Appendix Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Appendix Disease

MalaCards integrated aliases for Appendix Disease:

Name: Appendix Disease ¹² ¹⁵

Disorder of Appendix ¹⁷

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the digestive system

Diseases of appendix

Other diseases of appendix

Other specified diseases of appendix

External Ids:

Disease Ontology ¹² DOID:60000

ICD10 ³⁴ K35-K38 K38.8

EFO ¹⁷ EFO_0009542

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Summaries for Appendix Disease

Disease Ontology : ¹² A gastrointestinal system disease that is located in the appendix.

MalaCards based summary : Appendix Disease, also known as disorder of appendix, is related to anus cancer and hidradenocarcinoma. An important gene associated with Appendix Disease is KRT7 (Keratin 7), and among its related pathways/superpathways are Circadian entrainment and fMLP Pathway. Affiliated tissues include appendix, colon and lung, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : ⁷⁷ The appendix (or vermiform appendix; also cecal [or caecal] appendix; vermix; or vermiform process) is a... more...

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Related Diseases for Appendix Disease

Diseases related to Appendix Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 192)

#	Related Disease	Score	Top Affiliating Genes
1	anus cancer	10.4	CDX2 KRT7
2	hidradenocarcinoma	10.4	CDX2 KRT7
3	sex cord-gonadal stromal tumor	10.4	GNAS KRT7
4	pregnancy adenoma	10.4	GNAS KRT7
5	ovarian clear cell carcinoma	10.4	KRAS KRT7
6	ovary neuroendocrine neoplasm	10.3	CDX2 KRT7
7	mucinous adenofibroma	10.3	CDX2 KRT7
8	large cell neuroendocrine carcinoma	10.3	KRT20 KRT7
9	anus adenocarcinoma	10.3	CDX2 KRT7
10	immune system organ benign neoplasm	10.3	KRT20 KRT7
11	thymus lipoma	10.3	KRT20 KRT7
12	ovarian brenner tumor	10.3	KRT20 KRT7
13	inverted papilloma	10.3	KRT20 KRT7
14	ovarian cystic teratoma	10.3	KRT20 KRT7
15	cervical adenosquamous carcinoma	10.3	KRT7 MUC6
16	epithelial predominant wilms' tumor	10.3	CDX2 KRT7
17	nasal cavity cancer	10.3	CDX2 KRT7
18	cystic basal cell carcinoma	10.3	KRT20 KRT7
19	seminal vesicle adenocarcinoma	10.3	KRT20 KRT7
20	transverse colon cancer	10.3	KRT20 KRT7
21	malignant syringoma	10.3	KRT20 KRT7
22	papillary transitional carcinoma	10.3	KRT20 KRT7
23	vaginal benign neoplasm	10.3	CDX2 KRT20
24	eyelid carcinoma	10.3	KRT20 KRT7
25	urachal adenocarcinoma	10.3	GNAS KRAS
26	vaginal adenoma	10.3	CDX2 KRT20
27	krukenberg carcinoma	10.3	KRT20 KRT7
28	vaginal tubulovillous adenoma	10.3	CDX2 KRT20
29	large intestine adenocarcinoma	10.3	KRT20 KRT7
30	linitis plastica	10.3	KRT20 KRT7
31	lung acinar adenocarcinoma	10.3	KRT20 KRT7
32	small cell carcinoma of the bladder	10.3	KRT20 KRT7
33	adenoid squamous cell carcinoma	10.2	KRT20 KRT7
34	mixed cell type cancer	10.2	HRAS KRT7
35	intratubular embryonal carcinoma	10.2	KRT20 KRT7
36	epithelial-myoepithelial carcinoma	10.2	HRAS KRT7
37	mucinous intrahepatic cholangiocarcinoma	10.2	CDX2 MUC6
38	vulval paget's disease	10.2	KRT20 KRT7
39	cervical polyp	10.2	CDX2 MUC6
40	meibomian cyst	10.2	KRT20 KRT7
41	multinodular goiter	10.2	GNAS HRAS
42	bladder lymphoma	10.2	KRT20 KRT7
43	papillary serous adenocarcinoma	10.2	KRT20 KRT7
44	costello syndrome	10.2	HRAS KRAS
45	pulmonic stenosis	10.2	HRAS KRAS
46	exanthem	10.2	HRAS KRAS
47	mucinous lung adenocarcinoma	10.2	HRAS KRAS
48	endocervical carcinoma	10.2	KRT7 MUC6
49	liver angiosarcoma	10.2	HRAS KRAS
50	adenosquamous lung carcinoma	10.2	HRAS KRAS

Graphical network of the top 20 diseases related to Appendix Disease:

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Symptoms & Phenotypes for Appendix Disease

GenomeRNAi Phenotypes related to Appendix Disease according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-2	9.47	HRAS KRAS MUC1
2	Decreased viability	GR00106-A-0	9.47	KRAS
3	Decreased viability	GR00221-A-1	9.47	HRAS KRAS
4	Decreased viability	GR00221-A-2	9.47	HRAS KRAS
5	Decreased viability	GR00221-A-3	9.47	HRAS
6	Decreased viability	GR00301-A	9.47	KRAS
7	Decreased viability	GR00381-A-1	9.47	KRAS
8	Decreased viability	GR00402-S-2	9.47	HRAS KRAS MUC1

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Drugs & Therapeutics for Appendix Disease

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Follow up by US Following Hospitalization With Periappendicular Abscess Refusing to be Operated on Within a Few Weeks.	Unknown status	NCT01795560

Search NIH Clinical Center for Appendix Disease

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Genetic Tests for Appendix Disease

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Anatomical Context for Appendix Disease

MalaCards organs/tissues related to Appendix Disease:

⁴²

Appendix, Colon, Lung, Ovary, Pancreas, Kidney, Thymus

The Foundational Model of Anatomy Ontology organs/tissues related to Appendix Disease:

²⁰

The Appendix

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Publications for Appendix Disease

Articles related to Appendix Disease:

#	Title	Authors	Year
1	INTESTINAL CRISES SIMULATING CHRONIC APPENDIX DISEASE DIAGNOSED BY ROENTGEN RAY FINDINGS. ( 18737404 )	Burnham MP...Crow LB	1917

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Genes for Appendix Disease

Genes related to Appendix Disease (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	KRT7	Keratin 7	Protein Coding	16.76	DISEASES inferred ¹⁵
2	CDX2	Caudal Type Homeobox 2	Protein Coding	16.38	DISEASES inferred ¹⁵
3	GNAS	GNAS Complex Locus	Protein Coding	16.15	DISEASES inferred ¹⁵
4	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	15.5	DISEASES inferred ¹⁵
5	KRT20	Keratin 20	Protein Coding	15.45	DISEASES inferred ¹⁵
6	MUC6	Mucin 6, Oligomeric Mucus/Gel-Forming	Protein Coding	15.27	DISEASES inferred ¹⁵
7	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	15.24	DISEASES inferred ¹⁵
8	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	14.87	DISEASES inferred ¹⁵
9	ZBTB38	Zinc Finger And BTB Domain Containing 38	Protein Coding	14.84	DISEASES inferred ¹⁵

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Variations for Appendix Disease

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Expression for Appendix Disease

Search GEO for disease gene expression data for Appendix Disease.

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Pathways for Appendix Disease

Pathways related to Appendix Disease according to GeneCards Suite gene sharing:

(show all 20)

#	Super pathways	Score	Top Affiliating Genes
1	Circadian entrainment ³⁸ Show member pathways Cholinergic synapse ³⁸ Dopaminergic synapse ³⁸ Estrogen signaling pathway ³⁸ Glutamatergic synapse ³⁸ Relaxin receptors ⁶⁷ Relaxin signaling pathway ³⁸ Synaptic Neurotransmission Pathways: Glutamatergic Excitation ⁶⁶	12.74	GNAS HRAS KRAS KRT20
2	fMLP Pathway ⁶⁵ Show member pathways Alpha-Adrenergic Signaling ⁶⁵ CCR3 Pathway in Eosinophils ⁶⁵ CXCR4 Pathway ⁶⁵ Huntington's Disease Pathway ⁶⁵ Internalin Pathway ⁶⁵ Signal transduction Activation of PKC via G-Protein coupled receptor ²³ VEGF and S-1P Signaling ⁶⁵	12.73	CDX2 GNAS HRAS KRAS
3	Phospholipase D signaling pathway ³⁸ Show member pathways Choline metabolism in cancer ³⁸	12.13	GNAS HRAS KRAS
4	Long-term potentiation ³⁸ Show member pathways Common Pathways Underlying Drug Addiction ¹ Dopamine D1-Like Receptor Family Signaling Pathways ⁶⁶	11.83	GNAS HRAS KRAS
5	Development EGFR signaling via small GTPases ²³ Show member pathways Development EGFR signaling via PIP3 ²³ Development PDGF signaling via MAPK cascades ²³ PDGF Pathway ¹	11.72	GNAS HRAS KRAS
6	CLEC7A (Dectin-1) signaling ⁶⁷ Show member pathways Alternative NF-kappaB pathway ¹ CLEC7A/inflammasome pathway ⁶⁷ C-type lectin receptors (CLRs) ⁶⁷	11.67	HRAS KRAS MUC1 MUC6
7	Serotonergic synapse ³⁸	11.49	GNAS HRAS KRAS
8	Gap junction ³⁸	11.28	GNAS HRAS KRAS
9	Vemurafenib Pathway, Pharmacodynamics ⁶²	11.22	HRAS KRAS
10	G-protein signaling_Cross-talk between Ras-family GTPases ²³	11.14	GNAS HRAS KRAS
11	BDNF-TrkB Signaling ¹	11.08	HRAS KRAS
12	Extracellular vesicle-mediated signaling in recipient cells ¹	11.01	HRAS KRAS
13	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities ¹	11	HRAS KRAS
14	Bisphosphonate Pathway, Pharmacodynamics ⁶² Show member pathways RalA downstream regulated genes ¹	10.97	HRAS KRAS
15	EGFR Transactivation by Gastrin ⁶⁷ Show member pathways EGFR-dependent Endothelin signaling events ¹ SHC-related events triggered by IGF1R ⁶⁷	10.91	HRAS KRAS
16	MNAR-PELP1 and Estrogen Receptor Interaction ⁶⁵	10.84	HRAS KRAS
17	CD209 (DC-SIGN) signaling ⁶⁷	10.8	HRAS KRAS
18	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling ¹	10.71	HRAS KRAS
19	Long-term depression ³⁸	10.58	GNAS HRAS KRAS
20	p38MAPK events ⁶⁷	10.44	HRAS KRAS

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GO Terms for Appendix Disease

Biological processes related to Appendix Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of long-term neuronal synaptic plasticity	GO:0048169	9.16	HRAS KRAS
2	response to isolation stress	GO:0035900	8.96	HRAS KRAS
3	stimulatory C-type lectin receptor signaling pathway	GO:0002223	8.92	HRAS KRAS MUC1 MUC6

Molecular functions related to Appendix Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	methyl-CpG binding	GO:0008327	8.62	CDX2 ZBTB38

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Sources for Appendix Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia