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MCID: APP003
MIFTS: 31

Appendiceal Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Appendiceal Neoplasm

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MalaCards integrated aliases for Appendiceal Neoplasm:

Name: Appendiceal Neoplasm 12 15 17
Appendiceal Neoplasms 55
Neoplasm of Appendix 12
Appendix Neoplasm 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:11240
MeSH 44 D001063
NCIt 50 C4434
UMLS 72 C0003614
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Summaries for Appendiceal Neoplasm

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MalaCards based summary : Appendiceal Neoplasm, also known as appendiceal neoplasms, is related to appendix cancer and pseudomyxoma peritonei. An important gene associated with Appendiceal Neoplasm is SATB2 (SATB Homeobox 2). The drugs nivolumab and Ipilimumab have been mentioned in the context of this disorder. Affiliated tissues include appendix, colon and liver, and related phenotypes are cellular and digestive/alimentary

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Related Diseases for Appendiceal Neoplasm

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Diseases related to Appendiceal Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 appendix cancer 32.0 KRT7 GNAS CDX2
2 pseudomyxoma peritonei 30.9 KRT7 CDX2
3 appendix adenocarcinoma 30.4 KRT7 CDX2
4 mucinous adenocarcinoma 30.4 KRT7 CDX2
5 signet ring cell adenocarcinoma 30.0 KRT7 CDX2
6 villous adenoma 29.7 GNAS CDX2
7 colorectal adenocarcinoma 29.6 KRT7 CDX2
8 appendicitis 10.5
9 adenocarcinoma 10.3
10 familial colorectal cancer type x 10.3
11 neuroendocrine neoplasm of appendix 10.3
12 glass syndrome 10.3 SATB2 HMOX2
13 ovary neuroendocrine neoplasm 10.3 KRT7 CDX2
14 anus adenocarcinoma 10.2 KRT7 CDX2
15 mucinous adenofibroma 10.2 KRT7 CDX2
16 glandular cystitis 10.2 KRT7 CDX2
17 epithelial predominant wilms' tumor 10.2 KRT7 CDX2
18 duodenum adenocarcinoma 10.2 KRT7 CDX2
19 gastric diffuse adenocarcinoma 10.2 KRT7 CDX2
20 thymus adenocarcinoma 10.2 KRT7 CDX2
21 ovarian mucinous adenocarcinoma 10.2 KRT7 CDX2
22 nasal cavity cancer 10.2 KRT7 CDX2
23 jejunal adenocarcinoma 10.2 KRT7 CDX2
24 nasal cavity adenocarcinoma 10.2 KRT7 CDX2
25 bladder adenocarcinoma 10.2 KRT7 CDX2
26 vulva adenocarcinoma 10.2 KRT7 CDX2
27 chronic cystitis 10.2 KRT7 CDX2
28 anal canal adenocarcinoma 10.2 KRT7 CDX2
29 rectum adenocarcinoma 10.2 KRT7 CDX2
30 mucinous bronchioloalveolar adenocarcinoma 10.2 KRT7 CDX2
31 adenoma 10.2
32 biliary papillomatosis 10.2 KRT7 CDX2
33 ampulla of vater adenocarcinoma 10.2 KRT7 CDX2
34 endocervical adenocarcinoma 10.2 KRT7 CDX2
35 cervical adenocarcinoma 10.2 KRT7 CDX2
36 cystic teratoma 10.2 KRT7 CDX2
37 teratoma 10.2 KRT7 CDX2
38 horseshoe kidney 10.2 KRT7 CDX2
39 hidradenocarcinoma 10.1 KRT7 CDX2
40 adenocarcinoma in situ 10.1 KRT7 CDX2
41 microcephaly 5, primary, autosomal recessive 10.1 SATB2 HMOX2
42 anus cancer 10.1 KRT7 CDX2
43 intussusception 10.1
44 cystadenoma 10.1
45 duodenum cancer 10.1 KRT7 CDX2
46 gastric tubular adenocarcinoma 10.1 KRT7 CDX2
47 cecum adenocarcinoma 10.1 KRT7 CDX2
48 cystitis cystica 10.1 KRT7 CDX2
49 ampulla of vater cancer 10.1 KRT7 CDX2
50 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0

Graphical network of the top 20 diseases related to Appendiceal Neoplasm:



Diseases related to Appendiceal Neoplasm
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Symptoms & Phenotypes for Appendiceal Neoplasm

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MGI Mouse Phenotypes related to Appendiceal Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.35 CDX2 GNAS KRT7 RNF43 SATB2
2 digestive/alimentary MP:0005381 8.92 CDX2 HMOX2 RNF43 SATB2
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Drugs & Therapeutics for Appendiceal Neoplasm

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Drugs for Appendiceal Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2
Ipilimumab Approved Phase 2 477202-00-9
3
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
4
Durvalumab Approved, Investigational Phase 1, Phase 2 1428935-60-7
5
Floxuridine Approved Phase 2 50-91-9 5790
6
leucovorin Approved Phase 2 58-05-9 143 6006
7
Nintedanib Approved Phase 2 656247-17-5 56843413
8
Dexlansoprazole Approved, Investigational Phase 2 103577-45-3, 138530-94-6 9578005
9
Clarithromycin Approved Phase 2 81103-11-9 84029
10
Amoxicillin Approved, Vet_approved Phase 2 26787-78-0 33613
11
carbamide peroxide Approved Phase 2 124-43-6
12
Lansoprazole Approved, Investigational Phase 2 103577-45-3 3883
13
Melphalan Approved Phase 2 148-82-3 460612 4053
14
Fluorouracil Approved Phase 2 51-21-8 3385
15
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 43805 6857599
16
Irinotecan Approved, Investigational Phase 2 100286-90-6, 97682-44-5 60838
17
Palonosetron Approved, Investigational Phase 2 119904-90-4, 135729-61-2, 135729-56-5 148211
18 Angiogenesis Inhibitors Phase 2
19 Angiogenesis Modulating Agents Phase 2
20 Antineoplastic Agents, Immunological Phase 2
21 Antibodies Phase 1, Phase 2
22 Immunologic Factors Phase 1, Phase 2
23 Antibodies, Monoclonal Phase 1, Phase 2
24 Immunoglobulins Phase 1, Phase 2
25 Cytochrome P-450 CYP3A Inhibitors Phase 2
26 Anti-Infective Agents Phase 2
27 Cytochrome P-450 Enzyme Inhibitors Phase 2
28 Antitubercular Agents Phase 2
29 Antacids Phase 2
30 Proton Pump Inhibitors Phase 2
31 Anti-Ulcer Agents Phase 2
32 Immunosuppressive Agents Phase 2
33 Antineoplastic Agents, Alkylating Phase 2
34 Antimetabolites Phase 2
35 Antimetabolites, Antineoplastic Phase 2
36 Alkylating Agents Phase 2
37 Nucleic Acid Synthesis Inhibitors Phase 2
38 Antibiotics, Antitubercular Phase 2
39 Mitomycins Phase 2
40 Anti-Bacterial Agents Phase 2
41 topoisomerase I inhibitors Phase 2
42 Topoisomerase Inhibitors Phase 2
43 Cola Phase 2
44 Gastrointestinal Agents Phase 2
45 Neurotransmitter Agents Phase 2
46 Antiemetics Phase 2
47 Peripheral Nervous System Agents Phase 2
48 Serotonin Antagonists Phase 2
49 Serotonin 5-HT3 Receptor Antagonists Phase 2
50 Serotonin Agents Phase 2

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 Randomized Therapeutic Study Comparing Tumor Resection Followed Immediately by Intraperitoneal Chemotherapy and Systemic Chemotherapy VS Systemic Chemotherapy Alone for the Treatment of Colorectal Cancer Metastatic to the Peritoneum Unknown status NCT00006112 Phase 2 chemotherapy;fluorouracil;leucovorin calcium;mitomycin C
2 Phase II Trial of Adjuvant Thalidomide Following Cytoreductive Surgery and Intraperitoneal Hyperthermic Chemotherapy for Peritoneal Carcinomatosis or Adenomucinosis From Colorectal/Appendiceal Cancer Completed NCT00310076 Phase 2 thalidomide
3 A Multi-Center, Open-Label, Randomized Phase II Trial to Evaluate Hematologic Toxicities After HIPEC With Oxaliplatin or Mitomycin C in Patients With Appendiceal Tumors Completed NCT01580410 Phase 2 mitomycin C;oxaliplatin;hyperthermic intraperitoneal chemotherapy
4 A Phase II Study of Nivolumab and Ipilimumab in Mucinous Colorectal and Appendiceal Tumors Recruiting NCT03693846 Phase 2 Nivolumab;Ipilimumab
5 A Phase 1/2 Dose Escalation Study With Expansion Cohorts to Investigate the Safety, Biologic and Anti-tumor Activity of ONCOS-102 in Combination With Durvalumab in Subjects With Advanced Peritoneal Malignancies Recruiting NCT02963831 Phase 1, Phase 2 Durvalumab
6 ICARuS (Intraperitoneal Chemotherapy After cytoReductive Surgery): A Multi-center, Randomized Phase II Trial of Early Post-operative Intraperitoneal Chemotherapy (EPIC) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) After Optimal Cytoreductive Surgery (CRS) for Neoplasms of the Appendix, Colon or Rectum With Isolated Peritoneal Metastasis Recruiting NCT01815359 Phase 2 HIPEC with Mitomycin-C;EPIC with FUDR and Leucovorin
7 LCI-GI-APX-NIN-001: Nintedanib in Metastatic Appendiceal Carcinoma Recruiting NCT03287947 Phase 2 nintedanib
8 Clinical Trial to Define the Effect of Perioperative H. Pylori Eradication With Antibiotic Treatment on the Long Term Outcomes of Patients With Pseudomyxoma Peritonei of Appendiceal Origin Undergoing Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy (CRS/HIPEC) Recruiting NCT02387203 Phase 2 PrevPac (Prevacid, Amoxicillin, Clarithromycin)
9 Phase II Single-Blind Randomized Trial Comparing Morbidity of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) Using Mitomycin-C Versus Melphalan for Colorectal Peritoneal Carcinomatosis Recruiting NCT03073694 Phase 2 Mitomycin c;Melphalan
10 Repetitive Electrostatic Pressurised Intraperitoneal Aerosol Chemotherapy With Oxaliplatin (ePIPAC-OX) as a Palliative Monotherapy for Isolated Unresectable Colorectal Peritoneal Metastases: Protocol of a Multicentre, Open-label, Single-arm, Phase II Study (CRC-PIPAC) Recruiting NCT03246321 Phase 2
11 Single Arm Study Treating Patients of Peritoneal Surface Malignancy (Colorectal, Appendical, Pseudomyxoma, Gastric) With Cytoreductive Surgery and Hyperthermic Intraperitoneal Mitomycin-C Enrolling by invitation NCT02040142 Phase 2 Mitomycin C
12 Treatment of a Cancerous Disease of the Peritoneum With Complete Cytoreductive Surgery With Intraperitoneal Chemohyperthermia Using Oxaliplatin Plus Irinotecan Terminated NCT00180960 Phase 2 Oxaliplatin and irinotecan
13 A Pilot Phase II, Randomized, Double Blind Trial of Palonosetron Versus Placebo to Prevent Radiation Therapy Induced Nausea and Vomiting Terminated NCT00903396 Phase 2 palonosetron hydrochloride
14 A Phase I Evaluation of Intraperitoneal Hyperthermic Chemoperfusion With Oxaliplatin for Peritoneal Surface Disemmination of Appendiceal and Colorectal Cancer Completed NCT00458809 Phase 1 oxaliplatin
15 Pilot Study of Oxaliplatin in Combination With Capecitabine in Adult Cancer Patients Completed NCT00019773 Phase 1 capecitabine;oxaliplatin
16 A Pharmacogenetic-Based Phase I Trial of Irinotecan, 5-Fluorouracil, and Leucovorin (FOLFIRI) in Patients With Advanced Gastrointestinal Cancer Completed NCT00654160 Phase 1 fluorouracil;irinotecan hydrochloride;leucovorin calcium
17 A Phase I Study of UCN-01 in Combination With Irinotecan in Resistant Solid Tumor Malignancies (Part I) and in Triple Negative (ER-Negative, PgR-Negative, HER-2 Not-Amplified) Recurrent Breast Cancers (Part II) Completed NCT00031681 Phase 1 7-hydroxystaurosporine;irinotecan hydrochloride
18 A Phase I Trial of Herceptin and Interleukin-12 Completed NCT00004074 Phase 1
19 A Phase I Clinical and Biological Evaluation of Combined EGFR Blockade With Erlotinib and Cetuximab in Patients With Advanced Cancer Completed NCT00397384 Phase 1 cetuximab;erlotinib hydrochloride
20 Phase I Trial of Intraperitoneal Oxaliplatin in Combination With Intravenous FOLFIRI (5-fluorouracil, Leucovorin and Irinotecan) for Peritoneal Carcinomatosis From Colorectal and Appendiceal Cancer Recruiting NCT02833753 Phase 1 Oxaliplatin
21 Multicenter, International Online Documentation of Indications and Results of Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC Und PITAC) for Treating Malignant Peritoneal and Pleural Diseases Unknown status NCT03210298
22 A Survey of the Knowledge, Attitudes, and Practice of Surgeons Toward Nutrition Support in HIPEC Patients Completed NCT02374411
23 HOPE Program: Quality of Life Enhancement and Survivorship Care Completed NCT01126346
24 A Cohort Study of the Gastrointestinal Microbiome in Appendiceal Cancer With Peritoneal Spread Recruiting NCT02599116
25 Selective Rather Than Routine Histopathological Examination After Appendectomy and Cholecystectomy; the FANCY Study Recruiting NCT03510923
26 Trial of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Patients With Primary Peritoneal Cancers and Secondary Peritoneal Cancers From Stomach, Colorectal, Appendiceal, and/or Gynecological Origins Recruiting NCT03604653 Mitomycin c;CDDP;CDDP;Doxorubicin
27 Distant Metastases and Long-Term Survival After Complete Resection of Neuroendocrine Tumors of the Appendix: An International Multicenter Study Not yet recruiting NCT03852693
28 The Master Registry of Oncology Outcomes Associated With Testing and Treatment (ROOT) Not yet recruiting NCT04028479 Treatment: CAR-T
29 Distribution Of The Photosensitizer Motexafin Lutetium And Hypoxia In Patients With Malignancies Terminated NCT00087191 EF5;motexafin lutetium

Search NIH Clinical Center for Appendiceal Neoplasm

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Genetic Tests for Appendiceal Neoplasm

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Anatomical Context for Appendiceal Neoplasm

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MalaCards organs/tissues related to Appendiceal Neoplasm:

41
Appendix, Colon, Liver, Testes, Breast, Ovary, Uterus
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Publications for Appendiceal Neoplasm

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Articles related to Appendiceal Neoplasm:

(show top 50) (show all 85)
# Title Authors PMID Year
1
Appendiceal mucocele secondary to torsion in an asymptomatic patient. 38
31428310 2019
2
Tubulo-villous adenoma of the appendix: A case report and review of the literature. 38
31349156 2019
3
The Understated Malignancy Potential of Nonoperative Acute Appendicitis. 38
31405413 2019
4
Early recurrence in peritoneal metastasis of appendiceal neoplasm: Survival and prognostic factors. 38
31253546 2019
5
Risk of Appendiceal Neoplasm in Periappendicular Abscess in Patients Treated With Interval Appendectomy vs Follow-up With Magnetic Resonance Imaging: 1-Year Outcomes of the Peri-Appendicitis Acuta Randomized Clinical Trial. 38
30484824 2019
6
Appendiceal Malignancy: The Hidden Risks of Nonoperative Management for Acute Appendicitis. 38
30819303 2019
7
Appendiceal neoplasm risk associated with complicated acute appendicitis-a population based study. 38
30242478 2019
8
Mucinous appendiceal neoplasms: pathologic classification, clinical implications, imaging spectrum and mimics. 38
29564494 2018
9
Clinical significance of appendiceal diverticulum: a significant marker for appendiceal neoplasia in Australian patients. 38
29785461 2018
10
Appendiceal intussusception requiring an ileocecectomy: a case report and comment on the optimal surgery. 38
30068337 2018
11
Analysis of Appendiceal Neoplasms on 3544 Appendectomy Specimens for Acute Appendicitis: Retrospective Cohort Study of a Single Institution. 38
29947345 2018
12
Psoas/iliacus muscle invasion from mucinous appendiceal neoplasm. Radiologic appearance and outcome of treatment in 3 patients. 38
29937165 2018
13
Diagnostic and therapeutic laparoscopy in assessment and management of patients with appendiceal neoplasms. 38
28605985 2018
14
Single-center analysis of appendiceal neoplasms. 38
29731850 2018
15
[Diverticulosis and diverticulitis of the vermiform appendix. Report of a case and review of the literature]. 38
29730945 2018
16
Unusual case of intraluminal cecal recurrence of a low grade appendiceal mucinous neoplasm (LAMN)-Case report and brief literature review. 38
30149327 2018
17
Occult Appendiceal Neoplasms in Acute and Chronic Appendicitis: A Single-Institution Experience of 1793 Appendectomies. 38
29336758 2017
18
Utility of Appendiceal Calcifications Detected on Computed Tomography as a Predictor for an Underlying Appendiceal Epithelial Neoplasm. 38
28831698 2017
19
Pseudomyxoma peritonei due to low-grade appendiceal mucinous neoplasm with symptoms of inguinal hernia and uterine prolapse: a case report and review of the literature. 38
31149493 2017
20
Appendiceal neoplasm presenting as intussusception in an adult - a video vignette. 38
28235158 2017
21
Histological Subtype Remains a Significant Prognostic Factor for Survival Outcomes in Patients With Appendiceal Mucinous Neoplasm With Peritoneal Dissemination. 38
28267002 2017
22
Amyand's hernia containing an appendiceal goblet cell carcinoid tumour. 38
28302663 2017
23
Radical appendectomy as an alternative to right colon resection in patients with epithelial appendiceal neoplasms. 38
28317590 2017
24
Acute appendicitis, inflammatory appendiceal mass and the risk of a hidden malignant tumor: a systematic review of the literature. 38
28286544 2017
25
Diarrhea Concealing a Duodenal-Cecal Fistula Secondary to Appendiceal Mucinous Neoplasm. 38
28138447 2017
26
Goblet cell carcinoids of the appendix: Tumor biology, mutations and management strategies. 38
27830037 2016
27
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei and Appendix Tumours. 38
27065707 2016
28
Ileocecal Intussusception Caused by an Appendiceal Neoplasm. 38
26831058 2016
29
A giant mucinous cystadenocarcinoma of the appendix: a case report and review of the literature. 38
26945579 2016
30
Corrigendum to "Diagnosis and Treatment of Mucinous Appendiceal Neoplasm Presented as Acute Appendicitis". 38
27957365 2016
31
Diagnosis and Treatment of Mucinous Appendiceal Neoplasm Presented as Acute Appendicitis. 38
27066284 2016
32
Synchronous Renal Cell Carcinoma and Gastrointestinal Malignancies. 38
26904353 2016
33
Identification of Differentially Expressed miRNAs in Appendiceal Mucinous Cystadenocarcinoma from Mucinous Cystadenoma. 38
26807210 2015
34
Extreme cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: Outcomes from a single tertiary center. 38
26143715 2015
35
Is there truly an oncologic indication for interval appendectomy? 38
25543294 2015
36
Low Grade Appendiceal Mucinous Neoplasm with Pseudomyxoma Peritonei: An Enigma for Pathologist. 38
29699361 2014
37
Single-incision laparoscopic cecectomy for low-grade appendiceal mucinous neoplasm after laparoscopic rectectomy. 38
24868331 2014
38
[Peritoneal pseudomyxoma: an overview emphasizing pathological assessment and therapeutic strategies]. 38
24630633 2014
39
Adenocarcinomas of appendix: a rare tumor. Two case reports. 38
25524188 2014
40
Appendiceal mucosal Schwann cell proliferation: a putative histologic marker of appendiceal diverticular disease. 38
23842004 2013
41
Low-grade appendiceal neoplasm presenting as a volvulus of the cecum. 38
24759968 2013
42
Antibiotic treatment decreases microbial burden associated with pseudomyxoma peritonei and affects β-catenin distribution. 38
23743566 2013
43
Surveillance MR imaging is superior to serum tumor markers for detecting early tumor recurrence in patients with appendiceal cancer treated with surgical cytoreduction and HIPEC. 38
23456382 2013
44
[Rectal goblet cell carcinoid. Primary tumor or metastasis?]. 38
22555364 2013
45
Pulmonary metastasis from a low grade mucinous appendiceal neoplasm. 38
23250037 2013
46
Goblet cell carcinoid neoplasm of the appendix: clinical and CT features. 38
23088880 2013
47
Management of the acute appendix mass: a survey of surgical practice. 38
23240283 2012
48
Inflammatory markers in blood and serum tumor markers predict survival in patients with epithelial appendiceal neoplasms undergoing surgical cytoreduction and intraperitoneal chemotherapy. 38
22750758 2012
49
Significance of acquired diverticular disease of the vermiform appendix: a marker of regional neoplasms? 38
22461655 2012
50
Delay of cytoreductive surgery and heated intraperitoneal chemotherapy in patients with appendiceal neoplasm. 38
22748531 2012
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Variations for Appendiceal Neoplasm

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Expression for Appendiceal Neoplasm

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Search GEO for disease gene expression data for Appendiceal Neoplasm.
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Pathways for Appendiceal Neoplasm

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GO Terms for Appendiceal Neoplasm

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Biological processes related to Appendiceal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cartilage development GO:0051216 8.62 SATB2 GNAS
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Sources for Appendiceal Neoplasm

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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