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OSA
MCID: APN008
MIFTS: 67

Apnea, Obstructive Sleep (OSA)

Categories: Neuronal diseases, Mental diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Apnea, Obstructive Sleep

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MalaCards integrated aliases for Apnea, Obstructive Sleep:

Name: Apnea, Obstructive Sleep 57
Obstructive Sleep Apnea 12 76 25 15 63
Obstructive Sleep Apnea Syndrome 57 12 25 29
Upper Airway Resistance Sleep Apnea Syndrome 25 73
Sleep Apnea/hypopnea Syndrome 57 25
Sleep Apnea, Obstructive 25 73
Sleep Apnea Syndromes 44 73
Osas 57 25
Sahs 57 25
Osa 57 25
Sleep Apnea/hypopnea Syndrome; Sahs; Osahs 57
Obstructive Sleep Apnea Syndrome; Osas 57
Sleep Apnea Syndrome, Obstructive 25
Sleep Apnea Hypopnea Syndrome 25
Sleep Apnea Obstructive 55
Apnea, Obstructive 25
Obstructive Apnea 25
Osahs 25

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
apnea, obstructive sleep:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Mental diseases
See all MalaCards categories (disease lists)
ICD10: 33


Sources

Summaries for Apnea, Obstructive Sleep

About this section
PubMed Health : 63 About obstructive sleep apnea: We all know what it is like to feel tired after a sleepless night because of things like noise, worries or stress. But what if you do actually get enough sleep and still feel absolutely beat the next morning? This is normal for many people with obstructive sleep apnea (OSA): They do not get enough air while they are sleeping (but do not usually notice this), have breathing pauses, and feel very sleepy during the day. In the long term, this increases their risk of developing other illnesses and can have a huge effect on their quality of life.

MalaCards based summary : Apnea, Obstructive Sleep, also known as obstructive sleep apnea, is related to kawasaki disease and kidney disease, and has symptoms including apnea, back pain and cheyne-stokes respiration. An important gene associated with Apnea, Obstructive Sleep is LEP (Leptin), and among its related pathways/superpathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Folate Metabolism. The drugs Guanfacine and Hydrochlorothiazide have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and testes, and related phenotypes are anosmia and excessive daytime somnolence

OMIM : 57 Obstructive sleep apnea is a common, chronic, complex disease associated with serious cardiovascular and neuropsychologic sequelae and with substantial social and economic costs (Palmer et al., 2003). (107650)

Genetics Home Reference : 25 Obstructive sleep apnea is a condition in which individuals experience pauses in breathing (apnea) during sleep, which are associated with partial or complete closure of the throat (upper airway). Complete closure can lead to apnea while partial closure allows breathing but decrease the intake of oxygen (hypopnea).

Disease Ontology : 12 A sleep apnea that is characterized by repeated collapse and obstruction of the upper airway during sleep, which results in reduced airflow (hypopnea) or complete airflow cessation (apnea), oxygen desaturation, and arousals from sleep.

Wikipedia : 76 Obstructive sleep apnea (OSA) is the most common type of sleep apnea and is caused by complete or... more...

Sources

Related Diseases for Apnea, Obstructive Sleep

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Diseases related to Apnea, Obstructive Sleep via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 kawasaki disease 32.0 CRP IL6 TNF
2 kidney disease 29.0 CRP EDN1 INS REN
3 hypertension, essential 28.9 ADIPOQ CRP EDN1 INS LEP REN
4 sleep apnea 28.2 ADIPOQ CRP EDN1 HCRT HTR2A IL6
5 autoimmune encephalopathy with parasomnia and obstructive sleep apnea 12.3
6 central sleep apnea 12.0
7 3mc syndrome 2 11.4
8 acquired generalized lipodystrophy 11.0 ADIPOQ LEP
9 pierre robin syndrome 10.9
10 apnea of prematurity 10.9
11 idiopathic recurrent pericarditis 10.9 ADIPOQ LEP
12 malignant otitis externa 10.8 CRP INS
13 cold agglutinin disease 10.8 CRP IL6
14 scorpion envenomation 10.8 IL6 TNF
15 obesity-hypoventilation syndrome 10.7 ADIPOQ IL6 LEP
16 abdominal obesity-metabolic syndrome 1 10.7 ADIPOQ INS LEP
17 leukomalacia 10.7 IL6 TNF
18 endocrine pancreas disease 10.7 ADIPOQ INS LEP
19 nontuberculous mycobacterial lung disease 10.7 ADIPOQ LEP TNF
20 angioimmunoblastic lymphadenopathy with dysproteinemia 10.7 IL6 TNF
21 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.7 CRP INS LEP
22 arteriosclerosis obliterans 10.7 ADIPOQ HTR2A IL6
23 cryopyrin-associated periodic syndrome 10.7 CRP IL6
24 acanthosis nigricans 10.7 ADIPOQ INS LEP
25 3-hydroxyacyl-coa dehydrogenase deficiency 10.7 ADIPOQ INS LEP
26 critical limb ischemia 10.6 IL6 TNF
27 intermittent claudication 10.6 CRP HTR2A IL6
28 acute adrenal insufficiency 10.6 IL6 REN
29 protein-energy malnutrition 10.6 IL6 LEP TNF
30 coronary heart disease 1 10.6 ADIPOQ CRP INS
31 streptococcal toxic-shock syndrome 10.6 IL6 TNF
32 cardiogenic shock 10.5 CRP IL6
33 glucose intolerance 10.5 ADIPOQ INS LEP
34 central nervous system vasculitis 10.5 CRP IL6 TNF
35 louse-borne relapsing fever 10.5 CRP IL6 TNF
36 uremia 10.5 CRP INS LEP
37 systolic heart failure 10.5 CRP IL6 TNF
38 adult-onset still's disease 10.5 CRP IL6 TNF
39 perinatal necrotizing enterocolitis 10.5 CRP IL6 TNF
40 infective endocarditis 10.5 CRP IL6 TNF
41 hemorrhagic fever with renal syndrome 10.5 CRP IL6 TNF
42 lymph node disease 10.5 CRP IL6 TNF
43 lipodystrophy, familial partial, type 2 10.5 INS LEP
44 early-onset schizophrenia 10.5 HTR2A INS TNF
45 exanthem 10.5 CRP IL6 TNF
46 uterine anomalies 10.5 CRP IL6 TNF
47 anorexia nervosa 10.5 ADIPOQ HCRT HTR2A LEP
48 leptospirosis 10.5 CRP IL6 TNF
49 gestational diabetes 10.5 ADIPOQ INS LEP
50 pericarditis 10.5 CRP IL6 TNF

Graphical network of the top 20 diseases related to Apnea, Obstructive Sleep:



Diseases related to Apnea, Obstructive Sleep
Sources

Symptoms & Phenotypes for Apnea, Obstructive Sleep

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Symptoms via clinical synopsis from OMIM:

57
Resp:
obstructive sleep apnea
snoring

Misc:
hypersomnolence
restless movements during sleep

Neuro:
anosmia
partial complex seizures


Clinical features from OMIM:

107650

Human phenotypes related to Apnea, Obstructive Sleep:

32
# Description HPO Frequency HPO Source Accession
1 anosmia 32 HP:0000458
2 excessive daytime somnolence 32 HP:0001262
3 focal seizures with impairment of consciousness or awareness 32 HP:0002384
4 obstructive sleep apnea 32 HP:0002870
5 snoring 32 HP:0025267

UMLS symptoms related to Apnea, Obstructive Sleep:


apnea, back pain, cheyne-stokes respiration, coughing, dyspnea, headache, pain, sciatica, seizures, sleep disturbances, snoring, syncope, tremor, wheezing, chronic pain, vertigo/dizziness, labored breathing, excessive daytime somnolence, sleeplessness, insomnia with sleep apnea, unspecified, hypersomnia with sleep apnea, unspecified, disruption of 24 hour sleep wake cycle, unspecified

MGI Mouse Phenotypes related to Apnea, Obstructive Sleep:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.18 INS EDN1 ADIPOQ FXYD1 HCRT IL6
2 behavior/neurological MP:0005386 10.13 ADIPOQ HCRT HTR2A AHI1 CENPJ IL6
3 growth/size/body region MP:0005378 10.11 EDN1 ADIPOQ HCRT AHI1 CENPJ IL6
4 homeostasis/metabolism MP:0005376 10.1 CRP INS EDN1 ADIPOQ HCRT AHI1
5 immune system MP:0005387 10 CRP CTNNBL1 INS ADIPOQ AHI1 CENPJ
6 adipose tissue MP:0005375 9.93 ADIPOQ CENPJ IL6 INS TNF LEP
7 muscle MP:0005369 9.93 EDN1 ADIPOQ FXYD1 HCRT HTR2A IL6
8 renal/urinary system MP:0005367 9.56 INS EDN1 ADIPOQ AHI1 IL6 LEP
9 skeleton MP:0005390 9.23 EDN1 ADIPOQ HTR2A CENPJ IL6 INS
Sources

Drugs & Therapeutics for Apnea, Obstructive Sleep

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PubMedHealth treatment related to Apnea, Obstructive Sleep: 63

If you are very overweight, losing weight can help improve sleep apnea. There are also many treatment options that aim to relieve sleep apnea. These include machines that support breathing during the night, surgery, and special aids such as mouth guards. Some of these treatments have been scientifically proven to help people with sleep apnea. Medication is currently not used for the treatment of sleep apnea. There is no scientific evidence that the available medications work.The most effective treatment for severe sleep apnea is called CPAP therapy. CPAP stands for “continuous positive airway pressure.” In this treatment approach, air is taken from the immediate surroundings and blown into your airways at night using low pressure. While you sleep, you wear a breathing mask that is connected to a machine called a respirator. The pressure keeps the upper airways open. People who use this machine have fewer breathing pauses, or even none at all. This can noticeably improve the symptoms such as tiredness during the day. Common side effects include a dry throat and an irritated, sometimes blocked nose.

Drugs for Apnea, Obstructive Sleep (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 411)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
2
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
3
Nebivolol Approved, Investigational Phase 4 152520-56-4, 99200-09-6, 118457-14-0 71301
4
Donepezil Approved Phase 4 120014-06-4 3152
5
Amlodipine Approved Phase 4,Phase 2,Phase 3 88150-42-9 2162
6
Angiotensin II Approved, Investigational Phase 4,Phase 2,Not Applicable 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
7
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
8
Acetylcholine Approved Phase 4 51-84-3 187
9
Budesonide Approved Phase 4,Phase 3,Phase 1 51333-22-3 63006 5281004
10
Montelukast Approved Phase 4,Phase 3,Phase 2 158966-92-8 5281040
11
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 113775-47-6 68602 5311068
12
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 2078-54-8 4943
13
Nitric Oxide Approved Phase 4 10102-43-9 145068 160954
14
Morphine Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 57-27-2 5288826
15
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 437-38-7 3345
16
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 1994-09-7, 94-09-7 2337
17
Acetaminophen Approved Phase 4,Phase 3,Not Applicable 103-90-2 1983
18
Ibuprofen Approved Phase 4,Phase 3,Not Applicable 15687-27-1 3672
19
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
20
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
21
Armodafinil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 112111-43-0
22
Modafinil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 68693-11-8 4236
23
Sodium oxybate Approved Phase 4 502-85-2 5360545
24
Zolpidem Approved Phase 4 82626-48-0 5732
25
Acetazolamide Approved, Vet_approved Phase 4,Phase 2,Not Applicable 59-66-5 1986
26
Fluticasone Approved, Experimental, Investigational Phase 4,Phase 3,Not Applicable 90566-53-3 62924
27
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
28
Adalimumab Approved Phase 4 331731-18-1 16219006
29
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
30
Ephedrine Approved Phase 4,Not Applicable 299-42-3 9294
31
Pseudoephedrine Approved Phase 4,Not Applicable 90-82-4 7028
32
Xylometazoline Approved, Investigational Phase 4,Not Applicable 526-36-3 5709
33
Norepinephrine Approved Phase 4,Not Applicable 51-41-2 439260
34
Eplerenone Approved Phase 4 107724-20-9 150310 443872
35
Spironolactone Approved Phase 4,Not Applicable 1952-01-7, 52-01-7 5833
36
Eszopiclone Approved, Investigational Phase 4,Phase 2,Early Phase 1,Not Applicable 138729-47-2 969472
37
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
38
Remifentanil Approved Phase 4,Early Phase 1 132875-61-7 60815
39
Losartan Approved Phase 4,Phase 2 114798-26-4 3961
40
Pantoprazole Approved Phase 4 102625-70-7 4679
41
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
42
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 6740-88-1 3821
43
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
44
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Not Applicable 28523-86-6 5206
45
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Not Applicable 93-14-1 3516
46
Liraglutide Approved Phase 4,Phase 3 204656-20-2 44147092
47
Oxymetazoline Approved, Investigational Phase 4,Phase 3,Phase 2 1491-59-4 4636
48
Phenylephrine Approved Phase 4,Phase 3,Phase 2 59-42-7 6041
49
Pioglitazone Approved, Investigational Phase 4,Not Applicable 111025-46-8 4829
50
Progesterone Approved, Vet_approved Phase 4,Not Applicable 57-83-0 5994

Interventional clinical trials:

(show top 50) (show all 1398)
# Name Status NCT ID Phase Drugs
1 Cost-utility Study of Continuous Positive Airway Pressure Treatment in Obstructive Sleep Apnea Syndrome Patients Unknown status NCT01590420 Phase 4
2 Validation of Functional Imaging as Predictive Tool for Outcome of Mandibular Replacement Appliance Therapy in Obstructive Sleep Apnea Hypopnea Syndrome Patients Unknown status NCT01524510 Phase 4
3 PROMAD: Predicting Therapeutic Outcome of Mandibular Advancement Device Treatment in Obstructive Sleep Apnea Unknown status NCT01532050 Phase 4
4 A Randomized Cross Over Trial of Two Treatments for Obstructive Sleep Apnea in Veterans With Post Traumatic Stress Disorder Unknown status NCT01535586 Phase 4
5 Treatment of OSA Associated Hypertension With Alpha 2 Agonist or Diuretic Unknown status NCT02699125 Phase 4 Guanfacine;Hydrochlorothiazide
6 Comparison of the Pentax AWS® With the Macintosh Laryngoscopic Intubation in Obstructive Sleep Apnea Syndrome Patients Unknown status NCT01428570 Phase 4
7 CPAP and Nebivolol in Hypertensive Obstructive Sleep Apnea (OSA) Patients. Unknown status NCT01771406 Phase 4 Nebivolol
8 Somnodent vs Herbst in Mild and Moderate OSA Patients Unknown status NCT02724865 Phase 4
9 Donepezil Treatment for Sleep Apnea Patients Unknown status NCT00912457 Phase 4 donepezil;placebo
10 Effect of Nasal CPAP on Lipid Profile in Patients With Dyslipidaemia and Sleep Apnea Unknown status NCT02557412 Phase 4
11 Intermittent Hypoxia 2: Cardiovascular and Metabolism Unknown status NCT02058823 Phase 4 Placebo;Placebo;Valsartan;Amlodipine
12 Continuous Positive Airway Pressure in Sleep Apnea Syndrome: Effects on Metabolic Syndrome and Cardiac Damage Unknown status NCT00517777 Phase 4
13 Nasal Continuous Positive Airway Pressure (CPAP) in Chronic Fatigue and Sleep-disordered Breathing Unknown status NCT01368718 Phase 4
14 Multidisciplinary and Coordinated Follow-up Based on a Telemonitoring Web Platform for Improving CPAP Compliance in Low Cardiovascular Risk Sleep Apnea Patients : OPTISAS 1 Study Unknown status NCT01796769 Phase 4
15 Blood Pressure Reduction Induced by CPAP in Sleep Apnea Patients at High Cardiovascular Risk : OPTISAS 2 Study Unknown status NCT01505959 Phase 4
16 Effects of Botulinum Toxin Type A(Meditoxin®) on Sleep Bruxism Unknown status NCT01336439 Phase 4 Botulinum toxin type A (Meditoxin®)
17 Obstructive Sleep Apnea in the Absence of Metabolic Syndrome Completed NCT01635010 Phase 4
18 Sugammadex Compared With Neostigmin/Atropin for Neuromuscular Block Reversal in Patients With Obstructive Sleep Apnea Completed NCT02160223 Phase 4 Sugammadex;Neostigmine
19 Trial of Effects of Oral Xyrem and Zolpidem on Sleep-Disordered Breathing in Obstructive Sleep Apnea Patients Completed NCT00086281 Phase 4 Xyrem (X);Zolpidem (Z);Modafinil (M);Placebo (P)
20 Evaluation of Modafinil vs Placebo for Treatment of Anesthesia Delayed Emergence in Obstructive Sleep Apnea Completed NCT02494102 Phase 4 Modafinil;Placebo
21 Study to Determine the Effectiveness of Pillar Palatal Implants to Treat Obstructive Sleep Apnea Completed NCT00307957 Phase 4
22 Cardiovascular Impact of Obstructive Sleep Apnea Treatment in Normotensive Patients Completed NCT00741520 Phase 4
23 Nasal Budesonide in Children With Rhinitis and/or Mild Obstructive Sleep Apnea Syndrome Completed NCT00560586 Phase 4 Budesonide;placebo
24 Efficacy of Oral Leukotriene in Long Term Therapy of Mild and Moderate Obstructive Sleep Apnea Syndrome in Children Completed NCT00912171 Phase 4 budesonide (Aircort 50 nasal spray);montelukast (Singulair)
25 The Impact of Arousal Threshold in Obstructive Sleep Apnea Completed NCT02264353 Phase 4 Donepezil;placebo
26 Treatment of Patients With the Obstructive Sleep Apnea Syndrome at Altitude Completed NCT00714740 Phase 4 acetazolamide
27 Early Signs of Atherosclerosis in Obstructive Sleep Apnea: Effects of Treatment Completed NCT00400543 Phase 4
28 Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and Depression Completed NCT00518986 Phase 4 armodafinil;placebo
29 Mechanism of Action of Fluticasone Furoate in Childhood Obstructive Sleep Apnea Syndrome Completed NCT00603044 Phase 4 fluticasone furoate
30 Efficacy of CPAP Treatment on Blood Pressure of Resistant Hypertension Patients With Obstructive Sleep Apnea Syndrome Completed NCT01508754 Phase 4
31 Vasoactive Hormones During the Night in Patients With Obstructive Sleep Apnea Before and After Treatment With CPAP. Completed NCT00360659 Phase 4
32 Serotonin and the Upper Airway in Obstructive Sleep Apnea Completed NCT00100464 Phase 4 Paroxetine;5HTP
33 Sibutramine Versus Continuous Positive Airway Pressure (CPAP)in Obstructive Sleep Apnea (OSA) Patients Completed NCT00729963 Phase 4 Sibutramine
34 Efficacy and Safety of Adalimumab in Patients With Psoriasis and Obstructive Sleep Apnea Completed NCT01181570 Phase 4 Adalimumab;Placebo
35 Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea Completed NCT01344759 Phase 4 Dexmedetomidine;Propofol
36 Nasal Decongestion and Obstructive Sleep Apnea Completed NCT00630474 Phase 4 xylometazoline
37 Effects of Continuous Positive Airway Pressure and Valsartan Treatments on Arterial Blood Pressure in OSAS Patients Completed NCT00409487 Phase 4 Valsartant treatment
38 Effects of Obstructive Sleep Apnea Treatment by Fixed CPAP and by Auto-CPAP (Somnosmart2) Completed NCT00633711 Phase 4
39 Continuous Positive Airway Pressure and Acetazolamide to Treat Sleep Apnea Syndrome Patients at Altitude Completed NCT00928655 Phase 4 acetazolamide;placebo
40 Sleep Apnea-hypopnea Syndrome (SAHS) and Ventricular Arrhythmias Completed NCT00765713 Phase 4
41 The Endothelium Dysfunction in Patients of Obstructive Sleep Apnea Syndrome Completed NCT01699126 Phase 4 Statin
42 Renal Hemodynamics and Tubular Function in Patients With Obstructive Sleep Apnea and Healthy Controls Completed NCT00410085 Phase 4 L-NMMA (N-mono.methyl-L-arginine)
43 Inspire® Upper Airway Stimulation (UAS) System German Post-Market Study Completed NCT02293746 Phase 4
44 Reduction of Left Ventricular Hypertrophy After Eplerenone Therapy Completed NCT03186742 Phase 4 Eplerenone 50 mg Tab
45 Dexmedetomidine Added to Propofol for Drug Induced Sleep Endoscopy Completed NCT03091894 Phase 4 Propofol;Dexmedetomidine
46 Continuous Positive Airway Pressure (CPAP) Promotion And Prognosis - the Army Sleep Apnea Program (ASAP) Completed NCT00612157 Phase 4 Eszopiclone;Placebo control
47 CPAP in Diabetes Type 2 Patients With Sleep Apnea Completed NCT01801150 Phase 4
48 Oxidative Stress and Cardiovascular Morbidity in Sleep Apnea-Hypopnea Syndrome (SAHS) Completed NCT00487929 Phase 4
49 Sodium-Restricted Diet and Diuretic in the Treatment of Severe Sleep Apnea Completed NCT01945801 Phase 4 Lasilactone;Placebo
50 Auto Bilevel Adherence Following a Poor Initial Encounter With Continuous Positive Airway Pressure (CPAP) Completed NCT02522442 Phase 4

