MCID: APP013
MIFTS: 30

Appendix Carcinoid Tumor

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Appendix Carcinoid Tumor

MalaCards integrated aliases for Appendix Carcinoid Tumor:

Name: Appendix Carcinoid Tumor 12 15
Appendix Carcinoid Endocrine Tumour 12
Carcinoid Tumor of Appendix 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050911
UMLS 74 C0334298

Summaries for Appendix Carcinoid Tumor

Disease Ontology : 12 An appendix cancer that has material basis in neurodendocrine cells.

MalaCards based summary : Appendix Carcinoid Tumor, also known as appendix carcinoid endocrine tumour, is related to colorectal cancer and carcinoid syndrome. An important gene associated with Appendix Carcinoid Tumor is PMS2 (PMS1 Homolog 2, Mismatch Repair System Component), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Regulation of TP53 Activity. Affiliated tissues include appendix, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Appendix Carcinoid Tumor

Diseases related to Appendix Carcinoid Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 colorectal cancer 28.8 MLH1 MSH2 MSH6 PMS2
2 carcinoid syndrome 10.3
3 spindle cell intraocular melanoma 10.1 MLH1 PMS2
4 colorectal cancer 5 10.0 MLH1 MSH6
5 gastric leiomyoma 10.0 MLH1 MSH6
6 adenoma 9.9 MLH1 MSH2
7 neurofibromatosis, type iv, of riccardi 9.9 MSH6 PMS2
8 colorectal cancer, hereditary nonpolyposis, type 7 9.9 MLH1 MSH2
9 lower lip cancer 9.9 MLH1 MSH2
10 hereditary breast ovarian cancer syndrome 9.9 MLH1 MSH6
11 anal fistula 9.9 MLH1 MSH2
12 melanocytic nevus syndrome, congenital 9.8 MLH1 MSH2
13 childhood kidney cell carcinoma 9.8 MLH1 MSH2
14 intestinal benign neoplasm 9.8 MLH1 MSH2
15 keratoacanthoma 9.8 MLH1 MSH2
16 attenuated familial adenomatous polyposis 9.8 MSH2 MSH6
17 familial colorectal cancer 9.8 MLH1 MSH2
18 colorectal adenoma 9.8 MLH1 MSH2
19 legius syndrome 9.8 MSH2 MSH6
20 colon adenocarcinoma 9.7 MLH1 MSH6
21 gastrointestinal system disease 9.7 MLH1 MSH2
22 ulcerative colitis 9.7 MLH1 MSH2
23 colorectal cancer, hereditary nonpolyposis, type 4 9.6 MLH1 MSH2 PMS2
24 cecum adenocarcinoma 9.5 MLH1 MSH2 MSH6
25 skin benign neoplasm 9.5 MLH1 MSH2 MSH6
26 colorectal cancer, hereditary nonpolyposis, type 5 9.5 MLH1 MSH2 MSH6
27 colorectal adenocarcinoma 9.5 MLH1 MSH2 MSH6
28 female reproductive system disease 9.5 MLH1 MSH2 MSH6
29 familial adenomatous polyposis 9.5 MLH1 MSH2 MSH6
30 adamantinoma of long bones 9.5 MLH1 MSH2
31 rhabdomyosarcoma 9.5 MSH2 MSH6 PMS2
32 brain cancer 9.5 MSH2 MSH6 PMS2
33 ovarian cancer 9.4 MLH1 MSH2 MSH6
34 adenosquamous colon carcinoma 9.3 MLH1 MSH2 MSH6 PMS2
35 sebaceous adenoma 9.3 MLH1 MSH2 MSH6 PMS2
36 lynch syndrome 9.3 MLH1 MSH2 MSH6 PMS2
37 lynch syndrome i 9.3 MLH1 MSH2 MSH6 PMS2
38 sebaceous adenocarcinoma 9.3 MLH1 MSH2 MSH6 PMS2
39 muir-torre syndrome 9.3 MLH1 MSH2 MSH6 PMS2
40 small intestine cancer 9.3 MLH1 MSH2 MSH6 PMS2
41 mismatch repair cancer syndrome 9.3 MLH1 MSH2 MSH6 PMS2
42 uterine anomalies 9.3 MLH1 MSH2 MSH6 PMS2
43 colonic disease 9.3 MLH1 MSH2 MSH6 PMS2
44 autosomal genetic disease 9.3 MLH1 MSH2 MSH6 PMS2
45 intestinal disease 9.2 MLH1 MSH2 MSH6 PMS2
46 gastrointestinal system cancer 9.2 MLH1 MSH2 MSH6 PMS2
47 autosomal dominant disease 9.2 MLH1 MSH2 MSH6 PMS2
48 large intestine cancer 9.2 MLH1 MSH2 MSH6 PMS2
49 endometrial cancer 9.2 MLH1 MSH2 MSH6 PMS2

Graphical network of the top 20 diseases related to Appendix Carcinoid Tumor:



Diseases related to Appendix Carcinoid Tumor

Symptoms & Phenotypes for Appendix Carcinoid Tumor

GenomeRNAi Phenotypes related to Appendix Carcinoid Tumor according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.81 PMS2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.81 MSH2 PMS2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.81 PMS2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.81 PMS2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.81 PMS2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.81 MSH2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.81 PMS2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.81 PMS2
9 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.26 MLH1 MSH2 MSH6 PMS2
10 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.8 MLH1 MSH6 PMS2

MGI Mouse Phenotypes related to Appendix Carcinoid Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.46 MLH1 MSH2 MSH6 PMS2
2 immune system MP:0005387 9.26 MLH1 MSH2 MSH6 PMS2
3 neoplasm MP:0002006 8.92 MLH1 MSH2 MSH6 PMS2

Drugs & Therapeutics for Appendix Carcinoid Tumor

Search Clinical Trials , NIH Clinical Center for Appendix Carcinoid Tumor

Genetic Tests for Appendix Carcinoid Tumor

Anatomical Context for Appendix Carcinoid Tumor

MalaCards organs/tissues related to Appendix Carcinoid Tumor:

42
Appendix

Publications for Appendix Carcinoid Tumor

Articles related to Appendix Carcinoid Tumor:

# Title Authors Year
1
Co-existence of idiopathic cecal ulcer and incidental appendix carcinoid tumor. ( 28149127 )
2016
2
An appendix carcinoid tumor in a patient with hereditary nonpolyposis colorectal cancer. ( 15619218 )
2004

Variations for Appendix Carcinoid Tumor

Expression for Appendix Carcinoid Tumor

Search GEO for disease gene expression data for Appendix Carcinoid Tumor.

Pathways for Appendix Carcinoid Tumor

Pathways related to Appendix Carcinoid Tumor according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.71 MLH1 MSH2 MSH6 PMS2
2
Show member pathways
12.55 MLH1 MSH2 PMS2
3
Show member pathways
12.49 MLH1 MSH2 MSH6
4
Show member pathways
12.45 MLH1 MSH2 MSH6
5 12.41 MLH1 MSH2 MSH6
6 12.08 MLH1 MSH2 MSH6
7 11.76 MSH2 MSH6
8 11.72 MLH1 MSH2 MSH6
9 11.55 MLH1 MSH2 PMS2
10 11.54 MLH1 PMS2
11
Show member pathways
11.47 MSH2 MSH6
12
Show member pathways
11.25 MLH1 MSH2 MSH6 PMS2
13 11.2 MLH1 MSH2 MSH6
14 11.16 MSH2 MSH6
15 11.15 MLH1 MSH2 MSH6
16
Show member pathways
11.12 MLH1 MSH2
17
Show member pathways
11.06 MLH1 MSH2
18 10.39 MLH1 MSH2 MSH6 PMS2

GO Terms for Appendix Carcinoid Tumor

Cellular components related to Appendix Carcinoid Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.56 MLH1 MSH2 MSH6 PMS2
2 MutLalpha complex GO:0032389 9.16 MLH1 PMS2
3 MutSalpha complex GO:0032301 8.96 MSH2 MSH6
4 mismatch repair complex GO:0032300 8.92 MLH1 MSH2 MSH6 PMS2

Biological processes related to Appendix Carcinoid Tumor according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.73 MLH1 MSH2 MSH6 PMS2
2 DNA repair GO:0006281 9.71 MLH1 MSH2 MSH6 PMS2
3 negative regulation of DNA recombination GO:0045910 9.57 MSH2 MSH6
4 determination of adult lifespan GO:0008340 9.56 MSH2 MSH6
5 positive regulation of isotype switching to IgG isotypes GO:0048304 9.55 MLH1 MSH2
6 positive regulation of helicase activity GO:0051096 9.54 MSH2 MSH6
7 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.5 MLH1 MSH2 MSH6
8 maintenance of DNA repeat elements GO:0043570 9.49 MSH2 MSH6
9 positive regulation of isotype switching to IgA isotypes GO:0048298 9.48 MLH1 MSH2
10 isotype switching GO:0045190 9.43 MLH1 MSH2 MSH6
11 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.37 MLH1 MSH2
12 somatic recombination of immunoglobulin gene segments GO:0016447 9.33 MLH1 MSH2 MSH6
13 interstrand cross-link repair GO:0036297 9.27 MSH6
14 mismatch repair GO:0006298 9.26 MLH1 MSH2 MSH6 PMS2
15 pyrimidine dimer repair GO:0006290 9.22 MSH6
16 replication fork arrest GO:0043111 9.21 MSH6
17 meiotic mismatch repair GO:0000710 9.16 MSH6
18 somatic hypermutation of immunoglobulin genes GO:0016446 8.92 MLH1 MSH2 MSH6 PMS2

Molecular functions related to Appendix Carcinoid Tumor according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.8 MLH1 MSH2 MSH6 PMS2
2 chromatin binding GO:0003682 9.72 MLH1 MSH2 MSH6
3 enzyme binding GO:0019899 9.69 MLH1 MSH2 MSH6
4 double-stranded DNA binding GO:0003690 9.57 MSH2 MSH6
5 damaged DNA binding GO:0003684 9.56 MSH2 MSH6
6 DNA-dependent ATPase activity GO:0008094 9.54 MSH2 MSH6
7 single-stranded DNA binding GO:0003697 9.54 MLH1 MSH2 PMS2
8 ADP binding GO:0043531 9.52 MSH2 MSH6
9 four-way junction DNA binding GO:0000400 9.48 MSH2 MSH6
10 MutLalpha complex binding GO:0032405 9.46 MSH2 MSH6
11 ATPase activity GO:0016887 9.46 MLH1 MSH2 MSH6 PMS2
12 MutSalpha complex binding GO:0032407 9.43 MLH1 PMS2
13 oxidized purine DNA binding GO:0032357 9.4 MSH2 MSH6
14 single thymine insertion binding GO:0032143 9.32 MSH2 MSH6
15 single guanine insertion binding GO:0032142 9.26 MSH2 MSH6
16 guanine/thymine mispair binding GO:0032137 9.13 MLH1 MSH2 MSH6
17 mismatched DNA binding GO:0030983 8.92 MLH1 MSH2 MSH6 PMS2

Sources for Appendix Carcinoid Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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