MCID: APC003
MIFTS: 34

Apocrine Adenoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Apocrine Adenoma

MalaCards integrated aliases for Apocrine Adenoma:

Name: Apocrine Adenoma 12 15 72
Tubular Apocrine Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3895
NCIt 50 C27527 C4168
SNOMED-CT 68 36318001
UMLS 72 C0334345

Summaries for Apocrine Adenoma

MalaCards based summary : Apocrine Adenoma, also known as tubular apocrine adenoma, is related to hidrocystoma and syringocystadenoma papilliferum. An important gene associated with Apocrine Adenoma is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are HIV Life Cycle and Developmental Biology. Affiliated tissues include skin and breast, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Apocrine Adenoma

Diseases related to Apocrine Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
# Related Disease Score Top Affiliating Genes
1 hidrocystoma 33.3 SOX10 KRT8
2 syringocystadenoma papilliferum 31.5 MUC1 KRAS
3 hidradenoma 30.9 PIK3CA MUC1
4 schimmelpenning-feuerstein-mims syndrome 30.5 KRAS HRAS
5 mammary paget's disease 30.1 MUC1 KRT8
6 nevus, epidermal 30.0 PIK3CA KRAS HRAS
7 squamous cell carcinoma 29.4 PIK3CA MUC1 HRAS BRAF
8 adenocarcinoma 29.2 PIK3CA MUC1 KRAS HRAS BRAF
9 breast cancer 27.6 PIK3CA MUC1 KRT8 KRAS HRAS CEACAM5
10 breast apocrine adenoma 12.4
11 adenoma 10.8
12 hyperplastic polyposis syndrome 10.6 KRAS BRAF
13 neurenteric cyst 10.6 KRT8 KRAS
14 mature teratoma 10.5 KRAS BRAF
15 rare adenocarcinoma of the breast 10.5 PIK3CA KRAS
16 apocrine sweat gland neoplasm 10.5 SOX10 KRT8
17 papillary tumor of the pineal region 10.4 MUC1 BRAF
18 erdheim-chester disease 10.4 PIK3CA BRAF
19 pilomyxoid astrocytoma 10.4 KRAS BRAF
20 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.4 PIK3CA KRAS
21 paronychia 10.4 KRAS HRAS
22 adenofibroma 10.4 MUC1 BRAF
23 periampullary adenoma 10.4 KRAS HRAS
24 apocrine adenocarcinoma 10.4
25 undifferentiated pleomorphic sarcoma 10.4 PIK3CA KRAS
26 pancreatic cystadenocarcinoma 10.4 KRAS CEACAM5
27 breast secretory carcinoma 10.4 SOX10 KRT8
28 spitz nevus 10.4 HRAS BRAF
29 bile duct cysts 10.4 KRAS HRAS
30 appendix disease 10.4 KRAS HRAS
31 nasal cavity adenocarcinoma 10.4 KRAS HRAS
32 anal canal adenocarcinoma 10.3 KRAS HRAS
33 secondary hypertrophic osteoarthropathy 10.3 KRAS HRAS
34 malignant conjunctival melanoma 10.3 SOX10 HRAS
35 pleomorphic liposarcoma 10.3 MUC1 KRT8
36 papillary adenocarcinoma 10.3 MUC1 CEACAM5
37 ovarian cystadenocarcinoma 10.3 KRAS HRAS
38 cutaneous adenocystic carcinoma 10.3 KRT8 CEACAM5
39 mucinous tubular and spindle renal cell carcinoma 10.3 MUC1 KRT8
40 pilocytic astrocytoma 10.3 SOX10 KRAS BRAF
41 malignant spiradenoma 10.3 PIK3CA CEACAM5
42 prostate adenoid cystic carcinoma 10.3 PIK3CA HRAS
43 pregnancy adenoma 10.3 PIK3CA KRT8
44 lymphoepithelioma-like carcinoma 10.3 MUC1 KRT8
45 ethmoid sinus adenocarcinoma 10.3 PIK3CA HRAS
46 eccrine papillary adenoma 10.3
47 ethmoid sinus cancer 10.3 PIK3CA HRAS
48 breast mucoepidermoid carcinoma 10.3 MUC1 CEACAM5
49 core binding factor acute myeloid leukemia 10.3 KRAS HRAS
50 bile duct mucoepidermoid carcinoma 10.2 MUC1 CEACAM5

Graphical network of the top 20 diseases related to Apocrine Adenoma:



Diseases related to Apocrine Adenoma

Symptoms & Phenotypes for Apocrine Adenoma

GenomeRNAi Phenotypes related to Apocrine Adenoma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.03 BRAF HRAS KRAS MUC1 PIK3CA
2 Decreased viability GR00106-A-0 10.03 KRAS
3 Decreased viability GR00221-A-1 10.03 HRAS KRAS PIK3CA
4 Decreased viability GR00221-A-2 10.03 HRAS KRAS PIK3CA
5 Decreased viability GR00221-A-3 10.03 HRAS
6 Decreased viability GR00221-A-4 10.03 BRAF PIK3CA
7 Decreased viability GR00301-A 10.03 BRAF KRAS
8 Decreased viability GR00381-A-1 10.03 BRAF KRAS
9 Decreased viability GR00402-S-2 10.03 BRAF HRAS KRAS MUC1 PIK3CA
10 Decreased cell migration GR00055-A-1 9.55 BRAF HRAS KRAS MUC1 PIK3CA
11 Increased cell migration GR00055-A-3 8.92 BRAF HRAS KRAS PIK3CA

MGI Mouse Phenotypes related to Apocrine Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.63 BRAF HRAS KRAS KRT8 SLC4A9 SOX10
2 embryo MP:0005380 9.43 BRAF KRAS KRT8 PIK3CA SOX10 UBC
3 neoplasm MP:0002006 9.02 BRAF HRAS KRAS PIK3CA SOX10

Drugs & Therapeutics for Apocrine Adenoma

Search Clinical Trials , NIH Clinical Center for Apocrine Adenoma

Genetic Tests for Apocrine Adenoma

Anatomical Context for Apocrine Adenoma

MalaCards organs/tissues related to Apocrine Adenoma:

41
Skin, Breast

Publications for Apocrine Adenoma

Articles related to Apocrine Adenoma:

(show top 50) (show all 76)
# Title Authors PMID Year
1
Tubular apocrine adenoma: dermoscopic and in vivo reflectance confocal microscopic aspects. 38
31286506 2019
2
Blaschkoid distribution of composite syringocystadenoma papilliferum and tubular apocrine adenoma without naevus sebaceous. 38
30251370 2019
3
Tubular apocrine adenoma: A rare and controversial tumor. 38
29863779 2019
4
Apocrine Adenoma of the External Auditory Canal with Pseudoepitheliomatous Hyperplasia. 38
30915250 2019
5
Tubular Apocrine Adenoma on Vulva: An Unusual Location. 38
30258809 2018
6
Ectopic Tubular Papillary Apocrine Adenoma on the Eyelid: A Case Report of Misleading Clinical Presentation and Location. 38
30320096 2018
7
Umbilical Lesions: Clinicopathologic Features of 99 Tumors. 38
29484912 2018
8
BRAF and KRAS mutations in tubular apocrine adenoma and papillary eccrine adenoma of the skin. 38
29241739 2018
9
Syringocystadenoma papilliferum combined with a tubular apocrine adenoma. 38
29166517 2017
10
Tubular Apocrine Adenoma in Association with an Apocrine Hidrocystoma. 38
27772650 2016
11
[Tubulo-papillary apocrine adenoma in association with syringocystadenoma papilliferum]. 38
27693311 2016
12
Tubular apocrine adenoma clinically and dermoscopically mimicking basal cell carcinoma. 38
25037809 2014
13
Development of six tumors in a sebaceus nevus of jadassohn: report of a case. 38
24421851 2013
14
Fatal metastatic cutaneous squamous cell carcinoma evolving from a localized verrucous epidermal nevus. 38
24403890 2013
15
Syringocystadenoma papilliferum in the right lower abdomen: a case report and review of literature. 38
23569386 2013
16
Case of tubular apocrine adenoma with follicular differentiation located on the trunk. 38
21906134 2012
17
Anal apocrine carcinoma: a case report and literature review. 38
22307230 2012
18
Syringocystadenoma papilliferum of the back combined with a tubular apocrine adenoma. 38
22148038 2011
19
Syringocystadenoma Papilliferum in Co-existence with Tubular Apocrine Adenoma on the Calf. 38
22148043 2011
20
A giant ectopic hidradenoma papilliferum in a Niger delta region of Nigeria. 38
22355505 2011
21
Lipomatous apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. 38
21854651 2011
22
Squamous cell carcinoma, syringocystadenoma papilliferum and apocrine adenoma arising in a nevus sebaceus of Jadassohn. 38
21393932 2011
23
Tubular apocrine adenoma of the nose. 38
21252032 2011
24
A Case of Tubular Apocrine Adenoma with Syringocystadenoma Papilliferum that Developed in a Nevus Sebaceus. 38
20711270 2010
25
Tubular apocrine adenoma: presentation in the vaginal introitus of an eight-year-old. 38
20537077 2010
26
Apocrine adenocarcinoma of the right eyelid and apocrine adenoma of the left maxillary sinus. 38
18982051 2008
27
Congenital apocrine tumour: a rare scalp tumour. 38
18629773 2008
28
Apocrine adenoma of the breast. 38
18491794 2008
29
Non-operative breast pathology: apocrine lesions. 38
18042688 2007
30
Naevus sebaceus on the female breast accompanied with a tubular apocrine adenoma and a syringocystadenoma papilliferum. 38
17535243 2007
31
Tubular adenoma and syringocystadenoma papilliferum: a reappraisal of their relationship. An interobserver study of a series, by a panel of dermatopathologists. 38
17519623 2007
32
Apocrine adenoma of the breast coexistent with invasive carcinoma. 38
17936522 2007
33
Axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia. 38
17868540 2007
34
Mohs micrographic surgery for tubular apocrine adenoma. 38
17076735 2006
35
An unusual hamartoma of the folliculosebaceous-apocrine unit: a case report. 38
16640544 2006
36
Tubular adenoma of the skin with follicular and sebaceous differentiation: A report of two cases. 38
16625077 2006
37
Tubular apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. 38
16354370 2005
38
Eyelid reconstruction using a split eyelid flap after excision of a palpebral tumour in a Persian cat. 38
16119058 2005
39
Tubular apocrine adenoma--an unusual eyelid tumour. 38
15105822 2005
40
Perianal apocrine adenocarcinoma arising in a benign apocrine adenoma; first case report and review of the literature. 38
15677547 2005
41
A case of tubular apocrine adenoma with syringocystadenoma papilliferum arising in nevus sebaceus. 38
15235197 2004
42
Multifocal papillary apocrine adenoma arising in a systematized linear epidermal nevus. 38
15186052 2004
43
Three-millimeter apocrine adenoma in a man: a case report and review of the literature. 38
14567753 2003
44
Mixed tubulopapillary hidradenoma and syringocystadenoma papilliferum occurring as a verrucous tumor. 38
12641782 2003
45
Tubular apocrine adenoma in association with syringocystadenoma papilliferum. 38
12639465 2003
46
A case of ductal apocrine carcinoma in the left axilla with tubular apocrine adenoma in the right axilla. 38
12598714 2003
47
Verrucous carcinoma arising within syringocystadenoma papilliferum. 38
12458900 2002
48
Apocrine adenoma of the breast: diagnosis on large core needle biopsy. 38
11358045 2001
49
Spiradenoma associated with apocrine adenoma component. 38
9122033 1996
50
Tubular apocrine adenoma with eccrine and apocrine immunophenotypes or papillary tubular adenoma? 38
8599457 1995

Variations for Apocrine Adenoma

Expression for Apocrine Adenoma

Search GEO for disease gene expression data for Apocrine Adenoma.

Pathways for Apocrine Adenoma

Pathways related to Apocrine Adenoma according to GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.61 UBC PIK3CA MUC1 KRAS HRAS BRAF
2
Show member pathways
13.36 UBC PIK3CA KRT8 KRAS HRAS BRAF
3
Show member pathways
13.21 UBC PIK3CA MUC1 KRAS HRAS BRAF
4
Show member pathways
12.83 PIK3CA KRAS HRAS BRAF
5
Show member pathways
12.82 PIK3CA KRAS HRAS BRAF
6
Show member pathways
12.81 PIK3CA KRAS HRAS BRAF
7
Show member pathways
12.79 PIK3CA KRAS HRAS BRAF
8
Show member pathways
12.79 PIK3CA KRAS HRAS BRAF
9 12.76 PIK3CA KRAS HRAS BRAF
10
Show member pathways
12.73 UBC KRAS HRAS BRAF
11
Show member pathways
12.73 PIK3CA KRAS HRAS BRAF
12
Show member pathways
12.7 PIK3CA KRAS HRAS BRAF
13
Show member pathways
12.68 PIK3CA KRAS HRAS BRAF
14
Show member pathways
12.65 PIK3CA KRAS HRAS BRAF
15
Show member pathways
12.64 UBC PIK3CA KRAS HRAS
16
Show member pathways
12.62 PIK3CA KRAS HRAS BRAF
17
Show member pathways
12.61 PIK3CA KRAS HRAS BRAF
18 12.52 PIK3CA KRAS HRAS BRAF
19
Show member pathways
12.49 PIK3CA KRAS HRAS BRAF
20
Show member pathways
12.42 PIK3CA KRAS HRAS BRAF
21
Show member pathways
12.4 PIK3CA KRAS HRAS BRAF
22
Show member pathways
12.34 UBC PIK3CA KRAS HRAS
23
Show member pathways
12.31 PIK3CA KRAS HRAS BRAF
24
Show member pathways
12.31 UBC PIK3CA KRAS HRAS
25
Show member pathways
12.3 PIK3CA KRAS BRAF
26
Show member pathways
12.3 UBC MUC1 KRAS HRAS
27
Show member pathways
12.28 KRAS HRAS BRAF
28
Show member pathways
12.27 PIK3CA KRAS HRAS
29
Show member pathways
12.26 PIK3CA KRAS HRAS BRAF
30
Show member pathways
12.25 PIK3CA KRAS HRAS BRAF
31
Show member pathways
12.25 UBC PIK3CA KRAS HRAS BRAF
32
Show member pathways
12.24 KRAS HRAS BRAF
33 12.24 PIK3CA KRAS HRAS
34
Show member pathways
12.2 KRAS HRAS BRAF
35 12.18 PIK3CA KRAS HRAS
36
Show member pathways
12.16 PIK3CA KRAS HRAS BRAF
37
Show member pathways
12.16 PIK3CA KRAS HRAS
38
Show member pathways
12.14 PIK3CA KRAS HRAS
39
Show member pathways
12.14 UBC PIK3CA KRAS HRAS
40
Show member pathways
12.13 KRAS HRAS BRAF
41 12.13 PIK3CA KRAS HRAS BRAF
42 12.12 KRAS HRAS BRAF
43 12.11 PIK3CA KRAS HRAS
44
Show member pathways
12.1 PIK3CA KRAS HRAS
45
Show member pathways
12.09 PIK3CA KRAS HRAS BRAF
46 12.08 PIK3CA KRAS HRAS
47
Show member pathways
12.08 KRAS HRAS BRAF
48
Show member pathways
12.08 PIK3CA KRAS HRAS
49
Show member pathways
12.08 PIK3CA KRAS HRAS
50
Show member pathways
12.05 PIK3CA KRAS HRAS CEACAM5

GO Terms for Apocrine Adenoma

Cellular components related to Apocrine Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.23 UBC SLC4A9 PIK3CA MUC1 KRAS HRAS

Biological processes related to Apocrine Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.76 UBC SOX10 CEACAM5 BRAF
2 positive regulation of gene expression GO:0010628 9.67 SOX10 KRAS HRAS BRAF
3 MAPK cascade GO:0000165 9.65 KRAS HRAS BRAF
4 T cell receptor signaling pathway GO:0050852 9.5 PIK3CA HRAS BRAF
5 cytokine-mediated signaling pathway GO:0019221 9.46 UBC PIK3CA MUC1 KRAS
6 regulation of long-term neuronal synaptic plasticity GO:0048169 9.43 KRAS HRAS
7 negative regulation of anoikis GO:2000811 9.4 PIK3CA CEACAM5
8 response to isolation stress GO:0035900 9.26 KRAS HRAS
9 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.13 MUC1 KRAS HRAS
10 negative regulation of neuron apoptotic process GO:0043524 8.92 PIK3CA KRAS HRAS BRAF

Sources for Apocrine Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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