MCID: APC004
MIFTS: 37

Apocrine Adenocarcinoma

Categories: Rare diseases, Skin diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Apocrine Adenocarcinoma

MalaCards integrated aliases for Apocrine Adenocarcinoma:

Name: Apocrine Adenocarcinoma 12 15 73
Apocrine Carcinoma 12 53
Carcinoma of the Apocrine Gland 12
Carcinoma of Apocrine Gland 73
Apocrine Gland Carcinoma 12

Classifications:



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Disease Ontology 12 DOID:4933
SNOMED-CT 68 57141000

Summaries for Apocrine Adenocarcinoma

NIH Rare Diseases : 53 Apocrine carcinoma is a cancer of a sweat gland.  Apocrine carcionoma most often develops under the arm (the axilla), but it can develop on the scalp or other parts of the body.  The cause of apocrine carcinoma is unknown.  Apocrine carcinoma usually appears as a single, small, painless bump (nodule) that can vary in color and slowly increases in size.  The average age at the time of diagnosis is 62 years of age, and twice as many men are affected than women.  Most apocrine carcinomas can be treated and are not fatal.  Treatment of apocrine carcinoma is surgery to remove as much of the cancer as possible.  Additional treatments such as radiation therapy and chemotherapy have been used to treat this condition, but the usefulness of these treatments is unproven.

MalaCards based summary : Apocrine Adenocarcinoma, also known as apocrine carcinoma, is related to breast apocrine carcinoma and vulva adenocarcinoma. An important gene associated with Apocrine Adenocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are Cytoskeletal Signaling and Signaling by ERBB4. Affiliated tissues include skin, lymph node and breast, and related phenotypes are integument and limbs/digits/tail

Disease Ontology : 12 An apocrine sweat gland cancer that derives from epithelial cells of glandular origin.

Related Diseases for Apocrine Adenocarcinoma

Diseases related to Apocrine Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)
# Related Disease Score Top Affiliating Genes
1 breast apocrine carcinoma 34.3 ERBB2 PGR
2 vulva adenocarcinoma 30.7 ERBB2 KRT7
3 cystadenoma 29.9 KRT7 MUC1 PGR
4 gynecomastia 29.8 AR ESR1 PGR
5 vulvar apocrine adenocarcinoma 12.2
6 breast apocrine carcinoma in situ 12.0
7 clear cell meningioma 10.7 MUC1 PGR
8 scirrhous adenocarcinoma 10.7 ERBB2 PGR
9 perivascular epithelioid cell tumor 10.7 MUC1 PGR
10 intracystic papillary adenoma 10.6 ERBB2 PGR
11 progesterone-receptor negative breast cancer 10.6 ERBB2 PGR
12 adenocarcinoma 10.6
13 uterine body mixed cancer 10.6 ERBB2 PGR
14 chickenpox 10.6 MUC1 PGR
15 microglandular adenosis 10.6 ERBB2 PGR
16 solid adenocarcinoma with mucin production 10.6 KRT7 MUC1
17 parachordoma 10.5 KRT7 MUC1
18 mucinous bronchioloalveolar adenocarcinoma 10.5 KRT7 MUC1
19 nodular hidradenoma 10.5 KRT7 MUC1
20 vulvar syringoma 10.5 ESR1 PGR
21 lung leiomyoma 10.5 ESR1 PGR
22 vestibular gland benign neoplasm 10.5 ESR1 PGR
23 bartholin's gland adenoma 10.5 ESR1 PGR
24 bile duct cystadenocarcinoma 10.5 KRT7 MUC1
25 vulvar benign neoplasm 10.5 ESR1 PGR
26 trigonitis 10.5 ESR1 PGR
27 vulvar leiomyoma 10.5 ESR1 PGR
28 papillary hidradenoma 10.5 AR PGR
29 monophasic synovial sarcoma 10.5 KRT7 MUC1
30 predominantly cortical thymoma 10.5 ESR1 PGR
31 nephrogenic adenoma 10.5 KRT7 MUC1
32 adenomyoma 10.5 KRT7 MUC1
33 progesterone resistance 10.5 ESR1 PGR
34 complete androgen insensitivity syndrome 10.5 AR MUC1
35 syringoma 10.5 ESR1 MUC1
36 spiradenoma 10.5 KRT7 MUC1
37 female reproductive endometrioid cancer 10.5 KRT7 PGR
38 mucinous ovarian cystadenoma 10.5 KRT7 MUC1
39 gastric signet ring cell adenocarcinoma 10.5 ESR1 PGR
40 benign metastasizing leiomyoma 10.5 KRT7 PGR
41 hidradenoma 10.5 KRT7 MUC1
42 bartholin's gland benign neoplasm 10.5 ESR1 PGR
43 deep angioma 10.5 ESR1 PGR
44 pancreatic serous cystadenoma 10.5 KRT7 PGR
45 well-differentiated liposarcoma 10.5 KRT7 MUC1
46 synchronous bilateral breast carcinoma 10.5 ESR1 PGR
47 ampulla of vater neoplasm 10.5 KRT7 MUC1
48 papillary serous adenocarcinoma 10.5 KRT7 PGR
49 appendix cancer 10.5 KRT7 MUC1
50 comedo carcinoma 10.5 ERBB2 ESR1

Graphical network of the top 20 diseases related to Apocrine Adenocarcinoma:



Diseases related to Apocrine Adenocarcinoma

Symptoms & Phenotypes for Apocrine Adenocarcinoma

MGI Mouse Phenotypes related to Apocrine Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.35 AR ERBB2 ESR1 KRT5 PGR
2 limbs/digits/tail MP:0005371 9.02 AR ERBB2 ESR1 KRT5 PGR

Drugs & Therapeutics for Apocrine Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Apocrine Adenocarcinoma

Genetic Tests for Apocrine Adenocarcinoma

Anatomical Context for Apocrine Adenocarcinoma

MalaCards organs/tissues related to Apocrine Adenocarcinoma:

41
Skin, Lymph Node, Breast, Ovary

Publications for Apocrine Adenocarcinoma

Articles related to Apocrine Adenocarcinoma:

(show all 45)
# Title Authors Year
1
Metastatic cutaneous apocrine adenocarcinoma responsive to the programmed cell death protein 1A inhibitor pembrolizumab. ( 29237537 )
2018
2
A case report of a primary apocrine adenocarcinoma of the eyelid with literature review. ( 29313402 )
2018
3
Apocrine Adenocarcinoma Occurring on the Chin. ( 28331425 )
2017
4
A Rare Case of Primary Apocrine Adenocarcinoma Arising Within a Mature Cystic Teratoma of the Ovary, Metastatic to a Supraclavicular Lymph Node. ( 28787321 )
2017
5
Dose invasive apocrine adenocarcinoma has worse prognosis than invasive ductal carcinoma of breast: evidence from SEER database. ( 28445946 )
2017
6
Scrotal Apocrine Adenocarcinoma with Pagetoid Phenomenon and Inguinal Lymph Node Metastases. ( 27818816 )
2016
7
Apocrine adenocarcinoma of the eyelid. ( 27500123 )
2016
8
Apocrine Adenocarcinoma of the Vulva: A Case Report and Review of the Literature. ( 27668109 )
2016
9
Axillary apocrine adenocarcinoma in a young male suspected initially on fine-needle aspiration cytology. ( 26729983 )
2015
10
Primary apocrine adenocarcinoma of the axilla. ( 26057510 )
2015
11
Metastatic Cutaneous Apocrine Adenocarcinoma Treated With a Combination of Pertuzumab-Based Targeted Therapy and Taxane Chemotherapy: A Case Report. ( 26375389 )
2015
12
Primary apocrine adenocarcinoma of scrotum suspected as urothelial carcinoma metastasis: A clinical and pathological dilemma. ( 25657556 )
2015
13
Apocrine adenocarcinoma of the eyelid: case series and review. ( 24217473 )
2013
14
Apocrine adenocarcinoma of the vulva. ( 24179652 )
2013
15
Case Report: Differential Diagnosis Between Primary Cutaneous Apocrine Adenocarcinoma Versus Extramammary or Metastatic Breast Adenocarcinoma. ( 23863550 )
2013
16
Cutaneous apocrine adenocarcinoma: defining epidemiology, outcomes, and optimal therapy for a rare neoplasm. ( 21913192 )
2012
17
Primary apocrine adenocarcinoma of the eyelid. ( 22571743 )
2012
18
Vulvar apocrine adenocarcinoma: a case with nodal metastasis and intranodal mucinous differentiation. ( 18842349 )
2009
19
The elusive differential diagnosis of cutaneous apocrine adenocarcinoma vs. metastasis: the current role of clinical correlation. ( 19784530 )
2009
20
Primary apocrine adenocarcinoma of the scrotum with distant metastasis: a case report. ( 19796468 )
2009
21
Apocrine adenocarcinoma of the right eyelid and apocrine adenoma of the left maxillary sinus. ( 18982051 )
2008
22
Apocrine adenocarcinoma of the nipple: a case report. ( 18700029 )
2008
23
Localised radiotherapy for a ferret with possible anal sac apocrine adenocarcinoma. ( 18631226 )
2008
24
Invasive primary ductal apocrine adenocarcinoma of axilla: a case report with immunohistochemical profiling and a review of literature. ( 18713586 )
2008
25
Infiltrating apocrine adenocarcinoma with extramammary pagetoid spread. ( 17375797 )
2007
26
Apocrine adenocarcinoma of possible sweat gland origin in a male rabbit. ( 16961473 )
2006
27
Perianal apocrine adenocarcinoma arising in a benign apocrine adenoma; first case report and review of the literature. ( 15677547 )
2005
28
Apocrine adenocarcinoma of the nipple: a case report. ( 15469170 )
2004
29
Primary apocrine adenocarcinoma with neuroendocrine differentiation occurring on the pubic skin. ( 14996118 )
2004
30
Aspiration biopsy in a case of apocrine adenocarcinoma with foam cells (myoblastomatoid or histiocytoid adenocarcinoma). ( 11992376 )
2002
31
Apocrine adenocarcinoma of the eyelid with aggressive biological behavior: report of a case. ( 11940224 )
2002
32
Apocrine adenocarcinoma in a golden hamster. ( 11767064 )
2001
33
Radiologic case study. Apocrine adenocarcinoma. ( 9845457 )
1998
34
Apocrine adenocarcinoma presenting as a large ulcerated axillary mass. ( 9236879 )
1997
35
Parathyroid hormone/parathyroid hormone-related protein receptor expression in nude mice with a transplantable canine apocrine adenocarcinoma (CAC-8) and humoral hypercalcaemia of malignancy. ( 9135577 )
1997
36
A case of apocrine adenocarcinoma associated with hamartomatous apocrine gland hyperplasia of both axillae. ( 8037297 )
1994
37
Apocrine adenocarcinoma arising in cystic teratoma of the ovary. ( 8503739 )
1993
38
Apocrine adenocarcinoma arising in Moll gland cystadenoma. ( 8233400 )
1993
39
Complex adnexal tumor of the primary epithelial germ with distinct patterns of superficial epithelioma with sebaceous differentiation, immature trichoepithelioma, and apocrine adenocarcinoma. ( 1510222 )
1992
40
Apocrine adenocarcinoma of the bilateral axillae. ( 1785351 )
1991
41
Identification of parathyroid hormone-related protein in canine apocrine adenocarcinoma of the anal sac. ( 2345942 )
1990
42
Apocrine adenocarcinoma: case report and review of the literature. ( 2341662 )
1990
43
Extramammary Paget's disease: comparative histopathologic studies of intraductal carcinoma of the breast and apocrine adenocarcinoma. ( 2175320 )
1990
44
Apocrine adenocarcinoma of the vulva with associated Paget's disease. Diagnosis of lymph node metastases by fine needle aspiration biopsy. ( 6322492 )
1984
45
Paget's disease of the vulva with underlying apocrine adenocarcinoma and local lymph node invasion. ( 6269104 )
1981

