MCID: APC003
MIFTS: 37

Apocrine Adenoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Apocrine Adenoma

MalaCards integrated aliases for Apocrine Adenoma:

Name: Apocrine Adenoma 12 15 74
Tubular Apocrine Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3895
NCIt 51 C27527 C4168
SNOMED-CT 69 36318001
UMLS 74 C0334345

Summaries for Apocrine Adenoma

MalaCards based summary : Apocrine Adenoma, also known as tubular apocrine adenoma, is related to syringocystadenoma papilliferum and schimmelpenning-feuerstein-mims syndrome. An important gene associated with Apocrine Adenoma is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are Innate Immune System and HIV Life Cycle. Affiliated tissues include breast, lung and skin, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Apocrine Adenoma

Diseases related to Apocrine Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 syringocystadenoma papilliferum 31.1 KRAS MUC1
2 schimmelpenning-feuerstein-mims syndrome 30.2 HRAS KRAS
3 nevus, epidermal 29.8 HRAS KRAS PIK3CA
4 squamous cell carcinoma 29.3 BRAF HRAS MUC1 PIK3CA
5 adenocarcinoma 29.3 BRAF HRAS KRAS MUC1 PIK3CA
6 breast apocrine adenoma 12.3
7 hidrocystoma 11.6
8 adenoma 10.8
9 hyperplastic polyposis syndrome 10.3 BRAF KRAS
10 apocrine adenocarcinoma 10.3
11 rare adenocarcinoma of the breast 10.2 KRAS PIK3CA
12 mature teratoma 10.2 BRAF KRAS
13 pilocytic astrocytoma 10.2 BRAF KRAS
14 pancreatic cystadenocarcinoma 10.2 CEACAM5 KRAS
15 erdheim-chester disease 10.2 BRAF PIK3CA
16 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.2 KRAS PIK3CA
17 undifferentiated pleomorphic sarcoma 10.2 KRAS PIK3CA
18 papillary tumor of the pineal region 10.2 BRAF MUC1
19 pilomyxoid astrocytoma 10.2 BRAF KRAS
20 adenofibroma 10.2 BRAF MUC1
21 papillary adenocarcinoma 10.2 CEACAM5 MUC1
22 malignant spiradenoma 10.2 CEACAM5 PIK3CA
23 periampullary adenoma 10.1 HRAS KRAS
24 paronychia 10.1 HRAS KRAS
25 hidradenoma 10.1 MUC1 PIK3CA
26 bile duct cysts 10.1 HRAS KRAS
27 appendix disease 10.1 HRAS KRAS
28 breast mucoepidermoid carcinoma 10.1 CEACAM5 MUC1
29 nasal cavity adenocarcinoma 10.1 HRAS KRAS
30 secondary hypertrophic osteoarthropathy 10.1 HRAS KRAS
31 anal canal adenocarcinoma 10.1 HRAS KRAS
32 angiosarcoma 10.1 KRAS MUC1
33 spitz nevus 10.1 BRAF HRAS
34 bile duct mucoepidermoid carcinoma 10.1 CEACAM5 MUC1
35 breast adenomyoepithelioma 10.1 CEACAM5 PIK3CA
36 serous cystadenocarcinoma 10.1 HRAS PIK3CA
37 eccrine papillary adenoma 10.1
38 breast myoepithelial neoplasm 10.1 CEACAM5 PIK3CA
39 nodular hidradenoma 10.1 CEACAM5 MUC1
40 prostate adenoid cystic carcinoma 10.1 HRAS PIK3CA
41 pseudomyxoma peritonei 10.1 KRAS MUC1
42 bile duct cystadenocarcinoma 10.1 CEACAM5 MUC1
43 ovarian cystadenocarcinoma 10.1 HRAS KRAS
44 ethmoid sinus cancer 10.1 HRAS PIK3CA
45 ethmoid sinus adenocarcinoma 10.1 HRAS PIK3CA
46 mucinous ovarian cystadenoma 10.1 CEACAM5 MUC1
47 core binding factor acute myeloid leukemia 10.1 HRAS KRAS
48 mucinous lung adenocarcinoma 10.1 HRAS KRAS
49 mucinous adenocarcinoma 10.1 KRAS MUC1
50 leopard syndrome 10.1 BRAF HRAS

Graphical network of the top 20 diseases related to Apocrine Adenoma:



Diseases related to Apocrine Adenoma

Symptoms & Phenotypes for Apocrine Adenoma

GenomeRNAi Phenotypes related to Apocrine Adenoma according to GeneCards Suite gene sharing:

27 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.03 BRAF HRAS KRAS MUC1 PIK3CA
2 Decreased viability GR00106-A-0 10.03 KRAS
3 Decreased viability GR00221-A-1 10.03 HRAS KRAS PIK3CA
4 Decreased viability GR00221-A-2 10.03 HRAS KRAS PIK3CA
5 Decreased viability GR00221-A-3 10.03 HRAS
6 Decreased viability GR00221-A-4 10.03 BRAF PIK3CA
7 Decreased viability GR00301-A 10.03 BRAF KRAS
8 Decreased viability GR00381-A-1 10.03 BRAF KRAS
9 Decreased viability GR00402-S-2 10.03 BRAF HRAS KRAS MUC1 PIK3CA
10 Decreased cell migration GR00055-A-1 9.55 BRAF HRAS KRAS MUC1 PIK3CA
11 Increased cell migration GR00055-A-3 8.92 BRAF HRAS KRAS PIK3CA

MGI Mouse Phenotypes related to Apocrine Adenoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 BRAF HRAS KRAS PIK3CA

Drugs & Therapeutics for Apocrine Adenoma

Search Clinical Trials , NIH Clinical Center for Apocrine Adenoma

Genetic Tests for Apocrine Adenoma

Anatomical Context for Apocrine Adenoma

MalaCards organs/tissues related to Apocrine Adenoma:

42
Breast, Lung, Skin, Pancreas, Thyroid, Brain, Colon

Publications for Apocrine Adenoma

Articles related to Apocrine Adenoma:

(show all 48)
# Title Authors Year
1
Apocrine Adenoma of the External Auditory Canal with Pseudoepitheliomatous Hyperplasia. ( 30915250 )
2019
2
Blaschkoid distribution of composite syringocystadenoma papilliferum and tubular apocrine adenoma without naevus sebaceous. ( 30251370 )
2019
3
Tubular apocrine adenoma: A rare and controversial tumor. ( 29863779 )
2019
4
Tubular Apocrine Adenoma on Vulva: An Unusual Location. ( 30258809 )
2018
5
Ectopic Tubular Papillary Apocrine Adenoma on the Eyelid: A Case Report of Misleading Clinical Presentation and Location. ( 30320096 )
2018
6
BRAF and KRAS mutations in tubular apocrine adenoma and papillary eccrine adenoma of the skin. ( 29241739 )
2018
7
Syringocystadenoma papilliferum combined with a tubular apocrine adenoma. ( 29166517 )
2017
8
Tubular Apocrine Adenoma in Association with an Apocrine Hidrocystoma. ( 27772650 )
2016
9
Tubular apocrine adenoma clinically and dermoscopically mimicking basal cell carcinoma. ( 25037809 )
2014
10
Case of tubular apocrine adenoma with follicular differentiation located on the trunk. ( 21906134 )
2012
11
Tubular apocrine adenoma of the nose. ( 21252032 )
2011
12
Squamous cell carcinoma, syringocystadenoma papilliferum and apocrine adenoma arising in a nevus sebaceus of Jadassohn. ( 21393932 )
2011
13
Lipomatous apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. ( 21854651 )
2011
14
Syringocystadenoma papilliferum of the back combined with a tubular apocrine adenoma. ( 22148038 )
2011
15
Syringocystadenoma Papilliferum in Co-existence with Tubular Apocrine Adenoma on the Calf. ( 22148043 )
2011
16
Tubular apocrine adenoma: presentation in the vaginal introitus of an eight-year-old. ( 20537077 )
2010
17
A Case of Tubular Apocrine Adenoma with Syringocystadenoma Papilliferum that Developed in a Nevus Sebaceus. ( 20711270 )
2010
18
Apocrine adenocarcinoma of the right eyelid and apocrine adenoma of the left maxillary sinus. ( 18982051 )
2008
19
Apocrine adenoma of the breast. ( 18491794 )
2008
20
Naevus sebaceus on the female breast accompanied with a tubular apocrine adenoma and a syringocystadenoma papilliferum. ( 17535243 )
2007
21
Axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia. ( 17868540 )
2007
22
Apocrine adenoma of the breast coexistent with invasive carcinoma. ( 17936522 )
2007
23
Mohs micrographic surgery for tubular apocrine adenoma. ( 17076735 )
2006
24
Perianal apocrine adenocarcinoma arising in a benign apocrine adenoma; first case report and review of the literature. ( 15677547 )
2005
25
Tubular apocrine adenoma--an unusual eyelid tumour. ( 15105822 )
2005
26
Tubular apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. ( 16354370 )
2005
27
Multifocal papillary apocrine adenoma arising in a systematized linear epidermal nevus. ( 15186052 )
2004
28
A case of tubular apocrine adenoma with syringocystadenoma papilliferum arising in nevus sebaceus. ( 15235197 )
2004
29
A case of ductal apocrine carcinoma in the left axilla with tubular apocrine adenoma in the right axilla. ( 12598714 )
2003
30
Tubular apocrine adenoma in association with syringocystadenoma papilliferum. ( 12639465 )
2003
31
Three-millimeter apocrine adenoma in a man: a case report and review of the literature. ( 14567753 )
2003
32
Apocrine adenoma of the breast: diagnosis on large core needle biopsy. ( 11358045 )
2001
33
Spiradenoma associated with apocrine adenoma component. ( 9122033 )
1996
34
Tubular apocrine adenoma with eccrine and apocrine immunophenotypes or papillary tubular adenoma? ( 8599457 )
1995
35
Is tubular apocrine adenoma a distinct clinical entity? ( 8238787 )
1993
36
Tubular apocrine adenoma and papillary eccrine adenoma. Entities or unity? ( 1566975 )
1992
37
Apocrine adenoma of the breast: report of a case with investigation of lectin binding patterns in apocrine breast lesions. ( 2362943 )
1990
38
[Tubular apocrine adenoma. Description of 4 cases]. ( 2214926 )
1990
39
A case of tubular apocrine adenoma with syringocystadenoma papilliferum. ( 2551940 )
1989
40
Apocrine adenoma presenting as gynaecomastia in a 14-year-old boy. ( 3235060 )
1988
41
Tubular apocrine adenoma. ( 3036918 )
1987
42
Apocrine adenoma of the breast. ( 3754126 )
1986
43
Tubular apocrine adenoma with perineural invasion. ( 6490990 )
1984
44
Apocrine adenoma versus pocrine carcinoma. Report of two cases. ( 7364989 )
1980
45
Tubular apocrine adenoma. ( 993400 )
1976
46
Tubular apocrine adenoma. ( 4345346 )
1973
47
An unusual tubular apocrine adenoma. ( 4113017 )
1972
48
Apocrine adenoma of the anus. ( 13141230 )
1954

Variations for Apocrine Adenoma

Expression for Apocrine Adenoma

Search GEO for disease gene expression data for Apocrine Adenoma.

Pathways for Apocrine Adenoma

Pathways related to Apocrine Adenoma according to GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.86 BRAF HRAS KRAS MUC1 PIK3CA UBC
2
Show member pathways
13.54 BRAF HRAS KRAS MUC1 PIK3CA UBC
3
Show member pathways
13.41 BRAF HRAS KRAS PIK3CA UBC
4
Show member pathways
13.37 BRAF HRAS KRAS PIK3CA UBC
5
Show member pathways
13.11 BRAF HRAS KRAS MUC1 PIK3CA UBC
6
Show member pathways
12.92 BRAF HRAS KRAS UBC
7
Show member pathways
12.83 BRAF HRAS KRAS PIK3CA
8
Show member pathways
12.82 BRAF HRAS KRAS PIK3CA
9
Show member pathways
12.81 BRAF HRAS KRAS PIK3CA
10
Show member pathways
12.8 BRAF HRAS KRAS PIK3CA
11
Show member pathways
12.78 BRAF HRAS KRAS PIK3CA
12
Show member pathways
12.77 BRAF HRAS KRAS PIK3CA
13 12.75 BRAF HRAS KRAS PIK3CA
14
Show member pathways
12.71 BRAF HRAS KRAS UBC
15
Show member pathways
12.7 BRAF HRAS KRAS PIK3CA
16
Show member pathways
12.68 BRAF HRAS KRAS PIK3CA
17
Show member pathways
12.66 BRAF HRAS KRAS PIK3CA
18
Show member pathways
12.62 BRAF HRAS KRAS PIK3CA
19
Show member pathways
12.61 HRAS KRAS PIK3CA UBC
20
Show member pathways
12.59 BRAF HRAS KRAS PIK3CA
21
Show member pathways
12.59 BRAF HRAS KRAS PIK3CA
22 12.52 BRAF HRAS KRAS PIK3CA
23
Show member pathways
12.5 HRAS KRAS PIK3CA
24
Show member pathways
12.5 HRAS KRAS PIK3CA
25
Show member pathways
12.49 HRAS KRAS PIK3CA
26
Show member pathways
12.48 BRAF HRAS KRAS PIK3CA
27 12.44 HRAS KRAS PIK3CA
28
Show member pathways
12.41 HRAS KRAS PIK3CA
29
Show member pathways
12.41 BRAF HRAS KRAS PIK3CA
30
Show member pathways
12.39 BRAF HRAS KRAS PIK3CA
31
Show member pathways
12.38 HRAS KRAS PIK3CA
32
Show member pathways
12.35 BRAF HRAS KRAS
33
Show member pathways
12.34 HRAS KRAS PIK3CA
34
Show member pathways
12.34 HRAS KRAS PIK3CA
35
Show member pathways
12.33 HRAS KRAS PIK3CA
36
Show member pathways
12.33 HRAS KRAS PIK3CA UBC
37
Show member pathways
12.33 HRAS KRAS PIK3CA UBC
38
Show member pathways
12.3 BRAF HRAS KRAS PIK3CA
39
Show member pathways
12.3 HRAS KRAS MUC1 UBC
40 12.29 HRAS KRAS PIK3CA
41
Show member pathways
12.29 BRAF KRAS PIK3CA
42
Show member pathways
12.28 BRAF HRAS KRAS
43
Show member pathways
12.27 HRAS KRAS PIK3CA
44
Show member pathways
12.27 BRAF HRAS KRAS PIK3CA
45
Show member pathways
12.25 HRAS PIK3CA UBC
46
Show member pathways
12.25 BRAF HRAS KRAS PIK3CA
47
Show member pathways
12.24 BRAF HRAS KRAS
48 12.23 HRAS KRAS PIK3CA
49
Show member pathways
12.21 BRAF HRAS KRAS MUC1 PIK3CA
50
Show member pathways
12.2 BRAF HRAS KRAS

GO Terms for Apocrine Adenoma

Cellular components related to Apocrine Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.17 BRAF CEACAM5 HRAS KRAS MUC1 PIK3CA

Biological processes related to Apocrine Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.61 BRAF HRAS KRAS
2 T cell receptor signaling pathway GO:0050852 9.5 BRAF HRAS PIK3CA
3 visual learning GO:0008542 9.46 BRAF KRAS
4 cytokine-mediated signaling pathway GO:0019221 9.46 KRAS MUC1 PIK3CA UBC
5 regulation of long-term neuronal synaptic plasticity GO:0048169 9.4 HRAS KRAS
6 negative regulation of anoikis GO:2000811 9.37 CEACAM5 PIK3CA
7 response to isolation stress GO:0035900 9.26 HRAS KRAS
8 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.13 HRAS KRAS MUC1
9 negative regulation of neuron apoptotic process GO:0043524 8.92 BRAF HRAS KRAS PIK3CA

Sources for Apocrine Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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