MCID: APC004
MIFTS: 37

Apocrine Adenocarcinoma

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Skin diseases

Aliases & Classifications for Apocrine Adenocarcinoma

MalaCards integrated aliases for Apocrine Adenocarcinoma:

Name: Apocrine Adenocarcinoma 12 15 70
Apocrine Carcinoma 12 20
Carcinoma of the Apocrine Gland 12
Carcinoma of Apocrine Gland 70
Apocrine Gland Carcinoma 12

Classifications:



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Disease Ontology 12 DOID:4933
SNOMED-CT 67 57141000
UMLS 70 C0334346 C1706827

Summaries for Apocrine Adenocarcinoma

GARD : 20 Apocrine carcinoma is a cancer of a sweat gland. Apocrine carcionoma most often develops under the arm (the axilla ), but it can develop on the scalp or other parts of the body. The cause of apocrine carcinoma is unknown. Apocrine carcinoma usually appears as a single, small, painless bump ( nodule ) that can vary in color and slowly increases in size. The average age at the time of diagnosis is 62 years of age, and twice as many men are affected than women. Most apocrine carcinomas can be treated and are not fatal. Treatment of apocrine carcinoma is surgery to remove as much of the cancer as possible. Additional treatments such as radiation therapy and chemotherapy have been used to treat this condition, but the usefulness of these treatments is unproven.

MalaCards based summary : Apocrine Adenocarcinoma, also known as apocrine carcinoma, is related to vulvar apocrine adenocarcinoma and syringocystadenoma papilliferum. An important gene associated with Apocrine Adenocarcinoma is PIP (Prolactin Induced Protein), and among its related pathways/superpathways are Development EGFR signaling pathway and Integrated Breast Cancer Pathway. Affiliated tissues include breast, lung and liver, and related phenotypes are digestive/alimentary and integument

Disease Ontology : 12 An apocrine sweat gland cancer that derives from epithelial cells of glandular origin.

