MCID: APC005
MIFTS: 31

Apocrine Sweat Gland Neoplasm

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Apocrine Sweat Gland Neoplasm

MalaCards integrated aliases for Apocrine Sweat Gland Neoplasm:

Name: Apocrine Sweat Gland Neoplasm 12 15
Apocrine Neoplasm 70
Apocrine Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5876
NCIt 50 C6798
UMLS 70 C1332318

Summaries for Apocrine Sweat Gland Neoplasm

MalaCards based summary : Apocrine Sweat Gland Neoplasm, also known as apocrine neoplasm, is related to syringocystadenoma papilliferum and anus basaloid carcinoma. An important gene associated with Apocrine Sweat Gland Neoplasm is CYLD (CYLD Lysine 63 Deubiquitinase), and among its related pathways/superpathways are Keratinization and Estrogen signaling pathway (KEGG). Affiliated tissues include breast, skin and liver, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Related Diseases for Apocrine Sweat Gland Neoplasm

Diseases related to Apocrine Sweat Gland Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 362)
# Related Disease Score Top Affiliating Genes
1 syringocystadenoma papilliferum 11.0
2 anus basaloid carcinoma 10.4 KRT7 CYLD
3 anal canal paget's disease 10.4 PIP KRT7
4 gastric signet ring cell adenocarcinoma 10.4 PIP KRT7
5 ureter squamous cell carcinoma 10.4 KRT7 KRT5
6 bartholin's gland carcinoma 10.4 PIP KRT7
7 inverted transitional papilloma 10.4 KRT7 KRT5
8 auditory system benign neoplasm 10.4 KRT7 KRT5
9 microinvasive cervical squamous cell carcinoma 10.4 KRT7 KRT5
10 eyelid carcinoma 10.4 PIP KRT7
11 stomach carcinoma in situ 10.4 KRT5 CYLD
12 leukoplakia of penis 10.4 KRT7 CEACAM5
13 lung clear cell carcinoma 10.4 KRT7 KRT5
14 erysipeloid 10.4 PIP KRT7
15 necrotizing sialometaplasia 10.4 KRT7 KRT5
16 sensory organ benign neoplasm 10.4 KRT7 KRT5
17 breast secretory carcinoma 10.4 PIP KRT5
18 fox-fordyce disease 10.4 PIP CEACAM5
19 gastric squamous cell carcinoma 10.4 KRT7 KRT5
20 vulvar eccrine porocarcinoma 10.4 PIP CEACAM5
21 mucoepidermoid esophageal carcinoma 10.4 KRT5 CEACAM5
22 pancreatic foamy gland adenocarcinoma 10.4 KRT7 CEACAM5
23 nodular hidradenoma 10.4 PIP CEACAM5
24 middle ear adenocarcinoma 10.4 KRT7 KRT5
25 balloon cell malignant melanoma 10.4 KRT7 KRT5
26 eccrine porocarcinoma 10.4 KRT7 CEACAM5
27 dacryocystocele 10.4 PIP KRT7
28 pancreatic serous cystadenocarcinoma 10.4 KRT7 CEACAM5
29 proliferating trichilemmal cyst 10.4 KRT8 KRT7
30 urinary bladder villous adenoma 10.4 KRT7 CEACAM5
31 chronic inflammation of lacrimal passage 10.4 PIP KRT7
32 endolymphatic sac tumor 10.4 KRT8 KRT7
33 gallbladder squamous cell carcinoma 10.4 KRT5 CEACAM5
34 vaginal tubulovillous adenoma 10.4 KRT7 CEACAM5
35 female urethral cancer 10.4 KRT7 CEACAM5
36 thymus adenocarcinoma 10.4 KRT5 CEACAM5
37 nephrogenic adenoma of the urethra 10.4 KRT7 KRT5
38 renal pelvis adenocarcinoma 10.4 KRT7 CEACAM5
39 bile duct cystadenocarcinoma 10.4 KRT7 CEACAM5
40 cystadenofibroma 10.4 KRT7 KRT5
41 tinea cruris 10.4 PIP KRT7
42 mucinous ovarian cystadenoma 10.4 KRT7 CEACAM5
43 rectosigmoid junction neoplasm 10.4 KRT7 CEACAM5
44 trachea carcinoma 10.4 KRT7 KRT5
45 transverse colon cancer 10.4 KRT7 CEACAM5
46 sigmoid neoplasm 10.4 KRT7 CEACAM5
47 mucinous stomach adenocarcinoma 10.4 KRT7 KRT5
48 krukenberg carcinoma 10.4 KRT7 CEACAM5
49 adenoid basal cell carcinoma 10.3 KRT7 CEACAM5
50 appendiceal neoplasm 10.3 KRT7 CEACAM5

Graphical network of the top 20 diseases related to Apocrine Sweat Gland Neoplasm:



Diseases related to Apocrine Sweat Gland Neoplasm

Symptoms & Phenotypes for Apocrine Sweat Gland Neoplasm

MGI Mouse Phenotypes related to Apocrine Sweat Gland Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.11 AR CYLD ERBB2 ESR1 FOXA1 KRT14
2 homeostasis/metabolism MP:0005376 10.03 ALPK1 AR CYLD ERBB2 ESR1 FOXA1
3 endocrine/exocrine gland MP:0005379 9.97 AR CYLD ERBB2 ESR1 FOXA1 KRT14
4 integument MP:0010771 9.81 AR CYLD ERBB2 ESR1 FOXA1 KRT14
5 limbs/digits/tail MP:0005371 9.5 AR CYLD ERBB2 ESR1 KRT5 PGR
6 neoplasm MP:0002006 9.23 AR CYLD ERBB2 ESR1 FOXA1 KRT14

Drugs & Therapeutics for Apocrine Sweat Gland Neoplasm

Search Clinical Trials , NIH Clinical Center for Apocrine Sweat Gland Neoplasm

Genetic Tests for Apocrine Sweat Gland Neoplasm

Anatomical Context for Apocrine Sweat Gland Neoplasm

MalaCards organs/tissues related to Apocrine Sweat Gland Neoplasm:

40
Breast, Skin, Liver, Lung, Ovary, Prostate, Appendix

Publications for Apocrine Sweat Gland Neoplasm

Articles related to Apocrine Sweat Gland Neoplasm:

# Title Authors PMID Year
1
Primary adenomyoepithelioma of the skin - a variant of apocrine mixed tumor? 61
24765550 2012
2
Unusual anogenital apocrine tumor resembling mammary-like gland adenoma in male perineum: a case report. 61
20576161 2010
3
Microcystic adnexal carcinoma: an often misdiagnosed, locally aggressive growing skin tumor. 61
15699645 2005
4
Circulating antibodies against the breast tumor marker GCDFP-15/gp17 in mammary carcinoma patients and in patients carrying benign breast conditions. 61
10567900 1999
5
Apocrine adenocarcinoma arising in Moll gland cystadenoma. 61
8233400 1993
6
An apocrine tumor of the groin. 61
213461 1978
7
Bronchiolar apocrine tumor. 61
4287458 1966

Variations for Apocrine Sweat Gland Neoplasm

Expression for Apocrine Sweat Gland Neoplasm

Search GEO for disease gene expression data for Apocrine Sweat Gland Neoplasm.

Pathways for Apocrine Sweat Gland Neoplasm

Pathways related to Apocrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.81 KRT8 KRT7 KRT5 KRT15 KRT14
2 11.6 PGR KRT15 KRT14 ESR1
3
Show member pathways
11.58 PGR ESR1 ERBB2
4
Show member pathways
11.45 PGR ESR1 AR
5
Show member pathways
11.1 FOXA1 ESR1 AR
6
Show member pathways
10.96 KRT8 KRT7 KRT5 KRT14

GO Terms for Apocrine Sweat Gland Neoplasm

Cellular components related to Apocrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 10 PGR KRT8 KRT7 KRT5 KRT15 KRT14
2 nucleus GO:0005634 9.97 ZNF528 SOX10 PIP PGR KRT8 KRT7
3 keratin filament GO:0045095 9.26 KRT8 KRT7 KRT5 KRT14
4 intermediate filament GO:0005882 9.02 KRT8 KRT7 KRT5 KRT15 KRT14

Biological processes related to Apocrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 9.98 ZNF528 SOX10 PGR FOXA1 ESR1 ERBB2
2 epidermis development GO:0008544 9.63 KRT5 KRT15 KRT14
3 keratinization GO:0031424 9.55 KRT8 KRT7 KRT5 KRT15 KRT14
4 intracellular estrogen receptor signaling pathway GO:0030520 9.51 ESR1 AR
5 cellular response to estrogen stimulus GO:0071391 9.49 ESR1 AR
6 mammary gland alveolus development GO:0060749 9.48 ESR1 AR
7 positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 9.4 FOXA1 AR
8 hemidesmosome assembly GO:0031581 9.37 KRT5 KRT14
9 prostate gland epithelium morphogenesis GO:0060740 9.32 FOXA1 AR
10 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 9.26 PGR AR
11 intracellular steroid hormone receptor signaling pathway GO:0030518 9.13 PGR ESR1 AR
12 cornification GO:0070268 9.02 KRT8 KRT7 KRT5 KRT15 KRT14

Molecular functions related to Apocrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.97 ZNF528 SOX10 PGR FOXA1 ESR1 AR
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.95 ZNF528 SOX10 PGR FOXA1 ESR1 AR
3 DNA-binding transcription factor activity GO:0003700 9.83 SOX10 PGR FOXA1 ESR1 AR
4 transcription factor binding GO:0008134 9.76 SOX10 FOXA1 ESR1 AR
5 structural constituent of cytoskeleton GO:0005200 9.58 KRT5 KRT15 KRT14
6 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.55 SOX10 PGR FOXA1 ESR1 AR
7 ATPase binding GO:0051117 9.54 PGR ESR1 AR
8 scaffold protein binding GO:0097110 9.43 KRT8 KRT5 KRT15
9 RNA polymerase II transcription coactivator binding GO:0001225 9.32 PGR AR
10 nuclear receptor activity GO:0004879 9.13 PGR ESR1 AR
11 steroid binding GO:0005496 8.8 PGR ESR1 AR

Sources for Apocrine Sweat Gland Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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