Aliases & Classifications for Apnea, Central Sleep

MalaCards integrated aliases for Apnea, Central Sleep:

Name: Apnea, Central Sleep 58



autosomal dominant


apnea, central sleep:
Clinical modifier sudden death
Inheritance autosomal dominant inheritance

External Ids:

OMIM 58 107640
MedGen 43 C0520680
SNOMED-CT via HPO 70 263681008 26636000 73430006

Summaries for Apnea, Central Sleep

MalaCards based summary : Apnea, Central Sleep is related to central sleep apnea and sleep apnea. An important gene associated with Apnea, Central Sleep is CHAT (Choline O-Acetyltransferase). The drugs Loperamide and Guaifenesin have been mentioned in the context of this disorder. Affiliated tissues include heart, eye and spinal cord, and related phenotype is sleep apnea.

Description from OMIM: 107640

Related Diseases for Apnea, Central Sleep

Diseases related to Apnea, Central Sleep via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 central sleep apnea 12.0
2 sleep apnea 10.6
3 rere-related disorders 10.2
4 congestive heart failure 10.0

Symptoms & Phenotypes for Apnea, Central Sleep

Human phenotypes related to Apnea, Central Sleep:

# Description HPO Frequency HPO Source Accession
1 sleep apnea 33 HP:0010535

Symptoms via clinical synopsis from OMIM:

infantile sleep apnea

frequent sudden infant death syndrome

Clinical features from OMIM:


Drugs & Therapeutics for Apnea, Central Sleep

Drugs for Apnea, Central Sleep (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 89)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Loperamide Approved Phase 4 53179-11-6 3955
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
Opium Approved, Illicit Phase 4 8008-60-4
Acetazolamide Approved, Vet_approved Phase 4,Phase 3 59-66-5 1986
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
tannic acid Approved Phase 4 1401-55-4
Finasteride Approved Phase 4 98319-26-7 57363
Testosterone Approved, Experimental, Investigational Phase 4 58-22-0, 481-30-1 10204 6013
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
Desflurane Approved Phase 4 57041-67-5 42113
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
Remifentanil Approved Phase 4 132875-61-7 60815
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
15 Natriuretic Agents Phase 4,Phase 3
16 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
17 Carbonic Anhydrase Inhibitors Phase 4,Phase 3
18 Analgesics Phase 4,Phase 3,Not Applicable
19 diuretics Phase 4,Phase 3
20 Gastrointestinal Agents Phase 4
21 Central Nervous System Depressants Phase 4,Phase 3,Not Applicable
22 Antitussive Agents Phase 4
23 Analgesics, Opioid Phase 4,Not Applicable
24 Respiratory System Agents Phase 4
25 Opium Poppy Phase 4
26 Narcotics Phase 4,Not Applicable
27 Antidiarrheals Phase 4
28 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
29 Anticonvulsants Phase 4,Phase 3
30 Tranquilizing Agents Phase 4,Phase 3
31 Serotonin Uptake Inhibitors Phase 4,Phase 3
32 Psychotropic Drugs Phase 4,Phase 3
33 Neurotransmitter Agents Phase 4,Phase 3
34 Antidepressive Agents, Second-Generation Phase 4,Phase 3
35 Anti-Anxiety Agents Phase 4,Phase 3
36 Antidepressive Agents Phase 4,Phase 3
37 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3
38 Serotonin Agents Phase 4,Phase 3
39 5-alpha Reductase Inhibitors Phase 4
40 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
41 Steroid Synthesis Inhibitors Phase 4
42 Hormone Antagonists Phase 4,Phase 2,Phase 3
43 Hormones Phase 4,Phase 2,Phase 3
44 Antipsychotic Agents Phase 4
45 Antiemetics Phase 4
46 Autonomic Agents Phase 4
47 Anesthetics, General Phase 4,Phase 3
48 Adjuvants, Anesthesia Phase 4
49 Platelet Aggregation Inhibitors Phase 4
50 Anesthetics, Intravenous Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 70)
# Name Status NCT ID Phase Drugs
1 Effect of Acetazolamide on Central Sleep Apnea Related to Opium Consumption Enrolling by invitation NCT02371473 Phase 4 Acetazolamide-placebo;Placebo-acetazolamide
2 Oxygen Versus Medical Air for Treatment of CSA in Prader Will Syndrome Recruiting NCT03031626 Phase 4
3 Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury Recruiting NCT02922894 Phase 4 Trazodone;Placebo
4 Sleep Apnea in Elderly Recruiting NCT02703220 Phase 4 Acetazolamide;Finasteride
5 An Investigation of the Sleep Architecture and Consequent Cognitive Changes in Olanzapine-Treated Depressed Patients Completed NCT00520507 Phase 4 Olanzapine;Placebo
6 Short Life Agents in Balanced Anesthesia on Obstructive Sleep Apnea Syndrome Completed NCT02717780 Phase 4 Fentanyl and sevoflurane;Remifentanil and desflurane
7 Assessment of Desogestrel in Ondine Syndrome Completed NCT01243697 Phase 2, Phase 3 desogestrel
8 Buspirone as a Potential Treatment for Recurrent Central Apnea Terminated NCT00746954 Phase 3 Acetazolamide;Buspirone
9 Efficacy of Fluoxetine Against Seizure-induced Central Apneas Completed NCT02569970 Phase 3 fluoxetine 20 mg;placebo 20 mg
10 Ketofol vs Propofol for Emergency Department Procedural Sedation and Analgesia Completed NCT01211158 Phase 3 Ketofol;Propofol alone
11 Caffeine for Apnea of Prematurity-Sleep (CAP-S) Study Completed NCT01020357 Phase 3 Caffeine citrate injection;placebo
12 Stroke and CPAP Outcome Study 2 Completed NCT02809430 Phase 2
13 Safety of Ramelteon in Subjects With Mild to Moderate Obstructive Sleep Apnea Completed NCT00672061 Phase 2 Ramelteon or Placebo
14 Effect of Fenofibrate on Sleep Apnea Syndrome Terminated NCT00816829 Phase 2 Placebo;Fenofibrate
15 Pathophysiology of Central Apnoeas in Stroke Patients Unknown status NCT01723189
16 Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study D Unknown status NCT01733784 Not Applicable
17 PHOX2B Mutation-Confirmed Congenital Central Hypoventilation Syndrome in A Chinese Family: Presentations From Newborn to Adulthood Unknown status NCT00652964
18 Intrinsic Periodic Pattern of Breathing Unknown status NCT02201875
19 Normal Polysomnography Values in Healthy Children and Adolescents in China Unknown status NCT02761902
20 PAC-IC-SAS Pilot Study - Central Sleep Apneas Syndrome and Ventricular Function Completed NCT01741337 Not Applicable
21 Brainstem Dysfunction Involvement in the Pathogenesis of Pierre Robin Sequence Recruiting NCT03423017 Not Applicable
22 Central Apnea in Patients Receiving Ticagrelor Recruiting NCT03540459
23 Quality of Sleep of Patients With Predominant Central Sleep Apnea Syndrome(SAS) Whose EF > 45% Treated by ASV Recruiting NCT02835638
24 Bipap Automatic Servo Ventilation (autoSV) Advanced in Central Apnea Patients Completed NCT01199042 Not Applicable
25 Comparison of CPAP With SOMNOventCR in Patients With Underlying Heart Disease, Combined OSA and CSR Completed NCT00811668 Not Applicable
26 Comparison of Breathing Event Detection by a Continuous Positive Airway Pressure Device to Clinical Polysomnography Completed NCT01175031 Not Applicable
27 Pathophysiological Study of CSA in Adults With pLVEF Not yet recruiting NCT03919344 Not Applicable
28 Cognitive Consequences of an Activation of the Cortical Drive to Breath (VENTIPSY) Recruiting NCT03095729
29 Different Loop Gain Phenotypes in Patients With Chronic Systolic Heart Failure and Periodic Breathing Completed NCT03532412
30 Incidence of Sleep-disordered Breathing and Upper Airway Collapsibility in Postpartum Patients and Its Intervention Completed NCT01719224 Not Applicable
31 The remedē® System for the Treatment of Central Sleep Apnea in Daily Practice Terminated NCT02577445
32 Respiratory Drive in Patients With Univentricular Congenital Heart Disease Recruiting NCT03818373 Not Applicable
33 Eval EarlySense Bet Lowenstein Sleeplab Withdrawn NCT01978340
34 Validation of a New Automatic Bi-level Algorithm in the Treatment of Sleep-disordered Breathing Completed NCT00910195 Not Applicable
35 Alice PDx User/Validation Extended Trial Completed NCT00841906 Not Applicable
36 Minimally Invasive Detection of a Sleep Apnoea Enrolling by invitation NCT03760159
37 Effect of Oxygen on Core Temperature Completed NCT00543452 Not Applicable
38 Arterial Oxygen Saturation on Ventilatory Stability in Extremely Premature Infants Recruiting NCT03695900 Not Applicable
39 Diagnosis of Sleep-Related Respiratory Disorders in Patients With Narcotic Medications Not yet recruiting NCT03670914 Not Applicable
40 The Influence of the Sleep Apnea on the Neurological and Functional Recovery Completed NCT01321229
41 Evaluation of Breathing, Sleep and the Effects of Continuous Positive Airway Pressure During Wakefulness in Children With Heart Failure Completed NCT02414126 Not Applicable
42 Evaluation of ApneaLink Plus Scoring Capabilities Completed NCT00823134
43 Benefit of Cheyne-Stokes Respiration Remote Monitoring in CPAP-treated Patients With Obstructive Sleep Apnea to Detect Early Events of Heart Failure. Enrolling by invitation NCT03592108 Not Applicable
44 Servo-Ventilation In-lab PSG Evaluation Completed NCT02808338 Not Applicable
45 Randomized Trial Investigating Four Nasal CPAP Systems in the Management of Apnea of Prematurity Terminated NCT00482040 Not Applicable
46 Role of Obstructive Sleep Apnea in Stroke Appearance Completed NCT00613522
47 Incidence and Nature of Respiratory Impairment in Consecutive Patients Undergoing Bronchoscopy Under Conscious Sedation: A Pilot Study Recruiting NCT03886454
48 Determinants of Age Related Breathing Instability During Non-Rapid-Eye-Movement (NREM) Sleep Completed NCT00732199 Not Applicable
49 Sleep Disordered Breathing and Chronic Pain Completed NCT01457014 Not Applicable
50 Transcutaneous CO2 Monitoring at Home for Children With Neuromuscular Disease Recruiting NCT03478566 Not Applicable

Search NIH Clinical Center for Apnea, Central Sleep

Genetic Tests for Apnea, Central Sleep

Anatomical Context for Apnea, Central Sleep

MalaCards organs/tissues related to Apnea, Central Sleep:

Heart, Eye, Spinal Cord

Publications for Apnea, Central Sleep

Articles related to Apnea, Central Sleep:

# Title Authors Year
Clinical impact of adaptive servoventilation compared to other ventilatory modes in patients with treatment-emergent sleep apnea, central sleep apnea and Cheyne-Stokes respiration. ( 25926251 )

Variations for Apnea, Central Sleep

ClinVar genetic disease variations for Apnea, Central Sleep:

# Gene Variation Type Significance SNP ID Assembly Location
1 CHAT NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys) single nucleotide variant Pathogenic rs201439531 GRCh38 Chromosome 10, 49664880: 49664880
2 CHAT NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys) single nucleotide variant Pathogenic rs201439531 GRCh37 Chromosome 10, 50872926: 50872926
3 CHAT NM_020549.4(CHAT): c.1061C> T (p.Thr354Met) single nucleotide variant Conflicting interpretations of pathogenicity rs769234940 GRCh38 Chromosome 10, 49627735: 49627735
4 CHAT NM_020549.4(CHAT): c.1061C> T (p.Thr354Met) single nucleotide variant Conflicting interpretations of pathogenicity rs769234940 GRCh37 Chromosome 10, 50835781: 50835781

Expression for Apnea, Central Sleep

Search GEO for disease gene expression data for Apnea, Central Sleep.

Pathways for Apnea, Central Sleep

GO Terms for Apnea, Central Sleep

Sources for Apnea, Central Sleep

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
33 HPO
34 ICD10
35 ICD10 via Orphanet
39 LifeMap
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
56 Novoseek
59 OMIM via Orphanet
63 PubMed
71 SNOMED-CT via Orphanet
73 Tocris
75 UMLS via Orphanet
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