Apocrine Adenoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: APC003 MIFTS: 34	Apocrine Adenoma Categories: Cancer diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Apocrine Adenoma

MalaCards integrated aliases for Apocrine Adenoma:

Name: Apocrine Adenoma ¹² ¹⁵ ⁷²

Tubular Apocrine Adenoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3895

NCIt ⁵⁰ C27527 C4168

SNOMED-CT ⁶⁸ 36318001

UMLS ⁷² C0334345

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Summaries for Apocrine Adenoma

MalaCards based summary : Apocrine Adenoma, also known as tubular apocrine adenoma, is related to hidrocystoma and syringocystadenoma papilliferum. An important gene associated with Apocrine Adenoma is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are HIV Life Cycle and Developmental Biology. Affiliated tissues include skin and breast, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Apocrine Adenoma

Diseases related to Apocrine Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)

#	Related Disease	Score	Top Affiliating Genes
1	hidrocystoma	33.3	SOX10 KRT8
2	syringocystadenoma papilliferum	31.5	MUC1 KRAS
3	hidradenoma	30.9	PIK3CA MUC1
4	schimmelpenning-feuerstein-mims syndrome	30.5	KRAS HRAS
5	mammary paget's disease	30.1	MUC1 KRT8
6	nevus, epidermal	30.0	PIK3CA KRAS HRAS
7	squamous cell carcinoma	29.4	PIK3CA MUC1 HRAS BRAF
8	adenocarcinoma	29.2	PIK3CA MUC1 KRAS HRAS BRAF
9	breast cancer	27.6	PIK3CA MUC1 KRT8 KRAS HRAS CEACAM5
10	breast apocrine adenoma	12.4
11	adenoma	10.8
12	hyperplastic polyposis syndrome	10.6	KRAS BRAF
13	neurenteric cyst	10.6	KRT8 KRAS
14	mature teratoma	10.5	KRAS BRAF
15	rare adenocarcinoma of the breast	10.5	PIK3CA KRAS
16	apocrine sweat gland neoplasm	10.5	SOX10 KRT8
17	papillary tumor of the pineal region	10.4	MUC1 BRAF
18	erdheim-chester disease	10.4	PIK3CA BRAF
19	pilomyxoid astrocytoma	10.4	KRAS BRAF
20	ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3	10.4	PIK3CA KRAS
21	paronychia	10.4	KRAS HRAS
22	adenofibroma	10.4	MUC1 BRAF
23	periampullary adenoma	10.4	KRAS HRAS
24	apocrine adenocarcinoma	10.4
25	undifferentiated pleomorphic sarcoma	10.4	PIK3CA KRAS
26	pancreatic cystadenocarcinoma	10.4	KRAS CEACAM5
27	breast secretory carcinoma	10.4	SOX10 KRT8
28	spitz nevus	10.4	HRAS BRAF
29	bile duct cysts	10.4	KRAS HRAS
30	appendix disease	10.4	KRAS HRAS
31	nasal cavity adenocarcinoma	10.4	KRAS HRAS
32	anal canal adenocarcinoma	10.3	KRAS HRAS
33	secondary hypertrophic osteoarthropathy	10.3	KRAS HRAS
34	malignant conjunctival melanoma	10.3	SOX10 HRAS
35	pleomorphic liposarcoma	10.3	MUC1 KRT8
36	papillary adenocarcinoma	10.3	MUC1 CEACAM5
37	ovarian cystadenocarcinoma	10.3	KRAS HRAS
38	cutaneous adenocystic carcinoma	10.3	KRT8 CEACAM5
39	mucinous tubular and spindle renal cell carcinoma	10.3	MUC1 KRT8
40	pilocytic astrocytoma	10.3	SOX10 KRAS BRAF
41	malignant spiradenoma	10.3	PIK3CA CEACAM5
42	prostate adenoid cystic carcinoma	10.3	PIK3CA HRAS
43	pregnancy adenoma	10.3	PIK3CA KRT8
44	lymphoepithelioma-like carcinoma	10.3	MUC1 KRT8
45	ethmoid sinus adenocarcinoma	10.3	PIK3CA HRAS
46	eccrine papillary adenoma	10.3
47	ethmoid sinus cancer	10.3	PIK3CA HRAS
48	breast mucoepidermoid carcinoma	10.3	MUC1 CEACAM5
49	core binding factor acute myeloid leukemia	10.3	KRAS HRAS
50	bile duct mucoepidermoid carcinoma	10.2	MUC1 CEACAM5

Graphical network of the top 20 diseases related to Apocrine Adenoma:

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Symptoms & Phenotypes for Apocrine Adenoma

GenomeRNAi Phenotypes related to Apocrine Adenoma according to GeneCards Suite gene sharing:

²⁶ (show all 11)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-2	10.03	BRAF HRAS KRAS MUC1 PIK3CA
2	Decreased viability	GR00106-A-0	10.03	KRAS
3	Decreased viability	GR00221-A-1	10.03	HRAS KRAS PIK3CA
4	Decreased viability	GR00221-A-2	10.03	HRAS KRAS PIK3CA
5	Decreased viability	GR00221-A-3	10.03	HRAS
6	Decreased viability	GR00221-A-4	10.03	BRAF PIK3CA
7	Decreased viability	GR00301-A	10.03	BRAF KRAS
8	Decreased viability	GR00381-A-1	10.03	BRAF KRAS
9	Decreased viability	GR00402-S-2	10.03	BRAF HRAS KRAS MUC1 PIK3CA
10	Decreased cell migration	GR00055-A-1	9.55	BRAF HRAS KRAS MUC1 PIK3CA
11	Increased cell migration	GR00055-A-3	8.92	BRAF HRAS KRAS PIK3CA

MGI Mouse Phenotypes related to Apocrine Adenoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.63	BRAF HRAS KRAS KRT8 SLC4A9 SOX10
2	embryo	MP:0005380	9.43	BRAF KRAS KRT8 PIK3CA SOX10 UBC
3	neoplasm	MP:0002006	9.02	BRAF HRAS KRAS PIK3CA SOX10

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Drugs & Therapeutics for Apocrine Adenoma

Search Clinical Trials , NIH Clinical Center for Apocrine Adenoma

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Genetic Tests for Apocrine Adenoma

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Anatomical Context for Apocrine Adenoma

MalaCards organs/tissues related to Apocrine Adenoma:

⁴¹

Skin, Breast

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Publications for Apocrine Adenoma

Articles related to Apocrine Adenoma:

(show top 50) (show all 76)

#	Title	Authors	PMID	Year
1	Tubular apocrine adenoma: dermoscopic and in vivo reflectance confocal microscopic aspects. ³⁸	Lupu M...Ardigo M	31286506	2019
2	Blaschkoid distribution of composite syringocystadenoma papilliferum and tubular apocrine adenoma without naevus sebaceous. ³⁸	Khullar G...Mann KK	30251370	2019
3	Tubular apocrine adenoma: A rare and controversial tumor. ³⁸	Cortes-Pinto C...Casanova Seuma JM	29863779	2019
4	Apocrine Adenoma of the External Auditory Canal with Pseudoepitheliomatous Hyperplasia. ³⁸	Ohki M...Kikuchi S	30915250	2019
5	Tubular Apocrine Adenoma on Vulva: An Unusual Location. ³⁸	Jain S...Malkar BV	30258809	2018
6	Ectopic Tubular Papillary Apocrine Adenoma on the Eyelid: A Case Report of Misleading Clinical Presentation and Location. ³⁸	Abbeel L...Van Ginderdeuren R	30320096	2018
7	Umbilical Lesions: Clinicopathologic Features of 99 Tumors. ³⁸	Yan L...Gattuso P	29484912	2018
8	BRAF and KRAS mutations in tubular apocrine adenoma and papillary eccrine adenoma of the skin. ³⁸	Liau JY...Yuan CT	29241739	2018
9	Syringocystadenoma papilliferum combined with a tubular apocrine adenoma. ³⁸	Leda LDSB...Houly RLS	29166517	2017
10	Tubular Apocrine Adenoma in Association with an Apocrine Hidrocystoma. ³⁸	Raven ML...Lucarelli MJ	27772650	2016
11	[Tubulo-papillary apocrine adenoma in association with syringocystadenoma papilliferum]. ³⁸	Ayadi L...Gouiaa N	27693311	2016
12	Tubular apocrine adenoma clinically and dermoscopically mimicking basal cell carcinoma. ³⁸	Ito T...Shimizu H	25037809	2014
13	Development of six tumors in a sebaceus nevus of jadassohn: report of a case. ³⁸	Gozel S...Yikilkan H	24421851	2013
14	Fatal metastatic cutaneous squamous cell carcinoma evolving from a localized verrucous epidermal nevus. ³⁸	Riad H...Hussain K	24403890	2013
15	Syringocystadenoma papilliferum in the right lower abdomen: a case report and review of literature. ³⁸	Xu D...Jin K	23569386	2013
16	Case of tubular apocrine adenoma with follicular differentiation located on the trunk. ³⁸	Nakagomi D...Shimada S	21906134	2012
17	Anal apocrine carcinoma: a case report and literature review. ³⁸	Hall BJ...Liu T	22307230	2012
18	Syringocystadenoma papilliferum of the back combined with a tubular apocrine adenoma. ³⁸	Lee HJ...Lee JD	22148038	2011
19	Syringocystadenoma Papilliferum in Co-existence with Tubular Apocrine Adenoma on the Calf. ³⁸	Yoon JH...Seo SH	22148043	2011
20	A giant ectopic hidradenoma papilliferum in a Niger delta region of Nigeria. ³⁸	Abudu EK...Obi-Ihesie A	22355505	2011
21	Lipomatous apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. ³⁸	Su TC...Chen ML	21854651	2011
22	Squamous cell carcinoma, syringocystadenoma papilliferum and apocrine adenoma arising in a nevus sebaceus of Jadassohn. ³⁸	Malhotra P...Singh A	21393932	2011
23	Tubular apocrine adenoma of the nose. ³⁸	Mitsuishi T...Kawana S	21252032	2011
24	A Case of Tubular Apocrine Adenoma with Syringocystadenoma Papilliferum that Developed in a Nevus Sebaceus. ³⁸	Kim MS...Son SJ	20711270	2010
25	Tubular apocrine adenoma: presentation in the vaginal introitus of an eight-year-old. ³⁸	Ross I...Shwayder T	20537077	2010
26	Apocrine adenocarcinoma of the right eyelid and apocrine adenoma of the left maxillary sinus. ³⁸	Akcay EK...Gumus M	18982051	2008
27	Congenital apocrine tumour: a rare scalp tumour. ³⁸	Goodden JR...Smith MF	18629773	2008
28	Apocrine adenoma of the breast. ³⁸	Cashell AW	18491794	2008
29	Non-operative breast pathology: apocrine lesions. ³⁸	Wells CA...El-Ayat GA	18042688	2007
30	Naevus sebaceus on the female breast accompanied with a tubular apocrine adenoma and a syringocystadenoma papilliferum. ³⁸	Yamane N...Osawa R	17535243	2007
31	Tubular adenoma and syringocystadenoma papilliferum: a reappraisal of their relationship. An interobserver study of a series, by a panel of dermatopathologists. ³⁸	Kazakov DV...Zelger B	17519623	2007
32	Apocrine adenoma of the breast coexistent with invasive carcinoma. ³⁸	Bezic J...Gunjaca G	17936522	2007
33	Axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia. ³⁸	Bujas T...Tomas D	17868540	2007
34	Mohs micrographic surgery for tubular apocrine adenoma. ³⁸	Martinelli PT...Nelson BR	17076735	2006
35	An unusual hamartoma of the folliculosebaceous-apocrine unit: a case report. ³⁸	Kazakov DV...Michal M	16640544	2006
36	Tubular adenoma of the skin with follicular and sebaceous differentiation: A report of two cases. ³⁸	Kazakov DV...Michal M	16625077	2006
37	Tubular apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. ³⁸	Lee CK...Cho YS	16354370	2005
38	Eyelid reconstruction using a split eyelid flap after excision of a palpebral tumour in a Persian cat. ³⁸	Hagard GM	16119058	2005
39	Tubular apocrine adenoma--an unusual eyelid tumour. ³⁸	Stokes J...Dhillon B	15105822	2005
40	Perianal apocrine adenocarcinoma arising in a benign apocrine adenoma; first case report and review of the literature. ³⁸	MacNeill KN...Ghazarian D	15677547	2005
41	A case of tubular apocrine adenoma with syringocystadenoma papilliferum arising in nevus sebaceus. ³⁸	Ahn BK...Kim YC	15235197	2004
42	Multifocal papillary apocrine adenoma arising in a systematized linear epidermal nevus. ³⁸	Rechdouni A...Vadmal MS	15186052	2004
43	Three-millimeter apocrine adenoma in a man: a case report and review of the literature. ³⁸	Pasquale-Styles MA...Milikowski C	14567753	2003
44	Mixed tubulopapillary hidradenoma and syringocystadenoma papilliferum occurring as a verrucous tumor. ³⁸	Hsu PJ...Huang CJ	12641782	2003
45	Tubular apocrine adenoma in association with syringocystadenoma papilliferum. ³⁸	Aktepe F...Dilek FH	12639465	2003
46	A case of ductal apocrine carcinoma in the left axilla with tubular apocrine adenoma in the right axilla. ³⁸	Amo Y...Kawano N	12598714	2003
47	Verrucous carcinoma arising within syringocystadenoma papilliferum. ³⁸	Monticciolo NL...Morgan MB	12458900	2002
48	Apocrine adenoma of the breast: diagnosis on large core needle biopsy. ³⁸	Lui M...James DT	11358045	2001
49	Spiradenoma associated with apocrine adenoma component. ³⁸	Michal M	9122033	1996
50	Tubular apocrine adenoma with eccrine and apocrine immunophenotypes or papillary tubular adenoma? ³⁸	Tellechea O...Baptista AP	8599457	1995

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Genes for Apocrine Adenoma

Genes related to Apocrine Adenoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	19.95	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	16.75	GeneCards inferred via : Publications (show sections)
3	SOX10	SRY-Box Transcription Factor 10	Protein Coding	14.92	DISEASES inferred ¹⁵
4	KRT8	Keratin 8	Protein Coding	14.51	DISEASES inferred ¹⁵
5	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	14	DISEASES inferred ¹⁵
6	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	13.78	DISEASES inferred ¹⁵
7	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	13.02	DISEASES inferred ¹⁵
8	SLC4A9	Solute Carrier Family 4 Member 9	Protein Coding	6.08	DISEASES inferred ¹⁵
9	UBC	Ubiquitin C	Protein Coding	5.5	DISEASES inferred ¹⁵
10	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	3.33	DISEASES inferred ¹⁵

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Variations for Apocrine Adenoma

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Expression for Apocrine Adenoma

Search GEO for disease gene expression data for Apocrine Adenoma.

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Pathways for Apocrine Adenoma

Pathways related to Apocrine Adenoma according to GeneCards Suite gene sharing:

(show top 50) (show all 92)

#	Super pathways	Score	Top Affiliating Genes
1	HIV Life Cycle ⁶⁶ Show member pathways 2-LTR circle formation ⁶⁶ APOBEC3G mediated resistance to HIV-1 infection ⁶⁶ Assembly Of The HIV Virion ⁶⁶ Binding and entry of HIV virion ⁶⁶ Disease ⁶⁶ Diseases of signal transduction ⁶⁶ Early Phase of HIV Life Cycle ⁶⁶ HIV Infection ⁶⁶ Host Interactions of HIV factors ⁶⁶ Infectious disease ⁶⁶ Integration of provirus ⁶⁶ Late Phase of HIV Life Cycle ⁶⁶	13.61	UBC PIK3CA MUC1 KRAS HRAS BRAF
2	Developmental Biology ⁶⁶ Show member pathways Axon guidance ⁶⁶	13.36	UBC PIK3CA KRT8 KRAS HRAS BRAF
3	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.21	UBC PIK3CA MUC1 KRAS HRAS BRAF
4	Regulation of lipid metabolism Insulin signaling-generic cascades ²² Show member pathways acetyl-CoA biosynthesis from citrate ¹ Butyrate-induced histone acetylation ¹ Cell adhesion PLAU signaling ²² Class IB PI3K non-lipid kinase events ¹ Development CNTF receptor signaling ²² Development Growth hormone signaling via PI3K/AKT and MAPK cascades ²² ErbB2/ErbB3 signaling events ¹ Glucose Homeostasis ¹ Insulin signaling pathway ³⁷ IRS activation ⁶⁶ Signal attenuation ⁶⁶ Transcription Receptor-mediated HIF regulation ²² Translation Regulation of EIF2 activity ²² Translation Regulation of EIF4F activity ²² Translation Insulin regulation of translation ²²	12.83	PIK3CA KRAS HRAS BRAF
5	Focal Adhesion ³⁷ ¹ Show member pathways HGF Pathway ⁶⁴ Integrin-mediated Cell Adhesion ¹	12.82	PIK3CA KRAS HRAS BRAF
6	CCR5 Pathway in Macrophages ⁶⁴ Show member pathways Androgen Signaling ⁶⁴ Chemokine Signaling ⁶⁴ Chemokine signaling pathway ³⁷	12.81	PIK3CA KRAS HRAS BRAF
7	NFAT and Cardiac Hypertrophy ⁶⁴ Show member pathways IGF1R Signaling ⁶⁴ Signaling Involved in Cardiac Hypertrophy ⁶⁴	12.79	PIK3CA KRAS HRAS BRAF
8	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.79	PIK3CA KRAS HRAS BRAF
9	Pathways in cancer ³⁷	12.76	PIK3CA KRAS HRAS BRAF
10	Beta-Adrenergic Signaling ⁶⁴ Show member pathways CDK5 Pathway ⁶⁴ Erythropoietin Pathway ⁶⁴ Insulin Receptor Pathway ⁶⁴	12.73	UBC KRAS HRAS BRAF
11	MAPK-Erk Pathway ⁶⁷ Show member pathways Actin Dynamics Signaling Pathway ⁶⁷ G Protein-coupled Receptors Signaling ⁶⁷	12.73	PIK3CA KRAS HRAS BRAF
12	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁵ Show member pathways Adipokines and Insulin Signaling Pathways ⁶⁵ Development Thrombopoietin-regulated cell processes ²² IL-15 Signaling Pathways ⁶⁵ IL-2 Signaling Pathways ⁶⁵ IL-21 Signaling Pathways ⁶⁵ IL-4 Signaling Pathways ⁶⁵ IL-7 Signaling Pathways ⁶⁵ IL-9 Pathway ⁶⁴ IL-9 Signaling Pathways ⁶⁵ Immune response IL-9 signaling pathway ²²	12.7	PIK3CA KRAS HRAS BRAF
13	Gastric cancer ³⁷ Show member pathways Breast cancer ³⁷ Hepatocellular carcinoma ³⁷	12.68	PIK3CA KRAS HRAS BRAF
14	Ras signaling pathway ³⁷ Show member pathways Rap1 signaling pathway ³⁷	12.65	PIK3CA KRAS HRAS BRAF
15	Downstream signaling events of B Cell Receptor (BCR) ⁶⁶ Show member pathways Activation of RAS in B cells ⁶⁶ Signaling by the B Cell Receptor (BCR) ⁶⁶	12.64	UBC PIK3CA KRAS HRAS
16	Development HGF signaling pathway ²² Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development Neurotrophin family signaling ²² MET activates PTPN11 ⁶⁶ MET activates STAT3 ⁶⁶ Neurotrophin signaling pathway ³⁷ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.62	PIK3CA KRAS HRAS BRAF
17	Glioma ³⁷ Show member pathways Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.61	PIK3CA KRAS HRAS BRAF
18	Regulation of actin cytoskeleton ³⁷ ¹	12.52	PIK3CA KRAS HRAS BRAF
19	ErbB signaling pathway ³⁷ ¹ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶¹ EGFR tyrosine kinase inhibitor resistance ³⁷ Renal cell carcinoma ³⁷ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.49	PIK3CA KRAS HRAS BRAF
20	Immune response Role of DAP12 receptors in NK cells ²² Show member pathways Immune response CD16 signaling in NK cells ²² Natural killer cell mediated cytotoxicity ³⁷	12.42	PIK3CA KRAS HRAS BRAF
21	mTOR signaling pathway (KEGG) ³⁷ Show member pathways mTOR Signaling Pathway ⁶⁵	12.4	PIK3CA KRAS HRAS BRAF
22	Development FGFR signaling pathway ²² Show member pathways Development FGF-family signaling ²² Development Flt3 signaling ²² FGF Pathway ⁶⁴	12.34	UBC PIK3CA KRAS HRAS
23	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ¹	12.31	PIK3CA KRAS HRAS BRAF
24	MET promotes cell motility ⁶⁶ Show member pathways Alpha 6 Beta 4 signaling pathway ¹ Laminin interactions ⁶⁶ MET activates PTK2 signaling ⁶⁶ MET activates RAP1 and RAC1 ⁶⁶ MET activates RAS signaling ⁶⁶ MET interacts with TNS proteins ⁶⁶ MET Receptor Activation ⁶⁶ MET receptor recycling ⁶⁶ Non-integrin membrane-ECM interactions ⁶⁶ Signaling by MET ⁶⁶ Syndecan interactions ⁶⁶	12.31	UBC PIK3CA KRAS HRAS
25	Oocyte meiosis ³⁷ Show member pathways Progesterone-mediated oocyte maturation ³⁷	12.3	PIK3CA KRAS BRAF
26	CLEC7A (Dectin-1) signaling ⁶⁶ Show member pathways Alternative NF-kappaB pathway ¹ CLEC7A/inflammasome pathway ⁶⁶ C-type lectin receptors (CLRs) ⁶⁶	12.3	UBC MUC1 KRAS HRAS
27	CNTF Signaling ⁶⁴ Show member pathways FLT3 Signaling ⁶⁴ IL-3 Pathway ⁶⁴ Nur77-Induced AICD in Macrophage ⁶⁴ OSM Pathway ⁶⁴	12.28	KRAS HRAS BRAF
28	B Cell Receptor Signaling Pathway (sino) ⁶⁷ Show member pathways B Cell Receptor Signaling Pathway ⁶⁷	12.27	PIK3CA KRAS HRAS
29	Development VEGF signaling via VEGFR2 - generic cascades ²² Show member pathways Development VEGF signaling and activation ²² VEGF - VEGF R2 Signaling Pathways ⁶⁵	12.26	PIK3CA KRAS HRAS BRAF
30	B cell receptor signaling pathway (KEGG) ¹ Show member pathways B cell receptor signaling pathway ³⁷ BCR signaling pathway ¹	12.25	PIK3CA KRAS HRAS BRAF
