OSA
MCID: APN008
MIFTS: 68

Apnea, Obstructive Sleep (OSA)

Categories: Mental diseases, Respiratory diseases

Aliases & Classifications for Apnea, Obstructive Sleep

MalaCards integrated aliases for Apnea, Obstructive Sleep:

Name: Apnea, Obstructive Sleep 57
Obstructive Sleep Apnea Syndrome 57 12 25 29 15
Obstructive Sleep Apnea 12 76 25 15 63
Sleep Apnea, Obstructive 25 44 73
Upper Airway Resistance Sleep Apnea Syndrome 25 73
Sleep Apnea/hypopnea Syndrome 57 25
Osas 57 25
Sahs 57 25
Osa 57 25
Sleep Apnea/hypopnea Syndrome; Sahs; Osahs 57
Obstructive Sleep Apnea Syndrome; Osas 57
Sleep Apnea Syndrome, Obstructive 25
Sleep Apnea Hypopnea Syndrome 25
Sleep Apnea Obstructive 55
Sleep Apnea Syndromes 73
Apnea, Obstructive 25
Obstructive Apnea 25
Osahs 25

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
apnea, obstructive sleep:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 107650
Disease Ontology 12 DOID:0050848
ICD10 33 G47.33
ICD9CM 35 327.23
MeSH 44 D020181
SNOMED-CT 68 78275009
MedGen 42 C0520679

Summaries for Apnea, Obstructive Sleep

PubMed Health : 63 About obstructive sleep apnea: We all know what it is like to feel tired after a sleepless night because of things like noise, worries or stress. But what if you do actually get enough sleep and still feel absolutely beat the next morning? This is normal for many people with obstructive sleep apnea (OSA): They do not get enough air while they are sleeping (but do not usually notice this), have breathing pauses, and feel very sleepy during the day. In the long term, this increases their risk of developing other illnesses and can have a huge effect on their quality of life.

MalaCards based summary : Apnea, Obstructive Sleep, also known as obstructive sleep apnea syndrome, is related to kawasaki disease and lipid metabolism disorder, and has symptoms including seizures, tremor and dyspnea. An important gene associated with Apnea, Obstructive Sleep is LEP (Leptin), and among its related pathways/superpathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Selenium Micronutrient Network. The drugs Guanfacine and Hydrochlorothiazide have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and endothelial, and related phenotypes are obstructive sleep apnea and anosmia

Disease Ontology : 12 A sleep apnea that is characterized by repeated collapse and obstruction of the upper airway during sleep, which results in reduced airflow (hypopnea) or complete airflow cessation (apnea), oxygen desaturation, and arousals from sleep.

Genetics Home Reference : 25 Obstructive sleep apnea is a condition in which individuals experience pauses in breathing (apnea) during sleep, which are associated with partial or complete closure of the throat (upper airway). Complete closure can lead to apnea while partial closure allows breathing but decrease the intake of oxygen (hypopnea).

OMIM : 57 Obstructive sleep apnea is a common, chronic, complex disease associated with serious cardiovascular and neuropsychologic sequelae and with substantial social and economic costs (Palmer et al., 2003). (107650)

Wikipedia : 76 Obstructive sleep apnea (OSA) is the most common type of sleep apnea and is caused by complete or... more...

Related Diseases for Apnea, Obstructive Sleep

Diseases related to Apnea, Obstructive Sleep via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 509)
# Related Disease Score Top Affiliating Genes
1 kawasaki disease 31.9 CRP IL6 TNF
2 lipid metabolism disorder 30.6 LEP INS CRP ADIPOQ
3 gestational diabetes 30.6 ADIPOQ INS LEP
4 sleep apnea 30.4 TNF REN LEP INS IL6 HTR2A
5 aortic disease 30.4 CRP IL6 REN
6 critical limb ischemia 30.3 IL6 TNF
7 mixed sleep apnea 30.3 AHI1 MMD
8 obesity-hypoventilation syndrome 30.3 LEP IL6 ADIPOQ
9 fatty liver disease 30.2 TNF LEP INS IL6 ADIPOQ
10 glucose intolerance 30.2 LEP INS CRP ADIPOQ
11 periodontal disease 30.2 CRP IL6 TNF
12 interstitial lung disease 30.2 EDN1 IL6 TNF
13 arteriosclerosis 30.2 INS IL6 EDN1 CRP ADIPOQ
14 coronary heart disease 1 30.1 INS IL6 EDN1 CRP ADIPOQ
15 liver disease 30.1 TNF LEP INS IL6 ADIPOQ
16 chronic fatigue syndrome 30.1 HTR2A IL6 TNF
17 prader-willi syndrome 30.1 ADIPOQ HCRT INS LEP
18 diabetes mellitus, noninsulin-dependent 30.1 TNF LEP INS IL6 EDN1 CRP
19 systolic heart failure 30.1 IL6 EDN1 CRP
20 nonalcoholic steatohepatitis 30.0 TNF LEP INS ADIPOQ
21 chronic thromboembolic pulmonary hypertension 30.0 CRP EDN1
22 pericardial effusion 30.0 REN IL6 CRP
23 cystitis 30.0 CRP IL6 TNF
24 purpura 30.0 CRP IL6 TNF
25 juvenile rheumatoid arthritis 30.0 CRP IL6 TNF
26 idiopathic edema 30.0 INS EDN1 ADIPOQ
27 periodontitis 30.0 CRP IL6 TNF
28 angina pectoris 30.0 IL6 EDN1 CRP
29 nonalcoholic fatty liver disease 30.0 TNF LEP INS IL6 CRP ADIPOQ
30 complex regional pain syndrome 29.9 TNF IL6 EDN1
31 peripheral nervous system disease 29.9 IL6 INS TNF
32 ischemic heart disease 29.9 TNF IL6 CRP
33 eclampsia 29.9 EDN1 REN TNF
34 periodic limb movement disorder 29.9 HTR2A FXYD1 CTNNBL1
35 pulmonary edema 29.9 TNF REN EDN1 CRP
36 diabetes mellitus 29.9 TNF REN LEP INS IL6 EDN1
37 respiratory failure 29.9 CRP SLC4A1 TNF
38 kidney disease 29.8 REN INS IL6 EDN1 CRP ADIPOQ
39 vascular disease 29.8 TNF REN INS IL6 EDN1 CRP
40 morbid obesity 29.8 LEP INS HCRT CRP ADIPOQ
41 pre-eclampsia 29.7 IL6 EDN1 ADIPOQ TNF REN LEP
42 chronic kidney failure 29.7 REN LEP INS IL6 EDN1 CRP
43 cerebrovascular disease 29.7 TNF REN INS IL6 CRP ADIPOQ
44 atherosclerosis susceptibility 29.7 TNF INS IL6 CRP ADIPOQ
45 body mass index quantitative trait locus 11 29.4 TNF LEP INS IL6 HCRT CRP
46 hypertension, essential 29.4 REN LEP INS EDN1 CRP ADIPOQ
47 myocardial infarction 29.4 TNF REN INS IL6 EDN1 CRP
48 dilated cardiomyopathy 29.4 CRP EDN1 IL6 REN TNF
49 heart disease 29.3 TNF REN INS IL6 EDN1 CRP
50 arteries, anomalies of 29.1 TNF REN LEP INS IL6 EDN1

Graphical network of the top 20 diseases related to Apnea, Obstructive Sleep:



Diseases related to Apnea, Obstructive Sleep

Symptoms & Phenotypes for Apnea, Obstructive Sleep

Symptoms via clinical synopsis from OMIM:

57
Resp:
obstructive sleep apnea
snoring

Misc:
hypersomnolence
restless movements during sleep

Neuro:
anosmia
partial complex seizures


Clinical features from OMIM:

107650

Human phenotypes related to Apnea, Obstructive Sleep:

32
# Description HPO Frequency HPO Source Accession
1 obstructive sleep apnea 32 HP:0002870
2 anosmia 32 HP:0000458
3 excessive daytime somnolence 32 HP:0001262
4 snoring 32 HP:0025267
5 focal impaired awareness seizure 32 HP:0002384

UMLS symptoms related to Apnea, Obstructive Sleep:


seizures, tremor, dyspnea, back pain, apnea, pain, headache, syncope, excessive daytime somnolence, chronic pain, sciatica, wheezing, sleep disturbances, snoring, coughing, cheyne-stokes respiration, vertigo/dizziness, sleeplessness, labored breathing, insomnia with sleep apnea, unspecified, hypersomnia with sleep apnea, unspecified, disruption of 24 hour sleep wake cycle, unspecified

MGI Mouse Phenotypes related to Apnea, Obstructive Sleep:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.23 ADIPOQ CENPJ CRP EDN1 FXYD1 HCRT
2 behavior/neurological MP:0005386 10.18 ADIPOQ AHI1 CENPJ HCRT HTR2A IL6
3 homeostasis/metabolism MP:0005376 10.15 ADIPOQ AHI1 CENPJ CRP EDN1 HCRT
4 growth/size/body region MP:0005378 10.14 ADIPOQ AHI1 CENPJ EDN1 HCRT IL6
5 immune system MP:0005387 10.06 ADIPOQ AHI1 CENPJ CRP CTNNBL1 IL6
6 endocrine/exocrine gland MP:0005379 10.03 ADIPOQ CENPJ EDN1 HTR2A IL6 INS
7 muscle MP:0005369 10.03 ADIPOQ CENPJ EDN1 FXYD1 HCRT HTR2A
8 adipose tissue MP:0005375 9.97 ADIPOQ CENPJ IL6 INS LEP TNF
9 nervous system MP:0003631 9.85 ADIPOQ AHI1 CENPJ EDN1 HCRT IL6
10 renal/urinary system MP:0005367 9.56 ADIPOQ AHI1 EDN1 IL6 INS LEP
11 skeleton MP:0005390 9.23 ADIPOQ CENPJ EDN1 HTR2A IL6 INS

Drugs & Therapeutics for Apnea, Obstructive Sleep

PubMedHealth treatment related to Apnea, Obstructive Sleep: 63

If you are very overweight, losing weight can help improve sleep apnea. There are also many treatment options that aim to relieve sleep apnea. These include machines that support breathing during the night, surgery, and special aids such as mouth guards. Some of these treatments have been scientifically proven to help people with sleep apnea. Medication is currently not used for the treatment of sleep apnea. There is no scientific evidence that the available medications work.The most effective treatment for severe sleep apnea is called CPAP therapy. CPAP stands for “continuous positive airway pressure.” In this treatment approach, air is taken from the immediate surroundings and blown into your airways at night using low pressure. While you sleep, you wear a breathing mask that is connected to a machine called a respirator. The pressure keeps the upper airways open. People who use this machine have fewer breathing pauses, or even none at all. This can noticeably improve the symptoms such as tiredness during the day. Common side effects include a dry throat and an irritated, sometimes blocked nose.

Drugs for Apnea, Obstructive Sleep (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 437)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
2
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
3
Nebivolol Approved, Investigational Phase 4 99200-09-6, 152520-56-4, 118457-14-0 71301
4 tannic acid Approved Phase 4,Phase 3,Phase 2,Not Applicable
5
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 94-09-7, 1994-09-7 2337
6
Donepezil Approved Phase 4 120014-06-4 3152
7
Acetylcholine Approved Phase 4 51-84-3 187
8
Morphine Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 57-27-2 5288826
9
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 113775-47-6 68602 5311068
10
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 2078-54-8 4943
11
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 437-38-7 3345
12
Acetaminophen Approved Phase 4,Phase 3,Not Applicable 103-90-2 1983
13
Amlodipine Approved Phase 4,Phase 2,Phase 3 88150-42-9 2162
14
Nitric Oxide Approved Phase 4 10102-43-9 145068
15
Ibuprofen Approved Phase 4,Phase 3,Not Applicable 15687-27-1 3672
16
Norepinephrine Approved Phase 4,Not Applicable 51-41-2 439260
17
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 6740-88-1 3821
18
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
19
Atropine Approved, Vet_approved Phase 4 51-55-8, 5908-99-6 174174
20
Montelukast Approved Phase 4,Phase 3,Phase 2 158966-92-8 5281040
21
Zolpidem Approved Phase 4 82626-48-0 5732
22
Sodium oxybate Approved Phase 4 502-85-2 5360545
23
Armodafinil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 112111-43-0
24
Modafinil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 68693-11-8 4236
25
Budesonide Approved Phase 4,Phase 3,Phase 1 51333-22-3 63006 5281004
26
Acetazolamide Approved, Vet_approved Phase 4,Phase 2,Not Applicable 59-66-5 1986
27
Carbidopa Approved Phase 4 28860-95-9 34359 38101
28
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
29
Levodopa Approved Phase 4 59-92-7 6047
30
mometasone furoate Approved, Vet_approved Phase 4,Phase 3,Not Applicable 83919-23-7
31
Fluticasone Approved, Experimental Phase 4,Phase 3,Not Applicable 90566-53-3 62924
32
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
33
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 1177-87-3
34
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 50-02-2 5743
35
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Not Applicable 28523-86-6 5206
36
Ondansetron Approved Phase 4,Phase 3 99614-02-5 4595
37
Nitrous oxide Approved, Vet_approved Phase 4,Not Applicable 10024-97-2 948
38
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
39
Adalimumab Approved Phase 4 331731-18-1 16219006
40
Mannitol Approved, Investigational Phase 4,Phase 3 69-65-8 453 6251
41
Xylometazoline Approved, Investigational Phase 4,Not Applicable 526-36-3 5709
42
Ephedrine Approved Phase 4,Not Applicable 299-42-3 9294
43
Pseudoephedrine Approved Phase 4,Not Applicable 90-82-4 7028
44
Angiotensin II Approved, Investigational Phase 4,Phase 2,Not Applicable 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
45
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
46
Desflurane Approved Phase 4 57041-67-5 42113
47
Remifentanil Approved Phase 4,Early Phase 1 132875-61-7 60815
48
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
49
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
50
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613

Interventional clinical trials:

(show top 50) (show all 1485)
# Name Status NCT ID Phase Drugs
1 Cost-utility Study of Continuous Positive Airway Pressure Treatment in Obstructive Sleep Apnea Syndrome Patients Unknown status NCT01590420 Phase 4
2 Validation of Functional Imaging as Predictive Tool for Outcome of Mandibular Replacement Appliance Therapy in Obstructive Sleep Apnea Hypopnea Syndrome Patients Unknown status NCT01524510 Phase 4
3 PROMAD: Predicting Therapeutic Outcome of Mandibular Advancement Device Treatment in Obstructive Sleep Apnea Unknown status NCT01532050 Phase 4
4 Impact of Obstructive Sleep Apnea Treatment in Patients With Metabolic Syndrome Unknown status NCT02295202 Phase 4
5 A Randomized Cross Over Trial of Two Treatments for Obstructive Sleep Apnea in Veterans With Post Traumatic Stress Disorder Unknown status NCT01535586 Phase 4
6 Treatment of OSA Associated Hypertension With Alpha 2 Agonist or Diuretic Unknown status NCT02699125 Phase 4 Guanfacine;Hydrochlorothiazide
7 Cardiovascular Impact, Quality e Quantity of Sleep in Bed Partners of Patients With Obstructive Sleep Apnea Unknown status NCT03011294 Phase 4
8 Comparison of the Pentax AWS® With the Macintosh Laryngoscopic Intubation in Obstructive Sleep Apnea Syndrome Patients Unknown status NCT01428570 Phase 4
9 CPAP and Nebivolol in Hypertensive Obstructive Sleep Apnea (OSA) Patients. Unknown status NCT01771406 Phase 4 Nebivolol
10 Auto-PAP for Pulmonary Hypertension Treatment in Decompensated HF Patients With Sleep Apnea. Unknown status NCT02963597 Phase 4
11 Somnodent vs Herbst in Mild and Moderate OSA Patients Unknown status NCT02724865 Phase 4
12 Donepezil Treatment for Sleep Apnea Patients Unknown status NCT00912457 Phase 4 donepezil;placebo
13 Continuous Positive Airway Pressure in Sleep Apnea Syndrome: Effects on Metabolic Syndrome and Cardiac Damage Unknown status NCT00517777 Phase 4
14 Nasal Continuous Positive Airway Pressure (CPAP) in Chronic Fatigue and Sleep-disordered Breathing Unknown status NCT01368718 Phase 4
15 Multidisciplinary and Coordinated Follow-up Based on a Telemonitoring Web Platform for Improving CPAP Compliance in Low Cardiovascular Risk Sleep Apnea Patients : OPTISAS 1 Study Unknown status NCT01796769 Phase 4
16 Blood Pressure Reduction Induced by CPAP in Sleep Apnea Patients at High Cardiovascular Risk : OPTISAS 2 Study Unknown status NCT01505959 Phase 4
17 Effects of Botulinum Toxin Type A(Meditoxin®) on Sleep Bruxism Unknown status NCT01336439 Phase 4 Botulinum toxin type A (Meditoxin®)
18 Obstructive Sleep Apnea in the Absence of Metabolic Syndrome Completed NCT01635010 Phase 4
19 The Impact of Venlafaxine on Apnea Hypopnea Index in Obstructive Sleep Apnea Active, not recruiting NCT02714400 Phase 4 Venlafaxine;Placebo
20 FAST as a Treatment for Obstructive Sleep Apnea Terminated NCT01611779 Phase 4
21 Ketamine Infusion for Pediatric Patients With Obstructive Sleep Apnea Syndrome (OSAS) After Tonsillectomy Completed NCT02425202 Phase 4 Ketamine
22 Sugammadex Compared With Neostigmin/Atropin for Neuromuscular Block Reversal in Patients With Obstructive Sleep Apnea Completed NCT02160223 Phase 4 Sugammadex;Neostigmine
23 Effect of Montelukast Therapy in Obstructive Sleep Apnea(OSA) Children Terminated NCT01027806 Phase 4 Montelukast
24 Trial of Effects of Oral Xyrem and Zolpidem on Sleep-Disordered Breathing in Obstructive Sleep Apnea Patients Completed NCT00086281 Phase 4 Xyrem (X);Zolpidem (Z);Modafinil (M);Placebo (P)
25 Evaluation of Modafinil vs Placebo for Treatment of Anesthesia Delayed Emergence in Obstructive Sleep Apnea Completed NCT02494102 Phase 4 Modafinil;Placebo
26 Study to Determine the Effectiveness of Pillar Palatal Implants to Treat Obstructive Sleep Apnea Completed NCT00307957 Phase 4
27 Cardiovascular Impact of Obstructive Sleep Apnea Treatment in Normotensive Patients Completed NCT00741520 Phase 4
28 Nasal Budesonide in Children With Rhinitis and/or Mild Obstructive Sleep Apnea Syndrome Completed NCT00560586 Phase 4 Budesonide;placebo
29 Decreasing Post-operative Complications of Obstructive Sleep Apnea by Introducing an Intensified Monitoring and Care Protocol Recruiting NCT03281408 Phase 4 Intra-operative: Sedation Techniques
30 Burden of Obstructive Sleep Apnea in Stroke (BOSAST) Terminated NCT00952211 Phase 4
31 Efficacy of Oral Leukotriene in Long Term Therapy of Mild and Moderate Obstructive Sleep Apnea Syndrome in Children Completed NCT00912171 Phase 4 budesonide (Aircort 50 nasal spray);montelukast (Singulair)
32 The Impact of Arousal Threshold in Obstructive Sleep Apnea Completed NCT02264353 Phase 4 Donepezil;placebo
33 Treatment of Patients With the Obstructive Sleep Apnea Syndrome at Altitude Completed NCT00714740 Phase 4 acetazolamide
34 Effect of Long-acting Levodopa on Obstructive Sleep Apnea in Parkinson's Disease Recruiting NCT03111485 Phase 4 Sinemet CR;Placebo oral capsule
35 Early Signs of Atherosclerosis in Obstructive Sleep Apnea: Effects of Treatment Completed NCT00400543 Phase 4
36 Intranasal Steroids for the Treatment of Nocturnal Enuresis With Associated Obstructive Sleep Apnea Withdrawn NCT01861145 Phase 4 Nasonex
37 Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and Depression Completed NCT00518986 Phase 4 armodafinil;placebo
38 Mechanism of Action of Fluticasone Furoate in Childhood Obstructive Sleep Apnea Syndrome Completed NCT00603044 Phase 4 fluticasone furoate
39 Efficacy of CPAP Treatment on Blood Pressure of Resistant Hypertension Patients With Obstructive Sleep Apnea Syndrome Completed NCT01508754 Phase 4
40 Palatal Implants in Combination With Continuous Positive Airway Pressure to Treat Obstructive Sleep Apnea Terminated NCT00730041 Phase 4
41 Vasoactive Hormones During the Night in Patients With Obstructive Sleep Apnea Before and After Treatment With CPAP. Completed NCT00360659 Phase 4
42 Effect of Ketorolac on Post Adenotonsillectomy Pain Recruiting NCT03467750 Phase 4 Ketorolac;Standard of Care
43 Serotonin and the Upper Airway in Obstructive Sleep Apnea Completed NCT00100464 Phase 4 Paroxetine;5HTP
44 Sibutramine Versus Continuous Positive Airway Pressure (CPAP)in Obstructive Sleep Apnea (OSA) Patients Completed NCT00729963 Phase 4 Sibutramine
45 Outcome of IV Acetaminophen Use in Laparoscopic Cholecystectomies in Patients at Risk of OSA Withdrawn NCT02056678 Phase 4 acetaminophen, IV preparation
46 Efficacy and Safety of Adalimumab in Patients With Psoriasis and Obstructive Sleep Apnea Completed NCT01181570 Phase 4 Adalimumab;Placebo
47 Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea Completed NCT01344759 Phase 4 Dexmedetomidine;Propofol
48 Nasal Decongestion and Obstructive Sleep Apnea Completed NCT00630474 Phase 4 xylometazoline
49 Effects of Continuous Positive Airway Pressure (CPAP) in Heart Remodeling by Magnetic Resonance Imaging (MRI) Terminated NCT00727454 Phase 4
50 Effects of Continuous Positive Airway Pressure and Valsartan Treatments on Arterial Blood Pressure in OSAS Patients Completed NCT00409487 Phase 4 Valsartant treatment

Search NIH Clinical Center for Apnea, Obstructive Sleep

Cochrane evidence based reviews: sleep apnea, obstructive

Genetic Tests for Apnea, Obstructive Sleep

Genetic tests related to Apnea, Obstructive Sleep:

# Genetic test Affiliating Genes
1 Obstructive Sleep Apnea Syndrome 29

Anatomical Context for Apnea, Obstructive Sleep

MalaCards organs/tissues related to Apnea, Obstructive Sleep:

41
Heart, Testes, Endothelial, Tongue, Brain, Liver, Lung

Publications for Apnea, Obstructive Sleep

Articles related to Apnea, Obstructive Sleep:

(show top 50) (show all 1211)
# Title Authors Year
1
Obstructive sleep apnea syndrome and olfactory perception: An OERP study. ( 30006255 )
2019
2
The Relation between Pregnancy-Associated Plasma Protein A and Obstructive Sleep Apnea Syndrome. ( 29973962 )
2018
3
Application of 3C insulin pump system in combination with non-invasive ventilation in the treatment of a patient with type 2 diabetes and obstructive sleep apnea syndrome. ( 28429854 )
2018
4
Kinesthetic stimulation for obstructive sleep apnea syndrome: An "on-off" proof of concept trial. ( 29449609 )
2018
5
Gamma-glutamyl transferase activity as a predictive marker for severity of obstructive sleep apnea syndrome and concomitant hypertension. ( 29330970 )
2018
6
Proteomic biomarkers of cognitive impairment in obstructive sleep apnea syndrome. ( 29968150 )
2018
7
The Effects of Sleeping With or Without Prostheses on Sleep Quality, Sleep Bruxism, and Signs of Obstructive Sleep Apnea Syndrome: A Pilot Study. ( 29723310 )
2018
8
Superficial punctate keratopathy in a pediatric patient was related to adenoid hypertrophy and obstructive sleep apnea syndrome: a case report. ( 29471795 )
2018
9
The aging effect on upper airways collapse of patients with obstructive sleep apnea syndrome. ( 30317385 )
2018
10
Hypertension and Atrial Fibrillation: What is the prevalence of obstructive sleep apnea syndrome? ( 30325486 )
2018
11
Non-alcoholic fatty liver disease is an independent risk factor for inflammation in obstructive sleep apnea syndrome in obese Asian Indians. ( 30032465 )
2018
12
Total improvement after surgery for obstructive sleep apnea syndrome in a patient with concurrent malignant idiopathic intracranial hypertension. ( 30117763 )
2018
13
Prognosis of Obesity Hypoventilation Syndrome With and Without Concomitant Obstructive Sleep Apnea Syndrome. ( 29103673 )
2018
14
Comparison between auto-trilevel and bilevel positive airway pressure ventilation for treatment of patients with concurrent obesity hypoventilation syndrome and obstructive sleep apnea syndrome. ( 30426457 )
2018
15
Is Autonomic Activation a Middleman Between Obstructive Sleep Apnea Syndrome and Psoriasis? ( 29852921 )
2018
16
Efficacy of exercise as a treatment for Obstructive Sleep Apnea Syndrome: A systematic review. ( 30477841 )
2018
17
Body surface area: a new anthropometric measurement for obstructive sleep apnea syndrome. ( 30479226 )
2018
18
Heated humidification did not improve compliance of positive airway pressure and subjective daytime sleepiness in obstructive sleep apnea syndrome: A meta-analysis. ( 30517168 )
2018
19
Assessment of right atrium dysfunction in patients with obstructive sleep apnea syndrome using velocity vector imaging. ( 30545377 )
2018
20
Is obstructive sleep apnea syndrome related to nocturia? ( 30548821 )
2018
21
Computational fluid dynamics analysis of H-uvulopalatopharyngoplasty in obstructive sleep apnea syndrome. ( 30553601 )
2018
22
The Role of Modified Expansion Sphincter Pharyngoplasty in Multilevel Obstructive Sleep Apnea Syndrome Surgery. ( 30357048 )
2018
23
Prevalence of newly established thyroid disorders in patients with moderate-to-severe obstructive sleep apnea syndrome. ( 30368659 )
2018
24
