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MCID: APP008
MIFTS: 64

Appendicitis

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Appendicitis

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MalaCards integrated aliases for Appendicitis:

Name: Appendicitis 12 76 55 43 44 15 73
Acute Appendicitis 12 55
Acute Appendicitis with Generalized Peritonitis 12
Acute Appendicitis with Peritoneal Abscess 12
Acute Appendicitis Nos 73

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 33


Sources

Summaries for Appendicitis

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MedlinePlus : 43 The appendix is a small, tube-like organ attached to the first part of the large intestine. It is located in the lower right part of the abdomen. It has no known function. A blockage inside of the appendix causes appendicitis. The blockage leads to increased pressure, problems with blood flow, and inflammation. If the blockage is not treated, the appendix can burst and spread infection into the abdomen. This causes a condition called peritonitis. The main symptom is pain in the abdomen, often on the right side. It is usually sudden and gets worse over time. Other symptoms may include Swelling in the abdomen Loss of appetite Nausea and vomiting Constipation or diarrhea Inability to pass gas Low fever Not everyone with appendicitis has all these symptoms. Appendicitis is a medical emergency. Treatment almost always involves removing the appendix. Anyone can get appendicitis, but it is more common among people 10 to 30 years old. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Appendicitis, also known as acute appendicitis, is related to diverticulitis and mesenteric lymphadenitis, and has symptoms including pain, nausea and vomiting. An important gene associated with Appendicitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Ertapenem and Menthol have been mentioned in the context of this disorder. Affiliated tissues include appendix, kidney and colon, and related phenotypes are cardiovascular system and homeostasis/metabolism

Disease Ontology : 12 A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has symptom pain, in the upper abdomen initially and later in the lower abdomen, has symptom nausea, has symptom vomiting and has symptom fever.

Wikipedia : 76 Appendicitis is inflammation of the appendix. Symptoms commonly include right lower abdominal pain,... more...

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Related Diseases for Appendicitis

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Diseases related to Appendicitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 529)
# Related Disease Score Top Affiliating Genes
1 diverticulitis 31.3 CRP MMP9 TNF
2 mesenteric lymphadenitis 30.8 CRP IL6 LBP
3 fasciitis 30.6 CXCL8 IL6 TNF
4 leukomalacia 30.5 IL6 TNF
5 lymphadenitis 30.4 CXCL8 IL10 IL1B TNF
6 familial mediterranean fever 30.2 CRP IL1B TNF
7 duodenal ulcer 30.2 CXCL8 IL1B TNF
8 inguinal hernia 30.1 IL6 MMP9 TIMP1
9 vaginitis 30.1 CXCL8 IL1B IL6
10 schistosomiasis 30.0 ALB IL10 TNF
11 placenta disease 30.0 CXCL8 IL1B IL6
12 tuberculous peritonitis 29.9 ALB CRP TNF
13 osteomyelitis 29.9 CXCL8 IL1B IL6 TNF
14 pelvic inflammatory disease 29.9 CRP MMP9 MPO
15 polyarteritis nodosa 29.8 CRP IL6 MPO
16 adult-onset still's disease 29.8 CRP IL1B IL6 TNF
17 ileitis 29.8 IL6 MPO TNF
18 aortitis 29.7 CRP MPO
19 crohn's disease 29.7 CRP IL10 IL1B IL6 TNF
20 peptic ulcer disease 29.6 CXCL8 IL10 IL1B TNF
21 brucellosis 29.6 CRP CXCL8 IL10 IL6 TNF
22 churg-strauss syndrome 29.4 IL10 MPO TNF
23 hemorrhagic fever 29.4 ALB IL10 IL6 TNF
24 dysentery 29.4 ALB CRP ENO2
25 vasculitis 29.4 CRP MPO TNF
26 perinatal necrotizing enterocolitis 29.3 CRP CXCL8 IL1B IL6 TNF
27 typhoid fever 29.2 ALB CRP IL1B IL6 TNF
28 prostatitis 29.2 CXCL8 IL10 IL1B IL6 TNF
29 reactive arthritis 29.2 CRP IL10 IL6 MMP8 TNF
30 acquired immunodeficiency syndrome 29.1 ALB IL10 IL1B IL6 TNF
31 arthritis 29.0 CXCL8 IL10 IL1B IL6 MMP9 TNF
32 peritonitis 28.8 ALB CRP CXCL8 IL10 IL1B IL6
33 colitis 28.7 CXCL8 IL10 IL1B IL6 MPO TNF
34 acute pancreatitis 28.7 CRP CXCL8 IL10 IL6 MPO
35 diabetes mellitus 28.7 ALB CRP IL1B IL6 TNF
36 aortic aneurysm, familial abdominal, 1 28.5 CRP IL1B IL6 MMP8 MMP9 TIMP1
37 chorioamnionitis 28.4 CRP CXCL8 IL1B IL6 MMP8 MMP9
38 otitis media 28.4 ALB CXCL8 IL10 IL1B IL6 TNF
39 pyelonephritis 28.2 ALB CRP CXCL8 IL10 IL1B IL6
40 ulcerative colitis 28.0 CRP CXCL8 IL10 IL1B IL6 MPO
41 gastroenteritis 28.0 ALB CRP CXCL8 IL10 IL1B IL6
42 kawasaki disease 27.9 ALB CRP IL10 IL6 MMP9 TIMP1
43 malaria 27.5 ALB CRP CXCL8 IL10 IL1B IL6
44 inflammatory bowel disease 26.8 ALB CRP CXCL8 IL10 IL1B IL6
45 appendicitis, proneness to 11.9
46 gastrointestinal stromal tumor 11.2
47 pseudomyxoma peritonei 11.2
48 goblet cell carcinoid 11.2
49 cold agglutinin disease 10.9 CRP IL6
50 scorpion envenomation 10.9 IL6 TNF

Graphical network of the top 20 diseases related to Appendicitis:



Diseases related to Appendicitis
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Symptoms & Phenotypes for Appendicitis

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Symptoms:

12
  • • pain
  • • nausea
  • • vomiting
  • • fever

UMLS symptoms related to Appendicitis:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

MGI Mouse Phenotypes related to Appendicitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 TNF IL6 CD19 CRP MMP9 MPO
2 homeostasis/metabolism MP:0005376 9.97 TNF IL6 ALB CD19 LBP MMP8
3 hematopoietic system MP:0005397 9.91 TNF IL6 LBP CD19 MMP9 MPO
4 digestive/alimentary MP:0005381 9.87 TNF ALB IL6 CD19 MMP9 DMBT1
5 immune system MP:0005387 9.73 IL6 CD19 LBP MMP8 CRP MMP9
6 neoplasm MP:0002006 9.32 IL6 ALB CD19 MMP8 MMP9 DMBT1
Sources

Drugs & Therapeutics for Appendicitis

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Drugs for Appendicitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 182)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ertapenem Approved, Investigational Phase 4,Phase 2,Early Phase 1,Not Applicable 153832-46-3 150610
2
Menthol Approved Phase 4,Phase 2,Not Applicable 2216-51-5 16666
3
Morphine Approved, Investigational Phase 4,Phase 1,Phase 2 57-27-2 5288826
4
Metronidazole Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 443-48-1 4173
5
Ropivacaine Approved Phase 4,Phase 1,Phase 2,Not Applicable 84057-95-4 71273 175805
6
Tazobactam Approved Phase 4,Not Applicable 89786-04-9 123630
7
Ceftriaxone Approved Phase 4,Not Applicable 73384-59-5 5479530 5361919
8
Ampicillin Approved, Vet_approved Phase 4,Not Applicable 69-53-4 6249
9
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
10
Bupivacaine Approved, Investigational Phase 4,Phase 2,Not Applicable 2180-92-9, 38396-39-3 2474
11
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
12
Piperacillin Approved Phase 4,Not Applicable 66258-76-2 43672
13
Tigecycline Approved Phase 4,Not Applicable 220620-09-7 5282044
14
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 26787-78-0 33613
15
Ofloxacin Approved Phase 4,Phase 2,Not Applicable 82419-36-1 4583
16
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
17
Aztreonam Approved Phase 4 78110-38-0 5362041 5742832
18
Levofloxacin Approved, Investigational Phase 4,Phase 2,Not Applicable 100986-85-4 149096
19 Analgesics Phase 4,Phase 3,Not Applicable
20 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
21 Narcotics Phase 4,Phase 3
22 Analgesics, Opioid Phase 4,Phase 3
23 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
24 Anesthetics, General Phase 4,Phase 3,Not Applicable
25 Anesthetics, Local Phase 4,Phase 1,Phase 2,Not Applicable
26 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
27 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
28 Hypnotics and Sedatives Phase 4,Phase 3,Not Applicable
29 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
30 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
31 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
32 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
33 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
34 Clavulanic Acid Phase 4,Phase 3,Phase 2,Not Applicable
35 Adrenergic Agents Phase 4,Not Applicable
36 Adrenergic Agonists Phase 4,Not Applicable
37 Adrenergic alpha-Agonists Phase 4,Not Applicable
38 Amoxicillin-Potassium Clavulanate Combination Phase 4,Phase 3,Phase 2,Not Applicable
39 Gentamicins Phase 4,Not Applicable
40 Neurotransmitter Agents Phase 4,Not Applicable
41 Cyclooxygenase 2 Inhibitors Phase 4
42 Cyclooxygenase Inhibitors Phase 4,Phase 3,Not Applicable
43 Analgesics, Non-Narcotic Phase 4,Phase 3,Not Applicable
44 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 2,Not Applicable
45 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
46 Topoisomerase Inhibitors Phase 4,Phase 2,Not Applicable
47 Piperacillin, tazobactam drug combination Phase 4,Not Applicable
48 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable
49 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Not Applicable
50 Antirheumatic Agents Phase 4,Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 210)
# Name Status NCT ID Phase Drugs
1 Antibiotics Versus Surgery in Acute Appendicitis Unknown status NCT01421901 Phase 4 Ertapenem
2 Safety and Efficacy of Single Daily Dose of Ceftriaxone and Metronidazole for Treatment of Complicated Appendicitis in Children Completed NCT01678365 Phase 4 ceftriaxone, metronidazole/ampicillin, gentamicin, and metronidazole
3 Effect of Pain Control on the Diagnosis of Acute Appendicitis on the Diagnostic Accuracy of General Surgeon Completed NCT00783016 Phase 4 Morphine
4 Morphine Analgesia in Patients With Acute Appendicitis Completed NCT00477061 Phase 4 Morphine
5 Non Operative Treatment for Acute Appendicitis Completed NCT01096927 Phase 4 Amoxicillin and Clavulanic Acid
6 A Comparison of UGBRS Block and Local Infiltration Completed NCT02352519 Phase 4
7 Laparoscopic Versus Open Appendectomy Completed NCT02867072 Phase 4
8 Appendicectomy Skin Closure Technique: Changing Paradigms (ASC) Completed NCT02625987 Phase 4
9 Choose the Best Concentration of Ropivacaine on TAP Block for Open Appendectomy in Children Completed NCT03005808 Phase 4 Ropivacaine
10 Wound Healing After Emergency Appendicectomy Completed NCT00913445 Phase 4
11 Wound Infection Alexis Wound Retractor Completed NCT00323453 Phase 4
12 Pain Post Abdominal Laparoscopy Prevention With Arcoxia Completed NCT00565682 Phase 4 etoricoxib 120 mg
13 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection Completed NCT00195351 Phase 4 tigecycline;ceftriaxone sodium + metronidazole
14 Study of Tomography of Nephrolithiasis Evaluation Completed NCT01451931 Phase 4
15 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection (cIAI) Completed NCT00230971 Phase 4 tigecycline;ceftriaxone plus metronidazole
16 Initial Non-operative Treatment Strategy Versus Appendectomy Treatment Strategy for Simple Appendicitis in Children Recruiting NCT02848820 Phase 4 Augmentin + Gentamicin
17 A Trial to Assess the Efficacy and Safety of Morinidazole in Patients With Appendicitis Recruiting NCT03380793 Phase 4 morinidazole
18 Intraperitoneal Dexmedetomidine for Post-laparoscopic Appendicectomy Pain Management in Children Recruiting NCT03067740 Phase 4 Bupivacaine;Dexmedetomidine
19 Wound Infiltration With Local Anesthetic Agent for Laparoscopic Appendectomy in Adult Not yet recruiting NCT03481517 Phase 4 Bupivacaine
20 A Study Comparing Safety and Efficacy of Levofloxacin and Metronidazole Versus Piperacillin/Tazobactam in Treating Complicated Appendicitis Terminated NCT00236912 Phase 4 levofloxacin; metronidazole
21 Study Comparing Early Laparoscopy With Active Observation in Acute Non-specific Abdominal Pain Terminated NCT01675466 Phase 4
22 Once Daily Metronidazole for Perforated Appendicitis Withdrawn NCT02561117 Phase 4 Metronidazole
23 Laparoscopic Appendectomy by Multi-port vs Single Port. Unknown status NCT01720082 Phase 3
24 The Onset Time of Rocuronium in Emergency and Elective Surgery Unknown status NCT02634255 Phase 3 Rocuronium elective surgery;Rocuronium emergency surgery;Propofol;Fentanyl
25 Feasibility of Outpatient Appendectomy for Acute Appendicitis Completed NCT01839435 Phase 3
26 Early Versus Interval Appendectomy for Ruptured Appendicitis in Children Completed NCT00435032 Phase 3
27 Efficacy Study of Delayed Primary Closure to Reduce Rate of Wound Infection in Complicated Appendicitis Completed NCT01659983 Phase 3
28 Diagnosis of Acute Appendicitis: Low-dose Computed Tomography (CT) Versus Standard-dose CT Completed NCT00913380 Phase 3
29 Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures Completed NCT01524081 Phase 3 Metronidazole, Cefuroxime;Amoxicillin (+ clavulanic acid) and Fluconazole;Placebo;Placebo
30 Laparoscopic Appendectomy for Chronic Right Lower Abdominal Pain Completed NCT00413855 Phase 3
31 Single Incision Versus Conventional Laparoscopic Appendectomy Completed NCT01515293 Phase 3
32 A Randomised Controlled Trial on LESS Versus Conventional Laparoscopic Appendicectomy. Completed NCT01203566 Phase 3
33 Efficacy and Safety Study of Eravacycline Compared With Meropenem in Complicated Intra-abdominal Infections Completed NCT02784704 Phase 3 Eravacycline;Meropenem;Placebo
34 Doripenem in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00229060 Phase 3 doripenem
35 Doripenem in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00210938 Phase 3 Doripenem
36 Sublingual Analgesia for Acute Abdominal Pain in Children Completed NCT02465255 Phase 3 Ketorolac;Tramadol;Acetaminophen
37 Safety and Efficacy of Albiglutide + Insulin Glargine Versus Insulin Lispro + Insulin Glargine Subjects With Type 2 Diabetes Mellitus Completed NCT02229227 Phase 3 Albiglutide;Insulin Glargine and Insulin Lispro
38 A Safety and Tolerability Study of Doripenem Compared With Meropenem in Children Hospitalized With Complicated Intra-abdominal Infections Terminated NCT01110382 Phase 3 Doripenem;Meropenem placebo;Meropenem;Doripenem placebo;Amoxicillin/clavulanate potassium
39 Nebulized Analgesia for Laparoscopic Appendectomy Trial Unknown status NCT02624089 Phase 1, Phase 2 Ropivacaine;Normal saline
40 Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis Completed NCT02664220 Phase 2 Povidone-iodine irrigation
41 Study of Conservative Versus Surgical Treatment of Appendicitis Completed NCT00469430 Phase 2 cefotaxim and metronidazol
42 The Safety and Pharmacokinetics of Intraperitoneal Administration in Patients Undergoing Appendectomy for Uncomplicated Appendicitis Completed NCT03046758 Phase 2 A combination of fosfomycin, metronidazole and GM-CSF i.p.
43 Preoperative Methylprednisolone to Patients Suspected of Appendicitis Undergoing Laparoscopy Completed NCT02711449 Phase 2 Methylprednisolone;0.9% Saline
44 Dexamethasone Preoperative for Patients Undergoing Laparoscopy for Suspected Appendicitis Completed NCT02415335 Phase 2 dexamethasone phosphate;Isotonic NaCl
45 Laparoscopic Management of Periappendicular Abscess Completed NCT01283815 Phase 2
46 Conservative Versus Operative ManageMent of Acute Uncomplicated Appendicitis Recruiting NCT02916134 Phase 2 Antibiotic treatment
47 Intraperitoneal Administration of Fosfomycin, Metronidazole and Molgramostim Versus Intravenous Antibiotics for Perforated Appendicitis Recruiting NCT03435900 Phase 2 Combination of fosfomycin, metronidazole and rhGM-CSF (administered together intraperitoneally) and three days of antibiotics p.o.;Standard antibiotics intravenously
48 Narcotic vs. Non-narcotic Pain Regimens After Pediatric Appendectomy Recruiting NCT03528343 Phase 1, Phase 2 Non-narcotic pain control
49 Clinical Trial Comparing ERAT vs Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis Not yet recruiting NCT02789865 Phase 2 Ertapenem, Levofloxacin and Metronidazole
50 Transversus Abdominis Plane (TAP) Versus Local Anesthetic for Lap Appendectomies Terminated NCT01575028 Phase 2 Ropivacaine;Bupivacaine

Search NIH Clinical Center for Appendicitis

Cochrane evidence based reviews: appendicitis

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Genetic Tests for Appendicitis

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Anatomical Context for Appendicitis

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MalaCards organs/tissues related to Appendicitis:

41
Appendix, Kidney, Colon, Testes, Liver, Bone, Neutrophil
Sources

Publications for Appendicitis

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Articles related to Appendicitis:

(show top 50) (show all 1077)
# Title Authors Year
1
Parasitic Appendicitis: A Novel Laparoscopic Approach for the Prevention of Peritoneal Contamination. ( 29977414 )
2018
2
The RIPASA score for the diagnosis of acute appendicitis: A comparison with the modified Alvarado score. ( 29426650 )
2018
3
Acute appendicitis in leukaemia patients undergoing haematopoietic stem cell transplantation during the neutropaenic phase: a case series from a single BMT centre in China. ( 29410536 )
2018
4
Evaluation of Diagnostic Scores for Acute Appendicitis. ( 29394968 )
2018
5
Suspicion of appendicitis in pregnant women: emergency evaluation by sonography and low-dose CT with oral contrast. ( 29948087 )
2018
6
Burkitt's lymphoma presenting as acute appendicitis: a case report. ( 29942479 )
2018
7
Pus Samples in Complicated Appendicitis: An Important Investigation or a Waste of Resources: A Prospective Cohort Study. ( 29973114 )
2018
8
Endoloop versus endostapler: what is the best option for appendiceal stump closure in children with complicated appendicitis? Results of a multicentric international survey. ( 29404732 )
2018
9
Don't be short-sighted: cervical incompetence in a pregnant patient with acute appendicitis. ( 29414522 )
2018
10
Ileal Cystic Lymphangioma presenting with Acute Appendicitis. ( 29386763 )
2018
11
Laparoscopic appendectomy for the treatment of acute appendicitis: a single center experience. ( 29393074 )
2018
12
Acute Appendicitis as an Unexpected Cause of Inverted Takotsubo Cardiomyopathy. ( 29937647 )
2018
13
Questionable Assumptions Provided in Nonoperative Treatment of Appendicitis Survey. ( 29971340 )
2018
14
Acute appendicitis complicated with necrotizing fasciitis in a patient with adult-onset Still's disease: A case report. ( 29384877 )
2018
15
Efficacy of Strain Elastography in Diagnosis and Staging of Acute Appendicitis in Pediatric Patients. ( 29428963 )
2018
16
Effect of Delay to Operation on Outcomes in Patients with Acute Appendicitis: a Systematic Review and Meta-analysis. ( 29980978 )
2018
17
Non-operative treatment of appendicitis: public perception and decision-making. ( 29423825 )
2018
18
Different manifestation of a familiar diagnosis: From anuria to acute appendicitis. ( 29510913 )
2018
19
An Ulcerated Ileal Gastrointestinal Stromal Tumor Disguised as Acute Appendicitis. ( 29971179 )
2018
20
Clinical prediction score for superficial surgical site infection after appendectomy in adults with complicated appendicitis. ( 29946346 )
2018
21
An Unusual Case of Inflammatory Myofibroblastic Tumor of the Appendix Masquerading as Acute Appendicitis. ( 29896334 )
2018
22
Atypical presentation of type B aortic dissection mimicking appendicitis managed medically. ( 29960968 )
2018
23
Accuracy of ultrasound exam performed by emergency medicine versus radiology residents in the diagnosis of acute appendicitis. ( 29438133 )
2018
24
Gangrenous giant Meckel's diverticulitis masquerading acute appendicitis: a surgical conundrum. ( 29695030 )
2018
25
Is there a role for routine colonoscopy in the follow-up after acute appendicitis? ( 29979091 )
2018
26
Ultrasound and computed tomography of sacculitis and appendicitis in a rabbit. ( 29393561 )
2018
27
Appendicitis in the HIV Era: a South African perspective. ( 29973748 )
2018
28
Questionable Assumptions Provided in Nonoperative Treatment of Appendicitis Survey-Reply. ( 29971345 )
2018
29
Surgeon-Performed Ultrasound in Diagnosing Acute Cholecystitis and Appendicitis. ( 29882098 )
2018
30
Economic Analysis of Diagnostic Imaging in Pediatric Patients with Suspected Appendicitis. ( 29427374 )
2018
31
Diagnostic accuracy of surgeon performed ultrasound (SPU) for appendicitis in children. ( 29980345 )
2018
32
Acute enterocolitis causing an appendicitis like symdrome. ( 29932094 )
2018
33
Appendiceal outer diameter as an indicator of acute appendicitis in young children. ( 29428695 )
2018
34
A case of De Garengeot's hernia with acute appendicitis and literature review. ( 29960210 )
2018
35
Ulysses Syndrome: The Modern-day Odyssey of Pediatric Patients With Uncomplicated Acute Appendicitis. ( 29401107 )
2018
36
Analysis of Appendiceal Neoplasms on 3544 Appendectomy Specimens for Acute Appendicitis: Retrospective Cohort Study of a Single Institution. ( 29947345 )
2018
37
Appendicitis Grade, Operative Duration, and Hospital Cost. ( 29391281 )
2018
38
Acute single appendicitis in a female with a duplicated appendix. ( 29942480 )
2018
39
Drain Failure in Intra-Abdominal Abscesses Associated with Appendicitis. ( 29431586 )
2018
40
Acute eosinophilic appendicitis: a radiologic-pathologic correlation. ( 29960267 )
2018
41
Acute Appendicitis as the Initial Clinical Presentation of Primary HIV-1 Infection. ( 29423422 )
2018
42
Population-based cohort study on the epidemiology of acute appendicitis in children in Sweden in 1987-2013. ( 29951638 )
2018
43
Imaging Approach to the Diagnosis of Acute Appendicitis in a Group of Teaching Hospitals With 24/7 In-house Availability of Ultrasound Technologist: Effect of Timing of Request on Imaging Modality. ( 29958834 )
2018
44
Acute appendicitis due to schistosomiasis: four cases at the Yalgado OuAcdraogo University Hospital of Ouagadougou. ( 28947413 )
2017
45
Operative versus non-operative management in the care of patients with complicated appendicitis. ( 28941724 )
2017
46
Acute Appendicitis: An Extracolonic Manifestation of Clostridium difficile Colitis. ( 28757875 )
2017
47
An unusual cause of acute appendicitis in New Zealand. ( 28081559 )
2017
48
Evaluation of the Alvarado scoring system in the management of acute appendicitis. ( 28944334 )
2017
49
Antibiotics Versus Surgical Therapy for Uncomplicated Appendicitis: Contrasting Interpretations of Data. ( 28938269 )
2017
50
Imaging is Usually Not Necessary When Clinical Scores for the Diagnosis of Appendicitis Are Low. ( 28005500 )
2017
Sources

Variations for Appendicitis

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Expression for Appendicitis

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Search GEO for disease gene expression data for Appendicitis.
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Pathways for Appendicitis

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Pathways related to Appendicitis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.98 CD19 CRP CXCL8 IL10 IL1B IL6
2
Cytokine Signaling in Immune system 66
Show member pathways
 13.35 CXCL8 IL10 IL1B IL6 LBP MMP9
3
PAK Pathway 64
Show member pathways
 13.26 CXCL8 IL10 IL1B IL6 TIMP1 TNF
4
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 13.01 CXCL8 IL10 IL1B IL6 LBP TNF
5
Allograft rejection 1 37
Show member pathways
 12.85 CXCL8 IL10 IL1B IL6 TNF
6
Regulation of IFNA signaling 66
Show member pathways
 12.66 CXCL8 IL10 IL1B IL6 TNF
7
NF-kappaB Signaling 4
12.59 CD19 IL10 IL1B MPO TNF
8
Immune response IL-23 signaling pathway 22
Show member pathways
 12.58 IL10 IL1B IL6 MPO TIMP1 TNF
9
Kaposi's sarcoma-associated herpesvirus infection 37
Show member pathways
 12.54 CXCL8 IL6 MMP9 TNF
10
Th17 cell differentiation 37
Show member pathways
 12.43 IL10 IL1B IL6 TNF
11
T cell receptor signaling pathway 37
Show member pathways
 12.42 IL10 IL1B IL6 TNF
12
IL-17 Family Signaling Pathways 65
Show member pathways
 12.35 CXCL8 IL1B IL6 MMP9 TNF
13
Toll Comparative Pathway 64
Show member pathways
 12.29 CXCL8 IL1B IL6 LBP TNF
14
Th1 Differentiation Pathway 65
Show member pathways
 12.28 IL10 IL1B IL6 TNF
15
Transcriptional misregulation in cancer 37
12.27 CXCL8 IL6 MMP9 MPO
16
Folate Metabolism 1
Show member pathways
 12.27 ALB CRP IL1B IL6 MPO TNF
17
Tuberculosis 37
12.26 IL10 IL1B IL6 LBP TNF
18
IL-1 Family Signaling Pathways 65
Show member pathways
 12.24 CXCL8 IL1B IL6 TNF
19
C-type lectin receptor signaling pathway 37
Show member pathways
 12.23 IL10 IL1B IL6 TNF
20
Bacterial infections in CF airways 22
Show member pathways
 12.21 CXCL8 IL1B IL6 LBP TNF
21
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.19 CXCL8 IL10 IL1B IL6 TNF
22
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.1 CXCL8 IL10 IL1B IL6 TIMP1
23
Spinal Cord Injury 1
12.02 CXCL8 IL1B IL6 MMP9 TNF
24
TNF signaling pathway 37
12 IL1B IL6 MMP9 TNF
25
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
12 CD19 IL10 IL6 MPO TNF
26
AGE-RAGE signaling pathway in diabetic complications 37
11.96 CXCL8 IL1B IL6 TNF
27
Matrix Metalloproteinases 1
Show member pathways
 11.95 MMP8 MMP9 TIMP1 TNF
28
Hematopoietic cell lineage 37
11.94 CD19 IL1B IL6 TNF
29
NF-kappa B signaling pathway 37
11.93 CXCL8 IL1B LBP TNF
30
Senescence and Autophagy in Cancer 1
11.92 CXCL8 IL1B IL6
31
HIF-1 signaling pathway 37
11.89 ENO2 IL6 TIMP1
32
Rheumatoid arthritis 37
11.89 CXCL8 IL1B IL6 TNF
33
IL6-mediated signaling events 1
Show member pathways
 11.87 CRP IL6 LBP TIMP1
34
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.86 CXCL8 IL6 LBP
35
Salmonella infection (KEGG) 37
11.86 CXCL8 IL1B IL6 LBP
36
Amoebiasis 37
11.86 CXCL8 IL10 IL1B IL6 TNF
37
Innate Lymphoid Cell Differentiation Pathways 65
11.79 IL10 IL1B TNF
38
Pertussis 37
11.71 CXCL8 IL10 IL1B IL6 TNF
39
LPA receptor mediated events 1
11.69 CXCL8 IL6 MMP9
40
Dendritic Cells Developmental Lineage Pathway 65
11.67 CD19 IL10 IL1B IL6 TNF
41
Cell adhesion_ECM remodeling 22
11.66 CXCL8 MMP9 TIMP1
42
Legionellosis 37
11.62 CXCL8 IL1B IL6 TNF
43
amb2 Integrin signaling 1
11.54 IL6 MMP9 MPO TNF
44
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.52 IL1B IL6 TNF
45
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.52 CXCL8 IL1B IL6 MMP9 TNF
46
Lung fibrosis 1
11.43 CXCL8 IL1B IL6 MMP9 TIMP1 TNF
47
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.39 CXCL8 IL6 MMP9
48
African trypanosomiasis 37
11.37 IL10 IL1B IL6 TNF
49
Development and heterogeneity of the ILC family 1
11.36 IL1B IL6 TNF
50
IL-10 Pathway 64
11.36 IL10 IL1B IL6 TNF
Sources

GO Terms for Appendicitis

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Cellular components related to Appendicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.85 ALB CD19 CRP DMBT1 ENO2 IL1B
2 extracellular region GO:0005576 9.77 ALB CRP CXCL8 DMBT1 IL10 IL1B
3 extracellular matrix GO:0031012 9.56 DMBT1 MMP8 MMP9 TIMP1
4 extracellular space GO:0005615 9.47 ALB CRP CXCL8 DMBT1 ENO2 IL10

Biological processes related to Appendicitis according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.95 CXCL8 IL10 IL1B IL6 TIMP1 TNF
2 defense response to bacterium GO:0042742 9.92 IL10 LBP MPO TNF
3 cellular protein metabolic process GO:0044267 9.92 ALB DMBT1 IL6 TIMP1
4 inflammatory response GO:0006954 9.91 CRP CXCL8 IL10 IL1B IL6 TNF
5 defense response GO:0006952 9.88 CXCL8 DMBT1 MPO TNF
6 response to organic substance GO:0010033 9.85 IL10 TIMP1 TNF
7 response to lipopolysaccharide GO:0032496 9.85 CXCL8 IL10 IL1B LBP MPO
8 defense response to Gram-negative bacterium GO:0050829 9.84 DMBT1 IL6 LBP
9 extracellular matrix disassembly GO:0022617 9.83 MMP8 MMP9 TIMP1
10 positive regulation of DNA binding transcription factor activity GO:0051091 9.81 IL10 IL1B IL6 TNF
11 response to glucocorticoid GO:0051384 9.8 IL10 IL6 TNF
12 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.77 IL10 MMP9 TNF
13 acute-phase response GO:0006953 9.73 CRP IL6 LBP
14 lipopolysaccharide-mediated signaling pathway GO:0031663 9.72 IL1B LBP TNF
15 positive regulation of interleukin-8 production GO:0032757 9.7 IL1B LBP TNF
16 embryonic digestive tract development GO:0048566 9.68 CXCL8 TNF
17 negative regulation of lipid catabolic process GO:0050995 9.68 IL1B TNF
18 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.68 IL1B TNF
19 positive regulation of macrophage activation GO:0043032 9.67 IL10 LBP
20 response to molecule of bacterial origin GO:0002237 9.67 CXCL8 IL10
21 positive regulation of chemokine production GO:0032722 9.67 IL6 LBP TNF
22 positive regulation of interleukin-6 production GO:0032755 9.67 IL1B IL6 LBP TNF
23 opsonization GO:0008228 9.65 CRP LBP
24 positive regulation of chemokine biosynthetic process GO:0045080 9.65 IL1B TNF
25 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.65 IL10 TIMP1
26 cellular response to lipopolysaccharide GO:0071222 9.65 CXCL8 IL10 IL6 LBP TNF
27 endothelial cell apoptotic process GO:0072577 9.64 IL10 TNF
28 regulation of establishment of endothelial barrier GO:1903140 9.63 IL1B TNF
29 negative regulation of cytokine secretion involved in immune response GO:0002740 9.61 IL10 TNF
30 positive regulation of fever generation GO:0031622 9.61 IL1B TNF
31 sequestering of triglyceride GO:0030730 9.6 IL1B TNF
32 receptor biosynthetic process GO:0032800 9.58 IL10 TNF
33 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL10 IL1B TNF
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.57 IL1B TNF
35 defense response to Gram-positive bacterium GO:0050830 9.55 CRP DMBT1 IL6 LBP TNF
36 negative regulation of lipid storage GO:0010888 9.5 CRP IL6 TNF
37 negative regulation of growth of symbiont in host GO:0044130 9.26 IL10 LBP MPO TNF
38 cytokine-mediated signaling pathway GO:0019221 9.23 CXCL8 IL10 IL1B IL6 LBP MMP9
39 immune response GO:0006955 10.04 CXCL8 IL10 IL1B IL6 TNF
40 negative regulation of apoptotic process GO:0043066 10.01 ALB IL10 IL6 MMP9 MPO TIMP1

Molecular functions related to Appendicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CXCL8 IL10 IL1B IL6 TIMP1 TNF
Sources

Sources for Appendicitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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