MCID: APP003
MIFTS: 29

Appendiceal Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Appendiceal Neoplasm

MalaCards integrated aliases for Appendiceal Neoplasm:

Name: Appendiceal Neoplasm 12 15 17
Appendiceal Neoplasms 54
Neoplasm of Appendix 12
Appendix Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11240
MeSH 43 D001063
NCIt 49 C4434
UMLS 71 C0003614

Summaries for Appendiceal Neoplasm

MalaCards based summary : Appendiceal Neoplasm, also known as appendiceal neoplasms, is related to appendix cancer and cystadenoma. An important gene associated with Appendiceal Neoplasm is CDX2 (Caudal Type Homeobox 2). The drugs leucovorin and Oxaliplatin have been mentioned in the context of this disorder. Affiliated tissues include appendix, colon and ovary.

Related Diseases for Appendiceal Neoplasm

Diseases related to Appendiceal Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 256)
# Related Disease Score Top Affiliating Genes
1 appendix cancer 31.6 SATB2 KRT7 KRAS CEACAM5 CDX2
2 cystadenoma 30.1 KRT7 CHGA CEACAM5
3 pseudomyxoma peritonei 30.1 KRT7 KRAS CEACAM5 CDX2
4 adenocarcinoma 29.8 KRT7 KRAS CEACAM5 CDX2
5 krukenberg carcinoma 29.6 SATB2 KRT7 CEACAM5 CDX2
6 mucinous adenocarcinoma 29.6 KRT7 KRAS CEACAM5 CDX2
7 villous adenoma 29.6 KRAS CEACAM5 CDX2
8 ovarian cystadenocarcinoma 29.4 SPINK5 KRAS CEACAM5
9 adenoma 29.3 KRT7 KRAS CHGA CDX2
10 appendix adenocarcinoma 29.1 SATB2 KRT7 KRAS CEACAM5 CDX2
11 signet ring cell adenocarcinoma 28.4 KRT7 KRAS CHGA CEACAM5 CDX2
12 colorectal adenocarcinoma 28.0 SATB2 KRT7 KRAS CHGA CEACAM5 CDX2
13 appendicitis 10.5
14 thymus adenocarcinoma 10.4 CEACAM5 CDX2
15 bladder signet ring cell adenocarcinoma 10.4 KRT7 CDX2
16 ovary neuroendocrine neoplasm 10.4 KRT7 CDX2
17 ovarian cystadenoma 10.4 KRT7 CEACAM5
18 anal canal paget's disease 10.4 KRT7 CDX2
19 gastric signet ring cell adenocarcinoma 10.4 KRT7 CDX2
20 adenosquamous colon carcinoma 10.4 KRT7 CDX2
21 anus adenocarcinoma 10.4 KRT7 CDX2
22 rectum neuroendocrine neoplasm 10.4 KRT7 CDX2
23 urethral villous adenoma 10.4 KRT7 CEACAM5
24 cystitis cystica 10.4 KRT7 CDX2
25 ovarian seromucinous carcinoma 10.4 KRT7 CDX2
26 malignant spiradenoma 10.4 KRT7 CEACAM5
27 cutaneous mucoepidermoid carcinoma 10.4 KRT7 CEACAM5
28 seminal vesicle adenocarcinoma 10.4 KRT7 CEACAM5
29 anal canal adenocarcinoma 10.4 KRT7 CDX2
30 aortic malignant tumor 10.4 KRT7 CEACAM5
31 eccrine porocarcinoma 10.4 KRT7 CEACAM5
32 vulval paget's disease 10.4 KRT7 CEACAM5
33 sigmoid neoplasm 10.4 KRT7 CEACAM5
34 eccrine adenocarcinoma 10.4 KRT7 CEACAM5
35 renal pelvis adenocarcinoma 10.4 KRT7 CEACAM5
36 external ear carcinoma 10.4 KRT7 CEACAM5
37 bile duct cystadenocarcinoma 10.3 KRT7 CEACAM5
38 colonic lymphangioma 10.3 KRT7 CEACAM5
39 vulvar apocrine adenocarcinoma 10.3 KRT7 CEACAM5
40 glandular cystitis 10.3 KRT7 CDX2
41 eccrine papillary adenocarcinoma 10.3 KRT7 CEACAM5
42 malignant syringoma 10.3 KRT7 CEACAM5
43 syringoma 10.3 KRT7 CEACAM5
44 mucinous stomach adenocarcinoma 10.3 KRT7 CDX2
45 bile duct mucoepidermoid carcinoma 10.3 KRT7 CEACAM5
46 clear cell hidradenoma 10.3 KRT7 CEACAM5
47 hidradenoma 10.3 KRT7 CEACAM5
48 eccrine sweat gland cancer 10.3 KRT7 CEACAM5
49 sweat gland cancer 10.3 KRT7 CEACAM5
50 hidrocystoma 10.3 KRT7 CEACAM5

