
43	AGE-RAGE signaling pathway in diabetic complications ³⁷	11.91	IL1B IL6 TNF
44	Jak-Stat Signaling Pathway (sino) ⁶⁷	11.86	IL10 IL2 IL6
45	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.85	IL10 IL1B IL2 IL4 TNF
46	Glucocorticoid receptor regulatory network ¹	11.82	IL2 IL4 IL6
47	Pertussis ³⁷	11.82	IL10 IL1B IL6 NLRP3 TNF
48	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.79	IL2 IL4 TNF
49	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.79	IL10 IL1B IL2 IL6 TNF
50	Lung fibrosis ¹	11.77	IL1B IL4 IL6 TNF

Sources

GO Terms for Aphthous Stomatitis

Cellular components related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.7	IL10 IL1B IL1RN IL2 IL4 IL6
2	MHC class I protein complex	GO:0042612	9.26	HLA-A HLA-B
3	extracellular region	GO:0005576	9.23	IL10 IL1B IL1RN IL2 IL4 IL6
4	phagocytic vesicle membrane	GO:0030670	9.13	HLA-A HLA-B TLR2

Biological processes related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 64)

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of signaling receptor activity	GO:0010469	9.95	IL10 IL1B IL1RN IL2 IL4 IL6
2	positive regulation of JNK cascade	GO:0046330	9.89	IL1B IL1RN TNF
3	positive regulation of inflammatory response	GO:0050729	9.88	IL2 TLR2 TNF
4	positive regulation of DNA-binding transcription factor activity	GO:0051091	9.88	IL10 IL1B IL6 TNF
5	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.88	IL1B IL6 NLRP3 TLR2 TNF
6	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.87	IL2 IL4 IL6
7	negative regulation of inflammatory response	GO:0050728	9.87	IL10 IL2 MEFV NLRP3
8	defense response to Gram-positive bacterium	GO:0050830	9.86	IL6 NLRP3 TLR2 TNF
9	positive regulation of NIK/NF-kappaB signaling	GO:1901224	9.83	IL1B TLR2 TNF
10	positive regulation of interferon-gamma production	GO:0032729	9.81	IL1B IL2 TNF
11	positive regulation of T cell proliferation	GO:0042102	9.81	IL1B IL2 IL4 IL6
12	positive regulation of JUN kinase activity	GO:0043507	9.8	IL1B IL1RN TNF
13	cellular response to lipopolysaccharide	GO:0071222	9.8	IL10 IL1B IL1RN IL6 NLRP3 TNF
14	lipopolysaccharide-mediated signaling pathway	GO:0031663	9.78	IL1B TLR2 TNF
15	positive regulation of interleukin-8 production	GO:0032757	9.77	IL1B TLR2 TNF
16	negative regulation of neurogenesis	GO:0050768	9.77	IL1B IL6 TNF
17	response to glucocorticoid	GO:0051384	9.77	IL10 IL1B IL1RN IL6 TNF
18	positive regulation of T cell differentiation	GO:0045582	9.73	IL2 IL4
19	microglial cell activation	GO:0001774	9.73	TLR2 TNF
20	negative regulation of lipid catabolic process	GO:0050995	9.73	IL1B TNF
21	regulation of I-kappaB kinase/NF-kappaB signaling	GO:0043122	9.73	IL1B TNF
22	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.73	IL1B TNF
23	negative regulation of growth of symbiont in host	GO:0044130	9.72	IL10 TNF
24	negative regulation of interleukin-12 production	GO:0032695	9.72	IL10 MEFV
25	positive regulation of immunoglobulin secretion	GO:0051024	9.72	IL2 IL6
26	response to molecule of bacterial origin	GO:0002237	9.72	IL10 TLR2
27	negative regulation of heterotypic cell-cell adhesion	GO:0034115	9.72	IL10 IL1RN
28	positive regulation of chemokine production	GO:0032722	9.72	IL6 TLR2 TNF
29	positive regulation of isotype switching to IgG isotypes	GO:0048304	9.71	IL2 IL4
30	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	GO:0002480	9.71	HLA-A HLA-B
31	negative regulation of lipid storage	GO:0010888	9.71	IL6 TNF
32	positive regulation of interleukin-13 production	GO:0032736	9.71	IL4 NLRP3
33	positive regulation of glial cell proliferation	GO:0060252	9.71	IL1B IL6 TNF
34	endothelial cell apoptotic process	GO:0072577	9.7	IL10 TNF
35	positive regulation of chemokine biosynthetic process	GO:0045080	9.7	IL1B TNF
36	positive regulation of heterotypic cell-cell adhesion	GO:0034116	9.7	IL10 IL1B TNF
37	cytokine-mediated signaling pathway	GO:0019221	9.7	IL10 IL1B IL1RN IL2 IL4 IL6
38	antigen processing and presentation of endogenous peptide antigen via MHC class Ib	GO:0002476	9.69	HLA-A HLA-B
39	negative regulation of glutamate secretion	GO:0014050	9.68	IL1B IL1RN
40	positive regulation of MHC class II biosynthetic process	GO:0045348	9.68	IL10 IL4
41	regulation of establishment of endothelial barrier	GO:1903140	9.68	IL1B TNF
42	negative regulation of cytokine secretion involved in immune response	GO:0002740	9.68	IL10 TNF
43	positive regulation of T-helper 2 cell cytokine production	GO:2000553	9.67	IL6 NLRP3
44	interleukin-1 beta production	GO:0032611	9.67	IL1B NLRP3
45	negative regulation of interleukin-1-mediated signaling pathway	GO:2000660	9.67	IL1RN IL6
46	positive regulation of fever generation	GO:0031622	9.66	IL1B TNF
47	protection from natural killer cell mediated cytotoxicity	GO:0042270	9.66	HLA-A HLA-B
48	regulation of isotype switching	GO:0045191	9.65	IL10 IL4
49	sequestering of triglyceride	GO:0030730	9.65	IL1B TNF
50	positive regulation of interleukin-6 production	GO:0032755	9.65	IL1B IL1RN IL6 TLR2 TNF

