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MCID: APH001
MIFTS: 57

Aphthous Stomatitis

Categories: Oral diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Aphthous Stomatitis

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MalaCards integrated aliases for Aphthous Stomatitis:

Name: Aphthous Stomatitis 12 74 52 15 71
Oral Ulcer 12 54 71
Minor Oral Aphthous Ulceration 71
Stomatitis, Aphthous 43
Aphthous Ulceration 12
Oral Aphthous Ulcer 12
Oral Aphthae 12
Canker Sores 42
Canker Sore 12
Aphtha 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Oral diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:9663
ICD9CM 34 528.2
MeSH 43 D013281
NCIt 49 C62546
SNOMED-CT 67 83312008
UMLS 71 C0038363 C0149745 C0585213
Sources

Summaries for Aphthous Stomatitis

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MedlinePlus : 42 Canker sores are small, round sores in your mouth. They can be on the inside of your cheek, under your tongue, or in the back of your throat. They usually have a red edge and a gray center. They can be quite painful. They are not the same as cold sores, which are caused by herpes simplex. Canker sores aren't contagious. They may happen if you have a viral infection. They may also be triggered by stress, food allergies, lack of vitamins and minerals, hormonal changes or menstrual periods. In some cases the cause is unknown. In most cases, the sores go away by themselves. Some ointments, creams or rinses may help with the pain. Avoiding hot, spicy food while you have a canker sore also helps.

MalaCards based summary : Aphthous Stomatitis, also known as oral ulcer, is related to mevalonic aciduria and chronic active epstein-barr virus infection, and has symptoms including halitosis, enanthema and snoring. An important gene associated with Aphthous Stomatitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Vitamin C and Vitamins have been mentioned in the context of this disorder. Affiliated tissues include bone, tongue and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A stomatitis characterized by the repeated formation of benign and non-contagious mouth ulcers.

Wikipedia : 74 Aphthous stomatitis is a common condition characterized by the repeated formation of benign and... more...

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Related Diseases for Aphthous Stomatitis

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Diseases related to Aphthous Stomatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 864)
# Related Disease Score Top Affiliating Genes
1 mevalonic aciduria 32.6 NLRP3 MEFV IL1RN IL1B
2 chronic active epstein-barr virus infection 32.4 IL2 IL10 IFNG
3 orofacial granulomatosis 32.4 TNF IL4 IL10 IFNG
4 mouth disease 32.3 TLR4 IL6 IL1B IL10 IFNG
5 cervical adenitis 32.0 NLRP3 MEFV IL1RN IL1B
6 glossitis 31.2 TNF IL6 IL1B
7 pharyngitis 31.1 TNF NLRP3 MEFV IL6 IL1RN IL1B
8 ige responsiveness, atopic 31.1 IL4 IL10 IFNG
9 encephalitis 31.0 TNF IL6 IL1B IL10
10 burning mouth syndrome 30.9 TNF IL6 IL2 IL1B
11 lichen planus 30.8 TNF IL6 IL4 IL2 IL10 IFNG
12 hereditary periodic fever syndrome 30.8 TNF NLRP3 MEFV
13 vasculitis 30.8 TNF MEFV IL6 HLA-B
14 chickenpox 30.8 TNF IL6 IL4 IL2 IL10 IFNG
15 oral candidiasis 30.8 IL1RN IL1A CXCL8
16 meningoencephalitis 30.8 TNF IL6 IL10
17 proliferative glomerulonephritis 30.7 IL6 IL4 IFNG
18 peptic ulcer disease 30.7 TNF IL1RN IL1B IL10 CXCL8
19 laryngitis 30.7 TNF IL6 IL1B IL1A
20 cyclic neutropenia 30.7 TNF IL1B IFNG CXCL8 CSF2
21 urticaria 30.6 TNF NLRP3 IL6 IL4
22 spondyloarthropathy 1 30.5 TNF TLR4 IL1RN HLA-B
23 acute disseminated encephalomyelitis 30.5 IL1B IL10 HLA-B
24 hypopyon 30.5 IL6 IL1RN HLA-B
25 pustulosis of palm and sole 30.5 TNF IL1RN CXCL8
26 periodic fever, familial, autosomal dominant 30.5 TNF NLRP3 MEFV IL6 IL1RN IL1B
27 histoplasmosis 30.5 TNF IFNG HLA-B HLA-A
28 viral encephalitis 30.5 TNF IL6 IL1B IL10 CXCL8
29 atrophic gastritis 30.4 TNF IL6 IL1RN IL1B IL10 CXCL8
30 gastritis 30.4 TNF TLR4 IL6 IL1RN IL1B IL10
31 hidradenitis 30.4 TNF TLR4 IFNG
32 hidradenitis suppurativa 30.4 TNF TLR4 IFNG
33 liver disease 30.4 TNF IL6 IL1B IL1A CXCL8
34 gastric ulcer 30.4 TNF IL6 IL1RN IL1B CXCL8
35 chronic graft versus host disease 30.4 IL1A IL10 IFNG
36 genital herpes 30.4 TLR2 IL4 IL18 IL10
37 spondylitis 30.4 TNF IL6 IL1RN IL10 IFNG HLA-B
38 chikungunya 30.4 TNF IL6 IL1B IL18
39 wells syndrome 30.3 NLRP3 MEFV IL2 IL1B CXCL8
40 crohn's colitis 30.3 TNF IL2 IL1B IFNG CXCL8
41 cervicitis 30.3 TLR4 TLR2 IL6 IL2 CXCL8
42 pyoderma 30.3 TNF NLRP3 MEFV IL1RN CXCL8
43 pyoderma gangrenosum 30.3 TNF NLRP3 MEFV IL1RN CXCL8
44 lymphopenia 30.3 IL6 IL4 IL2 IL18 IL10 IFNG
45 deficiency anemia 30.3 TNF IL6 HLA-B CSF2 ACE
46 iritis 30.2 TNF IL6 HLA-B ACE
47 stomatitis 30.2 TNF TLR4 TLR2 NLRP3 MEFV IL6
48 hypersplenism 30.2 TLR4 IL4 IFNG CSF2
49 erythema multiforme 30.2 TNF IL6 IL4 IL2 IFNG CXCL8
50 gastroesophageal reflux 30.2 TNF IL6 IL4 IL1RN IL1B CXCL8

Graphical network of the top 20 diseases related to Aphthous Stomatitis:



Diseases related to Aphthous Stomatitis
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Symptoms & Phenotypes for Aphthous Stomatitis

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UMLS symptoms related to Aphthous Stomatitis:


halitosis, enanthema, snoring, oral mucosal blisters, oral manifestations, sore mouth

GenomeRNAi Phenotypes related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.89 ACE CXCL8 IL10 IL18 IL1A IL1B
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.89 ACE CXCL8 IL10 IL18 IL1A IL1B

MGI Mouse Phenotypes related to Aphthous Stomatitis:

45 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.44 ACE CD40 CSF2 IFNG IL10 IL18
2 homeostasis/metabolism MP:0005376 10.42 ACE CD40 CSF2 IFNG IL10 IL18
3 immune system MP:0005387 10.41 ACE CD40 CSF2 IFNG IL10 IL18
4 growth/size/body region MP:0005378 10.4 ACE CSF2 IFNG IL10 IL18 IL1B
5 cardiovascular system MP:0005385 10.38 ACE CSF2 IFNG IL10 IL18 IL1A
6 cellular MP:0005384 10.37 CSF2 IFNG IL10 IL18 IL1RN IL2
7 integument MP:0010771 10.3 CSF2 IFNG IL10 IL18 IL1A IL1B
8 mortality/aging MP:0010768 10.28 ACE CSF2 IFNG IL10 IL18 IL1B
9 digestive/alimentary MP:0005381 10.25 IFNG IL10 IL18 IL2 IL4 IL6
10 endocrine/exocrine gland MP:0005379 10.24 ACE CD40 CSF2 IFNG IL10 IL2
11 adipose tissue MP:0005375 10.18 ACE CSF2 IL18 IL6 NLRP3 TLR2
12 liver/biliary system MP:0005370 10.17 ACE IFNG IL10 IL2 IL4 IL6
13 neoplasm MP:0002006 10.11 ACE CSF2 IFNG IL10 IL1A IL1B
14 nervous system MP:0003631 10.1 CD40 CSF2 IFNG IL10 IL18 IL1B
15 reproductive system MP:0005389 9.93 ACE CSF2 IFNG IL10 IL1RN IL2
16 renal/urinary system MP:0005367 9.91 ACE CD40 CSF2 IFNG IL4 IL6
17 respiratory system MP:0005388 9.61 CSF2 IFNG IL10 IL2 IL4 IL6
18 skeleton MP:0005390 9.44 CD40 CSF2 IFNG IL10 IL1B IL1RN
Sources

Drugs & Therapeutics for Aphthous Stomatitis

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Drugs for Aphthous Stomatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 147)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
2 Vitamins Phase 4
3 Anti-Infective Agents Phase 4
4 Aloe Phase 4
5 Chlorhexidine gluconate Phase 4
6 Disinfectants Phase 4
7 Anti-Infective Agents, Local Phase 4
8
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
9
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
10
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
11
Flavin Mononucleotide Approved, Investigational Phase 3 146-17-8 643976
12
Glycerol Approved, Investigational Phase 3 56-81-5 753
13
Adalimumab Approved Phase 2, Phase 3 331731-18-1 16219006
14
tannic acid Approved Phase 2, Phase 3 1401-55-4
15
Sirolimus Approved, Investigational Phase 2, Phase 3 53123-88-9 5284616 6436030 46835353
16
Benzocaine Approved, Investigational Phase 2, Phase 3 1994-09-7, 94-09-7 2337
17
Everolimus Approved Phase 2, Phase 3 159351-69-6 6442177 70789204
18
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
19
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
20
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 3 83-88-5 493570
21
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 68-26-8, 11103-57-4, 22737-96-8 445354 9904001
22 Trace Elements Phase 3
23 Nutrients Phase 3
24 Vitamin B9 Phase 3
25 Folate Phase 3
26 Micronutrients Phase 3
27 Gastrointestinal Agents Phase 3
28 Antiemetics Phase 3
29 Autonomic Agents Phase 3
30 Antineoplastic Agents, Hormonal Phase 3
31 Analgesics Phase 3
32 BB 1101 Phase 3
33 Analgesics, Non-Narcotic Phase 3
34 Anti-Inflammatory Agents, Non-Steroidal Phase 3
35 HIV Protease Inhibitors Phase 3
36
protease inhibitors Phase 3
37 Vitamin B2 Phase 3
38 Mesalamine Phase 3 89-57-6
39 Photosensitizing Agents Phase 3
40 retinol Phase 3
41 Retinol palmitate Phase 3
42 Angiogenesis Inhibitors Phase 3
43 Immunologic Factors Phase 2, Phase 3
44 Anti-Bacterial Agents Phase 2, Phase 3
45 Immunosuppressive Agents Phase 2, Phase 3
46 Antihypertensive Agents Phase 2, Phase 3
47 Antibiotics, Antitubercular Phase 2, Phase 3
48 Antifungal Agents Phase 2, Phase 3
49
Methylcobalamin Approved, Investigational Phase 2 13422-55-4
50
Hydroxocobalamin Approved Phase 2 13422-51-0 11953898 15589840

Interventional clinical trials:

(show top 50) (show all 67)
# Name Status NCT ID Phase Drugs
1 Aloe Vera and Chlorhexidine as Preventive Oral Antiseptics Against the Appearance of Traumatic Oral Ulcers in Patients With Fixed Orthodontics: a Randomized Clinical Trial Completed NCT03633292 Phase 4 Antiseptic clorhexidine gel (Lacer, Barcelona, Spain);Master formula of aloe vera gel 80%
2 The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus. A Randomized Controlled Trial Unknown status NCT01083420 Phase 3 Minocycline;Dexamethasone
3 The Efficacy of Topically Applied Mesalazine Sustained-Release Tablets in Oral Lesions of Crohn's Disease Unknown status NCT02769494 Phase 3 Mesalazine Sustained-Release Tablets;Riboflavin Sodium Phosphate Injection
4 Randomized Controlled Trials of Diet and Lifestyle Intervention to Promote Chinese Postpartum Women's Health Unknown status NCT01039051 Phase 2, Phase 3
5 Prevention of Recurrent Aphthous Stomatitis Using Vitamins Completed NCT00527306 Phase 3
6 A Multi-Center, Randomized, Double-blind, Placebo-controlled Study of Adalimumab for the Maintenance of Clinical Remission in Japanese Subjects With Crohn's Disease Completed NCT00445432 Phase 2, Phase 3
7 Randomized Controlled Double-blind Vs. Placebo Multicentre Study on the Safety and Effectiveness of Thalidomide in the Treatment of Refractory Crohn's Disease and Ulcerative Colitis. Completed NCT00720538 Phase 3 Thalidomide;placebo
8 EFFECTS OF SIROLIMUS ON DISEASE PROGRESSION IN PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE AND SEVERE RENAL INSUFFICIENCY Terminated NCT01223755 Phase 2, Phase 3 Sirolimus;conventional therapy
9 Evaluation of Therapeutic Effect of 0.5 mg Colchicine and 5 mg Prednisolone on Oral Aphthae Unknown status NCT00723268 Phase 2 Prednisolone;Colchicine
10 Therapeutic Effect of Systemic Omega-3 Polyunsaturated Fatty Acids On Quality of Life in Patients Suffering From Recurrent Aphthous Stomatitis Unresponsive to Topical Therapy. Unknown status NCT01831453 Phase 2 omega-3;placebo
11 Efficacy and Safety of FORRAD® for the Management of Radiation-induced Mucositis in Patients With Nasopharyngeal Carcinoma Receiving IMRT: A Single-center, Randomized Controlled Trial Unknown status NCT02735317 Phase 2 Oral Ulcer Gargle (FORRAD®);Quadruple mixture, composed of dexamethasone, gentamicin, vitamin B12, and procaine
12 Sucralfate to Improve Oral Intake in Children With Infectious Oral Ulcers: a Randomized, Double-blind, Placebo-Controlled Trial Unknown status NCT03241030 Phase 2 Sucralfate;Acetaminophen;Ibuprofen
13 Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis Completed NCT01293968 Phase 2 Ibuprofen, Diphenhydramine and Aluminium MgS;Diphenhydramine and Aluminium MgS
14 Efficacy and Safety Study of Yunnan Baiyao on Minor Recurrent Aphthous Stomatitis Completed NCT01652625 Phase 2 Yunnan Baiyao toothpaste;Placebo toothpaste
15 Thalidomide for Treatment of Oral and Esophageal Aphthous Ulcers and HIV Viremia in Patients With HIV Infection Completed NCT00000790 Phase 2 Thalidomide
16 Zinc Sulphate in Treatment of Recurrent Aphthous Stomatitis Completed NCT01210014 Phase 2 zinc sulphate 220mg/day in one dosage;placebo: one dosage
17 Nonaromatic Naphthalan - Composition Study and Biological Effects on Epithelial Tissues Completed NCT02920658 Phase 2 NAVS Naphthalan;0.05% Betamethasone dipropionate
18 Phase II, Multicenter, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Ranging Study of the Effects of RK-0202 on Oral Mucositis in Patients Receiving Radiation Therapy for Tumors of the Oral Cavity, Oropharynx, Nasopharynx, Salivary Glands or Supraglottic Region Completed NCT00230191 Phase 2 RK-0202
19 Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome (Acute Pericoronitis, Minor Recurrent Aphthous Stomatitis and Recurrent Herpes Simplex Labialis) Recruiting NCT03469232 Phase 1, Phase 2 Huanglian-Jiedu Decoction
20 Clinical Protocol for Administration of Topical Pentoxifylline Gel on Behcet's Disease Oral Ulcers Recruiting NCT03888846 Phase 2 Pentoxifylline;Colchicine
21 Use of Ustekinumab (Anti-IL-12/23p40 Monoclonal Antibody) in Patients With Leukocyte Adhesion Deficiency Type 1 (LAD1) Who Have Inflammatory Pathology Recruiting NCT03366142 Phase 1, Phase 2 Ustekinumab
22 Treatment of Idiopathic and Recurrent Aphthous Stomatitis by a Probiotic, the Lactobacillus Rhamnosus Lcr35® : a Randomized, Double Blind and Placebo-controlled Trial Active, not recruiting NCT02789605 Phase 2 Bacilor;Placebo
23 Clinical Protocol to Evaluate Use of Topical Pentoxifylline Gel on Behcet's Disease Genital Ulcers Not yet recruiting NCT04186559 Phase 2 Topical Pentoxifylline Gel (Vehicle +PTX);Topical Placebo Gel (Vehicle)
24 Phase 2 Study of Efficacy of Adhesive Tablets in Treating Oral Ulcers (Aphthous) Suspended NCT00281723 Phase 2 Pro-Pe adhesive tablet
25 Evaluation of Efficacy and Mechanisms of Topical Thalidomide for Chronic Graft-Versus-Host-Disease Related Stomatitis Terminated NCT00075023 Phase 2 Thalidomide Gel;Placebo Gel
26 Effects of Probiotic Addition to Corticosteroid Treatment for PFAPA Withdrawn NCT02535962 Phase 2
27 Phase 1 Evaluation of Therapeutic Effect of Chamomilla Tincture Mouthwash on Oral Aphthae Completed NCT01122147 Phase 1 chamomilla tincture mouthwash;placebo mouthwash
28 Phase 1 1 Study Assesing the Benefit of Pasteurized Goat Milk in Reducing Disease Severity of Young Children With Oral Ulcer Diseases Completed NCT00333749 Phase 1
29 Propolis-based Nanovesicles as Oromuco-adhesive Film: Novel Therapeutic Drug Delivery System for Treatment of Oral Recurrent Aphthous Ulcer Completed NCT03615820 Phase 1 Niosomal PPE oromucoadhesive film;Oromucoadhesive film
30 Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Recruiting NCT02775994 Phase 1 Canakinumab
31 Platelet Rich-plasma in Management of Chronic Multiple Oral Ulcers Not yet recruiting NCT03878771 Phase 1 Dermovate cream in Orabase
32 Clinical Evaluation of Topical Coenzyme Q10 in Management of Oral Aphthous Ulcer Unknown status NCT03213769 topical coenzyme Q10 gel;Carpabol gel
33 Characterisation of the Salivary and Faecal Microbiome in Patients With Recurrent Aphthous Stomatitis Before and After Treatment With Probiotics Unknown status NCT02976922
34 The Clinical and Biological Effects Of The Use Of Probiotic VSL#3 In Patients With Oral Lichen Planus : a Proof-of-concept Study Unknown status NCT03052179
35 Oral Vitamin B12 as Potential Treatment of Recurrent Aphthous Stomatitis Completed NCT00288769 daily sublingual tablets Vitamin B12 1000 mcg versus placebo
36 Effects of a Night Guard on Aphthous Stomatitis Completed NCT02890524
37 Treatment of Recurrent Aphthous Stomatitis With Er,Cr:YSGG Laser Irradiation: A Randomized Controlled Clinical Study Completed NCT02925182
38 The Effect of 2-DeNT Oral Topical Powder on Minor Recurrent Aphthous Ulcer Completed NCT02142543 Early Phase 1 2-DeNT powder;Placebo Comparator
39 A Trial of Pentoxifylline for the Treatment of Recurrent Aphthous Stomatitis Completed NCT00315679 Pentoxifylline (also known as oxpentifylline)
40 Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis : a Randomised Clinical Trial Completed NCT01501409
41 Patient Evaluation and Treatment of Oral Soft Tissue Diseases According to Generally Available, Standard Procedures and Therapeutic Modalities Completed NCT00001601
42 Gynaecological Disorders in Patients With Not-celiac Wheat Sensitivity Completed NCT03027492
43 Abdominal Ultrasound Examination in Patients Affected With Non-celiac Wheat Sensitivity Completed NCT03017274
44 Evaluation of Capsule Endoscopy in Patients With Suspected Crohn's Disease Completed NCT00487396
45 Workflow Validation of an In-Home Feedback Controlled Mandibular Positioner Completed NCT03616327
46 Duodenal and Rectal Histology in Non-celiac Wheat Sensitivity and Irritable Bowel Syndrome Patients Completed NCT03022994
47 Effects of Ancient Grains-based Diet in a Closed Community Completed NCT03020511
48 The Serum Eosinophil Cationic Protein Levels in Behçet's Disease and Its Relation to the Clinical Activity Completed NCT01584778
49 Prevalence of Self-reported Gluten Sensitivity in a Population of High-school Students Completed NCT03021148
50 Oral Ulcer Prevalence of and Quality of Life: a Hospital-based Cross-sectional Study Completed NCT03167632

Search NIH Clinical Center for Aphthous Stomatitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Benzocaine
BENZOCAINE PWDR
Levonordefrin
Thalidomide

Cochrane evidence based reviews: stomatitis, aphthous

Sources

Genetic Tests for Aphthous Stomatitis

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Anatomical Context for Aphthous Stomatitis

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MalaCards organs/tissues related to Aphthous Stomatitis:

40
Bone, Tongue, T Cells, B Cells, Thyroid, Kidney, Liver
Sources

Publications for Aphthous Stomatitis

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Articles related to Aphthous Stomatitis:

(show top 50) (show all 1850)
# Title Authors PMID Year
1
Analysis of oral mucosa erosive-ulcerative lesions by reflectance confocal microscopy. 61 42
31538445 2019
2
Topical insulin-liposomal formulation in management of recurrent aphthous ulcers: A randomized placebo-controlled trial. 42
31350870 2019
3
Behcets Syndrome with a Rare Manifestation. 42
31562726 2019
4
Association of salivary S. mutans colonisation and mannose-binding lectin deficiency with gender in Behçet's disease. 54 61
19796530 2009
5
Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome: A debate about diagnosis and treatment in children continues. 61
31866107 2020
6
The immunology of the periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome; what can the tonsils reveal. A literature review. 61
31786522 2020
7
Do Heavy Metals Accumulated in Saliva Involve in the Etiopathogenesis of Recurrent Aphthous Stomatitis? 61
32030633 2020
8
Depression Symptoms and recurrent aphthous stomatitis - evidence from a population-based study in Indonesia. 61
32031742 2020
9
Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis. 61
31846848 2020
10
Behçet's disease with invasive pulmonary aspergillosis and Aspergillus auriculatus infection: A case report. 61
32028403 2020
11
Wound Healing Promoting Activity of Tonsil-Derived Stem Cells on 5-Fluorouracil-Induced Oral Mucositis Model. 61
32002842 2020
12
Serum prolidase and oxidative stress levels in patients with recurrent aphthous stomatitis: a prospective, controlled study. 61
31249217 2020
13
Probiotics for recurrent idiopathic aphthous stomatitis in adults: a placebo-controlled randomized trial. 61
31954066 2020
14
LncRNA CASC 2 is upregulated in aphthous stomatitis and predicts the recurrence. 61
31937279 2020
15
Gene variability in matrix metalloproteinases in patients with recurrent aphthous stomatitis. 61
31968135 2020
16
Association between the promoter region of serotonin transporter polymorphisms and recurrent aphthous stomatitis: A meta-analysis. 61
31550570 2020
17
Validation of the HADS and PSS-10 and a cross-sectional study of psychological status in patients with recurrent aphthous stomatitis. 61
31919894 2020
18
Properties of fucoidans beneficial to oral healthcare. 61
31214896 2020
19
Chitosan oral patches inspired by mussel adhesion. 61
31712088 2020
20
Takayasu's arteritis: associated inflammatory diseases. 61
31969224 2020
21
Salivary levels of IgE and ECP in patients with recurrent aphthous stomatitis. 61
31976038 2020
22
Clinicopathological and Immunological Profile of Patients with Cutaneous Manifestations and their Relationship with Organ Involvement in Systemic Lupus Erythematosus Attending a Tertiary Care Center of Eastern India. 61
32029935 2020
23
Clinical characteristics and survival of 413 patients with systemic lupus erythematosus in southeastern areas of South Korea: A multicenter retrospective cohort study. 61
31802639 2020
24
Celiac disease and hematological abnormalities in children with recurrent aphthous stomatitis. 61
31957941 2020
25
Successful Treatment of Hereditary Folate Malabsorption With Intramuscular Folinic Acid. 61
31371121 2020
26
Chapter 6: Vitamins and Oral Health. 61
31940621 2020
27
Performance of recently proposed periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome criteria in a region endemic for familial Mediterranean fever. 61
31346686 2020
28
Management of Behçet syndrome. 61
31609785 2020
29
Laser therapy for recurrent aphthous stomatitis: an overview. 61
31720851 2020
30
Limited Evidence Suggests That Patients With Recurrent Aphthous Stomatitis May Benefit From Using Sodium Lauryl Sulfate-free Dentifrices. 61
31843182 2019
31
Oral Microbiota Composition and Antimicrobial Antibody Response in Patients with Recurrent Aphthous Stomatitis. 61
31805744 2019
32
[A report of clinical characteristics of 2 Chinese pedigrees with haploinsufficiency of A20 and literature review]. 61
31795558 2019
33
Application of botulinum toxin in maxillofacial field: Part III. Ancillary treatment for maxillofacial surgery and summary. 61
31709199 2019
34
Eugenol allergy mimicking recurrent aphthous stomatitis and burning mouth syndrome. 61
31373017 2019
35
Immune Dysregulation in the Tonsillar Microenvironment of Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis (PFAPA) Syndrome. 61
31807979 2019
36
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). 61
31886897 2019
37
Positioning of apremilast in treatment of Behçet's disease. 61
31747804 2019
38
Phenotypes and genotypes of Chinese adult patients with systemic autoinflammatory diseases. 61
31155445 2019
39
Photobiomodulation in Oral Medicine. 61
31873066 2019
40
[Adrenal hemorrhage in a patient with systemic lupus erythematosus]. 61
31848526 2019
41
Doxycycline: An option in the treatment of ulcerated oral lesions? 61
31400293 2019
42
Complicated intraoral defects: reconstruction using a three-paddle perforator free flap. A case report. 61
31862118 2019
43
Up-regulation of plasma lncRNA CACS15 distinguished early-stage oral squamous cell carcinoma patient. 61
31793142 2019
44
Vitamin D and hematinic deficiencies in patients with recurrent aphthous stomatitis. 61
31680206 2019
45
Severe recurrent aphthous stomatitis treated with adalimumab: A case report in a teenage patient. 61
31588588 2019
46
N-acetylcysteine versus chlorhexidine in treatment of aphthous ulcers: a preliminary clinical trial. 61
31679408 2019
47
Oral ulcer activity assessment with the composite index according to different treatment modalities in Behçet's syndrome: a multicentre study. 61
31856935 2019
48
Use of mammalian target of rapamycin inhibitors in patient with autosomal dominant polycystic kidney disease: an updated meta-analysis. 61
31578673 2019
49
Photobiomodulation Therapy in Oral Medicine: A Guide for the Practitioner with Focus on New Possible Protocols. 61
31589560 2019
50
Lupus enteritis as the sole presenting feature of systemic lupus erythematosus: case report and review of the literature. 61
30191770 2019
Sources

Variations for Aphthous Stomatitis

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Expression for Aphthous Stomatitis

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Search GEO for disease gene expression data for Aphthous Stomatitis.
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Pathways for Aphthous Stomatitis

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Pathways related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.17 TNF TLR4 TLR2 NLRP3 MEFV IL6
2
ERK Signaling 63
Show member pathways
 13.97 TNF IL6 IL4 IL2 IL1B IL1A
3
PEDF Induced Signaling 63
Show member pathways
 13.87 TNF TLR4 IL6 IL4 IL2 IL1RN
4
TGF-Beta Pathway 63
Show member pathways
 13.7 TNF IL6 IL4 IL2 IL1B IL1A
5
Akt Signaling 63
Show member pathways
 13.63 TNF TLR4 TLR2 IL6 IL4 IL2
6
Cytokine Signaling in Immune system 65
Show member pathways
 13.52 TNF IL6 IL4 IL2 IL1RN IL1B
7
PAK Pathway 63
Show member pathways
 13.51 TNF IL6 IL4 IL2 IL1B IL1A
8
IL-2 Pathway 63
Show member pathways
 13.4 TNF TLR4 TLR2 IL4 IL2 IL1B
9
Toll-like Receptor Signaling Pathway 1 36
Show member pathways
 13.34 TNF TLR4 TLR2 NLRP3 IL6 IL2
10
PI3K-Akt signaling pathway 36
Show member pathways
 13.18 TNF TLR4 TLR2 IL6 IL4 IL2
11
Human cytomegalovirus infection 36
Show member pathways
 13.16 TNF TLR4 TLR2 IL6 IL1B HLA-B
12
Allograft rejection 1 36
Show member pathways
 13.07 TNF IL6 IL4 IL2 IL1B IL1A
13
Herpes simplex virus 1 infection 36
12.99 TNF TLR2 IL6 IL1B IFNG HLA-B
14
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 65
Show member pathways
 12.96 TNF TLR4 IL6 IL1B IL18 IFNG
15
NF-KappaB Family Pathway 63
Show member pathways
 12.94 TNF TLR4 TLR2 IL6 IL2 IL1B
16
Th17 cell differentiation 36
Show member pathways
 12.85 TNF TLR4 TLR2 IL6 IL4 IL2
17
Immune response NFAT in immune response 22
Show member pathways
 12.84 TNF IL4 IL2 IL18 IL10 IFNG
18
T cell receptor signaling pathway 36
Show member pathways
 12.84 TNF TLR4 TLR2 IL6 IL4 IL2
19
NF-kappaB Signaling 4
12.81 TNF TLR2 IL4 IL2 IL1RN IL1B
20
Immune response IL-23 signaling pathway 22
Show member pathways
 12.8 TNF IL6 IL2 IL1B IL18 IL10
21
4-1BB Pathway 63
Show member pathways
 12.78 TNF IL1B IL1A IFNG CD40
22
TRAF Pathway 63
Show member pathways
 12.77 TNF TLR4 TLR2 IL1B IL1A CD40
23
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.74 TNF IL4 IL2 IFNG HLA-B HLA-A
24
Shigellosis 36
12.63 TNF TLR4 NLRP3 IL1B IL18 CXCL8
25
IL-17 Family Signaling Pathways 64
Show member pathways
 12.61 TNF TLR2 IL6 IL4 IL1B IFNG
26
Human T-cell leukemia virus 1 infection 36
12.59 TNF IL6 IL2 HLA-B HLA-A CSF2
27
JAK-STAT signaling pathway (KEGG) 36
Show member pathways
 12.56 IL6 IL4 IL2 IL10 IFNG CSF2
28
Toll Comparative Pathway 63
Show member pathways
 12.56 TNF TLR4 IL6 IL1B IL1A IFNG
29
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.55 TNF IL6 IL2 IL18 IL10 CXCL8
30
Pathogenic Escherichia coli infection 36
12.55 TNF TLR4 NLRP3 IL6 IL1B IL18
31
Folate Metabolism 1
Show member pathways
 12.54 TNF IL6 IL4 IL2 IL1B IFNG
32
Toxoplasmosis 36
Show member pathways
 12.54 TNF TLR4 TLR2 IL4 IL1B IL1A
33
NOD-like receptor signaling pathway 36
12.52 TNF TLR4 NLRP3 MEFV IL6 IL1B
34
Tuberculosis 36
12.51 TNF TLR4 TLR2 IL6 IL1B IL1A
35
IL-1 Family Signaling Pathways 64
Show member pathways
 12.5 TNF TLR2 IL6 IL1RN IL1B IL1A
36
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.49 TNF TLR4 TLR2 IL6 IL1A CXCL8
37
Bacterial infections in CF airways 22
Show member pathways
 12.47 TNF TLR4 TLR2 IL6 IL4 IL1B
38
Necroptosis 36
Show member pathways
 12.44 TNF TLR4 NLRP3 IL1B IL1A IFNG
39
C-type lectin receptor signaling pathway 36
Show member pathways
 12.44 TNF NLRP3 IL6 IL2 IL1B IL10
40
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.44 TNF IL6 IL1RN IL1B IL1A IL10
41
Colorectal Cancer Metastasis 63
12.38 TNF TLR4 TLR2 IL6 IFNG
42
Cellular senescence (KEGG) 36
12.36 IL6 IL1A HLA-B HLA-A CXCL8
43
Transcriptional misregulation in cancer 36
12.35 IL6 CXCL8 CSF2 CD40
44
Th1 Differentiation Pathway 64
Show member pathways
 12.29 TNF TLR4 TLR2 IL6 IL2 IL1B
45
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
12.28 TNF IL6 IL4 IL2 IL10 IFNG
46
Interleukin-4 and 13 signaling 65
12.28 TNF IL6 IL4 IL1B IL1A IL18
47
Phagosome 36
12.26 TLR4 TLR2 HLA-B HLA-A
48
Microglia Activation During Neuroinflammation: Overview 64
Show member pathways
 12.25 TNF TLR4 TLR2 IL6 IL4 IL1B
49
MAPK Pathway 70
Show member pathways
 12.24 TLR4 TLR2 IL2 IL1B IL1A
50
IL12-mediated signaling events 1
Show member pathways
 12.24 IL4 IL2 IL1B IL18 IFNG HLA-A
Sources

GO Terms for Aphthous Stomatitis

About this section

Cellular components related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 TNF NLRP3 IL6 IL4 IL2 IL1RN
2 external side of plasma membrane GO:0009897 9.65 TNF TLR4 HLA-B CD40 ACE
3 cell surface GO:0009986 9.63 TNF TLR4 TLR2 HLA-B HLA-A CD40
4 phagocytic vesicle membrane GO:0030670 9.5 TLR2 HLA-B HLA-A
5 extracellular space GO:0005615 9.47 TNF IL6 IL4 IL2 IL1RN IL1B
6 MHC class I protein complex GO:0042612 9.37 HLA-B HLA-A

Biological processes related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.38 TLR4 TLR2 NLRP3 IL6 IL4 IL1RN
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.23 TNF TLR4 TLR2 NLRP3 IL6 IL4
3 immune system process GO:0002376 10.22 TLR4 TLR2 NLRP3 MEFV IL2 HLA-B
4 negative regulation of cell proliferation GO:0008285 10.16 TLR2 IL6 IL1B IL1A IL10 CXCL8
5 positive regulation of gene expression GO:0010628 10.13 TNF TLR4 TLR2 IL6 IL4 IL1B
6 MAPK cascade GO:0000165 10.1 TNF IL2 IL1B IL18 CSF2
7 regulation of immune response GO:0050776 10.07 IL4 HLA-B HLA-A CD40
8 defense response to virus GO:0051607 10.06 NLRP3 IL6 IFNG CD40
9 positive regulation of protein phosphorylation GO:0001934 10.06 TNF IL2 IL1B IFNG CD40
10 response to lipopolysaccharide GO:0032496 10.05 TLR4 TLR2 IL1B IL10
11 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.05 TNF TLR4 IL1RN IL1B IL1A CD40
12 positive regulation of angiogenesis GO:0045766 10.04 IL1B IL1A CXCL8 CD40
13 negative regulation of inflammatory response GO:0050728 10.03 NLRP3 MEFV IL2 IL10
14 positive regulation of DNA-binding transcription factor activity GO:0051091 10.02 TNF IL6 IL1B IL10
15 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.01 TNF TLR4 TLR2 NLRP3 IL6 IL1B
16 defense response to Gram-positive bacterium GO:0050830 10 TNF TLR2 NLRP3 IL6
17 cytokine-mediated signaling pathway GO:0019221 10 TNF IL6 IL4 IL2 IL1RN IL1B
18 positive regulation of JNK cascade GO:0046330 9.99 TNF TLR4 IL1RN IL1B IL1A
19 neutrophil chemotaxis GO:0030593 9.98 IL1RN IL1B IL1A CXCL8
20 response to glucocorticoid GO:0051384 9.96 TNF IL6 IL1RN IL10
21 interferon-gamma-mediated signaling pathway GO:0060333 9.95 IFNG HLA-B HLA-A
22 positive regulation of T cell proliferation GO:0042102 9.95 IL6 IL4 IL2 IL1B
23 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.95 TNF TLR4 TLR2 IL1B IL18
24 positive regulation of inflammatory response GO:0050729 9.95 TNF TLR4 TLR2 IL2 IL1B IL18
25 cellular response to organic cyclic compound GO:0071407 9.94 TNF IL1B IL18
26 regulation of insulin secretion GO:0050796 9.94 TNF IL1B IFNG
27 positive regulation of smooth muscle cell proliferation GO:0048661 9.94 TNF IL6 IL18
28 humoral immune response GO:0006959 9.93 TNF IL6 IFNG
29 positive regulation of nitric oxide biosynthetic process GO:0045429 9.93 TNF TLR4 IL1B IFNG
30 positive regulation of B cell proliferation GO:0030890 9.93 TLR4 IL4 IL2 CD40
31 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.92 TNF IL1B IL1A CSF2
32 positive regulation of interferon-gamma production GO:0032729 9.92 TNF TLR4 IL2 IL1B IL18
33 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.92 TNF IL6 IL4 IL2 IL18 IFNG
34 positive regulation of phagocytosis GO:0050766 9.91 TNF IL1B IFNG
35 positive regulation of interleukin-6 secretion GO:2000778 9.91 TNF TLR4 TLR2 IL1B
36 positive regulation of interleukin-6 production GO:0032755 9.91 TNF TLR4 TLR2 IL6 IL1RN IL1B
37 protein kinase B signaling GO:0043491 9.9 TNF IL1B CD40
38 negative regulation of interleukin-6 production GO:0032715 9.9 TNF TLR4 IL10
39 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.9 IL2 IL1B IL1A
40 positive regulation of interleukin-8 production GO:0032757 9.9 TNF TLR4 TLR2 IL1B
41 cellular response to lipopolysaccharide GO:0071222 9.9 TNF TLR4 NLRP3 IL6 IL1RN IL1B
42 positive regulation of JAK-STAT cascade GO:0046427 9.89 TNF IL6 IL10
43 positive regulation of cytokine secretion GO:0050715 9.89 TNF IL1A IL10
44 positive regulation of vascular endothelial growth factor production GO:0010575 9.89 IL6 IL1B IL1A
45 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.89 HLA-B HLA-A ACE
46 lipopolysaccharide-mediated signaling pathway GO:0031663 9.89 TNF TLR4 TLR2 IL1B IL18
47 microglial cell activation GO:0001774 9.88 TNF TLR2 IFNG
48 negative regulation of neurogenesis GO:0050768 9.88 TNF IL6 IL1B
49 positive regulation of interleukin-12 production GO:0032735 9.88 TLR4 TLR2 IFNG CD40
50 positive regulation of chemokine production GO:0032722 9.86 TNF TLR4 TLR2 IL6

Molecular functions related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.28 TNF TLR4 TLR2 NLRP3 MEFV IL6
2 cytokine activity GO:0005125 9.4 TNF IL6 IL4 IL2 IL1RN IL1B
3 growth factor activity GO:0008083 9.35 IL6 IL4 IL2 IL10 CSF2
4 interleukin-1 receptor binding GO:0005149 9.33 IL1RN IL1B IL1A
5 lipopolysaccharide receptor activity GO:0001875 9.26 TLR4 TLR2
Sources

Sources for Aphthous Stomatitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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