MCID: APC005
MIFTS: 30

Apocrine Sweat Gland Neoplasm

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Apocrine Sweat Gland Neoplasm

MalaCards integrated aliases for Apocrine Sweat Gland Neoplasm:

Name: Apocrine Sweat Gland Neoplasm 12 15
Apocrine Neoplasm 73
Apocrine Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5876
NCIt 50 C6798
UMLS 73 C1332318

Summaries for Apocrine Sweat Gland Neoplasm

MalaCards based summary : Apocrine Sweat Gland Neoplasm, also known as apocrine neoplasm, is related to syringocystadenoma papilliferum and anus basaloid carcinoma. An important gene associated with Apocrine Sweat Gland Neoplasm is CYLD (CYLD Lysine 63 Deubiquitinase), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include skin, breast and tonsil, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Apocrine Sweat Gland Neoplasm

Diseases related to Apocrine Sweat Gland Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 syringocystadenoma papilliferum 11.1
2 anus basaloid carcinoma 10.2 CYLD KRT7
3 malignant syringoma 10.2 KRT15 KRT7
4 inverted transitional papilloma 10.1 KRT5 KRT7
5 infiltrative basal cell carcinoma 10.1 KRT15 KRT7
6 balloon cell malignant melanoma 10.1 KRT5 KRT7
7 ceruminoma 10.1 KRT5 KRT7
8 apocrine adenocarcinoma 10.1 KRT15 KRT5
9 malignant spiradenoma 10.1 KRT5 KRT7
10 benign mesothelioma 10.1 KRT5 KRT7
11 sensory organ benign neoplasm 10.1 KRT5 KRT7
12 bile duct mucoepidermoid carcinoma 10.1 KRT5 KRT7
13 middle ear adenoma 10.1 KRT5 KRT7
14 malignant biphasic mesothelioma 10.1 KRT5 KRT7
15 peritoneum cancer 10.1 KRT5 KRT7
16 gastric squamous cell carcinoma 10.1 KRT5 KRT7
17 anus adenocarcinoma 10.1 KRT7 MFGE8
18 oncocytic breast carcinoma 10.1 KRT14 KRT7
19 cystadenofibroma 10.1 KRT5 KRT7
20 mucoepidermoid carcinoma 10.1 KRT14 KRT7
21 necrotizing sialometaplasia 10.1 KRT5 KRT7
22 lichen planopilaris 10.1 KRT14 KRT5
23 epidermolysis bullosa simplex, autosomal recessive 1 10.1 KRT14 KRT5
24 anus cancer 10.1 KRT5 KRT7
25 epidermolysis bullosa simplex 10.1 KRT14 KRT5
26 hidradenocarcinoma 10.1 KRT5 KRT7
27 epidermolysis bullosa simplex, localized 10.1 KRT14 KRT5
28 epidermolysis bullosa simplex, generalized 10.1 KRT14 KRT5
29 cystitis cystica 10.1 KRT5 KRT7
30 breast squamous cell carcinoma 10.1 KRT14 KRT5
31 epidermolysis bullosa simplex with mottled pigmentation 10.1 KRT14 KRT5
32 epithelial-myoepithelial carcinoma 10.1 KRT14 KRT7
33 vesiculobullous skin disease 10.1 KRT14 KRT5
34 epidermolysis bullosa simplex, dowling-meara type 10.1 KRT14 KRT5
35 white sponge nevus 1 10.0 KRT14 KRT7
36 large cell carcinoma 10.0 KRT5 KRT7
37 pre-malignant neoplasm 10.0 KRT14 KRT5
38 in situ carcinoma 10.0 KRT14 KRT5
39 eccrine sweat gland neoplasm 10.0 KRT15 KRT5 KRT7
40 skin benign neoplasm 10.0 KRT14 KRT5
41 proliferating trichilemmal cyst 10.0 KRT7 KRT8
42 endolymphatic sac tumor 10.0 KRT7 KRT8
43 spiradenoma 10.0 CYLD KRT14 KRT7
44 cutaneous adenocystic carcinoma 10.0 KRT7 KRT8
45 adenoid squamous cell carcinoma 10.0 KRT7 KRT8
46 nasal cavity cancer 10.0 KRT7 KRT8
47 pleomorphic carcinoma 10.0 KRT7 KRT8
48 mucinous tubular and spindle renal cell carcinoma 10.0 KRT7 KRT8
49 thymus lipoma 10.0 KRT7 KRT8
50 breast benign neoplasm 10.0 KRT14 KRT15 KRT5

Graphical network of the top 20 diseases related to Apocrine Sweat Gland Neoplasm:



Diseases related to Apocrine Sweat Gland Neoplasm

Symptoms & Phenotypes for Apocrine Sweat Gland Neoplasm

GenomeRNAi Phenotypes related to Apocrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.74 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.74 KRT5 SOX10
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.74 SOX10
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.74 KRT5 KRT8
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.74 KRT5
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.74 KRT8
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.74 KRT7
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.74 KRT5 KRT7 KRT8
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.74 KRT7
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.74 KRT5 KRT7 SOX10

MGI Mouse Phenotypes related to Apocrine Sweat Gland Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.63 CYLD KRT14 KRT15 KRT5 KRT8 SOX10
2 integument MP:0010771 9.35 CYLD KRT14 KRT5 MFGE8 SOX10
3 neoplasm MP:0002006 8.92 CYLD KRT14 MFGE8 SOX10

Drugs & Therapeutics for Apocrine Sweat Gland Neoplasm

Search Clinical Trials , NIH Clinical Center for Apocrine Sweat Gland Neoplasm

Genetic Tests for Apocrine Sweat Gland Neoplasm

Anatomical Context for Apocrine Sweat Gland Neoplasm

MalaCards organs/tissues related to Apocrine Sweat Gland Neoplasm:

41
Skin, Breast, Tonsil, Prostate, Thymus

Publications for Apocrine Sweat Gland Neoplasm

Articles related to Apocrine Sweat Gland Neoplasm:

# Title Authors Year
1
Granular cell tumor in male breast masquerading as atypical apocrine neoplasm: A potential diagnostic pitfall in fine needle aspiration cytology. ( 27016396 )
2016
2
A true epidermotropic apocrine neoplasm in the form of perianal Paget's disease: a case report. ( 23786719 )
2013

Variations for Apocrine Sweat Gland Neoplasm

Expression for Apocrine Sweat Gland Neoplasm

Search GEO for disease gene expression data for Apocrine Sweat Gland Neoplasm.

Pathways for Apocrine Sweat Gland Neoplasm

Pathways related to Apocrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.77 KRT14 KRT15 KRT5 KRT7 KRT8
2 11.92 KRT5 KRT7 KRT8
3
Show member pathways
11.48 KRT14 KRT15 KRT5 KRT7 KRT8
4
Show member pathways
11.29 KRT14 KRT5 KRT7 KRT8
5 11.24 KRT14 KRT5

GO Terms for Apocrine Sweat Gland Neoplasm

Cellular components related to Apocrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.63 KRT14 KRT15 KRT5 KRT7 KRT8 MFGE8
2 cell periphery GO:0071944 9.26 KRT14 KRT8
3 keratin filament GO:0045095 9.26 KRT14 KRT5 KRT7 KRT8
4 intermediate filament GO:0005882 9.02 KRT14 KRT15 KRT5 KRT7 KRT8

Biological processes related to Apocrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.35 KRT14 KRT15 KRT5 KRT7 KRT8
2 epidermis development GO:0008544 9.33 KRT14 KRT15 KRT5
3 hemidesmosome assembly GO:0031581 9.26 KRT14 KRT5
4 cornification GO:0070268 9.02 KRT14 KRT15 KRT5 KRT7 KRT8

Molecular functions related to Apocrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.13 KRT14 KRT15 KRT5
2 scaffold protein binding GO:0097110 8.8 KRT15 KRT5 KRT8

Sources for Apocrine Sweat Gland Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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