MCID: APH001
MIFTS: 57

Aphthous Stomatitis

Categories: Oral diseases, Rare diseases

Aliases & Classifications for Aphthous Stomatitis

MalaCards integrated aliases for Aphthous Stomatitis:

Name: Aphthous Stomatitis 12 74 52 15 71
Oral Ulcer 12 54 71
Minor Oral Aphthous Ulceration 71
Stomatitis, Aphthous 43
Aphthous Ulceration 12
Oral Aphthous Ulcer 12
Oral Aphthae 12
Canker Sores 42
Canker Sore 12
Aphtha 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9663
ICD9CM 34 528.2
MeSH 43 D013281
NCIt 49 C62546
SNOMED-CT 67 426965005
UMLS 71 C0038363 C0149745 C0585213

Summaries for Aphthous Stomatitis

MedlinePlus : 42 Canker sores are small, round sores in your mouth. They can be on the inside of your cheek, under your tongue, or in the back of your throat. They usually have a red edge and a gray center. They can be quite painful. They are not the same as cold sores, which are caused by herpes simplex. Canker sores aren't contagious. They may happen if you have a viral infection. They may also be triggered by stress, food allergies, lack of vitamins and minerals, hormonal changes or menstrual periods. In some cases the cause is unknown. In most cases, the sores go away by themselves. Some ointments, creams or rinses may help with the pain. Avoiding hot, spicy food while you have a canker sore also helps.

MalaCards based summary : Aphthous Stomatitis, also known as oral ulcer, is related to mouth disease and orofacial granulomatosis, and has symptoms including oral mucosal blisters, enanthema and snoring. An important gene associated with Aphthous Stomatitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Chlorhexidine and Vitamin C have been mentioned in the context of this disorder. Affiliated tissues include tongue, bone and neutrophil, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased viability with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A stomatitis characterized by the repeated formation of benign and non-contagious mouth ulcers.

Wikipedia : 74 Aphthous stomatitis is a common condition characterized by the repeated formation of benign and... more...

Related Diseases for Aphthous Stomatitis

Diseases related to Aphthous Stomatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 926)
# Related Disease Score Top Affiliating Genes
1 mouth disease 32.5 TLR4 IL6 IL10 IFNG
2 orofacial granulomatosis 32.4 TNF IL4 IL10 IFNG
3 mevalonic aciduria 32.1 TNF NLRP3 MEFV IL1RN IL1B IL18
4 cervical adenitis 32.0 NLRP3 MEFV IL1RN IL1B
5 glossitis 31.2 TNF IL6 IL1B
6 pharyngitis 31.2 TNF NLRP3 MEFV IL6 IL1RN IL1B
7 pemphigus 31.1 TNF IL6 IL4 IL10
8 ige responsiveness, atopic 31.1 IL4 IL10 IFNG
9 hereditary periodic fever syndrome 30.8 TNF NLRP3 MEFV
10 oral candidiasis 30.8 IL1RN IL1A CXCL8
11 folliculitis 30.7 TNF IL4 IFNG
12 peptic ulcer disease 30.7 TNF IL1RN IL1B IL10 CXCL8
13 proliferative glomerulonephritis 30.7 IL6 IL4 IFNG
14 herpes simplex 30.7 TNF TLR2 IL6 HLA-B
15 laryngitis 30.7 TNF IL6 IL1B IL1A
16 cyclic neutropenia 30.7 TNF IL1B IFNG CXCL8 CSF2
17 vasculitis 30.7 TNF MEFV IL6 IL10 HLA-B
18 intestinal perforation 30.7 TNF TLR4 IL6
19 anxiety 30.7 TNF IL6 IL1B ACE
20 burning mouth syndrome 30.6 TNF IL6 IL2 IL1B CXCL8
21 meningoencephalitis 30.6 TNF IL6 IL4 IL1B IL10
22 stomatitis 30.6 TNF TLR4 NLRP3 MEFV IL6 IL4
23 mucositis 30.5 IL2 IL1B IL10 CSF2
24 acute disseminated encephalomyelitis 30.5 IL1B IL10 HLA-B
25 spondyloarthropathy 1 30.5 TNF TLR4 IL1RN HLA-B
26 lichen planus 30.5 TNF TLR2 IL6 IL4 IL2 IL10
27 urticaria 30.5 TNF NLRP3 IL6 IL4 IL10
28 pustulosis of palm and sole 30.5 TNF IL1RN CXCL8
29 encephalitis 30.5 TNF TLR2 IL6 IL4 IL1B IL10
30 viral encephalitis 30.5 TNF IL6 IL1B IL10 CXCL8
31 mental depression 30.5 TNF IL6 IL1B
32 histoplasmosis 30.5 TNF IFNG HLA-B HLA-A
33 chickenpox 30.5 TNF TLR2 IL6 IL4 IL2 IL10
34 atrophic gastritis 30.5 TNF IL6 IL1RN IL1B IL10 CXCL8
35 hypopyon 30.5 TNF IL6 IL10 HLA-B
36 liver disease 30.4 TNF IL6 IL1B IL1A CXCL8
37 gastritis 30.4 TNF TLR4 IL6 IL1RN IL1B IL10
38 genital herpes 30.4 TLR2 IL4 IL18 IL10
39 chikungunya 30.4 TNF IL6 IL1B IL18
40 gastric ulcer 30.4 TNF IL6 IL1RN IL1B CXCL8
41 chronic graft versus host disease 30.4 IL1A IL10 IFNG
42 spondylitis 30.4 TNF IL6 IL1RN IL10 IFNG HLA-B
43 osteonecrosis 30.4 TNF IL1B IL10
44 wells syndrome 30.3 NLRP3 MEFV IL2 IL1B CXCL8
45 crohn's colitis 30.3 TNF IL2 IL1B IFNG CXCL8
46 glucose metabolism disease 30.3 TNF IL6 IL1B IL10 ACE
47 lymphopenia 30.3 IL6 IL4 IL2 IL18 IL10 IFNG
48 hidradenitis suppurativa 30.3 TNF TLR4 IL1B IFNG
49 hidradenitis 30.3 TNF TLR4 IL1B IFNG
50 esophagitis 30.3 TNF IL6 IL4 IL1B IL10 CXCL8

Graphical network of the top 20 diseases related to Aphthous Stomatitis:



Diseases related to Aphthous Stomatitis

Symptoms & Phenotypes for Aphthous Stomatitis

UMLS symptoms related to Aphthous Stomatitis:


oral mucosal blisters, enanthema, snoring, halitosis, oral manifestations, sore mouth

GenomeRNAi Phenotypes related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-1 9.73 ACE IL2
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-2 9.73 ACE IL10 IL18 IL1A IL1B IL2
3 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.73 CD40 IL1A
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.5 CXCL8 IL10 IL18 IL1A IL1B NLRP3
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.5 ACE CXCL8 IL10 IL18 IL1B IL2

MGI Mouse Phenotypes related to Aphthous Stomatitis:

45 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.46 ACE CD40 CSF2 HLA-A IFNG IL10
2 immune system MP:0005387 10.43 ACE CD40 CSF2 HLA-A IFNG IL10
3 homeostasis/metabolism MP:0005376 10.42 ACE CD40 CSF2 IFNG IL10 IL18
4 growth/size/body region MP:0005378 10.4 ACE CSF2 IFNG IL10 IL18 IL1B
5 cardiovascular system MP:0005385 10.38 ACE CSF2 IFNG IL10 IL18 IL1A
6 cellular MP:0005384 10.37 CSF2 IFNG IL10 IL18 IL1RN IL2
7 mortality/aging MP:0010768 10.31 ACE CSF2 HLA-A IFNG IL10 IL18
8 integument MP:0010771 10.3 CSF2 IFNG IL10 IL18 IL1A IL1B
9 endocrine/exocrine gland MP:0005379 10.28 ACE CD40 CSF2 HLA-A IFNG IL10
10 digestive/alimentary MP:0005381 10.25 IFNG IL10 IL18 IL2 IL4 IL6
11 adipose tissue MP:0005375 10.18 ACE CSF2 IL18 IL6 NLRP3 TLR2
12 liver/biliary system MP:0005370 10.17 ACE IFNG IL10 IL2 IL4 IL6
13 nervous system MP:0003631 10.13 CD40 CSF2 HLA-A IFNG IL10 IL18
14 neoplasm MP:0002006 10.11 ACE CSF2 IFNG IL10 IL1A IL1B
15 reproductive system MP:0005389 9.93 ACE CSF2 IFNG IL10 IL1RN IL2
16 renal/urinary system MP:0005367 9.91 ACE CD40 CSF2 IFNG IL4 IL6
17 respiratory system MP:0005388 9.61 CSF2 IFNG IL10 IL2 IL4 IL6
18 skeleton MP:0005390 9.44 CD40 CSF2 IFNG IL10 IL1B IL1RN

Drugs & Therapeutics for Aphthous Stomatitis

Drugs for Aphthous Stomatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 145)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
2
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
3 Vitamins Phase 4
4 Chlorhexidine gluconate Phase 4
5 Anti-Infective Agents Phase 4
6 Aloe Phase 4
7 Anti-Infective Agents, Local Phase 4
8
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
9
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
10
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
11
Flavin Mononucleotide Approved, Investigational Phase 3 146-17-8 643976
12
Glycerol Approved, Investigational Phase 3 56-81-5 753
13
Hyaluronic acid Approved, Vet_approved Phase 3 9004-61-9 53477741
14
Adalimumab Approved Phase 2, Phase 3 331731-18-1 16219006
15
Apremilast Approved, Investigational Phase 3 608141-41-9 11561674
16
Clotrimazole Approved, Vet_approved Phase 2, Phase 3 23593-75-1 2812
17
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
18
Sirolimus Approved, Investigational Phase 2, Phase 3 53123-88-9 5284616 6436030 46835353
19
tannic acid Approved Phase 2, Phase 3 1401-55-4
20
Benzocaine Approved, Investigational Phase 2, Phase 3 94-09-7, 1994-09-7 2337
21
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
22
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 3 83-88-5 493570
23
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
24 Micronutrients Phase 3
25 Trace Elements Phase 3
26 Nutrients Phase 3
27 Folate Phase 3
28 Vitamin B9 Phase 3
29 Antineoplastic Agents, Hormonal Phase 3
30 Gastrointestinal Agents Phase 3
31 Antiemetics Phase 3
32 Mesalamine Phase 3 89-57-6
33 Photosensitizing Agents Phase 3
34 Vitamin B2 Phase 3
35 Retinol palmitate Phase 3
36 retinol Phase 3
37 Viscosupplements Phase 3
38 Adjuvants, Immunologic Phase 3
39 Angiogenesis Inhibitors Phase 3
40 Antirheumatic Agents Phase 3
41 Anti-Inflammatory Agents Phase 3
42 Analgesics Phase 3
43 Analgesics, Non-Narcotic Phase 3
44 Anti-Inflammatory Agents, Non-Steroidal Phase 3
45 Immunologic Factors Phase 2, Phase 3
46 Immunosuppressive Agents Phase 2, Phase 3
47 Anti-Bacterial Agents Phase 2, Phase 3
48 Antihypertensive Agents Phase 2, Phase 3
49 Antifungal Agents Phase 2, Phase 3
50 Antibiotics, Antitubercular Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 72)
# Name Status NCT ID Phase Drugs
1 Aloe Vera and Chlorhexidine as Preventive Oral Antiseptics Against the Appearance of Traumatic Oral Ulcers in Patients With Fixed Orthodontics: a Randomized Clinical Trial Completed NCT03633292 Phase 4 Antiseptic clorhexidine gel (Lacer, Barcelona, Spain);Master formula of aloe vera gel 80%
2 The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus. A Randomized Controlled Trial Unknown status NCT01083420 Phase 3 Minocycline;Dexamethasone
3 The Efficacy of Topically Applied Mesalazine Sustained-Release Tablets in Oral Lesions of Crohn's Disease Unknown status NCT02769494 Phase 3 Mesalazine Sustained-Release Tablets;Riboflavin Sodium Phosphate Injection
4 Randomized Controlled Trials of Diet and Lifestyle Intervention to Promote Chinese Postpartum Women's Health Unknown status NCT01039051 Phase 2, Phase 3
5 Prevention of Recurrent Aphthous Stomatitis Using Vitamins Completed NCT00527306 Phase 3
6 Effectiveness of Topical Hyaluronic Acid Versus Chlorhexidine Mouthwashes in the Treatment of Recurrent Aphthous Stomatitis: A Randomized Clinical Trial Completed NCT04265001 Phase 3 Hyaluronic acid in the form of hyaluronan sodium 25 mg/100 ml as a mouthwash
