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MCID: APP013
MIFTS: 27

Appendix Carcinoid Tumor

Categories: Cancer diseases, Gastrointestinal diseases
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Aliases & Classifications for Appendix Carcinoid Tumor

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MalaCards integrated aliases for Appendix Carcinoid Tumor:

Name: Appendix Carcinoid Tumor 11 14
Appendix Carcinoid Endocrine Tumour 11
Carcinoid Tumor of Appendix 71

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 11 DOID:0050911
UMLS 71 C0334298
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Summaries for Appendix Carcinoid Tumor

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Disease Ontology: 11 An appendix cancer that has material basis in neurodendocrine cells.

MalaCards based summary: Appendix Carcinoid Tumor, also known as appendix carcinoid endocrine tumour, is related to carcinoid syndrome and carcinoid tumors, intestinal. An important gene associated with Appendix Carcinoid Tumor is CHGA (Chromogranin A), and among its related pathways/superpathways are Homologous DNA Pairing and Strand Exchange and DNA Damage. Affiliated tissues include appendix, and related phenotypes are neoplasm and cellular
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Related Diseases for Appendix Carcinoid Tumor

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Diseases related to Appendix Carcinoid Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 308)
# Related Disease Score Top Affiliating Genes
1 carcinoid syndrome 30.5 SYP ENO2 CHGA
2 carcinoid tumors, intestinal 30.5 SYP ENO2 CHGA
3 adenocarcinoma 29.0 MSH6 MSH2 MLH1 CHGA CD274
4 lynch syndrome 29.0 PMS2 MSH6 MSH2 MLH1 CD274
5 pancreas lymphoma 10.3 SYP CHGA
6 vaginal tubulovillous adenoma 10.3 SYP CHGA
7 mixed ductal-endocrine carcinoma 10.3 SYP CHGA
8 vulvar eccrine porocarcinoma 10.3 SYP CHGA
9 cervical large cell neuroendocrine carcinoma 10.3 SYP CHGA
10 duodenal benign neoplasm 10.3 SYP CHGA
11 acinar cell cystadenocarcinoma 10.3 SYP CHGA
12 papillary thymic adenocarcinoma 10.2 SYP CHGA
13 breast papillary carcinoma 10.2 SYP CHGA
14 gastric gastrinoma 10.2 SYP CHGA
15 binswanger's disease 10.2 SYP CHGA
16 benign perivascular tumor 10.2 SYP CHGA
17 gastrointestinal neuroendocrine benign tumor 10.2 SYP CHGA
18 duodenal gastrinoma 10.2 SYP CHGA
19 glomangioma 10.2 SYP CHGA
20 extra-adrenal pheochromocytoma 10.2 SYP CHGA
21 pancreatic gastrinoma 10.2 SYP CHGA
22 ovary leiomyosarcoma 10.2 SYP CHGA
23 benign ileal neoplasm 10.2 SYP CHGA
24 thyroid gland hurthle cell carcinoma 10.2 SYP CHGA
25 vaginal adenoma 10.2 SYP CHGA
26 thymus large cell carcinoma 10.2 SYP CHGA
27 pancreatic acinar cell adenocarcinoma 10.2 SYP CHGA
28 gastric neuroendocrine neoplasm 10.2 SYP CHGA
29 vaginal benign neoplasm 10.2 SYP CHGA
30 laryngeal small cell carcinoma 10.2 SYP CHGA
31 esophageal neuroendocrine tumor 10.2 SYP CHGA
32 sclerosing hemangioma 10.2 SYP CHGA
33 periampullary adenoma 10.2 PMS2 MSH6
34 gallbladder adenocarcinoma 10.2 SYP CHGA
35 pulmonary sclerosing hemangioma 10.2 SYP CHGA
36 pulsating exophthalmos 10.2 PMS2 MSH6
37 bladder small cell carcinoma 10.2 SYP ENO2
38 vaginal glandular tumor 10.2 ENO2 CHGA
39 papillary ependymoma 10.2 SYP MSH2
40 clear cell ependymoma 10.2 SYP MSH2
41 malignant melanocytic neoplasm of the peripheral nerve sheath 10.2 SYP ENO2
42 goblet cell carcinoid 10.2 ENO2 CHGA
43 cecal disease 10.2 SYP CHGA
44 anal neuroendocrine tumor 10.2 SYP ENO2
45 neuronal intestinal dysplasia, type b 10.2 SYP ENO2
46 optic nerve astrocytoma 10.2 SYP ENO2
47 cloacogenic carcinoma 10.2 SYP ENO2
48 cervical endometrioid adenocarcinoma 10.2 MSH6 MSH2
49 pineal region teratoma 10.2 SYP ENO2
50 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.1 SYP ENO2

Graphical network of the top 20 diseases related to Appendix Carcinoid Tumor:



Diseases related to Appendix Carcinoid Tumor
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Symptoms & Phenotypes for Appendix Carcinoid Tumor

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MGI Mouse Phenotypes related to Appendix Carcinoid Tumor:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.35 MLH1 MSH2 MSH6 PMS2 POMC
2 cellular MP:0005384 9.17 CD274 ENO2 MLH1 MSH2 MSH6 PMS2
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Drugs & Therapeutics for Appendix Carcinoid Tumor

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Search Clinical Trials, NIH Clinical Center for Appendix Carcinoid Tumor

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Genetic Tests for Appendix Carcinoid Tumor

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Anatomical Context for Appendix Carcinoid Tumor

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Organs/tissues related to Appendix Carcinoid Tumor:

MalaCards : Appendix
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Publications for Appendix Carcinoid Tumor

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Articles related to Appendix Carcinoid Tumor:

# Title Authors PMID Year
1
Durable complete response to pembrolizumab in microsatellite stable colorectal cancer. 62
34254265 2021
2
[Clinical and laboratory characteristics and results of treatment of patients with ACTH-producing neuroendocrine tumors of various localization]. 62
36286818 2021
3
Endometriosis and its correlation with carcinoid tumor of the appendix: a systematic review. 62
33904692 2021
4
Co-existence of idiopathic cecal ulcer and incidental appendix carcinoid tumor. 62
28149127 2016
5
[Diagnosis, treatment, and prognosis of primary appendiceal tumors: analysis of 37 cases]. 62
19040005 2008
6
An appendix carcinoid tumor in a patient with hereditary nonpolyposis colorectal cancer. 62
15619218 2004
7
[Clinical featares and treatment principles of appendix carcinoid tumor: a report of 13 cases]. 62
15566684 2004
8
[Pregnancy and birth in appendix carcinoid tumor with familial disposition]. 62
4691250 1973
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Variations for Appendix Carcinoid Tumor

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Expression for Appendix Carcinoid Tumor

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Search GEO for disease gene expression data for Appendix Carcinoid Tumor.
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Pathways for Appendix Carcinoid Tumor

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Pathways related to Appendix Carcinoid Tumor according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Homologous DNA Pairing and Strand Exchange 66
Show member pathways
 12.27 PMS2 MSH6 MSH2 MLH1
2
DNA Damage 3
12.12 MSH6 MSH2 MLH1
3
DNA repair pathways, full network 74
Show member pathways
 12.12 PMS2 MSH6 MSH2 MLH1
4
Base excision repair 74
Show member pathways
 11.86 PMS2 MSH6 MSH2 MLH1
5
Colorectal Cancer Metastasis 64
11.8 MSH6 MSH2 MLH1
6
Direct p53 effectors 61
11.65 PMS2 MSH2 MLH1
7
Busulfan Pathway, Pharmacodynamics 60
Show member pathways
 11.15 MSH2 MLH1
8
Doxorubicin Pathway, Pharmacokinetics 60
Show member pathways
 11.06 MSH2 MLH1
9
Integrated cancer pathway 74
11.01 MSH6 MSH2
10
Platinum Pathway, Pharmacokinetics/Pharmacodynamics 60
10.39 PMS2 MSH6 MSH2 MLH1
11
Defective Mismatch Repair Associated With PMS2 66
Show member pathways
 9.56 PMS2 MLH1
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GO Terms for Appendix Carcinoid Tumor

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Cellular components related to Appendix Carcinoid Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutLalpha complex GO:0032389 9.46 PMS2 MLH1
2 MutSalpha complex GO:0032301 9.26 MSH6 MSH2
3 mismatch repair complex GO:0032300 9.02 PMS2 MSH2 MLH1

Biological processes related to Appendix Carcinoid Tumor according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 DNA repair GO:0006281 9.97 PMS2 MSH6 MSH2 MLH1
2 determination of adult lifespan GO:0008340 9.84 MSH6 MSH2
3 cellular response to DNA damage stimulus GO:0006974 9.83 PMS2 MSH6 MSH2 MLH1
4 negative regulation of DNA recombination GO:0045910 9.81 MSH6 MSH2
5 positive regulation of isotype switching to IgG isotypes GO:0048304 9.78 MSH2 MLH1
6 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.77 MLH1 MSH2 MSH6
7 positive regulation of helicase activity GO:0051096 9.76 MSH6 MSH2
8 mismatch repair GO:0006298 9.76 PMS2 MSH6 MSH2 MLH1
9 positive regulation of isotype switching to IgA isotypes GO:0048298 9.73 MSH2 MLH1
10 isotype switching GO:0045190 9.73 MSH6 MSH2 MLH1
11 maintenance of DNA repeat elements GO:0043570 9.58 MSH6 MSH2
12 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.5 MSH2 MLH1
13 somatic recombination of immunoglobulin gene segments GO:0016447 9.35 MSH6 MSH2 MLH1
14 somatic hypermutation of immunoglobulin genes GO:0016446 9.23 PMS2 MSH6 MSH2 MLH1

Molecular functions related to Appendix Carcinoid Tumor according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 10.1 MSH6 MSH2 MLH1 ENO2
2 single-stranded DNA binding GO:0003697 9.93 PMS2 MSH2 MLH1
3 four-way junction DNA binding GO:0000400 9.78 MSH6 MSH2
4 MutSalpha complex binding GO:0032407 9.73 PMS2 MLH1
5 oxidized purine DNA binding GO:0032357 9.71 MSH2 MSH6
6 MutLalpha complex binding GO:0032405 9.67 MSH2 MSH6
7 guanine/thymine mispair binding GO:0032137 9.63 MSH6 MSH2 MLH1
8 single guanine insertion binding GO:0032142 9.62 MSH6 MSH2
9 single thymine insertion binding GO:0032143 9.56 MSH6 MSH2
10 ATP-dependent DNA damage sensor activity GO:0140664 9.56 PMS2 MSH6 MSH2 MLH1
11 mismatched DNA binding GO:0030983 9.1 PMS2 MSH6 MSH2 MLH1
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Sources for Appendix Carcinoid Tumor

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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