Is NREM-predominant obstructive sleep apnea syndrome a different clinical entity? ( 30384562 )
2018
25
Association Between 25-Hydroxyvitamin D and Bone Mineral Density in People With Obstructive Sleep Apnea Syndrome. ( 30396726 )
2018
26
Oropharyngeal Muscle Exercise Therapy Improves Signs and Symptoms of Post-stroke Moderate Obstructive Sleep Apnea Syndrome. ( 30420832 )
2018
27
Obstructive sleep apnea syndrome in children. ( 30444706 )
2018
28
Effect of Therapy on Choroidal Thickness in Patients With Obstructive Sleep Apnea Syndrome. ( 30457643 )
2018
29
The effect of physical strain on breeders patients with obstructive sleep apnea syndrome. ( 30472194 )
2018
30
Association between obstructive sleep apnea syndrome and waist-to-height ratio. ( 30238284 )
2018
31
Prevalence of childhood obstructive sleep apnea syndrome and its role in daytime sleepiness. ( 30281638 )
2018
32
Effect of Continuous Positive Airway Pressure on Overactive Bladder Symptoms in Patients with Obstructive Sleep Apnea Syndrome. ( 30319868 )
2018
33
Risk of Alzheimer's Disease in Obstructive Sleep Apnea Syndrome: Amyloid-β and Tau Imaging. ( 30320587 )
2018
34
Perinatal risk factors for obstructive sleep apnea syndrome in children. ( 30321822 )
2018
35
Effects of 12 weeks of regular aerobic exercises on autonomic nervous system in obstructive sleep apnea syndrome patients. ( 30328014 )
2018
36
Sleep and libido in men with obstructive sleep apnea syndrome. ( 30340202 )
2018
37
Efficacy of a mandibular advancement intraoral appliance (MOA) for the treatment of obstructive sleep apnea syndrome (OSAS) in pediatric patients: A pilot-study. ( 30341264 )
2018
38
Obstructive sleep apnea syndrome should always be screened in patients complaining of nocturia. ( 30350015 )
2018
39
Impaired cerebral oxygenation and exercise tolerance in patients with severe obstructive sleep apnea syndrome. ( 30099350 )
2018
40
Evaluation of Sexual Dysfunction, Lower Urinary Tract Symptoms and Quality of Life in Men With Obstructive Sleep Apnea Syndrome and the Efficacy of Continuous Positive Airway Pressure Therapy. ( 30118776 )
2018
41
Cognitive Impairment and Affective Disorders in Patients With Obstructive Sleep Apnea Syndrome. ( 30131730 )
2018
42
Auditory Deficits in Patients With Mild and Moderate Obstructive Sleep Apnea Syndrome: A Speech Syllable Evoked Auditory Brainstem Response Study. ( 30134647 )
2018
43
Fas-positive lymphocytes are associated with systemic inflammation in obstructive sleep apnea syndrome. ( 30171418 )
2018
44
Management of Obstructive Sleep Apnea Syndrome Associated with Severe Micrognathia. ( 30173692 )
2018
45
Analysis of Aortic Remodeling and Stiffness in Patients with Obstructive Sleep Apnea Syndrome: Preliminary Results. ( 30178354 )
2018
46
Efficacy of Upper Gastrointestinal Endoscopic Examination to Identify Patients with Obstructive Sleep Apnea Syndrome: A Retrospective Cross-Sectional Study. ( 30179870 )
2018
47
Evaluation of Intraocular pressure, Corneal thickness, and Retinal nerve fiber layer thickness in patients with Obstructive Sleep Apnea Syndrome. ( 30190734 )
2018
48
Significant Association Between Coronary Artery Low-Attenuation Plaque Volume and Apnea-Hypopnea Index, But Not Muscle Sympathetic Nerve Activity, in Patients With Obstructive Sleep Apnea Syndrome. ( 30197403 )
2018
49
Corrigendum: Bone Metabolic Markers in Patients with Obstructive Sleep Apnea Syndrome. ( 30203814 )
2018
50
Postoperative characteristics of combined pharyngoplasty and tonsillectomy versus tonsillectomy in children with obstructive sleep apnea syndrome. ( 30204981 )
2018

Variations for Apnea, Obstructive Sleep

Expression for Apnea, Obstructive Sleep

Search GEO for disease gene expression data for Apnea, Obstructive Sleep.

Pathways for Apnea, Obstructive Sleep

Pathways related to Apnea, Obstructive Sleep according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.48 ADIPOQ IL6 INS LEP TNF
2
Show member pathways
12 CRP IL6 INS TNF
3 11.74 EDN1 IL6 TNF
4
Show member pathways
11.72 IL6 INS TNF
5 11.67 EDN1 IL6 INS
6 11.65 EDN1 IL6 TNF
7
Show member pathways
11.62 ADIPOQ INS TNF
8 11.47 ADIPOQ IL6 INS LEP TNF
9 11.45 ADIPOQ LEP TNF
10 11.3 EDN1 IL6 TNF
11
Show member pathways
10.91 CRP EDN1 LEP
12 10.61 CRP IL6 TNF
13 10.27 ADIPOQ IL6 LEP TNF

GO Terms for Apnea, Obstructive Sleep

Cellular components related to Apnea, Obstructive Sleep according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 ADIPOQ CRP EDN1 IL6 INS LEP
2 extracellular region GO:0005576 9.28 ADIPOQ CRP EDN1 HCRT IL6 INS

Biological processes related to Apnea, Obstructive Sleep according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.98 EDN1 HTR2A IL6 INS LEP
2 response to drug GO:0042493 9.93 ADIPOQ EDN1 HTR2A REN
3 glucose homeostasis GO:0042593 9.82 ADIPOQ INS LEP
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.81 EDN1 IL6 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.79 CRP IL6 TNF
6 positive regulation of cold-induced thermogenesis GO:0120162 9.79 ADIPOQ HCRT LEP
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.77 ADIPOQ HTR2A IL6
8 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.71 INS LEP TNF
9 response to glucocorticoid GO:0051384 9.7 ADIPOQ IL6 TNF
10 cellular response to drug GO:0035690 9.69 ADIPOQ EDN1 REN
11 regulation of blood pressure GO:0008217 9.67 EDN1 LEP REN
12 negative regulation of lipid catabolic process GO:0050995 9.66 INS TNF
13 positive regulation of cellular protein metabolic process GO:0032270 9.65 ADIPOQ INS
14 positive regulation of glial cell proliferation GO:0060252 9.65 IL6 TNF
15 positive regulation of insulin receptor signaling pathway GO:0046628 9.65 INS LEP
16 positive regulation of MAP kinase activity GO:0043406 9.65 EDN1 HTR2A TNF
17 negative regulation of gluconeogenesis GO:0045721 9.63 ADIPOQ INS
18 positive regulation of protein kinase activity GO:0045860 9.63 ADIPOQ MMD TNF
19 negative regulation of glucose import GO:0046325 9.62 LEP TNF
20 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.61 ADIPOQ CRP
21 positive regulation of smooth muscle cell proliferation GO:0048661 9.61 EDN1 IL6 TNF
22 regulation of protein secretion GO:0050708 9.6 INS TNF
23 negative regulation of hormone secretion GO:0046888 9.58 ADIPOQ EDN1
24 artery smooth muscle contraction GO:0014824 9.57 EDN1 HTR2A
25 negative regulation of blood vessel diameter GO:0097756 9.56 CRP INS
26 negative regulation of potassium ion transport GO:0043267 9.55 HCRT HTR2A
27 negative regulation of fat cell differentiation GO:0045599 9.54 ADIPOQ IL6 TNF
28 response to activity GO:0014823 9.5 ADIPOQ EDN1 LEP
29 regulation of signaling receptor activity GO:0010469 9.5 ADIPOQ EDN1 HCRT IL6 INS LEP
30 glucose metabolic process GO:0006006 9.46 ADIPOQ INS LEP TNF
31 acute-phase response GO:0006953 9.43 CRP IL6 INS
32 positive regulation of neuroinflammatory response GO:0150078 9.4 IL6 TNF
33 negative regulation of lipid storage GO:0010888 8.92 CRP IL6 LEP TNF

Molecular functions related to Apnea, Obstructive Sleep according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 ADIPOQ AHI1 CENPJ CRP INS PPCDC
2 cytokine activity GO:0005125 9.46 ADIPOQ EDN1 IL6 TNF
3 insulin-like growth factor receptor binding GO:0005159 9.26 INS REN
4 hormone activity GO:0005179 8.92 ADIPOQ EDN1 INS LEP

Sources for Apnea, Obstructive Sleep

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....