Apnea of Prematurity

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Apnea of Prematurity

MalaCards integrated aliases for Apnea of Prematurity:

Name: Apnea of Prematurity 58


Orphanet epidemiological data:

apnea of prematurity
Prevalence: 1-9/100000 (Europe); Age of onset: Infancy,Neonatal;


Orphanet: 58  
Rare respiratory diseases

External Ids:

ICD10 via Orphanet 33 P28.4
UMLS via Orphanet 72 C0475715
Orphanet 58 ORPHA99981

Summaries for Apnea of Prematurity

MalaCards based summary : Apnea of Prematurity is related to cerebral palsy and gastroesophageal reflux. The drugs Theophylline and Doxapram have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and heart.

Wikipedia : 74 Apnea of prematurity is defined as cessation of breathing by a premature infant that lasts for more than... more...

Related Diseases for Apnea of Prematurity

Graphical network of the top 20 diseases related to Apnea of Prematurity:

Diseases related to Apnea of Prematurity

Symptoms & Phenotypes for Apnea of Prematurity

Drugs & Therapeutics for Apnea of Prematurity

Drugs for Apnea of Prematurity (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Theophylline Approved Phase 2, Phase 3 58-55-9 2153
Doxapram Approved, Vet_approved Phase 3 309-29-5 3156
3 Anti-Asthmatic Agents Phase 2, Phase 3
4 Vasodilator Agents Phase 2, Phase 3
5 Bronchodilator Agents Phase 2, Phase 3
6 Respiratory System Agents Phase 3
7 Hematinics Phase 1, Phase 2
8 Pharmaceutical Solutions Phase 2
9 Epoetin alfa Phase 2 113427-24-0
10 Tin Fluorides Phase 2
tannic acid Approved 1401-55-4
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
Acetaminophen Approved 103-90-2 1983
14 Chelating Agents
15 Anticoagulants
16 Calcium, Dietary
17 Calamus
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show all 50)
# Name Status NCT ID Phase Drugs
1 Magnetic Resonance Imaging and Neurodevelopmental Outcomes in Preterm Infants Following Administration of High-Dose Caffeine - A Pilot Study Completed NCT00809055 Phase 4 Caffeine citrate
2 A Randomized, Placebo-controlled Trial of Early Caffeine in Preterm Neonates Recruiting NCT03086473 Phase 4 Caffeine Citrate;Placebo (Normal Saline)
3 A Phase III Clinical Study of NPC-11 in the Treatment of Apnea of Prematurity. - Investigation of Safety, Efficacy and Pharmacokinetics of Caffeine Citrate - Completed NCT01408173 Phase 3 NPC-11 for intravenous or oral administration.
4 Long-Term Effects On Sleep Of Methylxanthine Therapy For Apnea Of Prematurity Completed NCT01020357 Phase 3 Caffeine citrate injection;placebo
5 High Versus Low Dose of Caffeine for Apnea of Prematurity: A Double Blind Randomized Control Trial Completed NCT02103777 Phase 3 Caffeine citrate
6 CO2 Inhalation as a New Treatment Modality for Apnea of Prematurity Completed NCT01066728 Phase 2, Phase 3 Theophylline
7 A Randomized, Controlled Trial of Synchronized Nasal Intermittent Positive Pressure Ventilation Versus Nasal Continuous Positive Airway Pressure Using the Infant Flow Advance to Facilitate Successful Extubation in Premature Infants. Completed NCT00188968 Phase 3
8 Efficacy and Safety of Methylxanthines in Very Low Birthweight Infants Completed NCT00182312 Phase 3 Caffeine citrate injection
9 Pilot Study of Effects of Caffeine on Intermittent Hypoxia in Infants Born Preterm Completed NCT01875159 Phase 3 Caffeine citrate 6 mg/kg/day
10 Observational, Cross-over Study of the Positive Distending Pressure Generated by Humidified High Flow Nasal Cannula as Compared to Nasal Continuous Positive Airway Pressure Completed NCT00356668 Phase 3
11 Randomized Controlled Trial of Home Therapy With Caffeine Citrate in Moderately Preterm Infants With Apnea of Prematurity Recruiting NCT03340727 Phase 3 Caffeine Citrate;Placebo
12 Doxapram Versus Placebo in Preterm Newborns: An International Double Blinded Multicenter Randomized Controlled Trial Not yet recruiting NCT04430790 Phase 3 Doxapram;Placebo
13 A Prospective, Controlled Trial of Inhalation of Low Concentration of CO2 in Preterm Infants Not Responding to Caffeine for the Treatment of Apnea of Prematurity Terminated NCT01911182 Phase 2, Phase 3
14 Early Treatment With Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants: Comparison of High and Low Dose Unknown status NCT00910234 Phase 1, Phase 2 recombinant human erythropoietin (rhEpo);recombinant human erythropoietin (rhEpo);Normal saline
15 Erythropoietin in Premature Infants to Prevent Encephalopathy: A Multi-Centre Randomized Blinded Controlled Study of the Efficacy of Erythropoietin in China Recruiting NCT02550054 Phase 2 Epo;Normal saline
16 Intermittent Hypoxia and Caffeine in Infants Born Preterm (ICAF) Recruiting NCT03321734 Phase 2 Caffeine;Placebos
17 Management of Apnea in Late Preterm and Term Infants Withdrawn NCT02408328 Phase 2 Caffeine citrate
18 High Versus Low Dose Caffeine as Respiratory Stimulant in Preterm Infants Recruiting NCT04144712 Phase 1 Caffeine Citrate
19 Population Pharmacokinetics and Metabolomic Analysis of Aminopylline/Theophylline Drug Levels in Preterm Infants With Apnea of Prematurity Unknown status NCT01509248
20 Caffeine for Preterm Infants With Apnea of Prematurity(AOP): a Randomized Controlled Trial Unknown status NCT03298347 80mg/kg of caffeine;20mg/kg of caffeine
21 Prophylactic Versus Therapeutic Caffeine for Apnea of Prematurity Unknown status NCT02677584 Prophylactic caffeine citrate;Therapeutic caffeine citrate
22 A Randomized Double Blind Controlled Trial of Early Versus Late Caffeine for Extremely Low Birth Weight Newborns Unknown status NCT02524249 Caffeine;Placebo (dextrose)
23 Stochastic Resonance Mattress (Physiological Interventions) and Biomarkers for Enhancing Neonatal Health Completed NCT01643057
24 Effect of Three-Stair-Position on Improvement of Apnea of Prematurity and Feeding Performance in Prematurity: A Randomized Control Trial Completed NCT02346864
25 Effect of Feedings on Caffeine Pharmacokinetics and Metabolism in Premature Infants Completed NCT02293824 Caffeine
26 A Comparison of Non-invasive Ventilation Methods Used to Prevent Endotracheal Intubation Due to Apnea in Very Low Birth Weight Infants Completed NCT03298035
27 Neuromodulation of Limb Proprioceptive Afferents Using a Vibratory Device to Decrease Apnea, Intermittent Hypoxia and Bradycardia of Prematurity. Completed NCT02641249
28 A Comparison of Methods of Discontinuing Nasal CPAP in Premature Infants <30 Weeks Gestation - a Feasibility Study Completed NCT03292562
29 A Randomized Controlled Trial of Nasal Intermittent Positive Pressure Ventilation Versus Nasal Continuous Positive Pressure as a Primary Mode for Respiratory Distress Syndrome in Preterm Infants Completed NCT00821119
30 Intermittent Hypoxemia and Acute Kidney Injury Study (IHAKI Study) Completed NCT02837276
31 Determining an Optimal Weaning Method of Nasal Continuous Positive Airway Pressure in Preterm Neonates Completed NCT02064712
32 Cardiovascular and Cerebrovascular Responses to Cardio-respiratory Events in Very Preterm Infants During the Transitional Period Completed NCT04184245
33 Caffeine Citrate for the Treatment of Apnea Associated With Bronchiolitis in Young Infants: A Randomized, Double Blind, Controlled Trial (RCT) Completed NCT01435486 Caffeine citrate;Normal saline
34 Cardio-respiratory Events in VLBW Preterm Infants During the Transitional Period: Clinical Features and Impact of Neonatal Characteristics. Completed NCT04123691
35 Impact of Arterial Oxygen Saturation Range on Ventilatory Stability in Extremely Premature Infants Recruiting NCT03695900
36 Prematurity-Related Ventilatory Control (PRE-VENT): Role in Respiratory Outcomes Clinical Research Centers (CRC) Recruiting NCT03333161
37 Prematurity-Related Ventilatory Control (PRE-VENT): Role in Respiratory Outcomes Clinical Research Centers (CRC) - Specific Aim 3 Recruiting NCT03333174
38 The Effect of Standardizing the Definition and Approach to a Clinically Significant Cardiopulmonary Event in Infants Less Than 30 Weeks on Length of Stay Recruiting NCT03414671
39 Automatic Oxygen Control (SPOC) in Preterm Infants - Evaluation of a Revised Algorithm and Effect of Averaging Time of Pulse Oximetry Signal Recruiting NCT03785899
40 Apnea Treatment in Premature Infants Using an Automatic Vibro-tactile Stimulator Triggered by the Detection of Apnea-bradycardia. Recruiting NCT03651648
41 Physiologic Biomarkers Predicting Ventilatory Instability and Hypoxemia in Pre Mature Infants Recruiting NCT03464396
42 Adaptive Dynamic Inspiratory Nasal Apparatus (ADINA): Comparison to High Flow Nasal Cannula (HFNC) Not yet recruiting NCT03171129
43 Effect of High Frequency Oscillatory Highflow Nasal Cannula on Desaturations and Bradycardia in Preterm Infants: A Randomized Crossover Trial Not yet recruiting NCT04327466
44 Influence of Caffeine Therapy in Preterm Infants on Sleep and Neurodevelopmental Outcomes During the First Year of Life: a Single Center Experience Not yet recruiting NCT04376749
45 Automatic Oxygen Control for Reducing Extremes of Oxygen Saturation (AreOS): A Randomised Control Trial Not yet recruiting NCT04223258
46 Randomized Trial Investigating Four Nasal CPAP Systems in the Management of Apnea of Prematurity Terminated NCT00482040
47 Effectiveness of an Oral Sucrose Solution in Reducing Pain and Anxiety Associated With Neonatal Ophthalmologic Examination Terminated NCT00161694
48 Does the Use of Caffeine Post Discharge Normalize the Respiratory Patterns in Infants Born Earlier Than 35 Weeks? A Cohort Study Terminated NCT02386046
49 Use of Caffeine to Reduce Length of Mechanical Ventilation in Preterm Infants Terminated NCT01751724 Caffeine citrate
50 Pulmonary Function During Prone and Supine Positioning in Neonatal Intensive Care Unit (NICU) Infants Requiring Assisted Ventilation Withdrawn NCT00749762

Search NIH Clinical Center for Apnea of Prematurity

Genetic Tests for Apnea of Prematurity

Anatomical Context for Apnea of Prematurity

MalaCards organs/tissues related to Apnea of Prematurity:

Brain, Kidney, Heart, Lung, Breast, Monocytes, Eye

Publications for Apnea of Prematurity

Articles related to Apnea of Prematurity:

(show top 50) (show all 445)
# Title Authors PMID Year
Central Apnea of Prematurity: Does Sex Matter? 61
32578186 2020
Caffeine preserves quiet sleep in preterm neonates. 61
32412185 2020
Caffeine for the Treatment of Apnea in the Neonatal Intensive Care Unit: A Systematic Overview of Meta-Analyses. 61
32488731 2020
[Caffeine, the most frequently consumed psychostimulant: a narrative review article]. 61
31610604 2020
Nasal continuous positive airway pressure versus noninvasive NAVA in preterm neonates with apnea of prematurity: a pilot study with a novel approach. 61
32218494 2020
Mechanistic actions of oxygen and methylxanthines on respiratory neural control and for the treatment of neonatal apnea. 61
31626973 2020
Stopping caffeine in premature neonates: how long does it take for the level of caffeine to fall below the therapeutic range? 61
32079435 2020
Monitoring of Infants Discharged Home with Medical Devices. 61
32045488 2020
Reducing Variation in the Management of Apnea of Prematurity in the Intensive Care Nursery. 61
31941760 2020
Caffeine Citrate for Apnea of Prematurity: A Prospective, Open-Label, Single-Arm Study in Chinese Neonates. 61
32219085 2020
In utero development of fetal breathing movements in C57BL6 mice. 61
31505274 2020
Long-term facilitation of catecholamine secretion from adrenal chromaffin cells of neonatal rats by chronic intermittent hypoxia. 61
31483699 2019
NAVA-synchronized compared to nonsynchronized noninvasive ventilation for apnea, bradycardia, and desaturation events in VLBW infants. 61
31373180 2019
Caffeine Therapy in Preterm Infants: The Dose (and Timing) Make the Medicine. 61
31712401 2019
Erythropoietin and caffeine exert similar protective impact against neonatal intermittent hypoxia: Apnea of prematurity and sex dimorphism. 61
31254520 2019
Caffeine and Clinical Outcomes in Premature Neonates. 61
31653108 2019
Caffeine is associated with improved alveolarization and angiogenesis in male mice following hyperoxia induced lung injury. 61
31362742 2019
Caffeine inhibits hypoxia-induced nuclear accumulation in HIF-1α and promotes neonatal neuronal survival. 61
30822423 2019
Caffeine prevents bilirubin-induced cytotoxicity in cultured newborn rat astrocytes. 61
29295636 2019
Acute hemodynamic effects of methylxanthine therapy in preterm neonates: Effect of variations in subgroups. 61
30085175 2019
Self-reported Quality of Life at Middle School Age in Survivors of Very Preterm Birth: Results From the Caffeine for Apnea of Prematurity Trial. 61
30830144 2019
Targeting progesterone receptors in newborn males and females: From the animal model to a new perspective for the treatment of apnea of prematurity? 61
30880277 2019
Immediate and delayed decrease of long term potentiation and memory deficits after neonatal intermittent hypoxia. 61
30858028 2019
Caffeine exposure and acute kidney injury in premature infants with necrotizing enterocolitis and spontaneous intestinal perforation. 61
30415418 2019
Doxapram stimulates respiratory activity through distinct activation of neurons in the nucleus hypoglossus and the pre-Bötzinger complex. 61
30699003 2019
Preterm Infants May Better Tolerate Feeds at Temperatures Closer to Freshly Expressed Breast Milk: A Randomized Controlled Trial. 61
30720333 2019
Effect of aminophylline on the pharmacokinetics of amikacin in Sprague-Dawley rats. 61
32040456 2019
Factors affecting the efficacy and safety of aminophylline in treatment of apnea of prematurity in neonatal intensive care unit. 61
29673564 2019
Comparison of Caffeine versus Theophylline for apnea of prematurity. 61
30881407 2019
Case report of a laryngotracheal reconstruction with anterior and posterior costal cartilage graft and stent placement - Surgical technique. 61
31039513 2019
Early Caffeine Administration and Neurodevelopmental Outcomes in Preterm Infants. 61
30518670 2019
The effect of venous caffeine on the prevention of apnea of prematurity in the very preterm infants in the neonatal intensive care unit of Shahid Motahhari Hospital, Urmia, during a year. 61
30815383 2019
Impact of High-Dose Caffeine on the Preterm Ovine Cerebrum and Cerebellum. 61
31427988 2019
Doxapram Treatment and Diaphragmatic Activity in Preterm Infants. 61
30352445 2019
Neuroprotection of the preterm brain. 61
31324318 2019
Contribution of relative leptin and adiponectin deficiencies in premature infants to chronic intermittent hypoxia: Exploring a new hypothesis. 61
29246449 2018
Sleep-Disordered Breathing is Associated With Increased Mortality in Hospitalized Infants With Congenital Heart Disease. 61
30176962 2018
Caffeine: an evidence-based success story in VLBW pharmacotherapy. 61
29983414 2018
Caffeine Treatment for Apnea of Prematurity and the Influence on Dose-Dependent Postnatal Weight Gain Observed Over 15 Years. 61
30250944 2018
Caffeine for apnea of prematurity and brain development at 11 years of age. 61
30250867 2018
The effect of mechanical or electrical stimulation on apnea length in mice. 61
30603217 2018
Blood potassium and urine aldosterone after doxapram therapy for preterm infants. 61
29515224 2018
Neurobehavioral Outcomes 11 Years After Neonatal Caffeine Therapy for Apnea of Prematurity. 61
29643070 2018
Postnatal Microstructural Developmental Trajectory of Corpus Callosum Subregions and Relationship to Clinical Factors in Very Preterm Infants. 61
29765059 2018
Caffeine controversies. 61
29346141 2018
Modulation of Microglial Activation by Adenosine A2a Receptor in Animal Models of Perinatal Brain Injury. 61
30254599 2018
Myo-inositol Effects on the Developing Respiratory Neural Control System. 61
30357747 2018
Classifying Apnea of Prematurity by Transcutaneous Electromyography of the Diaphragm. 61
29190622 2018
Effect of Tactile Stimulation on Termination and Prevention of Apnea of Prematurity: A Systematic Review. 61
29552548 2018
HPLC Method for Quantification of Caffeine and Its Three Major Metabolites in Human Plasma Using Fetal Bovine Serum Matrix to Evaluate Prenatal Drug Exposure. 61
30186659 2018

Variations for Apnea of Prematurity

Expression for Apnea of Prematurity

Search GEO for disease gene expression data for Apnea of Prematurity.

Pathways for Apnea of Prematurity

GO Terms for Apnea of Prematurity

Sources for Apnea of Prematurity

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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