MCID: APP010
MIFTS: 41

Appendix Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Appendix Cancer

MalaCards integrated aliases for Appendix Cancer:

Name: Appendix Cancer 12 15
Appendiceal Neoplasms 44 73
Appendiceal Neoplasm 12 15
Malignant Neoplasm of Appendix Vermiformis 12
Malignant Tumor of the Appendix 12
Malignant Neoplasm of Appendix 73
Malignant Tumor of Appendix 12
Carcinoma of the Appendix 73
Cancer of the Appendix 12
Neoplasm of Appendix 12
Appendix Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11239 DOID:11240
ICD10 33 C18.1
ICD9CM 35 153.5
MeSH 44 D001063
NCIt 50 C9333 C4434

Summaries for Appendix Cancer

Disease Ontology : 12 A intestinal cancer that is located in the appendix.

MalaCards based summary : Appendix Cancer, also known as appendiceal neoplasms, is related to appendix adenocarcinoma and pseudomyxoma peritonei. An important gene associated with Appendix Cancer is KRT7 (Keratin 7), and among its related pathways/superpathways are Cytoskeletal Signaling and CLEC7A (Dectin-1) signaling. The drugs Oxaliplatin and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include the appendix, appendix and breast.

Wikipedia : 76 Appendix cancer or appendiceal cancers are rare malignancies of the vermiform... more...

Related Diseases for Appendix Cancer

Diseases related to Appendix Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 182)
# Related Disease Score Top Affiliating Genes
1 appendix adenocarcinoma 30.1 CDX2 KRT20 KRT7 RHCE YARS
2 pseudomyxoma peritonei 29.4 CDX2 KRAS KRT20 KRT7 MUC1 MUC2
3 ovarian cancer 27.8 KRAS KRT7 MUC1 MUC2
4 appendix carcinoid tumor 11.0
5 cystic basal cell carcinoma 10.7 KRT20 KRT7
6 seminal vesicle adenocarcinoma 10.7 KRT20 KRT7
7 transverse colon cancer 10.7 KRT20 KRT7
8 ovarian large-cell neuroendocrine carcinoma 10.7 KRT20 KRT7
9 eyelid neoplasm 10.7 KRT20 KRT7
10 malignant syringoma 10.7 KRT20 KRT7
11 krukenberg carcinoma 10.7 KRT20 KRT7
12 large intestine adenocarcinoma 10.7 KRT20 KRT7
13 linitis plastica 10.7 KRT20 KRT7
14 lung acinar adenocarcinoma 10.7 KRT20 KRT7
15 small cell carcinoma of the bladder 10.7 KRT20 KRT7
16 adenoid squamous cell carcinoma 10.7 KRT20 KRT7
17 eccrine sweat gland neoplasm 10.7 KRT20 KRT7
18 vulval paget's disease 10.7 KRT20 KRT7
19 intratubular embryonal carcinoma 10.7 KRT20 KRT7
20 meibomian cyst 10.7 KRT20 KRT7
21 bladder lymphoma 10.7 KRT20 KRT7
22 papillary serous adenocarcinoma 10.7 KRT20 KRT7
23 medulloepithelioma 10.7 KRT20 KRT7
24 glycogen-rich clear cell breast carcinoma 10.7 KRT20 KRT7
25 renal pelvis carcinoma 10.6 KRT20 KRT7
26 solid adenocarcinoma with mucin production 10.6 KRT7 MUC1
27 infiltrative basal cell carcinoma 10.6 KRT20 KRT7
28 endosalpingiosis 10.6 KRT7 MUC1
29 parachordoma 10.6 KRT7 MUC1
30 middle ear adenoma 10.6 KRT7 MUC1
31 immune system organ benign neoplasm 10.6 KRT20 KRT7
32 malignant mixed mullerian tumor 10.6 KRT7 MUC1
33 nodular hidradenoma 10.6 KRT7 MUC1
34 thymus lipoma 10.6 KRT20 KRT7
35 apocrine adenocarcinoma 10.6 KRT7 MUC1
36 monophasic synovial sarcoma 10.6 KRT7 MUC1
37 nephrogenic adenoma 10.6 KRT7 MUC1
38 chronic ethmoiditis 10.6 MUC1 MUC2
39 adenomyoma 10.6 KRT7 MUC1
40 spiradenoma 10.6 KRT7 MUC1
41 tn polyagglutination syndrome 10.6 MUC1 MUC2
42 hidradenoma 10.6 KRT7 MUC1
43 inverted papilloma 10.6 KRT20 KRT7
44 well-differentiated liposarcoma 10.5 KRT7 MUC1
45 ovarian cystic teratoma 10.5 KRT20 KRT7
46 sertoli-leydig cell tumor 10.5 KRT7 MUC1
47 large cell neuroendocrine carcinoma 10.5 KRT20 KRT7
48 spindle cell sarcoma 10.5 KRT7 MUC1
49 sclerosing hemangioma 10.5 KRT7 MUC1
50 lipoadenoma 10.5 KRT7 MUC1

Comorbidity relations with Appendix Cancer via Phenotypic Disease Network (PDN):


Cecal Benign Neoplasm

Graphical network of the top 20 diseases related to Appendix Cancer:



Diseases related to Appendix Cancer

Symptoms & Phenotypes for Appendix Cancer

Drugs & Therapeutics for Appendix Cancer

Drugs for Appendix Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 143)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
2 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
3 Cola Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
4
Fluorouracil Approved Phase 3,Phase 2,Phase 1 51-21-8 3385
5
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
6
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
7
Paclitaxel Approved, Vet_approved Phase 3,Phase 1 33069-62-4 36314
8
Ondansetron Approved Phase 3 99614-02-5 4595
9
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
10
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1 58-05-9 143 6006
11 Pancreatic Polypeptide Investigational Phase 3,Phase 2,Phase 1 59763-91-6
12 Dexamethasone acetate Phase 3 1177-87-3
13 Analgesics Phase 3
14 glucocorticoids Phase 3
15
protease inhibitors Phase 3
16 Central Nervous System Depressants Phase 3
17 Adjuvants, Anesthesia Phase 3
18 Albumin-Bound Paclitaxel Phase 3,Phase 1
19 Serotonin Agents Phase 3,Phase 2
20 Serotonin Antagonists Phase 3,Phase 2
21 Gastrointestinal Agents Phase 3,Phase 2
22 Narcotics Phase 3
23 Neurotransmitter Agents Phase 3,Phase 2
24 Analgesics, Opioid Phase 3
25 HIV Protease Inhibitors Phase 3
26 Anesthetics Phase 3
27 Hormone Antagonists Phase 3
28 Anesthetics, General Phase 3
29 Dermatologic Agents Phase 3,Not Applicable
30 Anesthetics, Intravenous Phase 3
31 Tranquilizing Agents Phase 3
32 Hormones Phase 3
33 Anti-Anxiety Agents Phase 3
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
35 Peripheral Nervous System Agents Phase 3
36 Antiemetics Phase 3
37 Anti-Inflammatory Agents Phase 3
38 Antipruritics Phase 3
39 Antipsychotic Agents Phase 3
40 Psychotropic Drugs Phase 3
41 BB 1101 Phase 3
42 Autonomic Agents Phase 3
43 Antineoplastic Agents, Hormonal Phase 3
44
Serotonin Investigational, Nutraceutical Phase 3,Phase 2 50-67-9 5202
45
Irinotecan Approved, Investigational Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
46
Levoleucovorin Approved, Investigational Phase 2,Phase 1 68538-85-2
47
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
48
Melphalan Approved Phase 2 148-82-3 4053 460612
49
Floxuridine Approved Phase 2,Phase 1 50-91-9 5790
50
Pancrelipase Approved, Investigational Phase 2 53608-75-6

Interventional clinical trials:

