MCID: APP010
MIFTS: 43

Appendix Cancer

Categories: Cancer diseases, Gastrointestinal diseases
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Aliases & Classifications for Appendix Cancer

MalaCards integrated aliases for Appendix Cancer:

Name: Appendix Cancer 11 14 75
Appendiceal Neoplasms 43 71
Malignant Neoplasm of Appendix Vermiformis 11
Malignant Tumor of the Appendix 11
Malignant Neoplasm of Appendix 71
Malignant Tumor of Appendix 11
Carcinoma of the Appendix 71
Cancer of the Appendix 11

Classifications:



External Ids:

Disease Ontology 11 DOID:11239
ICD9CM 34 153.5
MeSH 43 D001063
NCIt 49 C9333
SNOMED-CT 68 93679002
ICD10 31 C18.1
UMLS 71 C0003614 C0496779 C0728951

Summaries for Appendix Cancer

Disease Ontology: 11 A intestinal cancer that is located in the appendix.

MalaCards based summary: Appendix Cancer, also known as appendiceal neoplasms, is related to appendiceal neoplasm and neuroendocrine tumor. An important gene associated with Appendix Cancer is KRT7 (Keratin 7), and among its related pathways/superpathways are Development EGFR signaling pathway and Breast cancer pathway. The drugs Levoleucovorin and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include appendix, colon and small intestine, and related phenotypes are Reduced mammosphere formation and neoplasm

Wikipedia: 75 Appendix cancer are very rare cancers of the vermiform... more...

