Appendix Carcinoid Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Appendix Carcinoid Tumor

MalaCards integrated aliases for Appendix Carcinoid Tumor:

Name: Appendix Carcinoid Tumor ¹² ¹⁵

Appendix Carcinoid Endocrine Tumour ¹²

Carcinoid Tumor of Appendix ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050911

UMLS ⁷³ C0334298

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Summaries for Appendix Carcinoid Tumor

Disease Ontology : ¹² An appendix cancer that has material basis in neurodendocrine cells.

MalaCards based summary : Appendix Carcinoid Tumor, also known as appendix carcinoid endocrine tumour, is related to colorectal cancer and carcinoid syndrome. An important gene associated with Appendix Carcinoid Tumor is PMS2 (PMS1 Homolog 2, Mismatch Repair System Component), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Regulation of TP53 Activity. Affiliated tissues include appendix, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Appendix Carcinoid Tumor

Diseases related to Appendix Carcinoid Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)

#	Related Disease	Score	Top Affiliating Genes
1	colorectal cancer	27.1	MLH1 MSH2 MSH6 PMS2
2	carcinoid syndrome	10.1
3	gastric leiomyoma	10.0	MLH1 MSH6
4	neurofibromatosis, type iv, of riccardi	9.8	MSH6 PMS2
5	skin melanoma	9.8	MLH1 PMS2
6	lower lip cancer	9.8	MLH1 MSH2
7	anal fistula	9.8	MLH1 MSH2
8	melanocytic nevus syndrome, congenital	9.7	MLH1 MSH2
9	childhood kidney cell carcinoma	9.7	MLH1 MSH2
10	small intestine cancer	9.7	MLH1 MSH2
11	keratoacanthoma	9.7	MLH1 MSH2
12	intestinal benign neoplasm	9.7	MLH1 MSH2
13	familial colorectal cancer	9.7	MLH1 MSH2
14	colorectal adenoma	9.6	MLH1 MSH2
15	attenuated familial adenomatous polyposis	9.6	MSH2 MSH6
16	hereditary breast ovarian cancer syndrome	9.6	MLH1 MSH2
17	legius syndrome	9.6	MSH2 MSH6
18	rectal neoplasm	9.6	MLH1 MSH2
19	ulcerative colitis	9.5	MLH1 MSH2
20	colitis	9.3	MLH1 MSH2
21	adamantinoma of long bones	9.2	MLH1 MSH2
22	cecum adenocarcinoma	9.1	MLH1 MSH2 MSH6
23	skin benign neoplasm	9.1	MLH1 MSH2 MSH6
24	colorectal adenocarcinoma	9.1	MLH1 MSH2 MSH6
25	familial adenomatous polyposis	9.0	MLH1 MSH2 MSH6
26	rhabdomyosarcoma	9.0	MSH2 MSH6 PMS2
27	adenoma	9.0	MLH1 MSH2
28	ovarian cancer	8.7	MLH1 MSH2 MSH6
29	adenosquamous colon carcinoma	8.5	MLH1 MSH2 MSH6 PMS2
30	sebaceous adenoma	8.5	MLH1 MSH2 MSH6 PMS2
31	lynch syndrome i	8.5	MLH1 MSH2 MSH6 PMS2
32	sebaceous adenocarcinoma	8.5	MLH1 MSH2 MSH6 PMS2
33	muir-torre syndrome	8.5	MLH1 MSH2 MSH6 PMS2
34	mismatch repair cancer syndrome	8.5	MLH1 MSH2 MSH6 PMS2
35	female reproductive organ cancer	8.5	MLH1 MSH2 MSH6 PMS2
36	autosomal genetic disease	8.5	MLH1 MSH2 MSH6 PMS2
37	autosomal dominant disease	8.5	MLH1 MSH2 MSH6 PMS2
38	gastrointestinal system cancer	8.5	MLH1 MSH2 MSH6 PMS2
39	lynch syndrome	8.4	MLH1 MSH2 MSH6 PMS2
40	endometrial cancer	8.4	MLH1 MSH2 MSH6 PMS2

Graphical network of the top 20 diseases related to Appendix Carcinoid Tumor:

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Symptoms & Phenotypes for Appendix Carcinoid Tumor

GenomeRNAi Phenotypes related to Appendix Carcinoid Tumor according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-104	9.81	PMS2
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-14	9.81	PMS2 MSH2
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-148	9.81	PMS2
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-153	9.81	PMS2
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-28	9.81	PMS2
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-53	9.81	MSH2
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-59	9.81	PMS2
8	Decreased shRNA abundance (Z-score < -2)	GR00366-A-98	9.81	PMS2
9	Increased viability with MLN4924 (a NAE inhibitor)	GR00250-A-3	9.26	MLH1 MSH2 MSH6 PMS2
10	Synthetic lethal with vaccinia virus (VACV) infection	GR00362-A	8.8	MLH1 MSH6 PMS2

MGI Mouse Phenotypes related to Appendix Carcinoid Tumor:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	8.92	MLH1 MSH2 MSH6 PMS2

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Drugs & Therapeutics for Appendix Carcinoid Tumor

Search Clinical Trials , NIH Clinical Center for Appendix Carcinoid Tumor

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Genetic Tests for Appendix Carcinoid Tumor

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Anatomical Context for Appendix Carcinoid Tumor

MalaCards organs/tissues related to Appendix Carcinoid Tumor:

⁴¹

Appendix

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Publications for Appendix Carcinoid Tumor

Articles related to Appendix Carcinoid Tumor:

#	Title	Authors	Year
1	Co-existence of idiopathic cecal ulcer and incidental appendix carcinoid tumor. ( 28149127 )	A^nce V....KarakaA9 S.	2016
2	An appendix carcinoid tumor in a patient with hereditary nonpolyposis colorectal cancer. ( 15619218 )	Miquel C....Praz F.	2004

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Genes for Appendix Carcinoid Tumor

Genes related to Appendix Carcinoid Tumor (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PMS2	PMS1 Homolog 2, Mismatch Repair System Component	Protein Coding	15.15	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	MSH6	MutS Homolog 6	Protein Coding	14.92	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	MSH2	MutS Homolog 2	Protein Coding	14.58	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	MLH1	MutL Homolog 1	Protein Coding	14.43	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Appendix Carcinoid Tumor

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Expression for Appendix Carcinoid Tumor

Search GEO for disease gene expression data for Appendix Carcinoid Tumor.

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Pathways for Appendix Carcinoid Tumor

Pathways related to Appendix Carcinoid Tumor according to GeneCards Suite gene sharing:

(show all 17)

#	Super pathways	Score	Top Affiliating Genes
1	DNA Double-Strand Break Repair ⁶⁶ Show member pathways Chk1/Chk2(Cds1) mediated inactivation of Cyclin B-Cdk1 complex ⁶⁶ DNA damage_DNA-damage-induced responses ²² DNA Repair ⁶⁶ G2/M DNA damage checkpoint ⁶⁶ HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) ⁶⁶ HDR through MMEJ (alt-NHEJ) ⁶⁶ Homology Directed Repair ⁶⁶ Non-homologous end joining ¹ Non-homologous end-joining ³⁷ Processing of DNA double-strand break ends ⁶⁶	12.67	MLH1 MSH2 MSH6 PMS2
2	Regulation of TP53 Activity ⁶⁶ Show member pathways Regulation of TP53 Activity through Association with Co-factors ⁶⁶ Regulation of TP53 Activity through Methylation ⁶⁶ Regulation of TP53 Activity through Phosphorylation ⁶⁶ Transcriptional Regulation by TP53 ⁶⁶	12.54	MLH1 MSH2 PMS2
3	TCR Signaling (Qiagen) ⁶⁴ Show member pathways Fc-EpsilonRI Pathway ⁶⁴ PDGF Pathway ⁶⁴ PKC-Theta Pathway ⁶⁴ TCR Signaling ⁶⁴	12.48	MLH1 MSH2 MSH6
4	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.43	MLH1 MSH2 MSH6
5	Pathways in cancer ³⁷	12.39	MLH1 MSH2 MSH6
6	DNA Damage ⁴	12.05	MLH1 MSH2 MSH6
7	Integrated Breast Cancer Pathway ¹	11.75	MSH2 MSH6
8	Colorectal Cancer Metastasis ⁶⁴	11.72	MLH1 MSH2 MSH6
9	Direct p53 effectors ¹	11.55	MLH1 MSH2 PMS2
10	Fanconi anemia pathway ⁶⁶ ³⁷	11.53	MLH1 PMS2
11	BRCA1 Pathway ⁶⁴ Show member pathways Fanconi's Anaemia Pathway ⁶⁴	11.46	MSH2 MSH6
12	Mismatch repair ³⁷ ⁶⁶ ¹ Show member pathways Mismatch repair (MMR) directed by MSH2-MSH3 (MutSbeta) ⁶⁶ Mismatch repair (MMR) directed by MSH2-MSH6 (MutSalpha) ⁶⁶ Mismatch Repair in Eukaryotes ⁶⁴	11.25	MLH1 MSH2 MSH6 PMS2
13	Platinum drug resistance ³⁷	11.2	MLH1 MSH2 MSH6
14	Integrated Cancer Pathway ¹	11.14	MSH2 MSH6
15	Busulfan Pathway, Pharmacodynamics ⁶¹ Show member pathways Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs) ¹ FMO oxidises nucleophiles ⁶⁶	11.1	MLH1 MSH2
16	Doxorubicin Pathway, Pharmacokinetics ⁶¹ Show member pathways Doxorubicin Pathway (Cancer Cell), Pharmacodynamics ⁶¹	11.03	MLH1 MSH2
17	Platinum Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹	10.39	MLH1 MSH2 MSH6 PMS2

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GO Terms for Appendix Carcinoid Tumor

Cellular components related to Appendix Carcinoid Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleoplasm	GO:0005654	9.56	MLH1 MSH2 MSH6 PMS2
2	MutLalpha complex	GO:0032389	9.16	MLH1 PMS2
3	MutSalpha complex	GO:0032301	8.96	MSH2 MSH6
4	mismatch repair complex	GO:0032300	8.92	MLH1 MSH2 MSH6 PMS2

Biological processes related to Appendix Carcinoid Tumor according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to DNA damage stimulus	GO:0006974	9.73	MLH1 MSH2 MSH6 PMS2
2	DNA repair	GO:0006281	9.71	MLH1 MSH2 MSH6 PMS2
3	determination of adult lifespan	GO:0008340	9.55	MSH2 MSH6
4	positive regulation of isotype switching to IgG isotypes	GO:0048304	9.54	MLH1 MSH2
5	positive regulation of helicase activity	GO:0051096	9.52	MSH2 MSH6
6	negative regulation of DNA recombination	GO:0045910	9.51	MSH2 MSH6
7	intrinsic apoptotic signaling pathway in response to DNA damage	GO:0008630	9.5	MLH1 MSH2 MSH6
8	maintenance of DNA repeat elements	GO:0043570	9.49	MSH2 MSH6
9	positive regulation of isotype switching to IgA isotypes	GO:0048298	9.48	MLH1 MSH2
10	meiotic mismatch repair	GO:0000710	9.46	MSH2 MSH6
11	isotype switching	GO:0045190	9.43	MLH1 MSH2 MSH6
12	somatic recombination of immunoglobulin genes involved in immune response	GO:0002204	9.37	MLH1 MSH2
13	somatic recombination of immunoglobulin gene segments	GO:0016447	9.33	MLH1 MSH2 MSH6
14	mismatch repair	GO:0006298	9.26	MLH1 MSH2 MSH6 PMS2
15	somatic hypermutation of immunoglobulin genes	GO:0016446	8.92	MLH1 MSH2 MSH6 PMS2

Molecular functions related to Appendix Carcinoid Tumor according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	ATP binding	GO:0005524	9.83	MLH1 MSH2 MSH6 PMS2
2	single-stranded DNA binding	GO:0003697	9.61	MLH1 MSH2 PMS2
3	magnesium ion binding	GO:0000287	9.57	MSH2 MSH6
4	double-stranded DNA binding	GO:0003690	9.56	MSH2 MSH6
5	ATPase activity	GO:0016887	9.56	MLH1 MSH2 MSH6 PMS2
6	damaged DNA binding	GO:0003684	9.55	MSH2 MSH6
7	DNA-dependent ATPase activity	GO:0008094	9.54	MSH2 MSH6
8	ADP binding	GO:0043531	9.51	MSH2 MSH6
9	four-way junction DNA binding	GO:0000400	9.49	MSH2 MSH6
10	oxidized purine DNA binding	GO:0032357	9.48	MSH2 MSH6
11	MutLalpha complex binding	GO:0032405	9.46	MSH2 MSH6
12	MutSalpha complex binding	GO:0032407	9.4	MLH1 PMS2
13	single guanine insertion binding	GO:0032142	9.37	MSH2 MSH6
14	guanine/thymine mispair binding	GO:0032137	9.33	MLH1 MSH2 MSH6
15	single thymine insertion binding	GO:0032143	9.32	MSH2 MSH6
16	single base insertion or deletion binding	GO:0032138	9.13	MSH2 MSH6 PMS2
17	mismatched DNA binding	GO:0030983	8.92	MLH1 MSH2 MSH6 PMS2

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