(show all 45)
# Name Status NCT ID Phase Drugs
1 Relationship Between Platinum Levels in the Blood and Neurotoxicity in Patients Who Are Receiving Oxaliplatin for Gastrointestinal Cancer Unknown status NCT00274885 Phase 4 oxaliplatin
2 Debulking and Chemotherapy With or Without Intraperitoneal Chemotherapy to Treat Peritoneal Carcinomatosis Completed NCT00052962 Phase 3
3 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
4 Ondansetron With or Without Dexamethasone to Prevent Vomiting in Patients Receiving Radiation Therapy to the Upper Abdomen Completed NCT00016380 Phase 3 dexamethasone;ondansetron
5 Fluorouracil With or Without Mitomycin in Treating Patients With Peritoneal Cancer Unknown status NCT00006112 Phase 2 chemotherapy;fluorouracil;leucovorin calcium;mitomycin C
6 Thalidomide in Treating Patients Who Have Undergone Surgery and Chemotherapy for Cancer That Has Spread Throughout the Abdomen Due to Colorectal Cancer or Appendix Cancer Completed NCT00310076 Phase 2 thalidomide
7 Surgery and Oxaliplatin or Mitomycin C in Treating Patients With Tumors of the Appendix Completed NCT01580410 Phase 2 mitomycin C;oxaliplatin;hyperthermic intraperitoneal chemotherapy
8 Treating Peritoneal Carcinomatosis With PIPAC Completed NCT02320448 Phase 2 PIPAC
9 Hepatic Arterial Infusion of Melphalan With Hepatic Perfusion in Treating Patients With Unresectable Liver Cancer Completed NCT00096083 Phase 2 isolated perfusion;melphalan
10 LCI-GI-APX-NIN-001: Nintedanib in Metastatic Appendiceal Carcinoma Recruiting NCT03287947 Phase 2 nintedanib
11 ICARuS Post-operative Intraperitoneal Chemotherapy (EPIC) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) After Optimal Cytoreductive Surgery (CRS) for Neoplasms of the Appendix, Colon or Rectum With Isolated Peritoneal Metastasis Recruiting NCT01815359 Phase 2 HIPEC with Mitomycin-C;EPIC with FUDR and Leucovorin
12 Treatment of Peritoneal Carcinomatosis With Pressurized IntraPeritoneal Aerosol Chemotherapy - Recruiting NCT03287375 Phase 2 PIPAC
13 Antibiotic Treatment and Long-term Outcomes of Patients With Pseudomyxoma Peritonei of Appendiceal Origin Recruiting NCT02387203 Phase 2 PrevPac (Prevacid, Amoxicillin, Clarithromycin)
14 Comparing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) Using Mitomycin-C Versus Melphalan for Colorectal Peritoneal Carcinomatosis Recruiting NCT03073694 Phase 2 Mitomycin c;Melphalan
15 Single Arm Study Treating Patients of Peritoneal Surface Malignancy (Colorectal, Appendical, Pseudomyxoma, Gastric) With Cytoreductive Surgery and Hyperthermic Intraperitoneal Mitomycin-C Enrolling by invitation NCT02040142 Phase 2
16 Palonosetron Hydrochloride in Preventing Nausea and Vomiting Caused by Radiation Therapy in Patients With Primary Abdominal Cancer Terminated NCT00903396 Phase 2 palonosetron hydrochloride
17 Treatment of a Cancerous Disease of the Peritoneum With Complete Cytoreductive Surgery and Intraperitoneal Chemohyperthermia Terminated NCT00180960 Phase 2 Oxaliplatin and irinotecan
18 Irinotecan and Capecitabine in Treating Patients With Solid Tumors Unknown status NCT00003867 Phase 1 capecitabine;irinotecan hydrochloride
19 Intraperitoneal Hyperthermic Perfusion With Oxaliplatin in Treating Patients With Stage IV Peritoneal Cancer Due to Appendix Cancer or Colorectal Cancer Completed NCT00458809 Phase 1 oxaliplatin
20 Oxaliplatin Plus Capecitabine in Treating Patients With Colorectal, Appendix, or Small Bowel Cancer Completed NCT00019773 Phase 1 capecitabine;oxaliplatin
21 Irinotecan, Fluorouracil, and Leucovorin in Treating Patients With Advanced Gastrointestinal Cancer Completed NCT00654160 Phase 1 fluorouracil;irinotecan hydrochloride;leucovorin calcium
22 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007) Completed NCT00031681 Phase 1 7-hydroxystaurosporine;irinotecan hydrochloride
23 Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer Completed NCT00397384 Phase 1 cetuximab;erlotinib hydrochloride
24 Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu Completed NCT00004074 Phase 1
25 Interleukin-12 in Treating Patients With Cancer in the Abdomen Completed NCT00003046 Phase 1
26 Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer Completed NCT00005842 Phase 1 tipifarnib
27 Oxaliplatin With Or Without Floxuridine and Leucovorin in Treating Patients With Metastatic Cancer of the Peritoneum Completed NCT00005860 Phase 1 floxuridine;leucovorin calcium;oxaliplatin
28 Aminocamptothecin in Treating Patients With Advanced Cancer of the Peritoneal Cavity Completed NCT00003548 Phase 1 aminocamptothecin colloidal dispersion
29 PV701 in Treating Patients With Advanced or Recurrent Peritoneal Cancer Completed NCT00055705 Phase 1
30 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
31 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
32 Capecitabine Combined With Cisplatin in Treating Patients With Locally Advanced or Metastatic Solid Tumors Completed NCT00010023 Phase 1 capecitabine;cisplatin
33 Trial of Intraperitoneal (IP) Oxaliplatin in Combination With Intravenous FOLFIRI Recruiting NCT02833753 Phase 1 Oxaliplatin
34 Safety and Effect of GL-ONC1 Administered IV Prior to Surgery to Patients With Solid Organ Cancers Undergoing Surgery Active, not recruiting NCT02714374 Phase 1
35 Quality of Life and Survivorship Care in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Completed NCT01126346 Not Applicable
36 Early Intervention vs. Standard Palliative Care in Improving End-of-Life Care in Advanced Cancer Patients Completed NCT00253383 Not Applicable
37 Knowledge, Attitudes, and Practice of Surgeons Toward Nutrition Support in HIPEC Patients Completed NCT02374411
38 Gastrointestinal Microbiome Study of Appendiceal Cancer Recruiting NCT02599116 Not Applicable
39 Crossover Trial of Systemic Chemotherapy in Patients With Metastatic Well-Differentiated Mucinous Appendiceal Adenocarcinomas With Pseudomyxoma Peritonei Recruiting NCT01946854 Not Applicable
40 International Registry of Patients Treated With Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) Recruiting NCT03210298
41 The Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) Trial Recruiting NCT02800785 Not Applicable Cefoxitin, Ertapenem, Moxifloxacin, Tigecycline, Ticarcillin-Clavulanic Acid; Metronidazole plus Cefazolin, Cefuroxime, Ceftriaxone, Cefotaxime, Ciprofloxacin, or Levofloxacin
42 Selective Rather Than Routine Histopathological Examination After Appendectomy and Cholecystectomy Recruiting NCT03510923
43 Postoperative Chemotherapy in High-Grade Appendiceal Adenocarcinoma With Peritoneal Carcinomatosis Active, not recruiting NCT02420509 systemic chemotherapy
44 Low vs. Standard Dose CT for Appendicitis Trial Active, not recruiting NCT01925014 Not Applicable
45 EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung Cancer Terminated NCT00087191 Not Applicable EF5;motexafin lutetium