Related Diseases for Apocrine Adenocarcinoma

Diseases related to Apocrine Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 429)
# Related Disease Score Top Affiliating Genes
1 vulvar apocrine adenocarcinoma 31.8 PIP KRT7 KRT5 AR
2 syringocystadenoma papilliferum 30.3 SERPINA3 PIP MUC1
3 hidrocystoma 30.2 PIP KRT7
4 adenocarcinoma 30.2 MUC1 KRT7 ERBB2 EGFR
5 eyelid carcinoma 30.1 PIP KRT7
6 breast apocrine carcinoma 30.1 PIP ACSM1
7 cystic basal cell carcinoma 30.0 PIP KRT7 KRT5
8 comedo carcinoma 30.0 PGR ESR1 ERBB2
9 gynecomastia 30.0 PGR ESR1 ERBB2 AR
10 eccrine adenocarcinoma 29.9 PIP KRT7 KRT5
11 sebaceous adenocarcinoma 29.8 PIP KRT5 ERBB2 AR
12 signet ring cell adenocarcinoma 29.7 PIP MUC1 KRT7 ERBB2
13 skin benign neoplasm 29.7 SERPINA3 PIP KRT7 KRT5
14 lipid-rich carcinoma 29.7 PIP PGR KRT5 ESR1 ERBB2
15 vulva cancer 29.5 PIP KRT7 ERBB2 EGFR
16 cystadenoma 29.4 SERPINA3 PGR MUC1 KRT7 CEACAM3
17 breast fibroadenoma 29.4 SERPINA3 PGR ESR1 ERBB2 AR
18 papillary adenocarcinoma 29.3 PIP PGR MUC1 KRT7 ERBB2 CEACAM3
19 mammary paget's disease 29.1 PIP PGR MUC1 KRT7 ESR1 ERBB2
20 tubular adenocarcinoma 29.0 PGR MUC1 KRT7 ESR1 ERBB2 EGFR
21 paget disease, extramammary 28.9 PIP MUC1 KRT7 KRT5 ERBB2 CEACAM3
22 in situ carcinoma 28.9 SERPINA3 PIP PGR MUC1 KRT5 ESR1
23 ductal carcinoma in situ 28.8 PIP PGR MUC1 KRT5 ESR1 ERBB2
24 apocrine sweat gland neoplasm 28.8 PIP PGR KRT7 KRT5 ESR1 ERBB2
25 adenoid cystic carcinoma 28.8 SERPINA3 PGR MUC1 KRT7 KRT5 ERBB2
26 breast adenocarcinoma 28.7 SERPINA3 PIP PGR KRT7 ESR1 ERBB2
27 skin carcinoma 28.7 PIP PGR KRT7 KRT5 ESR1 ERBB2
28 cribriform carcinoma 28.6 PIP PGR KRT7 KRT5 GATA3 ESR1
29 breast ductal carcinoma 28.2 PIP PGR MUC1 KRT7 KRT5 ESR1
30 sweat gland cancer 28.1 PIP PGR KRT7 KRT5 GATA3 ESR1
31 breast apocrine carcinoma in situ 11.2
32 vulvar eccrine porocarcinoma 10.4 PIP MUC1
33 nodular hidradenoma 10.4 PIP MUC1
34 aggressive digital papillary adenocarcinoma 10.4 MUC1 CEACAM3
35 sinonasal undifferentiated carcinoma 10.4 MUC1 CEACAM3
36 glycogen-rich clear cell breast carcinoma 10.4 PIP PGR
37 lung sarcomatoid carcinoma 10.3 MUC1 CEACAM3
38 endometrial mucinous adenocarcinoma 10.3 PGR MUC1
39 scirrhous adenocarcinoma 10.3 PGR ERBB2
40 apocrine adenosis of breast 10.3 PGR ERBB2
41 luminal breast carcinoma b 10.3 PGR ERBB2
42 liver adenomatosis 10.3 PGR AR
43 transitional meningioma 10.3 PGR MUC1
44 bartholin's gland adenoma 10.3 PGR ESR1
45 uterine corpus adenosarcoma 10.3 PGR ESR1
46 bartholin's gland benign neoplasm 10.3 PGR ESR1
47 vestibular gland benign neoplasm 10.3 PGR ESR1
48 granulomatous endometritis 10.3 PGR ESR1
49 polymorphous low-grade adenocarcinoma 10.3 MUC1 CEACAM3
50 lung leiomyoma 10.3 PGR ESR1

Graphical network of the top 20 diseases related to Apocrine Adenocarcinoma:



Diseases related to Apocrine Adenocarcinoma

Symptoms & Phenotypes for Apocrine Adenocarcinoma

MGI Mouse Phenotypes related to Apocrine Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.7 AR EGFR ERBB2 ESR1 GATA3 KRT5
2 integument MP:0010771 9.56 AR EGFR ERBB2 ESR1 GATA3 KRT5
3 limbs/digits/tail MP:0005371 9.1 AR EGFR ERBB2 ESR1 KRT5 PGR

Drugs & Therapeutics for Apocrine Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Apocrine Adenocarcinoma

Genetic Tests for Apocrine Adenocarcinoma

Anatomical Context for Apocrine Adenocarcinoma

MalaCards organs/tissues related to Apocrine Adenocarcinoma:

40
Breast, Lung, Liver, Ovary, Prostate, Salivary Gland, Kidney

Publications for Apocrine Adenocarcinoma

Articles related to Apocrine Adenocarcinoma:

(show top 50) (show all 377)
# Title Authors PMID Year
1
Malignant Adnexal Cutaneous Tumors and Role of Sentinel Lymph Node Biopsy. 61
33727135 2021
2
Chromosome X aneusomy and androgen receptor gene copy number aberrations in apocrine carcinoma of the breast. 61
33534004 2021
3
Clinicopathological characteristics and prognostic marker of triple-negative breast cancer in older women. 61
33548251 2021
4
Clinicopathological characteristics, practical treatments, prognosis, and clinical issues of older breast cancer patients in Japan. 61
33219915 2021
5
Potential role of significant GATA3 mutation in male breast cancer responding to endocrine therapy: A case report. 61
33433431 2021
6
Primary adenocarcinomas of the vulva and related structures: An enigmatic and diverse group of tumorsāœ°. 61
33032903 2021
7
Primary Cutaneous Cribriform Apocrine Carcinoma. 61
33386383 2021
8
Primary cutaneous apocrine carcinoma: Case report and literature review. 61
33433438 2021
9
Invasive apocrine carcinoma of the breast: clinicopathologic features and comprehensive genomic profiling of 18 pure triple-negative apocrine carcinomas. 61
32504034 2020
10
Neoadjuvant targeted therapy for apocrine carcinoma of the breast: A case report. 61
33344602 2020
11
Metastatic cutaneous apocrine adenocarcinoma successfully treated with systemic anti-androgen therapy-A case report. 61
33363954 2020
12
A rare case of perianal apocrine adenocarcinoma. 61
33269071 2020
13
Cervical lymphocele: A rare complication following salvage surgery for ocular adnexal apocrine adenocarcinoma. A case report and review of the literature. 61
33252115 2020
14
Triple-negative apocrine carcinoma: A rare pathologic subtype with a better prognosis than other triple-negative breast cancers. 61
32668059 2020
15
Histo- and clinico-pathological analysis of a large series of triple-negative breast cancer in a single center in China: Evidences on necessity of histological subtyping and grading. 61
33223753 2020
16
Primary apocrine adenocarcinoma of the lacrimal sac: an extremely rare variant of lacrimal sac neoplasm. 61
32964761 2020
17
A clinical, pathological and immunohistochemical series of 9 cases of primary cutaneous apocrine carcinomas of the head and neck. 61
31736065 2020
18
All Benign and Malignant Apocrine Breast Lesions Over-Express Claudin 1 and 3 and Are Negative for Claudin 4. 61
31044387 2020
19
The role of histopathologic testing on apocrine carcinoma of the breast. 61
31521370 2020
20
Author's reply on letter to editor "Apocrine carcinoma is the fact" by Vranic S. 61
31680374 2020
21
Letter to Editor: Apocrine carcinoma is the fact. Comment on the recent paper entitled "Invasive apocrine carcinoma of the breast: Myth or fact?" by Gurrado et al (Breast J. 2019;26(3):545-546.). 61
31680383 2020
22
Invasive apocrine carcinoma of the breast: Myth or fact? 61
31495033 2020
23
Multiplex PCR analysis of apocrine lesions shows frequent PI3K-AKT pathway mutations in both benign and malignant apocrine breast tumors. 61
31139940 2020
24
High Ki-67 expression is a marker of poor survival in apocrine breast carcinoma. 61
32729301 2020
25
Co-occurrence of apocrine adenocarcinoma and invasive mammary-type ductal carcinoma in extramammary Paget disease of the axilla. 61
31964128 2020
26
Prognosis in triple-negative apocrine carcinomas of the breast: A population-based study. 61
31642210 2019
27
Deep and sustained radiological response after MEK-RAF inhibition in HRAS mutant apocrine carcinoma of the scalp. 61
31600639 2019
28
Apocrine carcinoma of the scalp with neck lymph node metastasis: A case report and review of the literature. 61
31803688 2019
29
Cutaneous apocrine carcinoma with elevated serum cytokeratin 19 fragment 21-1 (CYFRA 21-1). 61
31087578 2019
30
[Use of Vacuum-Assisted Closure Therapy in the Treatment of Postoperative Inguinal Lymphocele after Lymphadenectomy for a Vulvar Apocrine Adenocarcinoma : A Case Report]. 61
31501398 2019
31
Primary apocrine adenocarcinoma of caruncle in an elderly male. 61
31109498 2019
32
Apocrine adenocarcinoma in the setting of apocrine hidrocystoma of the leg. 61
31329389 2019
33
Periocular Sebaceous Carcinoma With Apocrine Differentiation: A Case Report and Review of the Literature. 61
30522363 2019
34
Heterogeneity of PD-L1 expression and CD8 tumor-infiltrating lymphocytes among subtypes of cutaneous adnexal carcinomas. 61
30953116 2019
35
Mixed pleomorphic lobular and apocrine carcinoma of the breast: A case report suggesting pathogenesis. 61
30811750 2019
36
Apocrine adenocarcinoma of the eyelid: case report and literature review on management. 61
31220897 2019
37
Neo-adjuvant treatment in invasive apocrine carcinoma of the breast. 61
30980572 2019
38
Granular cell tumour of the breast in a young female: A case report and literature review. 61
31089034 2019
39
[A Case of an Elderly Individual with Breast Cancer Diagnosed as Paget's Disease after Mastectomy]. 61
31164545 2019
40
Primary Mediastinal HER2-positive Apocrine Carcinoma in Mature Teratoma Treated With Anti-HER2 Therapy and Chemoradiation. 61
30804140 2019
41
Apocrine lesions of the breast: part 1 of a two-part review: benign, atypical and in situ apocrine proliferations of the breast. 61
30409840 2019
42
Apocrine lesions of the breast: part 2 of a two-part review. Invasive apocrine carcinoma, the molecular apocrine signature and utility of immunohistochemistry in the diagnosis of apocrine lesions of the breast. 61
30425121 2019
43
Overlooked adenocarcinoma of the scalp. 61
30489387 2018
44
[A Case of Apocrine Carcinoma in the Breast That Was Difficult to Distinguish from Axillary Apocrine Adenocarcinoma]. 61
30692411 2018
45
[A Case of Apocrine Carcinoma of the Breast]. 61
30692456 2018
46
A clinicopathologic study of invasive apocrine carcinoma of the breast: A single-center experience. 61
30240079 2018
47
Hierarchical Cluster Analysis of Cytokeratins and Stem Cell Expression Profiles of Canine Cutaneous Epithelial Tumors. 61
30071783 2018
48
A case report of a primary apocrine adenocarcinoma of the eyelid with literature review. 61
29313402 2018
49
Primary cutaneous apocrine carcinoma arising within a nevus sebaceus. 61
30489554 2018
50
Triple Negative Apocrine Carcinomas as a Distinct Subtype of Triple Negative Breast Cancer: A Case-control Study. 61
29573977 2018