Molecular functions related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peptidoglycan binding	GO:0042834	9.26	NLRP3 TLR2
2	growth factor activity	GO:0008083	9.26	IL10 IL2 IL4 IL6
3	cytokine activity	GO:0005125	9.17	IL10 IL1B IL1RN IL2 IL4 IL6
4	interleukin-1 receptor binding	GO:0005149	9.16	IL1B IL1RN

Sources

Sources for Aphthous Stomatitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

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⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

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¹⁶ DrugBank

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¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Aphthous Stomatitis

Aliases & Classifications for Aphthous Stomatitis

MalaCards integrated aliases for Aphthous Stomatitis:

Classifications:

External Ids:

Summaries for Aphthous Stomatitis

Related Diseases for Aphthous Stomatitis

Diseases related to Aphthous Stomatitis via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Aphthous Stomatitis:

Symptoms & Phenotypes for Aphthous Stomatitis

UMLS symptoms related to Aphthous Stomatitis:

MGI Mouse Phenotypes related to Aphthous Stomatitis:

Drugs & Therapeutics for Aphthous Stomatitis

Drugs for Aphthous Stomatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cochrane evidence based reviews: stomatitis, aphthous

Genetic Tests for Aphthous Stomatitis

Genetic tests related to Aphthous Stomatitis:

Anatomical Context for Aphthous Stomatitis

MalaCards organs/tissues related to Aphthous Stomatitis:

Publications for Aphthous Stomatitis

Articles related to Aphthous Stomatitis:

Genes for Aphthous Stomatitis

Genes related to Aphthous Stomatitis (0 elite genes):

Variations for Aphthous Stomatitis

Expression for Aphthous Stomatitis

Pathways for Aphthous Stomatitis

Pathways related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

GO Terms for Aphthous Stomatitis

Cellular components related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

Biological processes related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

Molecular functions related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

Sources for Aphthous Stomatitis

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :