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MCID: APH001
MIFTS: 63

Aphthous Stomatitis

Categories: Oral diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Aphthous Stomatitis

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MalaCards integrated aliases for Aphthous Stomatitis:

Name: Aphthous Stomatitis 12 77 54 15 74
Oral Ulcer 12 56 74
Minor Oral Aphthous Ulceration 74
Stomatitis, Aphthous 45
Aphthous Ulceration 12
Oral Aphthous Ulcer 12
Oral Aphthae 12
Canker Sores 44
Canker Sore 12
Aphtha 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Oral diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:9663
ICD9CM 36 528.2
MeSH 45 D013281
NCIt 51 C62546
SNOMED-CT 69 83312008
Sources

Summaries for Aphthous Stomatitis

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MedlinePlus : 44 Canker sores are small, round sores in your mouth. They can be on the inside of your cheek, under your tongue, or in the back of your throat. They usually have a red edge and a gray center. They can be quite painful. They are not the same as cold sores, which are caused by herpes simplex. Canker sores aren't contagious. They may happen if you have a viral infection. They may also be triggered by stress, food allergies, lack of vitamins and minerals, hormonal changes or menstrual periods. In some cases the cause is unknown. In most cases, the sores go away by themselves. Some ointments, creams or rinses may help with the pain. Avoiding hot, spicy food while you have a canker sore also helps.

MalaCards based summary : Aphthous Stomatitis, also known as oral ulcer, is related to stomatitis and pharyngitis, and has symptoms including enanthema, snoring and oral mucosal blisters. An important gene associated with Aphthous Stomatitis is MEFV (MEFV Innate Immuity Regulator, Pyrin), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Infliximab and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and tongue, and related phenotypes are growth/size/body region and cellular

Disease Ontology : 12 A stomatitis characterized by the repeated formation of benign and non-contagious mouth ulcers.

Wikipedia : 77 Aphthous stomatitis is a common condition characterized by the repeated formation of benign and... more...

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Related Diseases for Aphthous Stomatitis

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Diseases related to Aphthous Stomatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 468)
# Related Disease Score Top Affiliating Genes
1 stomatitis 32.6 IL1B MEFV TNF
2 pharyngitis 31.7 IL1B MEFV SPAG7
3 chronic active epstein-barr virus infection 31.7 IFNG IL10 IL2
4 mouth disease 31.7 IFNG IL10 IL1B IL6 TNF
5 cervical adenitis 31.6 IL1B MEFV NLRP3
6 orofacial granulomatosis 31.5 IFNG IL10 IL4 TNF
7 lichen planus 30.9 IFNG IL4 TNF
8 diversion colitis 30.6 IL1B IL4
9 glossitis 30.5 IL1B IL6 TNF
10 laryngitis 30.5 IL1B IL6 TNF
11 variola major 30.4 IFNG IL2
12 hepatitis a 30.4 IFNG IL10 TNF
13 proliferative glomerulonephritis 30.4 IFNG IL4 IL6
14 ige responsiveness, atopic 30.4 IFNG IL10 IL4
15 periodic fever, familial, autosomal dominant 30.4 MEFV NLRP3 TNF
16 chikungunya 30.4 IL1B IL6 TNF
17 food allergy 30.4 IFNG IL10 IL4
18 pyoderma gangrenosum 30.3 MEFV NLRP3 TNF
19 burning mouth syndrome 30.3 IL2 IL6 TNF
20 smallpox 30.2 IFNG IL2 TNF
21 periodontal disease 30.1 IL1B IL1RN IL6 TNF
22 gingivitis 30.1 IL1B IL4 IL6 TNF
23 familial mediterranean fever 30.0 IL1B IL1RN MEFV NLRP3 TNF
24 pityriasis rosea 30.0 HLA-A HLA-B
25 chronic graft versus host disease 29.7 IFNG IL10 TNF
26 crohn's colitis 29.7 IFNG IL1B IL2 TNF
27 rheumatic heart disease 29.6 HLA-B IL10 IL4 IL6 TNF
28 histoplasmosis 29.5 HLA-A HLA-B IFNG
29 uveitis 29.5 HLA-B IFNG IL10 IL4 TNF
30 erythema multiforme 29.5 IFNG IL2 TNF
31 pulmonary tuberculosis 29.5 IFNG IL10 IL2 IL4 TNF
32 cutaneous t cell lymphoma 29.5 IFNG IL2 IL4
33 arthritis 29.5 IFNG IL10 IL1B IL1RN IL6 TNF
34 human immunodeficiency virus infectious disease 29.3 IFNG IL10 IL2 IL6 TNF
35 colitis 29.2 IFNG IL10 IL1B IL2 IL4 IL6
36 periodontitis 29.2 IFNG IL10 IL1B IL4 IL6 TNF
37 inflammatory bowel disease 29.1 IFNG IL10 IL1B IL2 IL4 IL6
38 intermediate uveitis 29.1 HLA-B IFNG IL10 IL2 IL6 TNF
39 multiple sclerosis 29.1 IFNG IL10 IL1B IL2 IL4 IL6
40 leishmaniasis 29.1 IFNG IL10 IL1B IL4 TNF
41 human herpesvirus 8 29.1 HLA-A HLA-B IL6
42 acquired immunodeficiency syndrome 29.1 HLA-B IFNG IL10 IL1B IL2 IL6
43 severe cutaneous adverse reaction 29.1 HLA-A HLA-B TNF
44 visceral leishmaniasis 28.9 IFNG IL10 IL2 IL4 TNF
45 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 28.8 IFNG IL10 IL2 IL4
46 cytomegalovirus infection 28.5 HLA-A HLA-B IL1B IL6 TNF
47 systemic lupus erythematosus 28.3 IFNG IL10 IL1B IL2 IL4 IL6
48 rheumatoid arthritis 28.2 HLA-B IFNG IL10 IL1B IL1RN IL2
49 behcet syndrome 28.2 HLA-A HLA-B IFNG IL10 IL1B IL1RN
50 graft-versus-host disease 27.5 HLA-A HLA-B IFNG IL10 IL1B IL2

Graphical network of the top 20 diseases related to Aphthous Stomatitis:



Diseases related to Aphthous Stomatitis
Sources

Symptoms & Phenotypes for Aphthous Stomatitis

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UMLS symptoms related to Aphthous Stomatitis:


enanthema, snoring, oral mucosal blisters, halitosis, oral manifestations, sore mouth

MGI Mouse Phenotypes related to Aphthous Stomatitis:

47 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.19 IFNG IL10 IL1B IL1RN IL2 IL4
2 cellular MP:0005384 10.18 IFNG IL10 IL1RN IL2 IL4 IL6
3 hematopoietic system MP:0005397 10.18 IFNG IL10 IL1B IL1RN IL2 IL4
4 homeostasis/metabolism MP:0005376 10.16 IFNG IL10 IL1B IL1RN IL2 IL4
5 immune system MP:0005387 10.13 IFNG IL10 IL1B IL1RN IL2 IL4
6 integument MP:0010771 10.06 IFNG IL10 IL1B IL1RN IL4 IL6
7 digestive/alimentary MP:0005381 10.05 IFNG IL10 IL2 IL4 IL6 NLRP3
8 mortality/aging MP:0010768 10.02 IFNG IL10 IL1B IL1RN IL2 IL4
9 liver/biliary system MP:0005370 9.97 IFNG IL10 IL2 IL4 IL6 MEFV
10 reproductive system MP:0005389 9.81 IFNG IL10 IL1RN IL2 IL4 IL6
11 neoplasm MP:0002006 9.73 IFNG IL10 IL1B IL2 IL6 TNF
12 respiratory system MP:0005388 9.43 IFNG IL10 IL2 IL4 IL6 TNF
13 skeleton MP:0005390 9.28 IFNG IL10 IL1B IL1RN IL4 IL6
Sources

Drugs & Therapeutics for Aphthous Stomatitis

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Drugs for Aphthous Stomatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 349)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4 170277-31-3
2
Chlorhexidine Approved, Vet_approved Phase 4,Phase 2,Phase 3 55-56-1 2713 9552079
3
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 53123-88-9 46835353 5284616 6436030
4
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 104987-11-3 6473866 445643 439492
5
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Not Applicable 24280-93-1 446541
6
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 22916-47-8 4189
7
Everolimus Approved Phase 4,Phase 3,Phase 2,Not Applicable 159351-69-6 70789204 6442177
8
Deferasirox Approved, Investigational Phase 4 201530-41-8 5493381
9
Iron Approved, Experimental Phase 4 7439-89-6, 15438-31-0 27284 23925
10
alemtuzumab Approved, Investigational Phase 4 216503-57-0
11
Vitamin C Approved, Nutraceutical Phase 4,Not Applicable 50-81-7 54670067 5785
12 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
13 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
14 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
15 Vitamins Phase 4,Phase 3,Phase 2,Not Applicable
16 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
17 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
18 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
19 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
20 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
21 Disinfectants Phase 4,Phase 2,Phase 3
22 Anti-Infective Agents, Local Phase 4,Phase 2,Phase 3
23 Aloe Phase 4
24 Chlorhexidine gluconate Phase 4,Phase 2,Phase 3
25 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
26 Antifungal Agents Phase 4,Phase 3,Phase 2,Not Applicable
27 Antineoplastic Agents, Immunological Phase 4,Phase 3,Phase 2
28 Iron Chelating Agents Phase 4
29 Chelating Agents Phase 4,Phase 1,Phase 2
30
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 2,Early Phase 1 1177-87-3
31
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
32
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Early Phase 1 50-02-2 5743
33
Flavin Mononucleotide Approved, Investigational Phase 3 146-17-8 643976
34
Glycerol Approved, Investigational Phase 3 56-81-5 753
35
Hydroxocobalamin Approved Phase 3,Phase 2,Not Applicable 13422-51-0 15589840 11953898
36
Procaine Approved, Investigational, Vet_approved Phase 3,Phase 2 59-46-1 4914
37
leucovorin Approved Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 143 6006
38
Ethanol Approved Phase 3 64-17-5 702
39
Menthol Approved Phase 3 2216-51-5 16666
40
Neomycin Approved, Vet_approved Phase 3 1404-04-2 8378
41
Adalimumab Approved Phase 2, Phase 3,Phase 3 331731-18-1 16219006
42
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
43
Azathioprine Approved Phase 3 446-86-6 2265
44
carbamide peroxide Approved Phase 3 124-43-6
45
Benzydamine Approved Phase 3 642-72-8, 100-46-9 7504
46
Diphenhydramine Approved, Investigational Phase 3,Phase 2,Early Phase 1 147-24-0, 58-73-1 3100
47
Doxepin Approved, Investigational Phase 3 1668-19-5 667468 667477
48
Lidocaine Approved, Vet_approved Phase 3,Phase 1 137-58-6 3676
49
Histamine Approved, Investigational Phase 3,Phase 2,Early Phase 1 51-45-6 774
50
Promethazine Approved, Investigational Phase 3,Phase 2,Early Phase 1 60-87-7 4927

Interventional clinical trials:

(show top 50) (show all 214)
# Name Status NCT ID Phase Drugs
1 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4 infliximab;placebo
2 Aloe Vera and Chlorhexidine Against Traumatic Oral Ulcers Completed NCT03633292 Phase 4 Antiseptic clorhexidine gel (Lacer, Barcelona, Spain);Master formula of aloe vera gel 80%
3 Safety Study of Crushed Deferasirox Film Coated Tablets in Pediatric Patients With Transfusional Hemosiderosis Recruiting NCT03372083 Phase 4 Deferasirox
4 Evaluation of Calcineurin-inhibitor Reduction With Conversion at 2 Months to Everolimus/Reduced Tacrolimus in Renal Transplant Recipients Following Campath® Induction Active, not recruiting NCT01935128 Phase 4 Arm 1 Everolimus/Reduced dose tacrolimus
5 The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus Unknown status NCT01083420 Phase 3 Minocycline;Dexamethasone
6 The Efficacy of Topical Mesalazine Sustained-Release Tablets in Crohn's Disease Patients With Oral Ulcer Unknown status NCT02769494 Phase 3 Mesalazine Sustained-Release Tablets;Riboflavin Sodium Phosphate Injection
7 Diet and Lifestyle Intervention Study in Postpartum Women in China Unknown status NCT01039051 Phase 2, Phase 3
8 Prevention of Recurrent Aphthous Stomatitis Using Vitamins Completed NCT00527306 Phase 3
9 Efficacy of the Combination Bismuth + Neomycin + Procaine in the Treatment of Recurrent Aphthous Ulceration Completed NCT00857688 Phase 3 Bismu-Jet
10 A Study of Adalimumab for the Maintenance of Clinical Remission in Japanese Subjects With Crohn's Disease Completed NCT00445432 Phase 2, Phase 3
11 Efficacy and Safety of Two Treatment Algorithms in Adults With Moderate to Severe Crohn's Disease Completed NCT01235689 Phase 3 Prednisone;Azathioprine
12 Safety & Efficacy Study of Benzydamine Oral Rinse for the Treatment of Oral Mucositis (Mouth Sores) Resulting From Radiation Therapy for Cancer of the Oral Cavity, Oropharynx, or Nasopharynx Completed NCT00051441 Phase 3 Benzydamine Hydrochloride 0.15% Oral Rinse
13 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3 supersaturated calcium phosphate rinse
14 Doxepin and a Topical Rinse in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Radiotherapy With or Without Chemotherapy Completed NCT02229539 Phase 3 doxepin hydrochloride oral solution;DLA (diphenhydramine, lidocaine and antacids) rinse
15 A Study of Atezolizumab Compared With Docetaxel in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Failed Platinum-Containing Therapy Completed NCT02008227 Phase 3 Atezolizumab;Docetaxel
16 STRIVE (Sierra Leone Trial to Introduce a Vaccine Against Ebola) Completed NCT02378753 Phase 2, Phase 3
17 Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer Completed NCT00101582 Phase 3 Placebo;palifermin;cisplatin chemotherapy
18 Paclitaxel Compared With Doxorubicin in Treating Patients With Advanced AIDS-Related Kaposi's Sarcoma Completed NCT00003350 Phase 3 paclitaxel;pegylated liposomal doxorubicin hydrochloride
19 Alectinib Versus Pemetrexed or Docetaxel in Anaplastic Lymphoma Kinase (ALK)-Positive Advanced Non-Small Cell Lung Cancer (NSCLC) Participants Previously Treated With Platinum-Based Chemotherapy and Crizotinib Completed NCT02604342 Phase 3 Alectinib;Docetaxel;Pemetrexed
20 A Clinical Trial Testing The Efficacy Of Crizotinib Versus Standard Chemotherapy Pemetrexed Plus Cisplatin Or Carboplatin In Patients With ALK Positive Non Squamous Cancer Of The Lung Completed NCT01154140 Phase 3 treatment;treatment
21 ARCHER 1009 : A Study Of Dacomitinib (PF-00299804) Vs. Erlotinib In The Treatment Of Advanced Non-Small Cell Lung Cancer Completed NCT01360554 Phase 3 Dacomitinib (PF-00299804);Active Comparator (erlotinib);Placebo erlotinib;Placebo PF00299804
22 Study Of The Effectiveness & Safety Of Lenalidomide Versus Chlorambucil As First Line Therapy For Elderly Patients With B-Cell CLL (The ORIGIN Trial) Completed NCT00910910 Phase 3 Lenalidomide;Chlorambucil
23 A Study of Adalimumab in Japanese Subjects With Intestinal Behçet's Disease Completed NCT01243671 Phase 3
24 An Investigational Drug, PF-02341066 Is Being Studied Versus Standard Of Care In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene Completed NCT00932893 Phase 3 PF-02341066;Pemetrexed;Docetaxel
25 AVAPERL1 Study: A Study of Avastin (Bevacizumab) With or Without Pemetrexed as Maintenance Therapy After Avastin in First Line in Patients With Non-Squamous Non-Small Cell Lung Cancer Completed NCT00961415 Phase 3 bevacizumab [Avastin];cisplatin;pemetrexed
26 Tacrolimus/Everolimus vs. Tacrolimus/MMF in Pediatric Heart Transplant Recipients Using the MATE Score Recruiting NCT03386539 Phase 3 Everolimus;Tacrolimus;Mycophenolate Mofetil
27 A Study Evaluating the Efficacy and Safety of Tislelizumab Versus Chemotherapy in Advanced Non-Squamous NSCLC Recruiting NCT03663205 Phase 3 Tislelizumab,Cisplatin or carboplatin ,Pemetrexed;Cisplatin or carboplatin,Pemetrexed
28 Caries Prevention and Side Effects of Gum Arabic and Licorice Extracts Versus Chlorhexidine in High Caries Risk Patients Recruiting NCT03684993 Phase 2, Phase 3 Arabic, Gum;Licorice Root;Chlorhexidine
29 Dexamethasone in Reducing Everolimus-Induced Oral Stomatitis in Patients With Cancer Recruiting NCT03839940 Phase 3 Dexamethasone;Everolimus
30 A Study to Investigate the Effects of GC4419 on Radiation Induced Oral Mucositis in Patients With Head/Neck Cancer Recruiting NCT03689712 Phase 3 GC4419;Placebo
31 An Efficacy Study Comparing Brigatinib Versus Alectinib in Advanced Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer Participants Who Have Progressed on Crizotinib Recruiting NCT03596866 Phase 3 Brigatinib;Alectinib
32 A Phase 3 Randomized, Double-blind Study to Evaluate the Efficacy and Safety of Apremilast (CC-10004) in Subjects With Active Behcet's Disease Active, not recruiting NCT02307513 Phase 3 Apremilast (CC-10004);Placebo
33 Weekly Cetuximab/RT Versus Weekly Cisplatin/RT in HPV-Associated Oropharyngeal Squamous Cell Carcinoma Active, not recruiting NCT01855451 Phase 3 Cetuximab;Cisplatin
34 A Study Comparing Alectinib With Crizotinib in Treatment-Naive Anaplastic Lymphoma Kinase-Positive Advanced Non-Small Cell Lung Cancer Participants Active, not recruiting NCT02075840 Phase 3 Alectinib;Crizotinib
35 A Study Of Crizotinib Versus Chemotherapy In Previously Untreated ALK Positive East Asian Non-Small Cell Lung Cancer Patients Active, not recruiting NCT01639001 Phase 3 Crizotinib;Pemetrexed/Cisplatin;Pemetrexed/Carboplatin
36 Avelumab in Non-Small Cell Lung Cancer (JAVELIN Lung 200) Active, not recruiting NCT02395172 Phase 3 Avelumab;Docetaxel
37 AZD9291 Versus Gefitinib or Erlotinib in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer Active, not recruiting NCT02296125 Phase 3 AZD9291 80 mg/40 mg + placebo;Placebo Erlotinib 150/100mg;Placebo Gefitinib 250 mg;Erlotinib 150/100 mg;Gefitinib 250 mg;Placebo AZD9291 80 mg/ 40 mg
38 A Global Study to Assess the Effects of MEDI4736 Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer Active, not recruiting NCT02125461 Phase 3 MEDI4736
39 Avelumab in First-line Non-Small Cell Lung Cancer (JAVELIN Lung 100) Active, not recruiting NCT02576574 Phase 3 Avelumab;Pemetrexed;Paclitaxel;Gemcitabine;Gemcitabine;Carboplatin;Cisplatin;Carboplatin;Avelumab
40 A Study of Pembrolizumab (MK-3475) in Combination With Etoposide/Platinum (Cisplatin or Carboplatin) for Participants With Extensive Stage Small Cell Lung Cancer (MK-3475-604/KEYNOTE-604) Active, not recruiting NCT03066778 Phase 3 Normal saline solution;Carboplatin;Cisplatin;Etoposide
41 Herbal Treatment to Improve Chemotherapy Delivery Not yet recruiting NCT03716518 Phase 3 Tonifying Spleen and Kidney Sequential Regimen;Placebo of 'Tonifying Spleen and Kidney Sequential Regimen
42 A Study to Investigate the Safety and Efficacy of Atezolizumab in Previously-Treated Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Not yet recruiting NCT03922997 Phase 3 Atezolizumab
43 Alflutinib Mesylate Versus Gefitinib in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer （FLAG） Not yet recruiting NCT03787992 Phase 3 Alflutinib Mesylate (AST2818) 80mg//40 mg+ placebo;Placebo Gefitinib 250 mg;Gefitinib 250 mg;Placebo AST2818 80mg//40 mg
44 Palifermin in Lessening Oral Mucositis in Patients Undergoing Radiation Therapy and Chemotherapy for Locally Advanced Head and Neck Cancer Terminated NCT00360971 Phase 3 cisplatin
45 Caphosol Study: Prevention of Oral Mucositis in Children, Adolescents and Young Adults Receiving Chemotherapy Terminated NCT02539342 Phase 3 Caphosol;Biotene
46 Carboplatin And Paclitaxel With Or Without CP-751, 871 (An IGF-1R Inhibitor) For Advanced NSCLC Of Squamous, Large Cell And Adenosquamous Carcinoma Histology Terminated NCT00596830 Phase 3 CP-751,871 (Figitumumab);Carboplatin;Paclitaxel;Carboplatin;Paclitaxel
47 Trial Of CP-751, 871 And Erlotinib In Refractory Lung Cancer Terminated NCT00673049 Phase 3 CP 751,871 (Figitumumab);Erlotinib;Erlotinib
48 A Study of ASP8273 vs. Erlotinib or Gefitinib in First-line Treatment of Patients With Stage IIIB/IV Non-small Cell Lung Cancer Tumors With EGFR Activating Mutations Terminated NCT02588261 Phase 3 naquotinib mesilate;Erlotinib;Gefitinib
49 CD2 Lozenges in Preventing Acute Oral Mucositis in Patients With Head and Neck Cancer Receiving Radiotherapy and Chemotherapy Withdrawn NCT01545687 Phase 3
50 Omega-3 and Quality of Life in Recurrent Aphthous Stomatitis Patients Unknown status NCT01831453 Phase 2 omega-3;placebo

Search NIH Clinical Center for Aphthous Stomatitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: stomatitis, aphthous

Sources

Genetic Tests for Aphthous Stomatitis

About this section
Sources

Anatomical Context for Aphthous Stomatitis

About this section

MalaCards organs/tissues related to Aphthous Stomatitis:

42
Lung, Bone, Tongue, Kidney, Testes, Breast, Bone Marrow
Sources

Publications for Aphthous Stomatitis

About this section

Articles related to Aphthous Stomatitis:

(show top 50) (show all 760)
# Title Authors Year
1
Severe HIV-associated aphthous stomatitis treated with etanercept. ( 30528070 )
2019
2
Serum levels of total antioxidant status, nitric oxide and nitric oxide synthase in minor recurrent aphthous stomatitis patients. ( 30653111 )
2019
3
Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome - PFAPA syndrome. ( 30683466 )
2019
4
Immunogenicity and side-effects of the inactivated hepatitis A vaccine in periodic fever, aphthous stomatitis, pharyngitis, and adenitis patients. ( 30734430 )
2019
5
Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome: main features and an algorithm for clinical practice. ( 30798384 )
2019
6
Azithromycin-induced aphthous stomatitis: a case series. ( 30827258 )
2019
7
Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis: A Systematic Review. ( 30839136 )
2019
8
Mediterranean fever gene variants and colchicine therapy in periodic fever, aphthous stomatitis pharyngitis, adenitis syndrome in a Mediterranean region. ( 30887853 )
2019
9
Towards better diagnostic criteria for PFAPA (periodic fever, aphthous stomatitis, pharyngitis and adenitis) syndrome. ( 30901126 )
2019
10
Diagnostic Value of Neutrophil-Lymphocyte Ratios and Mean Platelet Volumes in the Activation of Recurrent Aphthous Stomatitis. ( 30906727 )
2019
11
Beta-defensin 1 gene polymorphisms at 5' untranslated region are not associated with a susceptibility to recurrent aphthous stomatitis. ( 30928860 )
2019
12
Periodic Fever with Pharyngitis, Aphthous Stomatitis and Cervical Adenitis Syndrome: A Rare Cause of Fever in Adults. ( 30931275 )
2019
13
Adhesive alginate for buccal delivery in aphthous stomatitis. ( 30974304 )
2019
14
Recurrent Aphthous Stomatitis Caused by Cytomegalovirus, Herpes Simplex Virus, and Candida Species in a Kidney Transplant Recipient: A Case Report. ( 30979493 )
2019
15
Recurrence of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome after tonsillectomy: case-based review. ( 31020337 )
2019
16
Rare missense variants in the ALPK1 gene may predispose to periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome. ( 31053777 )
2019
17
Association between interleukin family gene polymorphisms and recurrent aphthous stomatitis risk. ( 29550839 )
2019
18
Familial Mediterranean fever and periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: shared features and main differences. ( 30019226 )
2019
19
Patients who seek professional treatment of recurrent aphthous stomatitis probably have an increased risk of having head and neck cancer and other types of cancers. ( 30340756 )
2019
20
Comorbidity profiles among patients with recurrent aphthous stomatitis: A case-control study. ( 30348492 )
2019
21
Familial Mediterranean Fever Is Commonly Diagnosed in Children in Israel with Periodic Fever Aphthous Stomatitis, Pharyngitis, and Adenitis Syndrome. ( 30361059 )
2019
22
Treatment options for periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome in children and adults: a narrative review. ( 30488366 )
2019
23
Extensive oral ulcer in a patient with lupus erythematosus. ( 31090856 )
2019
24
Effect of Shuangjinlian mixture on oral ulcer model in rat. ( 31049005 )
2019
25
The Effect of Using Bone Marrow Mesenchymal Stem Cells Versus Platelet Rich Plasma on the Healing of Induced Oral Ulcer in Albino Rats. ( 30836730 )
2019
26
Polysaccharides from tubers of Bletilla striata: Physicochemical characterization, formulation of buccoadhesive wafers and preliminary study on treating oral ulcer. ( 30227203 )
2019
27
Psychometric analysis of stress, anxiety and depression in patients with recurrent aphthous Stomatitis-A cross-sectional survey based study. ( 30607229 )
2018
28
Association Between Anxiety, Depression, and Salivary Cortisol Levels in Patients with Recurrent Aphthous Stomatitis. ( 30319874 )
2018
29
Chinese herbal medicine for recurrent aphthous stomatitis: a protocol for systematic review and meta-analysis. ( 30558077 )
2018
30
Comparing Serum and Salivary Levels of Vitamin D in Patients with Recurrent Aphthous Stomatitis and Healthy Individuals. ( 30680302 )
2018
31
Design, Development and In vitro/Ex vivo Evaluation of Mucoadhesive Buccal Film of Benzydamine Hydrochloride for the Effective Treatment of Aphthous Stomatitis. ( 30706830 )
2018
32
Evaluation of salivary tumour necrosis factor-alpha in patients with recurrent aphthous stomatitis. ( 30775720 )
2018
33
Unique histologic features of tonsils from patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 28748511 )
2018
34
The First International Conference on Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis Syndrome. ( 29246466 )
2018
35
Association of Serotonin Transporter Gene Polymorphism with Recurrent Aphthous Stomatitis. ( 29296268 )
2018
36
Healthy lifestyle habits benefit remission of recurrent aphthous stomatitis and RAS type ulceration. ( 29327722 )
2018
37
Examination of serum hematinics and autoantibodies is important for treatment of recurrent aphthous stomatitis. ( 29336939 )
2018
38
Association of the NOD-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population. ( 29430721 )
2018
39
Autosomal dominant deficiency of the interleukin-17F in recurrent aphthous stomatitis: Possible novel mutation in a new entity. ( 29458167 )
2018
40
Hematinic deficiencies in patients with recurrent aphthous stomatitis: variations by gender and age. ( 29476670 )
2018
41
The role of tonsillectomy in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome; a literature review. ( 29483843 )
2018
42
Haematinic deficiencies and patient clinical profiles in Polish patients with recurrent aphthous stomatitis (RAS). ( 29499093 )
2018
43
Relationship between salivary calprotectin levels and recurrent aphthous stomatitis: A preliminary study. ( 29519972 )
2018
44
Comorbidity of PFAPA (periodic fever, aphthous stomatitis, pharyngitis and adenitis) patients: a case control study. ( 29533751 )
2018
45
Chitosan/pvp-based mucoadhesive membranes as a promising delivery system of betamethasone-17-valerate for aphthous stomatitis. ( 29628256 )
2018
46
Associations of IL-1, 6, and 10 Gene Polymorphisms with Susceptibility to Recurrent Aphthous Stomatitis: Insights from a Meta-Analysis. ( 29641282 )
2018
47
The association between minor recurrent aphthous stomatitis (RAS), children's poor oral condition, and underlying negative psychosocial habits and attitudes towards oral hygiene. ( 29653566 )
2018
48
Analysis of Dietary Related Factors of Recurrent Aphthous Stomatitis among College Students. ( 29681971 )
2018
49
Salivary levels of TNF-α in patients with recurrent aphthous stomatitis: A cross-sectional study. ( 29732020 )
2018
50
Gastric parietal cell and thyroid autoantibodies in recurrent aphthous stomatitis patients with concomitant oral lichen planus. ( 29753458 )
2018
Sources

Variations for Aphthous Stomatitis

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Expression for Aphthous Stomatitis

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Search GEO for disease gene expression data for Aphthous Stomatitis.
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Pathways for Aphthous Stomatitis

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Pathways related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 14 HLA-A HLA-B IFNG IL10 IL1B IL1RN
2
PEDF Induced Signaling 65
Show member pathways
 13.67 IFNG IL10 IL1B IL1RN IL2 IL4
3
TGF-Beta Pathway 65
Show member pathways
 13.52 IFNG IL10 IL1B IL2 IL4 IL6
4
Akt Signaling 65
Show member pathways
 13.37 IL10 IL1B IL2 IL4 IL6 TNF
5
Cytokine Signaling in Immune system 67
Show member pathways
 13.33 HLA-A HLA-B IFNG IL10 IL1B IL1RN
6
PAK Pathway 65
Show member pathways
 13.28 IL10 IL1B IL2 IL4 IL6 TNF
7
Toll-like Receptor Signaling Pathway 1 38
Show member pathways
 13.14 IFNG IL10 IL1B IL2 IL6 MEFV
8
PI3K-Akt signaling pathway 38
Show member pathways
 13.03 HLA-A HLA-B IL2 IL4 IL6 TNF
9
Human cytomegalovirus infection 38
Show member pathways
 12.94 HLA-A HLA-B IL1B IL6 TNF
10
Allograft rejection 38 1
Show member pathways
 12.8 HLA-A HLA-B IFNG IL10 IL1B IL2
11
NF-KappaB Family Pathway 65
Show member pathways
 12.68 IL1B IL2 IL6 TNF
12
Immune response NFAT in immune response 23
Show member pathways
 12.68 IFNG IL10 IL2 IL4 TNF
13
Immune response IL-23 signaling pathway 23
Show member pathways
 12.67 IFNG IL10 IL1B IL2 IL6 TNF
14
Th17 cell differentiation 38
Show member pathways
 12.66 IFNG IL10 IL1B IL2 IL4 IL6
15
NF-kappaB Signaling 4
12.62 IFNG IL10 IL1B IL1RN IL2 IL4
16
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 12.6 HLA-A HLA-B IFNG IL2 IL4 TNF
17
T cell receptor signaling pathway 38
Show member pathways
 12.58 IFNG IL10 IL1B IL2 IL4 IL6
18
JAK-STAT signaling pathway (KEGG) 66
Show member pathways
 12.47 IFNG IL10 IL2 IL4 IL6
19
Human T-cell leukemia virus 1 infection 38
12.44 HLA-A HLA-B IL2 IL6 TNF
20
IL-17 Family Signaling Pathways 66
Show member pathways
 12.42 IFNG IL1B IL4 IL6 TNF
21
Selenium Micronutrient Network 1
Show member pathways
 12.42 IFNG IL1B IL2 IL4 IL6 TNF
22
Toxoplasmosis 38
Show member pathways
 12.36 IFNG IL10 IL1B IL4 TNF
23
Toll Comparative Pathway 65
Show member pathways
 12.33 IFNG IL1B IL6 TNF
24
Tuberculosis 38
12.33 IFNG IL10 IL1B IL6 TNF
25
C-type lectin receptor signaling pathway 38
Show member pathways
 12.3 IL10 IL1B IL2 IL6 NLRP3 TNF
26
Bacterial infections in CF airways 23
Show member pathways
 12.29 IFNG IL1B IL4 IL6 TNF
27
IL-1 Family Signaling Pathways 66
Show member pathways
 12.28 IL1B IL1RN IL6 TNF
28
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.28 IL10 IL1B IL1RN IL6 TNF
29
Necroptosis 38
Show member pathways
 12.27 IFNG IL1B NLRP3 TNF
30
Immune response IFN gamma signaling pathway 23
Show member pathways
 12.17 IFNG IL10 IL1B IL2 IL4 IL6
31
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 12.14 IFNG IL1B IL4 IL6 TNF
32
Th1 Differentiation Pathway 66
Show member pathways
 12.13 IFNG IL10 IL1B IL2 IL6 TNF
33
Interleukin-4 and 13 signaling 67
12.09 IL10 IL1B IL4 IL6 TNF
34
IL12-mediated signaling events 1
Show member pathways
 12.08 HLA-A IFNG IL1B IL2 IL4
35
Fluid shear stress and atherosclerosis 38
12.07 IFNG IL1B TNF
36
Spinal Cord Injury 1
12.07 IFNG IL1B IL2 IL4 IL6 TNF
37
Osteoclast differentiation 38
12.03 IFNG IL1B TNF
38
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
12.02 IFNG IL10 IL2 IL4 IL6 TNF
39
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.02 HLA-A HLA-B IFNG IL10 IL1B IL2
40
Amoebiasis 38
12 IFNG IL10 IL1B IL6 TNF
41
Hematopoietic cell lineage 38
11.99 IL1B IL4 IL6 TNF
42
TNF signaling pathway 38
11.96 IL1B IL6 TNF
43
Jak-Stat Signaling Pathway (sino) 68
11.96 IFNG IL10 IL2 IL6
44
Rheumatoid arthritis 38
11.96 IFNG IL1B IL6 TNF
45
Senescence and Autophagy in Cancer 1
11.94 IFNG IL1B IL6
46
AGE-RAGE signaling pathway in diabetic complications 38
11.92 IL1B IL6 TNF
47
Glucocorticoid receptor regulatory network 1
11.91 IFNG IL2 IL4 IL6
48
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.88 IFNG IL2 IL4 TNF
49
Pertussis 38
11.88 IL10 IL1B IL6 NLRP3 TNF
50
Salmonella infection (KEGG) 38
11.85 IFNG IL1B IL6
Sources

GO Terms for Aphthous Stomatitis

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Cellular components related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 IFNG IL10 IL1B IL1RN IL2 IL4
2 extracellular region GO:0005576 9.28 IFNG IL10 IL1B IL1RN IL2 IL4
3 MHC class I protein complex GO:0042612 9.16 HLA-A HLA-B

Biological processes related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.99 IL10 IL2 IL4 IL6
2 positive regulation of protein phosphorylation GO:0001934 9.93 IFNG IL1B IL2 TNF
3 inflammatory response GO:0006954 9.91 IL10 IL1B IL1RN IL6 MEFV NLRP3
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.9 IL1B IL6 NLRP3 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.89 IL6 NLRP3 TNF
6 positive regulation of JNK cascade GO:0046330 9.89 IL1B IL1RN TNF
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.87 IL10 IL1B IL6 TNF
8 interferon-gamma-mediated signaling pathway GO:0060333 9.86 HLA-A HLA-B IFNG
9 negative regulation of inflammatory response GO:0050728 9.86 IL10 IL2 MEFV NLRP3
10 regulation of insulin secretion GO:0050796 9.85 IFNG IL1B TNF
11 humoral immune response GO:0006959 9.84 IFNG IL6 TNF
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.81 IFNG IL2 IL4 IL6
13 positive regulation of interferon-gamma production GO:0032729 9.8 IL1B IL2 TNF
14 positive regulation of T cell proliferation GO:0042102 9.8 IL1B IL2 IL4 IL6
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.79 IFNG IL1B TNF
16 positive regulation of interleukin-6 production GO:0032755 9.78 IL1B IL1RN IL6 TNF
17 negative regulation of neurogenesis GO:0050768 9.75 IL1B IL6 TNF
18 positive regulation of osteoclast differentiation GO:0045672 9.73 IFNG TNF
19 positive regulation of chemokine production GO:0032722 9.73 IL6 TNF
20 positive regulation of T cell differentiation GO:0045582 9.73 IL2 IL4
21 negative regulation of lipid catabolic process GO:0050995 9.73 IL1B TNF
22 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.73 IL1B TNF
23 cellular response to lipopolysaccharide GO:0071222 9.73 IL10 IL1B IL1RN IL6 NLRP3 TNF
24 regulation of regulatory T cell differentiation GO:0045589 9.72 IFNG IL2
25 negative regulation of growth of symbiont in host GO:0044130 9.72 IL10 TNF
26 negative regulation of interleukin-12 production GO:0032695 9.72 IL10 MEFV
27 positive regulation of immunoglobulin secretion GO:0051024 9.72 IL2 IL6
28 positive regulation of glial cell proliferation GO:0060252 9.72 IL1B IL6 TNF
29 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.71 IL10 IL1RN
30 positive regulation of isotype switching to IgG isotypes GO:0048304 9.71 IL2 IL4
31 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.71 HLA-A HLA-B
32 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IFNG IL1B TNF
33 negative regulation of lipid storage GO:0010888 9.7 IL6 TNF
34 positive regulation of interleukin-13 production GO:0032736 9.7 IL4 NLRP3
35 endothelial cell apoptotic process GO:0072577 9.7 IL10 TNF
36 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 IL10 IL1B TNF
37 cytokine-mediated signaling pathway GO:0019221 9.7 IL10 IL1B IL1RN IL2 IL4 IL6
38 positive regulation of chemokine biosynthetic process GO:0045080 9.69 IL1B TNF
39 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.68 HLA-A HLA-B
40 positive regulation of MHC class II biosynthetic process GO:0045348 9.68 IL10 IL4
41 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
42 negative regulation of cytokine secretion involved in immune response GO:0002740 9.67 IL10 TNF
43 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.67 IL6 NLRP3
44 interleukin-1 beta production GO:0032611 9.66 IL1B NLRP3
45 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.66 IL1RN IL6
46 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
47 protection from natural killer cell mediated cytotoxicity GO:0042270 9.65 HLA-A HLA-B
48 regulation of isotype switching GO:0045191 9.65 IL10 IL4
49 sequestering of triglyceride GO:0030730 9.64 IL1B TNF
50 type 2 immune response GO:0042092 9.64 IL10 IL4

Molecular functions related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 IL10 IL2 IL4 IL6
2 cytokine activity GO:0005125 9.23 IFNG IL10 IL1B IL1RN IL2 IL4
3 interleukin-1 receptor binding GO:0005149 9.16 IL1B IL1RN
Sources

Sources for Aphthous Stomatitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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