MCID: APP003
MIFTS: 40

Appendiceal Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Appendiceal Neoplasm

MalaCards integrated aliases for Appendiceal Neoplasm:

Name: Appendiceal Neoplasm 12 15 17
Appendiceal Neoplasms 56
Neoplasm of Appendix 12
Appendix Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11240
MeSH 45 D001063
NCIt 51 C4434
UMLS 74 C0003614

Summaries for Appendiceal Neoplasm

MalaCards based summary : Appendiceal Neoplasm, also known as appendiceal neoplasms, is related to appendix cancer and mucinous adenocarcinoma. An important gene associated with Appendiceal Neoplasm is YARS (Tyrosyl-TRNA Synthetase), and among its related pathways/superpathways are Colorectal Cancer Metastasis and Integrated Breast Cancer Pathway. The drugs Fluorouracil and Levoleucovorin have been mentioned in the context of this disorder. Affiliated tissues include appendix, lung and breast.

Related Diseases for Appendiceal Neoplasm

Diseases related to Appendiceal Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 220)
# Related Disease Score Top Affiliating Genes
1 appendix cancer 31.4 KRT20 KRT7 MUC1 MUC6 RHCE TP53
2 mucinous adenocarcinoma 30.1 KRT20 KRT7 MUC1
3 cystadenocarcinoma 29.9 KRT7 MUC1 TP53
4 pseudomyxoma peritonei 29.7 KRT20 KRT7 MUC1 MUC6 TP53
5 adenocarcinoma 29.7 CDH1 CTNNB1 MUC1 TP53
6 cystadenoma 29.6 KRT20 KRT7 MUC1 MUC6
7 colorectal cancer 28.0 CDH1 CTNNB1 KRT20 KRT7 MUC1 MUC6
8 jejunal adenocarcinoma 10.4 KRT20 KRT7
9 immune system organ benign neoplasm 10.4 KRT20 KRT7
10 bladder lymphoma 10.4 KRT20 KRT7
11 chronic cystitis 10.4 KRT20 KRT7
12 thymus lipoma 10.4 KRT20 KRT7
13 rectum adenocarcinoma 10.4 KRT20 KRT7
14 vulval paget's disease 10.4 KRT20 KRT7
15 vulva adenocarcinoma 10.4 KRT20 KRT7
16 prostatic acinar adenocarcinoma 10.4 KRT20 KRT7
17 ovarian mucinous adenocarcinoma 10.4 KRT20 KRT7
18 medulloepithelioma 10.4 KRT20 KRT7
19 renal pelvis carcinoma 10.4 KRT20 KRT7
20 thymus adenocarcinoma 10.4 KRT20 KRT7
21 ovarian cystic teratoma 10.4 KRT20 KRT7
22 meningeal melanocytoma 10.4 MUC1 YARS
23 meibomian cyst 10.4 KRT20 KRT7
24 horseshoe kidney 10.4 KRT20 KRT7
25 brachydactyly, type e1 10.4 KRT20 MUC1
26 villous adenoma 10.4 KRT20 MUC1
27 dendritic cell tumor 10.4 KRT20 MUC1
28 sertoli-leydig cell tumor 10.4 KRT7 MUC1
29 mucinous ovarian cystadenoma 10.4 KRT7 MUC1
30 spindle cell sarcoma 10.4 KRT7 MUC1
31 lipoadenoma 10.4 KRT7 MUC1
32 monophasic synovial sarcoma 10.4 KRT7 MUC1
33 well-differentiated liposarcoma 10.4 KRT7 MUC1
34 morpheaform basal cell carcinoma 10.3 CDH1 KRT20
35 pulmonary sclerosing hemangioma 10.3 CTNNB1 KRT7
36 cystic basal cell carcinoma 10.3 KRT20 KRT7
37 breast adenomyoepithelioma 10.3 CDH1 KRT7
38 breast myoepithelial neoplasm 10.3 CDH1 KRT7
39 seminal vesicle adenocarcinoma 10.3 KRT20 KRT7
40 transverse colon cancer 10.3 KRT20 KRT7
41 gelatinous ascites 10.3
42 malignant syringoma 10.3 KRT20 KRT7
43 chondroid chordoma 10.3 CDH1 MUC1
44 biphasic synovial sarcoma 10.3 CDH1 MUC1
45 gastric cardia carcinoma 10.3 CDH1 MUC1
46 glandular cystitis 10.3 KRT20 KRT7
47 papillary transitional carcinoma 10.3 KRT20 KRT7
48 eyelid carcinoma 10.3 KRT20 KRT7
49 prostate squamous cell carcinoma 10.3 KRT7 TP53
50 necrotizing sialometaplasia 10.3 KRT7 TP53

Graphical network of the top 20 diseases related to Appendiceal Neoplasm:



Diseases related to Appendiceal Neoplasm

Symptoms & Phenotypes for Appendiceal Neoplasm

Drugs & Therapeutics for Appendiceal Neoplasm

Drugs for Appendiceal Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 81)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 2,Phase 1 51-21-8 3385
2
Levoleucovorin Approved, Investigational Phase 2,Phase 1 68538-85-2
3
leucovorin Approved Phase 2,Phase 1 58-05-9 6006 143
4
Oxaliplatin Approved, Investigational Phase 2,Phase 1 61825-94-3 6857599 5310940 9887054 43805
5
Irinotecan Approved, Investigational Phase 2,Phase 1 100286-90-6, 97682-44-5 60838
6
Floxuridine Approved Phase 2 50-91-9 5790
7
carbamide peroxide Approved Phase 2 124-43-6
8
Lansoprazole Approved, Investigational Phase 2 103577-45-3 3883
9
Amoxicillin Approved, Vet_approved Phase 2 26787-78-0 33613
10
Clarithromycin Approved Phase 2 81103-11-9 84029
11
Dexlansoprazole Approved, Investigational Phase 2 138530-94-6, 103577-45-3 9578005
12
Nintedanib Approved Phase 2 656247-17-5 56843413
13
Durvalumab Approved, Investigational Phase 1, Phase 2 1428935-60-7
14
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 6055-19-2, 50-18-0 2907
15
Melphalan Approved Phase 2 148-82-3 460612 4053
16
nivolumab Approved Phase 2 946414-94-4
17
Ipilimumab Approved Phase 2 477202-00-9
18
Palonosetron Approved, Investigational Phase 2 135729-61-2, 119904-90-4, 135729-56-5 148211
19
Calcium Approved, Nutraceutical Phase 2,Phase 1 7440-70-2 271
20 Cola Phase 2,Phase 1
21 Anti-Bacterial Agents Phase 2
22 Antidotes Phase 2,Phase 1
23 Antimetabolites Phase 2,Phase 1
24 Immunosuppressive Agents Phase 2,Phase 1
25 Mitomycins Phase 2
26 Antimetabolites, Antineoplastic Phase 2,Phase 1
27 Immunologic Factors Phase 2,Phase 1
28 Nucleic Acid Synthesis Inhibitors Phase 2
29 Alkylating Agents Phase 2
30 Antibiotics, Antitubercular Phase 2
31 Calcium, Dietary Phase 2,Phase 1
32 Protective Agents Phase 2,Phase 1
33 Angiogenesis Modulating Agents Phase 2,Phase 1
34 Angiogenesis Inhibitors Phase 2,Phase 1
35 Anti-Infective Agents Phase 2
36 Antibodies Phase 1, Phase 2
37 Antibodies, Monoclonal Phase 1, Phase 2
38 Antineoplastic Agents, Immunological Phase 1, Phase 2,Phase 2
39 Immunoglobulins Phase 1, Phase 2
40 Topoisomerase Inhibitors Phase 2,Phase 1
41 topoisomerase I inhibitors Phase 2,Phase 1
42 Liver Extracts Phase 2,Phase 1
43 Cytochrome P-450 CYP3A Inhibitors Phase 2
44 Cytochrome P-450 Enzyme Inhibitors Phase 2
45 Anti-Ulcer Agents Phase 2
46 Gastrointestinal Agents Phase 2
47 Proton Pump Inhibitors Phase 2
48 Antacids Phase 2
49 Antitubercular Agents Phase 2
50 Antineoplastic Agents, Alkylating Phase 2

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 Fluorouracil With or Without Mitomycin in Treating Patients With Peritoneal Cancer Unknown status NCT00006112 Phase 2 chemotherapy;fluorouracil;leucovorin calcium;mitomycin C
2 Surgery and Oxaliplatin or Mitomycin C in Treating Patients With Tumors of the Appendix Completed NCT01580410 Phase 2 mitomycin C;oxaliplatin;hyperthermic intraperitoneal chemotherapy
3 Thalidomide in Treating Patients Who Have Undergone Surgery and Chemotherapy for Cancer That Has Spread Throughout the Abdomen Due to Colorectal Cancer or Appendix Cancer Completed NCT00310076 Phase 2 thalidomide
4 ICARuS Post-operative Intraperitoneal Chemotherapy (EPIC) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) After Optimal Cytoreductive Surgery (CRS) for Neoplasms of the Appendix, Colon or Rectum With Isolated Peritoneal Metastasis Recruiting NCT01815359 Phase 2 HIPEC with Mitomycin-C;EPIC with FUDR and Leucovorin
5 Antibiotic Treatment and Long-term Outcomes of Patients With Pseudomyxoma Peritonei of Appendiceal Origin Recruiting NCT02387203 Phase 2 PrevPac (Prevacid, Amoxicillin, Clarithromycin)
6 PIPAC for Peritoneal Metastases of Colorectal Cancer Recruiting NCT03246321 Phase 2
7 LCI-GI-APX-NIN-001: Nintedanib in Metastatic Appendiceal Carcinoma Recruiting NCT03287947 Phase 2 nintedanib
8 A Phase 1/2 Study to Investigate the Safety, Biologic and Anti-tumor Activity of ONCOS-102 in Combination With Durvalumab in Subjects With Advanced Peritoneal Malignancies Recruiting NCT02963831 Phase 1, Phase 2 Durvalumab
9 Comparing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) Using Mitomycin-C Versus Melphalan for Colorectal Peritoneal Carcinomatosis Recruiting NCT03073694 Phase 2 Mitomycin c;Melphalan
10 Single Arm Study Treating Patients of Peritoneal Surface Malignancy (Colorectal, Appendical, Pseudomyxoma, Gastric) With Cytoreductive Surgery and Hyperthermic Intraperitoneal Mitomycin-C Enrolling by invitation NCT02040142 Phase 2 Mitomycin C
11 Nivolumab and Ipilimumab in Mucinous Colorectal and Appendiceal Tumors Not yet recruiting NCT03693846 Phase 2 Nivolumab;Ipilimumab
12 Treatment of a Cancerous Disease of the Peritoneum With Complete Cytoreductive Surgery and Intraperitoneal Chemohyperthermia Terminated NCT00180960 Phase 2 Oxaliplatin and irinotecan
13 Palonosetron Hydrochloride in Preventing Nausea and Vomiting Caused by Radiation Therapy in Patients With Primary Abdominal Cancer Terminated NCT00903396 Phase 2 palonosetron hydrochloride
14 Oxaliplatin Plus Capecitabine in Treating Patients With Colorectal, Appendix, or Small Bowel Cancer Completed NCT00019773 Phase 1 capecitabine;oxaliplatin
15 Intraperitoneal Hyperthermic Perfusion With Oxaliplatin in Treating Patients With Stage IV Peritoneal Cancer Due to Appendix Cancer or Colorectal Cancer Completed NCT00458809 Phase 1 oxaliplatin
16 Irinotecan, Fluorouracil, and Leucovorin in Treating Patients With Advanced Gastrointestinal Cancer Completed NCT00654160 Phase 1 fluorouracil;irinotecan hydrochloride;leucovorin calcium
17 Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer Completed NCT00397384 Phase 1 cetuximab;erlotinib hydrochloride
18 Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu Completed NCT00004074 Phase 1
19 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007) Completed NCT00031681 Phase 1 7-hydroxystaurosporine;irinotecan hydrochloride
20 Trial of Intraperitoneal (IP) Oxaliplatin in Combination With Intravenous FOLFIRI Recruiting NCT02833753 Phase 1 Oxaliplatin
21 Low vs. Standard Dose CT for Appendicitis Trial Completed NCT01925014 Not Applicable
22 Knowledge, Attitudes, and Practice of Surgeons Toward Nutrition Support in HIPEC Patients Completed NCT02374411
23 Quality of Life and Survivorship Care in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Completed NCT01126346 Not Applicable
24 Gastrointestinal Microbiome Study of Appendiceal Cancer Recruiting NCT02599116 Not Applicable
25 Selective Rather Than Routine Histopathological Examination After Appendectomy and Cholecystectomy Recruiting NCT03510923
26 Trial of Cytoreductive Surgery and HIPEC in Patients With Primary and Secondary Peritoneal Cancers Recruiting NCT03604653 Mitomycin c;CDDP;CDDP;Doxorubicin
27 International Registry of Patients Treated With Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) Recruiting NCT03210298
28 Distant Metastases and Long-Term Survival After Complete Resection of Neuroendocrine Tumors of the Appendix Not yet recruiting NCT03852693
29 EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung Cancer Terminated NCT00087191 Not Applicable EF5;motexafin lutetium

Search NIH Clinical Center for Appendiceal Neoplasm

Genetic Tests for Appendiceal Neoplasm

Anatomical Context for Appendiceal Neoplasm

MalaCards organs/tissues related to Appendiceal Neoplasm:

42
Appendix, Lung, Breast, Colon, Liver

Publications for Appendiceal Neoplasm

Articles related to Appendiceal Neoplasm:

(show all 47)
# Title Authors Year
1
Mucinous appendiceal neoplasms: classification, imaging, and HIPEC. ( 30610247 )
2019
2
Psoas/iliacus muscle invasion from mucinous appendiceal neoplasm. Radiologic appearance and outcome of treatment in 3 patients. ( 29937165 )
2018
3
Appendiceal neoplasm risk associated with complicated acute appendicitis-a population based study. ( 30242478 )
2018
4
Risk of Appendiceal Neoplasm in Periappendicular Abscess in Patients Treated With Interval Appendectomy vs Follow-up With Magnetic Resonance Imaging: 1-year Outcomes of the Peri-Appendicitis Acuta Randomized Clinical Trial. ( 30484824 )
2018
5
Review: Pathology and Its Clinical Relevance of Mucinous Appendiceal Neoplasms and Pseudomyxoma Peritonei. ( 30611664 )
2018
6
Diagnostic and therapeutic laparoscopy in assessment and management of patients with appendiceal neoplasms. ( 28605985 )
2018
7
Correction to: Tan et al., Diagnostic and therapeutic laparoscopy in assessment and management of patients with appendiceal neoplasms. ( 28967270 )
2018
8
Mucinous appendiceal neoplasms: pathologic classification, clinical implications, imaging spectrum and mimics. ( 29564494 )
2018
9
Single-center analysis of appendiceal neoplasms. ( 29731850 )
2018
10
Appendiceal Neoplasms. ( 30186049 )
2018
11
Appendiceal neoplasm presenting as intussusception in an adult - a video vignette. ( 28235158 )
2017
12
Occult Appendiceal Neoplasms in Acute and Chronic Appendicitis: A Single-Institution Experience of 1793 Appendectomies. ( 29336758 )
2017
13
When and When Not to Perform a Right Colon Resection with Mucinous Appendiceal Neoplasms. ( 27770344 )
2017
14
Radical appendectomy as an alternative to right colon resection in patients with epithelial appendiceal neoplasms. ( 28317590 )
2017
15
Mucinous appendiceal neoplasms: Incidence, diagnosis and surgical treatment. ( 28655402 )
2017
16
Two concurrent appendiceal neoplasms in an elderly patient: A case report. ( 28988021 )
2017
17
Appendiceal Neoplasms. ( 29112557 )
2017
18
Expert Commentary on Appendiceal Neoplasms. ( 29112558 )
2017
19
Corrigendum to "Diagnosis and Treatment of Mucinous Appendiceal Neoplasm Presented as Acute Appendicitis". ( 27957365 )
2016
20
Diagnosis and Treatment of Mucinous Appendiceal Neoplasm Presented as Acute Appendicitis. ( 27066284 )
2016
21
Ileocecal Intussusception Caused by an Appendiceal Neoplasm. ( 26831058 )
2016
22
Outcomes of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemoperfusion in Patients with High-Grade, High-Volume Disseminated Mucinous Appendiceal Neoplasms. ( 26429720 )
2016
23
Prophylactic hyperthermic intraperitoneal chemotherapy in patients with epithelial appendiceal neoplasms. ( 27050712 )
2016
24
Guidelines on the use of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with peritoneal surface malignancy arising from colorectal or appendiceal neoplasms. ( 25908915 )
2015
25
Evaluation of a new staging classification and a Peritoneal Surface Disease Severity Score (PSDSS) in 229 patients with mucinous appendiceal neoplasms with or without peritoneal dissemination. ( 24898451 )
2014
26
Does obesity affect outcomes of cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion for disseminated mucinous appendiceal neoplasms? ( 24916747 )
2014
27
Low-grade appendiceal neoplasm presenting as a volvulus of the cecum. ( 24759968 )
2013
28
Pulmonary metastasis from a low grade mucinous appendiceal neoplasm. ( 23250037 )
2013
29
Delay of cytoreductive surgery and heated intraperitoneal chemotherapy in patients with appendiceal neoplasm. ( 22748531 )
2012
30
Mucinous appendiceal neoplasms. Do we all speak the same language? ( 22300121 )
2012
31
Aggressive management of peritoneal carcinomatosis from mucinous appendiceal neoplasms. ( 22302270 )
2012
32
Inflammatory markers in blood and serum tumor markers predict survival in patients with epithelial appendiceal neoplasms undergoing surgical cytoreduction and intraperitoneal chemotherapy. ( 22750758 )
2012
33
Is malignant dedifferentiation for mucinous appendiceal neoplasms a valid phenomenon or merely histopathologic ambiguity? ( 21530846 )
2011
34
How should we treat mucinous appendiceal neoplasm? By laparoscopy or laparotomy? A case report. ( 20514834 )
2010
35
Significant association of appendiceal neoplasms and ulcerative colitis rather than Crohn's disease. ( 19705419 )
2010
36
Clinicopathological analysis of primary epithelial appendiceal neoplasms. ( 19851895 )
2010
37
Incidence of synchronous appendiceal neoplasm in patients with colorectal cancer and its clinical significance. ( 19490638 )
2009
38
Epithelial appendiceal neoplasms. ( 19556909 )
2009
39
Diverticular disease of the vermiform appendix: a diagnostic clue to underlying appendiceal neoplasm. ( 18715614 )
2008
40
Mucinous appendiceal neoplasms: preoperative MR staging and classification compared with surgical and histopathologic findings. ( 18287436 )
2008
41
The porta hepatis as a site of recurrence of mucinous appendiceal neoplasms treated by cytoreductive surgery and perioperative intraperitoneal chemotherapy. ( 19112943 )
2008
42
Early results of surgery in 123 patients with pseudomyxoma peritonei from a perforated appendiceal neoplasm. ( 17115339 )
2007
43
Management of an unexpected appendiceal neoplasm. ( 16775823 )
2006
44
Appendiceal neoplasms with peritoneal dissemination: outcomes after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy. ( 16538401 )
2006
45
The "alphabet soup" of peritoneal dissemination from appendiceal neoplasms and other malignancies. ( 16538404 )
2006
46
Primary appendiceal neoplasms. ( 8270409 )
1993
47
Adenocarcinoma of the colon associated with benign appendiceal neoplasm. ( 7089665 )
1982

Variations for Appendiceal Neoplasm

Expression for Appendiceal Neoplasm

Search GEO for disease gene expression data for Appendiceal Neoplasm.

Pathways for Appendiceal Neoplasm

Pathways related to Appendiceal Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.72 CDH1 CTNNB1 TP53
2 11.62 CDH1 CTNNB1 TP53
3 11.42 CDH1 CTNNB1 MUC1
4 11.41 CDH1 KRT20 KRT7 MUC1
5 10.77 CDH1 CTNNB1
6 10.07 CDH1 CTNNB1

GO Terms for Appendiceal Neoplasm

Cellular components related to Appendiceal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 catenin complex GO:0016342 9.16 CDH1 CTNNB1
2 apical junction complex GO:0043296 8.96 CDH1 CTNNB1
3 flotillin complex GO:0016600 8.62 CDH1 CTNNB1

Biological processes related to Appendiceal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to gamma radiation GO:0010332 9.26 POLB TP53
2 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.16 MUC1 TP53
3 entry of bacterium into host cell GO:0035635 8.96 CDH1 CTNNB1
4 cellular response to indole-3-methanol GO:0071681 8.62 CDH1 CTNNB1

Sources for Appendiceal Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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