Apical Myocardial Infarction disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: APC001 MIFTS: 29	Apical Myocardial Infarction Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Apical Myocardial Infarction

MalaCards integrated aliases for Apical Myocardial Infarction:

Name: Apical Myocardial Infarction ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5848

NCIt ⁵¹ C36073

UMLS ⁷⁴ C3642319

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Summaries for Apical Myocardial Infarction

MalaCards based summary : Apical Myocardial Infarction is related to myocardial infarction and ovarian cancer 1. An important gene associated with Apical Myocardial Infarction is LEFTY2 (Left-Right Determination Factor 2), and among its related pathways/superpathways are GPCR Pathway and Integrin Pathway. Affiliated tissues include heart, lung and breast, and related phenotypes are neoplasm and respiratory system

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Related Diseases for Apical Myocardial Infarction

Diseases related to Apical Myocardial Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)

#	Related Disease	Score	Top Affiliating Genes
1	myocardial infarction	10.5
2	ovarian cancer 1	10.0	AKT1 MMP2
3	posterolateral myocardial infarction	10.0	KANTR PLG
4	malignant ovarian surface epithelial-stromal neoplasm	10.0	AKT1 MMP2
5	alk-negative anaplastic large cell lymphoma	10.0	BCL2L1 STAT3
6	acute anterolateral myocardial infarction	10.0	KANTR PLG
7	facial neuralgia	10.0	KANTR PLG
8	tabes dorsalis	10.0	KANTR LEFTY2
9	cerebral falx meningioma	10.0	KANTR PLG
10	cerebral arteritis	10.0	KANTR PLG
11	leech infestation	9.9	KANTR PLG
12	mitral valve insufficiency	9.9
13	alveolar periostitis	9.9	KANTR PLG
14	spastic entropion	9.9	KANTR MMP2
15	supratentorial cancer	9.9	AKT1 MMP2 STAT3
16	cerebrum cancer	9.9	AKT1 MMP2 STAT3
17	anteroseptal myocardial infarction	9.9	KANTR PLG
18	ovary epithelial cancer	9.9	AKT1 MMP2
19	respiratory system cancer	9.9	AKT1 MMP2 STAT3
20	senile ectropion	9.9	KANTR MMP2
21	anterior cranial fossa meningioma	9.9	KANTR PLG
22	gastrointestinal system cancer	9.9	AKT1 MMP2 STAT3
23	endocrine gland cancer	9.9	AKT1 MMP2 STAT3
24	brown-sequard syndrome	9.9	KANTR PLG
25	tertiary neurosyphilis	9.9	KANTR LEFTY2
26	breast adenocarcinoma	9.9	AKT1 BCL2L1 MMP2
27	gastrointestinal system disease	9.9	AKT1 MMP2 STAT3
28	anterior spinal artery syndrome	9.9	KANTR PLG
29	lateral medullary syndrome	9.9	KANTR PLG
30	mantle cell lymphoma	9.8	AKT1 BCL2L1 STAT3
31	carotid artery dissection	9.8	KANTR PLG
32	serous cystadenocarcinoma	9.8	AKT1 MMP2
33	myeloma, multiple	9.8	AKT1 BCL2L1 STAT3
34	nervous system disease	9.7	AKT1 KANTR PLG
35	nasopharyngeal carcinoma	9.7	AKT1 BCL2L1 STAT3
36	squamous cell carcinoma, head and neck	9.6	AKT1 BCL2L1 MMP2 STAT3
37	large intestine cancer	9.6	AKT1 BCL2L1 MMP2 STAT3
38	gastric adenocarcinoma	9.6	AKT1 BCL2L1 MMP2 STAT3
39	lung cancer susceptibility 3	9.6	AKT1 BCL2L1 MMP2 STAT3
40	esophageal cancer	9.6	AKT1 BCL2L1 MMP2 STAT3
41	leukemia, acute myeloid	9.5	AKT1 BCL2L1 PTPA STAT3

Graphical network of the top 20 diseases related to Apical Myocardial Infarction:

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Symptoms & Phenotypes for Apical Myocardial Infarction

MGI Mouse Phenotypes related to Apical Myocardial Infarction:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.35	AKT1 BCL2L1 MMP2 PLG STAT3
2	respiratory system	MP:0005388	9.02	AKT1 LEFTY2 MMP2 PLG STAT3

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Drugs & Therapeutics for Apical Myocardial Infarction

Search Clinical Trials , NIH Clinical Center for Apical Myocardial Infarction

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Genetic Tests for Apical Myocardial Infarction

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Anatomical Context for Apical Myocardial Infarction

MalaCards organs/tissues related to Apical Myocardial Infarction:

⁴²

Heart, Lung, Breast, Ovary, Myeloid

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Publications for Apical Myocardial Infarction

Articles related to Apical Myocardial Infarction:

(show all 12)

#	Title	Authors	Year
1	Inhibition of the nitric oxide/cyclic guanosine monophosphate pathway limited the cardioprotective effect of post-conditioning in hearts with apical myocardial infarction. ( 26387613 )	Correa F...Zazueta C	2015
2	Apical myocardial infarction with bizarre coronary images mimicking left ventricular apical ballooning syndrome: a case report. ( 24716472 )	Nomura T...Tatsumi T	2014
3	Multiple cardiovascular complications in a patient with missed small apical myocardial infarction caused by a coronary artery thrombus of uncertain origin. ( 23797452 )	Kiedrowicz R...Ka?mierczak J	2013
4	Implantation of the right ventricular lead of an implantable cardioverter-defibrillator complicated by apical myocardial infarction. ( 22949541 )	Nishiyama N...Fukuda K	2012
5	Correlation between non-reversible thallium-201 myocardial perfusion defect and ECG criteria in the diagnosis of apical myocardial infarction. ( 15193828 )	Fiorina P...Astorri E	2004
6	Anteroseptal or apical myocardial infarction: a controversy addressed using delayed enhancement cardiovascular magnetic resonance imaging. ( 15347130 )	Selvanayagam JB...Neubauer S	2004
7	Acute apical myocardial infarction after blunt chest trauma incurred during a basketball game. ( 11355055 )	Moore JE	2001
8	Systolic anterior movement of mitral valve during acute apical myocardial infarction: An unusual mechanism of acute mitral regurgitation. ( 10588792 )	Di Chiara A...Fioretti PM	1999
9	Inaccuracy of various proposed electrocardiographic criteria in the diagnosis of apical myocardial infarction--a critical review. ( 2598944 )	Giannuzzi P...Tavazzi L	1989
10	Insensitivity of the electrocardiogram in apical myocardial infarction. ( 6702618 )	Rothfeld B...Gottlieb SH	1984
11	Vectorcardiographic assessment of anterior and apical myocardial infarction. ( 6447738 )	Port S...Wagner GS	1980
12	The spatial vectorcardiogram and ventricular gradient in apical myocardial infarction in necropsied patients. ( 13815992 )	DEPASQUALE NP...BURCH GE	1960

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Genes for Apical Myocardial Infarction

Genes related to Apical Myocardial Infarction (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	LEFTY2	Left-Right Determination Factor 2	Protein Coding	16.26	DISEASES inferred ¹⁵
2	SRI	Sorcin	Protein Coding	15.44	DISEASES inferred ¹⁵
3	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	13.57	DISEASES inferred ¹⁵
4	PLG	Plasminogen	Protein Coding	13.41	DISEASES inferred ¹⁵
5	MMP2	Matrix Metallopeptidase 2	Protein Coding	13.34	DISEASES inferred ¹⁵
6	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	13.24	DISEASES inferred ¹⁵
7	PTPA	Protein Phosphatase 2 Phosphatase Activator	Protein Coding	4.59	DISEASES inferred ¹⁵
8	KANTR	KDM5C Adjacent Transcript	RNA Gene	3.73	DISEASES inferred ¹⁵
9	BCL2L1	BCL2 Like 1	Protein Coding	3.63	DISEASES inferred ¹⁵

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Variations for Apical Myocardial Infarction

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Expression for Apical Myocardial Infarction

Search GEO for disease gene expression data for Apical Myocardial Infarction.

