MCID: APC004
MIFTS: 42

Apocrine Adenocarcinoma

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Skin diseases

Aliases & Classifications for Apocrine Adenocarcinoma

MalaCards integrated aliases for Apocrine Adenocarcinoma:

Name: Apocrine Adenocarcinoma 12 15 74
Apocrine Carcinoma 12 54
Carcinoma of the Apocrine Gland 12
Carcinoma of Apocrine Gland 74
Apocrine Gland Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4933
SNOMED-CT 69 57141000

Summaries for Apocrine Adenocarcinoma

NIH Rare Diseases : 54 Apocrine carcinoma is a cancer of a sweat gland.  Apocrine carcionoma most often develops under the arm (the axilla), but it can develop on the scalp or other parts of the body.  The cause of apocrine carcinoma is unknown.  Apocrine carcinoma usually appears as a single, small, painless bump (nodule) that can vary in color and slowly increases in size.  The average age at the time of diagnosis is 62 years of age, and twice as many men are affected than women.  Most apocrine carcinomas can be treated and are not fatal.  Treatment of apocrine carcinoma is surgery to remove as much of the cancer as possible.  Additional treatments such as radiation therapy and chemotherapy have been used to treat this condition, but the usefulness of these treatments is unproven.

MalaCards based summary : Apocrine Adenocarcinoma, also known as apocrine carcinoma, is related to breast apocrine carcinoma and cystadenoma. An important gene associated with Apocrine Adenocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are Signaling by ERBB4 and FOXA1 transcription factor network. The drugs Talimogene laherparepvec and nivolumab have been mentioned in the context of this disorder. Affiliated tissues include breast, skin and lymph node, and related phenotypes are digestive/alimentary and integument

Disease Ontology : 12 An apocrine sweat gland cancer that derives from epithelial cells of glandular origin.

Related Diseases for Apocrine Adenocarcinoma

Diseases related to Apocrine Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
# Related Disease Score Top Affiliating Genes
1 breast apocrine carcinoma 34.0 ERBB2 PGR
2 cystadenoma 30.2 MUC1 PGR
3 mammary paget's disease 30.2 ERBB2 ESR1 MUC1 PGR
4 paget disease, extramammary 29.9 AR ERBB2 MUC1
5 gynecomastia 29.9 AR ESR1 PGR
6 spindle cell carcinoma 29.7 KRT5 MUC1 PGR
7 in situ carcinoma 29.7 ERBB2 ESR1 KRT5 PGR
8 lipid-rich carcinoma 29.5 ERBB2 ESR1 KRT5 PGR
9 breast ductal carcinoma 29.4 AR ERBB2 ESR1 PGR
10 breast cancer 29.3 AR ERBB2 ESR1 KRT5 MUC1 PGR
11 breast fibroadenoma 29.1 ERBB2 ESR1 KRT15 PGR
12 sweat gland cancer 29.0 ERBB2 ESR1 KRT15 KRT5 PGR
13 vulvar apocrine adenocarcinoma 12.4
14 breast apocrine carcinoma in situ 12.2
15 adenocarcinoma 10.8
16 breast mucoepidermoid carcinoma 10.3 MUC1 PGR
17 endosalpingiosis 10.3 MUC1 PGR
18 scirrhous adenocarcinoma 10.3 ERBB2 PGR
19 clear cell meningioma 10.3 MUC1 PGR
20 intracystic papillary adenoma 10.3 ERBB2 PGR
21 progesterone-receptor negative breast cancer 10.3 ERBB2 PGR
22 sulfite oxidase deficiency due to molybdenum cofactor deficiency 10.3
23 perivascular epithelioid cell tumor 10.3 MUC1 PGR
24 uterine body mixed cancer 10.3 ERBB2 PGR
25 sertoli cell tumor 10.3 MUC1 PGR
26 microglandular adenosis 10.2 ERBB2 PGR
27 dermoid cyst 10.2 MUC1 PGR
28 sertoli-leydig cell tumor 10.2 MUC1 PGR
29 syringoma 10.2 ESR1 MUC1
30 sclerosing hemangioma 10.2 MUC1 PGR
31 pancreatic mucinous cystadenoma 10.2 MUC1 PGR
32 chickenpox 10.2 MUC1 PGR
33 leiomyomatosis 10.2 ESR1 PGR
34 myoma 10.2 ESR1 PGR
35 comedo carcinoma 10.2 ERBB2 ESR1
36 corneal abscess 10.2 AR PGR
37 bartholin's gland disease 10.2 AR PGR
38 vestibular gland benign neoplasm 10.2 ESR1 PGR
39 bartholin's gland adenoma 10.2 ESR1 PGR
40 complete androgen insensitivity syndrome 10.2 AR MUC1
41 vulvar syringoma 10.2 ESR1 PGR
42 lung leiomyoma 10.2 ESR1 PGR
43 vulvar benign neoplasm 10.2 ESR1 PGR
44 trigonitis 10.2 ESR1 PGR
45 vulvar leiomyoma 10.2 ESR1 PGR
46 papillary hidradenoma 10.2 AR PGR
47 predominantly cortical thymoma 10.2 ESR1 PGR
48 mixed cell type cancer 10.2 ERBB2 PGR
49 bartholin's gland benign neoplasm 10.2 ESR1 PGR
50 progesterone resistance 10.2 ESR1 PGR

Graphical network of the top 20 diseases related to Apocrine Adenocarcinoma:



Diseases related to Apocrine Adenocarcinoma

Symptoms & Phenotypes for Apocrine Adenocarcinoma

MGI Mouse Phenotypes related to Apocrine Adenocarcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.65 AR ERBB2 ESR1 KRT15 KRT5
2 integument MP:0010771 9.55 AR ERBB2 ESR1 KRT5 PGR
3 limbs/digits/tail MP:0005371 9.35 AR ERBB2 ESR1 KRT5 PGR
4 neoplasm MP:0002006 8.92 AR ERBB2 ESR1 PGR

Drugs & Therapeutics for Apocrine Adenocarcinoma

Drugs for Apocrine Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Talimogene laherparepvec Approved, Experimental, Investigational Phase 2 1187560-31-1
2
nivolumab Approved Phase 2 946414-94-4
3 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Apocrine Adenocarcinoma

Genetic Tests for Apocrine Adenocarcinoma

Anatomical Context for Apocrine Adenocarcinoma

MalaCards organs/tissues related to Apocrine Adenocarcinoma:

42
Breast, Skin, Lymph Node, Brain, Ovary

Publications for Apocrine Adenocarcinoma

Articles related to Apocrine Adenocarcinoma:

(show top 50) (show all 161)
# Title Authors Year
1
Primary Mediastinal HER2-positive Apocrine Carcinoma in Mature Teratoma Treated With Anti-HER2 Therapy and Chemoradiation. ( 30804140 )
2019
2
Mixed pleomorphic lobular and apocrine carcinoma of the breast: A case report suggesting pathogenesis. ( 30811750 )
2019
3
Metastatic cutaneous apocrine adenocarcinoma responsive to the programmed cell death protein 1A inhibitor pembrolizumab. ( 29237537 )
2018
4
A case report of a primary apocrine adenocarcinoma of the eyelid with literature review. ( 29313402 )
2018
5
Metastatic cutaneous apocrine carcinoma: a multidisciplinary approach incorporating endocrine therapy. ( 29952286 )
2018
6
A clinicopathologic study of invasive apocrine carcinoma of the breast: A single-center experience. ( 30240079 )
2018
7
Apocrine lesions of the breast: part 2 of a two-part review. Invasive apocrine carcinoma, the molecular apocrine signature and utility of immunohistochemistry in the diagnosis of apocrine lesions of the breast. ( 30425121 )
2018
8
Primary cutaneous apocrine carcinoma arising within a nevus sebaceus. ( 30489554 )
2018
9
Bilateral metachronous cutaneous apocrine carcinoma with reduced PTEN expression. ( 29619986 )
2018
10
Primary cutaneous cribriform apocrine carcinoma: Case report and literature review. ( 29735815 )
2018
11
Apocrine Adenocarcinoma Occurring on the Chin. ( 28331425 )
2017
12
A Rare Case of Primary Apocrine Adenocarcinoma Arising Within a Mature Cystic Teratoma of the Ovary, Metastatic to a Supraclavicular Lymph Node. ( 28787321 )
2017
13
Dose invasive apocrine adenocarcinoma has worse prognosis than invasive ductal carcinoma of breast: evidence from SEER database. ( 28445946 )
2017
14
Apocrine carcinoma of the breast: A brief update on the molecular features and targetable biomarkers. ( 28027454 )
2017
15
Successful Treatment of Advanced Primary Cutaneous Apocrine Carcinoma on the Scrotum with Systemic Chemotherapy and Radiotherapy Followed by Denosumab. ( 28203164 )
2017
16
Cutaneous Apocrine Carcinoma With an In Situ Component and Histiocytoid and Signet-Ring Cells. ( 28525910 )
2017
17
Metastatic cutaneous apocrine carcinoma: Multidisciplinary approach achieving complete response with adjuvant chemoradiation. ( 28580412 )
2017
18
Apocrine carcinoma with neuroendocrine differentiation. ( 28671291 )
2017
19
Apocrine carcinoma of breast: A rare entity posing cytological challenge. ( 28940892 )
2017
20
Primary apocrine carcinoma of an unusual site. ( 29269369 )
2017
21
Scrotal Apocrine Adenocarcinoma with Pagetoid Phenomenon and Inguinal Lymph Node Metastases. ( 27818816 )
2016
22
Apocrine adenocarcinoma of the eyelid. ( 27500123 )
2016
23
Apocrine Adenocarcinoma of the Vulva: A Case Report and Review of the Literature. ( 27668109 )
2016
24
A Modern Approach to Differential Diagnosis Between Cutaneous Apocrine Carcinoma and Metastasis From Breast Carcinoma. ( 26825162 )
2016
25
Giant annular purpuric eruption as a unique clinical manifestation of skin metastasis in apocrine carcinoma. ( 25753374 )
2016
26
Primary apocrine carcinoma of the axilla in a male patient: a case report. ( 27099724 )
2016
27
Cutaneous apocrine carcinoma on the scalp after cranial irradiation for acute lymphocytic leukaemia. ( 27457132 )
2016
28
Primary Cutaneous Apocrine Carcinoma. ( 27746659 )
2016
29
Primary cutaneous apocrine carcinoma: 2 cases and review of the pertinent histologic findings. ( 27766305 )
2016
30
A Rare Case of Invasive Apocrine Carcinoma of the Breast with Unusual Radiologic Findings. ( 27878066 )
2016
31
Apocrine carcinoma of the vulva. Case report and review of literature. ( 29787019 )
2016
32
Axillary apocrine adenocarcinoma in a young male suspected initially on fine-needle aspiration cytology. ( 26729983 )
2015
33
Primary apocrine adenocarcinoma of the axilla. ( 26057510 )
2015
34
Metastatic Cutaneous Apocrine Adenocarcinoma Treated With a Combination of Pertuzumab-Based Targeted Therapy and Taxane Chemotherapy: A Case Report. ( 26375389 )
2015
35
Primary apocrine adenocarcinoma of scrotum suspected as urothelial carcinoma metastasis: A clinical and pathological dilemma. ( 25657556 )
2015
36
Unusual apocrine carcinoma with neuroendocrine differentiation: a cutaneous neoplasm may be analogous to neuroendocrine carcinoma with apocrine differentiation of breast. ( 26055980 )
2015
37
Apocrine Carcinoma of the Axilla Associated with Extramammary Paget's Disease: A Case Report and Review of the Literature. ( 26377183 )
2015
38
Recurrent apocrine carcinoma of the scrotum: a case report. ( 25596997 )
2015
39
Cutaneous apocrine carcinoma of the scrotum: A case with widespread subcutaneous induration. ( 25960077 )
2015
40
Large cutaneous apocrine carcinoma occurring on right thigh aggravated after moxa treatment. ( 25960994 )
2015
41
Sonography of Invasive Apocrine Carcinoma of the Breast in Five Cases. ( 26357495 )
2015
42
Apocrine carcinoma arising in a complex fibroadenoma: a case report. ( 24561707 )
2014
43
Treatment strategy for cutaneous apocrine carcinoma. ( 23900624 )
2014
44
Metastatic cutaneous apocrine carcinoma of the axilla successfully treated using systemic chemotherapy with i.v. epirubicin and cyclophosphamide followed by oral fluorinated pyrimidine. ( 24506091 )
2014
45
A rare case of apocrine carcinoma of the breast: Cytopathological and immunohistopathological study. ( 25210239 )
2014
46
Strong CA19-9 expression associated with multiple metastases in a case of apocrine carcinoma. ( 25476105 )
2014
47
Cutaneous apocrine carcinoma in groin with bilateral lymph node metastasis: a case report and review of the literature. ( 25550884 )
2014
48
Apocrine carcinoma of the male breast: a case report of an exceptional tumor. ( 25883722 )
2014
49
Apocrine adenocarcinoma of the eyelid: case series and review. ( 24217473 )
2013
50
Apocrine adenocarcinoma of the vulva. ( 24179652 )
2013

Variations for Apocrine Adenocarcinoma

Expression for Apocrine Adenocarcinoma

Search GEO for disease gene expression data for Apocrine Adenocarcinoma.

Pathways for Apocrine Adenocarcinoma

Pathways related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.17 ERBB2 ESR1 PGR
2
Show member pathways
10.82 AR ESR1
3
Show member pathways
10.75 AR ESR1 PGR

GO Terms for Apocrine Adenocarcinoma

Cellular components related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.5 AR ERBB2 ESR1 HPGD KRT15 KRT5
2 nuclear chromatin GO:0000790 8.8 AR ESR1 MUC1

Biological processes related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription initiation from RNA polymerase II promoter GO:0006367 9.5 AR ESR1 PGR
2 intracellular receptor signaling pathway GO:0030522 9.4 AR ESR1
3 transcription, DNA-templated GO:0006351 9.37 AR ESR1
4 mammary gland alveolus development GO:0060749 9.26 AR ESR1
5 steroid hormone mediated signaling pathway GO:0043401 9.13 AR ESR1 PGR
6 positive regulation of transcription by RNA polymerase III GO:0045945 8.85 AR
7 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 8.62 AR PGR

Molecular functions related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.62 AR ESR1 MUC1 PGR
2 lipid binding GO:0008289 9.54 AR ESR1 PGR
3 ATPase binding GO:0051117 9.43 AR ESR1 PGR
4 scaffold protein binding GO:0097110 9.4 KRT15 KRT5
5 steroid hormone receptor activity GO:0003707 9.33 AR ESR1 PGR
6 nuclear receptor activity GO:0004879 9.13 AR ESR1 PGR
7 steroid binding GO:0005496 8.8 AR ESR1 PGR

Sources for Apocrine Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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