Related Diseases for Appendix Cancer

Diseases related to Appendix Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 474)
# Related Disease Score Top Affiliating Genes
1 appendiceal neoplasm 31.1 SATB2 PEX19 KRT7 KRAS HRAS GNAS
2 neuroendocrine tumor 30.2 PAX8 KRT20 CDX2
3 appendix adenocarcinoma 30.1 TP53 SMAD4 SATB2 PEX19 KRT7 KRT20
4 intestinal obstruction 29.9 KRT7 KRT20 CEACAM5 CDX2
5 pseudomyxoma peritonei 29.8 TP53 REG4 MUC6 MUC5AC MUC1 KRT7
6 neuroendocrine carcinoma 29.8 MUC1 KRT7 KRT20
7 diffuse gastric cancer 29.7 TP53 SMAD4 KRAS
8 krukenberg carcinoma 29.4 SATB2 PAX8 KRT7 KRT20 CEACAM5 CDX2
9 adenocarcinoma 28.9 TP53 SMAD4 MUC5AC MUC1 KRT7 KRT20
10 lynch syndrome 28.8 TP53 SMAD4 KRT7 KRAS HRAS GNAS
11 cystadenocarcinoma 28.7 TP53 PAX8 MUC5AC MUC1 KRT7 KRAS
12 mucinous cystadenocarcinoma 28.6 SMAD4 MUC1 KRT7 KRT20 KRAS HRAS
13 colonic benign neoplasm 28.6 TP53 SMAD4 MUC5AC KRT7 KRT20 KRAS
14 villous adenoma 28.6 TP53 SMAD4 MUC6 MUC5AC KRT7 KRAS
15 ovary adenocarcinoma 28.5 TP53 PAX8 MUC1 KRT7 KRAS HRAS
16 cystadenoma 28.5 REG4 MUC6 MUC5AC MUC1 KRT7 KRT20
17 signet ring cell adenocarcinoma 28.3 TP53 MUC6 MUC5AC MUC1 KRT7 KRT20
18 ovarian cancer 28.2 TP53 SMAD4 MUC5AC MUC1 KRT7 KRT20
19 adenoma 28.1 TP53 SMAD4 MUC6 MUC5AC MUC1 KRT7
20 ovarian cystadenocarcinoma 28.0 TP53 SMAD4 PAX8 MUC6 MUC5AC MUC1
21 mucinous adenocarcinoma 27.7 TP53 SMAD4 PAX8 MUC6 MUC5AC MUC1
22 colorectal cancer 26.9 TP53 SMAD4 REG4 MUC6 MUC5AC MUC1
23 appendix carcinoid tumor 11.1
24 bladder signet ring cell adenocarcinoma 10.4 KRT7 CDX2
25 spiradenoma 10.4 KRT7 CEACAM5
26 ovary neuroendocrine neoplasm 10.4 KRT7 CDX2
27 leukoplakia of penis 10.4 KRT7 CEACAM5
28 anal canal paget's disease 10.4 KRT7 CDX2
29 adenosquamous colon carcinoma 10.4 KRT7 CDX2
30 trachea carcinoma 10.4 KRT7 CEACAM5
31 laryngeal mucoepidermoid carcinoma 10.4 CEACAM5 CDX2
32 aggressive digital papillary adenocarcinoma 10.4 KRT7 CEACAM5
33 cutaneous mucoepidermoid carcinoma 10.4 KRT7 CEACAM5
34 malignant epithelial mesothelioma 10.4 KRT7 CEACAM5
35 jejunal adenocarcinoma 10.4 KRT7 CDX2
36 gastric signet ring cell adenocarcinoma 10.4 KRT7 CDX2
37 rectum neuroendocrine neoplasm 10.4 KRT7 CDX2
38 adenosquamous bile duct carcinoma 10.4 KRT7 CEACAM5
39 ureter squamous cell carcinoma 10.4 KRT7 CEACAM5
40 colloid carcinoma of the pancreas 10.3 MUC5AC CDX2
41 apocrine adenoma 10.3 KRT7 CEACAM5
42 vulval paget's disease 10.3 KRT7 CEACAM5
43 bile duct signet ring cell carcinoma 10.3 KRT7 KRT20
44 signet ring basal cell carcinoma 10.3 KRAS CEACAM5
45 malignant biphasic mesothelioma 10.3 KRT7 CEACAM5
46 endometrial mucinous adenocarcinoma 10.3 KRAS GNAS
47 adenoid basal cell carcinoma 10.3 KRT7 CEACAM5
48 immature teratoma of ovary 10.3 KRAS CEACAM5
49 nodular hidradenoma 10.3 KRT7 CEACAM5
50 sublingual gland cancer 10.3 KRT7 CDX2

Comorbidity relations with Appendix Cancer via Phenotypic Disease Network (PDN):


Cecal Benign Neoplasm

Graphical network of the top 20 diseases related to Appendix Cancer:



Diseases related to Appendix Cancer

Symptoms & Phenotypes for Appendix Cancer

GenomeRNAi Phenotypes related to Appendix Cancer according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 GNAS HRAS KRAS KRT7 MUC5AC PAX8

MGI Mouse Phenotypes related to Appendix Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 10.02 CDX2 CEACAM5 GNAS HRAS KRAS MUC1
2 normal MP:0002873 9.92 CDX2 GNAS HRAS KRAS MUC1 PAX8
3 endocrine/exocrine gland MP:0005379 9.85 CDX2 CEACAM5 GNAS HRAS KRAS MUC1
4 limbs/digits/tail MP:0005371 9.8 CDX2 GNAS KRAS PAX8 SATB2 SMAD4
5 digestive/alimentary MP:0005381 9.7 CDX2 CEACAM5 GNAS HRAS KRAS MUC1
6 craniofacial MP:0005382 9.17 GNAS HRAS KRAS PAX8 SATB2 SMAD4

Drugs & Therapeutics for Appendix Cancer

Drugs for Appendix Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 89)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levoleucovorin Approved, Experimental, Investigational Phase 2 68538-85-2, 58-05-9, 73951-54-9 149436 6006
2
Fluorouracil Approved Phase 2 51-21-8 3385
3
Durvalumab Approved, Investigational Phase 1, Phase 2 1428935-60-7
4
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
5
Thalidomide Approved, Investigational, Withdrawn Phase 2 50-35-1 5426
6
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
7
Mitomycin Approved Phase 2 50-07-7 5746
8
Floxuridine Approved Phase 2 50-91-9 5790
9
Melphalan Approved Phase 2 148-82-3 4053 460612
10
Cetuximab Approved Phase 1, Phase 2 205923-56-4
11
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
12
Amoxicillin Approved, Vet_approved Phase 2 26787-78-0 33613
13
Carbamide peroxide Approved Phase 2 124-43-6
14
Dexlansoprazole Approved, Investigational Phase 2 138530-94-6 9578005
15
Lansoprazole Approved, Investigational Phase 2 103577-45-3 3883
16
Clarithromycin Approved Phase 2 81103-11-9 84029
17
Nintedanib Approved Phase 2 656247-17-5 135423438 9809715
18
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
19
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 43805 11947679 6857599
20
Nivolumab Approved Phase 2 946414-94-4
21
Ipilimumab Approved Phase 2 477202-00-9
22
Palonosetron Approved, Investigational Phase 2 119904-90-4, 135729-56-5 148211 6337614
23
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
24
Exatecan Investigational Phase 1, Phase 2 171335-80-1 18546929 151115
25 Hormones Phase 2
26 Calcium, Dietary Phase 2
27 Angiogenesis Inhibitors Phase 2
28 Albumin-Bound Paclitaxel Phase 2
29 Vitamins Phase 2
30 Folate Phase 2
31 Alkylating Agents Phase 2
32 Vitamin B9 Phase 2
33 Trace Elements Phase 2
34 Vitamin B Complex Phase 2
35 Antidotes Phase 2
36 Micronutrients Phase 2
37 Protective Agents Phase 2
38 Antimitotic Agents Phase 2
39 Tubulin Modulators Phase 2
40 Antineoplastic Agents, Alkylating Phase 2
41 Immunosuppressive Agents Phase 2
42 Immunologic Factors Phase 2
43 Antimetabolites Phase 2
44 Anti-Bacterial Agents Phase 2
45 Antibiotics, Antitubercular Phase 2
46 Anti-Ulcer Agents Phase 2
47 Anti-Infective Agents Phase 2
48 Antacids Phase 2
49 Proton Pump Inhibitors Phase 2
50 Cytochrome P-450 Enzyme Inhibitors Phase 2

Interventional clinical trials:

(show all 50)
# Name Status NCT ID Phase Drugs
1 Randomized Therapeutic Study Comparing Tumor Resection Followed Immediately by Intraperitoneal Chemotherapy and Systemic Chemotherapy VS Systemic Chemotherapy Alone for the Treatment of Colorectal Cancer Metastatic to the Peritoneum Unknown status NCT00006112 Phase 2 chemotherapy;fluorouracil;leucovorin calcium;mitomycin C
2 Repetitive Electrostatic Pressurised Intraperitoneal Aerosol Chemotherapy With Oxaliplatin (ePIPAC-OX) as a Palliative Monotherapy for Isolated Unresectable Colorectal Peritoneal Metastases: Protocol of a Multicentre, Open-label, Single-arm, Phase II Study (CRC-PIPAC) Completed NCT03246321 Phase 2
3 Single Arm Study Treating Patients of Peritoneal Surface Malignancy (Colorectal, Appendical, Pseudomyxoma, Gastric) With Cytoreductive Surgery and Hyperthermic Intraperitoneal Mitomycin-C Completed NCT02040142 Phase 2 Mitomycin C
4 A Phase 1/2 Dose Escalation Study With Expansion Cohorts to Investigate the Safety, Biologic and Anti-tumor Activity of ONCOS-102 in Combination With Durvalumab in Subjects With Advanced Peritoneal Malignancies Completed NCT02963831 Phase 1, Phase 2 Durvalumab
5 Phase II Trial of Adjuvant Thalidomide Following Cytoreductive Surgery and Intraperitoneal Hyperthermic Chemotherapy for Peritoneal Carcinomatosis or Adenomucinosis From Colorectal/Appendiceal Cancer Completed NCT00310076 Phase 2 thalidomide
6 A Multi-Center, Open-Label, Randomized Phase II Trial to Evaluate Hematologic Toxicities After HIPEC With Oxaliplatin or Mitomycin C in Patients With Appendiceal Tumors Completed NCT01580410 Phase 2 mitomycin C;oxaliplatin;hyperthermic intraperitoneal chemotherapy
7 A Phase 1/2 Study of CBX-12 in Subjects With Advanced or Metastatic Refractory Solid Tumors Recruiting NCT04902872 Phase 1, Phase 2 CBX-12
8 Randomized Controlled Trial of Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes Recruiting NCT04907643 Phase 2
9 ICARuS (Intraperitoneal Chemotherapy After cytoReductive Surgery): A Multi-center, Randomized Phase II Trial of Early Post-operative Intraperitoneal Chemotherapy (EPIC) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) After Optimal Cytoreductive Surgery (CRS) for Neoplasms of the Appendix, Colon or Rectum With Isolated Peritoneal Metastasis Recruiting NCT01815359 Phase 2 HIPEC with Mitomycin-C;EPIC with FUDR and Leucovorin
10 Phase II Study of Intravenous and Intraperitoneal Paclitaxel and Oral Nilotinib for Peritoneal Carcinomatosis From Colorectal, Appendiceal, Ovarian, or Other Gynecologic Primary Cancer Recruiting NCT05185947 Phase 2 Paclitaxel;Nilotinib
11 Phase II Single-Blind Randomized Trial Comparing Morbidity of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) Using Mitomycin-C Versus Melphalan for Colorectal Peritoneal Carcinomatosis Recruiting NCT03073694 Phase 2 Mitomycin c;Melphalan
12 A Phase Ib/II Trial of JAB-21822 in Combination With Cetuximab in Patients With Advanced Colorectal Cancer, Small Intestine Cancer and Appendiceal Cancer With KRAS G12C Mutation Recruiting NCT05194995 Phase 1, Phase 2 JAB-21822;Cetuximab
13 Surufatinib and Sintilimab in Combination With Capecitabine in Patients With Previously Treated Metastatic Adenocarcinoma of Small Intestine or Appendix Carcinoma : a Single-arm, a Single-center , Phase 2 Trial Recruiting NCT05472948 Phase 2 Surufatinib
14 Clinical Trial to Define the Effect of Perioperative H. Pylori Eradication With Antibiotic Treatment on Long Term Outcomes of Patients With Pseudomyxoma Peritonei of Appendiceal Origin Undergoing Cytoreductive Surgery/Hyperthermic Intraperitoneal Chemotherapy Active, not recruiting NCT02387203 Phase 2 PrevPac (Prevacid, Amoxicillin, Clarithromycin)
15 LCI-GI-APX-NIN-001: Nintedanib in Metastatic Appendiceal Carcinoma Terminated NCT03287947 Phase 2 nintedanib
16 A Phase II Study of Nivolumab and Ipilimumab in Mucinous Colorectal and Appendiceal Tumors Terminated NCT03693846 Phase 2 Nivolumab;Ipilimumab
17 Treatment of a Cancerous Disease of the Peritoneum With Complete Cytoreductive Surgery With Intraperitoneal Chemohyperthermia Using Oxaliplatin Plus Irinotecan Terminated NCT00180960 Phase 2 Oxaliplatin and irinotecan
18 A Pilot Phase II, Randomized, Double Blind Trial of Palonosetron Versus Placebo to Prevent Radiation Therapy Induced Nausea and Vomiting Terminated NCT00903396 Phase 2 palonosetron hydrochloride
19 Phase I Trial of Intraperitoneal Oxaliplatin in Combination With Intravenous FOLFIRI (5-fluorouracil, Leucovorin and Irinotecan) for Peritoneal Carcinomatosis From Colorectal and Appendiceal Cancer Completed NCT02833753 Phase 1 Oxaliplatin
20 A Phase I Evaluation of Intraperitoneal Hyperthermic Chemoperfusion With Oxaliplatin for Peritoneal Surface Disemmination of Appendiceal and Colorectal Cancer Completed NCT00458809 Phase 1 oxaliplatin
21 A Phase I Clinical and Biological Evaluation of Combined EGFR Blockade With Erlotinib and Cetuximab in Patients With Advanced Cancer Completed NCT00397384 Phase 1 cetuximab;erlotinib hydrochloride
22 A Pharmacogenetic-Based Phase I Trial of Irinotecan, 5-Fluorouracil, and Leucovorin (FOLFIRI) in Patients With Advanced Gastrointestinal Cancer Completed NCT00654160 Phase 1 fluorouracil;irinotecan hydrochloride;leucovorin calcium
23 Pilot Study of Oxaliplatin in Combination With Capecitabine in Adult Cancer Patients Completed NCT00019773 Phase 1 capecitabine;oxaliplatin
24 A Phase I Study of UCN-01 in Combination With Irinotecan in Resistant Solid Tumor Malignancies (Part I) and in Triple Negative (ER-Negative, PgR-Negative, HER-2 Not-Amplified) Recurrent Breast Cancers (Part II) Completed NCT00031681 Phase 1 7-hydroxystaurosporine;irinotecan hydrochloride
25 A Phase I Trial of Herceptin and Interleukin-12 Completed NCT00004074 Phase 1
26 Safety and Efficacy of Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC) in Ovarian, Uterine, Appendiceal, Colorectal, and Gastric Cancer Patients With Peritoneal Carcinomatosis (PC) Recruiting NCT04329494 Phase 1 Cisplatin;Doxorubicin;Fluorouracil;Irinotecan;Leucovorin;Mitomycin;Oxaliplatin
27 Individualized Response Assessment to Heated Intraperitoneal Chemotherapy (HIPEC) for the Treatment of Peritoneal Carcinomatosis From Ovarian, Colorectal, Appendiceal, or Peritoneal Mesothelioma Histologies Recruiting NCT04847063 Phase 1 Mitomycin C;Cisplatin;Doxorubicin;Oxaliplatin;5-Fluorouracil;Sodium Thiosulfate
28 Intraperitoneal Aerosolized Nanoliposomal Irinotecan (Nal-IRI) in Peritoneal Carcinomatosis From Gastrointestinal Cancer: a Phase I Study Not yet recruiting NCT05277766 Phase 1 PIPAC with Nal-IRI
29 Phase I Trial of Intraperitoneal Oxaliplatin in Combination With Intravenous mFOLFIRI for Peritoneal Carcinomatosis From Colorectal and Appendiceal Cancer Terminated NCT04158349 Phase 1 Oxaliplatin;mFOLFIRI
30 Multicenter, International Online Documentation of Indications and Results of Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC Und PITAC) for Treating Malignant Peritoneal and Pleural Diseases Unknown status NCT03210298
31 Selective Rather Than Routine Histopathological Examination Following Appendectomy and Cholecystectomy; the FANCY Study. Unknown status NCT03510923
32 GI 1549: PROGRAMS TO SUPPORT YOU DURING CHEMOTHERAPY (PRO-YOU) A Randomized Controlled Pilot Study of Yoga Compared to an Attention Control in Patients Receiving Chemotherapy Completed NCT02489422
33 A Survey of the Knowledge, Attitudes, and Practice of Surgeons Toward Nutrition Support in HIPEC Patients Completed NCT02374411
34 Distant Metastases and Long-Term Survival After Complete Resection of Neuroendocrine Tumors of the Appendix: An International Multicenter Study Completed NCT03852693
35 Trial of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Patients With Primary Peritoneal Cancers and Secondary Peritoneal Cancers From Stomach, Colorectal, Appendiceal, and/or Gynecological Origins Completed NCT03604653 Mitomycin c;CDDP 50;CDDP 75;Doxorubicin
36 Surgical Outcome and Predictors of Overall Survival of Stage I-III Appendiceal Adenocarcinoma; a National Cancer Database Analysis Completed NCT05452382
37 HOPE Program: Quality of Life Enhancement and Survivorship Care Completed NCT01126346
38 5-hydroxymethylation Signatures in Plasma Circulating Cell-free DNA as Markers for Tumor Burden and Recurrence in Appendiceal and Colorectal Peritoneal Metastasis Recruiting NCT04157322
39 Diagnostic Value of Diffusion-weighted Magnetic Resonance Imaging for Detection of Peritoneal Recurrence in Patients With High-risk Colorectal and Appendiceal Neoplasms : a Pilot Study Recruiting NCT05623787
40 The Registry of Oncology Outcomes Associated With Testing and Treatment (ROOT) Recruiting NCT04028479 Systemic Treatment (T)
41 The PANO Trial: Perioperative Exercise and Nutrition Optimisation Prehabilitation in Cancer Patients With Peritoneal Malignancy Recruiting NCT05305820
42 A Pragmatic, Single-Arm Clinical Trial of a Novel Dose Adjustment Algorithm for Preventing Cytopenia-Related Delays During FOLFOX Chemotherapy Recruiting NCT04526886
43 A Cohort Study of the Gastrointestinal Microbiome in Appendiceal Cancer With Peritoneal Spread Recruiting NCT02599116
44 A Phase II Trial to Analyze Clinical and Pharmacological Properties for Severe Neutropenia After Cytoreductive Surgery Followed by Hyperthermic Intraperitoneal Chemotherapy Using Mitomycin-C Recruiting NCT05513183
45 Defining the Clinical Potential of Mass Response as a Biomarker for Patient Tumor Sensitivity to Drugs Recruiting NCT04985357
46 Mass Response of Malignant Fluid Cells as a Biomarker for Rapid Therapy Guidance Recruiting NCT05461430
47 The Prevalence of Appendiceal Tumours in Patients Presenting With a Periappendicular Abscess - A Nationwide Prospective Cohort Study Not yet recruiting NCT04634448
48 Justification of Incidental Appendectomy With Respect to Pathohistological Findings Not yet recruiting NCT05202600
49 Characterisation of Appendiceal Cancer by Genomic and Transcriptomic Analysis and Correlation With Clinical Outcomes Not yet recruiting NCT05364788
50 Distribution Of The Photosensitizer Motexafin Lutetium And Hypoxia In Patients With Malignancies Terminated NCT00087191 EF5;motexafin lutetium

Search NIH Clinical Center for Appendix Cancer

Cochrane evidence based reviews: appendiceal neoplasms

Genetic Tests for Appendix Cancer

Anatomical Context for Appendix Cancer

Organs/tissues related to Appendix Cancer:

FMA: Appendix
MalaCards : Appendix, Colon, Small Intestine, Breast, Liver, Lymph Node, Ovary

Publications for Appendix Cancer

Articles related to Appendix Cancer:

(show top 50) (show all 88)
# Title Authors PMID Year
1
Inherited Cancer Susceptibility Gene Sequence Variations Among Patients With Appendix Cancer. 62
36368039 2022
2
Accidental discovery of appendiceal carcinoma during gynecological surgery: A case report. 62
36158468 2022
3
Signet-ring cell carcinoma of the appendix with ganglioneuromatosis: a case report. 62
35927360 2022
4
ASO Author Reflections: If at First You Don't Succeed, Try, Try Again: Iterative CRS/HIPEC for Recurrent Mucinous Appendix Cancer. 62
35015184 2022
5
The incidence and prognostic importance of ovarian involvement in patients with peritoneal metastasis undergoing CRS-HIPEC. 62
34799231 2022
6
Establishment and validation of the survival prediction risk model for appendiceal cancer. 62
36388937 2022
7
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in appendix cancer A single-center experience. 62
36254768 2022
8
[A Case Report of Carcinoma of the Appendix Which Was Diagnosed with Ascites One Year after Appendicitis Operation]. 62
35045467 2021
9
AORTIC ARCH VARIANT AND COMMON CAROTID ARTERY AGENESIS. 62
35333461 2021
10
Repeated cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy in patients with peritoneal carcinomatosis: A retrospective cohort study. 62
34584682 2021
11
Indications and outcomes for repeat cytoreductive surgery and heated intra-peritoneal chemotherapy in peritoneal surface malignancy. 62
33915487 2021
12
Twelve-Year Single Center Experience Shows Safe Implementation of Developed Peritoneal Surface Malignancy Treatment Protocols for Gastrointestinal and Gynecological Primary Tumors. 62
34069475 2021
13
PIPAC-OX: A Phase I Study of Oxaliplatin-Based Pressurized Intraperitoneal Aerosol Chemotherapy in Patients with Peritoneal Metastases. 62
33148667 2021
14
Improved chemosensitivity following mucolytic therapy in patient-derived models of mucinous appendix cancer. 62
33164812 2021
15
Impact of signet ring cells on overall survival in peritoneal disseminated appendix cancer treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. 62
33272738 2021
16
Laparoscopic hyperthermic intraperitoneal chemotherapy for appendiceal tumors. 62
31997552 2020
17
Rational application of targeted therapeutics in mucinous colon/appendix cancers with positive predictive factors. 62
31958897 2020
18
[Appendix Cancer with Long-Term Survival after Multimodality Therapy-A Case Report]. 62
32156998 2019
19
Cancer of the appendix and nonoperative treatment of appendicitis shared decision making. 62
31432517 2019
20
AMG 510 First to Inhibit "Undruggable" KRAS. 62
31189530 2019
21
The Understated Malignancy Potential of Nonoperative Acute Appendicitis. 62
31405413 2019
22
Different distribution of mucosal-associated invariant T cells within the human cecum and colon. 62
31114440 2019
23
Preoperative Circulating Tumor DNA in Patients with Peritoneal Carcinomatosis is an Independent Predictor of Progression-Free Survival. 62
29948422 2018
24
A Multicenter Randomized Trial to Evaluate Hematologic Toxicities after Hyperthermic Intraperitoneal Chemotherapy with Oxaliplatin or Mitomycin in Patients with Appendiceal Tumors. 62
29331663 2018
25
Adenocarcinoma of the appendix occurring in a patient treated with paclitaxel for locally advanced esophageal cancer. 62
28436298 2018
26
Circulating cell-free DNA in plasma of colorectal cancer patients - A potential biomarker for tumor burden. 62
29113658 2017
27
Update on clinical trials in colorectal cancer peritoneal metastasis. 62
28142288 2017
28
The pathogenesis, diagnosis, and management of metastatic tumors to the ovary: a comprehensive review. 62
28730323 2017
29
Cancers of the appendix. Case report and literatures review. 62
28504243 2017
30
Overinterpretation is common in pathological diagnosis of appendix cancer during patient referral for oncologic care. 62
28591173 2017
31
Adverse Events Postoperatively Had No Impact on Long-Term Survival of Patients Treated with Cytoreductive Surgery with Heated Intraperitoneal Chemotherapy for Appendiceal Cancer with Peritoneal Metastases. 62
27338748 2016
32
Impact of Mucinous Histology on the Prognosis of Stage I-III Adenocarcinomas of the Appendix: a Population-Based, Propensity Score-Matched Analysis. 62
27120448 2016
33
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei and Appendix Tumours. 62
27065707 2016
34
Prognostic Molecular Subtypes of Low-Grade Cancer of the Appendix. 62
26821970 2016
35
Management of Appendix Cancer. 62
26648795 2015
36
Lymph Node Metastasis Predicts Disease Recurrence in a Single-Center Experience of 70 Stages 1-3 Appendix Cancers: A Retrospective Review. 62
25663593 2015
37
[A case of appendix cancer treated as cancer of unknown primary origin]. 62
25743145 2015
38
[No recurrent case of the combination of surgical management with chemotherapy]. 62
25731562 2014
39
Appendiceal Abscesses Reduced in Size by Drainage of Pus from the Appendiceal Orifice during Colonoscopy: A Report of Three Cases. 62
25685128 2014
40
Identifying patients at risk of emergency admission for colorectal cancer. 62
24921910 2014
41
Activity ex vivo of cytotoxic drugs in patient samples of peritoneal carcinomatosis with special focus on colorectal cancer. 62
24063788 2013
42
Iterative cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for recurrent peritoneal metastases. 62
23737041 2013
43
Systemic Chemotherapy prior to Cytoreductive Surgery and HIPEC for Carcinomatosis from Appendix Cancer: Impact on Perioperative Outcomes and Short-Term Survival. 62
22899903 2012
44
Use of FDG-PET imaging for patients with disseminated cancer of the appendix. 62
21265346 2010
45
Evaluation of the cost-effectiveness of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (peritonectomy) at the St George Hospital peritoneal surface malignancy program. 62
20040853 2010
46
[Can acute appendicitis be treated by antibiotics and in what conditions?]. 62
19846094 2009
47
[Primary malignant tumor of the appendix: clinicopathological analysis of 22 cases]. 62
19363829 2009
48
Survival and health outcomes after cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for disseminated peritoneal cancer of appendiceal origin. 62
18030535 2008
49
[A case of pseudomyxoma peritonei successfully treated with multidisciplinary treatment including modified FOLFOX6 regimen]. 62
18219894 2007
50
Definitive diagnosis of primary adenocarcinoma of the appendix by laparoscopic appendectomy. 62
17688638 2007

Variations for Appendix Cancer

Expression for Appendix Cancer

Search GEO for disease gene expression data for Appendix Cancer.

Pathways for Appendix Cancer

Pathways related to Appendix Cancer according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.28 TP53 MUC1 KRAS HRAS
2
Show member pathways
12.26 TP53 SMAD4 KRAS HRAS
3 11.95 TP53 SMAD4 KRAS GNAS
4 11.91 TP53 SMAD4 KRAS HRAS
5 11.85 REG4 MUC1 CEACAM5
6
Show member pathways
11.81 KRAS HRAS GNAS
7
Show member pathways
11.79 KRAS HRAS GNAS
8 11.76 TP53 SMAD4 HRAS
9
Show member pathways
11.76 MUC6 MUC5AC MUC1 KRAS HRAS
10
Show member pathways
11.58 TP53 KRAS HRAS
11
Show member pathways
11.49 MUC6 MUC5AC MUC1
12 11.47 TP53 SMAD4 KRAS HRAS
13
Show member pathways
11.42 GNAS HRAS KRAS
14 11.15 TP53 KRAS HRAS
15 11.14 TP53 KRAS HRAS
16 11.05 SMAD4 KRAS HRAS
17 10.88 SMAD4 KRAS HRAS
18 10.79 TP53 SMAD4 KRAS HRAS
19
Show member pathways
10.62 KRAS HRAS

GO Terms for Appendix Cancer

Biological processes related to Appendix Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell population proliferation GO:0042127 9.43 TP53 TMIGD1 SMAD4 HRAS
2 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 8.92 TP53 MUC1

Sources for Appendix Cancer

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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