MCID: APP018
MIFTS: 28

Appendix Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Appendix Disease

MalaCards integrated aliases for Appendix Disease:

Name: Appendix Disease 12 15
Disorder of Appendix 17

Classifications:



External Ids:

Disease Ontology 12 DOID:60000

Summaries for Appendix Disease

Disease Ontology : 12 A gastrointestinal system disease that is located in the appendix.

MalaCards based summary : Appendix Disease, also known as disorder of appendix, is related to bladder signet ring cell adenocarcinoma and ovary neuroendocrine neoplasm. An important gene associated with Appendix Disease is KRT7 (Keratin 7), and among its related pathways/superpathways are Gastric cancer and Development ERBB-family signaling. Affiliated tissues include appendix.

Related Diseases for Appendix Disease

Diseases related to Appendix Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 356)
# Related Disease Score Top Affiliating Genes
1 bladder signet ring cell adenocarcinoma 10.6 KRT7 CDX2
2 ovary neuroendocrine neoplasm 10.6 KRT7 CDX2
3 anal canal paget's disease 10.6 KRT7 CDX2
4 adenosquamous colon carcinoma 10.5 KRT7 CDX2
5 anus adenocarcinoma 10.5 KRT7 CDX2
6 rectum neuroendocrine neoplasm 10.5 KRT7 CDX2
7 cutaneous mucoepidermoid carcinoma 10.5 KRT7 CEACAM5
8 pancreatic serous cystadenocarcinoma 10.5 KRT7 KRT20
9 intrahepatic bile duct adenoma 10.5 KRT7 KRT20
10 vulval paget's disease 10.5 KRT7 CEACAM5
11 sigmoid neoplasm 10.5 KRT7 CEACAM5
12 nephrogenic adenoma of urinary bladder 10.5 KRT7 KRT20
13 eccrine adenocarcinoma 10.5 KRT7 CEACAM5
14 ovarian large-cell neuroendocrine carcinoma 10.5 KRT7 KRT20
15 renal pelvis adenocarcinoma 10.5 KRT7 CEACAM5
16 external ear carcinoma 10.5 KRT7 CEACAM5
17 atrophic vulva 10.5 KRT7 KRT20
18 small cell carcinoma of the bladder 10.5 KRT7 KRT20
19 urinary bladder small cell neuroendocrine carcinoma 10.5 KRT7 KRT20
20 eccrine papillary adenocarcinoma 10.5 KRT7 CEACAM5
21 eyelid carcinoma 10.5 KRT7 KRT20
22 clear cell hidradenoma 10.5 KRT7 CEACAM5
23 ovarian brenner tumor 10.5 KRT7 KRT20
24 hidrocystoma 10.5 KRT7 CEACAM5
25 liver sarcoma 10.5 KRT7 CEACAM5
26 benign mesothelioma 10.5 KRT7 CEACAM5
27 pericardium cancer 10.5 KRT7 CEACAM5
28 immature teratoma of ovary 10.5 KRAS CEACAM5
29 apocrine adenocarcinoma 10.5 MUC1 KRT7
30 eccrine sweat gland neoplasm 10.5 KRT7 CEACAM5
31 nephrogenic adenoma of the urethra 10.5 KRT7 KRT20
32 cystadenofibroma 10.5 MUC1 KRT7
33 warthin tumor 10.5 KRT7 CEACAM5
34 scrotum paget's disease 10.4 MUC1 KRT7
35 colon neuroendocrine neoplasm 10.4 CEACAM5 CDX2
36 trachea carcinoma in situ 10.4 KRAS HRAS
37 gallbladder signet ring cell adenocarcinoma 10.4 MUC1 KRT7
38 pulmonary artery leiomyosarcoma 10.4 KRT7 KRT20
39 nephrogenic adenoma 10.4 MUC1 KRT7
40 anal canal adenocarcinoma 10.4 MUC5AC KRT7 CDX2
41 ureter adenocarcinoma 10.4 KRT7 CEACAM5 CDX2
42 bladder lateral wall cancer 10.4 KRT7 KRT20
43 mucinous adenofibroma 10.4 KRT7 CEACAM5 CDX2
44 ampulla of vater neoplasm 10.4 KRAS HRAS
45 anal paget's disease 10.4 KRT7 CEACAM5 CDX2
46 periampullary adenoma 10.4 KRAS HRAS
47 pancreatic serous cystadenoma 10.4 MUC6 CEACAM5
48 gastric signet ring cell adenocarcinoma 10.4 KRT7 KRT20 CDX2
49 esophageal adenosquamous carcinoma 10.4 KRT7 CEACAM5 CDX2
50 acneiform dermatitis 10.4 KRAS HRAS

Graphical network of the top 20 diseases related to Appendix Disease:



Diseases related to Appendix Disease

Symptoms & Phenotypes for Appendix Disease

Drugs & Therapeutics for Appendix Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 US Follow-up After Appendicitis Attack. Unknown status NCT01795560

Search NIH Clinical Center for Appendix Disease

Genetic Tests for Appendix Disease

Anatomical Context for Appendix Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Appendix Disease:

19
Appendix

MalaCards organs/tissues related to Appendix Disease:

40
Appendix

Publications for Appendix Disease

Articles related to Appendix Disease:

# Title Authors PMID Year
1
Post-transplant Lymphoproliferative Disorder of Appendix Mimicking Acute Appendicitis: A Case Report. 61
31371216 2019
2
Decreased Toll-like receptor-2 messenger ribonucleic acid and increased Toll-like receptor-4 in the tubal epithelium next to the infiltrated trophoblasts during tubal pregnancy. 61
27793374 2017
3
Transumbilical single-incision laparoscopic combined cholecystectomy and appendectomy: a retrospective comparative study. 61
25244670 2014
4
Locally elevated leukemia inhibitory factor in the inflamed fallopian tube resembles that found in tubal pregnancy. 61
18468598 2009
5
INTESTINAL CRISES SIMULATING CHRONIC APPENDIX DISEASE DIAGNOSED BY ROENTGEN RAY FINDINGS. 61
18737404 1917

Variations for Appendix Disease

Expression for Appendix Disease

Search GEO for disease gene expression data for Appendix Disease.

Pathways for Appendix Disease

Pathways related to Appendix Disease according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.43 TP53 REG4 KRAS HRAS CDX2
2
Show member pathways
12.28 TP53 MUC1 KRAS HRAS
3 11.82 TP53 KRAS HRAS
4
Show member pathways
11.82 MUC6 MUC5B MUC5AC MUC1
5 11.81 TP53 KRAS HRAS
6 11.78 KRAS HRAS GNAS
7 11.77 TP53 KRAS HRAS
8 11.75 TP53 KRAS HRAS
9 11.62 KRAS HRAS GNAS
10
Show member pathways
11.62 MUC6 MUC5B MUC5AC MUC1
11
Show member pathways
11.51 MUC6 MUC5B MUC5AC MUC1 KRAS HRAS
12 11.5 TP53 KRAS HRAS
13 11.45 TP53 KRAS HRAS
14 11.39 TP53 KRAS HRAS
15
Show member pathways
11.29 MUC6 MUC5B MUC5AC MUC1
16 11.28 KRAS HRAS GNAS
17 10.62 KRAS HRAS

GO Terms for Appendix Disease

Cellular components related to Appendix Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.92 MUC6 MUC5B MUC5AC MUC1

Biological processes related to Appendix Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras protein signal transduction GO:0007265 9.5 TP53 KRAS HRAS
2 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.37 TP53 MUC1
3 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 9.26 TP53 MUC1
4 O-glycan processing GO:0016266 9.26 MUC6 MUC5B MUC5AC MUC1
5 response to isolation stress GO:0035900 9.16 KRAS HRAS
6 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.1 MUC6 MUC5B MUC5AC MUC1 KRAS HRAS

Sources for Appendix Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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