7 A Multi-Center, Randomized, Double-blind, Placebo-controlled Study of Adalimumab for the Maintenance of Clinical Remission in Japanese Subjects With Crohn's Disease Completed NCT00445432 Phase 2, Phase 3
8 Randomized Controlled Double-blind Vs. Placebo Multicentre Study on the Safety and Effectiveness of Thalidomide in the Treatment of Refractory Crohn's Disease and Ulcerative Colitis. Completed NCT00720538 Phase 3 Thalidomide;placebo
9 Randomized Double Blind Controlled Trial Comparing the Safety and Efficacy of Apremilast Versus Placebo in Severe Forms of Recurrent Aphthous Stomatitis Not yet recruiting NCT04227314 Phase 3 Apremilast;Placebo oral tablet
10 EFFECTS OF SIROLIMUS ON DISEASE PROGRESSION IN PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE AND SEVERE RENAL INSUFFICIENCY Terminated NCT01223755 Phase 2, Phase 3 Sirolimus;conventional therapy
11 Evaluation of Therapeutic Effect of 0.5 mg Colchicine and 5 mg Prednisolone on Oral Aphthae Unknown status NCT00723268 Phase 2 Prednisolone;Colchicine
12 Therapeutic Effect of Systemic Omega-3 Polyunsaturated Fatty Acids On Quality of Life in Patients Suffering From Recurrent Aphthous Stomatitis Unresponsive to Topical Therapy. Unknown status NCT01831453 Phase 2 omega-3;placebo
13 Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome (Acute Pericoronitis, Minor Recurrent Aphthous Stomatitis and Recurrent Herpes Simplex Labialis) Unknown status NCT03469232 Phase 1, Phase 2 Huanglian-Jiedu Decoction
14 Efficacy and Safety of FORRAD® for the Management of Radiation-induced Mucositis in Patients With Nasopharyngeal Carcinoma Receiving IMRT: A Single-center, Randomized Controlled Trial Unknown status NCT02735317 Phase 2 Oral Ulcer Gargle (FORRAD®);Quadruple mixture, composed of dexamethasone, gentamicin, vitamin B12, and procaine
15 Sucralfate to Improve Oral Intake in Children With Infectious Oral Ulcers: a Randomized, Double-blind, Placebo-Controlled Trial Unknown status NCT03241030 Phase 2 Sucralfate;Acetaminophen;Ibuprofen
16 Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis Completed NCT01293968 Phase 2 Ibuprofen, Diphenhydramine and Aluminium MgS;Diphenhydramine and Aluminium MgS
17 Efficacy and Safety Study of Yunnan Baiyao on Minor Recurrent Aphthous Stomatitis Completed NCT01652625 Phase 2 Yunnan Baiyao toothpaste;Placebo toothpaste
18 Thalidomide for Treatment of Oral and Esophageal Aphthous Ulcers and HIV Viremia in Patients With HIV Infection Completed NCT00000790 Phase 2 Thalidomide
19 Zinc Sulphate in Treatment of Recurrent Aphthous Stomatitis Completed NCT01210014 Phase 2 zinc sulphate 220mg/day in one dosage;placebo: one dosage
20 Nonaromatic Naphthalan - Composition Study and Biological Effects on Epithelial Tissues Completed NCT02920658 Phase 2 NAVS Naphthalan;0.05% Betamethasone dipropionate
21 Phase II, Multicenter, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Ranging Study of the Effects of RK-0202 on Oral Mucositis in Patients Receiving Radiation Therapy for Tumors of the Oral Cavity, Oropharynx, Nasopharynx, Salivary Glands or Supraglottic Region Completed NCT00230191 Phase 2 RK-0202
22 Clinical Protocol for Administration of Topical Pentoxifylline Gel on Behcet's Disease Oral Ulcers Recruiting NCT03888846 Phase 2 Pentoxifylline;Colchicine
23 Use of Ustekinumab (Anti-IL-12/23p40 Monoclonal Antibody) in Patients With Leukocyte Adhesion Deficiency Type 1 (LAD1) Who Have Inflammatory Pathology Recruiting NCT03366142 Phase 1, Phase 2 Ustekinumab
24 Treatment of Idiopathic and Recurrent Aphthous Stomatitis by a Probiotic, the Lactobacillus Rhamnosus Lcr35® : a Randomized, Double Blind and Placebo-controlled Trial Active, not recruiting NCT02789605 Phase 2 Bacilor;Placebo
