MCID: APH001
MIFTS: 64

Aphthous Stomatitis

Categories: Oral diseases, Rare diseases

Aliases & Classifications for Aphthous Stomatitis

MalaCards integrated aliases for Aphthous Stomatitis:

Name: Aphthous Stomatitis 12 76 53 15 73
Oral Ulcer 12 29 55 73
Minor Oral Aphthous Ulceration 73
Stomatitis, Aphthous 44
Aphthous Ulceration 12
Oral Aphthous Ulcer 12
Oral Aphthae 12
Canker Sores 43
Canker Sore 12
Aphtha 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9663
ICD9CM 35 528.2
MeSH 44 D013281
NCIt 50 C62546
SNOMED-CT 68 83312008

Summaries for Aphthous Stomatitis

MedlinePlus : 43 Canker sores are small, round sores in your mouth. They can be on the inside of your cheek, under your tongue, or in the back of your throat. They usually have a red edge and a gray center. They can be quite painful. They are not the same as cold sores, which are caused by herpes simplex. Canker sores aren't contagious. They may happen if you have a viral infection. They may also be triggered by stress, food allergies, lack of vitamins and minerals, hormonal changes or menstrual periods. In some cases the cause is unknown. In most cases, the sores go away by themselves. Some ointments, creams or rinses may help with the pain. Avoiding hot, spicy food while you have a canker sore also helps.

MalaCards based summary : Aphthous Stomatitis, also known as oral ulcer, is related to stomatitis and mouth disease, and has symptoms including enanthema, oral mucosal blisters and snoring. An important gene associated with Aphthous Stomatitis is MEFV (MEFV, Pyrin Innate Immunity Regulator), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Infliximab and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include tongue, bone and heart, and related phenotypes are growth/size/body region and cellular

Disease Ontology : 12 A stomatitis characterized by the repeated formation of benign and non-contagious mouth ulcers.

Wikipedia : 76 Aphthous stomatitis is a common condition characterized by the repeated formation of benign and... more...

Related Diseases for Aphthous Stomatitis

Diseases related to Aphthous Stomatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 438)
# Related Disease Score Top Affiliating Genes
1 stomatitis 32.4 IL1B MEFV TNF
2 mouth disease 31.9 IL10 IL1B IL6 TNF
3 orofacial granulomatosis 31.7 IL10 IL4 TNF
4 pharyngitis 31.7 IL1B MEFV SPAG7
5 cervical adenitis 31.4 IL1B MEFV NLRP3
6 celiac disease 1 30.3 HLA-A IL10 IL2 TNF
7 diversion colitis 30.3 IL1B IL4
8 pyoderma gangrenosum 30.2 MEFV NLRP3 TNF
9 glossitis 30.2 IL1B IL6 TNF
10 laryngitis 30.2 IL1B IL6 TNF
11 familial mediterranean fever 30.2 IL1B IL1RN MEFV NLRP3 TNF
12 chikungunya 30.2 IL1B IL6 TNF
13 pityriasis rosea 30.1 HLA-A HLA-B
14 periodic fever, familial, autosomal dominant 30.0 MEFV NLRP3 TNF
15 uveitis 30.0 HLA-B IL10 IL4 TNF
16 arthritis 29.9 IL10 IL1B IL1RN IL6 TNF
17 gingivitis 29.8 IL1B IL4 IL6 TLR2 TNF
18 rheumatic heart disease 29.8 HLA-B IL10 IL4 IL6 TNF
19 chronic graft versus host disease 29.8 IL10 TNF
20 burning mouth syndrome 29.8 IL2 IL6 TNF
21 periodontal disease 29.8 IL1B IL1RN IL6 TLR2 TNF
22 neurosyphilis 29.6 IL10 TLR2
23 crohn's colitis 29.6 IL1B IL2 TNF
24 intermediate uveitis 29.5 HLA-B IL10 IL2 IL6 TNF
25 colitis 29.5 IL10 IL1B IL2 IL4 IL6 TNF
26 viral infectious disease 29.5 IL10 IL1B IL2 IL4 IL6 TNF
27 human immunodeficiency virus infectious disease 29.5 IL10 IL2 IL6 TNF
28 multiple sclerosis 29.4 IL10 IL1B IL2 IL4 IL6 TNF
29 pulmonary tuberculosis 29.4 IL10 IL2 IL4 TLR2 TNF
30 severe cutaneous adverse reaction 29.3 HLA-A HLA-B TNF
31 periodontitis 29.2 IL10 IL1B IL4 IL6 TLR2 TNF
32 human herpesvirus 8 29.1 HLA-A HLA-B IL6
33 visceral leishmaniasis 28.8 IL10 IL2 IL4 TLR2 TNF
34 acquired immunodeficiency syndrome 28.7 HLA-B IL10 IL1B IL2 IL6 TNF
35 rheumatoid arthritis 28.7 HLA-B IL10 IL1B IL1RN IL2 IL4
36 inflammatory bowel disease 28.7 HLA-B IL10 IL1B IL1RN IL2 IL4
37 behcet syndrome 28.6 HLA-A HLA-B IL10 IL1B IL1RN IL2
38 leishmaniasis 28.5 IL10 IL1B IL2 IL4 IL6 TLR2
39 systemic lupus erythematosus 28.4 IL10 IL1B IL2 IL4 IL6 TLR2
40 graft-versus-host disease 28.4 HLA-A HLA-B IL10 IL1B IL2 IL6
41 periodic fever, aphthous stomatitis, pharyngitis and adenitis 12.8
42 sutton disease 2 12.4
43 ulcerative stomatitis 11.3
44 immunodeficiency 12 11.2
45 acatalasemia 11.0
46 chronic active epstein-barr virus infection 11.0
47 anxiety 10.5
48 lichen planus 10.4
49 oral lichen planus 10.4
50 recurrent corneal erosion 10.3 IL1B IL6

Graphical network of the top 20 diseases related to Aphthous Stomatitis:



Diseases related to Aphthous Stomatitis

Symptoms & Phenotypes for Aphthous Stomatitis

UMLS symptoms related to Aphthous Stomatitis:


enanthema, oral mucosal blisters, snoring, halitosis, oral manifestations, sore mouth

MGI Mouse Phenotypes related to Aphthous Stomatitis:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.19 IL10 IL1B IL1RN IL2 IL4 IL6
2 cellular MP:0005384 10.18 IL10 IL1RN IL2 IL4 IL6 MEFV
3 hematopoietic system MP:0005397 10.18 IL10 IL1B IL1RN IL2 IL4 IL6
4 homeostasis/metabolism MP:0005376 10.16 IL10 IL1B IL1RN IL2 IL4 IL6
5 immune system MP:0005387 10.13 IL10 IL1B IL1RN IL2 IL4 IL6
6 integument MP:0010771 10.06 IL10 IL1B IL1RN IL4 IL6 MEFV
7 digestive/alimentary MP:0005381 10.05 IL10 IL2 IL4 IL6 NLRP3 TLR2
8 mortality/aging MP:0010768 10.02 IL10 IL1B IL1RN IL2 IL4 IL6
9 liver/biliary system MP:0005370 9.97 IL10 IL2 IL4 IL6 MEFV NLRP3
10 reproductive system MP:0005389 9.76 IL10 IL1RN IL2 IL4 IL6 MEFV
11 neoplasm MP:0002006 9.73 IL10 IL1B IL2 IL6 TLR2 TNF
12 respiratory system MP:0005388 9.43 IL10 IL2 IL4 IL6 TLR2 TNF
13 skeleton MP:0005390 9.28 IL10 IL1B IL1RN IL4 IL6 MEFV

Drugs & Therapeutics for Aphthous Stomatitis

Drugs for Aphthous Stomatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 148)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4 170277-31-3
2 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
3 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
4 Dermatologic Agents Phase 4,Phase 2,Early Phase 1
5
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
6
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Early Phase 1 50-02-2 5743
7
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Early Phase 1 1177-87-3
8
Hydroxocobalamin Approved Phase 3,Not Applicable 13422-51-0 11953898 44475014
9
Ethanol Approved Phase 3 64-17-5 702
10
Menthol Approved Phase 3 2216-51-5 16666
11
Neomycin Approved, Vet_approved Phase 3 1404-04-2 8378
12
Procaine Approved, Investigational, Vet_approved Phase 3 59-46-1 4914
13
Glycerol Approved, Investigational Phase 3 56-81-5 753
14
Adalimumab Approved Phase 2, Phase 3,Phase 3 331731-18-1 16219006
15
Azathioprine Approved Phase 3 446-86-6 2265
16
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
17
Miconazole Approved, Investigational, Vet_approved Phase 3,Not Applicable 22916-47-8 4189
18
Everolimus Approved Phase 3,Not Applicable 159351-69-6 6442177
19
Sirolimus Approved, Investigational Phase 3,Not Applicable 53123-88-9 46835353 6436030 5284616
20
Mycophenolic acid Approved Phase 3 24280-93-1 446541
21
Tacrolimus Approved, Investigational Phase 3 104987-11-3 445643 439492
22
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 11103-57-4, 68-26-8 445354
23
Cyanocobalamin Approved, Nutraceutical Phase 3,Not Applicable 68-19-9 44176380
24
Cobalamin Experimental Phase 3,Not Applicable 13408-78-1 6438156
25 Hormones Phase 3,Phase 2
26 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1,Early Phase 1
27 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
28 BB 1101 Phase 3,Early Phase 1
29 Anti-Bacterial Agents Phase 3,Phase 2,Not Applicable,Early Phase 1
30 HIV Protease Inhibitors Phase 3
31 Antiemetics Phase 3,Phase 2,Early Phase 1
32 glucocorticoids Phase 3,Phase 2
33 Hormone Antagonists Phase 3,Phase 2
34
protease inhibitors Phase 3
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
36 Peripheral Nervous System Agents Phase 3,Phase 2,Early Phase 1
37 Autonomic Agents Phase 3,Phase 2,Early Phase 1
38 Antineoplastic Agents, Hormonal Phase 3,Phase 2
39 Trace Elements Phase 3,Phase 2,Not Applicable
40 Micronutrients Phase 3,Phase 2,Not Applicable
41 Retinol palmitate Phase 3
42 retinol Phase 3
43 Vitamins Phase 3,Not Applicable
44 Vitamin B12 Phase 3,Not Applicable
45 Vitamin B 12 Phase 3,Not Applicable
46 Central Nervous System Depressants Phase 3,Phase 2,Early Phase 1
47 Anesthetics Phase 3,Phase 2,Early Phase 1
48 Anti-Ulcer Agents Phase 3
49 Anesthetics, Local Phase 3,Phase 2,Early Phase 1
50 Antacids Phase 3

Interventional clinical trials:

(show top 50) (show all 56)
# Name Status NCT ID Phase Drugs
1 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4 infliximab;placebo
2 The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus Unknown status NCT01083420 Phase 3 Minocycline;Dexamethasone
3 Prevention of Recurrent Aphthous Stomatitis Using Vitamins Completed NCT00527306 Phase 3
4 Efficacy of the Combination Bismuth + Neomycin + Procaine in the Treatment of Recurrent Aphthous Ulceration Completed NCT00857688 Phase 3 Bismu-Jet
5 A Study of Adalimumab for the Maintenance of Clinical Remission in Japanese Subjects With Crohn's Disease Completed NCT00445432 Phase 2, Phase 3
6 Efficacy and Safety of Two Treatment Algorithms in Adults With Moderate to Severe Crohn's Disease Completed NCT01235689 Phase 3 Prednisone;Azathioprine
7 Tacrolimus/Everolimus vs. Tacrolimus/MMF in Pediatric Heart Transplant Recipients Using the MATE Score Recruiting NCT03386539 Phase 3 Everolimus;Tacrolimus;Mycophenolate Mofetil
8 Herbal Treatment to Improve Chemotherapy Delivery Not yet recruiting NCT03716518 Phase 3 Tonifying Spleen and Kidney Sequential Regimen;Placebo of 'Tonifying Spleen and Kidney Sequential Regimen
9 Omega-3 and Quality of Life in Recurrent Aphthous Stomatitis Patients Unknown status NCT01831453 Phase 2 omega-3;placebo
10 Evaluation of Therapeutic Effect of 0.5 mg Colchicine and 5 mg Prednisolone on Oral Aphthae Unknown status NCT00723268 Phase 2 Prednisolone;Colchicine
11 Systemic Zinc Sulphate in Treatment of Recurrent Aphthous Ulcerations:A Doubleblind, Placebo Controled Study Completed NCT01210014 Phase 2 zinc sulphate 220mg/day in one dosage;placebo: one dosage
12 Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis Completed NCT01293968 Phase 2 Ibuprofen, Diphenhydramine and Aluminium MgS;Diphenhydramine and Aluminium MgS
13 Efficacy and Safety Study of Yunnan Baiyao on Minor Recurrent Aphthous Stomatitis Completed NCT01652625 Phase 2 Yunnan Baiyao toothpaste;Placebo toothpaste
14 Thalidomide for Treatment of Oral and Esophageal Aphthous Ulcers and HIV Viremia in Patients With HIV Infection Completed NCT00000790 Phase 2 Thalidomide
15 Topical "Non-Aromatic Very Rich in Steranes" (NAVS) Naphthalan for the Treatment of Oral Mucosal Diseases Completed NCT02920658 Phase 2 NAVS Naphthalan;0.05% Betamethasone dipropionate
16 Colchicine Randomized Double-Blind Controlled Crossover Study in Behcet's Disease Completed NCT00700297 Phase 2 Colchicine;Placebo
17 PillCam® Platform With the PillCam Crohn's Disease Capsule Completed NCT01631435 Phase 1, Phase 2
18 Anakinra for Behcet s Disease Completed NCT01441076 Phase 1, Phase 2 Anakinra
19 Thalidomide to Treat Oral Lesions in HIV-Infected Patients Completed NCT00001524 Phase 2 Thalidomide
20 Effectiveness and Safety of Lactobacillus Rhamnosus Lcr35® in the Treatment of Recurrent Aphthous Stomatitis Recruiting NCT02789605 Phase 2 Bacilor;Placebo
21 Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome Recruiting NCT03469232 Phase 1, Phase 2 Huanglian-Jiedu Decoction
22 Vedolizumab Post Op Study Recruiting NCT02834754 Phase 2 Vedolizumab;placebo
23 Efficacy of Adhesive Tablets in Treating Oral Ulcers (Aphthous) Suspended NCT00281723 Phase 2 Pro-Pe adhesive tablet
24 Efficacy, Safety and Tolerability of AIN457 in Moderate to Severe Active Crohn's Disease Terminated NCT00584740 Phase 2 AIN457;Placebo
25 Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of ITF2357 on Mucosal Healing in Patients With Moderate-to-severe Active Crohn's Disease Terminated NCT00792740 Phase 1, Phase 2 ITF2357;Placebo capsules
26 Effectiveness of Topical Thalidomide to Treat Chronic Graft-Versus-Host-Disease Related Stomatitis Terminated NCT00075023 Phase 2 Thalidomide Gel;Placebo Gel
27 Probiotics and Corticosteroids for Treating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) Withdrawn NCT02535962 Phase 2
28 Clinical Evaluation of Fluid Extract of Chamomilla Tincture for Oral Aphthae Completed NCT01122147 Phase 1 chamomilla tincture mouthwash;placebo mouthwash
29 Niosomal Propolis as Oromucoadhesive Film: In-vitro, Ex-vivo & In-vivo Investigations Completed NCT03615820 Phase 1 Niosomal PPE oromucoadhesive film;Oromucoadhesive film
30 Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Recruiting NCT02775994 Phase 1 Canakinumab
31 Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis Completed NCT01501409 Not Applicable
32 Oral Vitamin B12 as Potential Treatment of Recurrent Aphthous Stomatitis Completed NCT00288769 Not Applicable daily sublingual tablets Vitamin B12 1000 mcg versus placebo
33 Treatment of Recurrent Aphthous Stomatitis With Er,Cr:YSGG Laser Irradiation Completed NCT02925182 Not Applicable
34 The Effect of 2-DeNT Oral Topical Powder on Minor Recurrent Aphthous Ulcer Completed NCT02142543 Early Phase 1 2-DeNT powder;Placebo Comparator
35 A Trial of Pentoxifylline for the Treatment of Recurrent Aphthous Stomatitis Completed NCT00315679 Not Applicable Pentoxifylline (also known as oxpentifylline)
36 Abdominal Ultrasound Examination in Non-celiac Wheat Sensitivity Completed NCT03017274
37 Evaluation and Treatment of Oral Soft Tissue Diseases Completed NCT00001601 Not Applicable
38 Special Investigation in Patients With Intestinal Behcet's Disease (All Case Investigation) Completed NCT01960790
39 The Vienna RAP Pilot Study Completed NCT01632605 Not Applicable Sirolimus
40 Tokushima Night Guard for Recurrent Aphthous Stomatitis Recruiting NCT02890524 Early Phase 1
41 The Salivary and Faecal Microbiome of Recurrent Aphthous Stomatitis Patients Before and After Treatment With Probiotics Recruiting NCT02976922 Not Applicable
42 Apremilast for RAS Recruiting NCT03690544 Early Phase 1 Apremilast 30mg
43 Tonsillotomy or Follow-up in PFAPA Syndrome Recruiting NCT03331497 Not Applicable
44 Gynaecological Disorders in Not-celiac Wheat Sensitivity Recruiting NCT03027492 Not Applicable
45 Lactose Intolerance and Cow's Milk Protein Allergy in Non-celiac Wheat Sensitivity Patients Recruiting NCT03008252
46 Fibromyalgia-like Joint/Muscle Pain and Synovitis in Non-celiac Wheat Sensitivity Patients Recruiting NCT03022513 Not Applicable
47 Salivary Cytokines as Biomarker for Oral Health Recruiting NCT02807519
48 Oral Lesions In Non-Celiac Wheat Sensitivity Patients Recruiting NCT02421809
49 Entyvio (Vedolizumab) Long Term Safety Study Recruiting NCT02674308 Vedolizumab
50 Identification of Viruses Associated With Diseases of Unknown Cause Enrolling by invitation NCT00359268

Search NIH Clinical Center for Aphthous Stomatitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: stomatitis, aphthous

Genetic Tests for Aphthous Stomatitis

Genetic tests related to Aphthous Stomatitis:

# Genetic test Affiliating Genes
1 Oral Ulcer 29

Anatomical Context for Aphthous Stomatitis

MalaCards organs/tissues related to Aphthous Stomatitis:

41
Tongue, Bone, Heart, Tonsil, Monocytes, Testes, Neutrophil

Publications for Aphthous Stomatitis

Articles related to Aphthous Stomatitis:

(show top 50) (show all 731)
# Title Authors Year
1
Association of Serotonin Transporter Gene Polymorphism with Recurrent Aphthous Stomatitis. ( 29296268 )
2018
2
Tonsillar antimicrobial peptide (AMP) expression profiles of periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) patients. ( 29859567 )
2018
3
Prevalence and psychological stress in recurrent aphthous stomatitis among female dental students in Saudi Arabia. ( 29785161 )
2018
4
The association between minor recurrent aphthous stomatitis (RAS), children's poor oral condition, and underlying negativeA psychosocial habits and attitudes towards oral hygiene. ( 29653566 )
2018
5
Comorbidity of PFAPA (periodic fever, aphthous stomatitis, pharyngitis and adenitis) patients: a case control study. ( 29533751 )
2018
6
Gastric parietal cell and thyroid autoantibodies in recurrent aphthous stomatitis patients with concomitant oral lichen planus. ( 29753458 )
2018
7
Autosomal dominant deficiency of the interleukin-17F in recurrent aphthous stomatitis: Possible novel mutation in a new entity. ( 29458167 )
2018
8
Associations of IL-1, 6, and 10 Gene Polymorphisms with Susceptibility to Recurrent Aphthous Stomatitis: Insights from a Meta-Analysis. ( 29641282 )
2018
9
Risk factors for periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: a case-control study. ( 29799086 )
2018
10
Association between interleukin family gene polymorphisms and recurrent aphthous stomatitis risk. ( 29550839 )
2018
11
Association of the nod-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population. ( 29430721 )
2018
12
The First International Conference on Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis Syndrome. ( 29246466 )
2018
13
Healthy lifestyle habits benefit remission of recurrent aphthous stomatitis and RAS type ulceration. ( 29327722 )
2018
14
Pregnancy complicated with PFAPA (periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis) syndrome: a case report. ( 29866074 )
2018
15
The role of tonsillectomy in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome; a literature review. ( 29483843 )
2018
16
Hematinic dei-8ciencies in patients with recurrent aphthous stomatitis: variations by gender and age. ( 29476670 )
2018
17
Salivary levels of TNF-I+ in patients with recurrent aphthous stomatitis: A cross-sectional study. ( 29732020 )
2018
18
Relationship between salivary calprotectin levels and recurrent aphthous stomatitis: A preliminary study. ( 29519972 )
2018
19
Examination of serum hematinics and autoantibodies is important for treatment of recurrent aphthous stomatitis. ( 29336939 )
2018
20
Analysis of Dietary Related Factors of Recurrent Aphthous Stomatitis among College Students. ( 29681971 )
2018
21
Haematinic deficiencies and patient clinical profiles in Polish patients with recurrent aphthous stomatitis (RAS). ( 29499093 )
2018
22
The association between interleukin polymorphism and recurrent aphthous stomatitis: A meta-analysis. ( 29800802 )
2018
23
Evidence that Enterobius vermicularis plays a causative role for PFAPA and recurrent aphthous stomatitis. ( 29856193 )
2018
24
Evaluation and Comparison of Total Antioxidant Capacity of Saliva Between Patients with Recurrent Aphthous Stomatitis and Healthy Subjects. ( 29755602 )
2018
25
Association Between Anxiety, Depression, and Salivary Cortisol Levels in Patients with Recurrent Aphthous Stomatitis. ( 30319874 )
2018
26
Celiac disease-specific and inflammatory bowel disease-related antibodies in patients with recurrent aphthous stomatitis. ( 30446336 )
2018
27
Treatment options for periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome in children and adults: a narrative review. ( 30488366 )
2018
28
Establishment of Role of IL-2, IL-10 and IL-12 in Patients with Recurrent Aphthous Stomatitis-A Clinical Study. ( 30498180 )
2018
29
Severe HIV-associated aphthous stomatitis treated with etanercept. ( 30528070 )
2018
30
Chitosan/pvp-based mucoadhesive membranes as a promising delivery system of betamethasone-17-valerate for aphthous stomatitis. ( 29628256 )
2018
31
Correction: Association between interleukin family gene polymorphisms and recurrent aphthous stomatitis risk. ( 29985443 )
2018
32
Interleukin-4 and Interleukin-4 Receptor Alpha Gene Polymorphisms in Recurrent Aphthous Stomatitis. ( 29985726 )
2018
33
Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case-control frequency-matched study. ( 30009475 )
2018
34
Familial Mediterranean fever and periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: shared features and main differences. ( 30019226 )
2018
35
Effect of 0.5% Chitosan mouthwash on recurrent aphthous stomatitis: a randomized double-blind crossover clinical trial. ( 30034658 )
2018
36
Comment on "Mean Platelet Volume: A Reliable Marker of Inflammation in Recurrent Aphthous Stomatitis and Behçet's Disease?" ( 30050826 )
2018
37
Aphthous Stomatitis Major in a 4-Month-Old Infant. ( 30297194 )
2018
38
Aphthous Stomatitis and Laryngitis, Another Form of Presentation of an IgG4-Related Disease? ( 30297197 )
2018
39
Patients who seek professional treatment of recurrent aphthous stomatitis probably have an increased risk of having head and neck cancer and other types of cancers. ( 30340756 )
2018
40
Recurrent aphthous stomatitis and gene variability in selected interleukins: a case-control study. ( 30341786 )
2018
41
Comorbidity profiles among patients with recurrent aphthous stomatitis: A case-control study. ( 30348492 )
2018
42
Familial Mediterranean Fever Is Commonly Diagnosed in Children in Israel with Periodic Fever Aphthous Stomatitis, Pharyngitis, and Adenitis Syndrome. ( 30361059 )
2018
43
Vitamin D levels in patients with recurrent aphthous stomatitis. ( 30413195 )
2018
44
Recurrent aphthous stomatitis - Etiology, serum autoantibodies, anemia, hematinic deficiencies, and management. ( 30446298 )
2018
45
Therapeutic effect of Aloe vera and silver nanoparticles on acid-induced oral ulcer in gamma-irradiated mice. ( 29412224 )
2018
46
Gastrointestinal: Improvement of refractory oral ulcer of Behçet's disease after eradication of Helicobacter pylori. ( 29469234 )
2018
47
Endothelin-1 Elicits TRP-Mediated Pain in an Acid-Induced Oral Ulcer Model. ( 29518348 )
2018
48
Curative effect of oral ulcer powder on the treatment of recurrent aphthous ulcer. ( 29735470 )
2018
49
Polysaccharides from tubers of Bletilla striata: Physicochemical characterization, formulation of buccoadhesive wafers and preliminary study on treating oral ulcer. ( 30227203 )
2018
50
Oral ulcer due to dabigatran capsule. ( 30287622 )
2018

Variations for Aphthous Stomatitis

Expression for Aphthous Stomatitis

Search GEO for disease gene expression data for Aphthous Stomatitis.

