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MCID: APP008
MIFTS: 60

Appendicitis

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Appendicitis

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MalaCards integrated aliases for Appendicitis:

Name: Appendicitis 12 74 54 42 43 15 17 71
Acute Appendicitis 12 54 15 32
Acute Appendicitis with Generalized Peritonitis 12 32
Acute Appendicitis with Peritoneal Abscess 12
Acute Appendicitis Nos 71

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:8337
ICD9CM 34 540-543.99 541
MeSH 43 D001064
NCIt 49 C35145
SNOMED-CT 67 74400008
UMLS 71 C0003615 C0085693
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Summaries for Appendicitis

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MedlinePlus : 42 The appendix is a small, tube-like organ attached to the first part of the large intestine. It is located in the lower right part of the abdomen. It has no known function. A blockage inside of the appendix causes appendicitis. The blockage leads to increased pressure, problems with blood flow, and inflammation. If the blockage is not treated, the appendix can burst and spread infection into the abdomen. This causes a condition called peritonitis. The main symptom is pain in the abdomen, often on the right side. It is usually sudden and gets worse over time. Other symptoms may include Swelling in the abdomen Loss of appetite Nausea and vomiting Constipation or diarrhea Inability to pass gas Low fever Not everyone with appendicitis has all these symptoms. Appendicitis is a medical emergency. Treatment almost always involves removing the appendix. Anyone can get appendicitis, but it is more common among people 10 to 30 years old. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Appendicitis, also known as acute appendicitis, is related to intussusception and intestinal obstruction, and has symptoms including vomiting, fever and pain. An important gene associated with Appendicitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Aztreonam and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include appendix, colon and liver, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has symptom pain, in the upper abdomen initially and later in the lower abdomen, has symptom nausea, has symptom vomiting and has symptom fever.

Wikipedia : 74 Appendicitis is inflammation of the appendix. Symptoms commonly include right lower abdominal pain,... more...

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Related Diseases for Appendicitis

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Diseases related to Appendicitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1168)
# Related Disease Score Top Affiliating Genes
1 intussusception 31.4 IL6 CRP ALB
2 intestinal obstruction 31.4 IL6 CRP ALB
3 fasciitis 31.2 TNF IL6 CXCL8
4 diverticulitis 31.2 TNF S100A9 MMP9 IL6 CRP ALB
5 cholecystitis 31.1 TLR4 S100A9 ALB
6 purpura 31.0 TNF IL6 IL10 CRP
7 endometriosis 30.9 IL6 IL1B CXCL8 CCL2
8 ascaris lumbricoides infection 30.9 IL6 IL1B CXCL8
9 ileus 30.9 TNF IL6 IL1B IL17A IL10 CRP
10 intestinal perforation 30.9 IL6 CRP ALB
11 crohn's colitis 30.9 TNF IL1B CXCL8
12 necrotizing fasciitis 30.8 IL6 CXCL8 CRP ALB
13 neutropenia 30.8 MPO IL6 CSF3 CRP
14 measles 30.8 TNF TLR4 IL6 IL1B
15 cellulitis 30.7 TNF IL6 IL10 CRP
16 schistosomiasis 30.7 TNF IL17A IL10 CCL2 ALB
17 intestinal tuberculosis 30.7 TNF CRP ALB
18 clostridium difficile colitis 30.6 IL1B CRP ALB
19 gastrointestinal tuberculosis 30.6 TNF CRP ALB
20 lymphadenitis 30.6 TNF TLR4 IL1B IL10 CXCL8 CRP
21 vaginal discharge 30.6 IL6 CXCL8 CRP
22 peptic ulcer disease 30.5 TNF IL1B IL10 CXCL8 ALB
23 orchitis 30.5 TNF IL6 IL10 CRP
24 pyuria 30.5 IL6 CXCL8 CRP ALB
25 sarcoidosis 1 30.5 TNF S100A9 IL1B CRP CCL2
26 polyarteritis nodosa 30.5 MPO IL6 CRP
27 gastric ulcer 30.5 TNF MMP9 IL6 IL1B CXCL8
28 peptic ulcer perforation 30.4 CRP ALB
29 granulocytopenia 30.4 TNF MPO CSF3
30 hydronephrosis 30.4 MMP9 IL6 CXCL8 CRP CCL2 ALB
31 syphilis 30.4 IL17A CRP ALB
32 chickenpox 30.4 TNF IL6 IL10 CRP ALB
33 acquired immunodeficiency syndrome 30.4 TNF IL6 IL1B IL10 CRP ALB
34 leptin deficiency or dysfunction 30.4 TNF IL6 CRP ALB
35 pelvic inflammatory disease 30.3 TLR4 MPO MMP9 CRP CCL2
36 end stage renal failure 30.3 TNF IL6 CRP ALB
37 pericardial effusion 30.3 IL6 CRP ALB
38 placenta disease 30.3 TNF IL6 IL1B CXCL8 CRP
39 rheumatic fever 30.3 TNF IL6 IL10 ALB
40 taeniasis 30.3 TLR4 IL10 ALB
41 abdominal tuberculosis 30.3 TNF CRP ALB
42 mycobacterium tuberculosis 1 30.3 TNF TLR4 IL17A IL10 CRP
43 aortic aneurysm, familial abdominal, 1 30.3 MMP9 MMP8 IL6 CRP CCL2
44 scarlet fever 30.3 TNF CRP ALB
45 parotitis 30.3 MMP9 CRP ALB
46 spinal cord injury 30.2 TNF MMP9 IL6 CXCL8
47 ileitis 30.2 TNF TLR4 MPO IL6 IL17A IL10
48 duodenal ulcer 30.2 TNF TLR4 IL6 IL1B IL10 CXCL8
49 mumps 30.2 TNF IL6 IL10 CXCL8
50 post-transplant lymphoproliferative disease 30.2 TNF IL6 IL10

Graphical network of the top 20 diseases related to Appendicitis:



Diseases related to Appendicitis
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Symptoms & Phenotypes for Appendicitis

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Symptoms:

12
  • • vomiting
  • • fever
  • • pain
  • • nausea

UMLS symptoms related to Appendicitis:


nausea and vomiting, constipation, abdominal pain, diarrhea, icterus, dyspepsia, heartburn, gastrointestinal gas

MGI Mouse Phenotypes related to Appendicitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 CSF3 IL10 IL17A IL1B IL6 LBP
2 homeostasis/metabolism MP:0005376 9.97 ALB CRP IL10 IL17A IL1B IL6
3 immune system MP:0005387 9.83 ALB CCL2 CRP CSF3 IL10 IL17A
4 neoplasm MP:0002006 9.28 ALB IL10 IL1B IL6 LRG1 MMP8
Sources

Drugs & Therapeutics for Appendicitis

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Drugs for Appendicitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 205)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aztreonam Approved Phase 4 78110-38-0 5362041 5742832
2
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
3
Morphine Approved, Investigational Phase 4 57-27-2 5288826
4
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
5
Tigecycline Approved Phase 4 220620-09-7 5282044
6
Nabumetone Approved Phase 4 42924-53-8 4409
7
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
9
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
10
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
11
Nalbuphine Approved Phase 4 20594-83-6 5360630 5311304
12
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
13
Iodine Approved, Investigational Phase 4 7553-56-2 807
14
Povidone Approved Phase 4 9003-39-8
15
Povidone-iodine Approved Phase 4 25655-41-8
16
Piperacillin Approved Phase 4 66258-76-2 43672
17
Tazobactam Approved Phase 4 89786-04-9 123630
18
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
19
Ofloxacin Approved Phase 4 82419-36-1 4583
20 Renal Agents Phase 4
21 Anti-Infective Agents, Urinary Phase 4
22 Adrenergic alpha-2 Receptor Agonists Phase 4
23 Hypnotics and Sedatives Phase 4
24 Analgesics, Opioid Phase 4
25 Analgesics, Non-Narcotic Phase 4
26 Cyclooxygenase Inhibitors Phase 4
27 Anti-Inflammatory Agents, Non-Steroidal Phase 4
28 Antirheumatic Agents Phase 4
29 Cyclooxygenase 2 Inhibitors Phase 4
30 Analgesics Phase 4
31 Gentamicins Phase 4
32 Anti-Arrhythmia Agents Phase 4
33 Sodium Channel Blockers Phase 4
34 Diuretics, Potassium Sparing Phase 4
35 Antitubercular Agents Phase 4
36 cadexomer iodine Phase 4
37 Hemostatics Phase 4
38 Plasma Substitutes Phase 4
39 Nutrients Phase 4
40 Anti-Infective Agents, Local Phase 4
41 Trace Elements Phase 4
42 Micronutrients Phase 4
43 Blood Substitutes Phase 4
44 Piperacillin, Tazobactam Drug Combination Phase 4
45 Cytochrome P-450 Enzyme Inhibitors Phase 4
46 Topoisomerase Inhibitors Phase 4
47 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
48 Anesthetics Phase 4
49 Anesthetics, General Phase 4
50
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943

Interventional clinical trials:

(show top 50) (show all 273)
# Name Status NCT ID Phase Drugs
1 Antibiotics vs.Surgery in Acute Appendicitis;an Intention to Treat Prospective Randomised Study. The ASAA-study Unknown status NCT01421901 Phase 4 Ertapenem
2 An Open-Lable Multicenter Prospective Non-Randomized Trial to Assess the Efficacy and Safety of Morinidazole With Surgery in Patients With Suppurative or Gangrenous Appendicitis Unknown status NCT03380793 Phase 4 morinidazole
3 Intraperitoneal Dexmedetomidine as an Adjuvant to Bupivacaine for Management of Pain in Children Undergoing Laparoscopic Appendicectomy: A Prospective Randomized Trial Unknown status NCT03067740 Phase 4 Bupivacaine;Dexmedetomidine
4 An Open-Lable Multicenter Prospective Non-Randomized Trial to Assess the Efficacy and Safety of Morinidazole With Levofloxacin and Sequential of Levofloxacin in Women With Pelvic Inflammatory Disease Unknown status NCT03391440 Phase 4 morinidazole
5 Laparoscopic Versus Open Appendectomy: A Retrospective Cohort Study Assessing Outcomes and Cost-effectiveness Completed NCT02867072 Phase 4
6 Effect of Pain Control on the Diagnosis of Acute Appendicitis on the Diagnostic Accuracy of General Surgeon Completed NCT00783016 Phase 4 Morphine
7 Double Blind Randomized Study of Morphine Analgesia in Patients With Acute Appendicitis Completed NCT00477061 Phase 4 Morphine
8 Non Operative Treatment for Acute Appendicitis: Study on Efficacy and Safety of Antibiotic Treatment (Amoxicillin and Clavulanic Acid) in Patients With Right Sided Lower Abdominal Pain Completed NCT01096927 Phase 4 Amoxicillin and Clavulanic Acid
9 Comparison Between Intradermic vs Habitual Skin Closure Technique in Open Appendicectomy. Completed NCT02625987 Phase 4
10 A Randomized Comparison of Ultrasound Guided Bilateral Rectus Sheath Block and Local Anesthetic Infiltration for Postoperative Pain Control in Children With Acute Appendicitis Completed NCT02352519 Phase 4
11 Wound Healing and Cosmetic Result After Emergency Appendicectomy in Adult Patients: a Prospective, Randomised Trial Comparing Two Methods of Wound Closure Completed NCT00913445 Phase 4
12 Pain Post Abdominal Laparoscopy Prevention With Arcoxia Completed NCT00565682 Phase 4 etoricoxib 120 mg
13 A Multicenter, Open-Label, Randomized Comparative Study of Tigecycline vs Ceftriaxone Sodium Plus Metronidazole for the Treatment of Hospitalized Subjects With Complicated Intra-abdominal Infection Completed NCT00195351 Phase 4 tigecycline;ceftriaxone sodium + metronidazole
14 Safety and Efficacy of Single Daily Dose of Ceftriaxone and Metronidazole for Treatment of Complicated Appendicitis in Children Completed NCT01678365 Phase 4 ceftriaxone, metronidazole/ampicillin, gentamicin, and metronidazole
15 A Multicenter, Open-Label, Randomized Comparative Study of Tigecycline vs Ceftriaxone Sodium Plus Metronidazole for the Treatment of Hospitalized Subjects With Complicated Intra-abdominal Infection Completed NCT00230971 Phase 4 tigecycline;ceftriaxone plus metronidazole
16 Choose Between Two Different Concentration of Ropivacaine on TAP Block for Children Submitted of Open Appendectomy Completed NCT03005808 Phase 4 Ropivacaine
17 Optimized Treatment for Uncomplicated Acute Appendicitis; Active Observation With or Without Antibiotic Treatment Recruiting NCT03985514 Phase 4 Antibiotic treatment (Piperacillin/Tazobactam, 4 gram x 3), followed by 8-10 days of out-hospital oral antibiotic treatment (Ciprofloxacin 500 mgx2,Flagyl 400 mgx3).
18 The Interest of Wound Infiltration With Local Anesthetic Agent for Laparoscopic Appendectomy in Adult: a Double Blind, Prospective, Randomized Control Trial Recruiting NCT03481517 Phase 4 Bupivacaine
19 Efficacy of Intravenous Lidocaine Infusion on Pain Relief in Children Undergoing Laparoscopic Appendectomy: Randomized Controlled Trial. Recruiting NCT03886896 Phase 4 Lidocaine
20 Randomized Control Trial: Two Different Antibiotics Versus One Antibiotic for Pediatric Perforated Appendicitis Recruiting NCT03289351 Phase 4 piperacillin-tazobactam
21 Initial Non-operative Treatment Strategy Versus Appendectomy Treatment Strategy for Simple Appendicitis in Children Aged 7-17 Years Old - Antibiotics Versus Primary Appendectomy in Children With Simple Appendicitis: APAC Study Recruiting NCT02848820 Phase 4 Augmentin + Gentamicin
22 COMPARISON OF TRANSVERSUS ABDOMINIS PLANE BLOCK, LOCAL ANESTHETIC INJECTION TO THE PORT SITES AND INTRAPERITONEAL LOCAL ANESTHESIA APPLICATIONS IN POSTOPERATIVE PAIN MANAGEMENT IN PATIENTS WITH LAPAROSCOPIC APPENDECTOMY Active, not recruiting NCT03790020 Phase 4 Bupivacaine
23 A Prospective, Randomized Trial of Antibiotic Duration in Post-appendectomy Abscess Not yet recruiting NCT03795194 Phase 4 ampicillin/clavulanate
24 Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis Not yet recruiting NCT04200729 Phase 4 Irrigation with PVI
25 A Multi-center, Open-label, Randomized Study to Compare the Safety and Efficacy of Once Daily Levofloxacin Along With Once Daily Metronidazole Versus Piperacillin/Tazobactam in the Treatment of Complicated Appendicitis Terminated NCT00236912 Phase 4 levofloxacin; metronidazole
26 First Laparoscopy or Active Observation in Acute Non-specific Abdominal Pain: The FLO Trial Terminated NCT01675466 Phase 4
27 Metronidazole Every 24 Hours as Part of Triple Antibiotic Therapy for Ruptured Appendicitis in Children Managed Operatively (METRO): a Noninferiority Randomized Controlled Trial Withdrawn NCT02561117 Phase 4 Metronidazole
28 Randomized Controlled Trial Comparing Single Incision Laparoscopic Appendectomy Versus Standard Three Port Appendectomy in a Selected Cohort of Patients Unknown status NCT01720082 Phase 3
29 The Prospective Randomized Comparison of the Onset Time of Rocuronium in Patients Undergoing Emergency and Elective Surgery Unknown status NCT02634255 Phase 3 Rocuronium elective surgery;Rocuronium emergency surgery;Propofol;Fentanyl
30 PROSPECTIVE EVALUATION OF OUTPATIENT APPENDECTOMY FOR NON COMPLICATED ACUTE APPENDICITIS: Intention-to-treat Study Completed NCT01839435 Phase 3
31 Negative Appendectomy Rate Following Low-dose CT vs. Standard-dose CT Completed NCT00913380 Phase 3
32 Phase 3 Study of Antibiotic Prophylaxis Use Prior Emergent Surgery, Because of Acute Appendicitis Completed NCT01524081 Phase 3 Metronidazole, Cefuroxime;Amoxicillin (+ clavulanic acid) and Fluconazole;Placebo;Placebo
33 Prospective Randomised Study Comparing Single Incision Transumbilical Versus Conventional Laparoscopic Appendectomy Completed NCT01515293 Phase 3
34 Early Versus Interval Appendectomy for Ruptured Appendicitis in Children. Ruptured Appendicitis Pilot Trial (RAPTOR) Completed NCT00435032 Phase 3
35 Comparison of Surgical Site Infection Between Delayed Primary Closure Versus Primary Closure in Complicated Appendicitis: A Multicenter Randomized Controlled Trial Completed NCT01659983 Phase 3
36 Elective Laparoscopic Appendectomy for Chronic Right Lower Abdominal Pain; Outcome of a Prospective Randomized Double-Blind Controlled Surgical Trial Completed NCT00413855 Phase 3
37 A Multicenter, Double-Blind, Randomized, Phase 3 Study of Doripenem Versus Comparator Antibiotic in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00210938 Phase 3 Doripenem
38 A Multicenter, Double-Blind, Randomized, Phase 3 Study of Doripenem Versus Comparator Antibiotic in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00229060 Phase 3 doripenem
39 A Phase 3, Randomized, Double-Blind, Double-Dummy, Multicenter, Prospective Study to Assess the Efficacy and Safety of Eravacycline Compared With Meropenem in Complicated Intra-abdominal Infections Completed NCT02784704 Phase 3 Eravacycline;Meropenem;Placebo
40 A Double-blinded Randomised Controlled Trial of Laparoendoscopic Single-site Access (LESS) Versus Conventional Three-port Appendicectomy. Completed NCT01203566 Phase 3
41 Hyoscine Hydrobromide (Buscopan) Versus Acetaminophen for Acute Abdominal Pain in Children: A Randomized Controlled Trial Completed NCT02582307 Phase 3 Acetaminophen, Analgesics, Non-Narcotic;Hyoscine butylbromide, Analgesics, Non-Narcotic
42 Non Operative Treatment With Antibiotics Vs Surgery for Acute Non Perforated Appendicitis in Children: A Randomized Controlled Trial. Recruiting NCT04030741 Phase 2, Phase 3 Meronem and flagyl
43 The Value of Post-operative Antibiotic Therapy After Laparoscopic Appendectomy for Complicated Acute Appendicitis (Other Than for Generalized Peritonitis): a Prospective, Randomized, Placebo-controlled Phase III Study Not yet recruiting NCT03688295 Phase 3 Antibiotics
44 Operative Versus Non-Operative Management for Appendicitis With Abscess or Phlegmon Not yet recruiting NCT04168866 Phase 2, Phase 3
45 A Prospective, Randomized, Double-Blind, Multicenter Study to Establish the Safety and Tolerability of Doripenem Compared With Meropenem in Hospitalized Children With Complicated Intra-Abdominal Infections Terminated NCT01110382 Phase 3 Doripenem;Meropenem placebo;Meropenem;Doripenem placebo;Amoxicillin/clavulanate potassium
46 Multicenter Prospective Randomized Clinical Trial Comparing Endoscopic Retrograde Appendicitis Therapy (ERAT) vs Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis Unknown status NCT02789865 Phase 2 Ertapenem, Levofloxacin and Metronidazole
47 Evaluation of the Effect of Intraperitoneal Nebulized Ropivacaine on Morphine Consumption After Laparoscopic Appendectomy in Children. A Prospective, Randomized Double Blind Clinical Trial Unknown status NCT02624089 Phase 1, Phase 2 Ropivacaine;Normal saline
48 Randomized Study of Conservative Versus Surgical Treatment of Appendicitis; Analyses of Result and Economics Completed NCT00469430 Phase 2 cefotaxim and metronidazol
49 A Randomized Pilot Trial of Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis Completed NCT02664220 Phase 2 Povidone-iodine irrigation
50 The Safety and Pharmacokinetics of Intraperitoneal Administration of Granulocyte-macrophage Colony-stimulating Factor, Fosfomycin, and Metronidazole in Patients Undergoing Appendectomy for Uncomplicated Appendicitis Completed NCT03046758 Phase 2 A combination of fosfomycin, metronidazole and GM-CSF i.p.

Search NIH Clinical Center for Appendicitis

Cochrane evidence based reviews: appendicitis

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Genetic Tests for Appendicitis

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Anatomical Context for Appendicitis

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MalaCards organs/tissues related to Appendicitis:

40
Appendix, Colon, Liver, Kidney, Testes, Bone, Neutrophil
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Publications for Appendicitis

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Articles related to Appendicitis:

(show top 50) (show all 18332)
# Title Authors PMID Year
1
Evaluation of the diagnostic performance of a decision tree model in suspected acute appendicitis with equivocal preoperative computed tomography findings compared with Alvarado, Eskelinen, and adult appendicitis scores: A STARD compliant article. 61 42
31577737 2019
2
Relationship between the time required for transfer and outcomes in patients with appendicitis: Experience at a tertiary military hospital in South Korea. 61 42
31651903 2019
3
Appendectomy and rheumatoid arthritis: A longitudinal follow-up study using a national sample cohort. 61 42
31577706 2019
4
Application with repeated serum biomarkers in pediatric appendicitis in clinical surgery. 54 61
20128109 2010
5
Is C-reactive protein a reliable test for suspected appendicitis in extremely obese children? 54 61
19855981 2010
6
C-Reactive protein is an independent surgical indication marker for appendicitis: a retrospective study. 54 61
19878592 2009
7
[Appendicitis in the elderly. CRP value as decision support for diagnostic laparoscopy]. 54 61
19562239 2009
8
Total leucocyte count, C-reactive protein and neutrophil count: diagnostic aid in acute appendicitis. 54 61
19568576 2009
9
White cell count and C-reactive protein measurement in patients with possible appendicitis. 54 61
19102827 2009
10
C-reactive protein estimation does not improve accuracy in the diagnosis of acute appendicitis in pediatric patients. 54 61
19070557 2009
11
A prospective bicenter study investigating the diagnostic value of procalcitonin in patients with acute appendicitis. 54 61
19672084 2009
12
Role of serum C-reactive protein and leukocyte count in the diagnosis of acute appendicitis in Nepalese population. 54 61
18700623 2008
13
[On the relationship between body dimensions and appendix length]. 54 61
18435206 2008
14
Predictive value of white blood cell count and C-reactive protein in children with appendicitis. 54 61
17618882 2007
15
Inflammatory markers for acute appendicitis in children: are they helpful? 54 61
17502181 2007
16
Ultrasound, computed tomography, and laboratory findings in the diagnosis of appendicitis. 54 61
17453494 2007
17
Interleukin-6 and lipopolysaccharide-binding protein in acute appendicitis in children. 54 61
17365999 2007
18
The role of serum inflammatory markers in acute appendicitis and their success in preventing negative laparotomy. 54 61
17101603 2006
19
Diagnostic value of blood inflammatory markers for detection of acute appendicitis in children. 54 61
17132173 2006
20
Use of changes over time in serum inflammatory parameters in patients with equivocal appendicitis. 54 61
16782436 2006
21
Plasma total anti-oxidant capacity correlates inversely with the extent of acute appendicitis: a case control study. 54 61
16759345 2006
22
Receiver-operating characteristic analysis of leukocyte counts and serum C-reactive protein levels in children with advanced appendicitis. 54 61
16715420 2006
23
Laboratory tests in patients with acute appendicitis. 54 61
16483301 2006
24
[A contemporary situation in the antimicrobial treatment of the secondary peritonitis]. 54 61
16250620 2005
25
Predictive value of C-reactive protein at different cutoff levels in acute appendicitis. 54 61
16032609 2005
26
Procalcitonin as a predictor of severe appendicitis in children. 54 61
15995845 2005
27
Role of leukocyte count, neutrophil percentage, and C-reactive protein in the diagnosis of acute appendicitis in the elderly. 54 61
15943411 2005
28
[Is procalcitonin able to help in pediatric appendicitis diagnosis?]. 54 61
15784220 2005
29
Serum amyloid A protein levels as a possible aid in the diagnosis of acute appendicitis in children. 54 61
15653442 2005
30
Simple way to improve accuracy in diagnosis of quadrant inflammatory disease: how to avoid adverse laparotomy by using plain CT. 54 61
15783013 2005
31
The diagnostic value of C-reactive protein, white blood cell count and neutrophil percentage in childhood appendicitis. 54 61
15448768 2004
32
The role of white cell count and C-reactive protein in the diagnosis of acute appendicitis. 54 61
15631364 2004
33
Accuracy in diagnosis of acute appendicitis by comparing serum C-reactive protein measurements, Alvarado score and clinical impression of surgeons. 54 61
15117047 2004
34
Appendicitis: evaluation of sensitivity, specificity, and predictive values of US, Doppler US, and laboratory findings. 54 61
14688403 2004
35
CRP in acute appendicitis--is it a necessary investigation? 54 61
17462226 2004
36
Plasma D-lactate levels in diagnosis of appendicitis. 54 61
12893500 2003
37
Diagnostic implications of C-reactive protein. 54 61
12578424 2003
38
[Leukocyte count, C reactive protein, alpha-1 acid glycoprotein and erythrocyte sedimentation rate in acute appendicitis]. 54 61
14534661 2003
39
[The value of C-reactive protein and leucocyte count in preventing negative appendectomies]. 54 61
11705213 2001
40
Do normal leucocyte count and C-reactive protein value exclude acute appendicitis in children? 54 61
11440098 2001
41
Repeated clinical and laboratory examinations in patients with an equivocal diagnosis of appendicitis. 54 61
10706923 2000
42
Would measurement of C-reactive protein reduce the rate of negative exploration for acute appendicitis? 54 61
10815376 2000
43
Diagnostic value of interleukin-6 and C-reactive protein in acute appendicitis. 54 61
10967943 2000
44
The accuracy of C-reactive protein in the diagnosis of acute appendicitis compared with that of clinical diagnosis. 54 61
10934841 2000
45
A fertile-aged woman with right lower abdominal pain but unelevated leukocyte count and C-reactive protein. Acute appendicitis is very unlikely. 54 61
10552288 1999
46
Neuroimmune appendicitis. 54 61
10465170 1999
47
Diagnostic accuracy of inflammatory markers in patients operated on for suspected acute appendicitis: a receiver operating characteristic curve analysis. 54 61
10452263 1999
48
Leucocyte count and C-reactive protein in the diagnosis of acute appendicitis. 54 61
10215824 1999
49
Is there a role for leukocyte and CRP measurements in the diagnosis of acute appendicitis in the elderly? 54 61
10340286 1999
50
[Diagnostic value of reactive C protein in suspected acute appendicitis in children]. 54 61
9656532 1998
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Variations for Appendicitis

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Expression for Appendicitis

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Search GEO for disease gene expression data for Appendicitis.
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Pathways for Appendicitis

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Pathways related to Appendicitis according to GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.95 TNF TLR4 S100A9 ORM1 MPO MMP9
2
PEDF Induced Signaling 63
Show member pathways
 13.74 TNF TLR4 IL6 IL1B IL17A IL10
3
Akt Signaling 63
Show member pathways
 13.5 TNF TLR4 IL6 IL1B IL17A IL10
4
Cytokine Signaling in Immune system 65
Show member pathways
 13.47 TNF MMP9 LBP IL6 IL1B IL17A
5
PAK Pathway 63
Show member pathways
 13.38 TNF IL6 IL1B IL17A IL10 CXCL8
6
Toll-like Receptor Signaling Pathway 1 36
Show member pathways
 13.24 TNF TLR4 MMP9 LBP IL6 IL1B
7
Human cytomegalovirus infection 36
Show member pathways
 13 TNF TLR4 IL6 IL1B CXCL8 CCL2
8
Allograft rejection 1 36
Show member pathways
 12.94 TNF IL6 IL1B IL17A IL10 CXCL8
9
Measles 36
Show member pathways
 12.9 TNF TLR4 IL6 IL1B CXCL8 CCL2
10
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 65
Show member pathways
 12.86 TNF TLR4 IL6 IL1B HMGB1 CXCL8
11
T cell receptor signaling pathway 36
Show member pathways
 12.72 TNF TLR4 IL6 IL1B IL17A IL10
12
Immune response IL-23 signaling pathway 22
Show member pathways
 12.72 TNF MPO IL6 IL1B IL17A IL10
13
Th17 cell differentiation 36
Show member pathways
 12.71 TNF TLR4 IL6 IL1B IL17A IL10
14
NF-kappaB Signaling 4
12.68 TNF MPO IL1B IL17A IL10 CCL2
15
Toll Comparative Pathway 63
Show member pathways
 12.46 TNF TLR4 LBP IL6 IL1B CXCL8
16
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.44 TNF IL6 IL10 CXCL8 CCL2
17
Folate Metabolism 1
Show member pathways
 12.43 TNF MPO IL6 IL1B CRP CCL2
18
Shigellosis 36
12.42 TNF TLR4 IL1B CXCL8
19
Pathogenic Escherichia coli infection 36
12.41 TNF TLR4 IL6 IL1B CXCL8
20
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.38 TNF IL6 IL1B IL17A IL10 CXCL8
21
NOD-like receptor signaling pathway 36
12.37 TNF TLR4 IL6 IL1B CXCL8 CCL2
22
Tuberculosis 36
12.36 TNF TLR4 LBP IL6 IL1B IL10
23
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.32 TNF TLR4 IL6 CXCL8
24
Toxoplasmosis 36
Show member pathways
 12.32 TNF TLR4 IL1B IL10
25
Transcriptional misregulation in cancer 36
12.31 MPO MMP9 IL6 CXCL8
26
Bacterial infections in CF airways 22
Show member pathways
 12.31 TNF TLR4 LBP IL6 IL1B CXCL8
27
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.3 TNF IL6 IL1B IL10 CXCL8
28
IL-1 Family Signaling Pathways 64
Show member pathways
 12.28 TNF IL6 IL1B CXCL8
29
Necroptosis 36
Show member pathways
 12.27 TNF TLR4 IL1B HMGB1
30
C-type lectin receptor signaling pathway 36
Show member pathways
 12.27 TNF IL6 IL1B IL10
31
Colorectal Cancer Metastasis 63
12.25 TNF TLR4 MMP9 IL6
32
IL-17 Family Signaling Pathways 64
Show member pathways
 12.24 TNF S100A9 MMP9 IL6 IL1B IL17A
33
Fluid shear stress and atherosclerosis 36
12.17 TNF MMP9 IL1B CCL2
34
Th1 Differentiation Pathway 64
Show member pathways
 12.17 TNF TLR4 IL6 IL1B IL17A IL10
35
Microglia Activation During Neuroinflammation: Overview 64
Show member pathways
 12.15 TNF TLR4 MMP9 IL6 IL1B HMGB1
36
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
12.14 TNF MPO IL6 IL10 CSF3
37
TNF signaling pathway 36
12.12 TNF MMP9 IL6 IL1B CCL2
38
Yersinia infection 36
12.1 TNF TLR4 IL6 IL1B IL10 CXCL8
39
Spinal Cord Injury 1
12.08 TNF TLR4 MMP9 IL6 IL1B CXCL8
40
NF-kappa B signaling pathway 36
12.07 TNF TLR4 LBP IL1B CXCL8
41
AGE-RAGE signaling pathway in diabetic complications 36
12.06 TNF IL6 IL1B CXCL8 CCL2
42
Amoebiasis 36
12.03 TNF TLR4 IL6 IL1B IL10 CXCL8
43
Hematopoietic cell lineage 36
12.01 TNF IL6 IL1B CSF3
44
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.98 TLR4 LBP IL6 IL17A CXCL8 CSF3
45
Rheumatoid arthritis 36
11.95 TNF TLR4 IL6 IL1B IL17A CXCL8
46
Salmonella infection (KEGG) 36
11.94 TLR4 LBP IL6 IL1B CXCL8
47
Innate Lymphoid Cell Differentiation Pathways 64
11.91 TNF IL1B IL17A IL10
48
Dendritic Cells Developmental Lineage Pathway 64
11.87 TNF IL6 IL1B IL10
49
Pertussis 36
11.85 TNF TLR4 IL6 IL1B IL10 CXCL8
50
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.8 TNF MMP9 IL6 IL1B CXCL8
Sources

GO Terms for Appendicitis

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Cellular components related to Appendicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 TNF S100A9 ORM1 MPO MMP9 MMP8
2 extracellular space GO:0005615 9.6 TNF S100A9 ORM1 MPO MMP9 MMP8
3 tertiary granule lumen GO:1904724 9.46 ORM1 MMP9 MMP8 LRG1
4 specific granule lumen GO:0035580 9.43 ORM1 MMP8 LRG1

Biological processes related to Appendicitis according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.25 TNF TLR4 IL6 IL1B IL17A IL10
2 neutrophil degranulation GO:0043312 10.14 S100A9 ORM1 MPO MMP9 MMP8 LRG1
3 positive regulation of gene expression GO:0010628 10.12 TNF TLR4 MMP8 IL6 IL1B CRP
4 immune response GO:0006955 10.06 TNF TLR4 IL6 IL1B IL17A IL10
5 defense response to bacterium GO:0042742 10.03 TNF TLR4 S100A9 MPO LBP IL10
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.02 TNF TLR4 HMGB1 CCL2
7 response to lipopolysaccharide GO:0032496 10.02 TLR4 MPO LBP IL1B IL10
8 chemotaxis GO:0006935 10 S100A9 HMGB1 CXCL8 CCL2
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 10 TNF TLR4 S100A9 IL6 IL1B
10 defense response to Gram-positive bacterium GO:0050830 9.96 TNF LBP IL6 CRP
11 positive regulation of DNA-binding transcription factor activity GO:0051091 9.95 TNF IL6 IL1B IL10 CSF3
12 positive regulation of inflammatory response GO:0050729 9.94 TNF TLR4 S100A9 IL1B
13 neutrophil chemotaxis GO:0030593 9.94 S100A9 IL1B CXCL8 CCL2
14 negative regulation of tumor necrosis factor production GO:0032720 9.91 TLR4 ORM1 LBP IL10
15 cellular response to organic cyclic compound GO:0071407 9.89 TNF IL1B CCL2
16 response to glucocorticoid GO:0051384 9.89 TNF IL6 IL10
17 positive regulation of JNK cascade GO:0046330 9.89 TNF TLR4 MMP8 IL1B HMGB1
18 humoral immune response GO:0006959 9.88 TNF IL6 CCL2
19 positive regulation of tumor necrosis factor production GO:0032760 9.88 TLR4 LBP HMGB1
20 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.88 TNF MMP9 IL10
21 positive regulation of nitric oxide biosynthetic process GO:0045429 9.88 TNF TLR4 MMP8 IL1B
22 positive regulation of interferon-gamma production GO:0032729 9.87 TNF TLR4 IL1B
23 toll-like receptor signaling pathway GO:0002224 9.87 TLR4 S100A9 LBP HMGB1
24 protein kinase B signaling GO:0043491 9.86 TNF IL1B CCL2
25 positive regulation of interleukin-1 beta secretion GO:0050718 9.86 TLR4 ORM1 HMGB1
26 negative regulation of interferon-gamma production GO:0032689 9.85 TLR4 IL10 HMGB1
27 defense response to fungus GO:0050832 9.85 S100A9 MPO IL17A
28 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 TNF TLR4 MMP8 IL1B HMGB1
29 cytokine-mediated signaling pathway GO:0019221 9.85 TNF MMP9 LBP IL6 IL1B IL17A
30 positive regulation of JAK-STAT cascade GO:0046427 9.84 TNF IL6 IL10
31 positive regulation of DNA binding GO:0043388 9.84 MMP9 MMP8 HMGB1
32 acute-phase response GO:0006953 9.84 ORM1 LBP IL6 CRP
33 negative regulation of neurogenesis GO:0050768 9.83 TNF IL6 IL1B
34 negative regulation of interleukin-6 production GO:0032715 9.83 TNF TLR4 ORM1 IL10
35 positive regulation of glial cell proliferation GO:0060252 9.81 TNF IL6 IL1B
36 positive regulation of interleukin-8 production GO:0032757 9.81 TNF TLR4 LBP IL1B
37 positive regulation of macrophage activation GO:0043032 9.8 TLR4 LBP IL10
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.8 TNF IL1B IL10
39 positive regulation of interleukin-6 production GO:0032755 9.8 TNF TLR4 MMP8 LBP IL6 IL1B
40 positive regulation of chemokine production GO:0032722 9.78 TNF TLR4 LBP IL6
41 regulation of neuroinflammatory response GO:0150077 9.77 MMP9 MMP8 IL6
42 positive regulation of interleukin-6 secretion GO:2000778 9.77 TNF TLR4 IL1B IL17A HMGB1
43 negative regulation of lipid storage GO:0010888 9.76 TNF IL6 CRP
44 cellular response to lipoteichoic acid GO:0071223 9.73 TLR4 LBP
45 positive regulation of neuroinflammatory response GO:0150078 9.73 TNF MMP8 IL6 IL1B
46 positive regulation of MHC class II biosynthetic process GO:0045348 9.72 TLR4 IL10
47 positive regulation of interleukin-1 secretion GO:0050716 9.72 ORM1 HMGB1
48 opsonization GO:0008228 9.72 LBP CRP
49 lipopolysaccharide-mediated signaling pathway GO:0031663 9.72 TNF TLR4 LBP IL1B CCL2
50 endothelial cell apoptotic process GO:0072577 9.71 TNF IL10

Molecular functions related to Appendicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 TNF IL6 IL1B IL17A IL10 HMGB1
2 lipopolysaccharide binding GO:0001530 9.13 TLR4 LBP HMGB1
Sources

Sources for Appendicitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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