Appendiceal Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: APP003 MIFTS: 40	Appendiceal Neoplasm Categories: Cancer diseases, Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Appendiceal Neoplasm

MalaCards integrated aliases for Appendiceal Neoplasm:

Name: Appendiceal Neoplasm ¹² ¹⁵ ¹⁷

Appendiceal Neoplasms ⁵⁶

Neoplasm of Appendix ¹²

Appendix Neoplasm ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:11240

MeSH ⁴⁵ D001063

NCIt ⁵¹ C4434

EFO ¹⁷ EFO_0003880

UMLS ⁷⁴ C0003614

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Summaries for Appendiceal Neoplasm

MalaCards based summary : Appendiceal Neoplasm, also known as appendiceal neoplasms, is related to appendix cancer and mucinous adenocarcinoma. An important gene associated with Appendiceal Neoplasm is YARS (Tyrosyl-TRNA Synthetase), and among its related pathways/superpathways are Colorectal Cancer Metastasis and Integrated Breast Cancer Pathway. The drugs Fluorouracil and Levoleucovorin have been mentioned in the context of this disorder. Affiliated tissues include appendix, lung and breast.

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Related Diseases for Appendiceal Neoplasm

Diseases related to Appendiceal Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 220)

#	Related Disease	Score	Top Affiliating Genes
1	appendix cancer	31.4	KRT20 KRT7 MUC1 MUC6 RHCE TP53
2	mucinous adenocarcinoma	30.1	KRT20 KRT7 MUC1
3	cystadenocarcinoma	29.9	KRT7 MUC1 TP53
4	pseudomyxoma peritonei	29.7	KRT20 KRT7 MUC1 MUC6 TP53
5	adenocarcinoma	29.7	CDH1 CTNNB1 MUC1 TP53
6	cystadenoma	29.6	KRT20 KRT7 MUC1 MUC6
7	colorectal cancer	28.0	CDH1 CTNNB1 KRT20 KRT7 MUC1 MUC6
8	jejunal adenocarcinoma	10.4	KRT20 KRT7
9	immune system organ benign neoplasm	10.4	KRT20 KRT7
10	bladder lymphoma	10.4	KRT20 KRT7
11	chronic cystitis	10.4	KRT20 KRT7
12	thymus lipoma	10.4	KRT20 KRT7
13	rectum adenocarcinoma	10.4	KRT20 KRT7
14	vulval paget's disease	10.4	KRT20 KRT7
15	vulva adenocarcinoma	10.4	KRT20 KRT7
16	prostatic acinar adenocarcinoma	10.4	KRT20 KRT7
17	ovarian mucinous adenocarcinoma	10.4	KRT20 KRT7
18	medulloepithelioma	10.4	KRT20 KRT7
19	renal pelvis carcinoma	10.4	KRT20 KRT7
20	thymus adenocarcinoma	10.4	KRT20 KRT7
21	ovarian cystic teratoma	10.4	KRT20 KRT7
22	meningeal melanocytoma	10.4	MUC1 YARS
23	meibomian cyst	10.4	KRT20 KRT7
24	horseshoe kidney	10.4	KRT20 KRT7
25	brachydactyly, type e1	10.4	KRT20 MUC1
26	villous adenoma	10.4	KRT20 MUC1
27	dendritic cell tumor	10.4	KRT20 MUC1
28	sertoli-leydig cell tumor	10.4	KRT7 MUC1
29	mucinous ovarian cystadenoma	10.4	KRT7 MUC1
30	spindle cell sarcoma	10.4	KRT7 MUC1
31	lipoadenoma	10.4	KRT7 MUC1
32	monophasic synovial sarcoma	10.4	KRT7 MUC1
33	well-differentiated liposarcoma	10.4	KRT7 MUC1
34	morpheaform basal cell carcinoma	10.3	CDH1 KRT20
35	pulmonary sclerosing hemangioma	10.3	CTNNB1 KRT7
36	cystic basal cell carcinoma	10.3	KRT20 KRT7
37	breast adenomyoepithelioma	10.3	CDH1 KRT7
38	breast myoepithelial neoplasm	10.3	CDH1 KRT7
39	seminal vesicle adenocarcinoma	10.3	KRT20 KRT7
40	transverse colon cancer	10.3	KRT20 KRT7
41	gelatinous ascites	10.3
42	malignant syringoma	10.3	KRT20 KRT7
43	chondroid chordoma	10.3	CDH1 MUC1
44	biphasic synovial sarcoma	10.3	CDH1 MUC1
45	gastric cardia carcinoma	10.3	CDH1 MUC1
46	glandular cystitis	10.3	KRT20 KRT7
47	papillary transitional carcinoma	10.3	KRT20 KRT7
48	eyelid carcinoma	10.3	KRT20 KRT7
49	prostate squamous cell carcinoma	10.3	KRT7 TP53
50	necrotizing sialometaplasia	10.3	KRT7 TP53

Graphical network of the top 20 diseases related to Appendiceal Neoplasm:

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Symptoms & Phenotypes for Appendiceal Neoplasm

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Drugs & Therapeutics for Appendiceal Neoplasm

Drugs for Appendiceal Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 81)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Fluorouracil

Approved

Phase 2,Phase 1

51-21-8

3385

Levoleucovorin

Approved, Investigational

Phase 2,Phase 1

68538-85-2

leucovorin

Approved

Phase 2,Phase 1

58-05-9

6006 143

Oxaliplatin

Approved, Investigational

Phase 2,Phase 1

61825-94-3

6857599 5310940 9887054 43805

Irinotecan

Approved, Investigational

Phase 2,Phase 1

100286-90-6, 97682-44-5

60838

Floxuridine

Approved

Phase 2

50-91-9

5790

carbamide peroxide

Approved

Phase 2

124-43-6

Lansoprazole

Approved, Investigational

Phase 2

103577-45-3

3883

Amoxicillin

Approved, Vet_approved

Phase 2

26787-78-0

33613

Clarithromycin

Approved

Phase 2

81103-11-9

84029

Dexlansoprazole

Approved, Investigational

Phase 2

138530-94-6, 103577-45-3

9578005

Nintedanib

Approved

Phase 2

656247-17-5

56843413

Durvalumab

Approved, Investigational

Phase 1, Phase 2

1428935-60-7

Cyclophosphamide

Approved, Investigational

Phase 1, Phase 2

6055-19-2, 50-18-0

2907

Melphalan

Approved

Phase 2

148-82-3

460612 4053

nivolumab

Approved

Phase 2

946414-94-4

Ipilimumab

Approved

Phase 2

477202-00-9

Palonosetron

Approved, Investigational

Phase 2

135729-61-2, 119904-90-4, 135729-56-5

148211

Calcium

Approved, Nutraceutical

Phase 2,Phase 1

7440-70-2

271

Cola

Phase 2,Phase 1

Anti-Bacterial Agents

Phase 2

Antidotes

Phase 2,Phase 1

Antimetabolites

Phase 2,Phase 1

Immunosuppressive Agents

Phase 2,Phase 1

Mitomycins

Phase 2

Antimetabolites, Antineoplastic

Phase 2,Phase 1

Immunologic Factors

Phase 2,Phase 1

Nucleic Acid Synthesis Inhibitors

Phase 2

Alkylating Agents

Phase 2

Antibiotics, Antitubercular

Phase 2

Calcium, Dietary

Phase 2,Phase 1

Protective Agents

Phase 2,Phase 1

Angiogenesis Modulating Agents

Phase 2,Phase 1

Angiogenesis Inhibitors

Phase 2,Phase 1

Anti-Infective Agents

Phase 2

Antibodies

Phase 1, Phase 2

Antibodies, Monoclonal

Phase 1, Phase 2

Antineoplastic Agents, Immunological

Phase 1, Phase 2,Phase 2

Immunoglobulins

Phase 1, Phase 2

Topoisomerase Inhibitors

Phase 2,Phase 1

topoisomerase I inhibitors

Phase 2,Phase 1

Liver Extracts

Phase 2,Phase 1

Cytochrome P-450 CYP3A Inhibitors

Phase 2

Cytochrome P-450 Enzyme Inhibitors

Phase 2

Anti-Ulcer Agents

Phase 2

Gastrointestinal Agents

Phase 2

Proton Pump Inhibitors

Phase 2

Antacids

Phase 2

Antitubercular Agents

Phase 2

Antineoplastic Agents, Alkylating

Phase 2

Interventional clinical trials:

(show all 29)

#	Name	Status	NCT ID	Phase	Drugs
1	Fluorouracil With or Without Mitomycin in Treating Patients With Peritoneal Cancer	Unknown status	NCT00006112	Phase 2	chemotherapy;fluorouracil;leucovorin calcium;mitomycin C
2	Surgery and Oxaliplatin or Mitomycin C in Treating Patients With Tumors of the Appendix	Completed	NCT01580410	Phase 2	mitomycin C;oxaliplatin;hyperthermic intraperitoneal chemotherapy
3	Thalidomide in Treating Patients Who Have Undergone Surgery and Chemotherapy for Cancer That Has Spread Throughout the Abdomen Due to Colorectal Cancer or Appendix Cancer	Completed	NCT00310076	Phase 2	thalidomide
4	ICARuS Post-operative Intraperitoneal Chemotherapy (EPIC) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) After Optimal Cytoreductive Surgery (CRS) for Neoplasms of the Appendix, Colon or Rectum With Isolated Peritoneal Metastasis	Recruiting	NCT01815359	Phase 2	HIPEC with Mitomycin-C;EPIC with FUDR and Leucovorin
5	Antibiotic Treatment and Long-term Outcomes of Patients With Pseudomyxoma Peritonei of Appendiceal Origin	Recruiting	NCT02387203	Phase 2	PrevPac (Prevacid, Amoxicillin, Clarithromycin)
6	PIPAC for Peritoneal Metastases of Colorectal Cancer	Recruiting	NCT03246321	Phase 2
7	LCI-GI-APX-NIN-001: Nintedanib in Metastatic Appendiceal Carcinoma	Recruiting	NCT03287947	Phase 2	nintedanib
8	A Phase 1/2 Study to Investigate the Safety, Biologic and Anti-tumor Activity of ONCOS-102 in Combination With Durvalumab in Subjects With Advanced Peritoneal Malignancies	Recruiting	NCT02963831	Phase 1, Phase 2	Durvalumab
9	Comparing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) Using Mitomycin-C Versus Melphalan for Colorectal Peritoneal Carcinomatosis	Recruiting	NCT03073694	Phase 2	Mitomycin c;Melphalan
10	Single Arm Study Treating Patients of Peritoneal Surface Malignancy (Colorectal, Appendical, Pseudomyxoma, Gastric) With Cytoreductive Surgery and Hyperthermic Intraperitoneal Mitomycin-C	Enrolling by invitation	NCT02040142	Phase 2	Mitomycin C
11	Nivolumab and Ipilimumab in Mucinous Colorectal and Appendiceal Tumors	Not yet recruiting	NCT03693846	Phase 2	Nivolumab;Ipilimumab
12	Treatment of a Cancerous Disease of the Peritoneum With Complete Cytoreductive Surgery and Intraperitoneal Chemohyperthermia	Terminated	NCT00180960	Phase 2	Oxaliplatin and irinotecan
13	Palonosetron Hydrochloride in Preventing Nausea and Vomiting Caused by Radiation Therapy in Patients With Primary Abdominal Cancer	Terminated	NCT00903396	Phase 2	palonosetron hydrochloride
14	Oxaliplatin Plus Capecitabine in Treating Patients With Colorectal, Appendix, or Small Bowel Cancer	Completed	NCT00019773	Phase 1	capecitabine;oxaliplatin
15	Intraperitoneal Hyperthermic Perfusion With Oxaliplatin in Treating Patients With Stage IV Peritoneal Cancer Due to Appendix Cancer or Colorectal Cancer	Completed	NCT00458809	Phase 1	oxaliplatin
16	Irinotecan, Fluorouracil, and Leucovorin in Treating Patients With Advanced Gastrointestinal Cancer	Completed	NCT00654160	Phase 1	fluorouracil;irinotecan hydrochloride;leucovorin calcium
17	Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer	Completed	NCT00397384	Phase 1	cetuximab;erlotinib hydrochloride
18	Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu	Completed	NCT00004074	Phase 1
19	7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007)	Completed	NCT00031681	Phase 1	7-hydroxystaurosporine;irinotecan hydrochloride
20	Trial of Intraperitoneal (IP) Oxaliplatin in Combination With Intravenous FOLFIRI	Recruiting	NCT02833753	Phase 1	Oxaliplatin
21	Low vs. Standard Dose CT for Appendicitis Trial	Completed	NCT01925014	Not Applicable
22	Knowledge, Attitudes, and Practice of Surgeons Toward Nutrition Support in HIPEC Patients	Completed	NCT02374411
23	Quality of Life and Survivorship Care in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy (HIPEC)	Completed	NCT01126346	Not Applicable
24	Gastrointestinal Microbiome Study of Appendiceal Cancer	Recruiting	NCT02599116	Not Applicable
25	Selective Rather Than Routine Histopathological Examination After Appendectomy and Cholecystectomy	Recruiting	NCT03510923
26	Trial of Cytoreductive Surgery and HIPEC in Patients With Primary and Secondary Peritoneal Cancers	Recruiting	NCT03604653		Mitomycin c;CDDP;CDDP;Doxorubicin
27	International Registry of Patients Treated With Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC)	Recruiting	NCT03210298
28	Distant Metastases and Long-Term Survival After Complete Resection of Neuroendocrine Tumors of the Appendix	Not yet recruiting	NCT03852693
29	EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung Cancer	Terminated	NCT00087191	Not Applicable	EF5;motexafin lutetium

