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MCID: APP008
MIFTS: 66

Appendicitis

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Appendicitis

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MalaCards integrated aliases for Appendicitis:

Name: Appendicitis 12 77 56 44 45 15 17 74
Acute Appendicitis 12 56 15
Acute Appendicitis with Generalized Peritonitis 12
Acute Appendicitis with Peritoneal Abscess 12
Acute Appendicitis Nos 74

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:8337
ICD9CM 36 540-543.99 541
MeSH 45 D001064
NCIt 51 C35145
SNOMED-CT 69 74400008
Sources

Summaries for Appendicitis

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MedlinePlus : 44 The appendix is a small, tube-like organ attached to the first part of the large intestine. It is located in the lower right part of the abdomen. It has no known function. A blockage inside of the appendix causes appendicitis. The blockage leads to increased pressure, problems with blood flow, and inflammation. If the blockage is not treated, the appendix can burst and spread infection into the abdomen. This causes a condition called peritonitis. The main symptom is pain in the abdomen, often on the right side. It is usually sudden and gets worse over time. Other symptoms may include Swelling in the abdomen Loss of appetite Nausea and vomiting Constipation or diarrhea Inability to pass gas Low fever Not everyone with appendicitis has all these symptoms. Appendicitis is a medical emergency. Treatment almost always involves removing the appendix. Anyone can get appendicitis, but it is more common among people 10 to 30 years old. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Appendicitis, also known as acute appendicitis, is related to diverticulitis and endometriosis, and has symptoms including fever, vomiting and pain. An important gene associated with Appendicitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Ertapenem and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include appendix, colon and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has symptom pain, in the upper abdomen initially and later in the lower abdomen, has symptom nausea, has symptom vomiting and has symptom fever.

Wikipedia : 77 Appendicitis is inflammation of the appendix. Symptoms commonly include right lower abdominal pain,... more...

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Related Diseases for Appendicitis

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Diseases related to Appendicitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 700)
# Related Disease Score Top Affiliating Genes
1 diverticulitis 31.2 CRP MMP9 TNF
2 endometriosis 30.9 CXCL8 IL1B IL6
3 inguinal hernia 30.8 IL6 MMP9 TIMP1
4 purpura 30.7 CRP IL6 TNF
5 fasciitis 30.7 CXCL8 IL6 TNF
6 crohn's disease 30.7 CRP IL10 TNF
7 salpingitis 30.7 CRP TNF
8 mesenteric lymphadenitis 30.6 CRP IL6 LBP
9 schistosomiasis 30.6 ALB IL10 TNF
10 peritonitis 30.6 ALB CRP CXCL8 IL10 IL1B IL6
11 familial mediterranean fever 30.3 CRP IL1B TNF
12 ileitis 30.2 IL6 MPO TNF
13 lymphadenitis 30.2 CXCL8 IL10 IL1B TNF
14 polyarteritis nodosa 30.1 CRP IL6 MPO
15 duodenal ulcer 30.1 CXCL8 IL1B TNF
16 leukomalacia 30.1 IL6 TNF
17 rheumatic fever 30.1 IL10 IL6 TNF
18 human immunodeficiency virus infectious disease 30.1 IL10 IL6 TNF
19 pharyngitis 30.0 CRP CXCL8 IL1B
20 aortic aneurysm, familial abdominal, 1 29.9 MMP8 MMP9 TIMP1
21 pyelitis 29.9 CRP CXCL8 IL6
22 aortitis 29.9 CRP MPO
23 perinatal necrotizing enterocolitis 29.9 CRP CXCL8 IL1B IL6 TNF
24 hematopoietic stem cell transplantation 29.9 IL10 IL6 TNF
25 rheumatic heart disease 29.9 IL10 IL6 TNF
26 bronchus cancer 29.9 CRP ENO2
27 microscopic polyangiitis 29.8 MPO TNF
28 colitis 29.8 CXCL8 IL10 IL1B IL6 MPO TNF
29 vasculitis 29.8 CRP MPO TNF
30 acquired immunodeficiency syndrome 29.8 ALB IL10 IL1B IL6 TNF
31 typhoid fever 29.8 ALB CRP IL1B IL6 TNF
32 placenta disease 29.7 CXCL8 IL1B IL6
33 osteomyelitis 29.7 CXCL8 IL10 IL1B IL6 TNF
34 peptic ulcer disease 29.7 CXCL8 IL10 IL1B TNF
35 gastric adenocarcinoma 29.7 CXCL8 IL1B MMP9 TNF
36 tuberculous peritonitis 29.7 ALB CRP TNF
37 pericarditis 29.7 CRP IL1B IL6 TNF
38 leishmaniasis 29.6 IL10 IL1B TNF
39 crohn's colitis 29.6 CXCL8 IL1B TNF
40 adult-onset still's disease 29.5 CRP IL1B IL6 TNF
41 reactive arthritis 29.5 CRP IL10 MMP8 TNF
42 dysentery 29.5 ALB CRP ENO2
43 acute pancreatitis 29.5 CRP CXCL8 IL10 IL6 MPO
44 tonsillitis 29.4 CXCL8 IL1B IL6 TNF
45 acute cystitis 29.4 ALB CRP CXCL8 IL6
46 cytomegalovirus infection 29.4 CXCL8 IL1B IL6 TNF
47 brain injury 29.4 ENO2 IL10 IL6
48 traumatic brain injury 29.4 ENO2 IL10 IL6
49 arthritis 29.4 CXCL8 IL10 IL1B IL6 MMP9 TNF
50 end stage renal failure 29.4 ALB CRP IL6 TNF