Variations for Apocrine Adenocarcinoma

Expression for Apocrine Adenocarcinoma

Search GEO for disease gene expression data for Apocrine Adenocarcinoma.

Pathways for Apocrine Adenocarcinoma

GO Terms for Apocrine Adenocarcinoma

Cellular components related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.36 SERPINA3 PIP PGR MUC1 KRT7 KRT5

Biological processes related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 male gonad development GO:0008584 9.5 GATA3 ESR1 AR
2 intracellular estrogen receptor signaling pathway GO:0030520 9.46 ESR1 AR
3 positive regulation of protein kinase B signaling GO:0051897 9.46 GATA3 ESR1 ERBB2 EGFR
4 cellular response to estrogen stimulus GO:0071391 9.43 ESR1 AR
5 mammary gland alveolus development GO:0060749 9.4 ESR1 AR
6 uterus development GO:0060065 9.37 GATA3 ESR1
7 negative regulation of ERBB signaling pathway GO:1901185 9.26 ERBB2 EGFR
8 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 8.96 PGR AR
9 intracellular steroid hormone receptor signaling pathway GO:0030518 8.8 PGR ESR1 AR

Molecular functions related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.71 PGR GATA3 ESR1 AR
2 enzyme binding GO:0019899 9.67 PGR ESR1 EGFR AR
3 nuclear receptor activity GO:0004879 9.33 PGR ESR1 AR
4 nitric-oxide synthase regulator activity GO:0030235 9.32 ESR1 EGFR
5 RNA polymerase II transcription coactivator binding GO:0001225 9.26 PGR AR
6 steroid binding GO:0005496 9.13 PGR ESR1 AR
7 ATPase binding GO:0051117 8.92 PGR ESR1 EGFR AR

Sources for Apocrine Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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