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Pathways for Apical Myocardial Infarction

Pathways related to Apical Myocardial Infarction according to GeneCards Suite gene sharing:

(show all 44)

#	Super pathways	Score	Top Affiliating Genes
1	GPCR Pathway ⁶⁵ Show member pathways Breast Cancer Regulation by Stathmin1 ⁶⁵ Estrogen Pathway ⁶⁵ NFAT in Immune Response ⁶⁵ P2Y Receptor Signaling ⁶⁵ Pancreatic Adenocarcinoma ⁶⁵ Paxillin Interactions ⁶⁵ Ras Pathway ⁶⁵	13.49	AKT1 BCL2L1 LEFTY2 MMP2 PTPA STAT3
2	Integrin Pathway ⁶⁵ Show member pathways FAK1 Signaling ⁶⁵ GnRH Signaling ⁶⁵ Inhibition of Angiogenesis by TSP1 ⁶⁵ Transendothelial Migration of Leukocytes ⁶⁵ UPA-UPAR Pathway ⁶⁵	13.19	AKT1 LEFTY2 MMP2 PLG STAT3
3	p70S6K Signaling ⁶⁵ Show member pathways mTOR Pathway ⁶⁵ Renin-Angiotensin Pathway ⁶⁵	12.86	AKT1 LEFTY2 PTPA STAT3
4	Pathways in cancer ³⁸	12.63	AKT1 BCL2L1 MMP2 STAT3
5	Glioma ³⁸ Show member pathways Endocrine resistance ³⁸ Melanoma ³⁸ Non-small cell lung cancer ³⁸ Signaling Pathways in Glioblastoma ¹	12.47	AKT1 BCL2L1 MMP2 STAT3
6	4-1BB Pathway ⁶⁵ Show member pathways CD27 Pathway ⁶⁵ CD40 Signaling ⁶⁵ CMV and MAPK Pathways ⁶⁵ NF-KappaB Activation by EBV ⁶⁵ NF-kappaB Activation by Viruses ⁶⁵ PKR Pathway ⁶⁵ SUMO Pathway ⁶⁵ TNFR2 Pathway ⁶⁵	12.47	AKT1 BCL2L1 PTPA STAT3
7	Prolactin Signaling Pathway ¹ ³⁸ Show member pathways Development Prolactin receptor signaling ²³ Leptin signaling pathway ¹	12.31	AKT1 BCL2L1 STAT3
8	Development Dopamine D2 receptor transactivation of EGFR ²³ Show member pathways Apoptosis and survival BAD phosphorylation ²³ BAD Phosphorylation ⁶⁵ Chemotaxis CXCR4 signaling pathway ²³ Development Alpha-2 adrenergic receptor activation of ERK ²³	12.31	AKT1 BCL2L1 PTPA STAT3
9	Development EGFR signaling pathway ²³ Show member pathways Development ERBB-family signaling ²³ EGF Pathway ⁶⁵ EGFR Signaling Pathway ⁶⁸ ErbB receptor signaling network ¹	12.26	AKT1 LEFTY2 MMP2 STAT3
10	JAK-STAT signaling pathway (KEGG) ⁶⁶ Show member pathways Interleukin-19, 20, 22, 24 ⁶⁷ JAK-STAT signaling pathway ³⁸	12.23	AKT1 BCL2L1 STAT3
11	Development IGF-1 receptor signaling ²³ Show member pathways IL-4 Signaling Pathway ¹ Immune response IL-4 signaling pathway ²³ Signal transduction AKT signaling ²³	12.23	AKT1 BCL2L1 STAT3
12	CNTF Signaling ⁶⁵ Show member pathways FLT3 Signaling ⁶⁵ IL-3 Pathway ⁶⁵ Nur77-Induced AICD in Macrophage ⁶⁵ OSM Pathway ⁶⁵	12.16	AKT1 BCL2L1 STAT3
13	Proteoglycans in cancer ³⁸	12.12	AKT1 MMP2 STAT3
14	Immune response IL-23 signaling pathway ²³ Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶⁵ Development Angiopoietin - Tie2 signaling ²³ Development PDGF signaling via STATs and NF-kB ²³ IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²³ Rac1/Pak1/p38/MMP-2 pathway ¹	12.09	AKT1 BCL2L1 MMP2 PLG STAT3
15	Toxoplasmosis ³⁸ Show member pathways Leishmaniasis ³⁸	12.08	AKT1 BCL2L1 STAT3
16	Kit receptor signaling pathway ¹ Show member pathways IL-3 Signaling Pathway ¹ Signaling events mediated by Stem cell factor receptor (c-Kit) ¹	11.98	AKT1 BCL2L1 STAT3
17	Transcription Androgen Receptor nuclear signaling ²³ Show member pathways Translation Non-genomic (rapid) action of Androgen Receptor ²³	11.93	AKT1 MMP2 STAT3
18	Signaling pathways regulating pluripotency of stem cells ³⁸	11.9	AKT1 LEFTY2 STAT3
19	Immune response IFN gamma signaling pathway ²³ Show member pathways IFN-gamma pathway ¹	11.85	AKT1 LEFTY2 PTPA STAT3
20	Insulin resistance ³⁸ Show member pathways protein O-[N-acetyl]-glucosylation ¹	11.77	AKT1 PTPA STAT3
21	AGE-RAGE signaling pathway in diabetic complications ³⁸	11.7	AKT1 MMP2 STAT3
22	Development EPO-induced Jak-STAT pathway ²³ Show member pathways EPO Receptor Signaling ¹ EPO signaling pathway ¹	11.67	AKT1 BCL2L1 STAT3
23	AGE/RAGE pathway ¹	11.45	AKT1 MMP2 STAT3
24	Photodynamic therapy-induced AP-1 survival signaling. ¹	11.4	BCL2L1 MMP2
25	Signaling events mediated by PTP1B ¹	11.39	AKT1 STAT3
26	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway ¹	11.36	AKT1 STAT3
27	Busulfan Pathway, Pharmacodynamics ⁶² Show member pathways Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs) ¹ FMO oxidises nucleophiles ⁶⁷	11.32	BCL2L1 STAT3
28	Hepatitis C and Hepatocellular Carcinoma ¹	11.32	AKT1 BCL2L1 STAT3
29	Interleukin-4 and 13 signaling ⁶⁷	11.31	AKT1 BCL2L1 MMP2 STAT3
30	amb2 Integrin signaling ¹	11.26	AKT1 MMP2 PLG
31	Cell Differentiation - Index ¹	11.25	LEFTY2 STAT3
32	IL-2 Gene Expression in Activated and Quiescent T-Cells ⁶⁵ Show member pathways TOB in T-Cell Signaling ⁶⁵	11.25	AKT1 LEFTY2 MMP2 STAT3
33	Colorectal Cancer Metastasis ⁶⁵	11.24	AKT1 BCL2L1 LEFTY2 MMP2 STAT3
34	G-protein signaling_Cross-talk between Ras-family GTPases ²³	11.23	AKT1 LEFTY2 STAT3
35	IL-10 Pathway ⁶⁵	11.21	BCL2L1 STAT3
36	IL-7 Signaling Pathway ¹ Show member pathways B-Cell Development ⁶⁵ IL-9 Signaling Pathway ¹	11.21	AKT1 BCL2L1 STAT3
37	14-3-3 and Regulation of BAD Activity ⁶⁵	11.16	AKT1 BCL2L1
38	Interleukin-11 Signaling Pathway ¹	11.14	AKT1 PTPA STAT3
39	Plasma membrane estrogen receptor signaling ¹	11.05	AKT1 MMP2
40	A-beta Pathways: Plaque Formation and APP Metabolism ⁶⁶	10.99	MMP2 PLG
41	Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics ⁶²	10.98	AKT1 BCL2L1
42	Regulation of Apoptosis by Parathyroid Hormone-related Protein ¹	10.96	AKT1 BCL2L1
43	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ⁶⁷	10.93	MMP2 PLG
44	TFs Regulate miRNAs related to cardiac hypertrophy ¹	10.64	AKT1 STAT3

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GO Terms for Apical Myocardial Infarction

Cellular components related to Apical Myocardial Infarction according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrion	GO:0005739	9.02	AKT1 BCL2L1 MMP2 SRI STAT3

Biological processes related to Apical Myocardial Infarction according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of apoptotic process	GO:0042981	9.58	AKT1 BCL2L1 LEFTY2
2	germ cell development	GO:0007281	9.37	AKT1 BCL2L1
3	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	9.32	AKT1 BCL2L1
4	apoptotic mitochondrial changes	GO:0008637	9.26	AKT1 BCL2L1
5	negative regulation of release of cytochrome c from mitochondria	GO:0090201	9.16	AKT1 BCL2L1
6	regulation of mitochondrial membrane permeability	GO:0046902	8.96	BCL2L1 STAT3
7	cytokine-mediated signaling pathway	GO:0019221	8.92	AKT1 BCL2L1 MMP2 STAT3

Molecular functions related to Apical Myocardial Infarction according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein homodimerization activity	GO:0042803	9.26	AKT1 BCL2L1 PTPA STAT3
2	protein phosphatase 2A binding	GO:0051721	8.62	AKT1 PTPA

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