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MCID: APP008
MIFTS: 65

Appendicitis

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Appendicitis

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MalaCards integrated aliases for Appendicitis:

Name: Appendicitis 12 76 55 43 44 15 73
Acute Appendicitis 12 55 15
Acute Appendicitis with Generalized Peritonitis 12
Acute Appendicitis with Peritoneal Abscess 12
Acute Appendicitis Nos 73

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:8337
ICD9CM 35 540-543.99 541
MeSH 44 D001064
NCIt 50 C35145
SNOMED-CT 68 74400008
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Summaries for Appendicitis

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MedlinePlus : 43 The appendix is a small, tube-like organ attached to the first part of the large intestine. It is located in the lower right part of the abdomen. It has no known function. A blockage inside of the appendix causes appendicitis. The blockage leads to increased pressure, problems with blood flow, and inflammation. If the blockage is not treated, the appendix can burst and spread infection into the abdomen. This causes a condition called peritonitis. The main symptom is pain in the abdomen, often on the right side. It is usually sudden and gets worse over time. Other symptoms may include Swelling in the abdomen Loss of appetite Nausea and vomiting Constipation or diarrhea Inability to pass gas Low fever Not everyone with appendicitis has all these symptoms. Appendicitis is a medical emergency. Treatment almost always involves removing the appendix. Anyone can get appendicitis, but it is more common among people 10 to 30 years old. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Appendicitis, also known as acute appendicitis, is related to peritonitis and diverticulitis, and has symptoms including fever, vomiting and pain. An important gene associated with Appendicitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Ertapenem and Metronidazole have been mentioned in the context of this disorder. Affiliated tissues include appendix, kidney and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has symptom pain, in the upper abdomen initially and later in the lower abdomen, has symptom nausea, has symptom vomiting and has symptom fever.

Wikipedia : 76 Appendicitis is inflammation of the appendix. Symptoms commonly include right lower abdominal pain,... more...

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Related Diseases for Appendicitis

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Diseases related to Appendicitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 616)
# Related Disease Score Top Affiliating Genes
1 peritonitis 31.0 ALB CRP CXCL8 IL10 IL1B IL6
2 diverticulitis 30.8 CRP MMP9 TNF
3 mesenteric lymphadenitis 30.6 CRP IL6 LBP
4 purpura 30.5 CRP IL6 TNF
5 inguinal hernia 30.4 IL6 MMP9 TIMP1
6 fasciitis 30.4 CXCL8 IL6 TNF
7 endometriosis 30.4 CXCL8 IL1B IL6
8 schistosomiasis 30.3 ALB IL10 TNF
9 lymphadenitis 30.2 CXCL8 IL10 IL1B TNF
10 familial mediterranean fever 30.1 CRP IL1B TNF
11 ileitis 30.0 IL6 MPO TNF
12 rheumatic fever 29.9 IL10 IL6 TNF
13 duodenal ulcer 29.9 CXCL8 IL1B TNF
14 pelvic inflammatory disease 29.8 CRP MMP9 MPO
15 leukomalacia 29.8 IL6 TNF
16 perinatal necrotizing enterocolitis 29.8 CRP CXCL8 IL1B IL6 TNF
17 acquired immunodeficiency syndrome 29.7 ALB IL10 IL1B IL6 TNF
18 colitis 29.7 CXCL8 IL10 IL1B IL6 MPO TNF
19 pyelitis 29.7 CRP CXCL8 IL6
20 castleman disease 29.7 CRP IL10 IL6
21 hematopoietic stem cell transplantation 29.7 IL10 IL6 TNF
22 osteomyelitis 29.7 CXCL8 IL10 IL1B IL6 TNF
23 pharyngitis 29.7 CRP CXCL8 IL1B
24 placenta disease 29.6 CXCL8 IL1B IL6
25 peptic ulcer disease 29.6 CXCL8 IL10 IL1B TNF
26 polyarteritis nodosa 29.6 CRP IL6 MPO
27 tuberculous peritonitis 29.6 ALB CRP TNF
28 arthritis 29.5 CXCL8 IL10 IL1B IL6 MMP9 TNF
29 aortitis 29.5 CRP MPO
30 gastric adenocarcinoma 29.5 CXCL8 IL1B MMP9 TNF
31 adult-onset still's disease 29.5 CRP IL1B IL6 TNF
32 brain injury 29.5 ENO2 IL10 IL6
33 traumatic brain injury 29.5 ENO2 IL10 IL6
34 typhoid fever 29.5 ALB CRP IL1B IL6 TNF
35 reactive arthritis 29.5 CRP IL10 MMP8 TNF
36 tonsillitis 29.4 CXCL8 IL1B IL6 TNF
37 hemorrhagic fever 29.4 ALB IL10 IL6 TNF
38 dysentery 29.4 ALB CRP ENO2
39 vasculitis 29.4 CRP MPO TNF
40 visceral leishmaniasis 29.3 ALB CXCL8 IL10 TNF
41 viral infectious disease 29.3 CXCL8 IL10 IL1B IL6 TNF
42 diabetes mellitus 29.3 ALB CRP IL1B IL6 TNF
43 leishmaniasis 29.3 CXCL8 IL10 IL1B IL6 TNF
44 chorioamnionitis 29.3 CRP CXCL8 IL1B IL6 MMP8 MMP9
45 microscopic polyangiitis 29.3 IL10 MPO TNF
46 bone inflammation disease 29.2 CRP CXCL8 IL10 IL1B IL6 TIMP1
47 ulcerative colitis 29.2 CRP CXCL8 IL10 IL1B IL6 MPO
48 pyelonephritis 29.2 ALB CRP CXCL8 IL10 IL1B IL6
49 gastroenteritis 29.2 ALB CRP CXCL8 IL10 IL1B IL6
50 aortic aneurysm, familial abdominal, 1 29.1 CRP IL1B IL6 MMP8 MMP9 TIMP1