Graphical network of the top 20 diseases related to Appendicitis:



Diseases related to Appendicitis
Sources

Symptoms & Phenotypes for Appendicitis

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Symptoms:

12
  • • fever
  • • vomiting
  • • pain
  • • nausea

UMLS symptoms related to Appendicitis:


nausea and vomiting, constipation, abdominal pain, diarrhea, icterus, dyspepsia, heartburn, gastrointestinal gas

GenomeRNAi Phenotypes related to Appendicitis according to GeneCards Suite gene sharing:

27 (show all 28)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.85 MMP8 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.85 MPO
3 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.85 LBP
4 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.85 LBP
5 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.85 LBP
6 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.85 MPO
7 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.85 HMGB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.85 LBP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.85 HMGB1 LBP MMP8 MPO
10 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.85 MPO
11 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.85 MMP8
12 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.85 MMP8
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.85 MPO
14 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.85 MPO
15 Increased shRNA abundance (Z-score > 2) GR00366-A-41 9.85 MMP8
16 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.85 LBP MMP8
17 Increased shRNA abundance (Z-score > 2) GR00366-A-51 9.85 LBP
18 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.85 MMP8
19 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.85 MPO
20 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.85 HMGB1 LBP
21 Increased shRNA abundance (Z-score > 2) GR00366-A-69 9.85 HMGB1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.85 MPO
23 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.85 MPO
24 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.85 LBP
25 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.85 MMP8
26 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.85 HMGB1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.85 LBP
28 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.85 MMP8

MGI Mouse Phenotypes related to Appendicitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 ALB CRP IL10 IL1B IL6 LBP
2 cardiovascular system MP:0005385 10.06 CRP IL10 IL1B IL6 MMP9 MPO
3 hematopoietic system MP:0005397 10.02 IL10 IL1B IL6 LBP MMP9 MPO
4 immune system MP:0005387 10 CRP IL10 IL1B IL6 LBP MMP8
5 muscle MP:0005369 9.7 ALB IL10 IL6 MMP9 MPO PITX2
6 neoplasm MP:0002006 9.56 ALB IL10 IL1B IL6 MMP8 MMP9
7 respiratory system MP:0005388 9.17 ENO2 IL10 IL6 MMP9 PITX2 TIMP1
Sources

Drugs & Therapeutics for Appendicitis

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Drugs for Appendicitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 202)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ertapenem Approved, Investigational Phase 4,Phase 2,Early Phase 1,Not Applicable 153832-46-3 150610
2
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
3
Bupivacaine Approved, Investigational Phase 4,Phase 2,Not Applicable 38396-39-3, 2180-92-9 2474
4
Metronidazole Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 443-48-1 4173
5
Morphine Approved, Investigational Phase 4,Phase 1,Phase 2 57-27-2 5288826
6
Ropivacaine Approved Phase 4,Phase 1,Phase 2,Not Applicable 84057-95-4 175805 71273
7
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3 437-38-7 3345
8
Ofloxacin Approved Phase 4,Phase 2,Not Applicable 82419-36-1 4583
9
Levofloxacin Approved, Investigational Phase 4,Phase 2,Not Applicable 100986-85-4 149096
10
Ampicillin Approved, Vet_approved Phase 4,Not Applicable 69-53-4 6249
11
Ceftriaxone Approved Phase 4,Not Applicable 73384-59-5 5479530 5361919
12
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 26787-78-0 33613
13
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
14
Tigecycline Approved Phase 4,Not Applicable 220620-09-7 5282044
15
Glucagon Approved Phase 4,Phase 3 16941-32-5
16
Tazobactam Approved Phase 4,Phase 2,Not Applicable 89786-04-9 123630
17
Piperacillin Approved Phase 4,Phase 2,Not Applicable 66258-76-2 43672
18
Aztreonam Approved Phase 4 78110-38-0 5742832 5362041
19
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
20
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
21
Nalbuphine Approved Phase 4 20594-83-6 5311304 5360630
22 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
23 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
24 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
25 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
26 Hypnotics and Sedatives Phase 4,Phase 3,Not Applicable
27 Adrenergic alpha-Agonists Phase 4,Not Applicable
28 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
29 Adrenergic Agents Phase 4,Not Applicable
30 Adrenergic Agonists Phase 4,Not Applicable
31 Analgesics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
32 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
33 Neurotransmitter Agents Phase 4,Not Applicable
34 Adrenergic alpha-2 Receptor Agonists Phase 4
35 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
36 Anesthetics, Local Phase 4,Phase 1,Phase 2,Not Applicable
37 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
38 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
39 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
40 Analgesics, Opioid Phase 4,Phase 3
41 Narcotics Phase 4,Phase 3,Phase 1,Phase 2
42 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Not Applicable
43 Anti-Infective Agents, Urinary Phase 4,Phase 2,Not Applicable
44 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
45 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 2,Not Applicable
46 Renal Agents Phase 4,Phase 2,Not Applicable
47 Topoisomerase Inhibitors Phase 4,Phase 2,Not Applicable
48 Anesthetics, General Phase 4,Phase 3,Not Applicable
49 Gentamicins Phase 4,Not Applicable
50 beta-Lactamase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 234)
# Name Status NCT ID Phase Drugs
1 Antibiotics Versus Surgery in Acute Appendicitis Unknown status NCT01421901 Phase 4 Ertapenem
2 Intraperitoneal Dexmedetomidine for Post-laparoscopic Appendicectomy Pain Management in Children Unknown status NCT03067740 Phase 4 Bupivacaine;Dexmedetomidine
3 Safety and Efficacy of Single Daily Dose of Ceftriaxone and Metronidazole for Treatment of Complicated Appendicitis in Children Completed NCT01678365 Phase 4 ceftriaxone, metronidazole/ampicillin, gentamicin, and metronidazole
4 Effect of Pain Control on the Diagnosis of Acute Appendicitis on the Diagnostic Accuracy of General Surgeon Completed NCT00783016 Phase 4 Morphine
5 Morphine Analgesia in Patients With Acute Appendicitis Completed NCT00477061 Phase 4 Morphine
6 Non Operative Treatment for Acute Appendicitis Completed NCT01096927 Phase 4 Amoxicillin and Clavulanic Acid
7 A Comparison of UGBRS Block and Local Infiltration Completed NCT02352519 Phase 4
8 Laparoscopic Versus Open Appendectomy Completed NCT02867072 Phase 4
9 Appendicectomy Skin Closure Technique: Changing Paradigms (ASC) Completed NCT02625987 Phase 4
10 Choose the Best Concentration of Ropivacaine on TAP Block for Open Appendectomy in Children Completed NCT03005808 Phase 4 Ropivacaine
11 Wound Healing After Emergency Appendicectomy Completed NCT00913445 Phase 4
12 Pain Post Abdominal Laparoscopy Prevention With Arcoxia Completed NCT00565682 Phase 4 etoricoxib 120 mg
13 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection Completed NCT00195351 Phase 4 tigecycline;ceftriaxone sodium + metronidazole
14 Study of Tomography of Nephrolithiasis Evaluation Completed NCT01451931 Phase 4
15 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection (cIAI) Completed NCT00230971 Phase 4 tigecycline;ceftriaxone plus metronidazole
16 Effect of Albiglutide, When Added to Standard Blood Glucose Lowering Therapies, on Major Cardiovascular Events in Subjects With Type 2 Diabetes Mellitus Completed NCT02465515 Phase 4
17 Initial Non-operative Treatment Strategy Versus Appendectomy Treatment Strategy for Simple Appendicitis in Children Recruiting NCT02848820 Phase 4 Augmentin + Gentamicin
18 A Trial to Assess the Efficacy and Safety of Morinidazole in Patients With Appendicitis Recruiting NCT03380793 Phase 4 morinidazole
19 Wound Infiltration With Local Anesthetic Agent for Laparoscopic Appendectomy in Adult Recruiting NCT03481517 Phase 4 Bupivacaine
20 Intravenous Lidocaine in Children Undergoing Laparoscopic Appendectomy Recruiting NCT03886896 Phase 4 Lidocaine
21 COMPARISON OF TRANSVERSUS ABDOMINIS PLANE BLOCK, LOCAL ANESTHETIC INJECTION TO THE PORT SITES AND INTRAPERITONEAL LOCAL ANESTHESIA APPLICATIONS IN POSTOPERATIVE PAIN MANAGEMENT IN PATIENTS WITH LAPAROSCOPIC APPENDECTOMY Active, not recruiting NCT03790020 Phase 4 Bupivacaine
22 Antibiotic Duration in Post-appendectomy Abscess Not yet recruiting NCT03795194 Phase 4 ampicillin/clavulanate
23 A Study Comparing Safety and Efficacy of Levofloxacin and Metronidazole Versus Piperacillin/Tazobactam in Treating Complicated Appendicitis Terminated NCT00236912 Phase 4 levofloxacin; metronidazole
24 Study Comparing Early Laparoscopy With Active Observation in Acute Non-specific Abdominal Pain Terminated NCT01675466 Phase 4
25 Once Daily Metronidazole for Perforated Appendicitis Withdrawn NCT02561117 Phase 4 Metronidazole
26 Laparoscopic Appendectomy by Multi-port vs Single Port. Unknown status NCT01720082 Phase 3
27 The Onset Time of Rocuronium in Emergency and Elective Surgery Unknown status NCT02634255 Phase 3 Rocuronium elective surgery;Rocuronium emergency surgery;Propofol;Fentanyl
28 Feasibility of Outpatient Appendectomy for Acute Appendicitis Completed NCT01839435 Phase 3
29 Early Versus Interval Appendectomy for Ruptured Appendicitis in Children Completed NCT00435032 Phase 3
30 Efficacy Study of Delayed Primary Closure to Reduce Rate of Wound Infection in Complicated Appendicitis Completed NCT01659983 Phase 3
31 Diagnosis of Acute Appendicitis: Low-dose Computed Tomography (CT) Versus Standard-dose CT Completed NCT00913380 Phase 3
32 Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures Completed NCT01524081 Phase 3 Metronidazole, Cefuroxime;Amoxicillin (+ clavulanic acid) and Fluconazole;Placebo;Placebo
33 Laparoscopic Appendectomy for Chronic Right Lower Abdominal Pain Completed NCT00413855 Phase 3
34 Single Incision Versus Conventional Laparoscopic Appendectomy Completed NCT01515293 Phase 3
35 A Randomised Controlled Trial on LESS Versus Conventional Laparoscopic Appendicectomy. Completed NCT01203566 Phase 3
36 Efficacy and Safety Study of Eravacycline Compared With Meropenem in Complicated Intra-abdominal Infections Completed NCT02784704 Phase 3 Eravacycline;Meropenem;Placebo
37 Doripenem in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00229060 Phase 3 doripenem
38 Doripenem in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00210938 Phase 3 Doripenem
39 Sublingual Analgesia for Acute Abdominal Pain in Children Completed NCT02465255 Phase 3 Ketorolac;Tramadol;Acetaminophen
40 Safety and Efficacy of Albiglutide + Insulin Glargine Versus Insulin Lispro + Insulin Glargine Subjects With Type 2 Diabetes Mellitus Completed NCT02229227 Phase 3 Albiglutide;Insulin Glargine and Insulin Lispro
41 The Value of Post-operative Antibiotic Therapy After Laparoscopic Appendectomy for Complicated Acute Appendicitis (Other Than for Generalized Peritonitis) Not yet recruiting NCT03688295 Phase 3 Antibiotics
42 A Safety and Tolerability Study of Doripenem Compared With Meropenem in Children Hospitalized With Complicated Intra-abdominal Infections Terminated NCT01110382 Phase 3 Doripenem;Meropenem placebo;Meropenem;Doripenem placebo;Amoxicillin/clavulanate potassium
43 Clinical Trial Comparing ERAT vs Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis Unknown status NCT02789865 Phase 2 Ertapenem, Levofloxacin and Metronidazole
44 Nebulized Analgesia for Laparoscopic Appendectomy Trial Unknown status NCT02624089 Phase 1, Phase 2 Ropivacaine;Normal saline
45 Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis Completed NCT02664220 Phase 2 Povidone-iodine irrigation
46 Study of Conservative Versus Surgical Treatment of Appendicitis Completed NCT00469430 Phase 2 cefotaxim and metronidazol
47 The Safety and Pharmacokinetics of Intraperitoneal Administration in Patients Undergoing Appendectomy for Uncomplicated Appendicitis Completed NCT03046758 Phase 2 A combination of fosfomycin, metronidazole and GM-CSF i.p.
48 Intraperitoneal Administration of Fosfomycin, Metronidazole and Molgramostim Versus Intravenous Antibiotics for Perforated Appendicitis Completed NCT03435900 Phase 2 Combination of fosfomycin, metronidazole and rhGM-CSF (administered together intraperitoneally) and three days of antibiotics p.o.;Standard antibiotics intravenously
49 Preoperative Methylprednisolone to Patients Suspected of Appendicitis Undergoing Laparoscopy Completed NCT02711449 Phase 2 Methylprednisolone;0.9% Saline
50 Dexamethasone Preoperative for Patients Undergoing Laparoscopy for Suspected Appendicitis Completed NCT02415335 Phase 2 dexamethasone phosphate;Isotonic NaCl

Search NIH Clinical Center for Appendicitis

Cochrane evidence based reviews: appendicitis

Sources

Genetic Tests for Appendicitis

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Sources

Anatomical Context for Appendicitis

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MalaCards organs/tissues related to Appendicitis:

42
Appendix, Colon, Testes, Kidney, Lung, Liver, Neutrophil
Sources

Publications for Appendicitis

About this section

Articles related to Appendicitis:

(show top 50) (show all 5011)
# Title Authors Year
1
Impact of co-amoxicillin-resistant Escherichia coli and Pseudomonas aeruginosa on the rate of infectious complications in paediatric complicated appendicitis. ( 31026042 )
2019
2
Streptococcus pneumoniae primary peritonitis mimicking acute appendicitis in an immunocompetent patient: a case report and review of the literature. ( 31029142 )
2019
3
Surgical treatment of acute appendicitis in older patients. ( 31032807 )
2019
4
Acute appendicitis and Enterobius vermicularis infestation. ( 31036611 )
2019
5
Risk for appendicitis, cholecystitis, or diverticulitis in patients with psoriasis. ( 31039227 )
2019
6
Complicated and Uncomplicated Acute Appendicitis Are Different Diseases-Do Not Compare Apples With Oranges-Reply. ( 31042276 )
2019
7
Complicated and Uncomplicated Acute Appendicitis Are Different Diseases-Do Not Compare Apples With Oranges. ( 31042279 )
2019
8
Use of the Alvarado Score in Elderly Patients with Complicated and Uncomplicated Appendicitis. ( 31043201 )
2019
9
Utilization of a specimen retrieval bag during laparoscopic appendectomy for both uncomplicated and complicated appendicitis is not associated with a decrease in postoperative surgical site infection rates. ( 31043235 )
2019
10
ACR Appropriateness Criteria® Suspected Appendicitis-Child. ( 31054752 )
2019
11
Neutrophil-to-lymphocyte ratio predicts acute appendicitis and distinguishes between complicated and uncomplicated appendicitis: A systematic review and meta-analysis. ( 31056211 )
2019
12
MRI for Pediatric Appendicitis in an Adult-Focused General Hospital: A Clinical Effectiveness Study-Challenges and Lessons Learned. ( 30383407 )
2019
13
The contemporary appendectomy for acute uncomplicated appendicitis in adults. ( 30385123 )
2019
14
A novel noninvasive appendicitis score with a urine biomarker. ( 30391151 )
2019
15
Genetic association and differential expression of PITX2 with acute appendicitis. ( 30392061 )
2019
16
Clinical recovery in children with uncomplicated appendicitis undergoing non-operative treatment: secondary analysis of a prospective cohort study. ( 30421265 )
2019
17
A simple algorithm to improve quality while reducing resource utilization in evaluation of suspected appendicitis in children. ( 30454838 )
2019
18
Mean platelet volume and the ratio of mean platelet volume to platelet count in the diagnosis of acute appendicitis. ( 29866415 )
2019
19
Suspicion of appendicitis in pregnant women: emergency evaluation by sonography and low-dose CT with oral contrast. ( 29948087 )
2019
20
Evaluating a Health Care Disparity Among Marine Recruits Treated for Acute Appendicitis. ( 29982574 )
2019
21
Target sign: appendicitis. ( 29987400 )
2019
22
Enhanced recovery after surgery protocol allows ambulatory laparoscopic appendectomy in uncomplicated acute appendicitis: a prospective, randomized trial. ( 29987566 )
2019
23
Current View on the Nonoperative Management of Acute Appendicitis in a County Hospital in Guatemala. ( 29605401 )
2019
24
Patient-Specific and Hospital Resource-Specific Considerations in Operative Versus Nonoperative Management of Acute Appendicitis. ( 29622400 )
2019
25
Pediatric subhepatic appendicitis with elevated lipase. ( 30361147 )
2019
26
Luminal obstruction in uncomplicated appendicitis: Detection with sonography and potential clinical implications. ( 30350372 )
2019
27
Identification of New Potential Therapies for Colitis Amelioration Using an Appendicitis-Appendectomy Model. ( 30329049 )
2019
28
Twenty-four hour versus extended antibiotic administration after surgery in complicated appendicitis: A randomized controlled trial. ( 30308538 )
2019
29
Suspicion of acute appendicitis in adults. The value of ultrasound in our hospital. ( 30290969 )
2019
30
Logistic regression model to predict acute uncomplicated and complicated appendicitis. ( 30286649 )
2019
31
Variation in Classification and Postoperative Management of Complex Appendicitis: A European Survey. ( 30255334 )
2019
32
Current Trends in Training in the Surgical Management of Acute Appendicitis at a Veteran Affairs Hospital. ( 30249516 )
2019
33
European Paediatric Surgeons' Association Survey on the Management of Pediatric Appendicitis. ( 30112745 )
2019
34
Low mitochondrial DNA copy number of resected cecum appendix correlates with high severity of acute appendicitis. ( 30100165 )
2019
35
Conical ultrashort echo time (UTE) MRI in the evaluation of pediatric acute appendicitis. ( 30066168 )
2019
36
Appendiceal diverticulitis as a cause of acute appendicitis. ( 30031549 )
2019
37
Diagnostic performance of emergency physician-performed point-of-care ultrasonography for acute appendicitis: A meta-analysis. ( 30017693 )
2019
38
Improving the value of ultrasound in children with suspected appendicitis: a prospective study integrating secondary sonographic signs. ( 30016853 )
2019
39
Acute appendicitis - new diagnostic algorithm using RIPASA score and non-contrast Computeed Tomography Scan. ( 30697011 )
2019
40
Irrigation Versus Suction in Laparoscopic Appendectomy for Complicated Appendicitis: A Meta-analysis. ( 30691801 )
2019
41
Comparison of conservative versus surgical therapy for acute appendicitis with abscess in five German hospitals. ( 30671634 )
2019
42
Accuracy of clinician gestalt in diagnosing appendicitis in children presenting to the emergency department. ( 30665265 )
2019
43
The fecal and mucosal microbiome in acute appendicitis patients: an observational study. ( 30663346 )
2019
44
Beyond appendicitis: ultrasound findings of acute bowel pathology. ( 30661212 )
2019
45
Could infrared thermal imaging be a new diagnostic tool for acute appendicitis? ( 30659787 )
2019
46
Pentraxin-3: A strong novel biochemical marker for appendicitis in children. ( 30658876 )
2019
47
Α very rare case of De Garengeot's hernia: Acute appendicitis within a femoral hernia. ( 30656015 )
2019
48
Is early appendectomy in adults diagnosed with acute appendicitis mandatory? A prospective study. ( 30651750 )
2019
49
In uncomplicated acute appendicitis, 61% of patients initially treated with antibiotics had not had appendectomy at 5 years. ( 30641561 )
2019
50
Evaluation of white blood cell count at time of discharge is associated with limited oral antibiotic therapy in children with complicated appendicitis. ( 30639131 )
2019
Sources

Variations for Appendicitis

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Expression for Appendicitis

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Search GEO for disease gene expression data for Appendicitis.
Sources

Pathways for Appendicitis

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Pathways related to Appendicitis according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.98 CRP CXCL8 HMGB1 IL10 IL1B IL6
2
Cytokine Signaling in Immune system 67
Show member pathways
 13.35 CXCL8 IL10 IL1B IL6 LBP MMP9
3
PAK Pathway 65
Show member pathways
 13.27 CXCL8 IL10 IL1B IL6 TIMP1 TNF
4
Toll-like Receptor Signaling Pathway 1 38
Show member pathways
 13.11 CXCL8 IL10 IL1B IL6 LBP TNF
5
Allograft rejection 38 1
Show member pathways
 12.86 CXCL8 IL10 IL1B IL6 TNF
6
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 67
Show member pathways
 12.77 CXCL8 HMGB1 IL1B IL6 TNF
7
Immune response IL-23 signaling pathway 23
Show member pathways
 12.58 IL10 IL1B IL6 MPO TIMP1 TNF
8
Th17 cell differentiation 38
Show member pathways
 12.57 IL10 IL1B IL6 TNF
9
T cell receptor signaling pathway 38
Show member pathways
 12.55 IL10 IL1B IL6 TNF
10
NF-kappaB Signaling 4
12.54 IL10 IL1B MPO TNF
11
IL-17 Family Signaling Pathways 66
Show member pathways
 12.36 CXCL8 IL1B IL6 MMP9 TNF
12
Toll Comparative Pathway 65
Show member pathways
 12.35 CXCL8 IL1B IL6 LBP TNF
13
Selenium Micronutrient Network 1
Show member pathways
 12.29 ALB CRP IL1B IL6 MPO TNF
14
Transcriptional misregulation in cancer 38
12.27 CXCL8 IL6 MMP9 MPO
15
Tuberculosis 38
12.26 IL10 IL1B IL6 LBP TNF
16
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.26 CXCL8 IL10 IL1B IL6 TIMP1 TNF
17
IL-1 Family Signaling Pathways 66
Show member pathways
 12.25 CXCL8 IL1B IL6 TNF
18
C-type lectin receptor signaling pathway 38
Show member pathways
 12.24 IL10 IL1B IL6 TNF
19
Bacterial infections in CF airways 23
Show member pathways
 12.21 CXCL8 IL1B IL6 LBP TNF
20
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.2 CXCL8 IL10 IL1B IL6 TNF
21
Immune response IFN gamma signaling pathway 23
Show member pathways
 12.1 CXCL8 IL10 IL1B IL6 TIMP1
22
Th1 Differentiation Pathway 66
Show member pathways
 12.1 IL10 IL1B IL6 TNF
23
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 12.06 HMGB1 IL1B IL6 MMP9 TNF
24
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
12.04 IL10 IL6 MPO TNF
25
Spinal Cord Injury 1
12.02 CXCL8 IL1B IL6 MMP9 TNF
26
TNF signaling pathway 38
12.01 IL1B IL6 MMP9 TNF
27
AGE-RAGE signaling pathway in diabetic complications 38
11.96 CXCL8 IL1B IL6 TNF
28
Matrix Metalloproteinases 1
Show member pathways
 11.96 MMP8 MMP9 TIMP1 TNF
29
NF-kappa B signaling pathway 38
11.95 CXCL8 IL1B LBP TNF
30
Senescence and Autophagy in Cancer 1
11.93 CXCL8 IL1B IL6
31
Rheumatoid arthritis 38
11.91 CXCL8 IL1B IL6 TNF
32
HIF-1 signaling pathway 38
11.9 ENO2 IL6 TIMP1
33
Hematopoietic cell lineage 38
11.88 IL1B IL6 TNF
34
Salmonella infection (KEGG) 38
11.87 CXCL8 IL1B IL6 LBP
35
Amoebiasis 38
11.87 CXCL8 IL10 IL1B IL6 TNF
36
Cytokine production by Th17 cells in CF (Mouse model) 23
Show member pathways
 11.86 CXCL8 IL6 LBP
37
Innate Lymphoid Cell Differentiation Pathways 66
11.79 IL10 IL1B TNF
38
Regulation of Wnt-mediated beta catenin signaling and target gene transcription 1
11.79 CXCL8 MMP9 PITX2
39
Dendritic Cells Developmental Lineage Pathway 66
11.79 IL10 IL1B IL6 TNF
40
Pertussis 38
11.74 CXCL8 IL10 IL1B IL6 TNF
41
LPA receptor mediated events 1
11.7 CXCL8 IL6 MMP9
42
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.68 IL10 IL1B IL6 MMP9 TNF
43
Cell adhesion_ECM remodeling 23
11.67 CXCL8 MMP9 TIMP1
44
Legionellosis 38
11.63 CXCL8 IL1B IL6 TNF
45
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.57 CXCL8 IL1B IL6 MMP9 TNF
46
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.52 IL1B IL6 TNF
47
Lung fibrosis 1
11.43 CXCL8 IL1B IL6 MMP9 TIMP1 TNF
48
African trypanosomiasis 38
11.41 IL10 IL1B IL6 TNF
49
Malaria 38
11.41 CXCL8 IL10 IL1B IL6 TNF
50
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.4 CXCL8 IL6 MMP9
Sources

GO Terms for Appendicitis

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Cellular components related to Appendicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 ALB CRP CXCL8 HMGB1 IL10 IL1B
2 extracellular space GO:0005615 9.47 ALB CRP CXCL8 ENO2 HMGB1 IL10

Biological processes related to Appendicitis according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.99 IL10 LBP MPO TNF
2 regulation of signaling receptor activity GO:0010469 9.98 CXCL8 HMGB1 IL10 IL1B IL6 TIMP1
3 inflammatory response GO:0006954 9.95 CRP CXCL8 HMGB1 IL10 IL1B IL6
4 response to lipopolysaccharide GO:0032496 9.94 IL10 IL1B LBP MPO
5 response to organic substance GO:0010033 9.88 IL10 TIMP1 TNF
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.88 IL10 IL1B IL6 TNF
7 extracellular matrix disassembly GO:0022617 9.85 MMP8 MMP9 TIMP1
8 defense response to Gram-positive bacterium GO:0050830 9.85 CRP IL6 LBP TNF
9 positive regulation of protein phosphorylation GO:0001934 9.83 IL1B MMP9 TNF
10 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.83 IL10 MMP9 TNF
11 positive regulation of JNK cascade GO:0046330 9.83 HMGB1 IL1B MMP8 TNF
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 IL1B MMP8 TNF
13 cellular response to lipopolysaccharide GO:0071222 9.8 CXCL8 IL10 IL1B IL6 LBP TNF
14 acute-phase response GO:0006953 9.79 CRP IL6 LBP
15 lipopolysaccharide-mediated signaling pathway GO:0031663 9.78 IL1B LBP TNF
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.78 HMGB1 IL1B MMP8 TNF
17 positive regulation of DNA binding GO:0043388 9.77 HMGB1 MMP8 MMP9
18 positive regulation of interleukin-8 production GO:0032757 9.77 IL1B LBP TNF
19 negative regulation of neurogenesis GO:0050768 9.74 IL1B IL6 TNF
20 embryonic digestive tract development GO:0048566 9.72 CXCL8 TNF
21 negative regulation of lipid catabolic process GO:0050995 9.72 IL1B TNF
22 positive regulation of macrophage activation GO:0043032 9.72 IL10 LBP
23 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.72 IL1B TNF
24 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IL1B TNF
25 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 IL10
26 positive regulation of chemokine production GO:0032722 9.71 IL6 LBP TNF
27 opsonization GO:0008228 9.7 CRP LBP
28 endothelial cell apoptotic process GO:0072577 9.69 IL10 TNF
29 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.69 IL10 TIMP1
30 positive regulation of glial cell proliferation GO:0060252 9.69 IL1B IL6 TNF
31 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
32 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
33 negative regulation of cytokine secretion involved in immune response GO:0002740 9.67 IL10 TNF
34 positive regulation of fever generation GO:0031622 9.67 IL1B TNF
35 regulation of neuroinflammatory response GO:0150077 9.67 MMP8 MMP9
36 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.67 IL10 IL1B TNF
37 positive regulation of tumor necrosis factor production GO:0032760 9.66 HMGB1 LBP
38 sequestering of triglyceride GO:0030730 9.64 IL1B TNF
39 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.63 IL1B TNF
40 negative regulation of lipid storage GO:0010888 9.63 CRP IL6 TNF
41 receptor biosynthetic process GO:0032800 9.62 IL10 TNF
42 regulation of microglial cell activation GO:1903978 9.62 MMP8 TNF
43 positive regulation of neutrophil chemotaxis GO:0090023 9.56 CXCL8 LBP
44 negative regulation of growth of symbiont in host GO:0044130 9.56 IL10 LBP MPO TNF
45 cytokine-mediated signaling pathway GO:0019221 9.56 CXCL8 IL10 IL1B IL6 LBP MMP9
46 response to glucocorticoid GO:0051384 9.54 IL10 IL6 TNF
47 positive regulation of neuroinflammatory response GO:0150078 9.46 IL1B IL6 MMP8 TNF
48 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.4 IL1B
49 macrophage activation involved in immune response GO:0002281 9.4 LBP
50 positive regulation of toll-like receptor 4 signaling pathway GO:0034145 9.4 LBP

Molecular functions related to Appendicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CXCL8 HMGB1 IL10 IL1B IL6 TIMP1
Sources

Sources for Appendicitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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