25 Clinical Protocol to Evaluate Use of Topical Pentoxifylline Gel on Behcet's Disease Genital Ulcers Not yet recruiting NCT04186559 Phase 2 Topical Pentoxifylline Gel (Vehicle +PTX);Topical Placebo Gel (Vehicle)
26 Phase 2 Study of Efficacy of Adhesive Tablets in Treating Oral Ulcers (Aphthous) Suspended NCT00281723 Phase 2 Pro-Pe adhesive tablet
27 Evaluation of Efficacy and Mechanisms of Topical Thalidomide for Chronic Graft-Versus-Host-Disease Related Stomatitis Terminated NCT00075023 Phase 2 Thalidomide Gel;Placebo Gel
28 Effects of Probiotic Addition to Corticosteroid Treatment for PFAPA Withdrawn NCT02535962 Phase 2
29 Phase 1 Evaluation of Therapeutic Effect of Chamomilla Tincture Mouthwash on Oral Aphthae Completed NCT01122147 Phase 1 chamomilla tincture mouthwash;placebo mouthwash
30 Phase 1 1 Study Assesing the Benefit of Pasteurized Goat Milk in Reducing Disease Severity of Young Children With Oral Ulcer Diseases Completed NCT00333749 Phase 1
31 Propolis-based Nanovesicles as Oromuco-adhesive Film: Novel Therapeutic Drug Delivery System for Treatment of Oral Recurrent Aphthous Ulcer Completed NCT03615820 Phase 1 Niosomal PPE oromucoadhesive film;Oromucoadhesive film
32 Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Recruiting NCT02775994 Phase 1 Canakinumab
33 Platelet Rich-plasma in Management of Chronic Multiple Oral Ulcers Not yet recruiting NCT03878771 Phase 1 Dermovate cream in Orabase
34 Clinical Evaluation of Topical Coenzyme Q10 in Management of Oral Aphthous Ulcer Unknown status NCT03213769 topical coenzyme Q10 gel;Carpabol gel
35 Characterisation of the Salivary and Faecal Microbiome in Patients With Recurrent Aphthous Stomatitis Before and After Treatment With Probiotics Unknown status NCT02976922
36 Oral Vitamin B12 as Potential Treatment of Recurrent Aphthous Stomatitis Completed NCT00288769 daily sublingual tablets Vitamin B12 1000 mcg versus placebo
37 Effects of a Night Guard on Aphthous Stomatitis Completed NCT02890524
38 Treatment of Recurrent Aphthous Stomatitis With Er,Cr:YSGG Laser Irradiation: A Randomized Controlled Clinical Study Completed NCT02925182
39 The Effect of 2-DeNT Oral Topical Powder on Minor Recurrent Aphthous Ulcer Completed NCT02142543 Early Phase 1 2-DeNT powder;Placebo Comparator
40 Evaluation of the Effect of Probiotic Lozenges in the Treatment of Recurrent Aphthous Stomatitis: a Randomized, Controlled Clinical Trial Completed NCT04383236 Oracure oral gel
41 A Trial of Pentoxifylline for the Treatment of Recurrent Aphthous Stomatitis Completed NCT00315679 Pentoxifylline (also known as oxpentifylline)
42 Comparison of Curcumin and NanoCurcumin in Recurrent Aphthous Stomatitis Completed NCT04385979
43 Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis : a Randomised Clinical Trial Completed NCT01501409
44 Patient Evaluation and Treatment of Oral Soft Tissue Diseases According to Generally Available, Standard Procedures and Therapeutic Modalities Completed NCT00001601
45 Gynaecological Disorders in Patients With Not-celiac Wheat Sensitivity Completed NCT03027492
46 Fibromyalgia-like Joint/Muscle Pain and Synovitis in Non-celiac Wheat Sensitivity Patients Completed NCT03022513
47 Abdominal Ultrasound Examination in Patients Affected With Non-celiac Wheat Sensitivity Completed NCT03017274
48 Evaluation of Capsule Endoscopy in Patients With Suspected Crohn's Disease Completed NCT00487396
49 Workflow Validation of an In-Home Feedback Controlled Mandibular Positioner Completed NCT03616327
50 Duodenal and Rectal Histology in Non-celiac Wheat Sensitivity and Irritable Bowel Syndrome Patients Completed NCT03022994

Search NIH Clinical Center for Aphthous Stomatitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Benzocaine
BENZOCAINE PWDR
Levonordefrin
Thalidomide

Cochrane evidence based reviews: stomatitis, aphthous

Genetic Tests for Aphthous Stomatitis

Anatomical Context for Aphthous Stomatitis

MalaCards organs/tissues related to Aphthous Stomatitis:

40
Tongue, Bone, Neutrophil, Skin, Kidney, Bone Marrow, Thyroid

Publications for Aphthous Stomatitis

Articles related to Aphthous Stomatitis:

(show top 50) (show all 1885)
# Title Authors PMID Year
1
Oral lesions as first clinical manifestations of Crohn's disease in paediatric patients: a report on 8 cases. 42 61
32183532 2020
2
Substantiation of diagnosis and treatment of chronic recurrent aphthous stomatitis in crohn's disease. 61 42
32285824 2020
3
Mosaic Small Supernumerary Marker Chromosome Derived from Five Discontinuous Regions of Chromosome 8 in a Patient with Neutropenia and Oral Aphthous Ulcer. 42
31982875 2020
4
Association of salivary S. mutans colonisation and mannose-binding lectin deficiency with gender in Behçet's disease. 61 54
19796530 2009
5
Depression symptoms and recurrent aphthous stomatitis-Evidence from a population-based study in Indonesia. 61
32031742 2020
6
Vitamin D and hematinic deficiencies in patients with recurrent aphthous stomatitis. 61
31680206 2020
7
Common genetic susceptibility loci link PFAPA syndrome, Behçet's disease, and recurrent aphthous stomatitis. 61
32518111 2020
8
Effect of heat-clearing and detoxifying Chinese medicines combined with conventional therapy on mild hand, foot, and mouth disease with fever: An individual patient data meta-analysis. 61
32501994 2020
9
Disseminated Histoplasmosis and Miliary Tuberculosis Imitating Colon Cancer in Patient with HIV Who Refuses to Antirretroviral Treatment. 61
32385592 2020
10
Celiac disease and hematological abnormalities in children with recurrent aphthous stomatitis. 61
31957941 2020
11
Why and How Should We Treat Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome? 61
32342289 2020
12
A family-based genome-wide association study of recurrent aphthous stomatitis. 61
32558109 2020
13
Behcet's-like syndrome following pembrolizumab: An immune-related adverse event associated with programmed death receptor-1 inhibitor therapy. 61
31575354 2020
14
A study on the protective effect of molecular hydrogen on osteoradionecrosis of the jaw in rats. 61
32451233 2020
15
The association between serum zinc levels and subjective symptoms in zinc deficiency patients with chronic liver disease. 61
32523253 2020
16
Oral bacterial diversity is inversely correlated with mucosal inflammation. 61
32419230 2020
17
Recurrent Aphthous Stomatitis. 61
32451064 2020
18
The Macrophage Responses during Diabetic Oral Ulcer Healing by Liquid Coconut Shell Smoke: An Immunohistochemical Analysis. 61
32447753 2020
19
Risk factors associated with extraintestinal manifestations in children with inflammatory bowel disease. 61
31395971 2020
20
Probiotics for recurrent idiopathic aphthous stomatitis in adults: a placebo-controlled randomized trial. 61
31954066 2020
21
Photobiomodulation therapy for the management of recurrent aphthous stomatitis in children: clinical effectiveness and parental satisfaction. 61
32388522 2020
22
The effects of licorice containing diphenhydramine solution on recurrent aphthous stomatitis: A double-blind, randomized clinical trial. 61
32444056 2020
23
Experience of Chikungunya in a Chikungunya Clinic at Tertiary Medical College Hospital in Bangladesh. 61
32506101 2020
24
Consensus treatment plans for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA): a framework to evaluate treatment responses from the childhood arthritis and rheumatology research alliance (CARRA) PFAPA work group. 61
32293478 2020
25
Cryptococcal pneumonia in an adolescent with a gain-of-function variant in signal transduction and activator of transcription 1 (STAT1). 61
32327459 2020
26
Clinical efficacy and safety of apatinib combined with S-1 in advanced esophageal squamous cell carcinoma. 61
31650447 2020
27
Autoinflammatory Diseases in Childhood 61
32338845 2020
28
Surgical outcomes and unique histological features of tonsils after tonsillectomy in adults with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. 61
31495531 2020
29
Long-term management of patients with PFAPA syndrome. 61
32239314 2020
30
Complicated intraoral defects: reconstruction using a three-paddle perforator free flap. A case report. 61
31862118 2020
31
Value of colchicine as treatment for recurrent oral ulcers: A systematic review. 61
32281694 2020
32
Analysis of Interleukin-1 Receptor Antagonist Variable Number Tandem Repeat Variant in Recurrent Aphthous Stomatitis 61
32282310 2020
33
Comparison of microbiomes in ulcerative and normal mucosa of recurrent aphthous stomatitis (RAS)-affected patients. 61
32349736 2020
34
Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome: A debate about diagnosis and treatment in children continues. 61
31866107 2020
35
The immunology of the periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome; what can the tonsils reveal. A literature review. 61
31786522 2020
36
Positioning of apremilast in treatment of Behçet's disease. 61
31747804 2020
37
Takayasu's arteritis: associated inflammatory diseases. 61
31969224 2020
38
Diagnostic Rate of Autoinflammatory Diseases Evaluated by Fever Patterns in Pediatric- and Adult-Onset Patients. 61
32073516 2020
39
Comprehensive expression profile of long non-coding RNAs in Peripheral blood mononuclear cells from patients with neuropsychiatric systemic lupus erythematosus. 61
32355793 2020
40
Validation of the new classification criteria for hereditary recurrent fever in an independent cohort: experience from the JIR Cohort Database. 61
32125423 2020
41
Recurrence of Symptoms Associated with Menstruation in a Patient with a History of Periodic Fevers. 61
32224248 2020
42
Nanocellulose-Based Patches Loaded with Hyaluronic Acid and Diclofenac towards Aphthous Stomatitis Treatment. 61
32231070 2020
43
Gene variability in matrix metalloproteinases in patients with recurrent aphthous stomatitis. 61
31968135 2020
44
[Clinical phenotype and immunological features of a patient with A20 haploinsufficiency]. 61
32135594 2020
45
Regulation of DNA methylation levels in the process of oral mucosal regeneration in a rat oral ulcer model. 61
31286466 2020
46
Validation of the HADS and PSS-10 and a cross-sectional study of psychological status in patients with recurrent aphthous stomatitis. 61
31919894 2020
47
Behçet's disease with invasive pulmonary aspergillosis and Aspergillus auriculatus infection: A case report. 61
32028403 2020
48
Wound Healing Promoting Activity of Tonsil-Derived Stem Cells on 5-Fluorouracil-Induced Oral Mucositis Model. 61
32002842 2020
49
Mean Platelet Volume, Neutrophil-To-Lymphocyte Ratio, and Platelet-To-Lymphocyte Ratio as İnflammatory Markers in patients with Recurrent Aphthous Stomatitis. 61
32158312 2020
50
Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis. 61
31846848 2020

Variations for Aphthous Stomatitis

Expression for Aphthous Stomatitis

Search GEO for disease gene expression data for Aphthous Stomatitis.

Pathways for Aphthous Stomatitis

Pathways related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.14 TNF TLR4 TLR2 NLRP3 MEFV IL6
2
Show member pathways
13.98 TNF IL6 IL4 IL2 IL1B IL1A
3
Show member pathways
13.86 TNF TLR4 IL6 IL4 IL2 IL1RN
4
Show member pathways
13.7 TNF IL6 IL4 IL2 IL1B IL1A
5
Show member pathways
13.61 TNF TLR4 TLR2 IL6 IL4 IL2
6
Show member pathways
13.51 TNF IL6 IL4 IL2 IL1B IL1A
7
Show member pathways
13.5 TNF IL6 IL4 IL2 IL1RN IL1B
8
Show member pathways
13.39 TNF TLR4 TLR2 IL4 IL2 IL1B
9
Show member pathways
13.29 TNF TLR4 TLR2 IL6 IL2 IL1B
10
Show member pathways
13.18 TNF TLR4 TLR2 IL6 IL4 IL2
11
Show member pathways
13.16 TNF TLR4 TLR2 IL6 IL1B HLA-B
12
Show member pathways
13.04 TNF IL6 IL4 IL2 IL1B IL1A
13 12.99 TNF TLR2 IL6 IL1B IFNG HLA-B
14
Show member pathways
12.96 TNF TLR4 TLR2 NLRP3 IL6 IL1RN
15
Show member pathways
12.94 TNF TLR4 TLR2 IL6 IL2 IL1B
16
Show member pathways
12.84 TNF IL4 IL2 IL18 IL10 IFNG
17
Show member pathways
12.83 TNF TLR4 TLR2 IL6 IL4 IL2
18
Show member pathways
12.82 TNF TLR4 TLR2 IL6 IL4 IL2
19 12.81 TNF TLR2 IL4 IL2 IL1RN IL1B
20
Show member pathways
12.8 TNF IL6 IL2 IL1B IL18 IL10
21
Show member pathways
12.77 TNF IL1B IL1A IFNG CD40
22
Show member pathways
12.77 TNF TLR4 TLR2 IL1B IL1A CD40
23
Show member pathways
12.74 TNF IL4 IL2 IFNG HLA-B HLA-A
24
Show member pathways
12.64 IL6 IL4 IL2 IL10 IFNG CSF2
25 12.64 TNF TLR4 NLRP3 IL1B IL18 CXCL8
26
Show member pathways
12.6 TNF TLR2 IL6 IL4 IL1B IFNG
27 12.59 TNF IL6 IL2 HLA-B HLA-A CSF2
28 12.57 TNF TLR4 TLR2 NLRP3 IL6 IL1B
29
Show member pathways
12.56 TNF TLR4 IL6 IL1B IL1A IFNG
30
Show member pathways
12.54 TNF IL6 IL2 IL18 IL10 CXCL8
31
Show member pathways
12.54 TNF IL6 IL4 IL2 IL1B IFNG
32 12.53 TNF TLR4 NLRP3 IL6 IL1B IL18
33
Show member pathways
12.51 TNF TLR4 TLR2 IL4 IL1B IL1A
34 12.5 TNF TLR4 NLRP3 MEFV IL6 IL1B
35
Show member pathways
12.48 TNF TLR4 TLR2 IL6 IL1A CXCL8
36 12.48 TNF TLR4 TLR2 IL6 IL1B IL1A
37
Show member pathways
12.45 TNF TLR4 TLR2 IL6 IL4 IL1B
38
Show member pathways
12.44 TNF NLRP3 IL6 IL2 IL1B IL10
39 12.44 TNF IL6 IL1RN IL1B IL1A IL10
40
Show member pathways
12.43 TNF TLR4 NLRP3 IL1B IL1A IFNG
41 12.38 TNF TLR4 TLR2 IL6 IFNG
42 12.37 IL6 CXCL8 CSF2 CD40
43 12.35 IL6 IL1A HLA-B HLA-A CXCL8
44 12.27 TNF IL6 IL4 IL2 IL10 IFNG
45 12.26 TLR4 TLR2 HLA-B HLA-A
46 12.25 TNF IL6 IL4 IL1B IL1A IL18
47
Show member pathways
12.24 TLR4 TLR2 IL2 IL1B IL1A
48
Show member pathways
12.24 IL4 IL2 IL1B IL18 IFNG HLA-A
49 12.22 TNF IL1B IL1A IFNG
50 12.21 TNF TLR4 IL6 IL4 IL2 IL1B

GO Terms for Aphthous Stomatitis

Cellular components related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 TNF NLRP3 IL6 IL4 IL2 IL1RN
2 cell surface GO:0009986 9.63 TNF TLR4 TLR2 HLA-B HLA-A CD40
3 extracellular space GO:0005615 9.47 TNF IL6 IL4 IL2 IL1RN IL1B
4 phagocytic vesicle membrane GO:0030670 9.43 TLR2 HLA-B HLA-A
5 MHC class I protein complex GO:0042612 9.32 HLA-B HLA-A