Graphical network of the top 20 diseases related to Appendicitis:



Diseases related to Appendicitis
Sources

Symptoms & Phenotypes for Appendicitis

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Symptoms:

12
  • • fever
  • • vomiting
  • • pain
  • • nausea

UMLS symptoms related to Appendicitis:


nausea and vomiting, constipation, abdominal pain, diarrhea, icterus, dyspepsia, heartburn, gastrointestinal gas

GenomeRNAi Phenotypes related to Appendicitis according to GeneCards Suite gene sharing:

26 (show all 28)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.85 MMP8 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.85 MPO
3 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.85 LBP
4 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.85 LBP
5 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.85 LBP
6 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.85 MPO
7 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.85 HMGB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.85 LBP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.85 HMGB1 LBP MMP8 MPO
10 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.85 MPO
11 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.85 MMP8
12 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.85 MMP8
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.85 MPO
14 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.85 MPO
15 Increased shRNA abundance (Z-score > 2) GR00366-A-41 9.85 MMP8
16 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.85 LBP MMP8
17 Increased shRNA abundance (Z-score > 2) GR00366-A-51 9.85 LBP
18 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.85 MMP8
19 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.85 MPO
20 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.85 HMGB1 LBP
21 Increased shRNA abundance (Z-score > 2) GR00366-A-69 9.85 HMGB1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.85 MPO
23 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.85 MPO
24 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.85 LBP
25 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.85 MMP8
26 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.85 HMGB1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.85 LBP
28 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.85 MMP8

MGI Mouse Phenotypes related to Appendicitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 CD19 CRP IL10 IL1B IL6 MMP9
2 homeostasis/metabolism MP:0005376 9.93 ALB CD19 CRP IL10 IL1B IL6
3 hematopoietic system MP:0005397 9.91 CD19 IL10 IL1B IL6 LBP MMP9
4 immune system MP:0005387 9.7 CD19 CRP IL10 IL1B IL6 LBP
5 neoplasm MP:0002006 9.32 ALB CD19 IL10 IL1B IL6 LRG1
Sources

Drugs & Therapeutics for Appendicitis

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Drugs for Appendicitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 203)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ertapenem Approved, Investigational Phase 4,Phase 2,Early Phase 1,Not Applicable 153832-46-3 150610
2
Metronidazole Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 443-48-1 4173
3
Morphine Approved, Investigational Phase 4,Phase 1,Phase 2 57-27-2 5288826
4
Ropivacaine Approved Phase 4,Phase 1,Phase 2,Not Applicable 84057-95-4 175805 71273
5
Ceftriaxone Approved Phase 4,Not Applicable 73384-59-5 5479530 5361919
6
Ampicillin Approved, Vet_approved Phase 4,Not Applicable 69-53-4 6249
7
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 26787-78-0 33613
8
Bupivacaine Approved, Investigational Phase 4,Phase 2,Not Applicable 2180-92-9, 38396-39-3 2474
9
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
10
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
11
Tigecycline Approved Phase 4,Not Applicable 220620-09-7 5282044
12
Piperacillin Approved Phase 4,Phase 2,Not Applicable 66258-76-2 43672
13
Tazobactam Approved Phase 4,Phase 2,Not Applicable 89786-04-9 123630
14
Aztreonam Approved Phase 4 78110-38-0 5362041 5742832
15
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
16
Ofloxacin Approved Phase 4,Phase 2,Not Applicable 82419-36-1 4583
17
Levofloxacin Approved, Investigational Phase 4,Phase 2,Not Applicable 100986-85-4 149096
18 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
19 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
20 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
21 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
22 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
23 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
24 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
25 Analgesics, Opioid Phase 4,Phase 3
26 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
27 Narcotics Phase 4,Phase 3,Phase 1,Phase 2
28 Analgesics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
29 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
30 Anesthetics, Local Phase 4,Phase 1,Phase 2,Not Applicable
31 Hypnotics and Sedatives Phase 4,Phase 3,Not Applicable
32 Anesthetics, General Phase 4,Phase 3,Not Applicable
33 Gentamicins Phase 4,Not Applicable
34 Clavulanic Acids Phase 4,Phase 3,Phase 2,Not Applicable
35 beta-Lactamase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
36 Cyclooxygenase 2 Inhibitors Phase 4
37 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Not Applicable
38 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable
39 Cyclooxygenase Inhibitors Phase 4,Phase 3,Not Applicable
40 Antirheumatic Agents Phase 4,Phase 3,Not Applicable
41 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
42 Amoxicillin-Potassium Clavulanate Combination Phase 4,Phase 3,Phase 2,Not Applicable
43 Adrenergic Agents Phase 4,Not Applicable
44 Adrenergic alpha-Agonists Phase 4,Not Applicable
45 Neurotransmitter Agents Phase 4,Not Applicable
46 Adrenergic Agonists Phase 4,Not Applicable
47 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
48 Piperacillin, tazobactam drug combination Phase 4,Not Applicable
49 Topoisomerase Inhibitors Phase 4,Phase 2,Not Applicable
50 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 228)
# Name Status NCT ID Phase Drugs
1 Antibiotics Versus Surgery in Acute Appendicitis Unknown status NCT01421901 Phase 4 Ertapenem
2 Safety and Efficacy of Single Daily Dose of Ceftriaxone and Metronidazole for Treatment of Complicated Appendicitis in Children Completed NCT01678365 Phase 4 ceftriaxone, metronidazole/ampicillin, gentamicin, and metronidazole
3 Effect of Pain Control on the Diagnosis of Acute Appendicitis on the Diagnostic Accuracy of General Surgeon Completed NCT00783016 Phase 4 Morphine
4 Morphine Analgesia in Patients With Acute Appendicitis Completed NCT00477061 Phase 4 Morphine
5 Non Operative Treatment for Acute Appendicitis Completed NCT01096927 Phase 4 Amoxicillin and Clavulanic Acid
6 A Comparison of UGBRS Block and Local Infiltration Completed NCT02352519 Phase 4
7 Laparoscopic Versus Open Appendectomy Completed NCT02867072 Phase 4
8 Appendicectomy Skin Closure Technique: Changing Paradigms (ASC) Completed NCT02625987 Phase 4
9 Choose the Best Concentration of Ropivacaine on TAP Block for Open Appendectomy in Children Completed NCT03005808 Phase 4 Ropivacaine
10 Wound Healing After Emergency Appendicectomy Completed NCT00913445 Phase 4
11 Pain Post Abdominal Laparoscopy Prevention With Arcoxia Completed NCT00565682 Phase 4 etoricoxib 120 mg
12 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection Completed NCT00195351 Phase 4 tigecycline;ceftriaxone sodium + metronidazole
13 Study of Tomography of Nephrolithiasis Evaluation Completed NCT01451931 Phase 4
14 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection (cIAI) Completed NCT00230971 Phase 4 tigecycline;ceftriaxone plus metronidazole
15 Initial Non-operative Treatment Strategy Versus Appendectomy Treatment Strategy for Simple Appendicitis in Children Recruiting NCT02848820 Phase 4 Augmentin + Gentamicin
16 A Trial to Assess the Efficacy and Safety of Morinidazole in Patients With Appendicitis Recruiting NCT03380793 Phase 4 morinidazole
17 Wound Infiltration With Local Anesthetic Agent for Laparoscopic Appendectomy in Adult Recruiting NCT03481517 Phase 4 Bupivacaine
18 Intraperitoneal Dexmedetomidine for Post-laparoscopic Appendicectomy Pain Management in Children Recruiting NCT03067740 Phase 4 Bupivacaine;Dexmedetomidine
19 COMPARISON OF TRANSVERSUS ABDOMINIS PLANE BLOCK, LOCAL ANESTHETIC INJECTION TO THE PORT SITES AND INTRAPERITONEAL LOCAL ANESTHESIA APPLICATIONS IN POSTOPERATIVE PAIN MANAGEMENT IN PATIENTS WITH LAPAROSCOPIC APPENDECTOMY Active, not recruiting NCT03790020 Phase 4 Bupivacaine
20 Antibiotic Duration in Post-appendectomy Abscess Not yet recruiting NCT03795194 Phase 4 ampicillin/clavulanate
21 A Study Comparing Safety and Efficacy of Levofloxacin and Metronidazole Versus Piperacillin/Tazobactam in Treating Complicated Appendicitis Terminated NCT00236912 Phase 4 levofloxacin; metronidazole
22 Study Comparing Early Laparoscopy With Active Observation in Acute Non-specific Abdominal Pain Terminated NCT01675466 Phase 4
23 Once Daily Metronidazole for Perforated Appendicitis Withdrawn NCT02561117 Phase 4 Metronidazole
24 Laparoscopic Appendectomy by Multi-port vs Single Port. Unknown status NCT01720082 Phase 3
25 The Onset Time of Rocuronium in Emergency and Elective Surgery Unknown status NCT02634255 Phase 3 Rocuronium elective surgery;Rocuronium emergency surgery;Propofol;Fentanyl
26 Feasibility of Outpatient Appendectomy for Acute Appendicitis Completed NCT01839435 Phase 3
27 Early Versus Interval Appendectomy for Ruptured Appendicitis in Children Completed NCT00435032 Phase 3
28 Efficacy Study of Delayed Primary Closure to Reduce Rate of Wound Infection in Complicated Appendicitis Completed NCT01659983 Phase 3
29 Diagnosis of Acute Appendicitis: Low-dose Computed Tomography (CT) Versus Standard-dose CT Completed NCT00913380 Phase 3
30 Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures Completed NCT01524081 Phase 3 Metronidazole, Cefuroxime;Amoxicillin (+ clavulanic acid) and Fluconazole;Placebo;Placebo
31 Laparoscopic Appendectomy for Chronic Right Lower Abdominal Pain Completed NCT00413855 Phase 3
32 Single Incision Versus Conventional Laparoscopic Appendectomy Completed NCT01515293 Phase 3
33 A Randomised Controlled Trial on LESS Versus Conventional Laparoscopic Appendicectomy. Completed NCT01203566 Phase 3
34 Efficacy and Safety Study of Eravacycline Compared With Meropenem in Complicated Intra-abdominal Infections Completed NCT02784704 Phase 3 Eravacycline;Meropenem;Placebo
35 Doripenem in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00229060 Phase 3 doripenem
36 Doripenem in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00210938 Phase 3 Doripenem
37 Sublingual Analgesia for Acute Abdominal Pain in Children Completed NCT02465255 Phase 3 Ketorolac;Tramadol;Acetaminophen
38 Safety and Efficacy of Albiglutide + Insulin Glargine Versus Insulin Lispro + Insulin Glargine Subjects With Type 2 Diabetes Mellitus Completed NCT02229227 Phase 3 Albiglutide;Insulin Glargine and Insulin Lispro
39 The Value of Post-operative Antibiotic Therapy After Laparoscopic Appendectomy for Complicated Acute Appendicitis (Other Than for Generalized Peritonitis) Not yet recruiting NCT03688295 Phase 3 Antibiotics
40 A Safety and Tolerability Study of Doripenem Compared With Meropenem in Children Hospitalized With Complicated Intra-abdominal Infections Terminated NCT01110382 Phase 3 Doripenem;Meropenem placebo;Meropenem;Doripenem placebo;Amoxicillin/clavulanate potassium
41 Nebulized Analgesia for Laparoscopic Appendectomy Trial Unknown status NCT02624089 Phase 1, Phase 2 Ropivacaine;Normal saline
42 Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis Completed NCT02664220 Phase 2 Povidone-iodine irrigation
43 Study of Conservative Versus Surgical Treatment of Appendicitis Completed NCT00469430 Phase 2 cefotaxim and metronidazol
44 The Safety and Pharmacokinetics of Intraperitoneal Administration in Patients Undergoing Appendectomy for Uncomplicated Appendicitis Completed NCT03046758 Phase 2 A combination of fosfomycin, metronidazole and GM-CSF i.p.
45 Intraperitoneal Administration of Fosfomycin, Metronidazole and Molgramostim Versus Intravenous Antibiotics for Perforated Appendicitis Completed NCT03435900 Phase 2 Combination of fosfomycin, metronidazole and rhGM-CSF (administered together intraperitoneally) and three days of antibiotics p.o.;Standard antibiotics intravenously
46 Preoperative Methylprednisolone to Patients Suspected of Appendicitis Undergoing Laparoscopy Completed NCT02711449 Phase 2 Methylprednisolone;0.9% Saline
47 Dexamethasone Preoperative for Patients Undergoing Laparoscopy for Suspected Appendicitis Completed NCT02415335 Phase 2 dexamethasone phosphate;Isotonic NaCl
48 Laparoscopic Management of Periappendicular Abscess Completed NCT01283815 Phase 2
49 Conservative Versus Operative ManageMent of Acute Uncomplicated Appendicitis Recruiting NCT02916134 Phase 2 Antibiotic treatment
50 The Role of Contrast Enhanced Ultrasound in Appendicitis Recruiting NCT03687502 Phase 2 Sulfur hexafluoride lipid-type A microspheres

Search NIH Clinical Center for Appendicitis

Cochrane evidence based reviews: appendicitis

Sources

Genetic Tests for Appendicitis

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Anatomical Context for Appendicitis

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MalaCards organs/tissues related to Appendicitis:

41
Appendix, Kidney, Testes, Colon, Neutrophil, Liver, Bone
Sources

Publications for Appendicitis

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Articles related to Appendicitis:

(show top 50) (show all 2357)
# Title Authors Year
1
Pediatric subhepatic appendicitis with elevated lipase. ( 30361147 )
2019
2
Withholding Urinary Catheters in Children Receiving Patient-Controlled Analgesia for Appendicitis. ( 30502234 )
2019
3
A case of acute appendicitis due to intestinal schistosomiasis. ( 30555690 )
2019
4
Parasitic Appendicitis: A Novel Laparoscopic Approach for the Prevention of Peritoneal Contamination. ( 29977414 )
2018
5
The RIPASA score for the diagnosis of acute appendicitis: A comparison with the modified Alvarado score. ( 29426650 )
2018
6
Acute appendicitis in leukaemia patients undergoing haematopoietic stem cell transplantation during the neutropaenic phase: a case series from a single BMT centre in China. ( 29410536 )
2018
7
Evaluation of Diagnostic Scores for Acute Appendicitis. ( 29394968 )
2018
8
Suspicion of appendicitis in pregnant women: emergency evaluation by sonography and low-dose CT with oral contrast. ( 29948087 )
2018
9
Burkitt's lymphoma presenting as acute appendicitis: a case report. ( 29942479 )
2018
10
Pus Samples in Complicated Appendicitis: An Important Investigation or a Waste of Resources: A Prospective Cohort Study. ( 29973114 )
2018
11
Endoloop versus endostapler: what is the best option for appendiceal stump closure in children with complicated appendicitis? Results of a multicentric international survey. ( 29404732 )
2018
12
Don't be short-sighted: cervical incompetence in a pregnant patient with acute appendicitis. ( 29414522 )
2018
13
Ileal Cystic Lymphangioma presenting with Acute Appendicitis. ( 29386763 )
2018
14
Laparoscopic appendectomy for the treatment of acute appendicitis: a single center experience. ( 29393074 )
2018
15
Acute Appendicitis as an Unexpected Cause of Inverted Takotsubo Cardiomyopathy. ( 29937647 )
2018
16
Questionable Assumptions Provided in Nonoperative Treatment of Appendicitis Survey. ( 29971340 )
2018
17
Acute appendicitis complicated with necrotizing fasciitis in a patient with adult-onset Still's disease: A case report. ( 29384877 )
2018
18
Efficacy of Strain Elastography in Diagnosis and Staging of Acute Appendicitis in Pediatric Patients. ( 29428963 )
2018
19
Effect of Delay to Operation on Outcomes in Patients with Acute Appendicitis: a Systematic Review and Meta-analysis. ( 29980978 )
2018
20
Non-operative treatment of appendicitis: public perception and decision-making. ( 29423825 )
2018
21
Different manifestation of a familiar diagnosis: From anuria to acute appendicitis. ( 29510913 )
2018
22
An Ulcerated Ileal Gastrointestinal Stromal Tumor Disguised as Acute Appendicitis. ( 29971179 )
2018
23
Clinical prediction score for superficial surgical site infection after appendectomy in adults with complicated appendicitis. ( 29946346 )
2018
24
An Unusual Case of Inflammatory Myofibroblastic Tumor of the Appendix Masquerading as Acute Appendicitis. ( 29896334 )
2018
25
Atypical presentation of type B aortic dissection mimicking appendicitis managed medically. ( 29960968 )
2018
26
Accuracy of ultrasound exam performed by emergency medicine versus radiology residents in the diagnosis of acute appendicitis. ( 29438133 )
2018
27
Gangrenous giant Meckel's diverticulitis masquerading acute appendicitis: a surgical conundrum. ( 29695030 )
2018
28
Is there a role for routine colonoscopy in the follow-up after acute appendicitis? ( 29979091 )
2018
29
Ultrasound and computed tomography of sacculitis and appendicitis in a rabbit. ( 29393561 )
2018
30
Appendicitis in the HIV Era: a South African perspective. ( 29973748 )
2018
31
Questionable Assumptions Provided in Nonoperative Treatment of Appendicitis Survey-Reply. ( 29971345 )
2018
32
Surgeon-Performed Ultrasound in Diagnosing Acute Cholecystitis and Appendicitis. ( 29882098 )
2018
33
Economic Analysis of Diagnostic Imaging in Pediatric Patients with Suspected Appendicitis. ( 29427374 )
2018
34
Diagnostic accuracy of surgeon performed ultrasound (SPU) for appendicitis in children. ( 29980345 )
2018
35
Acute enterocolitis causing an appendicitis like symdrome. ( 29932094 )
2018
36
Appendiceal outer diameter as an indicator of acute appendicitis in young children. ( 29428695 )
2018
37
A case of De Garengeot's hernia with acute appendicitis and literature review. ( 29960210 )
2018
38
Ulysses Syndrome: The Modern-day Odyssey of Pediatric Patients With Uncomplicated Acute Appendicitis. ( 29401107 )
2018
39
Analysis of Appendiceal Neoplasms on 3544 Appendectomy Specimens for Acute Appendicitis: Retrospective Cohort Study of a Single Institution. ( 29947345 )
2018
40
Appendicitis Grade, Operative Duration, and Hospital Cost. ( 29391281 )
2018
41
Acute single appendicitis in a female with a duplicated appendix. ( 29942480 )
2018
42
Drain Failure in Intra-Abdominal Abscesses Associated with Appendicitis. ( 29431586 )
2018
43
Acute eosinophilic appendicitis: a radiologic-pathologic correlation. ( 29960267 )
2018
44
Acute Appendicitis as the Initial Clinical Presentation of Primary HIV-1 Infection. ( 29423422 )
2018
45
Population-based cohort study on the epidemiology of acute appendicitis in children in Sweden in 1987-2013. ( 29951638 )
2018
46
Imaging Approach to the Diagnosis of Acute Appendicitis in a Group of Teaching Hospitals With 24/7 In-house Availability of Ultrasound Technologist: Effect of Timing of Request on Imaging Modality. ( 29958834 )
2018
47
Sessile serrated adenoma/polyp leading to acute appendicitis with multiple pyogenic liver abscesses: A case report. ( 29216529 )
2018
48
Suspicion of acute appendicitis in adults. The value of ultrasound in our hospital. ( 30290969 )
2018
49
The non-visualized appendix and secondary signs on ultrasound for pediatric appendicitis in the community hospital setting. ( 30293146 )
2018
50
Perforated vs nonperforated acute appendicitis: evaluation of short-term surgical outcomes in an elderly population. ( 30306768 )
2018
Sources

Variations for Appendicitis

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Expression for Appendicitis

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Search GEO for disease gene expression data for Appendicitis.
Sources

Pathways for Appendicitis

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Pathways related to Appendicitis according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.81 CD19 CRP CXCL8 HMGB1 IL10 IL1B
2
Cytokine Signaling in Immune system 66
Show member pathways
 13.37 CXCL8 IL10 IL1B IL6 LBP MMP9
3
PAK Pathway 64
Show member pathways
 13.27 CXCL8 IL10 IL1B IL6 TIMP1 TNF
4
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 13.03 CXCL8 IL10 IL1B IL6 LBP TNF
5
Allograft rejection 1 37
Show member pathways
 12.86 CXCL8 IL10 IL1B IL6 TNF
6
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.78 CXCL8 HMGB1 IL1B IL6 TNF
7
NF-kappaB Signaling 4
12.61 CD19 IL10 IL1B MPO TNF
8
Immune response IL-23 signaling pathway 22
Show member pathways
 12.61 IL10 IL1B IL6 MPO TIMP1 TNF
9
Th17 cell differentiation 37
Show member pathways
 12.57 IL10 IL1B IL6 TNF
10
T cell receptor signaling pathway 37
Show member pathways
 12.43 IL10 IL1B IL6 TNF
11
IL-17 Family Signaling Pathways 65
Show member pathways
 12.37 CXCL8 IL1B IL6 MMP9 TNF
12
Toll Comparative Pathway 64
Show member pathways
 12.36 CXCL8 IL1B IL6 LBP TNF
13
Selenium Micronutrient Network 1
Show member pathways
 12.32 ALB CRP IL1B IL6 MPO TNF
14
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.29 CXCL8 IL10 IL1B IL6 TIMP1 TNF
15
Transcriptional misregulation in cancer 37
12.28 CXCL8 IL6 MMP9 MPO
16
Tuberculosis 37
12.27 IL10 IL1B IL6 LBP TNF
17
IL-1 Family Signaling Pathways 65
Show member pathways
 12.25 CXCL8 IL1B IL6 TNF
18
C-type lectin receptor signaling pathway 37
Show member pathways
 12.24 IL10 IL1B IL6 TNF
19
Bacterial infections in CF airways 22
Show member pathways
 12.23 CXCL8 IL1B IL6 LBP TNF
20
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.22 CXCL8 IL10 IL1B IL6 TNF
21
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.11 CXCL8 IL10 IL1B IL6 TIMP1
22
Th1 Differentiation Pathway 65
Show member pathways
 12.11 IL10 IL1B IL6 TNF
23
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 12.08 HMGB1 IL1B IL6 MMP9 TNF
24
Spinal Cord Injury 1
12.05 CXCL8 IL1B IL6 MMP9 TNF
25
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
12.03 CD19 IL10 IL6 MPO TNF
26
TNF signaling pathway 37
12.02 IL1B IL6 MMP9 TNF
27
AGE-RAGE signaling pathway in diabetic complications 37
11.97 CXCL8 IL1B IL6 TNF
28
Matrix Metalloproteinases 1
Show member pathways
 11.97 MMP8 MMP9 TIMP1 TNF
29
Hematopoietic cell lineage 37
11.95 CD19 IL1B IL6 TNF
30
Senescence and Autophagy in Cancer 1
11.93 CXCL8 IL1B IL6
31
NF-kappa B signaling pathway 37
11.93 CXCL8 IL1B LBP TNF
32
Amoebiasis 37
11.92 CXCL8 IL10 IL1B IL6 TNF
33
Rheumatoid arthritis 37
11.91 CXCL8 IL1B IL6 TNF
34
HIF-1 signaling pathway 37
11.9 ENO2 IL6 TIMP1
35
IL6-mediated signaling events 1
Show member pathways
 11.88 CRP IL6 LBP TIMP1
36
Salmonella infection (KEGG) 37
11.88 CXCL8 IL1B IL6 LBP
37
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.87 CXCL8 IL6 LBP
38
Innate Lymphoid Cell Differentiation Pathways 65
11.8 IL10 IL1B TNF
39
Pertussis 37
11.77 CXCL8 IL10 IL1B IL6 TNF
40
Dendritic Cells Developmental Lineage Pathway 65
11.74 CD19 IL10 IL1B IL6 TNF
41
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.71 IL10 IL1B IL6 MMP9 TNF
42
LPA receptor mediated events 1
11.7 CXCL8 IL6 MMP9
43
Cell adhesion_ECM remodeling 22
11.68 CXCL8 MMP9 TIMP1
44
Legionellosis 37
11.63 CXCL8 IL1B IL6 TNF
45
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.6 CXCL8 IL1B IL6 MMP9 TNF
46
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.53 IL1B IL6 TNF
47
Lung fibrosis 1
11.43 CXCL8 IL1B IL6 MMP9 TIMP1 TNF
48
Malaria 37
11.41 CXCL8 IL10 IL1B IL6 TNF
49
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.4 CXCL8 IL6 MMP9
50
African trypanosomiasis 37
11.4 IL10 IL1B IL6 TNF
Sources

GO Terms for Appendicitis

About this section

Cellular components related to Appendicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.81 ALB CD19 ENO2 IL1B LBP LRG1
2 extracellular region GO:0005576 9.8 ALB CRP CXCL8 HMGB1 IL10 IL1B
3 extracellular space GO:0005615 9.5 ALB CRP CXCL8 ENO2 HMGB1 IL10
4 tertiary granule lumen GO:1904724 9.43 LRG1 MMP8 MMP9

Biological processes related to Appendicitis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.98 CXCL8 HMGB1 IL10 IL1B IL6 TIMP1
2 positive regulation of protein phosphorylation GO:0001934 9.96 HMGB1 IL1B MMP9 TNF
3 response to lipopolysaccharide GO:0032496 9.95 IL10 IL1B LBP MPO
4 inflammatory response GO:0006954 9.95 CRP CXCL8 HMGB1 IL10 IL1B IL6
5 response to organic substance GO:0010033 9.89 IL10 TIMP1 TNF
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.88 IL10 IL1B IL6 TNF
7 extracellular matrix disassembly GO:0022617 9.85 MMP8 MMP9 TIMP1
8 defense response to Gram-positive bacterium GO:0050830 9.85 CRP IL6 LBP TNF
9 cellular response to lipopolysaccharide GO:0071222 9.85 CXCL8 IL10 IL1B IL6 LBP TNF
10 positive regulation of tumor necrosis factor production GO:0032760 9.84 HMGB1 LBP MMP8
11 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.83 IL10 MMP9 TNF
12 positive regulation of JNK cascade GO:0046330 9.83 HMGB1 IL1B MMP8 TNF
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 IL1B MMP8 TNF
14 acute-phase response GO:0006953 9.79 CRP IL6 LBP
15 lipopolysaccharide-mediated signaling pathway GO:0031663 9.78 IL1B LBP TNF
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.78 HMGB1 IL1B MMP8 TNF
17 positive regulation of DNA binding GO:0043388 9.77 HMGB1 MMP8 MMP9
18 positive regulation of interleukin-8 production GO:0032757 9.76 IL1B LBP TNF
19 negative regulation of neurogenesis GO:0050768 9.74 IL1B IL6 TNF
20 positive regulation of neutrophil chemotaxis GO:0090023 9.73 CXCL8 IL1B LBP
21 response to glucocorticoid GO:0051384 9.72 HMGB1 IL10 IL1B IL6 TNF
22 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IL1B TNF
23 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 IL10
24 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.71 HMGB1 IL1B
25 positive regulation of chemokine production GO:0032722 9.71 IL6 LBP TNF
26 macrophage activation involved in immune response GO:0002281 9.7 HMGB1 LBP
27 positive regulation of toll-like receptor 4 signaling pathway GO:0034145 9.7 HMGB1 LBP
28 opsonization GO:0008228 9.7 CRP LBP
29 endothelial cell apoptotic process GO:0072577 9.69 IL10 TNF
30 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.69 IL10 TIMP1
31 positive regulation of chemokine biosynthetic process GO:0045080 9.69 IL1B TNF
32 positive regulation of glial cell proliferation GO:0060252 9.69 IL1B IL6 TNF
33 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
34 negative regulation of cytokine secretion involved in immune response GO:0002740 9.67 IL10 TNF
35 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.67 IL10 IL1B TNF
36 positive regulation of fever generation GO:0031622 9.66 IL1B TNF
37 regulation of neuroinflammatory response GO:0150077 9.66 MMP8 MMP9
38 chronic inflammatory response to antigenic stimulus GO:0002439 9.64 IL1B TNF
39 sequestering of triglyceride GO:0030730 9.64 IL1B TNF
40 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.63 IL1B TNF
41 negative regulation of lipid storage GO:0010888 9.63 CRP IL6 TNF
42 receptor biosynthetic process GO:0032800 9.62 IL10 TNF
43 regulation of microglial cell activation GO:1903978 9.62 MMP8 TNF
44 negative regulation of growth of symbiont in host GO:0044130 9.56 IL10 LBP MPO TNF
45 cytokine-mediated signaling pathway GO:0019221 9.56 CXCL8 IL10 IL1B IL6 LBP MMP9
46 positive regulation of neuroinflammatory response GO:0150078 9.46 IL1B IL6 MMP8 TNF
47 positive regulation of interleukin-6 production GO:0032755 9.1 HMGB1 IL1B IL6 LBP MMP8 TNF
48 immune response GO:0006955 10.08 CXCL8 IL10 IL1B IL6 TNF
49 neutrophil degranulation GO:0043312 10.08 HMGB1 LRG1 MMP8 MMP9 MPO
50 negative regulation of apoptotic process GO:0043066 10.08 ALB IL10 IL6 MMP9 MPO TIMP1

Molecular functions related to Appendicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.8 ALB CD19 CRP CXCL8 ENO2 HMGB1
2 cytokine activity GO:0005125 9.17 CXCL8 HMGB1 IL10 IL1B IL6 TIMP1
Sources

Sources for Appendicitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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