Appendix Carcinoid Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Appendix Carcinoid Tumor

MalaCards integrated aliases for Appendix Carcinoid Tumor:

Name: Appendix Carcinoid Tumor ¹² ¹⁵

Appendix Carcinoid Endocrine Tumour ¹²

Carcinoid Tumor of Appendix ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050911

UMLS ⁷¹ C0334298

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Summaries for Appendix Carcinoid Tumor

Disease Ontology : ¹² An appendix cancer that has material basis in neurodendocrine cells.

MalaCards based summary : Appendix Carcinoid Tumor, also known as appendix carcinoid endocrine tumour, is related to goblet cell carcinoid and colon adenocarcinoma. An important gene associated with Appendix Carcinoid Tumor is PMS2 (PMS1 Homolog 2, Mismatch Repair System Component), and among its related pathways/superpathways are DNA Double-Strand Break Repair and DNA Damage. Affiliated tissues include appendix, and related phenotype is neoplasm.

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Related Diseases for Appendix Carcinoid Tumor

Diseases related to Appendix Carcinoid Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 289)

#	Related Disease	Score	Top Affiliating Genes
1	goblet cell carcinoid	29.7	ENO2 CHGA
2	colon adenocarcinoma	29.6	PMS2 MSH6 MLH1
3	lynch syndrome	29.4	PMS2 MSH6 MSH2 MLH1
4	carcinoid syndrome	29.1	SYP ENO2 CHGA
5	periampullary adenoma	10.3	PMS2 MSH6
6	fallopian tube endometrioid adenocarcinoma	10.3	PMS2 MSH6
7	esophageal tuberculosis	10.2	PMS2 MSH6
8	attenuated familial adenomatous polyposis	10.2	MSH6 MSH2
9	spindle cell intraocular melanoma	10.2	PMS2 MLH1
10	transverse colon cancer	10.2	PMS2 MLH1
11	colorectal cancer, hereditary nonpolyposis, type 4	10.2	PMS2 MLH1
12	legius syndrome	10.2	MSH6 MSH2
13	familial colorectal cancer	10.2	MSH2 MLH1
14	cerebral primitive neuroectodermal tumor	10.2	SYP MSH2
15	appendicitis	10.1
16	ascending colon cancer	10.1	MSH2 MLH1
17	b-lymphoblastic leukemia/lymphoma	10.1	MSH6 MSH2
18	lower lip cancer	10.1	MSH2 MLH1
19	anal fistula	10.1	MSH2 MLH1
20	melanocytic nevus syndrome, congenital	10.1	MSH2 MLH1
21	ureter, cancer of	10.1	MSH2 MLH1
22	uterine body mixed cancer	10.1	MSH2 MLH1
23	pituitary carcinoma	10.0	PMS2 CHGA
24	primary hepatic neuroendocrine carcinoma	10.0	SYP CHGA
25	acinar cell cystadenocarcinoma	10.0	SYP CHGA
26	vulvar eccrine porocarcinoma	10.0	SYP CHGA
27	cervical large cell neuroendocrine carcinoma	10.0	SYP CHGA
28	gastrointestinal neuroendocrine benign tumor	10.0	SYP CHGA
29	mixed ductal-endocrine carcinoma	10.0	SYP CHGA
30	polyposis syndrome, hereditary mixed, 1	10.0	MSH2 MLH1
31	esophageal neuroendocrine tumor	10.0	SYP CHGA
32	pancreatic serous cystadenocarcinoma	10.0	SYP CHGA
33	vaginal tubulovillous adenoma	10.0	SYP CHGA
34	papillary thymic adenocarcinoma	10.0	SYP CHGA
35	breast papillary carcinoma	10.0	SYP CHGA
36	gastrinoma	10.0	SYP CHGA
37	laryngeal neuroendocrine tumor	10.0	SYP CHGA
38	laryngeal small cell carcinoma	10.0	SYP CHGA
39	esophageal adenoid cystic carcinoma	10.0	SYP CHGA
40	gastric neuroendocrine neoplasm	10.0	SYP CHGA
41	appendix adenocarcinoma	10.0	SYP CHGA
42	pancreatic gastrinoma	10.0	SYP CHGA
43	gastrointestinal neuroendocrine tumor	10.0	SYP CHGA
44	pulmonary large cell neuroendocrine carcinoma	10.0	SYP CHGA
45	vaginal adenoma	10.0	SYP CHGA
46	binswanger's disease	10.0	SYP CHGA
47	pancreatic acinar cell adenocarcinoma	10.0	SYP CHGA
48	vaginal benign neoplasm	10.0	SYP CHGA
49	extra-adrenal pheochromocytoma	10.0	SYP CHGA
50	chordoid meningioma	10.0	SYP CHGA

Graphical network of the top 20 diseases related to Appendix Carcinoid Tumor:

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Symptoms & Phenotypes for Appendix Carcinoid Tumor

MGI Mouse Phenotypes related to Appendix Carcinoid Tumor:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	8.92	MLH1 MSH2 MSH6 PMS2

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Drugs & Therapeutics for Appendix Carcinoid Tumor

Search Clinical Trials , NIH Clinical Center for Appendix Carcinoid Tumor

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Genetic Tests for Appendix Carcinoid Tumor

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Anatomical Context for Appendix Carcinoid Tumor

MalaCards organs/tissues related to Appendix Carcinoid Tumor:

⁴⁰

Appendix

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Publications for Appendix Carcinoid Tumor

Articles related to Appendix Carcinoid Tumor:

#	Title	Authors	PMID	Year
1	Co-existence of idiopathic cecal ulcer and incidental appendix carcinoid tumor. ⁶¹	Ince V...Karakas S	28149127	2016
2	Ureteric obstruction: A unique case. ⁶¹	Ponnusamy K...Rajesh	22557728	2012
3	Natural behaviour and surgical treatment of appendiceal carcinoids: an analysis of 2,376 consecutive emergency appendectomies. ⁶¹	Ozer MT...Uzar AI	22180987	2011
4	[The carcinoid tumor of appendix]. ⁶¹	Guseinov AKh...Aliev IA	20919434	2010
5	A rare case of coexistence of carcinoid tumor of appendix vermicularis and ileal endometriosis. ⁶¹	Azordegan N...Moghadasian MH	18470525	2009
6	[Diagnosis, treatment, and prognosis of primary appendiceal tumors: analysis of 37 cases]. ⁶¹	You J...Qiu JF	19040005	2008
7	An appendix carcinoid tumor in a patient with hereditary nonpolyposis colorectal cancer. ⁶¹	Miquel C...Praz F	15619218	2004
8	[Clinical featares and treatment principles of appendix carcinoid tumor: a report of 13 cases]. ⁶¹	Zeng QA...Mo HS	15566684	2004
9	[Pregnancy and birth in appendix carcinoid tumor with familial disposition]. ⁶¹	Methfessel HD...Methfessel G	4691250	1973
10	Acute appendicitis associated with obstructing carcinoid tumor of appendix. A case report. ⁶¹	BROWN WT...PARRY NG	13805062	1960

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Genes for Appendix Carcinoid Tumor

Genes related to Appendix Carcinoid Tumor (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PMS2	PMS1 Homolog 2, Mismatch Repair System Component	Protein Coding	5.47	DISEASES inferred ¹⁵
2	MSH6	MutS Homolog 6	Protein Coding	5.34	DISEASES inferred ¹⁵
3	MSH2	MutS Homolog 2	Protein Coding	5.21	DISEASES inferred ¹⁵
4	MLH1	MutL Homolog 1	Protein Coding	5.07	DISEASES inferred ¹⁵
5	CHGA	Chromogranin A	Protein Coding	3.94	DISEASES inferred ¹⁵
6	ENO2	Enolase 2	Protein Coding	3.77	DISEASES inferred ¹⁵
7	SYP	Synaptophysin	Protein Coding	3.71	DISEASES inferred ¹⁵

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Variations for Appendix Carcinoid Tumor

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Expression for Appendix Carcinoid Tumor

Search GEO for disease gene expression data for Appendix Carcinoid Tumor.

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Pathways for Appendix Carcinoid Tumor

Pathways related to Appendix Carcinoid Tumor according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	DNA Double-Strand Break Repair ⁶⁵ Show member pathways Chk1/Chk2(Cds1) mediated inactivation of Cyclin B-Cdk1 complex ⁶⁵ DNA damage_DNA-damage-induced responses ²² DNA Repair ⁶⁵ G2/M DNA damage checkpoint ⁶⁵ HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) ⁶⁵ HDR through MMEJ (alt-NHEJ) ⁶⁵ Homology Directed Repair ⁶⁵ Non-homologous end joining ¹ Non-homologous end-joining ³⁶ Processing of DNA double-strand break ends ⁶⁵	12.78	PMS2 MSH6 MSH2 MLH1
2	DNA Damage ⁴	12.02	MSH6 MSH2 MLH1
3	Colorectal Cancer Metastasis ⁶³	11.72	MSH6 MSH2 MLH1
4	Direct p53 effectors ¹	11.55	PMS2 MSH2 MLH1
5	Mismatch repair ¹ ³⁶ ⁶⁵ Show member pathways Mismatch repair (MMR) directed by MSH2-MSH3 (MutSbeta) ⁶⁵ Mismatch repair (MMR) directed by MSH2-MSH6 (MutSalpha) ⁶⁵ Mismatch Repair in Eukaryotes ⁶³	11.23	PMS2 MSH6 MSH2 MLH1
6	Platinum drug resistance ³⁶	11.2	MSH6 MSH2 MLH1
7	Integrated Cancer Pathway ¹	11.12	MSH6 MSH2
8	Busulfan Pathway, Pharmacodynamics ⁶⁰ Show member pathways Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs) ¹ FMO oxidises nucleophiles ⁶⁵	11.08	MSH2 MLH1
9	Doxorubicin Pathway, Pharmacokinetics ⁶⁰ Show member pathways Doxorubicin Pathway (Cancer Cell), Pharmacodynamics ⁶⁰	11.01	MSH2 MLH1
10	Platinum Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.39	PMS2 MSH6 MSH2 MLH1

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GO Terms for Appendix Carcinoid Tumor

Cellular components related to Appendix Carcinoid Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	MutLalpha complex	GO:0032389	9.16	PMS2 MLH1
2	MutSalpha complex	GO:0032301	8.96	MSH6 MSH2
3	mismatch repair complex	GO:0032300	8.92	PMS2 MSH6 MSH2 MLH1

Biological processes related to Appendix Carcinoid Tumor according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to DNA damage stimulus	GO:0006974	9.81	PMS2 MSH6 MSH2 MLH1
2	DNA repair	GO:0006281	9.78	PMS2 MSH6 MSH2 MLH1
3	determination of adult lifespan	GO:0008340	9.54	MSH6 MSH2
4	intrinsic apoptotic signaling pathway in response to DNA damage	GO:0008630	9.54	MSH6 MSH2 MLH1
5	negative regulation of DNA recombination	GO:0045910	9.52	MSH6 MSH2
6	positive regulation of isotype switching to IgG isotypes	GO:0048304	9.49	MSH2 MLH1
7	positive regulation of helicase activity	GO:0051096	9.46	MSH6 MSH2
8	positive regulation of isotype switching to IgA isotypes	GO:0048298	9.43	MSH2 MLH1
9	isotype switching	GO:0045190	9.43	MSH6 MSH2 MLH1
10	maintenance of DNA repeat elements	GO:0043570	9.4	MSH6 MSH2
11	somatic recombination of immunoglobulin gene segments	GO:0016447	9.33	MSH6 MSH2 MLH1
12	somatic recombination of immunoglobulin genes involved in immune response	GO:0002204	9.32	MSH2 MLH1
13	mismatch repair	GO:0006298	9.26	PMS2 MSH6 MSH2 MLH1
14	somatic hypermutation of immunoglobulin genes	GO:0016446	8.92	PMS2 MSH6 MSH2 MLH1

Molecular functions related to Appendix Carcinoid Tumor according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	enzyme binding	GO:0019899	9.71	MSH6 MSH2 MLH1
2	magnesium ion binding	GO:0000287	9.67	MSH6 MSH2 ENO2
3	single-stranded DNA binding	GO:0003697	9.63	PMS2 MSH2 MLH1
4	ATPase activity	GO:0016887	9.56	PMS2 MSH6 MSH2 MLH1
5	damaged DNA binding	GO:0003684	9.55	MSH6 MSH2
6	DNA-dependent ATPase activity	GO:0008094	9.52	MSH6 MSH2
7	ADP binding	GO:0043531	9.51	MSH6 MSH2
8	four-way junction DNA binding	GO:0000400	9.48	MSH6 MSH2
9	MutSalpha complex binding	GO:0032407	9.43	PMS2 MLH1
10	MutLalpha complex binding	GO:0032405	9.4	MSH6 MSH2
11	oxidized purine DNA binding	GO:0032357	9.37	MSH6 MSH2
12	single guanine insertion binding	GO:0032142	9.32	MSH6 MSH2
13	single thymine insertion binding	GO:0032143	9.16	MSH6 MSH2
14	guanine/thymine mispair binding	GO:0032137	9.13	MSH6 MSH2 MLH1
15	mismatched DNA binding	GO:0030983	8.92	PMS2 MSH6 MSH2 MLH1

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Sources for Appendix Carcinoid Tumor

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