MCID: APC001
MIFTS: 27

Apical Myocardial Infarction

Categories: Cardiovascular diseases

Aliases & Classifications for Apical Myocardial Infarction

MalaCards integrated aliases for Apical Myocardial Infarction:

Name: Apical Myocardial Infarction 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:5848
NCIt 50 C36073
UMLS 73 C3642319

Summaries for Apical Myocardial Infarction

MalaCards based summary : Apical Myocardial Infarction is related to myocardial infarction and ovarian cancer 1. An important gene associated with Apical Myocardial Infarction is LEFTY2 (Left-Right Determination Factor 2), and among its related pathways/superpathways are GPCR Pathway and Integrin Pathway. Affiliated tissues include heart, and related phenotypes are neoplasm and respiratory system

Related Diseases for Apical Myocardial Infarction

Diseases related to Apical Myocardial Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 myocardial infarction 10.4
2 ovarian cancer 1 10.2 AKT1 MMP2
3 malignant ovarian surface epithelial-stromal neoplasm 10.2 AKT1 MMP2
4 ovary epithelial cancer 10.1 AKT1 MMP2
5 serous cystadenocarcinoma 10.1 AKT1 MMP2
6 acute anterolateral myocardial infarction 9.9 KANTR PLG
7 posterolateral myocardial infarction 9.9 KANTR PLG
8 facial neuralgia 9.9 KANTR PLG
9 cerebral falx meningioma 9.9 KANTR PLG
10 tabes dorsalis 9.9 KANTR LEFTY2
11 cerebral arteritis 9.9 KANTR PLG
12 leech infestation 9.9 KANTR PLG
13 alveolar periostitis 9.9 KANTR PLG
14 anterior cranial fossa meningioma 9.8 KANTR PLG
15 spastic entropion 9.8 KANTR MMP2
16 anterior spinal artery syndrome 9.8 KANTR PLG
17 senile ectropion 9.8 KANTR MMP2
18 salivary gland cancer 9.8 AKT1 MMP2 STAT3
19 anteroseptal myocardial infarction 9.8 KANTR PLG
20 respiratory system cancer 9.8 AKT1 MMP2 STAT3
21 gastrointestinal system cancer 9.8 AKT1 MMP2 STAT3
22 brown-sequard syndrome 9.8 KANTR PLG
23 lateral medullary syndrome 9.8 KANTR PLG
24 carotid artery dissection 9.7 KANTR PLG
25 myeloma, multiple 9.6 AKT1 BCL2L1 STAT3
26 arteries, anomalies of 9.5 AKT1 KANTR PLG
27 cholangiocarcinoma 9.4 AKT1 MMP2 STAT3
28 squamous cell carcinoma, head and neck 9.2 AKT1 BCL2L1 MMP2 STAT3
29 lung cancer susceptibility 3 9.2 AKT1 BCL2L1 MMP2 STAT3
30 nasopharyngeal carcinoma 9.1 AKT1 BCL2L1 STAT3
31 esophageal cancer 9.1 AKT1 BCL2L1 MMP2 STAT3
32 cervical cancer 9.0 AKT1 MMP2 STAT3
33 leukemia, acute myeloid 9.0 AKT1 BCL2L1 PTPA STAT3
34 ovarian cancer 8.7 AKT1 BCL2L1 MMP2 STAT3

Graphical network of the top 20 diseases related to Apical Myocardial Infarction:



Diseases related to Apical Myocardial Infarction

Symptoms & Phenotypes for Apical Myocardial Infarction

MGI Mouse Phenotypes related to Apical Myocardial Infarction:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.35 AKT1 BCL2L1 MMP2 PLG STAT3
2 respiratory system MP:0005388 9.02 AKT1 LEFTY2 MMP2 PLG STAT3

Drugs & Therapeutics for Apical Myocardial Infarction

Search Clinical Trials , NIH Clinical Center for Apical Myocardial Infarction

Genetic Tests for Apical Myocardial Infarction

Anatomical Context for Apical Myocardial Infarction

MalaCards organs/tissues related to Apical Myocardial Infarction:

41
Heart

Publications for Apical Myocardial Infarction

Articles related to Apical Myocardial Infarction:

(show all 12)
# Title Authors Year
1
Inhibition of the nitric oxide/cyclic guanosine monophosphate pathway limited the cardioprotective effect of post-conditioning in hearts with apical myocardial infarction. ( 26387613 )
2015
2
Apical myocardial infarction with bizarre coronary images mimicking left ventricular apical ballooning syndrome: a case report. ( 24716472 )
2014
3
Multiple cardiovascular complications in a patient with missed small apical myocardial infarction caused by a coronary artery thrombus of uncertain origin. ( 23797452 )
2013
4
Implantation of the right ventricular lead of an implantable cardioverter-defibrillator complicated by apical myocardial infarction. ( 22949541 )
2012
5
Anteroseptal or apical myocardial infarction: a controversy addressed using delayed enhancement cardiovascular magnetic resonance imaging. ( 15347130 )
2004
6
Correlation between non-reversible thallium-201 myocardial perfusion defect and ECG criteria in the diagnosis of apical myocardial infarction. ( 15193828 )
2004
7
Acute apical myocardial infarction after blunt chest trauma incurred during a basketball game. ( 11355055 )
2001
8
Systolic anterior movement of mitral valve during acute apical myocardial infarction: An unusual mechanism of acute mitral regurgitation. ( 10588792 )
1999
9
Inaccuracy of various proposed electrocardiographic criteria in the diagnosis of apical myocardial infarction--a critical review. ( 2598944 )
1989
10
Insensitivity of the electrocardiogram in apical myocardial infarction. ( 6702618 )
1984
11
Vectorcardiographic assessment of anterior and apical myocardial infarction. ( 6447738 )
1980
12
The spatial vectorcardiogram and ventricular gradient in apical myocardial infarction in necropsied patients. ( 13815992 )
1960

Variations for Apical Myocardial Infarction

Expression for Apical Myocardial Infarction

Search GEO for disease gene expression data for Apical Myocardial Infarction.

Pathways for Apical Myocardial Infarction

Pathways related to Apical Myocardial Infarction according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 AKT1 BCL2L1 LEFTY2 MMP2 PTPA STAT3
2
Show member pathways
13.19 AKT1 LEFTY2 MMP2 PLG STAT3
3
Show member pathways
12.85 AKT1 LEFTY2 PTPA STAT3
4 12.62 AKT1 BCL2L1 MMP2 STAT3
5
Show member pathways
12.55 AKT1 BCL2L1 MMP2 STAT3
6
Show member pathways
12.45 AKT1 BCL2L1 STAT3
7
Show member pathways
12.31 AKT1 BCL2L1 PTPA STAT3
8
Show member pathways
12.3 AKT1 BCL2L1 STAT3
9
Show member pathways
12.26 AKT1 BCL2L1 STAT3
10
Show member pathways
12.26 AKT1 LEFTY2 MMP2 STAT3
11 12.12 AKT1 MMP2 STAT3
12
Show member pathways
12.09 AKT1 BCL2L1 MMP2 PLG STAT3
13
Show member pathways
12.08 AKT1 BCL2L1 STAT3
14
Show member pathways
11.97 AKT1 BCL2L1 STAT3
15
Show member pathways
11.92 AKT1 MMP2 STAT3
16 11.89 AKT1 LEFTY2 STAT3
17
Show member pathways
11.85 AKT1 LEFTY2 PTPA STAT3
18
Show member pathways
11.76 AKT1 PTPA STAT3
19 11.7 AKT1 MMP2 STAT3
20
Show member pathways
11.67 AKT1 BCL2L1 STAT3
21
Show member pathways
11.57 AKT1 BCL2L1 STAT3
22 11.43 AKT1 MMP2 STAT3
23 11.41 LEFTY2 PTPA
24 11.39 BCL2L1 MMP2
25 11.38 AKT1 STAT3
26 11.35 AKT1 STAT3
27
Show member pathways
11.31 BCL2L1 STAT3
28 11.31 AKT1 BCL2L1 MMP2 STAT3
29 11.29 AKT1 BCL2L1 STAT3
30 11.24 LEFTY2 STAT3
31 11.24 AKT1 BCL2L1 LEFTY2 MMP2 STAT3
32 11.23 AKT1 MMP2 PLG
33 11.2 BCL2L1 STAT3
34
Show member pathways
11.16 AKT1 BCL2L1 STAT3
35 11.15 AKT1 BCL2L1
36 11.08 AKT1 PTPA STAT3
37 11.05 AKT1 MMP2
38 10.98 MMP2 PLG
39 10.98 AKT1 BCL2L1
41 10.93 MMP2 PLG

GO Terms for Apical Myocardial Infarction

Cellular components related to Apical Myocardial Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.02 AKT1 BCL2L1 MMP2 SRI STAT3

Biological processes related to Apical Myocardial Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to amino acid stimulus GO:0071230 9.4 BCL2L1 MMP2
2 germ cell development GO:0007281 9.37 AKT1 BCL2L1
3 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.32 AKT1 BCL2L1
4 apoptotic mitochondrial changes GO:0008637 9.26 AKT1 BCL2L1
5 negative regulation of release of cytochrome c from mitochondria GO:0090201 9.16 AKT1 BCL2L1
6 regulation of mitochondrial membrane permeability GO:0046902 8.96 BCL2L1 STAT3
7 cytokine-mediated signaling pathway GO:0019221 8.92 AKT1 BCL2L1 MMP2 STAT3

Molecular functions related to Apical Myocardial Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.26 AKT1 BCL2L1 PTPA STAT3
2 protein phosphatase 2A binding GO:0051721 8.62 AKT1 PTPA

Sources for Apical Myocardial Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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