Biological processes related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.4 TLR4 TLR2 NLRP3 IL6 IL4 IL1RN
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.27 TNF TLR4 TLR2 NLRP3 IL6 IL4
3 immune system process GO:0002376 10.25 TLR4 TLR2 NLRP3 MEFV IL2 HLA-B
4 innate immune response GO:0045087 10.22 TLR4 TLR2 NLRP3 MEFV HLA-B HLA-A
5 positive regulation of cell proliferation GO:0008284 10.21 IL6 IL4 IL2 IL1B IFNG CSF2
6 negative regulation of cell proliferation GO:0008285 10.18 TLR2 IL6 IL1B IL1A IL10 CXCL8
7 positive regulation of gene expression GO:0010628 10.16 TNF TLR4 TLR2 IL6 IL4 IL1B
8 MAPK cascade GO:0000165 10.12 TNF IL2 IL1B IL18 CSF2
9 regulation of immune response GO:0050776 10.09 IL4 HLA-B HLA-A CD40
10 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.08 TNF TLR4 IL1B IL1A CD40
11 positive regulation of protein phosphorylation GO:0001934 10.08 TNF IL2 IL1B IFNG CD40
12 defense response to virus GO:0051607 10.07 NLRP3 IL6 IFNG CD40
13 response to lipopolysaccharide GO:0032496 10.06 TLR4 TLR2 IL1B IL10
14 defense response GO:0006952 10.05 TNF NLRP3 HLA-B CXCL8
15 positive regulation of angiogenesis GO:0045766 10.05 IL1B IL1A CXCL8 CD40
16 negative regulation of inflammatory response GO:0050728 10.04 NLRP3 MEFV IL4 IL2 IL10
17 positive regulation of DNA-binding transcription factor activity GO:0051091 10.03 TNF IL6 IL1B IL10
18 defense response to Gram-positive bacterium GO:0050830 10.03 TNF TLR2 NLRP3 IL6 HLA-A
19 cytokine-mediated signaling pathway GO:0019221 10 TNF IL6 IL4 IL2 IL1RN IL1B
20 response to glucocorticoid GO:0051384 9.97 TNF IL6 IL1RN IL10
21 positive regulation of T cell proliferation GO:0042102 9.97 IL6 IL4 IL2 IL1B
22 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.97 TNF TLR4 TLR2 IL1B IL18
23 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 TNF TLR4 TLR2 NLRP3 IL6 IL1B
24 interferon-gamma-mediated signaling pathway GO:0060333 9.96 IFNG HLA-B HLA-A
25 regulation of insulin secretion GO:0050796 9.96 TNF IL1B IFNG
26 positive regulation of interleukin-6 production GO:0032755 9.96 TNF TLR4 TLR2 IL6 IL1B
27 cellular response to organic cyclic compound GO:0071407 9.95 TNF IL1B IL18
28 positive regulation of smooth muscle cell proliferation GO:0048661 9.95 TNF IL6 IL18
29 positive regulation of interferon-gamma production GO:0032729 9.95 TNF TLR4 IL2 IL1B IL18 HLA-A
30 positive regulation of inflammatory response GO:0050729 9.95 TNF TLR4 TLR2 IL2 IL1B IL18
31 humoral immune response GO:0006959 9.94 TNF IL6 IFNG
32 positive regulation of nitric oxide biosynthetic process GO:0045429 9.94 TNF TLR4 IL1B IFNG
33 positive regulation of B cell proliferation GO:0030890 9.94 TLR4 IL4 IL2 CD40
34 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.93 TNF IL1B IL1A CSF2
35 positive regulation of phagocytosis GO:0050766 9.92 TNF IL1B IFNG
36 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.92 IL4 IL2 IL1B IL1A
37 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.92 TNF IL6 IL4 IL2 IL18 IFNG
38 protein kinase B signaling GO:0043491 9.91 TNF IL1B CD40
39 negative regulation of interleukin-6 production GO:0032715 9.91 TNF TLR4 IL10
40 positive regulation of cytokine secretion GO:0050715 9.91 TNF IL1A IL10 IFNG
41 microglial cell activation GO:0001774 9.91 TNF TLR2 IL4 IFNG
42 lipopolysaccharide-mediated signaling pathway GO:0031663 9.91 TNF TLR4 TLR2 IL1B IL18
43 positive regulation of interleukin-6 secretion GO:2000778 9.91 TNF TLR4 TLR2 IL1B IL1A IFNG
44 positive regulation of JAK-STAT cascade GO:0046427 9.9 TNF IL6 IL10
45 positive regulation of vascular endothelial growth factor production GO:0010575 9.9 IL6 IL1B IL1A
46 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.9 HLA-B HLA-A ACE
47 positive regulation of interleukin-8 production GO:0032757 9.9 TNF TLR4 TLR2 IL1B
48 negative regulation of neurogenesis GO:0050768 9.89 TNF IL6 IL1B
49 positive regulation of interleukin-12 production GO:0032735 9.89 TLR4 TLR2 IFNG CD40
50 positive regulation of interleukin-10 production GO:0032733 9.88 TLR4 TLR2 IL4

Molecular functions related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.23 TNF TLR4 TLR2 NLRP3 MEFV IL6
2 cytokine activity GO:0005125 9.4 TNF IL6 IL4 IL2 IL1RN IL1B
3 lipopolysaccharide receptor activity GO:0001875 9.37 TLR4 TLR2
4 growth factor activity GO:0008083 9.35 IL6 IL4 IL2 IL10 CSF2
5 interleukin-1 receptor binding GO:0005149 9.33 IL1RN IL1B IL1A
6 TAP binding GO:0046977 9.32 HLA-B HLA-A

Sources for Aphthous Stomatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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