Variations for Apocrine Adenocarcinoma

Expression for Apocrine Adenocarcinoma

Search GEO for disease gene expression data for Apocrine Adenocarcinoma.

Pathways for Apocrine Adenocarcinoma

Pathways related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.92 KRT5 KRT7 MUC1
2
Show member pathways
11.17 ERBB2 ESR1 PGR
3
Show member pathways
10.82 AR ESR1
4
Show member pathways
10.75 AR ESR1 PGR

GO Terms for Apocrine Adenocarcinoma

Cellular components related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.7 AR ERBB2 ESR1 HPGD KRT5 KRT7
2 cytoplasm GO:0005737 9.23 AR ERBB2 ESR1 HPGD KRT5 KRT7
3 nuclear chromatin GO:0000790 9.13 AR ESR1 MUC1

Biological processes related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription initiation from RNA polymerase II promoter GO:0006367 9.5 AR ESR1 PGR
2 intracellular receptor signaling pathway GO:0030522 9.37 AR ESR1
3 mammary gland alveolus development GO:0060749 9.26 AR ESR1
4 positive regulation of transcription by RNA polymerase III GO:0045945 9.16 AR ERBB2
5 steroid hormone mediated signaling pathway GO:0043401 9.13 AR ESR1 PGR
6 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 8.62 AR PGR

Molecular functions related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.62 AR ESR1 MUC1 PGR
2 lipid binding GO:0008289 9.58 AR ESR1 PGR
3 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001077 9.54 AR ESR1 PGR
4 ATPase binding GO:0051117 9.43 AR ESR1 PGR
5 steroid hormone receptor activity GO:0003707 9.33 AR ESR1 PGR
6 nuclear receptor activity GO:0004879 9.13 AR ESR1 PGR
7 steroid binding GO:0005496 8.8 AR ESR1 PGR

Sources for Apocrine Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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