Search NIH Clinical Center for Appendix Cancer

Cochrane evidence based reviews: appendiceal neoplasms

Genetic Tests for Appendix Cancer

Anatomical Context for Appendix Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Appendix Cancer:

19
The Appendix

MalaCards organs/tissues related to Appendix Cancer:

41
Appendix, Breast, Lung, Liver, Colon

Publications for Appendix Cancer

Articles related to Appendix Cancer:

(show all 26)
# Title Authors Year
1
Analysis of Appendiceal Neoplasms on 3544 Appendectomy Specimens for Acute Appendicitis: Retrospective Cohort Study of a Single Institution. ( 29947345 )
2018
2
Overinterpretation is common in pathological diagnosis of appendix cancer during patient referral for oncologic care. ( 28591173 )
2017
3
The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei. ( 28746986 )
2017
4
Corrigendum to "Diagnosis and Treatment of Mucinous Appendiceal Neoplasm Presented as Acute Appendicitis". ( 27957365 )
2016
5
Preoperative CT and MRI prediction of non-resectability in patients treated for pseudomyxoma peritonei from mucinous appendiceal neoplasms. ( 26856956 )
2016
6
Diagnosis and Treatment of Mucinous Appendiceal Neoplasm Presented as Acute Appendicitis. ( 27066284 )
2016
7
Ileocecal Intussusception Caused by an Appendiceal Neoplasm. ( 26831058 )
2016
8
Management of Appendix Cancer. ( 26648795 )
2015
9
Recommendations in the management of epithelial appendiceal neoplasms and peritoneal dissemination from mucinous tumours (pseudomyxoma peritonei). ( 26489426 )
2015
10
Low-grade appendiceal neoplasm presenting as a volvulus of the cecum. ( 24759968 )
2013
11
Pulmonary metastasis from a low grade mucinous appendiceal neoplasm. ( 23250037 )
2013
12
Systemic Chemotherapy prior to Cytoreductive Surgery and HIPEC for Carcinomatosis from Appendix Cancer: Impact on Perioperative Outcomes and Short-Term Survival. ( 22899903 )
2012
13
Delay of cytoreductive surgery and heated intraperitoneal chemotherapy in patients with appendiceal neoplasm. ( 22748531 )
2012
14
How should we treat mucinous appendiceal neoplasm? By laparoscopy or laparotomy? A case report. ( 20514834 )
2010
15
Appendiceal mucinous cystadenoma is a neoplastic complication of IBD: case-control study of primary appendiceal neoplasms. ( 18989894 )
2009
16
Incidence of synchronous appendiceal neoplasm in patients with colorectal cancer and its clinical significance. ( 19490638 )
2009
17
Diverticular disease of the vermiform appendix: a diagnostic clue to underlying appendiceal neoplasm. ( 18715614 )
2008
18
Appendiceal neoplasms and pseudomyxoma peritonei: a population based study. ( 17524597 )
2008
19
Early results of surgery in 123 patients with pseudomyxoma peritonei from a perforated appendiceal neoplasm. ( 17115339 )
2007
20
Management of an unexpected appendiceal neoplasm. ( 16775823 )
2006
21
Synchronous extraperitoneal and intraperitoneal dissemination of appendix cancer. ( 15336733 )
2004
22
Pseudomyxoma peritonei and selected other aspects of the spread of appendiceal neoplasms. ( 15807473 )
2004
23
Appendix cancer mimicking ovarian cancer. ( 12445258 )
2002
24
Surgical debulking and intraperitoneal chemotherapy for established peritoneal metastases from colon and appendix cancer. ( 11776492 )
2001
25
Mucinous adenocarcinoma of the appendix presenting as an ovarian cystadenocarcinoma: case report and review of appendiceal neoplasms with ovarian metastases. ( 3023143 )
1986
26
Adenocarcinoma of the colon associated with benign appendiceal neoplasm. ( 7089665 )
1982

Variations for Appendix Cancer

Expression for Appendix Cancer

Search GEO for disease gene expression data for Appendix Cancer.

Pathways for Appendix Cancer

Pathways related to Appendix Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.62 KRT20 KRT7 MUC1
2
Show member pathways
11.21 KRAS MUC1 MUC2

GO Terms for Appendix Cancer

Biological processes related to Appendix Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 8.8 KRAS MUC1 MUC2

Sources for Appendix Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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