Search NIH Clinical Center for Apnea, Obstructive Sleep

Cochrane evidence based reviews: sleep apnea syndromes

Sources

Genetic Tests for Apnea, Obstructive Sleep

About this section

Genetic tests related to Apnea, Obstructive Sleep:

# Genetic test Affiliating Genes
1 Obstructive Sleep Apnea Syndrome 29
Sources

Anatomical Context for Apnea, Obstructive Sleep

About this section

MalaCards organs/tissues related to Apnea, Obstructive Sleep:

41
Heart, Endothelial, Testes, Liver, Tongue, Brain, Kidney
Sources

Publications for Apnea, Obstructive Sleep

About this section

Articles related to Apnea, Obstructive Sleep:

(show top 50) (show all 2124)
# Title Authors Year
1
Sleep Architecture in Patients With Primary Snoring and Obstructive Sleep Apnea. ( 29967674 )
2018
2
The Relation between Pregnancy-Associated Plasma Protein A and Obstructive Sleep Apnea Syndrome. ( 29973962 )
2018
3
Alterations of IGF-1, complement C3 and superoxide dismutase in patients with moderate-to-severe obstructive sleep apnea hypopnea syndrome. ( 29441807 )
2018
4
Decrease of Plasma Soluble (Pro)renin Receptor by Bariatric Surgery in Patients with Obstructive Sleep Apnea and Morbid Obesity. ( 29649379 )
2018
5
Prevalence, Risk Factors, Outcomes, and Treatment of Obstructive Sleep Apnea in Patients with Cerebrovascular Disease: A Systematic Review. ( 29555400 )
2018
6
Risk of gallstones in patients with obstructive sleep apnea: a nationwide observational cohort study. ( 29980983 )
2018
7
Association between obstructive sleep apnea and comorbidities with periodontal disease in adults. ( 29962700 )
2018
8
Forestier syndrome and obstructive sleep apnea: Surgical treatment. ( 29366867 )
2018
9
Incidence of Obstructive Sleep Apnea among Patients with Hidradenitis Suppurativa: a retrospective population-based cohort analysis. ( 29957857 )
2018
10
A Modified Definition for Obstructive Sleep Apnea in Home Sleep Apnea Testing after Stroke or Transient Ischemic Attack. ( 29428326 )
2018
11
Lithuanian dentists' knowledge, attitudes, and clinical practices regarding obstructive sleep apnea: A nationwide cross-sectional study. ( 29431599 )
2018
12
Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea. ( 29433520 )
2018
13
Application of 3C insulin pump system in combination with non-invasive ventilation in the treatment of a patient with type 2 diabetes and obstructive sleep apnea syndrome. ( 28429854 )
2018
14
Red cell distribution width and uric acid in patients with obstructive sleep apnea. ( 28296212 )
2018
15
The effect of positive and negative message framing on short term continuous positive airway pressure compliance in patients with obstructive sleep apnea. ( 29445540 )
2018
16
Association between obstructive sleep apnea and alcohol, caffeine and tobacco: a meta-analysis. ( 29971810 )
2018
17
Correlations between pediatric obstructive sleep apnea and longitudinal growth. ( 29447889 )
2018
18
Cycle length identifies obstructive sleep apnea and central sleep apnea in heart failure with reduced ejection fraction. ( 29637409 )
2018
19
Pericardial Effusion in Obstructive Sleep Apnea without Pulmonary Arterial Hypertension and Daily Hypoxemia - is it Unusual? ( 29808980 )
2018
20
MiR-664a-3p expression in patients with obstructive sleep apnea: A potential marker of atherosclerosis. ( 29419680 )
2018
21
IGF-1-based screening reveals a low prevalence of acromegaly in patients with obstructive sleep apnea. ( 29388045 )
2018
22
Pre- and post-operative evaluation of the frequency of nocturnal enuresis and Modified Pediatric Epworth Scale in pediatric obstructive sleep apnea patients. ( 29447815 )
2018
23
Severe Obstructive Sleep Apnea is Associated with Alterations in the Nasal Microbiome and Increase in Inflammation. ( 29969291 )
2018
24
Correction to: Obstructive sleep apnea does not impair cardiorespiratory responses to progressive exercise performed until exhaustion in hypertensive elderly. ( 29442289 )
2018
25
Improvement of Neuropathy Symptoms With Treatment of Obstructive Sleep Apnea in a Patient With Charcot-Marie-Tooth Disease. ( 29246265 )
2018
26
Kinesthetic stimulation for obstructive sleep apnea syndrome: An "on-off" proof of concept trial. ( 29449609 )
2018
27
Hepcidin, soluble transferrin receptor and IL-6 levels in obese children and adolescents with and without type 2 diabetes mellitus/impaired glucose tolerance and their association with obstructive sleep apnea. ( 29305826 )
2018
28
Gender differences in clinical and polysomnographic features of obstructive sleep apnea: a clinical study of 2827 patients. ( 28197893 )
2018
29
Opioids for Acute Pain Management in Patients With Obstructive Sleep Apnea: A Systematic Review. ( 29958218 )
2018
30
Oximetry use in obstructive sleep apnea. ( 29972344 )
2018
31
Effect of continuous positive airway pressure on liver enzymes in obstructive sleep apnea: A meta-analysis. ( 27614004 )
2018
32
Obstructive Sleep Apnea in a rural population in South India: Feasibility of health care workers to administer level III sleep study. ( 29970768 )
2018
33
Adenotonsillectomy in children with sickle cell disease and obstructive sleep apnea. ( 29958601 )
2018
34
Comorbid obstructive sleep apnea and increased risk for sickle cell disease morbidity. ( 29450676 )
2018
35
Cerebral blood flow, oxygen metabolism and lactate during hypoxia in patients with obstructive sleep apnea. ( 29309697 )
2018
36
Clinical application of MRI-respiratory gating technology in the evaluation of children with obstructive sleep apnea hypopnea syndrome. ( 29369187 )
2018
37
Can STOP-Bang and Pulse Oximetry Detect and Exclude Obstructive Sleep Apnea? ( 29958223 )
2018
38
Study of the upper airway of obstructive sleep apnea patient using fluid structure interaction. ( 29317326 )
2018
39
The paradigm of obstructive sleep apnea in aging: interactions with telomere length. ( 29957485 )
2018
40
Integrating loop gain into the understanding of obstructive sleep apnea mechanisms. ( 29968907 )
2018
41
Association of Adenotonsillectomy With Blood Pressure Among Hypertensive and Nonhypertensive Children With Obstructive Sleep Apnea. ( 29450504 )
2018
42
Association between continuous positive airway pressure and serum aminotransferases in patients with obstructive sleep apnea. ( 29224042 )
2018
43
Gamma-glutamyl transferase activity as a predictive marker for severity of obstructive sleep apnea syndrome and concomitant hypertension. ( 29330970 )
2018
44
The prevention of delirium in elderly with obstructive sleep apnea (PODESA) study: protocol for a multi-centre prospective randomized, controlled trial. ( 29298664 )
2018
45
A Couples-Oriented Intervention for Positive Airway Pressure Therapy Adherence: A Pilot Study of Obstructive Sleep Apnea Patients and Their Partners. ( 29388827 )
2018
46
Obstructive Sleep Apnea in a Severely Obese Child With Combined Central Sleep Apnea and Sleep-Related Hypoventilation Disorder Caused by a Medullary Tumor. ( 29852906 )
2018
47
Importance of laboratory parameters in patients with obstructive sleep apnea and their relationship with cardiovascular diseases. ( 28345811 )
2018
48
Risk of obstructive sleep apnea in open-angle glaucoma versus controls using the STOP-Bang questionnaire. ( 29426446 )
2018
49
The correlation between obstructive sleep apnea and diabetic neuropathy: A meta-analysis. ( 29728306 )
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Proteomic biomarkers of cognitive impairment in obstructive sleep apnea syndrome. ( 29968150 )
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Sources

Variations for Apnea, Obstructive Sleep

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Expression for Apnea, Obstructive Sleep

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Search GEO for disease gene expression data for Apnea, Obstructive Sleep.
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Pathways for Apnea, Obstructive Sleep

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Pathways related to Apnea, Obstructive Sleep according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways 65
Show member pathways
 12.65 ADIPOQ IL6 INS LEP TNF
2
Folate Metabolism 1
Show member pathways
 12 CRP IL6 INS TNF
3
Insulin resistance 37
Show member pathways
 11.74 IL6 INS TNF
4
TNF signaling pathway 37
11.72 EDN1 IL6 TNF
5
HIF-1 signaling pathway 37
11.67 EDN1 IL6 INS
6
AGE-RAGE signaling pathway in diabetic complications 37
11.63 EDN1 IL6 TNF
7
Type II diabetes mellitus 37 1
Show member pathways
 11.59 ADIPOQ INS TNF
8
Adipogenesis 1
11.47 ADIPOQ IL6 INS LEP TNF
9
Adipocytokine signaling pathway 37
11.42 ADIPOQ LEP TNF
10
Lung fibrosis 1
11.3 EDN1 IL6 TNF
11
Development_Leptin signaling via JAK/STAT and MAPK cascades 22
Show member pathways
 10.91 CRP EDN1 LEP
12
Overview of nanoparticle effects 1
10.61 CRP IL6 TNF
13
Transcription factor regulation in adipogenesis 1
10.27 ADIPOQ IL6 LEP TNF
Sources

GO Terms for Apnea, Obstructive Sleep

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Cellular components related to Apnea, Obstructive Sleep according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 ADIPOQ CRP EDN1 IL6 INS LEP
2 extracellular region GO:0005576 9.28 ADIPOQ CRP EDN1 HCRT IL6 INS

Biological processes related to Apnea, Obstructive Sleep according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.99 EDN1 HTR2A IL6 INS LEP
2 response to drug GO:0042493 9.93 ADIPOQ EDN1 HTR2A REN
3 positive regulation of DNA binding transcription factor activity GO:0051091 9.83 EDN1 IL6 TNF
4 glucose homeostasis GO:0042593 9.8 ADIPOQ INS LEP
5 response to organic substance GO:0010033 9.8 INS REN TNF
6 defense response to Gram-positive bacterium GO:0050830 9.79 CRP IL6 TNF
7 regulation of blood pressure GO:0008217 9.71 EDN1 LEP REN
8 cellular response to drug GO:0035690 9.7 ADIPOQ EDN1 REN
9 response to glucocorticoid GO:0051384 9.69 ADIPOQ IL6 TNF
10 positive regulation of MAP kinase activity GO:0043406 9.67 EDN1 HTR2A TNF
11 negative regulation of lipid catabolic process GO:0050995 9.65 INS TNF
12 leukocyte tethering or rolling GO:0050901 9.65 LEP TNF
13 regulation of protein secretion GO:0050708 9.65 INS TNF
14 response to nutrient levels GO:0031667 9.65 ADIPOQ INS LEP
15 positive regulation of cellular protein metabolic process GO:0032270 9.64 ADIPOQ INS
16 positive regulation of insulin receptor signaling pathway GO:0046628 9.64 INS LEP
17 positive regulation of protein kinase activity GO:0045860 9.63 ADIPOQ MMD TNF
18 negative regulation of gluconeogenesis GO:0045721 9.61 ADIPOQ INS
19 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.61 ADIPOQ CRP
20 positive regulation of smooth muscle cell proliferation GO:0048661 9.61 EDN1 IL6 TNF
21 negative regulation of glucose import GO:0046325 9.6 LEP TNF
22 regulation of behavior GO:0050795 9.58 AHI1 HTR2A
23 artery smooth muscle contraction GO:0014824 9.58 EDN1 HTR2A
24 negative regulation of fat cell differentiation GO:0045599 9.58 ADIPOQ IL6 TNF
25 negative regulation of potassium ion transport GO:0043267 9.57 HCRT HTR2A
26 negative regulation of blood vessel diameter GO:0097756 9.56 CRP INS
27 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.56 ADIPOQ HTR2A IL6 INS
28 negative regulation of hormone secretion GO:0046888 9.55 ADIPOQ EDN1
29 response to activity GO:0014823 9.54 ADIPOQ EDN1 LEP
30 acute-phase response GO:0006953 9.5 CRP IL6 INS
31 regulation of signaling receptor activity GO:0010469 9.5 ADIPOQ EDN1 HCRT IL6 INS LEP
32 glucose metabolic process GO:0006006 9.46 ADIPOQ INS LEP TNF
33 negative regulation of lipid storage GO:0010888 8.92 CRP IL6 LEP TNF

Molecular functions related to Apnea, Obstructive Sleep according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 ADIPOQ AHI1 CENPJ CRP INS PPCDC
2 cytokine activity GO:0005125 9.46 ADIPOQ EDN1 IL6 TNF
3 insulin-like growth factor receptor binding GO:0005159 9.26 INS REN
4 hormone activity GO:0005179 8.92 ADIPOQ EDN1 INS LEP
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Sources for Apnea, Obstructive Sleep

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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