MCID: APC003
MIFTS: 36

Apocrine Adenoma

Categories: Skin diseases, Cancer diseases

Aliases & Classifications for Apocrine Adenoma

MalaCards integrated aliases for Apocrine Adenoma:

Name: Apocrine Adenoma 12 15 73
Tubular Apocrine Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3895
NCIt 50 C27527 C4168
SNOMED-CT 68 307596009 36318001
UMLS 73 C0334345

Summaries for Apocrine Adenoma

MalaCards based summary : Apocrine Adenoma, also known as tubular apocrine adenoma, is related to syringocystadenoma papilliferum and schimmelpenning-feuerstein-mims syndrome. An important gene associated with Apocrine Adenoma is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), and among its related pathways/superpathways are HIV Life Cycle and Response to elevated platelet cytosolic Ca2+. Affiliated tissues include skin and breast, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Apocrine Adenoma

Diseases related to Apocrine Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 syringocystadenoma papilliferum 31.0 KRAS MUC1
2 schimmelpenning-feuerstein-mims syndrome 29.9 HRAS KRAS
3 nevus, epidermal 29.3 HRAS KRAS PIK3CA
4 adenocarcinoma 28.7 HRAS KRAS MUC1 PIK3CA
5 squamous cell carcinoma 28.4 HRAS KRAS MUC1 PIK3CA
6 breast apocrine adenoma 12.1
7 eccrine papillary adenoma 11.4
8 hidrocystoma 11.4
9 adenoma 10.6
10 hidradenoma 10.4 MUC1 PIK3CA
11 rare adenocarcinoma of the breast 10.4 KRAS PIK3CA
12 malignant spiradenoma 10.4 CEACAM5 PIK3CA
13 undifferentiated pleomorphic sarcoma 10.3 KRAS PIK3CA
14 breast mucoepidermoid carcinoma 10.3 CEACAM5 MUC1
15 breast adenomyoepithelioma 10.3 CEACAM5 PIK3CA
16 breast myoepithelial neoplasm 10.3 CEACAM5 PIK3CA
17 bile duct mucoepidermoid carcinoma 10.3 CEACAM5 MUC1
18 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.3 KRAS PIK3CA
19 nodular hidradenoma 10.3 CEACAM5 MUC1
20 bile duct cystadenocarcinoma 10.3 CEACAM5 MUC1
21 mucinous ovarian cystadenoma 10.3 CEACAM5 MUC1
22 villous adenoma 10.3 KRAS MUC1
23 appendix cancer 10.3 KRAS MUC1
24 prostate adenoid cystic carcinoma 10.3 HRAS PIK3CA
25 chondroid chordoma 10.3 CEACAM5 MUC1
26 ethmoid sinus cancer 10.3 HRAS PIK3CA
27 ethmoid sinus adenocarcinoma 10.2 HRAS PIK3CA
28 pseudomyxoma peritonei 10.2 KRAS MUC1
29 colonic benign neoplasm 10.2 CEACAM5 KRAS
30 ovarian clear cell carcinoma 10.2 KRAS PIK3CA
31 mixed ductal-endocrine carcinoma 10.2 CEACAM5 MUC1
32 mucinous adenocarcinoma 10.2 KRAS MUC1
33 pancreatic cystadenocarcinoma 10.2 CEACAM5 KRAS
34 papillary adenocarcinoma 10.2 CEACAM5 MUC1
35 small intestinal adenocarcinoma 10.2 KRAS MUC1
36 periampullary adenoma 10.1 HRAS KRAS
37 paronychia 10.1 HRAS KRAS
38 bile duct cysts 10.1 HRAS KRAS
39 secondary hypertrophic osteoarthropathy 10.1 HRAS KRAS
40 nasal cavity adenocarcinoma 10.1 HRAS KRAS
41 anal canal adenocarcinoma 10.1 HRAS KRAS
42 adenosquamous carcinoma 10.1 KRAS MUC1
43 mixed cell type cancer 10.1 HRAS KRAS
44 adenosquamous pancreas carcinoma 10.1 HRAS KRAS
45 serous cystadenocarcinoma 10.0 HRAS PIK3CA
46 core binding factor acute myeloid leukemia 10.0 HRAS KRAS
47 liver angiosarcoma 10.0 HRAS KRAS
48 lacrimal gland adenocarcinoma 10.0 HRAS KRAS
49 cecum adenocarcinoma 10.0 HRAS KRAS
50 pulmonic stenosis 10.0 HRAS KRAS

Graphical network of the top 20 diseases related to Apocrine Adenoma:



Diseases related to Apocrine Adenoma

Symptoms & Phenotypes for Apocrine Adenoma

GenomeRNAi Phenotypes related to Apocrine Adenoma according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 10 KRAS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 10 KRAS
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 10 KRAS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 10 KRAS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 10 PIK3CA UBC KRAS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 10 KRAS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 10 KRAS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 10 KRAS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 10 PIK3CA KRAS
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 10 PIK3CA
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 10 KRAS
12 Decreased viability GR00055-A-2 9.93 HRAS PIK3CA KRAS MUC1
13 Decreased viability GR00106-A-0 9.93 KRAS
14 Decreased viability GR00221-A-1 9.93 HRAS PIK3CA KRAS
15 Decreased viability GR00221-A-2 9.93 HRAS PIK3CA KRAS
16 Decreased viability GR00221-A-3 9.93 HRAS
17 Decreased viability GR00221-A-4 9.93 PIK3CA
18 Decreased viability GR00301-A 9.93 KRAS
19 Decreased viability GR00381-A-1 9.93 KRAS
20 Decreased viability GR00402-S-2 9.93 MUC1 HRAS PIK3CA KRAS
21 Decreased cell migration GR00055-A-1 9.56 MUC1 HRAS PIK3CA KRAS
22 Increased cell migration GR00055-A-3 8.8 HRAS PIK3CA KRAS

Drugs & Therapeutics for Apocrine Adenoma

Search Clinical Trials , NIH Clinical Center for Apocrine Adenoma

Genetic Tests for Apocrine Adenoma

Anatomical Context for Apocrine Adenoma

MalaCards organs/tissues related to Apocrine Adenoma:

41
Skin, Breast

Publications for Apocrine Adenoma

Articles related to Apocrine Adenoma:

(show all 43)
# Title Authors Year
1
Tubular apocrine adenoma: A rare and controversial tumor. ( 29863779 )
2018
2
BRAF and KRAS mutations in tubular apocrine adenoma and papillary eccrine adenoma of the skin. ( 29241739 )
2017
3
Syringocystadenoma papilliferum combined with a tubular apocrine adenoma. ( 29166517 )
2017
4
Tubular Apocrine Adenoma in Association with an Apocrine Hidrocystoma. ( 27772650 )
2016
5
Tubular apocrine adenoma clinically and dermoscopically mimicking basal cell carcinoma. ( 25037809 )
2014
6
Case of tubular apocrine adenoma with follicular differentiation located on the trunk. ( 21906134 )
2012
7
Tubular apocrine adenoma of the nose. ( 21252032 )
2011
8
Lipomatous apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. ( 21854651 )
2011
9
Syringocystadenoma papilliferum of the back combined with a tubular apocrine adenoma. ( 22148038 )
2011
10
Syringocystadenoma Papilliferum in Co-existence with Tubular Apocrine Adenoma on the Calf. ( 22148043 )
2011
11
Squamous cell carcinoma, syringocystadenoma papilliferum and apocrine adenoma arising in a nevus sebaceus of Jadassohn. ( 21393932 )
2011
12
A Case of Tubular Apocrine Adenoma with Syringocystadenoma Papilliferum that Developed in a Nevus Sebaceus. ( 20711270 )
2010
13
Tubular apocrine adenoma: presentation in the vaginal introitus of an eight-year-old. ( 20537077 )
2010
14
Apocrine adenocarcinoma of the right eyelid and apocrine adenoma of the left maxillary sinus. ( 18982051 )
2008
15
Apocrine adenoma of the breast. ( 18491794 )
2008
16
Naevus sebaceus on the female breast accompanied with a tubular apocrine adenoma and a syringocystadenoma papilliferum. ( 17535243 )
2007
17
Axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia. ( 17868540 )
2007
18
Apocrine adenoma of the breast coexistent with invasive carcinoma. ( 17936522 )
2007
19
Mohs micrographic surgery for tubular apocrine adenoma. ( 17076735 )
2006
20
Tubular apocrine adenoma--an unusual eyelid tumour. ( 15105822 )
2005
21
Perianal apocrine adenocarcinoma arising in a benign apocrine adenoma; first case report and review of the literature. ( 15677547 )
2005
22
Tubular apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. ( 16354370 )
2005
23
Multifocal papillary apocrine adenoma arising in a systematized linear epidermal nevus. ( 15186052 )
2004
24
A case of tubular apocrine adenoma with syringocystadenoma papilliferum arising in nevus sebaceus. ( 15235197 )
2004
25
A case of ductal apocrine carcinoma in the left axilla with tubular apocrine adenoma in the right axilla. ( 12598714 )
2003
26
Three-millimeter apocrine adenoma in a man: a case report and review of the literature. ( 14567753 )
2003
27
Tubular apocrine adenoma in association with syringocystadenoma papilliferum. ( 12639465 )
2003
28
Apocrine adenoma of the breast: diagnosis on large core needle biopsy. ( 11358045 )
2001
29
Spiradenoma associated with apocrine adenoma component. ( 9122033 )
1996
30
Tubular apocrine adenoma with eccrine and apocrine immunophenotypes or papillary tubular adenoma? ( 8599457 )
1995
31
Is tubular apocrine adenoma a distinct clinical entity? ( 8238787 )
1993
32
Tubular apocrine adenoma and papillary eccrine adenoma. Entities or unity? ( 1566975 )
1992
33
Apocrine adenoma of the breast: report of a case with investigation of lectin binding patterns in apocrine breast lesions. ( 2362943 )
1990
34
[Tubular apocrine adenoma. Description of 4 cases]. ( 2214926 )
1990
35
A case of tubular apocrine adenoma with syringocystadenoma papilliferum. ( 2551940 )
1989
36
Apocrine adenoma presenting as gynaecomastia in a 14-year-old boy. ( 3235060 )
1988
37
Tubular apocrine adenoma. ( 3036918 )
1987
38
Apocrine adenoma of the breast. ( 3754126 )
1986
39
Tubular apocrine adenoma with perineural invasion. ( 6490990 )
1984
40
Apocrine adenoma versus pocrine carcinoma. Report of two cases. ( 7364989 )
1980
41
Tubular apocrine adenoma. ( 993400 )
1976
42
An unusual tubular apocrine adenoma. ( 4113017 )
1972
43
Apocrine adenoma of the anus. ( 13141230 )
1954

Variations for Apocrine Adenoma

Expression for Apocrine Adenoma

Search GEO for disease gene expression data for Apocrine Adenoma.