31	Negative regulation of FGFR1 signaling ⁶⁶ Show member pathways FGFR1 ligand binding and activation ⁶⁶ FGFR1b ligand binding and activation ⁶⁶ FGFR1c and Klotho ligand binding and activation ⁶⁶ FGFR1c ligand binding and activation ⁶⁶ FGFRL1 modulation of FGFR1 signaling ⁶⁶ Negative regulation of FGFR2 signaling ⁶⁶ Negative regulation of FGFR3 signaling ⁶⁶ Negative regulation of FGFR4 signaling ⁶⁶ Signaling by activated point mutants of FGFR1 ⁶⁶ Signaling by FGFR1 ⁶⁶ Signaling by FGFR1 amplification mutants ⁶⁶ Signaling by FGFR3 ⁶⁶ Signaling by FGFR4 ⁶⁶ Spry regulation of FGF signaling ⁶⁶	12.25	UBC PIK3CA KRAS HRAS BRAF
32	Paradoxical activation of RAF signaling by kinase inactive BRAF ⁶⁶ Show member pathways MAP2K and MAPK activation ⁶⁶ Signaling by high-kinase activity BRAF mutants ⁶⁶ Signaling by moderate kinase activity BRAF mutants ⁶⁶ Signaling by RAS mutants ⁶⁶	12.24	KRAS HRAS BRAF
33	Viral carcinogenesis ³⁷	12.24	PIK3CA KRAS HRAS
34	G-protein signaling Ras family GTPases in kinase cascades (scheme) ²² Show member pathways Activation of the AP-1 family of transcription factors ⁶⁶ Immune response Oncostatin M signaling via MAPK in human cells ²² MAPK Cascade ¹ Oncostatin M Signaling Pathway ¹	12.2	KRAS HRAS BRAF
35	Axon guidance ³⁷	12.18	PIK3CA KRAS HRAS
36	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins ²² Show member pathways G-protein signaling G-Protein alpha-12 signaling pathway ²²	12.16	PIK3CA KRAS HRAS BRAF
37	C-type lectin receptor signaling pathway ³⁷ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.16	PIK3CA KRAS HRAS
38	GDNF-Family Ligands and Receptor Interactions ⁶⁴ Show member pathways BDNF Pathway ⁶⁴ Development GDNF family signaling ²²	12.14	PIK3CA KRAS HRAS
39	Signaling by ERBB2 ⁶⁶ Show member pathways Downregulation of ERBB2 signaling ⁶⁶ Downregulation of ERBB2-ERBB3 signaling ⁶⁶ ERBB2 Activates PTK6 Signaling ⁶⁶ ERBB2 Regulates Cell Motility ⁶⁶ GRB2 events in ERBB2 signaling ⁶⁶ PI3K events in ERBB2 signaling ⁶⁶ PI3K events in ERBB4 signaling ⁶⁶ SHC1 events in ERBB2 signaling ⁶⁶ SHC1 events in ERBB4 signaling ⁶⁶	12.14	UBC PIK3CA KRAS HRAS
40	Long-term potentiation ³⁷ Show member pathways Common Pathways Underlying Drug Addiction ¹ Dopamine D1-Like Receptor Family Signaling Pathways ⁶⁵	12.13	KRAS HRAS BRAF
41	Proteoglycans in cancer ³⁷	12.13	PIK3CA KRAS HRAS BRAF
42	EGF/EGFR Signaling Pathway ¹	12.12	KRAS HRAS BRAF
43	Cellular senescence (KEGG) ³⁷	12.11	PIK3CA KRAS HRAS
44	Signaling by FGFR2 in disease ⁶⁶ Show member pathways FGFR2 mutant receptor activation ⁶⁶ Signaling by FGFR in disease ⁶⁶ Signaling by FGFR2 IIIa TM ⁶⁶	12.1	PIK3CA KRAS HRAS
45	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁵ Show member pathways Akt Signaling Pathway ⁶⁵	12.09	PIK3CA KRAS HRAS BRAF
46	AKT Signaling Pathway ⁶⁷	12.08	PIK3CA KRAS HRAS
47	NGF Pathway ⁶⁴ Show member pathways TRKA Signaling ⁶⁴	12.08	KRAS HRAS BRAF
48	Longevity regulating pathway ³⁷ Show member pathways Longevity regulating pathway - multiple species ³⁷	12.08	PIK3CA KRAS HRAS
49	Development EGFR signaling via small GTPases ²² Show member pathways Development EGFR signaling via PIP3 ²² Development PDGF signaling via MAPK cascades ²² PDGF Pathway ¹	12.08	PIK3CA KRAS HRAS
50	Cell surface interactions at the vascular wall ⁶⁶ Show member pathways Fibronectin matrix formation ⁶⁶ PECAM1 interactions ⁶⁶ Tie2 Signaling ⁶⁶	12.05	PIK3CA KRAS HRAS CEACAM5

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GO Terms for Apocrine Adenoma

Cellular components related to Apocrine Adenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	9.23	UBC SLC4A9 PIK3CA MUC1 KRAS HRAS

Biological processes related to Apocrine Adenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of apoptotic process	GO:0043066	9.76	UBC SOX10 CEACAM5 BRAF
2	positive regulation of gene expression	GO:0010628	9.67	SOX10 KRAS HRAS BRAF
3	MAPK cascade	GO:0000165	9.65	KRAS HRAS BRAF
4	T cell receptor signaling pathway	GO:0050852	9.5	PIK3CA HRAS BRAF
5	cytokine-mediated signaling pathway	GO:0019221	9.46	UBC PIK3CA MUC1 KRAS
6	regulation of long-term neuronal synaptic plasticity	GO:0048169	9.43	KRAS HRAS
7	negative regulation of anoikis	GO:2000811	9.4	PIK3CA CEACAM5
8	response to isolation stress	GO:0035900	9.26	KRAS HRAS
9	stimulatory C-type lectin receptor signaling pathway	GO:0002223	9.13	MUC1 KRAS HRAS
10	negative regulation of neuron apoptotic process	GO:0043524	8.92	PIK3CA KRAS HRAS BRAF

Sources

Sources for Apocrine Adenoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ TGDB

⁷¹ Tocris

⁷² UMLS

⁷³ UMLS via Orphanet

⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia