MCID: APC002
MIFTS: 30

Apocrine Adenosis of Breast

Categories: Cancer diseases

Aliases & Classifications for Apocrine Adenosis of Breast

MalaCards integrated aliases for Apocrine Adenosis of Breast:

Name: Apocrine Adenosis of Breast 12 15
Apocrine Adenosis of the Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5999
NCIt 49 C5198
UMLS 71 C1332314

Summaries for Apocrine Adenosis of Breast

Disease Ontology : 12 A non-proliferative fibrocystic change of the breast that is characterized by sclerosing adenosis with apocrine change.

MalaCards based summary : Apocrine Adenosis of Breast, also known as apocrine adenosis of the breast, is related to apocrine adenocarcinoma and in situ carcinoma. An important gene associated with Apocrine Adenosis of Breast is MYCL (MYCL Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Endometrial cancer. Affiliated tissues include breast, b cells and ovary, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

Related Diseases for Apocrine Adenosis of Breast

Diseases related to Apocrine Adenosis of Breast via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 apocrine adenocarcinoma 30.8 PGR ERBB2
2 in situ carcinoma 30.1 TP53 PGR ERBB2
3 ductal carcinoma in situ 30.1 TP53 PGR ERBB2
4 breast disease 29.8 TP53 PGR ERBB2
5 non-proliferative fibrocystic change of the breast 10.4 MYCL ERBB2
6 breast cancer 10.3
7 bent bone dysplasia syndrome 10.3 FGFR2 ERBB2
8 gastric papillary adenocarcinoma 10.3 TP53 ERBB2
9 breast squamous cell carcinoma 10.3 TP53 ERBB2
10 rare head and neck tumor 10.3 TP53 FGFR2
11 parotid gland cancer 10.3 TP53 ERBB2
12 pleomorphic adenoma carcinoma 10.3 TP53 ERBB2
13 large intestine adenocarcinoma 10.2 TP53 ERBB2
14 glassy cell carcinoma of the cervix 10.2 PGR ERBB2
15 adult teratoma 10.2 TP53 FGFR2
16 scirrhous adenocarcinoma 10.2 PGR ERBB2
17 wolffian duct adenocarcinoma 10.2 TP53 FGFR2
18 splenic diffuse red pulp small b-cell lymphoma 10.2 TP53 CCNA2
19 ovarian carcinosarcoma 10.2 TP53 ERBB2
20 breast juvenile papillomatosis 10.2 PGR ERBB2
21 breast scirrhous carcinoma 10.2 PGR ERBB2
22 sweat gland neoplasm 10.2 TP53 ERBB2
23 lipid-rich breast carcinoma 10.2 PGR ERBB2
24 oncocytic breast carcinoma 10.2 PGR ERBB2
25 breast papillary carcinoma 10.2 PGR ERBB2
26 granulosa cell tumor of the ovary 10.2 TP53 ERBB2
27 breast adenoid cystic carcinoma 10.2 PGR ERBB2
28 breast metaplastic carcinoma 10.2 PGR ERBB2
29 breast mucinous carcinoma 10.2 PGR ERBB2
30 uterine corpus serous adenocarcinoma 10.2 TP53 ERBB2
31 lipid-rich carcinoma 10.2 PGR ERBB2
32 linitis plastica 10.2 PGR ERBB2
33 thyroid lymphoma 10.2 TP53 CCNA2
34 progesterone-receptor negative breast cancer 10.2 PGR ERBB2
35 peritoneum cancer 10.2 TP53 ERBB2
36 apocrine sweat gland neoplasm 10.2 PGR ERBB2
37 hypertelorism, microtia, facial clefting syndrome 10.2 FGFR2 DNTT
38 uterine body mixed cancer 10.2 TP53 ERBB2
39 breast osteosarcoma 10.2 PGR ERBB2
40 cribriform carcinoma 10.2 PGR ERBB2
41 breast neuroendocrine neoplasm 10.2 PGR ERBB2
42 mature teratoma 10.2 TP53 ERBB2
43 intracystic papillary adenoma 10.2 PGR ERBB2
44 bartholin's gland adenoma 10.2 TP53 PGR
45 bartholin's gland benign neoplasm 10.2 TP53 PGR
46 vestibular gland benign neoplasm 10.2 TP53 PGR
47 progesterone-receptor positive breast cancer 10.1 PGR ERBB2
48 intraductal papilloma 10.1 PGR ERBB2
49 ovarian seromucinous carcinoma 10.1 TP53 PGR
50 sebaceous adenocarcinoma 10.1 TP53 ERBB2

Graphical network of the top 20 diseases related to Apocrine Adenosis of Breast:



Diseases related to Apocrine Adenosis of Breast

Symptoms & Phenotypes for Apocrine Adenosis of Breast

GenomeRNAi Phenotypes related to Apocrine Adenosis of Breast according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 9.46 BCL2L1 ERBB2
2 Decreased viability with paclitaxel GR00179-A-2 9.46 BCL2L1
3 Decreased viability with paclitaxel GR00179-A-3 9.46 BCL2L1
4 Increased viability with nutlin-3 GR00123-A 8.96 MYCL TP53
5 Synthetic lethal with cisplatin GR00101-A-1 8.62 BCL2L1 MCL1

MGI Mouse Phenotypes related to Apocrine Adenosis of Breast:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 BCL2L1 CCNA2 ERBB2 FGFR2 MCL1 PGR
2 hematopoietic system MP:0005397 10.01 BCL2L1 CCNA2 DNTT FGFR2 MCL1 MYCL
3 immune system MP:0005387 9.97 BCL2L1 CCNA2 DNTT FGFR2 MCL1 MYCL
4 embryo MP:0005380 9.93 CCNA2 ERBB2 FGFR2 MCL1 PGR TP53
5 endocrine/exocrine gland MP:0005379 9.91 BCL2L1 ERBB2 FGFR2 MCL1 PGR TP53
6 mortality/aging MP:0010768 9.86 BCL2L1 CCNA2 ERBB2 FGFR2 MCL1 MYCL
7 integument MP:0010771 9.8 BCL2L1 ERBB2 FGFR2 MCL1 PGR TP53
8 neoplasm MP:0002006 9.55 BCL2L1 ERBB2 FGFR2 PGR TP53
9 normal MP:0002873 9.5 DNTT ERBB2 FGFR2 MCL1 MYCL PGR
10 reproductive system MP:0005389 9.1 BCL2L1 ERBB2 FGFR2 MCL1 PGR TP53

Drugs & Therapeutics for Apocrine Adenosis of Breast

Search Clinical Trials , NIH Clinical Center for Apocrine Adenosis of Breast

Genetic Tests for Apocrine Adenosis of Breast

Anatomical Context for Apocrine Adenosis of Breast

MalaCards organs/tissues related to Apocrine Adenosis of Breast:

40
Breast, B Cells, Ovary, Myeloid, Bone, Bone Marrow, Colon

Publications for Apocrine Adenosis of Breast

Articles related to Apocrine Adenosis of Breast:

# Title Authors PMID Year
1
Atypical apocrine adenosis of the breast: long-term follow-up in 37 patients. 61
22288965 2012
2
Cell turnover in apocrine metaplasia and apocrine adenosis of the breast. 61
20123450 2010
3
Fine needle aspiration cytology of atypical apocrine adenosis of the breast. 61
17916092 2009
4
Cell cycle alterations and their relationship to proliferation in apocrine adenosis of the breast. 61
19236511 2009
5
Fine-needle aspiration cytology of apocrine adenosis of the breast: report on three cases. 61
17427223 2007
6
Apocrine adenosis of the breast: clonal evidence of neoplasia. 61
11260302 2001
7
Loss of heterozygosity and allelic imbalance in apocrine adenosis of the breast. 61
11425268 2001
8
c-erbB2 oncoprotein expression, gene amplification, and chromosome 17 aneusomy in apocrine adenosis of the breast. 61
10861572 2000
9
Immunohistochemical localisation of androgen receptor in apocrine metaplasia and apocrine adenosis of the breast: relation to oestrogen and progesterone receptors. 61
10690175 1999
10
Atypical apocrine adenosis of the breast: a clinicopathologic study of 37 patients with 8.7-year follow-up. 61
8640702 1996

Variations for Apocrine Adenosis of Breast

Expression for Apocrine Adenosis of Breast

Search GEO for disease gene expression data for Apocrine Adenosis of Breast.

Pathways for Apocrine Adenosis of Breast

Pathways related to Apocrine Adenosis of Breast according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.08 TP53 MCL1 FGFR2 ERBB2 BCL2L1
2
Show member pathways
12.51 TP53 FGFR2 ERBB2 CCNA2 BCL2L1
3 12.44 TP53 FGFR2 ERBB2 CCNA2 BCL2L1
4
Show member pathways
12.35 TP53 FGFR2 ERBB2 BCL2L1
5
Show member pathways
12.27 TP53 MCL1 FGFR2 ERBB2 CCNA2 BCL2L1
6
Show member pathways
12.22 TP53 PGR FGFR2 ERBB2 BCL2L1
7
Show member pathways
12.13 TP53 FGFR2 ERBB2 BCL2L1
8 12.09 TP53 CCNA2 BCL2L1
9 12 TP53 CCNA2 BCL2L1
10
Show member pathways
11.96 TP53 FGFR2 ERBB2 BCL2L1
11 11.74 TP53 MCL1 BCL2L1
12 11.5 TP53 ERBB2 BCL2L1
13 11.45 TP53 FGFR2 ERBB2
14 11.09 TP53 CCNA2
15 11 TP53 MCL1 BCL2L1
17 10.88 MCL1 BCL2L1
18 10.63 TP53 MCL1 CCNA2 BCL2L1
19 10.6 TP53 BCL2L1

GO Terms for Apocrine Adenosis of Breast

Cellular components related to Apocrine Adenosis of Breast according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.8 TP53 PGR MYCL MCL1 FGFR2 DNTT
2 nucleus GO:0005634 9.61 TP53 PGR MYCL MCL1 FGFR2 ERBB2
3 mitochondrial outer membrane GO:0005741 9.33 PGR MCL1 BCL2L1
4 Bcl-2 family protein complex GO:0097136 8.62 MCL1 BCL2L1

Biological processes related to Apocrine Adenosis of Breast according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.76 TP53 MCL1 FGFR2 BCL2L1
2 in utero embryonic development GO:0001701 9.58 TP53 FGFR2 BCL2L1
3 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.54 TP53 BCL2L1
4 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.52 MCL1 BCL2L1
5 lung alveolus development GO:0048286 9.51 PGR FGFR2
6 base-excision repair GO:0006284 9.49 TP53 DNTT
7 embryonic organ development GO:0048568 9.48 TP53 FGFR2
8 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.43 MCL1 BCL2L1
9 cellular response to gamma radiation GO:0071480 9.37 TP53 BCL2L1
10 regulation of ERK1 and ERK2 cascade GO:0070372 9.32 FGFR2 ERBB2
11 negative regulation of intrinsic apoptotic signaling pathway GO:2001243 9.26 MCL1 BCL2L1
12 release of cytochrome c from mitochondria GO:0001836 9.16 TP53 BCL2L1
13 regulation of mitochondrial membrane permeability GO:0046902 8.96 TP53 BCL2L1
14 wound healing GO:0042060 8.8 TP53 FGFR2 ERBB2

Molecular functions related to Apocrine Adenosis of Breast according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.26 TP53 MCL1 ERBB2 BCL2L1
2 BH3 domain binding GO:0051434 8.62 MCL1 BCL2L1

Sources for Apocrine Adenosis of Breast

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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