MCID: APC003
MIFTS: 37

Apocrine Adenoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Apocrine Adenoma

MalaCards integrated aliases for Apocrine Adenoma:

Name: Apocrine Adenoma 12 15 73
Tubular Apocrine Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3895
NCIt 50 C27527 C4168
SNOMED-CT 68 36318001
UMLS 73 C0334345

Summaries for Apocrine Adenoma

MalaCards based summary : Apocrine Adenoma, also known as tubular apocrine adenoma, is related to syringocystadenoma papilliferum and schimmelpenning-feuerstein-mims syndrome. An important gene associated with Apocrine Adenoma is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), and among its related pathways/superpathways are HIV Life Cycle and Response to elevated platelet cytosolic Ca2+. Affiliated tissues include skin, breast and lung, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Apocrine Adenoma

Diseases related to Apocrine Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 syringocystadenoma papilliferum 30.9 KRAS MUC1
2 schimmelpenning-feuerstein-mims syndrome 30.0 HRAS KRAS
3 squamous cell carcinoma 29.8 HRAS MUC1 PIK3CA
4 nevus, epidermal 29.8 HRAS KRAS PIK3CA
5 adenocarcinoma 29.8 HRAS KRAS MUC1 PIK3CA
6 breast apocrine adenoma 12.2
7 eccrine papillary adenoma 11.5
8 hidrocystoma 11.5
9 adenoma 10.8
10 hidradenoma 10.1 MUC1 PIK3CA
11 papillary adenocarcinoma 10.1 CEACAM5 MUC1
12 rare adenocarcinoma of the breast 10.1 KRAS PIK3CA
13 malignant spiradenoma 10.1 CEACAM5 PIK3CA
14 breast mucoepidermoid carcinoma 10.1 CEACAM5 MUC1
15 breast adenomyoepithelioma 10.1 CEACAM5 PIK3CA
16 bile duct mucoepidermoid carcinoma 10.1 CEACAM5 MUC1
17 breast myoepithelial neoplasm 10.1 CEACAM5 PIK3CA
18 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.1 KRAS PIK3CA
19 nodular hidradenoma 10.1 CEACAM5 MUC1
20 apocrine adenocarcinoma 10.1
21 bile duct cystadenocarcinoma 10.1 CEACAM5 MUC1
22 undifferentiated pleomorphic sarcoma 10.1 KRAS PIK3CA
23 prostate adenoid cystic carcinoma 10.1 HRAS PIK3CA
24 mucinous ovarian cystadenoma 10.1 CEACAM5 MUC1
25 urachal adenocarcinoma 10.1 CEACAM5 KRAS
26 villous adenoma 10.1 KRAS MUC1
27 ethmoid sinus cancer 10.1 HRAS PIK3CA
28 duodenal disease 10.1 KRAS MUC1
29 ethmoid sinus adenocarcinoma 10.1 HRAS PIK3CA
30 pancreatic cystadenocarcinoma 10.1 CEACAM5 KRAS
31 chondroid chordoma 10.1 CEACAM5 MUC1
32 angiosarcoma 10.1 KRAS MUC1
33 colonic benign neoplasm 10.1 CEACAM5 KRAS
34 pseudomyxoma peritonei 10.1 KRAS MUC1
35 mixed ductal-endocrine carcinoma 10.1 CEACAM5 MUC1
36 ovarian clear cell carcinoma 10.1 KRAS PIK3CA
37 mucinous adenocarcinoma 10.1 KRAS MUC1
38 periampullary adenoma 10.0 HRAS KRAS
39 paronychia 10.0 HRAS KRAS
40 bile duct cysts 10.0 HRAS KRAS
41 appendix disease 10.0 HRAS KRAS
42 nasal cavity adenocarcinoma 10.0 HRAS KRAS
43 secondary hypertrophic osteoarthropathy 10.0 HRAS KRAS
44 skin squamous cell carcinoma 10.0 HRAS PIK3CA
45 anal canal adenocarcinoma 10.0 HRAS KRAS
46 fetal adenoma 10.0 CEACAM5 HRAS
47 prostate squamous cell carcinoma 10.0 CEACAM5 HRAS
48 ovarian cystadenocarcinoma 10.0 HRAS KRAS
49 core binding factor acute myeloid leukemia 10.0 HRAS KRAS
50 mucinous lung adenocarcinoma 10.0 HRAS KRAS

Graphical network of the top 20 diseases related to Apocrine Adenoma:



Diseases related to Apocrine Adenoma

Symptoms & Phenotypes for Apocrine Adenoma

GenomeRNAi Phenotypes related to Apocrine Adenoma according to GeneCards Suite gene sharing:

26 (show all 23)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.21 HRAS KRAS PIK3CA MUC1
2 Decreased viability GR00106-A-0 10.21 KRAS
3 Decreased viability GR00221-A-1 10.21 HRAS KRAS PIK3CA
4 Decreased viability GR00221-A-2 10.21 HRAS KRAS PIK3CA
5 Decreased viability GR00221-A-3 10.21 HRAS
6 Decreased viability GR00221-A-4 10.21 PIK3CA
7 Decreased viability GR00301-A 10.21 KRAS
8 Decreased viability GR00381-A-1 10.21 KRAS
9 Decreased viability GR00402-S-2 10.21 HRAS KRAS PIK3CA MUC1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 10.03 PIK3CA
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 10.03 KRAS
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 10.03 KRAS
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 10.03 KRAS
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 10.03 KRAS
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 10.03 KRAS PIK3CA UBC
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 10.03 KRAS
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 10.03 KRAS
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 10.03 KRAS
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 10.03 KRAS PIK3CA
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 10.03 PIK3CA
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 10.03 KRAS
22 Decreased cell migration GR00055-A-1 9.56 HRAS KRAS MUC1 PIK3CA
23 Increased cell migration GR00055-A-3 8.8 HRAS KRAS PIK3CA

Drugs & Therapeutics for Apocrine Adenoma

Search Clinical Trials , NIH Clinical Center for Apocrine Adenoma

Genetic Tests for Apocrine Adenoma

Anatomical Context for Apocrine Adenoma

MalaCards organs/tissues related to Apocrine Adenoma:

41
Skin, Breast, Lung, Liver, Colon, Pancreas, Thyroid

Publications for Apocrine Adenoma

Articles related to Apocrine Adenoma:

(show all 47)
# Title Authors Year
1
Tubular apocrine adenoma: A rare and controversial tumor. ( 29863779 )
2018
2
Blaschkoid distribution of composite syringocystadenoma papilliferum and tubular apocrine adenoma without naevus sebaceous. ( 30251370 )
2018
3
Tubular Apocrine Adenoma on Vulva: An Unusual Location. ( 30258809 )
2018
4
Ectopic Tubular Papillary Apocrine Adenoma on the Eyelid: A Case Report of Misleading Clinical Presentation and Location. ( 30320096 )
2018
5
BRAF and KRAS mutations in tubular apocrine adenoma and papillary eccrine adenoma of the skin. ( 29241739 )
2017
6
Syringocystadenoma papilliferum combined with a tubular apocrine adenoma. ( 29166517 )
2017
7
Tubular Apocrine Adenoma in Association with an Apocrine Hidrocystoma. ( 27772650 )
2016
8
Tubular apocrine adenoma clinically and dermoscopically mimicking basal cell carcinoma. ( 25037809 )
2014
9
Case of tubular apocrine adenoma with follicular differentiation located on the trunk. ( 21906134 )
2012
10
Tubular apocrine adenoma of the nose. ( 21252032 )
2011
11
Lipomatous apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. ( 21854651 )
2011
12
Syringocystadenoma papilliferum of the back combined with a tubular apocrine adenoma. ( 22148038 )
2011
13
Syringocystadenoma Papilliferum in Co-existence with Tubular Apocrine Adenoma on the Calf. ( 22148043 )
2011
14
Squamous cell carcinoma, syringocystadenoma papilliferum and apocrine adenoma arising in a nevus sebaceus of Jadassohn. ( 21393932 )
2011
15
Tubular apocrine adenoma: presentation in the vaginal introitus of an eight-year-old. ( 20537077 )
2010
16
A Case of Tubular Apocrine Adenoma with Syringocystadenoma Papilliferum that Developed in a Nevus Sebaceus. ( 20711270 )
2010
17
Apocrine adenocarcinoma of the right eyelid and apocrine adenoma of the left maxillary sinus. ( 18982051 )
2008
18
Apocrine adenoma of the breast. ( 18491794 )
2008
19
Naevus sebaceus on the female breast accompanied with a tubular apocrine adenoma and a syringocystadenoma papilliferum. ( 17535243 )
2007
20
Axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia. ( 17868540 )
2007
21
Apocrine adenoma of the breast coexistent with invasive carcinoma. ( 17936522 )
2007
22
Mohs micrographic surgery for tubular apocrine adenoma. ( 17076735 )
2006
23
Tubular apocrine adenoma--an unusual eyelid tumour. ( 15105822 )
2005
24
Perianal apocrine adenocarcinoma arising in a benign apocrine adenoma; first case report and review of the literature. ( 15677547 )
2005
25
Tubular apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. ( 16354370 )
2005
26
Multifocal papillary apocrine adenoma arising in a systematized linear epidermal nevus. ( 15186052 )
2004
27
A case of tubular apocrine adenoma with syringocystadenoma papilliferum arising in nevus sebaceus. ( 15235197 )
2004
28
A case of ductal apocrine carcinoma in the left axilla with tubular apocrine adenoma in the right axilla. ( 12598714 )
2003
29
Three-millimeter apocrine adenoma in a man: a case report and review of the literature. ( 14567753 )
2003
30
Tubular apocrine adenoma in association with syringocystadenoma papilliferum. ( 12639465 )
2003
31
Apocrine adenoma of the breast: diagnosis on large core needle biopsy. ( 11358045 )
2001
32
Spiradenoma associated with apocrine adenoma component. ( 9122033 )
1996
33
Tubular apocrine adenoma with eccrine and apocrine immunophenotypes or papillary tubular adenoma? ( 8599457 )
1995
34
Is tubular apocrine adenoma a distinct clinical entity? ( 8238787 )
1993
35
Tubular apocrine adenoma and papillary eccrine adenoma. Entities or unity? ( 1566975 )
1992
36
Apocrine adenoma of the breast: report of a case with investigation of lectin binding patterns in apocrine breast lesions. ( 2362943 )
1990
37
[Tubular apocrine adenoma. Description of 4 cases]. ( 2214926 )
1990
38
A case of tubular apocrine adenoma with syringocystadenoma papilliferum. ( 2551940 )
1989
39
Apocrine adenoma presenting as gynaecomastia in a 14-year-old boy. ( 3235060 )
1988
40
Tubular apocrine adenoma. ( 3036918 )
1987
41
Apocrine adenoma of the breast. ( 3754126 )
1986
42
Tubular apocrine adenoma with perineural invasion. ( 6490990 )
1984
43
Apocrine adenoma versus pocrine carcinoma. Report of two cases. ( 7364989 )
1980
44
Tubular apocrine adenoma. ( 993400 )
1976
45
Tubular apocrine adenoma. ( 4345346 )
1973
46
An unusual tubular apocrine adenoma. ( 4113017 )
1972
47
Apocrine adenoma of the anus. ( 13141230 )
1954

Variations for Apocrine Adenoma

Expression for Apocrine Adenoma

Search GEO for disease gene expression data for Apocrine Adenoma.

Pathways for Apocrine Adenoma

Pathways related to Apocrine Adenoma according to GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.51 HRAS KRAS MUC1 PIK3CA UBC
2
Show member pathways
13.14 CEACAM5 HRAS KRAS PIK3CA
3
Show member pathways
13.09 HRAS KRAS MUC1 PIK3CA UBC
4
Show member pathways
12.67 HRAS KRAS PIK3CA
5
Show member pathways
12.62 HRAS KRAS PIK3CA
6
Show member pathways
12.62 HRAS KRAS PIK3CA
7
Show member pathways
12.59 HRAS KRAS PIK3CA
8
Show member pathways
12.57 HRAS KRAS PIK3CA
9
Show member pathways
12.53 HRAS KRAS PIK3CA
10
Show member pathways
12.51 HRAS KRAS PIK3CA UBC
11 12.5 HRAS KRAS PIK3CA
12
Show member pathways
12.49 HRAS PIK3CA UBC
13
Show member pathways
12.47 HRAS PIK3CA UBC
14
Show member pathways
12.46 HRAS KRAS PIK3CA
15
Show member pathways
12.46 HRAS KRAS PIK3CA
16
Show member pathways
12.39 HRAS KRAS PIK3CA
17 12.39 HRAS KRAS PIK3CA
18
Show member pathways
12.37 HRAS KRAS PIK3CA
19
Show member pathways
12.36 HRAS KRAS PIK3CA
20
Show member pathways
12.35 HRAS KRAS PIK3CA
21
Show member pathways
12.35 HRAS KRAS PIK3CA UBC
22
Show member pathways
12.32 HRAS KRAS PIK3CA
23
Show member pathways
12.3 HRAS KRAS PIK3CA
24 12.3 HRAS KRAS PIK3CA
25
Show member pathways
12.3 HRAS KRAS MUC1 PIK3CA
26
Show member pathways
12.29 HRAS KRAS PIK3CA
27
Show member pathways
12.28 HRAS KRAS PIK3CA
28
Show member pathways
12.27 HRAS KRAS PIK3CA
29
Show member pathways
12.27 HRAS KRAS PIK3CA
30
Show member pathways
12.25 HRAS KRAS PIK3CA
31
Show member pathways
12.25 HRAS KRAS PIK3CA
32
Show member pathways
12.2 HRAS KRAS PIK3CA
33
Show member pathways
12.18 HRAS PIK3CA UBC
34 12.17 HRAS KRAS PIK3CA
35
Show member pathways
12.17 HRAS KRAS PIK3CA UBC
36 12.16 HRAS KRAS PIK3CA
37
Show member pathways
12.15 HRAS KRAS MUC1 UBC
38 12.09 HRAS KRAS PIK3CA
39
Show member pathways
12.08 HRAS KRAS PIK3CA
40
Show member pathways
12.08 HRAS KRAS PIK3CA
41
Show member pathways
12.06 HRAS KRAS PIK3CA
42
Show member pathways
12.05 HRAS KRAS PIK3CA UBC
43 12.04 HRAS KRAS PIK3CA
44
Show member pathways
12.04 HRAS KRAS PIK3CA
45
Show member pathways
12.03 HRAS KRAS PIK3CA
46 12.01 HRAS KRAS PIK3CA
47
Show member pathways
12.01 HRAS KRAS PIK3CA
48
Show member pathways
12 HRAS KRAS PIK3CA
49
Show member pathways
11.99 HRAS KRAS PIK3CA UBC
50 11.96 HRAS KRAS PIK3CA

GO Terms for Apocrine Adenoma

Cellular components related to Apocrine Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.1 CEACAM5 HRAS KRAS MUC1 PIK3CA UBC

Biological processes related to Apocrine Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras protein signal transduction GO:0007265 9.43 HRAS KRAS
2 negative regulation of neuron apoptotic process GO:0043524 9.43 HRAS KRAS PIK3CA
3 positive regulation of MAP kinase activity GO:0043406 9.4 HRAS KRAS
4 regulation of long-term neuronal synaptic plasticity GO:0048169 9.37 HRAS KRAS
5 negative regulation of anoikis GO:2000811 9.32 CEACAM5 PIK3CA
6 response to isolation stress GO:0035900 9.16 HRAS KRAS
7 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.13 HRAS KRAS MUC1
8 cytokine-mediated signaling pathway GO:0019221 8.92 KRAS MUC1 PIK3CA UBC

Molecular functions related to Apocrine Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GDP binding GO:0019003 8.62 HRAS KRAS

Sources for Apocrine Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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