MCID: APP008
MIFTS: 65

Appendicitis

Categories: Gastrointestinal diseases
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Aliases & Classifications for Appendicitis

MalaCards integrated aliases for Appendicitis:

Name: Appendicitis 11 75 53 5 41 43 14 16 71 33
Acute Appendicitis 11 53 14 31 33
Acute Appendicitis with Generalized Peritonitis 11 31
Acute Appendicitis Nos 71 33
Acute Appendicitis with Perforation and Contained Peritonitis into an Abscess 33
Acute Appendicitis with Diffuse Peritonitis Following Rupture or Perforation 33
Acute Appendicitis with Localised Peritonitis Without Rupture or Perforation 33
Acute Appendicitis with Localised Peritonitis with Rupture or Perforation 33
Acute Appendicitis with Contained Perforation to a Localised Abscess 33
Acute Appendicitis with No Perforation or Abscess and No Visible Pus 33
Appendicitis with Perforation and Free Pus in the Peritoneal Cavity 33
Acute Appendicitis with Free Perforation to the Abdominal Cavity 33
Acute Appendicitis with No Specification if Perforated or Not 33
Perforated Appendix with Generalised Peritonitis 33
Perforated Appendix with Localised Peritonitis 33
Acute Appendicitis with Peritoneal Abscess 11
Acute Appendicitis with Free Peritonitis 33
Appendicitis with Peritoneal Abscess 33
Acute Appendicitis with Phlegmone 33
Acute Appendix Inflammation 33
Appendicitis, Unqualified 33
Appendicitis with Abscess 33
Appendiceal Inflammation 33
Ruptured Appendix Nos 33

Classifications:



External Ids:

Disease Ontology 11 DOID:8337
ICD9CM 34 540-543.99
MeSH 43 D001064
NCIt 49 C35145
SNOMED-CT 68 155729003
UMLS 71 C0003615 C0085693

Summaries for Appendicitis

MedlinePlus: 41 The appendix is a small, tube-like organ attached to the first part of the large intestine. It is located in the lower right part of the abdomen. It has no known function. A blockage inside of the appendix causes appendicitis. The blockage leads to increased pressure, problems with blood flow, and inflammation. If the blockage is not treated, the appendix can burst and spread infection into the abdomen. This causes a condition called peritonitis. The main symptom is pain in the abdomen, often on the right side. It is usually sudden and gets worse over time. Other symptoms may include: Swelling in the abdomen Loss of appetite Nausea and vomiting Constipation or diarrhea Inability to pass gas Low fever Not everyone with appendicitis has all these symptoms. Appendicitis is a medical emergency. Treatment almost always involves removing the appendix. Anyone can get appendicitis, but it is more common among people 10 to 30 years old. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary: Appendicitis, also known as acute appendicitis, is related to neutrophilia, hereditary and inguinal hernia, and has symptoms including pain, nausea and vomiting. An important gene associated with Appendicitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Aztreonam and Ropivacaine have been mentioned in the context of this disorder. Affiliated tissues include appendix, kidney and colon, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology: 11 A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has symptom pain, in the upper abdomen initially and later in the lower abdomen, has symptom nausea, has symptom vomiting and has symptom fever.

Wikipedia: 75 Appendicitis is inflammation of the appendix. Symptoms commonly include right lower abdominal pain,... more...

Related Diseases for Appendicitis

Diseases related to Appendicitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1447)
# Related Disease Score Top Affiliating Genes
1 neutrophilia, hereditary 31.4 MPO IL6 CSF3 CRP
2 inguinal hernia 31.4 MMP9 IL6 CRP ALB
3 intussusception 31.3 IL6 CRP ALB
4 intestinal obstruction 31.3 TNF IL6 CRP ALB
5 cholecystitis 31.3 TLR4 CRP ALB
6 diverticulitis 31.3 TNF S100A9 MMP9 IL6 CRP ALB
7 mesenteric lymphadenitis 31.1 TNF IL6 IL1B CRP ALB
8 paralytic ileus 30.9 IL6 CRP ALB
9 actinomycosis 30.9 TNF IL10 CRP ALB
10 measles 30.8 TLR4 IL6 IL2 IL1B
11 pleural empyema 30.8 IL6 CRP ALB
12 enterocolitis 30.8 TNF TLR4 IL6 IL10 CXCL8 CRP
13 ileus 30.8 TNF IL6 IL1B IL17A IL10 IFNG
14 endometriosis 30.8 IL6 IL1B CXCL8 CCL2
15 clostridium difficile colitis 30.7 IL1B CRP ALB
16 constipation 30.6 TNF IL6 IL1B IL10 CRP ALB
17 inflammatory bowel disease 1 30.6 TNF TLR4 IL6 IL1B IL17A IL10
18 fasciitis 30.6 TNF IL6 IL2 IFNG CXCL8
19 necrotizing fasciitis 30.6 TNF IL6 IL1B CXCL8 CRP ALB
20 peptic ulcer perforation 30.6 CRP ALB
21 intestinal perforation 30.6 TNF IL6 IL10 CRP ALB
22 pain agnosia 30.5 TNF IL6 IL1B IL10 CRP ALB
23 testicular torsion 30.5 TNF MPO IL1B CRP
24 henoch-schoenlein purpura 30.5 TNF MPO IL6 CRP ALB
25 lymphadenitis 30.5 TNF TLR4 PTX3 IL6 IL1B IL10
26 adult syndrome 30.5 TNF IL6 CRP
27 ileitis 30.5 TNF TLR4 MPO IL6 IL17A IL10
28 pfeiffer syndrome 30.5 TNF IL2 IL10 CRP
29 pyuria 30.5 LCN2 IL6 CRP ALB
30 paine syndrome 30.5 TNF IL6 IL1B IL10 CXCL8
31 salpingitis 30.4 TNF TLR4 IL6 IL1B IL10 CXCL8
32 typhoid fever 30.4 TNF TLR4 IL6 IL1B IFNG CRP
33 cysticercosis 30.4 TLR4 IL6 IL1B IL10
34 intestinal tuberculosis 30.4 TNF IFNG CRP ALB
35 cardiac tamponade 30.4 IL6 CRP ALB
36 acute kidney failure 30.4 LCN2 IL6 ALB
37 gastrointestinal tuberculosis 30.4 TNF IFNG CRP ALB
38 peptic ulcer disease 30.3 TNF IL6 IL1B IL10 CXCL8 CRP
39 pouchitis 30.3 TNF TLR4 S100A9
40 kawasaki disease 30.3 TNF S100A9 MMP9 CRP CCL2
41 sickle cell anemia 30.3 TNF IL6 CSF3 CRP ALB
42 polyarteritis nodosa 30.3 TNF MPO IL6 CRP
43 pericardial effusion 30.3 TNF IL6 CRP ALB
44 dengue disease 30.3 TNF IL6 IL10 CXCL8 ALB
45 hypereosinophilic syndrome 30.3 MPO IL2 IL10 IFNG CXCL8
46 intestinal schistosomiasis 30.3 IL2 IL17A IL10
47 anuria 30.2 LCN2 CRP ALB
48 epidemic typhus 30.2 IL10 CRP ALB
49 amyloidosis 30.2 TNF IL6 IL1B CRP ALB
50 hydronephrosis 30.2 MMP9 LCN2 IL6 CXCL8 CRP CCL2

Graphical network of the top 20 diseases related to Appendicitis:



Diseases related to Appendicitis

Symptoms & Phenotypes for Appendicitis

Symptoms:

11
  • pain
  • nausea
  • vomiting
  • fever

UMLS symptoms related to Appendicitis:


abdominal pain; constipation; diarrhea; dyspepsia; heartburn; icterus; nausea and vomiting; gastrointestinal gas

GenomeRNAi Phenotypes related to Appendicitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 10.33 CXCL8 IL10 IL17A IL1B LCN2 MPO
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 10.33 CXCL8 IL10 IL17A IL1B IL2 LCN2
3 no effect GR00402-S-1 10.15 ALB CCL2 CRP CSF3 CXCL8 IFNG
4 no effect GR00402-S-2 10.15 ALB CCL2 CRP CSF3 IFNG IL10
5 Reduced mammosphere formation GR00396-S 9.5 ALB CCL2 CSF3 CXCL8 IL17A LCN2

MGI Mouse Phenotypes related to Appendicitis:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.36 ALB CCL2 CRP IFNG IL10 IL17A
2 immune system MP:0005387 10.28 ALB CCL2 CRP CSF3 IFNG IL10
3 neoplasm MP:0002006 10.25 ALB CCL2 IFNG IL10 IL1B IL2
4 liver/biliary system MP:0005370 10.22 ALB CCL2 IFNG IL10 IL17A IL2
5 cellular MP:0005384 10.18 ALB CCL2 IFNG IL10 IL2 IL6
6 cardiovascular system MP:0005385 10.18 ALB CCL2 CRP IFNG IL10 IL1B
7 muscle MP:0005369 10.15 ALB CCL2 IFNG IL10 IL6 MMP9
8 digestive/alimentary MP:0005381 10.13 ALB CCL2 IFNG IL10 IL17A IL2
9 hematopoietic system MP:0005397 10.06 CCL2 CSF3 IFNG IL10 IL17A IL1B
10 respiratory system MP:0005388 9.91 IFNG IL10 IL17A IL2 IL6 MMP9
11 mortality/aging MP:0010768 9.8 ALB CCL2 IFNG IL10 IL17A IL1B
12 integument MP:0010771 9.32 CCL2 CSF3 IFNG IL10 IL17A IL1B

Drugs & Therapeutics for Appendicitis

Drugs for Appendicitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 152)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aztreonam Approved Phase 4 78110-38-0 5742832
2
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
3
Ceftriaxone Approved Phase 4 73384-59-5 5479530
4
Nabumetone Approved Phase 4 42924-53-8 4409
5
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
6
Tigecycline Approved Phase 4 220620-09-7 5282044
7
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
8
Nalbuphine Approved Phase 4 20594-83-6 5311304
9
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
10
Cefuroxime Approved Phase 4 55268-75-2 5479529
11
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
12
Povidone-iodine Approved Phase 4 25655-41-8
13
Povidone K30 Approved, Experimental Phase 4 9003-39-8 6917 131751496
14
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456 5824
15
Glycopyrronium Approved, Investigational, Vet_approved Phase 4 596-51-0, 740028-90-4 3494
16
Tazobactam Approved Phase 4 89786-04-9 123630
17
Piperacillin Approved Phase 4 66258-76-2 43672
18
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
19
Ofloxacin Approved Phase 4 82419-36-1 4583
20
Clavulanic acid Approved, Vet_approved Phase 4 58001-44-8 5280980
21
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
22
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
23 Analgesics Phase 4
24 Cyclooxygenase Inhibitors Phase 4
25 Antirheumatic Agents Phase 4
26 Anti-Inflammatory Agents, Non-Steroidal Phase 4
27 Analgesics, Non-Narcotic Phase 4
28 Anti-Inflammatory Agents Phase 4
29 Cyclooxygenase 2 Inhibitors Phase 4
30 Gentamicins Phase 4
31
Cefuroxime axetil Phase 4 3379942
32 Antitubercular Agents Phase 4
33 Sodium Channel Blockers Phase 4
34 Anti-Arrhythmia Agents Phase 4
35 Diuretics, Potassium Sparing Phase 4
36 Neurotransmitter Agents Phase 4
37 Hemostatics Phase 4
38 Muscarinic Antagonists Phase 4
39 Cholinesterase Inhibitors Phase 4
40 Cholinergic Antagonists Phase 4
41 Cholinergic Agents Phase 4
42 Amoxicillin-Potassium Clavulanate Combination Phase 4
43 Cytochrome P-450 Enzyme Inhibitors Phase 4
44
Rocuronium Approved Phase 3 119302-91-9, 143558-00-3 441290
45
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943
46
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
47
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
48
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
49
Ketorolac Approved Phase 3 74103-06-3, 66635-83-4 3826
50
Morphine Approved, Investigational Phase 3 57-27-2 5288826

Interventional clinical trials:

(show top 50) (show all 316)
# Name Status NCT ID Phase Drugs
1 Antibiotics vs.Surgery in Acute Appendicitis;an Intention to Treat Prospective Randomised Study. The ASAA-study Unknown status NCT01421901 Phase 4 Ertapenem
2 An Open-Lable Multicenter Prospective Non-Randomized Trial to Assess the Efficacy and Safety of Morinidazole With Surgery in Patients With Suppurative or Gangrenous Appendicitis Unknown status NCT03380793 Phase 4 morinidazole
3 Effect of Pain Control on the Diagnosis of Acute Appendicitis on the Diagnostic Accuracy of General Surgeon Completed NCT00783016 Phase 4 Morphine
4 Comparison of Medical and Surgical Treatment of Uncomplicated Acute Appendicitis in Children Completed NCT02991937 Phase 4 Piperacillin/Tazobactam
5 Double Blind Randomized Study of Morphine Analgesia in Patients With Acute Appendicitis Completed NCT00477061 Phase 4 Morphine
6 Non Operative Treatment for Acute Appendicitis: Study on Efficacy and Safety of Antibiotic Treatment (Amoxicillin and Clavulanic Acid) in Patients With Right Sided Lower Abdominal Pain Completed NCT01096927 Phase 4 Amoxicillin and Clavulanic Acid
7 Optimized Treatment for Uncomplicated Acute Appendicitis; Active Observation With or Without Antibiotic Treatment Completed NCT03985514 Phase 4 Antibiotic treatment (Piperacillin/Tazobactam, 4 gram x 3), followed by 8-10 days of out-hospital oral antibiotic treatment (Ciprofloxacin 500 mgx2,Flagyl 400 mgx3).
8 Safety and Efficacy of Single Daily Dose of Ceftriaxone and Metronidazole for Treatment of Complicated Appendicitis in Children Completed NCT01678365 Phase 4 ceftriaxone, metronidazole/ampicillin, gentamicin, and metronidazole
9 A Randomized Comparison of Ultrasound Guided Bilateral Rectus Sheath Block and Local Anesthetic Infiltration for Postoperative Pain Control in Children With Acute Appendicitis Completed NCT02352519 Phase 4
10 Choose Between Two Different Concentration of Ropivacaine on TAP Block for Children Submitted of Open Appendectomy Completed NCT03005808 Phase 4 Ropivacaine
11 The Interest of Wound Infiltration With Local Anesthetic Agent for Laparoscopic Appendectomy in Adult: a Double Blind, Prospective, Randomized Control Trial Completed NCT03481517 Phase 4 Bupivacaine
12 Comparison Between Intradermic vs Habitual Skin Closure Technique in Open Appendicectomy. Completed NCT02625987 Phase 4
13 A Multicenter, Open-Label, Randomized Comparative Study of Tigecycline vs Ceftriaxone Sodium Plus Metronidazole for the Treatment of Hospitalized Subjects With Complicated Intra-abdominal Infection Completed NCT00230971 Phase 4 tigecycline;ceftriaxone plus metronidazole
14 A Multicenter, Open-Label, Randomized Comparative Study of Tigecycline vs Ceftriaxone Sodium Plus Metronidazole for the Treatment of Hospitalized Subjects With Complicated Intra-abdominal Infection Completed NCT00195351 Phase 4 tigecycline;ceftriaxone sodium + metronidazole
15 Wound Healing and Cosmetic Result After Emergency Appendicectomy in Adult Patients: a Prospective, Randomised Trial Comparing Two Methods of Wound Closure Completed NCT00913445 Phase 4
16 Efficacy of Intravenous Lidocaine Infusion on Pain Relief in Children Undergoing Laparoscopic Appendectomy: Randomized Controlled Trial. Completed NCT03886896 Phase 4 Lidocaine
17 Pain Post Abdominal Laparoscopy Prevention With Arcoxia Completed NCT00565682 Phase 4 etoricoxib 120 mg
18 Laparoscopic Versus Open Appendectomy: A Retrospective Cohort Study Assessing Outcomes and Cost-effectiveness Completed NCT02867072 Phase 4
19 Initial Non-operative Treatment Strategy Versus Appendectomy Treatment Strategy for Simple Appendicitis in Children Aged 7-17 Years Old - Antibiotics Versus Primary Appendectomy in Children With Simple Appendicitis: APAC Study Recruiting NCT02848820 Phase 4 Augmentin + Gentamicin
20 Role of Delay and Antibiotics on PERForation Rate While Waiting appendECTomy - Randomized Non-inferiority Trial Recruiting NCT04378868 Phase 4 Antibiotics, cefuroxime and metronidazole;No antibiotics
21 The Effect of Intravenous Lidocaine Infusion on Hemodynamic Reaction to Tracheal Intubation, as Well as Metabolic and Hormonal Response to Laparoscopic Procedure in Children: a Randomized Controlled Trial Recruiting NCT05238506 Phase 4 Intravenous lidocaine;Normal saline infusion
22 Randomized Control Trial: Two Different Antibiotics Versus One Antibiotic for Pediatric Perforated Appendicitis Active, not recruiting NCT03289351 Phase 4 Piperacillin, Tazobactam Drug Combination
23 Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis Not yet recruiting NCT04200729 Phase 4 Irrigation with PVI
24 Effectiveness of Sugammadex Versus Neostigmine on Neuromuscular Reversal in Pediatric Patients Undergoing Laparoscopic Appendectomy for Acute Appendicitis: A Randomized Controlled Trial Not yet recruiting NCT05256901 Phase 4 Sugammadex;Neostigmine/Glycopyrrolate
25 A Prospective, Randomized Trial of Antibiotic Duration in Post-appendectomy Abscess Terminated NCT03795194 Phase 4 ampicillin/clavulanate
26 A Multi-center, Open-label, Randomized Study to Compare the Safety and Efficacy of Once Daily Levofloxacin Along With Once Daily Metronidazole Versus Piperacillin/Tazobactam in the Treatment of Complicated Appendicitis Terminated NCT00236912 Phase 4 levofloxacin; metronidazole
27 Metronidazole Every 24 Hours as Part of Triple Antibiotic Therapy for Ruptured Appendicitis in Children Managed Operatively (METRO): a Noninferiority Randomized Controlled Trial Withdrawn NCT02561117 Phase 4 Metronidazole
28 The Value of Post-operative Antibiotic Therapy After Laparoscopic Appendectomy for Complicated Acute Appendicitis (Other Than for Generalized Peritonitis): a Prospective, Randomized, Placebo-controlled Phase III Study Unknown status NCT03688295 Phase 3 Antibiotics
29 The Prospective Randomized Comparison of the Onset Time of Rocuronium in Patients Undergoing Emergency and Elective Surgery Unknown status NCT02634255 Phase 3 Rocuronium elective surgery;Rocuronium emergency surgery;Propofol;Fentanyl
30 Randomized Controlled Trial Comparing Single Incision Laparoscopic Appendectomy Versus Standard Three Port Appendectomy in a Selected Cohort of Patients Unknown status NCT01720082 Phase 3
31 Early Versus Interval Appendectomy for Ruptured Appendicitis in Children. Ruptured Appendicitis Pilot Trial (RAPTOR) Completed NCT00435032 Phase 3
32 Phase 3 Study of Antibiotic Prophylaxis Use Prior Emergent Surgery, Because of Acute Appendicitis Completed NCT01524081 Phase 3 Metronidazole, Cefuroxime;Amoxicillin (+ clavulanic acid) and Fluconazole;Placebo
33 Non Operative Treatment With Antibiotics Vs Surgery for Acute Non Perforated Appendicitis in Children: A Randomized Controlled Trial. Completed NCT04030741 Phase 2, Phase 3 Meronem and flagyl
34 PROSPECTIVE EVALUATION OF OUTPATIENT APPENDECTOMY FOR NON COMPLICATED ACUTE APPENDICITIS: Intention-to-treat Study Completed NCT01839435 Phase 3
35 Comparison of Surgical Site Infection Between Delayed Primary Closure Versus Primary Closure in Complicated Appendicitis: A Multicenter Randomized Controlled Trial Completed NCT01659983 Phase 3
36 A Double-blinded Randomised Controlled Trial of Laparoendoscopic Single-site Access (LESS) Versus Conventional Three-port Appendicectomy. Completed NCT01203566 Phase 3
37 Prospective Randomised Study Comparing Single Incision Transumbilical Versus Conventional Laparoscopic Appendectomy Completed NCT01515293 Phase 3
38 A Multicenter, Double-Blind, Randomized, Phase 3 Study of Doripenem Versus Comparator Antibiotic in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00210938 Phase 3 Doripenem
39 A Phase 3, Randomized, Double-Blind, Double-Dummy, Multicenter, Prospective Study to Assess the Efficacy and Safety of Eravacycline Compared With Meropenem in Complicated Intra-abdominal Infections Completed NCT02784704 Phase 3 Eravacycline;Meropenem;Placebo
40 A Multicenter, Double-Blind, Randomized, Phase 3 Study of Doripenem Versus Comparator Antibiotic in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00229060 Phase 3 doripenem
41 Elective Laparoscopic Appendectomy for Chronic Right Lower Abdominal Pain; Outcome of a Prospective Randomized Double-Blind Controlled Surgical Trial Completed NCT00413855 Phase 3
42 Negative Appendectomy Rate Following Low-dose CT vs. Standard-dose CT Completed NCT00913380 Phase 3
43 Intravenous Ketorolac Vs. Morphine In Children Presenting With Suspected Appendicitis: A Pilot Single Center Non Inferiority Randomised Controlled Trial Recruiting NCT04528563 Phase 3 Ketorolac Tromethamine 10 MG/ML;Morphine Sulfate 10Mg/1mL Injection
44 A Prospective, Randomized, Double-Blind, Multicenter Study to Establish the Safety and Tolerability of Doripenem Compared With Meropenem in Hospitalized Children With Complicated Intra-Abdominal Infections Terminated NCT01110382 Phase 3 Doripenem;Meropenem placebo;Meropenem;Doripenem placebo;Amoxicillin/clavulanate potassium
45 Multicenter Prospective Randomized Clinical Trial Comparing Endoscopic Retrograde Appendicitis Therapy (ERAT) vs Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis Unknown status NCT02789865 Phase 2 Ertapenem, Levofloxacin and Metronidazole
46 Evaluation of the Effect of Intraperitoneal Nebulized Ropivacaine on Morphine Consumption After Laparoscopic Appendectomy in Children. A Prospective, Randomized Double Blind Clinical Trial Unknown status NCT02624089 Phase 1, Phase 2 Ropivacaine;Normal saline
47 Intraperitoneal Administration of Fosfomycin, Metronidazole and Molgramostim Versus Intravenous Conventional Antibiotics for Perforated Appendicitis - a Pivotal Quasi-randomized Controlled Trial Completed NCT03435900 Phase 2 Combination of fosfomycin, metronidazole and rhGM-CSF (administered together intraperitoneally) and three days of antibiotics p.o.;Standard antibiotics intravenously
48 A Randomized Pilot Trial of Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis Completed NCT02664220 Phase 2 Povidone-iodine irrigation
49 Preoperative Methylprednisolone to Patients Suspected of Appendicitis Undergoing Laparoscopy Completed NCT02711449 Phase 2 Methylprednisolone;0.9% Saline
50 Randomized Study of Conservative Versus Surgical Treatment of Appendicitis; Analyses of Result and Economics Completed NCT00469430 Phase 2 cefotaxim and metronidazol

Search NIH Clinical Center for Appendicitis

Cochrane evidence based reviews: appendicitis

Genetic Tests for Appendicitis

Anatomical Context for Appendicitis

Organs/tissues related to Appendicitis:

MalaCards : Appendix, Kidney, Colon, Ovary, Liver, Small Intestine, Skin

Publications for Appendicitis

Articles related to Appendicitis:

(show top 50) (show all 21344)
# Title Authors PMID Year
1
Paediatric appendicitis: international study of management in the COVID-19 pandemic. 62 41
36240511 2022
2
A comparative study of the RIPASA and Alvarado scores in geriatric patients diagnosed with acute appendicitis. 62 41
36228263 2022
3
Appendiceal microbiome in uncomplicated and complicated acute appendicitis: A prospective cohort study. 62 41
36240181 2022
4
Application with repeated serum biomarkers in pediatric appendicitis in clinical surgery. 53 62
20128109 2010
5
Is C-reactive protein a reliable test for suspected appendicitis in extremely obese children? 53 62
19855981 2010
6
C-Reactive protein is an independent surgical indication marker for appendicitis: a retrospective study. 53 62
19878592 2009
7
[Appendicitis in the elderly. CRP value as decision support for diagnostic laparoscopy]. 53 62
19562239 2009
8
Total leucocyte count, C-reactive protein and neutrophil count: diagnostic aid in acute appendicitis. 53 62
19568576 2009
9
White cell count and C-reactive protein measurement in patients with possible appendicitis. 53 62
19102827 2009
10
C-reactive protein estimation does not improve accuracy in the diagnosis of acute appendicitis in pediatric patients. 53 62
19070557 2009
11
A prospective bicenter study investigating the diagnostic value of procalcitonin in patients with acute appendicitis. 53 62
19672084 2009
12
Role of serum C-reactive protein and leukocyte count in the diagnosis of acute appendicitis in Nepalese population. 53 62
18700623 2008
13
[On the relationship between body dimensions and appendix length]. 53 62
18435206 2008
14
Predictive value of white blood cell count and C-reactive protein in children with appendicitis. 53 62
17618882 2007
15
Inflammatory markers for acute appendicitis in children: are they helpful? 53 62
17502181 2007
16
Ultrasound, computed tomography, and laboratory findings in the diagnosis of appendicitis. 53 62
17453494 2007
17
Interleukin-6 and lipopolysaccharide-binding protein in acute appendicitis in children. 53 62
17365999 2007
18
Diagnostic value of blood inflammatory markers for detection of acute appendicitis in children. 53 62
17132173 2006
19
The role of serum inflammatory markers in acute appendicitis and their success in preventing negative laparotomy. 53 62
17101603 2006
20
Use of changes over time in serum inflammatory parameters in patients with equivocal appendicitis. 53 62
16782436 2006
21
Plasma total anti-oxidant capacity correlates inversely with the extent of acute appendicitis: a case control study. 53 62
16759345 2006
22
Receiver-operating characteristic analysis of leukocyte counts and serum C-reactive protein levels in children with advanced appendicitis. 53 62
16715420 2006
23
Laboratory tests in patients with acute appendicitis. 53 62
16483301 2006
24
[A contemporary situation in the antimicrobial treatment of the secondary peritonitis]. 53 62
16250620 2005
25
Predictive value of C-reactive protein at different cutoff levels in acute appendicitis. 53 62
16032609 2005
26
Procalcitonin as a predictor of severe appendicitis in children. 53 62
15995845 2005
27
Role of leukocyte count, neutrophil percentage, and C-reactive protein in the diagnosis of acute appendicitis in the elderly. 53 62
15943411 2005
28
[Is procalcitonin able to help in pediatric appendicitis diagnosis?]. 53 62
15784220 2005
29
Simple way to improve accuracy in diagnosis of quadrant inflammatory disease: how to avoid adverse laparotomy by using plain CT. 53 62
15783013 2005
30
Serum amyloid A protein levels as a possible aid in the diagnosis of acute appendicitis in children. 53 62
15653442 2005
31
The diagnostic value of C-reactive protein, white blood cell count and neutrophil percentage in childhood appendicitis. 53 62
15448768 2004
32
The role of white cell count and C-reactive protein in the diagnosis of acute appendicitis. 53 62
15631364 2004
33
Accuracy in diagnosis of acute appendicitis by comparing serum C-reactive protein measurements, Alvarado score and clinical impression of surgeons. 53 62
15117047 2004
34
Appendicitis: evaluation of sensitivity, specificity, and predictive values of US, Doppler US, and laboratory findings. 53 62
14688403 2004
35
CRP in acute appendicitis--is it a necessary investigation? 53 62
17462226 2004
36
Plasma D-lactate levels in diagnosis of appendicitis. 53 62
12893500 2003
37
Diagnostic implications of C-reactive protein. 53 62
12578424 2003
38
[Leukocyte count, C reactive protein, alpha-1 acid glycoprotein and erythrocyte sedimentation rate in acute appendicitis]. 53 62
14534661 2003
39
[The value of C-reactive protein and leucocyte count in preventing negative appendectomies]. 53 62
11705213 2001
40
Do normal leucocyte count and C-reactive protein value exclude acute appendicitis in children? 53 62
11440098 2001
41
Repeated clinical and laboratory examinations in patients with an equivocal diagnosis of appendicitis. 53 62
10706923 2000
42
Would measurement of C-reactive protein reduce the rate of negative exploration for acute appendicitis? 53 62
10815376 2000
43
Diagnostic value of interleukin-6 and C-reactive protein in acute appendicitis. 53 62
10967943 2000
44
The accuracy of C-reactive protein in the diagnosis of acute appendicitis compared with that of clinical diagnosis. 53 62
10934841 2000
45
A fertile-aged woman with right lower abdominal pain but unelevated leukocyte count and C-reactive protein. Acute appendicitis is very unlikely. 53 62
10552288 1999
46
Neuroimmune appendicitis. 53 62
10465170 1999
47
Diagnostic accuracy of inflammatory markers in patients operated on for suspected acute appendicitis: a receiver operating characteristic curve analysis. 53 62
10452263 1999
48
Leucocyte count and C-reactive protein in the diagnosis of acute appendicitis. 53 62
10215824 1999
49
Is there a role for leukocyte and CRP measurements in the diagnosis of acute appendicitis in the elderly? 53 62
10340286 1999
50
[Diagnostic value of reactive C protein in suspected acute appendicitis in children]. 53 62
9656532 1998

Variations for Appendicitis

ClinVar genetic disease variations for Appendicitis:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 RET NM_020975.6(RET):c.2988G>A (p.Pro996_Val997=) SNV Uncertain Significance
215914 rs145798106 GRCh37: 10:43620379-43620379
GRCh38: 10:43124931-43124931
2 RET NM_020975.6(RET):c.3148C>T (p.Arg1050Ter) SNV Uncertain Significance
995823 rs767479170 GRCh37: 10:43622131-43622131
GRCh38: 10:43126683-43126683
3 RET NM_020975.6(RET):c.487C>T (p.Arg163Trp) SNV Uncertain Significance
992568 rs371153966 GRCh37: 10:43597939-43597939
GRCh38: 10:43102491-43102491
4 RET NM_020975.6(RET):c.1426C>A (p.Pro476Thr) SNV Uncertain Significance
995822 GRCh37: 10:43606817-43606817
GRCh38: 10:43111369-43111369
5 RET NM_020975.6(RET):c.1946C>T (p.Ser649Leu) SNV Uncertain Significance
24928 rs148935214 GRCh37: 10:43609994-43609994
GRCh38: 10:43114546-43114546
6 RET NM_020975.6(RET):c.2330A>G (p.Asn777Ser) SNV Uncertain Significance
24937 rs377767415 GRCh37: 10:43613866-43613866
GRCh38: 10:43118418-43118418

Expression for Appendicitis

Search GEO for disease gene expression data for Appendicitis.

Pathways for Appendicitis

Pathways related to Appendicitis according to GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 CCL2 CRP CSF3 CXCL8 IFNG IL10
2
Show member pathways
13.88 TNF IL6 IL2 IL1B IL17A IL10
3
Show member pathways
13.76 CCL2 CSF3 CXCL8 IFNG IL10 IL17A
4
Show member pathways
13.63 TNF IL6 IL2 IL1B IL17A IL10
5
Show member pathways
13.55 TNF TLR4 IL6 IL2 IL1B IL17A
6
Show member pathways
13.43 TNF IL6 IL2 IL1B IL17A IL10
7
Show member pathways
13.42 TNF MMP9 LCN2 LBP IL6 IL2
8
Show member pathways
13.02 TNF TLR4 MMP9 LBP IL6 IL2
9
Show member pathways
12.81 TNF IL2 IL1B IFNG CCL2
10 12.81 MMP9 IL6 IL1B IL10 CSF3 CCL2
11
Show member pathways
12.8 CXCL8 IFNG IL10 IL17A IL1B IL2
12
Show member pathways
12.77 TNF TLR4 IL6 IL2 IL1B
13 12.74 TNF MPO IL2 IL1B IL17A IL10
14
Show member pathways
12.73 TNF MPO IL6 IL2 IL1B IL17A
15
Show member pathways
12.63 CXCL8 IL1B IL6 TLR4 TNF
16
Show member pathways
12.6 CXCL8 IFNG IL1B IL6 LBP TLR4
17
Show member pathways
12.51 TNF TLR4 LBP IL6 IL1B IFNG
18
Show member pathways
12.47 CCL2 CSF3 CXCL8 IL17A IL6 MMP9
19 12.34 TNF TLR4 MMP9 IL6 IFNG
20 12.32 CXCL8 IL10 IL1B IL6 TNF
21
Show member pathways
12.3 TNF IL2 IL17A IL10 IFNG
22 12.26 TNF IL6 IL1B IL10 IFNG
23 12.18 TNF MPO IL6 IL2 IL10 IFNG
24
Show member pathways
12.08 TLR4 LBP IL6 IL17A CXCL8 CSF3
25
Show member pathways
12.06 TNF TLR4 IL6 IL2 IL1B IL17A
26 12.05 IL6 IL1B IFNG CXCL8
27
Show member pathways
12.05 TLR4 IL6 IL1B IL17A IFNG
28 12.05 CXCL8 IFNG IL10 IL17A IL1B IL2
29 12.01 IL6 IL10 CXCL8 CCL2
30 11.99 TNF IL2 IL1B IL17A IL10 IFNG
31
Show member pathways
11.97 LBP IL6 CXCL8 CRP CCL2
32 11.96 TLR4 MMP9 IL6 IL2 IL10 IFNG
33 11.94 TNF IL6 IL2 IL1B IL10 IFNG
34 11.92 IL6 IL2 IL1B IL17A IFNG
35 11.91 IL6 IL2 IFNG CXCL8
36 11.91 TNF TLR4 IL6 IL2 IL10 IFNG
37 11.88 CCL2 CXCL8 IFNG IL10 IL2 IL6
38 11.88 CCL2 CXCL8 IL1B IL6 MMP9 S100A9
39 11.86 TNF TLR4 IL6 IL1B IL10
40
Show member pathways
11.85 TNF IL2 IFNG CXCL8
41 11.85 CXCL8 IL10 IL6 LCN2 TLR4 TNF
42
Show member pathways
11.84 TNF IL1B IFNG
43
Show member pathways
11.82 TNF TLR4 IL6 IL2 IL10 IFNG
44
Show member pathways
11.82 TNF MMP9 IL6 IL2 IL1B IFNG
45 11.74 TNF TLR4 IL1B IFNG CCL2
46 11.74 TNF TLR4 IL6 IFNG CXCL8 CCL2
47 11.72 TNF IL10 CXCL8 CCL2
48 11.72 CCL2 CSF3 CXCL8 IL1B IL6 MMP9
49 11.69 IL6 IFNG CXCL8
50 11.69 TNF TLR4 LBP IL6 CCL2

GO Terms for Appendicitis

Cellular components related to Appendicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.23 ALB CCL2 CRP CSF3 CXCL8 IFNG
2 extracellular space GO:0005615 9.9 ALB CCL2 CRP CSF3 CXCL8 IFNG

Biological processes related to Appendicitis according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 10.55 TLR4 S100A9 PTX3 LCN2 LBP IL17A
2 apoptotic process GO:0006915 10.53 TNF S100A9 MMP9 LCN2 IL1B IL17A
3 positive regulation of gene expression GO:0010628 10.51 TNF TLR4 IL6 IL1B IFNG CXCL8
4 negative regulation of apoptotic process GO:0043066 10.49 ALB IL10 IL2 IL6 MMP9 MPO
5 positive regulation of DNA-binding transcription factor activity GO:0051091 10.31 TNF IL6 IL1B IL10 CSF3
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.3 TNF TLR4 S100A9 IL6 IL1B
7 defense response to Gram-negative bacterium GO:0050829 10.29 TLR4 LBP IL6 IL17A
8 defense response to bacterium GO:0042742 10.29 TNF TLR4 S100A9 MPO LCN2 LBP
9 positive regulation of type II interferon production GO:0032729 10.28 TNF TLR4 IL2 IL1B
10 positive regulation of tumor necrosis factor production GO:0032760 10.28 TLR4 LBP IL6 IL17A IFNG
11 defense response to Gram-positive bacterium GO:0050830 10.27 TNF LBP IL6 IL1B IL17A CRP
12 neutrophil chemotaxis GO:0030593 10.26 CCL2 CXCL8 IL1B LBP S100A9
13 inflammatory response GO:0006954 10.26 CCL2 CRP CXCL8 IL17A IL1B IL6
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 10.25 TNF IL6 IL2 IFNG
15 humoral immune response GO:0006959 10.24 CCL2 IFNG IL6 TNF
16 positive regulation of interleukin-8 production GO:0032757 10.24 TNF TLR4 LBP IL6 IL1B
17 positive regulation of inflammatory response GO:0050729 10.23 TNF TLR4 S100A9 IL2 IL1B IFNG
18 positive regulation of phagocytosis GO:0050766 10.22 IFNG IL1B PTX3 TNF
19 positive regulation of interleukin-1 beta production GO:0032731 10.22 IFNG IL17A IL6 TLR4 TNF
20 positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 10.21 TNF MMP9 IL10
21 positive regulation of interleukin-12 production GO:0032735 10.21 TLR4 IL17A IFNG
22 positive regulation of cytokine production GO:0001819 10.21 TNF IL1B IL10 IFNG
23 regulation of insulin secretion GO:0050796 10.21 TNF IL6 IL1B IFNG
24 response to bacterium GO:0009617 10.2 TNF TLR4 LRG1 CCL2
25 immune system process GO:0002376 10.2 IL17A IL2 LBP LCN2 S100A9 TLR4
26 acute-phase response GO:0006953 10.19 LBP IL6 CRP
27 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.19 TNF IL6 IL10
28 defense response to fungus GO:0050832 10.19 IL17A MPO S100A9
29 liver regeneration GO:0097421 10.18 TNF IL6 IL10
30 positive regulation of immunoglobulin production GO:0002639 10.17 IL6 IL2 IL10
31 negative regulation of neurogenesis GO:0050768 10.17 TNF IL6 IL1B
32 positive regulation of interleukin-6 production GO:0032755 10.17 TNF TLR4 LBP IL6 IL1B IL17A
33 positive regulation of osteoclast differentiation GO:0045672 10.16 IFNG IL17A TNF
34 positive regulation of macrophage activation GO:0043032 10.15 TLR4 LBP IL10
35 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.15 TNF TLR4 IL6 IL17A
36 response to lipopolysaccharide GO:0032496 10.15 IL10 IL1B LBP MPO S100A9 TLR4
37 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 10.14 CCL2 IFNG TLR4
38 positive regulation of glial cell proliferation GO:0060252 10.13 IL1B IL6 TNF
39 positive regulation of nitric oxide biosynthetic process GO:0045429 10.13 IFNG IL1B PTX3 TLR4 TNF
40 positive regulation of membrane protein ectodomain proteolysis GO:0051044 10.12 TNF IL1B IFNG
41 positive regulation of heterotypic cell-cell adhesion GO:0034116 10.11 TNF IL1B IL10
42 astrocyte activation GO:0048143 10.1 TNF IL1B IFNG
43 positive regulation of MHC class II biosynthetic process GO:0045348 10.1 TLR4 IL10 IFNG
44 lipopolysaccharide-mediated signaling pathway GO:0031663 10.1 TNF TLR4 LBP IL1B CCL2
45 positive regulation of neuroinflammatory response GO:0150078 10.08 TNF IL6 IL1B
46 negative regulation of lipid storage GO:0010888 10.07 CRP IL6 TNF
47 opsonization GO:0008228 10.05 PTX3 LBP CRP
48 vascular endothelial growth factor production GO:0010573 10.04 TNF IL6 IL1B
49 negative regulation of cytokine production involved in immune response GO:0002719 10.03 TNF IL10
50 intestinal epithelial structure maintenance GO:0060729 10.02 TLR4 IL17A

Molecular functions related to Appendicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.81 TNF TLR4 LBP IL6 CSF3 CCL2
2 cytokine activity GO:0005125 9.58 TNF IL6 IL2 IL1B IL17A IL10
3 enterobactin binding GO:1903981 9.26 LCN2 ALB

Sources for Appendicitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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