Pathways for Apocrine Adenoma

Pathways related to Apocrine Adenoma according to GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.51 HRAS KRAS MUC1 PIK3CA UBC
2
Show member pathways
13.13 CEACAM5 HRAS KRAS PIK3CA
3
Show member pathways
13.11 HRAS KRAS MUC1 PIK3CA UBC
4
Show member pathways
12.58 HRAS KRAS PIK3CA
5
Show member pathways
12.57 HRAS KRAS PIK3CA
6
Show member pathways
12.52 HRAS KRAS PIK3CA
7
Show member pathways
12.51 HRAS KRAS PIK3CA UBC
8 12.49 HRAS KRAS PIK3CA
9
Show member pathways
12.46 HRAS KRAS PIK3CA
10
Show member pathways
12.45 HRAS KRAS PIK3CA
11
Show member pathways
12.44 HRAS KRAS PIK3CA
12
Show member pathways
12.39 HRAS KRAS PIK3CA
13 12.38 HRAS KRAS PIK3CA
14
Show member pathways
12.37 HRAS KRAS PIK3CA
15
Show member pathways
12.35 HRAS KRAS PIK3CA
16
Show member pathways
12.35 HRAS KRAS PIK3CA
17
Show member pathways
12.32 HRAS KRAS PIK3CA
18
Show member pathways
12.32 HRAS KRAS PIK3CA UBC
19
Show member pathways
12.31 HRAS KRAS MUC1 PIK3CA
20
Show member pathways
12.3 HRAS KRAS PIK3CA
21 12.3 HRAS KRAS PIK3CA
22
Show member pathways
12.29 HRAS KRAS PIK3CA
23
Show member pathways
12.27 HRAS KRAS PIK3CA
24
Show member pathways
12.27 HRAS KRAS PIK3CA
25
Show member pathways
12.25 HRAS KRAS PIK3CA
26
Show member pathways
12.2 HRAS KRAS PIK3CA
27
Show member pathways
12.17 HRAS KRAS PIK3CA UBC
28 12.16 HRAS KRAS PIK3CA
29 12.16 HRAS KRAS PIK3CA
30
Show member pathways
12.15 HRAS KRAS MUC1 UBC
31 12.09 HRAS KRAS PIK3CA
32
Show member pathways
12.08 HRAS KRAS PIK3CA
33
Show member pathways
12.05 HRAS KRAS PIK3CA
34
Show member pathways
12.05 HRAS KRAS PIK3CA UBC
35 12.04 HRAS KRAS PIK3CA
36 12.03 HRAS KRAS PIK3CA
37
Show member pathways
12.03 HRAS KRAS PIK3CA
38
Show member pathways
12.01 HRAS KRAS PIK3CA
39
Show member pathways
12.01 HRAS KRAS PIK3CA
40
Show member pathways
11.99 HRAS KRAS PIK3CA UBC
41 11.96 HRAS KRAS PIK3CA
42
Show member pathways
11.95 HRAS KRAS PIK3CA
43
Show member pathways
11.94 HRAS KRAS PIK3CA
44
Show member pathways
11.93 HRAS KRAS PIK3CA
45 11.92 HRAS KRAS PIK3CA
46
Show member pathways
11.91 HRAS KRAS UBC
47
Show member pathways
11.91 HRAS KRAS PIK3CA UBC
48 11.89 HRAS KRAS PIK3CA
49
Show member pathways
11.86 HRAS KRAS PIK3CA
50 11.84 HRAS KRAS PIK3CA

GO Terms for Apocrine Adenoma

Cellular components related to Apocrine Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.1 CEACAM5 HRAS KRAS MUC1 PIK3CA UBC

Biological processes related to Apocrine Adenoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.7 HRAS KRAS UBC
2 axon guidance GO:0007411 9.67 HRAS KRAS PIK3CA
3 cytokine-mediated signaling pathway GO:0019221 9.67 KRAS MUC1 PIK3CA UBC
4 T cell receptor signaling pathway GO:0050852 9.65 HRAS PIK3CA UBC
5 negative regulation of neuron apoptotic process GO:0043524 9.61 HRAS KRAS PIK3CA
6 leukocyte migration GO:0050900 9.56 CEACAM5 HRAS KRAS PIK3CA
7 positive regulation of MAP kinase activity GO:0043406 9.55 HRAS KRAS
8 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.54 MUC1 UBC
9 regulation of long-term neuronal synaptic plasticity GO:0048169 9.51 HRAS KRAS
10 epidermal growth factor receptor signaling pathway GO:0007173 9.5 HRAS KRAS PIK3CA
11 negative regulation of anoikis GO:2000811 9.46 CEACAM5 PIK3CA
12 Fc-epsilon receptor signaling pathway GO:0038095 9.46 HRAS KRAS PIK3CA UBC
13 response to isolation stress GO:0035900 9.4 HRAS KRAS
14 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.26 HRAS KRAS MUC1 UBC
15 ERBB2 signaling pathway GO:0038128 8.92 HRAS KRAS PIK3CA UBC

Molecular functions related to Apocrine Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GDP binding GO:0019003 8.62 HRAS KRAS

Sources for Apocrine Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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