Graphical network of the top 20 diseases related to Appendiceal Neoplasm:



Diseases related to Appendiceal Neoplasm

Symptoms & Phenotypes for Appendiceal Neoplasm

Drugs & Therapeutics for Appendiceal Neoplasm

Drugs for Appendiceal Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 2 58-05-9 6006 143
2
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 6857599 43805
3
Fluorouracil Approved Phase 2 51-21-8 3385
4
nivolumab Approved Phase 2 946414-94-4
5
Ipilimumab Approved Phase 2 477202-00-9
6
Nintedanib Approved Phase 2 656247-17-5 56843413
7
Durvalumab Approved, Investigational Phase 1, Phase 2 1428935-60-7
8
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
9
Floxuridine Approved Phase 2 50-91-9 5790
10
Clarithromycin Approved Phase 2 81103-11-9 84029
11
Amoxicillin Approved, Vet_approved Phase 2 26787-78-0 33613
12
Lansoprazole Approved, Investigational Phase 2 103577-45-3 3883
13
Dexlansoprazole Approved, Investigational Phase 2 138530-94-6, 103577-45-3 9578005
14
carbamide peroxide Approved Phase 2 124-43-6
15
Melphalan Approved Phase 2 148-82-3 4053 460612
16 Antineoplastic Agents, Immunological Phase 2
17 Antibodies, Monoclonal Phase 1, Phase 2
18 Immunoglobulins Phase 1, Phase 2
19 Immunologic Factors Phase 1, Phase 2
20 Antibodies Phase 1, Phase 2
21 Anti-Bacterial Agents Phase 2
22 Alkylating Agents Phase 2
23 Antibiotics, Antitubercular Phase 2
24 Mitomycins Phase 2
25 Cola Phase 2
26 Anti-Infective Agents Phase 2
27 Cytochrome P-450 CYP3A Inhibitors Phase 2
28 Antitubercular Agents Phase 2
29 Proton Pump Inhibitors Phase 2
30 Anti-Ulcer Agents Phase 2
31 Gastrointestinal Agents Phase 2
32 Cytochrome P-450 Enzyme Inhibitors Phase 2
33 Antacids Phase 2
34 Immunosuppressive Agents Phase 2
35
Irinotecan Approved, Investigational Phase 1 97682-44-5, 100286-90-6 60838
36 Tin Fluorides Phase 1
37
Doxorubicin Approved, Investigational 23214-92-8 31703
38
Paclitaxel Approved, Vet_approved 33069-62-4 36314
39
Gemcitabine Approved 95058-81-4 60750
40
Cisplatin Approved 15663-27-1 84093 441203 2767
41 Pharmaceutical Solutions
42 Antimitotic Agents
43
Liposomal doxorubicin 31703
44 Albumin-Bound Paclitaxel
45 Topoisomerase Inhibitors

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Repetitive Electrostatic Pressurised Intraperitoneal Aerosol Chemotherapy With Oxaliplatin (ePIPAC-OX) as a Palliative Monotherapy for Isolated Unresectable Colorectal Peritoneal Metastases: Protocol of a Multicentre, Open-label, Single-arm, Phase II Study (CRC-PIPAC) Completed NCT03246321 Phase 2
2 A Phase II Study of Nivolumab and Ipilimumab in Mucinous Colorectal and Appendiceal Tumors Recruiting NCT03693846 Phase 2 Nivolumab;Ipilimumab
3 LCI-GI-APX-NIN-001: Nintedanib in Metastatic Appendiceal Carcinoma Recruiting NCT03287947 Phase 2 nintedanib
4 A Phase 1/2 Dose Escalation Study With Expansion Cohorts to Investigate the Safety, Biologic and Anti-tumor Activity of ONCOS-102 in Combination With Durvalumab in Subjects With Advanced Peritoneal Malignancies Recruiting NCT02963831 Phase 1, Phase 2 Durvalumab
5 ICARuS (Intraperitoneal Chemotherapy After cytoReductive Surgery): A Multi-center, Randomized Phase II Trial of Early Post-operative Intraperitoneal Chemotherapy (EPIC) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) After Optimal Cytoreductive Surgery (CRS) for Neoplasms of the Appendix, Colon or Rectum With Isolated Peritoneal Metastasis Recruiting NCT01815359 Phase 2 HIPEC with Mitomycin-C;EPIC with FUDR and Leucovorin
6 Clinical Trial to Define the Effect of Perioperative H. Pylori Eradication With Antibiotic Treatment on the Long Term Outcomes of Patients With Pseudomyxoma Peritonei of Appendiceal Origin Undergoing Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy (CRS/HIPEC) Recruiting NCT02387203 Phase 2 PrevPac (Prevacid, Amoxicillin, Clarithromycin)
7 Phase II Single-Blind Randomized Trial Comparing Morbidity of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) Using Mitomycin-C Versus Melphalan for Colorectal Peritoneal Carcinomatosis Recruiting NCT03073694 Phase 2 Mitomycin c;Melphalan
8 Single Arm Study Treating Patients of Peritoneal Surface Malignancy (Colorectal, Appendical, Pseudomyxoma, Gastric) With Cytoreductive Surgery and Hyperthermic Intraperitoneal Mitomycin-C Recruiting NCT02040142 Phase 2 Mitomycin C
9 Phase I Trial of Intraperitoneal Oxaliplatin in Combination With Intravenous FOLFIRI (5-fluorouracil, Leucovorin and Irinotecan) for Peritoneal Carcinomatosis From Colorectal and Appendiceal Cancer Recruiting NCT02833753 Phase 1 Oxaliplatin
10 Phase I Trial of Intraperitoneal Oxaliplatin in Combination With Intravenous mFOLFIRI for Peritoneal Carcinomatosis From Colorectal and Appendiceal Cancer Not yet recruiting NCT04158349 Phase 1 Oxaliplatin;mFOLFIRI
11 A Survey of the Knowledge, Attitudes, and Practice of Surgeons Toward Nutrition Support in HIPEC Patients Completed NCT02374411
12 A Cohort Study of the Gastrointestinal Microbiome in Appendiceal Cancer With Peritoneal Spread Recruiting NCT02599116
13 Multicenter, International Online Documentation of Indications and Results of Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC Und PITAC) for Treating Malignant Peritoneal and Pleural Diseases Recruiting NCT03210298
14 5-hydroxymethylation Signatures in Plasma Circulating Cell-free DNA as Markers for Tumor Burden and Recurrence in Appendiceal and Colorectal Peritoneal Metastasis Recruiting NCT04157322
15 Selective Rather Than Routine Histopathological Examination After Appendectomy and Cholecystectomy; the FANCY Study Recruiting NCT03510923
16 Trial of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Patients With Primary Peritoneal Cancers and Secondary Peritoneal Cancers From Stomach, Colorectal, Appendiceal, and/or Gynecological Origins Recruiting NCT03604653 Mitomycin c;CDDP 50;CDDP 75;Doxorubicin
17 Distant Metastases and Long-Term Survival After Complete Resection of Neuroendocrine Tumors of the Appendix: An International Multicenter Study Not yet recruiting NCT03852693
18 The Master Registry of Oncology Outcomes Associated With Testing and Treatment (ROOT) Not yet recruiting NCT04028479 Treatment: CAR-T

Search NIH Clinical Center for Appendiceal Neoplasm

Genetic Tests for Appendiceal Neoplasm

Anatomical Context for Appendiceal Neoplasm

MalaCards organs/tissues related to Appendiceal Neoplasm:

40
Appendix, Colon, Ovary, Thyroid, Lung, Uterus, Thymus

Publications for Appendiceal Neoplasm

Articles related to Appendiceal Neoplasm:

(show top 50) (show all 94)
# Title Authors PMID Year
1
Predictors of Anastomotic Failure After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Does Technique Matter? 61
31659645 2020
2
Multi-origin mucinous neoplasm: Should we prophylactically remove the appendix in the setting of mucinous ovarian tumors? 61
31901742 2020
3
Laparoscopic hyperthermic intraperitoneal chemotherapy for appendiceal tumors. 61
31997552 2020
4
Synchronous primary neuroendocrine and mucinous epithelial tumors present in the same appendix. Case report of 2 patients. 61
32035310 2020
5
Risk factors for appendiceal neoplasm and malignancy among patients with acute appendicitis. 61
31811385 2020
6
Early recurrence in peritoneal metastasis of appendiceal neoplasm: Survival and prognostic factors. 61
31253546 2019
7
Safety and cost analysis of selective histopathological examination following appendicectomy and cholecystectomy (FANCY study): protocol and statistical analysis plan of a prospective observational multicentre study. 61
31874901 2019
8
Impact of Referral Center Pathology Review on Diagnosis and Management of Patients With Appendiceal Neoplasms. 61
31714810 2019
9
History of pseudomyxoma peritonei from its origin to the first decades of the twenty-first century. 61
31572561 2019
10
Appendiceal mucocele secondary to torsion in an asymptomatic patient. 61
31428310 2019
11
Low-grade Appendiceal Mucinous Neoplasm in the Context of Acute Appendicitis. 61
31528511 2019
12
The Understated Malignancy Potential of Nonoperative Acute Appendicitis. 61
31405413 2019
13
Risk of Appendiceal Neoplasm in Periappendicular Abscess in Patients Treated With Interval Appendectomy vs Follow-up With Magnetic Resonance Imaging: 1-Year Outcomes of the Peri-Appendicitis Acuta Randomized Clinical Trial. 61
30484824 2019
14
Appendiceal Malignancy: The Hidden Risks of Nonoperative Management for Acute Appendicitis. 61
30819303 2019
15
Appendiceal neoplasm risk associated with complicated acute appendicitis-a population based study. 61
30242478 2019
16
Tubulo-villous adenoma of the appendix: A case report and review of the literature. 61
31349156 2019
17
Mucinous appendiceal neoplasms: pathologic classification, clinical implications, imaging spectrum and mimics. 61
29564494 2018
18
Clinical significance of appendiceal diverticulum: a significant marker for appendiceal neoplasia in Australian patients. 61
29785461 2018
19
Appendiceal intussusception requiring an ileocecectomy: a case report and comment on the optimal surgery. 61
30068337 2018
20
Analysis of Appendiceal Neoplasms on 3544 Appendectomy Specimens for Acute Appendicitis: Retrospective Cohort Study of a Single Institution. 61
29947345 2018
21
Psoas/iliacus muscle invasion from mucinous appendiceal neoplasm. Radiologic appearance and outcome of treatment in 3 patients. 61
29937165 2018
22
Diagnostic and therapeutic laparoscopy in assessment and management of patients with appendiceal neoplasms. 61
28605985 2018
23
Single-center analysis of appendiceal neoplasms. 61
29731850 2018
24
[Diverticulosis and diverticulitis of the vermiform appendix. Report of a case and review of the literature]. 61
29730945 2018
25
Unusual case of intraluminal cecal recurrence of a low grade appendiceal mucinous neoplasm (LAMN)-Case report and brief literature review. 61
30149327 2018
26
Occult Appendiceal Neoplasms in Acute and Chronic Appendicitis: A Single-Institution Experience of 1793 Appendectomies. 61
29336758 2017
27
Utility of Appendiceal Calcifications Detected on Computed Tomography as a Predictor for an Underlying Appendiceal Epithelial Neoplasm. 61
28831698 2017
28
Pseudomyxoma peritonei due to low-grade appendiceal mucinous neoplasm with symptoms of inguinal hernia and uterine prolapse: a case report and review of the literature. 61
31149493 2017
29
Appendiceal neoplasm presenting as intussusception in an adult - a video vignette. 61
28235158 2017
30
Histological Subtype Remains a Significant Prognostic Factor for Survival Outcomes in Patients With Appendiceal Mucinous Neoplasm With Peritoneal Dissemination. 61
28267002 2017
31
Amyand's hernia containing an appendiceal goblet cell carcinoid tumour. 61
28302663 2017
32
Radical appendectomy as an alternative to right colon resection in patients with epithelial appendiceal neoplasms. 61
28317590 2017
33
Diarrhea Concealing a Duodenal-Cecal Fistula Secondary to Appendiceal Mucinous Neoplasm. 61
28138447 2017
34
Acute appendicitis, inflammatory appendiceal mass and the risk of a hidden malignant tumor: a systematic review of the literature. 61
28286544 2017
35
Goblet cell carcinoids of the appendix: Tumor biology, mutations and management strategies. 61
27830037 2016
36
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei and Appendix Tumours. 61
27065707 2016
37
Ileocecal Intussusception Caused by an Appendiceal Neoplasm. 61
26831058 2016
38
A giant mucinous cystadenocarcinoma of the appendix: a case report and review of the literature. 61
26945579 2016
39
Diagnosis and Treatment of Mucinous Appendiceal Neoplasm Presented as Acute Appendicitis. 61
27066284 2016
40
Corrigendum to "Diagnosis and Treatment of Mucinous Appendiceal Neoplasm Presented as Acute Appendicitis". 61
27957365 2016
41
Synchronous Renal Cell Carcinoma and Gastrointestinal Malignancies. 61
26904353 2016
42
Identification of Differentially Expressed miRNAs in Appendiceal Mucinous Cystadenocarcinoma from Mucinous Cystadenoma. 61
26807210 2015
43
Extreme cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: Outcomes from a single tertiary center. 61
26143715 2015
44
Is there truly an oncologic indication for interval appendectomy? 61
25543294 2015
45
Low Grade Appendiceal Mucinous Neoplasm with Pseudomyxoma Peritonei: An Enigma for Pathologist. 61
29699361 2014
46
Single-incision laparoscopic cecectomy for low-grade appendiceal mucinous neoplasm after laparoscopic rectectomy. 61
24868331 2014
47
[Peritoneal pseudomyxoma: an overview emphasizing pathological assessment and therapeutic strategies]. 61
24630633 2014
48
Adenocarcinomas of appendix: a rare tumor. Two case reports. 61
25524188 2014
49
Appendiceal mucosal Schwann cell proliferation: a putative histologic marker of appendiceal diverticular disease. 61
23842004 2013
50
Low-grade appendiceal neoplasm presenting as a volvulus of the cecum. 61
24759968 2013

Variations for Appendiceal Neoplasm

Expression for Appendiceal Neoplasm

Search GEO for disease gene expression data for Appendiceal Neoplasm.

Pathways for Appendiceal Neoplasm

GO Terms for Appendiceal Neoplasm

Sources for Appendiceal Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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