Pathways for Aphthous Stomatitis

Pathways related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 HLA-A HLA-B IL10 IL1B IL1RN IL2
2
Show member pathways
13.63 IL10 IL1B IL1RN IL2 IL4 IL6
3
Show member pathways
13.41 IL10 IL1B IL2 IL4 IL6 TLR2
4
Show member pathways
13.34 HLA-A HLA-B IL10 IL1B IL1RN IL2
5
Show member pathways
13.27 IL10 IL1B IL2 IL4 IL6 TNF
6
Show member pathways
13.07 HLA-A HLA-B IL1B IL6 TLR2 TNF
7
Show member pathways
13.04 HLA-A HLA-B IL2 IL4 IL6 TLR2
8
Show member pathways
13.01 IL10 IL1B IL2 IL6 MEFV NLRP3
9
Show member pathways
12.82 HLA-A HLA-B IL10 IL1B IL2 IL4
10
Show member pathways
12.73 IL1B IL2 IL6 TLR2 TNF
11
Show member pathways
12.63 IL10 IL1B IL2 IL6 TNF
12
Show member pathways
12.6 IL10 IL2 IL4 TNF
13
Show member pathways
12.6 HLA-A HLA-B IL1B IL2 IL4 IL6
14
Show member pathways
12.57 HLA-A HLA-B IL2 IL4 TNF
15
Show member pathways
12.54 IL10 IL1B IL2 IL4 IL6 TLR2
16 12.49 HLA-A HLA-B IL2 IL6 TNF
17 12.49 IL10 IL1B IL1RN IL2 IL4 TLR2
18
Show member pathways
12.47 IL10 IL1B IL2 IL4 IL6 TNF
19
Show member pathways
12.41 IL1B IL2 IL4 IL6 TNF
20
Show member pathways
12.41 IL1B IL4 IL6 TLR2 TNF
21
Show member pathways
12.4 IL10 IL2 IL4 IL6
22 12.37 HLA-A HLA-B IL6 TLR2 TNF
23
Show member pathways
12.33 IL10 IL1B IL4 TLR2 TNF
24 12.31 IL10 IL1B IL6 TLR2 TNF
25
Show member pathways
12.3 IL1B IL1RN IL6 TLR2 TNF
26
Show member pathways
12.26 IL1B IL4 IL6 TLR2 TNF
27 12.25 IL10 IL1B IL1RN IL6 TNF
28
Show member pathways
12.21 IL10 IL1B IL2 IL6 NLRP3 TNF
29
Show member pathways
12.13 IL1B IL4 IL6 TLR2 TNF
30
Show member pathways
12.13 HLA-A HLA-B IL10 IL1B IL2 IL4
31
Show member pathways
12.12 IL10 IL1B IL2 IL4 IL6
32 12.11 HLA-A HLA-B TLR2
33 12.1 IL1B IL2 IL4 IL6 TNF
34 12.07 IL10 IL2 IL4 IL6 TNF
35 12.06 IL10 IL1B IL4 IL6 TNF
36
Show member pathways
12.05 HLA-A IL1B IL2 IL4
37
Show member pathways
12.01 IL1B IL2 TLR2
38 11.98 IL1B IL4 IL6 TNF
39
Show member pathways
11.96 IL10 IL1B IL2 IL6 TLR2 TNF
40 11.95 IL1B IL6 TNF
41 11.95 IL10 IL1B IL6 TLR2 TNF
42 11.94 IL1B IL6 TLR2 TNF
43 11.91 IL1B IL6 TNF
44 11.86 IL10 IL2 IL6
45 11.85 IL10 IL1B IL2 IL4 TNF
46 11.82 IL2 IL4 IL6
47 11.82 IL10 IL1B IL6 NLRP3 TNF
48
Show member pathways
11.79 IL2 IL4 TNF
49 11.79 IL10 IL1B IL2 IL6 TNF
50 11.77 IL1B IL4 IL6 TNF

GO Terms for Aphthous Stomatitis

Cellular components related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 IL10 IL1B IL1RN IL2 IL4 IL6
2 MHC class I protein complex GO:0042612 9.26 HLA-A HLA-B
3 extracellular region GO:0005576 9.23 IL10 IL1B IL1RN IL2 IL4 IL6
4 phagocytic vesicle membrane GO:0030670 9.13 HLA-A HLA-B TLR2

Biological processes related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.95 IL10 IL1B IL1RN IL2 IL4 IL6
2 positive regulation of JNK cascade GO:0046330 9.89 IL1B IL1RN TNF
3 positive regulation of inflammatory response GO:0050729 9.88 IL2 TLR2 TNF
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.88 IL10 IL1B IL6 TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 IL1B IL6 NLRP3 TLR2 TNF
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.87 IL2 IL4 IL6
7 negative regulation of inflammatory response GO:0050728 9.87 IL10 IL2 MEFV NLRP3
8 defense response to Gram-positive bacterium GO:0050830 9.86 IL6 NLRP3 TLR2 TNF
9 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.83 IL1B TLR2 TNF
10 positive regulation of interferon-gamma production GO:0032729 9.81 IL1B IL2 TNF
11 positive regulation of T cell proliferation GO:0042102 9.81 IL1B IL2 IL4 IL6
12 positive regulation of JUN kinase activity GO:0043507 9.8 IL1B IL1RN TNF
13 cellular response to lipopolysaccharide GO:0071222 9.8 IL10 IL1B IL1RN IL6 NLRP3 TNF
14 lipopolysaccharide-mediated signaling pathway GO:0031663 9.78 IL1B TLR2 TNF
15 positive regulation of interleukin-8 production GO:0032757 9.77 IL1B TLR2 TNF
16 negative regulation of neurogenesis GO:0050768 9.77 IL1B IL6 TNF
17 response to glucocorticoid GO:0051384 9.77 IL10 IL1B IL1RN IL6 TNF
18 positive regulation of T cell differentiation GO:0045582 9.73 IL2 IL4
19 microglial cell activation GO:0001774 9.73 TLR2 TNF
20 negative regulation of lipid catabolic process GO:0050995 9.73 IL1B TNF
21 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.73 IL1B TNF
22 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IL1B TNF
23 negative regulation of growth of symbiont in host GO:0044130 9.72 IL10 TNF
24 negative regulation of interleukin-12 production GO:0032695 9.72 IL10 MEFV
25 positive regulation of immunoglobulin secretion GO:0051024 9.72 IL2 IL6
26 response to molecule of bacterial origin GO:0002237 9.72 IL10 TLR2
27 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.72 IL10 IL1RN
28 positive regulation of chemokine production GO:0032722 9.72 IL6 TLR2 TNF
29 positive regulation of isotype switching to IgG isotypes GO:0048304 9.71 IL2 IL4
30 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.71 HLA-A HLA-B
31 negative regulation of lipid storage GO:0010888 9.71 IL6 TNF
32 positive regulation of interleukin-13 production GO:0032736 9.71 IL4 NLRP3
33 positive regulation of glial cell proliferation GO:0060252 9.71 IL1B IL6 TNF
34 endothelial cell apoptotic process GO:0072577 9.7 IL10 TNF
35 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IL1B TNF
36 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 IL10 IL1B TNF
37 cytokine-mediated signaling pathway GO:0019221 9.7 IL10 IL1B IL1RN IL2 IL4 IL6
38 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.69 HLA-A HLA-B
39 negative regulation of glutamate secretion GO:0014050 9.68 IL1B IL1RN
40 positive regulation of MHC class II biosynthetic process GO:0045348 9.68 IL10 IL4
41 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
42 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 IL10 TNF
43 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.67 IL6 NLRP3
44 interleukin-1 beta production GO:0032611 9.67 IL1B NLRP3
45 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.67 IL1RN IL6
46 positive regulation of fever generation GO:0031622 9.66 IL1B TNF
47 protection from natural killer cell mediated cytotoxicity GO:0042270 9.66 HLA-A HLA-B
48 regulation of isotype switching GO:0045191 9.65 IL10 IL4
49 sequestering of triglyceride GO:0030730 9.65 IL1B TNF
50 positive regulation of interleukin-6 production GO:0032755 9.65 IL1B IL1RN IL6 TLR2 TNF

Molecular functions related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidoglycan binding GO:0042834 9.26 NLRP3 TLR2
2 growth factor activity GO:0008083 9.26 IL10 IL2 IL4 IL6
3 cytokine activity GO:0005125 9.17 IL10 IL1B IL1RN IL2 IL4 IL6
4 interleukin-1 receptor binding GO:0005149 9.16 IL1B IL1RN

Sources for Aphthous Stomatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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