Search NIH Clinical Center for Appendiceal Neoplasm

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Genetic Tests for Appendiceal Neoplasm

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Anatomical Context for Appendiceal Neoplasm

MalaCards organs/tissues related to Appendiceal Neoplasm:

⁴²

Appendix, Lung, Breast, Colon, Liver

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Publications for Appendiceal Neoplasm

Articles related to Appendiceal Neoplasm:

(show all 47)

#	Title	Authors	Year
1	Mucinous appendiceal neoplasms: classification, imaging, and HIPEC. ( 30610247 )	Bartlett DJ...Sheedy SP	2019
2	Psoas/iliacus muscle invasion from mucinous appendiceal neoplasm. Radiologic appearance and outcome of treatment in 3 patients. ( 29937165 )	Sugarbaker PH	2018
3	Appendiceal neoplasm risk associated with complicated acute appendicitis-a population based study. ( 30242478 )	Lietz?n E...Salminen P	2018
4	Risk of Appendiceal Neoplasm in Periappendicular Abscess in Patients Treated With Interval Appendectomy vs Follow-up With Magnetic Resonance Imaging: 1-year Outcomes of the Peri-Appendicitis Acuta Randomized Clinical Trial. ( 30484824 )	M?llinen J...Salminen P	2018
5	Review: Pathology and Its Clinical Relevance of Mucinous Appendiceal Neoplasms and Pseudomyxoma Peritonei. ( 30611664 )	Legu? LM...Huysentruyt CJ	2018
6	Diagnostic and therapeutic laparoscopy in assessment and management of patients with appendiceal neoplasms. ( 28605985 )	Tan GHC...Moran BJ	2018
7	Correction to: Tan et al., Diagnostic and therapeutic laparoscopy in assessment and management of patients with appendiceal neoplasms. ( 28967270 )		2018
8	Mucinous appendiceal neoplasms: pathologic classification, clinical implications, imaging spectrum and mimics. ( 29564494 )	Van Hooser A...Myers DT	2018
9	Single-center analysis of appendiceal neoplasms. ( 29731850 )	Tajima T...Makuuchi H	2018
10	Appendiceal Neoplasms. ( 30186049 )	Hatch QM...Gilbert EW	2018
11	Appendiceal neoplasm presenting as intussusception in an adult - a video vignette. ( 28235158 )	Williamson JS...Swarnkar K	2017
12	Occult Appendiceal Neoplasms in Acute and Chronic Appendicitis: A Single-Institution Experience of 1793 Appendectomies. ( 29336758 )	Schwartz JA...Kim GJ	2017
13	When and When Not to Perform a Right Colon Resection with Mucinous Appendiceal Neoplasms. ( 27770344 )	Sugarbaker PH	2017
14	Radical appendectomy as an alternative to right colon resection in patients with epithelial appendiceal neoplasms. ( 28317590 )	Gonz?lez-Moreno S...Sugarbaker PH	2017
15	Mucinous appendiceal neoplasms: Incidence, diagnosis and surgical treatment. ( 28655402 )	Nutu OA...Jim?nez Romero LC	2017
16	Two concurrent appendiceal neoplasms in an elderly patient: A case report. ( 28988021 )	Das R...Vu TQ	2017
17	Appendiceal Neoplasms. ( 29112557 )	Hatch QM	2017
18	Expert Commentary on Appendiceal Neoplasms. ( 29112558 )	Votanopoulos KI	2017
19	Corrigendum to &quot;Diagnosis and Treatment of Mucinous Appendiceal Neoplasm Presented as Acute Appendicitis&quot;. ( 27957365 )	Kehagias I....Kraniotis P.	2016
20	Diagnosis and Treatment of Mucinous Appendiceal Neoplasm Presented as Acute Appendicitis. ( 27066284 )	Kehagias I....Kraniotis P.	2016
21	Ileocecal Intussusception Caused by an Appendiceal Neoplasm. ( 26831058 )	Chua T.C....Samra J.S.	2016
22	Outcomes of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemoperfusion in Patients with High-Grade, High-Volume Disseminated Mucinous Appendiceal Neoplasms. ( 26429720 )	Polanco PM...Choudry HA	2016
23	Prophylactic hyperthermic intraperitoneal chemotherapy in patients with epithelial appendiceal neoplasms. ( 27050712 )	Tuvin D...Sarpel U	2016
24	Guidelines on the use of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with peritoneal surface malignancy arising from colorectal or appendiceal neoplasms. ( 25908915 )	Dub? P...McCart JA	2015
25	Evaluation of a new staging classification and a Peritoneal Surface Disease Severity Score (PSDSS) in 229 patients with mucinous appendiceal neoplasms with or without peritoneal dissemination. ( 24898451 )	Esquivel J...Trout R	2014
26	Does obesity affect outcomes of cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion for disseminated mucinous appendiceal neoplasms? ( 24916747 )	Polanco PM...Choudry HA	2014
27	Low-grade appendiceal neoplasm presenting as a volvulus of the cecum. ( 24759968 )	Costa V....Demuro J.P.	2013
28	Pulmonary metastasis from a low grade mucinous appendiceal neoplasm. ( 23250037 )	Xu L....Burke A.	2013
29	Delay of cytoreductive surgery and heated intraperitoneal chemotherapy in patients with appendiceal neoplasm. ( 22748531 )	El Halabi H....Sardi A.	2012
30	Mucinous appendiceal neoplasms. Do we all speak the same language? ( 22300121 )	Darriba-Fern?ndez MU...Hern?ndez-Ga??n J	2012
31	Aggressive management of peritoneal carcinomatosis from mucinous appendiceal neoplasms. ( 22302270 )	Austin F...Choudry HA	2012
32	Inflammatory markers in blood and serum tumor markers predict survival in patients with epithelial appendiceal neoplasms undergoing surgical cytoreduction and intraperitoneal chemotherapy. ( 22750758 )	Chua TC...Morris DL	2012
33	Is malignant dedifferentiation for mucinous appendiceal neoplasms a valid phenomenon or merely histopathologic ambiguity? ( 21530846 )	Raghav KP...Overman MJ	2011
34	How should we treat mucinous appendiceal neoplasm? By laparoscopy or laparotomy? A case report. ( 20514834 )	Liberale G....El Nakadi I.	2010
35	Significant association of appendiceal neoplasms and ulcerative colitis rather than Crohn's disease. ( 19705419 )	Matsushita M...Okazaki K	2010
36	Clinicopathological analysis of primary epithelial appendiceal neoplasms. ( 19851895 )	Gupta S...El-Rayes BF	2010
37	Incidence of synchronous appendiceal neoplasm in patients with colorectal cancer and its clinical significance. ( 19490638 )	Lohsiriwat V....Lohsiriwat D.	2009
38	Epithelial appendiceal neoplasms. ( 19556909 )	Sugarbaker PH	2009
39	Diverticular disease of the vermiform appendix: a diagnostic clue to underlying appendiceal neoplasm. ( 18715614 )	Dupre M.P....Urbanski S.J.	2008
40	Mucinous appendiceal neoplasms: preoperative MR staging and classification compared with surgical and histopathologic findings. ( 18287436 )	Low RN...Muller WD	2008
41	The porta hepatis as a site of recurrence of mucinous appendiceal neoplasms treated by cytoreductive surgery and perioperative intraperitoneal chemotherapy. ( 19112943 )	Sugarbaker PH...Bijelic L	2008
42	Early results of surgery in 123 patients with pseudomyxoma peritonei from a perforated appendiceal neoplasm. ( 17115339 )	Murphy E.M....Moran B.J.	2007
43	Management of an unexpected appendiceal neoplasm. ( 16775823 )	Murphy E.M....Moran B.J.	2006
44	Appendiceal neoplasms with peritoneal dissemination: outcomes after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy. ( 16538401 )	Stewart JH...Levine EA	2006
45	The "alphabet soup" of peritoneal dissemination from appendiceal neoplasms and other malignancies. ( 16538404 )	Kane JM	2006
46	Primary appendiceal neoplasms. ( 8270409 )	Hananel N...Wolloch Y	1993
47	Adenocarcinoma of the colon associated with benign appendiceal neoplasm. ( 7089665 )	Toedebusch W.H....O'Connor W.N.	1982

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Genes for Appendiceal Neoplasm

Genes related to Appendiceal Neoplasm (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	YARS	Tyrosyl-TRNA Synthetase	Protein Coding	15.42	DISEASES inferred ¹⁵
2	RHCE	Rh Blood Group CcEe Antigens	Protein Coding	15	DISEASES inferred ¹⁵
3	KRT20	Keratin 20	Protein Coding	14.23	DISEASES inferred ¹⁵
4	POLB	DNA Polymerase Beta	Protein Coding	14.06	DISEASES inferred ¹⁵
5	KRT7	Keratin 7	Protein Coding	14	DISEASES inferred ¹⁵
6	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	13.88	DISEASES inferred ¹⁵
7	CTNNB1	Catenin Beta 1	Protein Coding	13.72	DISEASES inferred ¹⁵
8	CDH1	Cadherin 1	Protein Coding	13.3	DISEASES inferred ¹⁵
9	TP53	Tumor Protein P53	Protein Coding	13.11	DISEASES inferred ¹⁵
10	MUC6	Mucin 6, Oligomeric Mucus/Gel-Forming	Protein Coding	13.1	DISEASES inferred ¹⁵
11	TIMM13	Translocase Of Inner Mitochondrial Membrane 13	Protein Coding	6.02	DISEASES inferred ¹⁵
12	CLDN11	Claudin 11	Protein Coding	5.22	DISEASES inferred ¹⁵

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Variations for Appendiceal Neoplasm

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Expression for Appendiceal Neoplasm

Search GEO for disease gene expression data for Appendiceal Neoplasm.

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Pathways for Appendiceal Neoplasm

Pathways related to Appendiceal Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Colorectal Cancer Metastasis ⁶⁵	11.72	CDH1 CTNNB1 TP53
2	Integrated Breast Cancer Pathway ¹	11.62	CDH1 CTNNB1 TP53
3	Adhesion ⁴	11.42	CDH1 CTNNB1 MUC1
4	Cytoskeletal Signaling ⁴	11.41	CDH1 KRT20 KRT7 MUC1
5	Nectin adhesion pathway ¹	10.77	CDH1 CTNNB1
6	RHO GTPases activate IQGAPs ⁶⁷	10.07	CDH1 CTNNB1

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GO Terms for Appendiceal Neoplasm

Cellular components related to Appendiceal Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	catenin complex	GO:0016342	9.16	CDH1 CTNNB1
2	apical junction complex	GO:0043296	8.96	CDH1 CTNNB1
3	flotillin complex	GO:0016600	8.62	CDH1 CTNNB1

Biological processes related to Appendiceal Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	response to gamma radiation	GO:0010332	9.26	POLB TP53
2	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	9.16	MUC1 TP53
3	entry of bacterium into host cell	GO:0035635	8.96	CDH1 CTNNB1
4	cellular response to indole-3-methanol	GO:0071681	8.62	CDH1 CTNNB1

Sources

Sources for Appendiceal Neoplasm

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

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⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

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¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

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²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia