MCID: APP018
MIFTS: 29

Appendix Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Appendix Disease

MalaCards integrated aliases for Appendix Disease:

Name: Appendix Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:60000
ICD10 33 K35-K38 K38.8

Summaries for Appendix Disease

Disease Ontology : 12 A gastrointestinal system disease that is located in the appendix.

MalaCards based summary : Appendix Disease is related to suppurative cholangitis and sex cord-gonadal stromal tumor. An important gene associated with Appendix Disease is MUC2 (Mucin 2, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are Circadian entrainment and fMLP Pathway. Affiliated tissues include appendix, lung and colon, and related phenotype is neoplasm.

Related Diseases for Appendix Disease

Diseases related to Appendix Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 suppurative cholangitis 10.2 CDX2 MUC2
2 sex cord-gonadal stromal tumor 10.2 GNAS KRT7
3 bile duct mucoepidermoid carcinoma 10.2 KRT7 MUC2
4 ovary neuroendocrine neoplasm 10.2 CDX2 KRT7
5 ovarian clear cell carcinoma 10.2 KRAS KRT7
6 mucinous adenofibroma 10.2 CDX2 KRT7
7 papillary adenocarcinoma 10.2 KRT7 MUC2
8 anus adenocarcinoma 10.2 CDX2 KRT7
9 chronic cholangitis 10.2 CDX2 MUC2
10 epithelial predominant wilms' tumor 10.2 CDX2 KRT7
11 large cell neuroendocrine carcinoma 10.2 KRT20 KRT7
12 ovarian brenner tumor 10.2 KRT20 KRT7
13 inverted papilloma 10.2 KRT20 KRT7
14 mammary paget's disease 10.2 KRT20 KRT7
15 dysgerminoma 10.2 KRT20 KRT7
16 clear cell adenocarcinoma 10.2 KRT20 KRT7
17 nasal cavity cancer 10.2 CDX2 KRT7
18 mucinous ovarian cystadenoma 10.2 CDX2 KRT7
19 polyposis, skin pigmentation, alopecia, and fingernail changes 10.2 CDX2 MUC2
20 cystic basal cell carcinoma 10.2 KRT20 KRT7
21 tn polyagglutination syndrome 10.2 MUC2 MUC6
22 colorectal cancer 1 10.2 MUC2 MUC6
23 seminal vesicle adenocarcinoma 10.2 KRT20 KRT7
24 epstein-barr virus-associated gastric carcinoma 10.2 MUC2 MUC6
25 transverse colon cancer 10.2 KRT20 KRT7
26 malignant syringoma 10.1 KRT20 KRT7
27 urachal adenocarcinoma 10.1 GNAS KRAS
28 papillary transitional carcinoma 10.1 KRT20 KRT7
29 vaginal benign neoplasm 10.1 CDX2 KRT20
30 krukenberg carcinoma 10.1 KRT20 KRT7
31 vaginal adenoma 10.1 CDX2 KRT20
32 vaginal tubulovillous adenoma 10.1 CDX2 KRT20
33 large intestine adenocarcinoma 10.1 KRT20 KRT7
34 linitis plastica 10.1 KRT20 KRT7
35 lung acinar adenocarcinoma 10.1 KRT20 KRT7
36 small cell carcinoma of the bladder 10.1 KRT20 KRT7
37 adenoid squamous cell carcinoma 10.1 KRT20 KRT7
38 intratubular embryonal carcinoma 10.1 KRT20 KRT7
39 vulval paget's disease 10.1 KRT20 KRT7
40 bile duct adenoma 10.1 KRT20 KRT7
41 alveoli adenoma 10.1 KRAS KRT7
42 meibomian cyst 10.1 KRT20 KRT7
43 bladder lymphoma 10.1 KRT20 KRT7
44 papillary serous adenocarcinoma 10.1 KRT20 KRT7
45 small intestine adenocarcinoma 10.1 MUC2 MUC6
46 medulloepithelioma 10.1 KRT20 KRT7
47 glycogen-rich clear cell breast carcinoma 10.1 KRT20 KRT7
48 microinvasive gastric cancer 10.1 CDX2 MUC2
49 solid adenocarcinoma with mucin production 10.1 KRT7 MUC6
50 chronic ethmoiditis 10.1 MUC2 MUC6

Graphical network of the top 20 diseases related to Appendix Disease:



Diseases related to Appendix Disease

Symptoms & Phenotypes for Appendix Disease

MGI Mouse Phenotypes related to Appendix Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 CDX2 GNAS HRAS KRAS MUC2

Drugs & Therapeutics for Appendix Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Follow up by US Following Hospitalization With Periappendicular Abscess Refusing to be Operated on Within a Few Weeks. Unknown status NCT01795560

Search NIH Clinical Center for Appendix Disease

Genetic Tests for Appendix Disease

Anatomical Context for Appendix Disease

MalaCards organs/tissues related to Appendix Disease:

41
Appendix, Lung, Colon, Ovary, Pancreas, Thymus, Small Intestine

The Foundational Model of Anatomy Ontology organs/tissues related to Appendix Disease:

19
The Appendix

Publications for Appendix Disease

Articles related to Appendix Disease:

# Title Authors Year
1
INTESTINAL CRISES SIMULATING CHRONIC APPENDIX DISEASE DIAGNOSED BY ROENTGEN RAY FINDINGS. ( 18737404 )
1917

Variations for Appendix Disease

Expression for Appendix Disease

Search GEO for disease gene expression data for Appendix Disease.

Pathways for Appendix Disease

Pathways related to Appendix Disease according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.75 GNAS HRAS KRAS KRT20
2
Show member pathways
12.74 CDX2 GNAS HRAS KRAS
3
Show member pathways
12.34 CDX2 HRAS KRAS MUC2
4
Show member pathways
12.17 GNAS HRAS KRAS
5
Show member pathways
12.13 GNAS HRAS KRAS
6
Show member pathways
11.85 GNAS HRAS KRAS
7
Show member pathways
11.76 GNAS HRAS KRAS
8
Show member pathways
11.67 HRAS KRAS MUC2 MUC6
9 11.49 GNAS HRAS KRAS
10 11.28 GNAS HRAS KRAS
11 11.23 HRAS KRAS
12 11.15 GNAS HRAS KRAS
13 11.09 HRAS KRAS
14 11.02 HRAS KRAS
15 11.01 HRAS KRAS
16
Show member pathways
10.99 HRAS KRAS
17
Show member pathways
10.93 HRAS KRAS
18 10.86 HRAS KRAS
19 10.82 HRAS KRAS
20 10.73 HRAS KRAS
21 10.58 GNAS HRAS KRAS
22 10.44 HRAS KRAS

GO Terms for Appendix Disease

Biological processes related to Appendix Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of long-term neuronal synaptic plasticity GO:0048169 9.26 HRAS KRAS
2 maintenance of gastrointestinal epithelium GO:0030277 9.16 MUC2 MUC6
3 response to isolation stress GO:0035900 8.96 HRAS KRAS
4 stimulatory C-type lectin receptor signaling pathway GO:0002223 8.92 HRAS KRAS MUC2 MUC6

Molecular functions related to Appendix Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 methyl-CpG binding GO:0008327 8.62 CDX2 ZBTB38

Sources for Appendix Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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