MCID: APP010
MIFTS: 43

Appendix Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Appendix Cancer

MalaCards integrated aliases for Appendix Cancer:

Name: Appendix Cancer 12 15
Appendiceal Neoplasms 44 73
Appendiceal Neoplasm 12 15
Malignant Neoplasm of Appendix Vermiformis 12
Malignant Tumor of the Appendix 12
Malignant Neoplasm of Appendix 73
Malignant Tumor of Appendix 12
Carcinoma of the Appendix 73
Cancer of the Appendix 12
Neoplasm of Appendix 12
Appendix Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11239 DOID:11240
ICD10 33 C18.1
ICD9CM 35 153.5
MeSH 44 D001063
NCIt 50 C9333 C4434
SNOMED-CT 68 93679002

Summaries for Appendix Cancer

Disease Ontology : 12 A intestinal cancer that is located in the appendix.

MalaCards based summary : Appendix Cancer, also known as appendiceal neoplasms, is related to appendix adenocarcinoma and pseudomyxoma peritonei. An important gene associated with Appendix Cancer is KRT7 (Keratin 7), and among its related pathways/superpathways are CLEC7A (Dectin-1) signaling and O-linked glycosylation. The drugs Oxaliplatin and Cola have been mentioned in the context of this disorder. Affiliated tissues include appendix, colon and lung.

Wikipedia : 76 Appendix cancer or appendiceal cancers are rare malignancies of the vermiform... more...

Related Diseases for Appendix Cancer

Diseases related to Appendix Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 231)
# Related Disease Score Top Affiliating Genes
1 appendix adenocarcinoma 31.3 CDX2 KRT20 KRT7 RHCE YARS
2 pseudomyxoma peritonei 30.8 CDX2 KRT20 KRT7 MUC1 MUC2 MUC6
3 adenocarcinoma 29.9 GNAS MUC1 TP53
4 cystadenocarcinoma 29.7 KRT7 MUC1 MUC2 TP53
5 cystadenoma 29.5 KRT20 KRT7 MUC1 MUC2 MUC6
6 mucinous adenocarcinoma 29.3 CDX2 KRT20 KRT7 MUC1 MUC2
7 colorectal cancer 28.4 CDX2 GNAS KRT20 KRT7 MUC1 MUC2
8 appendix carcinoid tumor 11.1
9 appendicitis 10.3
10 gelatinous ascites 10.3
11 large cell neuroendocrine carcinoma 10.3 KRT20 KRT7
12 immune system organ benign neoplasm 10.3 KRT20 KRT7
13 thymus lipoma 10.3 KRT20 KRT7
14 ovarian brenner tumor 10.3 KRT20 KRT7
15 infiltrative basal cell carcinoma 10.3 KRT20 KRT7
16 clear cell adenocarcinoma 10.3 KRT20 KRT7
17 renal pelvis carcinoma 10.3 KRT20 KRT7
18 ovarian cystic teratoma 10.3 KRT20 KRT7
19 pulmonary hemosiderosis 10.2 KRT7 MUC1
20 sertoli-leydig cell tumor 10.2 KRT7 MUC1
21 spindle cell carcinoma 10.2 KRT7 MUC1
22 spindle cell sarcoma 10.2 KRT7 MUC1
23 intraneural perineurioma 10.2 KRT7 MUC1
24 sclerosing hemangioma 10.2 KRT7 MUC1
25 lipoadenoma 10.2 KRT7 MUC1
26 epithelioid sarcoma 10.2 KRT7 MUC1
27 pericardial mesothelioma 10.2 KRT7 MUC1
28 meconium ileus 10.2 MUC1 MUC2
29 well-differentiated liposarcoma 10.2 KRT7 MUC1
30 colloid carcinoma of the pancreas 10.2 MUC1 MUC2
31 brachydactyly, type e1 10.2 KRT20 MUC1
32 gastrointestinal carcinoma 10.2 KRT20 MUC1
33 cystic basal cell carcinoma 10.2 KRT20 KRT7
34 cervical adenosquamous carcinoma 10.2 KRT7 MUC6
35 dendritic cell tumor 10.2 KRT20 MUC1
36 seminal vesicle adenocarcinoma 10.2 KRT20 KRT7
37 transverse colon cancer 10.2 KRT20 KRT7
38 malignant syringoma 10.2 KRT20 KRT7
39 epstein-barr virus-associated gastric carcinoma 10.2 MUC2 MUC6
40 meningeal melanocytoma 10.2 MUC1 YARS
41 papillary transitional carcinoma 10.2 KRT20 KRT7
42 krukenberg carcinoma 10.2 KRT20 KRT7
43 large intestine adenocarcinoma 10.2 KRT20 KRT7
44 linitis plastica 10.2 KRT20 KRT7
45 sex cord-gonadal stromal tumor 10.2 GNAS KRT7
46 lung acinar adenocarcinoma 10.2 KRT20 KRT7
47 small cell carcinoma of the bladder 10.2 KRT20 KRT7
48 pregnancy adenoma 10.2 GNAS KRT7
49 adenoid squamous cell carcinoma 10.2 KRT20 KRT7
50 intratubular embryonal carcinoma 10.2 KRT20 KRT7

Comorbidity relations with Appendix Cancer via Phenotypic Disease Network (PDN):


Cecal Benign Neoplasm

Graphical network of the top 20 diseases related to Appendix Cancer:



Diseases related to Appendix Cancer

Symptoms & Phenotypes for Appendix Cancer

Drugs & Therapeutics for Appendix Cancer

Drugs for Appendix Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 146)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 43805 6857599 5310940 9887054
2 Cola Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
3 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
4
leucovorin Approved Phase 3,Phase 2,Phase 1 58-05-9 6006 143
5
Fluorouracil Approved Phase 3,Phase 2,Phase 1 51-21-8 3385
6
Paclitaxel Approved, Vet_approved Phase 3,Phase 1 33069-62-4 36314
7
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
9
Ondansetron Approved Phase 3 99614-02-5 4595
10
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
11
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
12 Pancreatic Polypeptide Investigational Phase 3,Phase 2,Phase 1 59763-91-6
13 Albumin-Bound Paclitaxel Phase 3,Phase 1
14 Central Nervous System Depressants Phase 3
15 Adjuvants, Anesthesia Phase 3
16 Anesthetics, Intravenous Phase 3
17 Analgesics, Opioid Phase 3
18 Peripheral Nervous System Agents Phase 3
19 Anesthetics, General Phase 3
20 Analgesics Phase 3
21 Narcotics Phase 3
22 Anesthetics Phase 3
23 BB 1101 Phase 3
24 Antipruritics Phase 3
25 Serotonin Agents Phase 3,Phase 2
26 Anti-Inflammatory Agents Phase 3
27 Hormone Antagonists Phase 3
28 Antipsychotic Agents Phase 3
29 Dermatologic Agents Phase 3,Not Applicable
30 Gastrointestinal Agents Phase 3,Phase 2
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
32 glucocorticoids Phase 3
33 Serotonin Antagonists Phase 3,Phase 2
34 Tranquilizing Agents Phase 3
35 Hormones Phase 3
36 Antineoplastic Agents, Hormonal Phase 3
37 Antiemetics Phase 3
38 Anti-Anxiety Agents Phase 3
39
protease inhibitors Phase 3
40 Autonomic Agents Phase 3
41 Psychotropic Drugs Phase 3
42 HIV Protease Inhibitors Phase 3
43 Neurotransmitter Agents Phase 3,Phase 2
44
Serotonin Investigational, Nutraceutical Phase 3,Phase 2 50-67-9 5202
45
Levoleucovorin Approved, Investigational Phase 2,Phase 1 68538-85-2
46
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
47
Pancrelipase Approved, Investigational Phase 2 53608-75-6
48
Melphalan Approved Phase 2 148-82-3 4053 460612
49
Floxuridine Approved Phase 2,Phase 1 50-91-9 5790
50
Nintedanib Approved Phase 2 656247-17-5 56843413

Interventional clinical trials:

(show all 43)
# Name Status NCT ID Phase Drugs
1 Relationship Between Platinum Levels in the Blood and Neurotoxicity in Patients Who Are Receiving Oxaliplatin for Gastrointestinal Cancer Unknown status NCT00274885 Phase 4 oxaliplatin
2 Debulking and Chemotherapy With or Without Intraperitoneal Chemotherapy to Treat Peritoneal Carcinomatosis Completed NCT00052962 Phase 3
3 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
4 Ondansetron With or Without Dexamethasone to Prevent Vomiting in Patients Receiving Radiation Therapy to the Upper Abdomen Completed NCT00016380 Phase 3 dexamethasone;ondansetron
5 Fluorouracil With or Without Mitomycin in Treating Patients With Peritoneal Cancer Unknown status NCT00006112 Phase 2 chemotherapy;fluorouracil;leucovorin calcium;mitomycin C
6 Thalidomide in Treating Patients Who Have Undergone Surgery and Chemotherapy for Cancer That Has Spread Throughout the Abdomen Due to Colorectal Cancer or Appendix Cancer Completed NCT00310076 Phase 2 thalidomide
7 Surgery and Oxaliplatin or Mitomycin C in Treating Patients With Tumors of the Appendix Completed NCT01580410 Phase 2 mitomycin C;oxaliplatin;hyperthermic intraperitoneal chemotherapy
8 Treating Peritoneal Carcinomatosis With PIPAC Completed NCT02320448 Phase 2 PIPAC
9 Hepatic Arterial Infusion of Melphalan With Hepatic Perfusion in Treating Patients With Unresectable Liver Cancer Completed NCT00096083 Phase 2 isolated perfusion;melphalan
10 LCI-GI-APX-NIN-001: Nintedanib in Metastatic Appendiceal Carcinoma Recruiting NCT03287947 Phase 2 nintedanib
11 ICARuS Post-operative Intraperitoneal Chemotherapy (EPIC) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) After Optimal Cytoreductive Surgery (CRS) for Neoplasms of the Appendix, Colon or Rectum With Isolated Peritoneal Metastasis Recruiting NCT01815359 Phase 2 HIPEC with Mitomycin-C;EPIC with FUDR and Leucovorin
12 A Phase 1/2 Study to Investigate the Safety, Biologic and Anti-tumor Activity of ONCOS-102 in Combination With Durvalumab in Subjects With Advanced Peritoneal Malignancies Recruiting NCT02963831 Phase 1, Phase 2 Durvalumab
13 Treatment of Peritoneal Carcinomatosis With Pressurized IntraPeritoneal Aerosol Chemotherapy - Recruiting NCT03287375 Phase 2 PIPAC
14 Antibiotic Treatment and Long-term Outcomes of Patients With Pseudomyxoma Peritonei of Appendiceal Origin Recruiting NCT02387203 Phase 2 PrevPac (Prevacid, Amoxicillin, Clarithromycin)
15 Single Arm Study Treating Patients of Peritoneal Surface Malignancy (Colorectal, Appendical, Pseudomyxoma, Gastric) With Cytoreductive Surgery and Hyperthermic Intraperitoneal Mitomycin-C Enrolling by invitation NCT02040142 Phase 2 Mitomycin C
16 Palonosetron Hydrochloride in Preventing Nausea and Vomiting Caused by Radiation Therapy in Patients With Primary Abdominal Cancer Terminated NCT00903396 Phase 2 palonosetron hydrochloride
17 Intraperitoneal Hyperthermic Perfusion With Oxaliplatin in Treating Patients With Stage IV Peritoneal Cancer Due to Appendix Cancer or Colorectal Cancer Completed NCT00458809 Phase 1 oxaliplatin
18 Oxaliplatin Plus Capecitabine in Treating Patients With Colorectal, Appendix, or Small Bowel Cancer Completed NCT00019773 Phase 1 capecitabine;oxaliplatin
19 Irinotecan, Fluorouracil, and Leucovorin in Treating Patients With Advanced Gastrointestinal Cancer Completed NCT00654160 Phase 1 fluorouracil;irinotecan hydrochloride;leucovorin calcium
20 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007) Completed NCT00031681 Phase 1 7-hydroxystaurosporine;irinotecan hydrochloride
21 Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer Completed NCT00397384 Phase 1 cetuximab;erlotinib hydrochloride
22 Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu Completed NCT00004074 Phase 1
23 Interleukin-12 in Treating Patients With Cancer in the Abdomen Completed NCT00003046 Phase 1
24 Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer Completed NCT00005842 Phase 1 tipifarnib
25 Oxaliplatin With Or Without Floxuridine and Leucovorin in Treating Patients With Metastatic Cancer of the Peritoneum Completed NCT00005860 Phase 1 floxuridine;leucovorin calcium;oxaliplatin
26 Aminocamptothecin in Treating Patients With Advanced Cancer of the Peritoneal Cavity Completed NCT00003548 Phase 1 aminocamptothecin colloidal dispersion
27 Irinotecan and Capecitabine in Treating Patients With Solid Tumors Completed NCT00003867 Phase 1 capecitabine;irinotecan hydrochloride
28 PV701 in Treating Patients With Advanced or Recurrent Peritoneal Cancer Completed NCT00055705 Phase 1
29 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
30 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
31 Capecitabine Combined With Cisplatin in Treating Patients With Locally Advanced or Metastatic Solid Tumors Completed NCT00010023 Phase 1 capecitabine;cisplatin
32 Trial of Intraperitoneal (IP) Oxaliplatin in Combination With Intravenous FOLFIRI Recruiting NCT02833753 Phase 1 Oxaliplatin
33 Safety and Effect of GL-ONC1 Administered IV Prior to Surgery to Patients With Solid Organ Cancers Undergoing Surgery Active, not recruiting NCT02714374 Phase 1
34 Quality of Life and Survivorship Care in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Completed NCT01126346 Not Applicable
35 Early Intervention vs. Standard Palliative Care in Improving End-of-Life Care in Advanced Cancer Patients Completed NCT00253383 Not Applicable
36 Gastrointestinal Microbiome Study of Appendiceal Cancer Recruiting NCT02599116 Not Applicable
37 Crossover Trial of Systemic Chemotherapy in Patients With Metastatic Well-Differentiated Mucinous Appendiceal Adenocarcinomas With Pseudomyxoma Peritonei Recruiting NCT01946854 Not Applicable
38 Radical Resection and HIPEC for Recurrent Retroperitoneal Sarcoma Recruiting NCT03792867 Not Applicable Doxorubicin
39 Trial of Cytoreductive Surgery and HIPEC in Patients With Primary and Secondary Peritoneal Cancers Recruiting NCT03604653 Mitomycin c;CDDP;CDDP;Doxorubicin
40 International Registry of Patients Treated With Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) Recruiting NCT03210298
41 The Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) Trial Recruiting NCT02800785 Not Applicable Cefoxitin, Ertapenem, Moxifloxacin, Tigecycline, Ticarcillin-Clavulanic Acid; Metronidazole plus Cefazolin, Cefuroxime, Ceftriaxone, Cefotaxime, Ciprofloxacin, or Levofloxacin
42 Postoperative Chemotherapy in High-Grade Appendiceal Adenocarcinoma With Peritoneal Carcinomatosis Active, not recruiting NCT02420509 systemic chemotherapy
43 EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung Cancer Terminated NCT00087191 Not Applicable EF5;motexafin lutetium

Search NIH Clinical Center for Appendix Cancer

Cochrane evidence based reviews: appendiceal neoplasms

Genetic Tests for Appendix Cancer

Anatomical Context for Appendix Cancer

MalaCards organs/tissues related to Appendix Cancer:

41
Appendix, Colon, Lung, Ovary, Pancreas, Thymus, Small Intestine

The Foundational Model of Anatomy Ontology organs/tissues related to Appendix Cancer:

19
The Appendix

Publications for Appendix Cancer

Articles related to Appendix Cancer:

(show all 43)
# Title Authors Year
1
Analysis of Appendiceal Neoplasms on 3544 Appendectomy Specimens for Acute Appendicitis: Retrospective Cohort Study of a Single Institution. ( 29947345 )
2018
2
Mucinous appendiceal neoplasms: pathologic classification, clinical implications, imaging spectrum and mimics. ( 29564494 )
2018
3
Single-center analysis of appendiceal neoplasms. ( 29731850 )
2018
4
Appendiceal Neoplasms. ( 30186049 )
2018
5
Diagnostic and therapeutic laparoscopy in assessment and management of patients with appendiceal neoplasms. ( 28605985 )
2018
6
Correction to: Tan et al., Diagnostic and therapeutic laparoscopy in assessment and management of patients with appendiceal neoplasms. ( 28967270 )
2018
7
Overinterpretation is common in pathological diagnosis of appendix cancer during patient referral for oncologic care. ( 28591173 )
2017
8
The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei. ( 28746986 )
2017
9
When and When Not to Perform a Right Colon Resection with Mucinous Appendiceal Neoplasms. ( 27770344 )
2017
10
Radical appendectomy as an alternative to right colon resection in patients with epithelial appendiceal neoplasms. ( 28317590 )
2017
11
Mucinous appendiceal neoplasms: Incidence, diagnosis and surgical treatment. ( 28655402 )
2017
12
Two concurrent appendiceal neoplasms in an elderly patient: A case report. ( 28988021 )
2017
13
Appendiceal Neoplasms. ( 29112557 )
2017
14
Expert Commentary on Appendiceal Neoplasms. ( 29112558 )
2017
15
Occult Appendiceal Neoplasms in Acute and Chronic Appendicitis: A Single-Institution Experience of 1793 Appendectomies. ( 29336758 )
2017
16
Preoperative CT and MRI prediction of non-resectability in patients treated for pseudomyxoma peritonei from mucinous appendiceal neoplasms. ( 26856956 )
2016
17
Outcomes of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemoperfusion in Patients with High-Grade, High-Volume Disseminated Mucinous Appendiceal Neoplasms. ( 26429720 )
2016
18
Prophylactic hyperthermic intraperitoneal chemotherapy in patients with epithelial appendiceal neoplasms. ( 27050712 )
2016
19
Management of Appendix Cancer. ( 26648795 )
2015
20
Recommendations in the management of epithelial appendiceal neoplasms and peritoneal dissemination from mucinous tumours (pseudomyxoma peritonei). ( 26489426 )
2015
21
Guidelines on the use of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with peritoneal surface malignancy arising from colorectal or appendiceal neoplasms. ( 25908915 )
2015
22
Evaluation of a new staging classification and a Peritoneal Surface Disease Severity Score (PSDSS) in 229 patients with mucinous appendiceal neoplasms with or without peritoneal dissemination. ( 24898451 )
2014
23
Does obesity affect outcomes of cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion for disseminated mucinous appendiceal neoplasms? ( 24916747 )
2014
24
Systemic Chemotherapy prior to Cytoreductive Surgery and HIPEC for Carcinomatosis from Appendix Cancer: Impact on Perioperative Outcomes and Short-Term Survival. ( 22899903 )
2012
25
Mucinous appendiceal neoplasms. Do we all speak the same language? ( 22300121 )
2012
26
Aggressive management of peritoneal carcinomatosis from mucinous appendiceal neoplasms. ( 22302270 )
2012
27
Inflammatory markers in blood and serum tumor markers predict survival in patients with epithelial appendiceal neoplasms undergoing surgical cytoreduction and intraperitoneal chemotherapy. ( 22750758 )
2012
28
Is malignant dedifferentiation for mucinous appendiceal neoplasms a valid phenomenon or merely histopathologic ambiguity? ( 21530846 )
2011
29
Significant association of appendiceal neoplasms and ulcerative colitis rather than Crohn's disease. ( 19705419 )
2010
30
Clinicopathological analysis of primary epithelial appendiceal neoplasms. ( 19851895 )
2010
31
Appendiceal mucinous cystadenoma is a neoplastic complication of IBD: case-control study of primary appendiceal neoplasms. ( 18989894 )
2009
32
Epithelial appendiceal neoplasms. ( 19556909 )
2009
33
Appendiceal neoplasms and pseudomyxoma peritonei: a population based study. ( 17524597 )
2008
34
Mucinous appendiceal neoplasms: preoperative MR staging and classification compared with surgical and histopathologic findings. ( 18287436 )
2008
35
The porta hepatis as a site of recurrence of mucinous appendiceal neoplasms treated by cytoreductive surgery and perioperative intraperitoneal chemotherapy. ( 19112943 )
2008
36
Appendiceal neoplasms with peritoneal dissemination: outcomes after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy. ( 16538401 )
2006
37
The "alphabet soup" of peritoneal dissemination from appendiceal neoplasms and other malignancies. ( 16538404 )
2006
38
Synchronous extraperitoneal and intraperitoneal dissemination of appendix cancer. ( 15336733 )
2004
39
Pseudomyxoma peritonei and selected other aspects of the spread of appendiceal neoplasms. ( 15807473 )
2004
40
Appendix cancer mimicking ovarian cancer. ( 12445258 )
2002
41
Surgical debulking and intraperitoneal chemotherapy for established peritoneal metastases from colon and appendix cancer. ( 11776492 )
2001
42
Primary appendiceal neoplasms. ( 8270409 )
1993
43
Mucinous adenocarcinoma of the appendix presenting as an ovarian cystadenocarcinoma: case report and review of appendiceal neoplasms with ovarian metastases. ( 3023143 )
1986

Variations for Appendix Cancer

Expression for Appendix Cancer

Search GEO for disease gene expression data for Appendix Cancer.

Pathways for Appendix Cancer

GO Terms for Appendix Cancer

Cellular components related to Appendix Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.8 MUC1 MUC2 MUC6

Biological processes related to Appendix Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 maintenance of gastrointestinal epithelium GO:0030277 9.26 MUC2 MUC6
2 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.16 MUC1 TP53
3 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.13 MUC1 MUC2 MUC6
4 O-glycan processing GO:0016266 8.8 MUC1 MUC2 MUC6

Sources for Appendix Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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