MCID: APC001
MIFTS: 29

Apical Myocardial Infarction

Categories: Cardiovascular diseases

Aliases & Classifications for Apical Myocardial Infarction

MalaCards integrated aliases for Apical Myocardial Infarction:

Name: Apical Myocardial Infarction 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:5848
NCIt 51 C36073
UMLS 74 C3642319

Summaries for Apical Myocardial Infarction

MalaCards based summary : Apical Myocardial Infarction is related to myocardial infarction and ovarian cancer 1. An important gene associated with Apical Myocardial Infarction is LEFTY2 (Left-Right Determination Factor 2), and among its related pathways/superpathways are GPCR Pathway and Integrin Pathway. Affiliated tissues include heart, lung and breast, and related phenotypes are neoplasm and respiratory system

Related Diseases for Apical Myocardial Infarction

Diseases related to Apical Myocardial Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 myocardial infarction 10.5
2 ovarian cancer 1 10.0 AKT1 MMP2
3 posterolateral myocardial infarction 10.0 KANTR PLG
4 malignant ovarian surface epithelial-stromal neoplasm 10.0 AKT1 MMP2
5 alk-negative anaplastic large cell lymphoma 10.0 BCL2L1 STAT3
6 acute anterolateral myocardial infarction 10.0 KANTR PLG
7 facial neuralgia 10.0 KANTR PLG
8 tabes dorsalis 10.0 KANTR LEFTY2
9 cerebral falx meningioma 10.0 KANTR PLG
10 cerebral arteritis 10.0 KANTR PLG
11 leech infestation 9.9 KANTR PLG
12 mitral valve insufficiency 9.9
13 alveolar periostitis 9.9 KANTR PLG
14 spastic entropion 9.9 KANTR MMP2
15 supratentorial cancer 9.9 AKT1 MMP2 STAT3
16 cerebrum cancer 9.9 AKT1 MMP2 STAT3
17 anteroseptal myocardial infarction 9.9 KANTR PLG
18 ovary epithelial cancer 9.9 AKT1 MMP2
19 respiratory system cancer 9.9 AKT1 MMP2 STAT3
20 senile ectropion 9.9 KANTR MMP2
21 anterior cranial fossa meningioma 9.9 KANTR PLG
22 gastrointestinal system cancer 9.9 AKT1 MMP2 STAT3
23 endocrine gland cancer 9.9 AKT1 MMP2 STAT3
24 brown-sequard syndrome 9.9 KANTR PLG
25 tertiary neurosyphilis 9.9 KANTR LEFTY2
26 breast adenocarcinoma 9.9 AKT1 BCL2L1 MMP2
27 gastrointestinal system disease 9.9 AKT1 MMP2 STAT3
28 anterior spinal artery syndrome 9.9 KANTR PLG
29 lateral medullary syndrome 9.9 KANTR PLG
30 mantle cell lymphoma 9.8 AKT1 BCL2L1 STAT3
31 carotid artery dissection 9.8 KANTR PLG
32 serous cystadenocarcinoma 9.8 AKT1 MMP2
33 myeloma, multiple 9.8 AKT1 BCL2L1 STAT3
34 nervous system disease 9.7 AKT1 KANTR PLG
35 nasopharyngeal carcinoma 9.7 AKT1 BCL2L1 STAT3
36 squamous cell carcinoma, head and neck 9.6 AKT1 BCL2L1 MMP2 STAT3
37 large intestine cancer 9.6 AKT1 BCL2L1 MMP2 STAT3
38 gastric adenocarcinoma 9.6 AKT1 BCL2L1 MMP2 STAT3
39 lung cancer susceptibility 3 9.6 AKT1 BCL2L1 MMP2 STAT3
40 esophageal cancer 9.6 AKT1 BCL2L1 MMP2 STAT3
41 leukemia, acute myeloid 9.5 AKT1 BCL2L1 PTPA STAT3

Graphical network of the top 20 diseases related to Apical Myocardial Infarction:



Diseases related to Apical Myocardial Infarction

Symptoms & Phenotypes for Apical Myocardial Infarction

MGI Mouse Phenotypes related to Apical Myocardial Infarction:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.35 AKT1 BCL2L1 MMP2 PLG STAT3
2 respiratory system MP:0005388 9.02 AKT1 LEFTY2 MMP2 PLG STAT3

Drugs & Therapeutics for Apical Myocardial Infarction

Search Clinical Trials , NIH Clinical Center for Apical Myocardial Infarction

Genetic Tests for Apical Myocardial Infarction

Anatomical Context for Apical Myocardial Infarction

MalaCards organs/tissues related to Apical Myocardial Infarction:

42
Heart, Lung, Breast, Ovary, Myeloid

Publications for Apical Myocardial Infarction

Articles related to Apical Myocardial Infarction:

(show all 12)
# Title Authors Year
1
Inhibition of the nitric oxide/cyclic guanosine monophosphate pathway limited the cardioprotective effect of post-conditioning in hearts with apical myocardial infarction. ( 26387613 )
2015
2
Apical myocardial infarction with bizarre coronary images mimicking left ventricular apical ballooning syndrome: a case report. ( 24716472 )
2014
3
Multiple cardiovascular complications in a patient with missed small apical myocardial infarction caused by a coronary artery thrombus of uncertain origin. ( 23797452 )
2013
4
Implantation of the right ventricular lead of an implantable cardioverter-defibrillator complicated by apical myocardial infarction. ( 22949541 )
2012
5
Correlation between non-reversible thallium-201 myocardial perfusion defect and ECG criteria in the diagnosis of apical myocardial infarction. ( 15193828 )
2004
6
Anteroseptal or apical myocardial infarction: a controversy addressed using delayed enhancement cardiovascular magnetic resonance imaging. ( 15347130 )
2004
7
Acute apical myocardial infarction after blunt chest trauma incurred during a basketball game. ( 11355055 )
2001
8
Systolic anterior movement of mitral valve during acute apical myocardial infarction: An unusual mechanism of acute mitral regurgitation. ( 10588792 )
1999
9
Inaccuracy of various proposed electrocardiographic criteria in the diagnosis of apical myocardial infarction--a critical review. ( 2598944 )
1989
10
Insensitivity of the electrocardiogram in apical myocardial infarction. ( 6702618 )
1984
11
Vectorcardiographic assessment of anterior and apical myocardial infarction. ( 6447738 )
1980
12
The spatial vectorcardiogram and ventricular gradient in apical myocardial infarction in necropsied patients. ( 13815992 )
1960

Variations for Apical Myocardial Infarction

Expression for Apical Myocardial Infarction

Search GEO for disease gene expression data for Apical Myocardial Infarction.

Pathways for Apical Myocardial Infarction

Pathways related to Apical Myocardial Infarction according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 AKT1 BCL2L1 LEFTY2 MMP2 PTPA STAT3
2
Show member pathways
13.19 AKT1 LEFTY2 MMP2 PLG STAT3
3
Show member pathways
12.86 AKT1 LEFTY2 PTPA STAT3
4 12.63 AKT1 BCL2L1 MMP2 STAT3
5
Show member pathways
12.47 AKT1 BCL2L1 MMP2 STAT3
6
Show member pathways
12.47 AKT1 BCL2L1 PTPA STAT3
7
Show member pathways
12.31 AKT1 BCL2L1 STAT3
8
Show member pathways
12.31 AKT1 BCL2L1 PTPA STAT3
9
Show member pathways
12.26 AKT1 LEFTY2 MMP2 STAT3
10
Show member pathways
12.23 AKT1 BCL2L1 STAT3
11
Show member pathways
12.23 AKT1 BCL2L1 STAT3
12
Show member pathways
12.16 AKT1 BCL2L1 STAT3
13 12.12 AKT1 MMP2 STAT3
14
Show member pathways
12.09 AKT1 BCL2L1 MMP2 PLG STAT3
15
Show member pathways
12.08 AKT1 BCL2L1 STAT3
16
Show member pathways
11.98 AKT1 BCL2L1 STAT3
17
Show member pathways
11.93 AKT1 MMP2 STAT3
18 11.9 AKT1 LEFTY2 STAT3
19
Show member pathways
11.85 AKT1 LEFTY2 PTPA STAT3
20
Show member pathways
11.77 AKT1 PTPA STAT3
21 11.7 AKT1 MMP2 STAT3
22
Show member pathways
11.67 AKT1 BCL2L1 STAT3
23 11.45 AKT1 MMP2 STAT3
24 11.4 BCL2L1 MMP2
25 11.39 AKT1 STAT3
26 11.36 AKT1 STAT3
27
Show member pathways
11.32 BCL2L1 STAT3
28 11.32 AKT1 BCL2L1 STAT3
29 11.31 AKT1 BCL2L1 MMP2 STAT3
30 11.26 AKT1 MMP2 PLG
31 11.25 LEFTY2 STAT3
32
Show member pathways
11.25 AKT1 LEFTY2 MMP2 STAT3
33 11.24 AKT1 BCL2L1 LEFTY2 MMP2 STAT3
34 11.23 AKT1 LEFTY2 STAT3
35 11.21 BCL2L1 STAT3
36
Show member pathways
11.21 AKT1 BCL2L1 STAT3
37 11.16 AKT1 BCL2L1
38 11.14 AKT1 PTPA STAT3
39 11.05 AKT1 MMP2
40 10.99 MMP2 PLG
41 10.98 AKT1 BCL2L1
43 10.93 MMP2 PLG

GO Terms for Apical Myocardial Infarction

Cellular components related to Apical Myocardial Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.02 AKT1 BCL2L1 MMP2 SRI STAT3

Biological processes related to Apical Myocardial Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of apoptotic process GO:0042981 9.58 AKT1 BCL2L1 LEFTY2
2 germ cell development GO:0007281 9.37 AKT1 BCL2L1
3 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.32 AKT1 BCL2L1
4 apoptotic mitochondrial changes GO:0008637 9.26 AKT1 BCL2L1
5 negative regulation of release of cytochrome c from mitochondria GO:0090201 9.16 AKT1 BCL2L1
6 regulation of mitochondrial membrane permeability GO:0046902 8.96 BCL2L1 STAT3
7 cytokine-mediated signaling pathway GO:0019221 8.92 AKT1 BCL2L1 MMP2 STAT3

Molecular functions related to Apical Myocardial Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.26 AKT1 BCL2L1 PTPA STAT3
2 protein phosphatase 2A binding GO:0051721 8.62 AKT1 PTPA

Sources for Apical Myocardial Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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