MCID: APP013
MIFTS: 27

Appendix Carcinoid Tumor

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Appendix Carcinoid Tumor

MalaCards integrated aliases for Appendix Carcinoid Tumor:

Name: Appendix Carcinoid Tumor 12 15
Appendix Carcinoid Endocrine Tumour 12
Carcinoid Tumor of Appendix 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050911
UMLS 71 C0334298

Summaries for Appendix Carcinoid Tumor

Disease Ontology : 12 An appendix cancer that has material basis in neurodendocrine cells.

MalaCards based summary : Appendix Carcinoid Tumor, also known as appendix carcinoid endocrine tumour, is related to carcinoid syndrome and colon adenocarcinoma. An important gene associated with Appendix Carcinoid Tumor is PMS2 (PMS1 Homolog 2, Mismatch Repair System Component), and among its related pathways/superpathways are DNA Double-Strand Break Repair and DNA Damage. Affiliated tissues include appendix, and related phenotype is neoplasm.

Related Diseases for Appendix Carcinoid Tumor

Diseases related to Appendix Carcinoid Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 286)
# Related Disease Score Top Affiliating Genes
1 carcinoid syndrome 29.9 SYP ENO2 CHGA
2 colon adenocarcinoma 29.8 PMS2 MSH6 MLH1
3 hereditary nonpolyposis colon cancer 29.6 PMS2 MSH6 MSH2 MLH1
4 lynch syndrome 29.6 PMS2 MSH6 MSH2 MLH1
5 periampullary adenoma 10.2 PMS2 MSH6
6 esophageal tuberculosis 10.2 PMS2 MSH6
7 fallopian tube endometrioid adenocarcinoma 10.2 PMS2 MSH6
8 silent pituitary adenoma 10.2 MSH6 MSH2
9 spindle cell intraocular melanoma 10.2 PMS2 MLH1
10 rectosigmoid cancer 10.2 PMS2 MSH6
11 transverse colon cancer 10.2 PMS2 MLH1
12 colorectal cancer, hereditary nonpolyposis, type 4 10.2 PMS2 MLH1
13 attenuated familial adenomatous polyposis 10.2 MSH6 MSH2
14 endometrioid ovary carcinoma 10.1 MSH6 MLH1
15 intracranial meningioma 10.1 MSH2 MLH1
16 legius syndrome 10.1 MSH6 MSH2
17 ascending colon cancer 10.1 MSH2 MLH1
18 lower lip cancer 10.1 MSH2 MLH1
19 anal fistula 10.1 MSH2 MLH1
20 melanocytic nevus syndrome, congenital 10.1 MSH2 MLH1
21 uterine body mixed cancer 10.1 MSH6 MLH1
22 pituitary carcinoma 10.1 PMS2 CHGA
23 ureter, cancer of 10.1 MSH2 MLH1
24 primary hepatic neuroendocrine carcinoma 10.0 SYP CHGA
25 esophageal neuroendocrine tumor 10.0 SYP CHGA
26 acinar cell cystadenocarcinoma 10.0 SYP CHGA
27 vulvar eccrine porocarcinoma 10.0 SYP CHGA
28 pancreatic serous cystadenocarcinoma 10.0 SYP CHGA
29 gastrointestinal neuroendocrine benign tumor 10.0 SYP CHGA
30 vaginal tubulovillous adenoma 10.0 SYP CHGA
31 mixed ductal-endocrine carcinoma 10.0 SYP CHGA
32 laryngeal small cell carcinoma 10.0 SYP CHGA
33 papillary thymic adenocarcinoma 10.0 SYP CHGA
34 duodenal benign neoplasm 10.0 SYP CHGA
35 breast papillary carcinoma 10.0 SYP CHGA
36 laryngeal neuroendocrine tumor 10.0 SYP CHGA
37 esophageal adenoid cystic carcinoma 10.0 SYP CHGA
38 gastric neuroendocrine neoplasm 10.0 SYP CHGA
39 appendix adenocarcinoma 10.0 SYP CHGA
40 pancreatic gastrinoma 10.0 SYP CHGA
41 glomangiomatosis 10.0 SYP CHGA
42 pulmonary large cell neuroendocrine carcinoma 10.0 SYP CHGA
43 vaginal adenoma 10.0 SYP CHGA
44 vaginal benign neoplasm 10.0 SYP CHGA
45 extra-adrenal pheochromocytoma 10.0 SYP CHGA
46 binswanger's disease 10.0 SYP CHGA
47 chordoid meningioma 10.0 SYP CHGA
48 pancreatic acinar cell adenocarcinoma 10.0 SYP CHGA
49 peritoneal serous adenocarcinoma 10.0 SYP CHGA
50 esophagus sarcoma 10.0 PMS2 MSH6 MSH2

Graphical network of the top 20 diseases related to Appendix Carcinoid Tumor:



Diseases related to Appendix Carcinoid Tumor

Symptoms & Phenotypes for Appendix Carcinoid Tumor

MGI Mouse Phenotypes related to Appendix Carcinoid Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 MLH1 MSH2 MSH6 PMS2

Drugs & Therapeutics for Appendix Carcinoid Tumor

Search Clinical Trials , NIH Clinical Center for Appendix Carcinoid Tumor

Genetic Tests for Appendix Carcinoid Tumor

Anatomical Context for Appendix Carcinoid Tumor

MalaCards organs/tissues related to Appendix Carcinoid Tumor:

40
Appendix

Publications for Appendix Carcinoid Tumor

Articles related to Appendix Carcinoid Tumor:

# Title Authors PMID Year
1
Co-existence of idiopathic cecal ulcer and incidental appendix carcinoid tumor. 61
28149127 2016
2
Ureteric obstruction: A unique case. 61
22557728 2012
3
Natural behaviour and surgical treatment of appendiceal carcinoids: an analysis of 2,376 consecutive emergency appendectomies. 61
22180987 2011
4
[The carcinoid tumor of appendix]. 61
20919434 2010
5
A rare case of coexistence of carcinoid tumor of appendix vermicularis and ileal endometriosis. 61
18470525 2009
6
[Diagnosis, treatment, and prognosis of primary appendiceal tumors: analysis of 37 cases]. 61
19040005 2008
7
An appendix carcinoid tumor in a patient with hereditary nonpolyposis colorectal cancer. 61
15619218 2004
8
[Clinical featares and treatment principles of appendix carcinoid tumor: a report of 13 cases]. 61
15566684 2004
9
[Pregnancy and birth in appendix carcinoid tumor with familial disposition]. 61
4691250 1973
10
Acute appendicitis associated with obstructing carcinoid tumor of appendix. A case report. 61
13805062 1960

Variations for Appendix Carcinoid Tumor

Expression for Appendix Carcinoid Tumor

Search GEO for disease gene expression data for Appendix Carcinoid Tumor.

Pathways for Appendix Carcinoid Tumor

GO Terms for Appendix Carcinoid Tumor

Cellular components related to Appendix Carcinoid Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutLalpha complex GO:0032389 9.16 PMS2 MLH1
2 MutSalpha complex GO:0032301 8.96 MSH6 MSH2
3 mismatch repair complex GO:0032300 8.92 PMS2 MSH6 MSH2 MLH1

Biological processes related to Appendix Carcinoid Tumor according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.81 PMS2 MSH6 MSH2 MLH1
2 DNA repair GO:0006281 9.78 PMS2 MSH6 MSH2 MLH1
3 determination of adult lifespan GO:0008340 9.54 MSH6 MSH2
4 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.54 MSH6 MSH2 MLH1
5 negative regulation of DNA recombination GO:0045910 9.52 MSH6 MSH2
6 positive regulation of isotype switching to IgG isotypes GO:0048304 9.49 MSH2 MLH1
7 positive regulation of helicase activity GO:0051096 9.46 MSH6 MSH2
8 positive regulation of isotype switching to IgA isotypes GO:0048298 9.43 MSH2 MLH1
9 isotype switching GO:0045190 9.43 MSH6 MSH2 MLH1
10 maintenance of DNA repeat elements GO:0043570 9.4 MSH6 MSH2
11 somatic recombination of immunoglobulin gene segments GO:0016447 9.33 MSH6 MSH2 MLH1
12 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.32 MSH2 MLH1
13 mismatch repair GO:0006298 9.26 PMS2 MSH6 MSH2 MLH1
14 somatic hypermutation of immunoglobulin genes GO:0016446 8.92 PMS2 MSH6 MSH2 MLH1

Molecular functions related to Appendix Carcinoid Tumor according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.71 MSH6 MSH2 MLH1
2 magnesium ion binding GO:0000287 9.67 MSH6 MSH2 ENO2
3 single-stranded DNA binding GO:0003697 9.63 PMS2 MSH2 MLH1
4 ATPase activity GO:0016887 9.62 PMS2 MSH6 MSH2 MLH1
5 damaged DNA binding GO:0003684 9.55 MSH6 MSH2
6 ADP binding GO:0043531 9.52 MSH6 MSH2
7 DNA-dependent ATPase activity GO:0008094 9.51 MSH6 MSH2
8 four-way junction DNA binding GO:0000400 9.48 MSH6 MSH2
9 MutSalpha complex binding GO:0032407 9.43 PMS2 MLH1
10 MutLalpha complex binding GO:0032405 9.4 MSH6 MSH2
11 oxidized purine DNA binding GO:0032357 9.37 MSH6 MSH2
12 single guanine insertion binding GO:0032142 9.26 MSH6 MSH2
13 single thymine insertion binding GO:0032143 9.16 MSH6 MSH2
14 guanine/thymine mispair binding GO:0032137 9.13 MSH6 MSH2 MLH1
15 mismatched DNA binding GO:0030983 8.92 PMS2 MSH6 MSH2 MLH1

Sources for Appendix Carcinoid Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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