MCID: APP018
MIFTS: 31

Appendix Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Appendix Disease

MalaCards integrated aliases for Appendix Disease:

Name: Appendix Disease 12 15
Disorder of Appendix 17

Classifications:



External Ids:

Disease Ontology 12 DOID:60000

Summaries for Appendix Disease

Disease Ontology : 12 A gastrointestinal system disease that is located in the appendix.

MalaCards based summary : Appendix Disease, also known as disorder of appendix, is related to ovary neuroendocrine neoplasm and leukoplakia of penis. An important gene associated with Appendix Disease is KRT7 (Keratin 7), and among its related pathways/superpathways are Pathways in cancer and VEGF Signaling. Affiliated tissues include appendix and colon, and related phenotypes are digestive/alimentary and neoplasm

Wikipedia : 74 The appendix (or vermiform appendix; also cecal [or caecal] appendix; vermix; or vermiform process) is a... more...

Related Diseases for Appendix Disease

Diseases related to Appendix Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 414)
# Related Disease Score Top Affiliating Genes
1 ovary neuroendocrine neoplasm 10.6 KRT7 CDX2
2 leukoplakia of penis 10.6 KRT7 CEACAM5
3 anal canal paget's disease 10.6 KRT7 CDX2
4 adenosquamous colon carcinoma 10.6 KRT7 CDX2
5 anus adenocarcinoma 10.6 KRT7 CDX2
6 bartholin's gland carcinoma 10.5 KRT7 CDX2
7 laryngeal mucoepidermoid carcinoma 10.5 CEACAM5 CDX2
8 malignant acrospiroma 10.5 KRT7 CEACAM5
9 bartholin's gland disease 10.5 KRT7 CDX2
10 rectum neuroendocrine neoplasm 10.5 KRT7 CDX2
11 cutaneous mucoepidermoid carcinoma 10.5 KRT7 CEACAM5
12 vulval paget's disease 10.5 KRT7 CEACAM5
13 nephrogenic adenoma of urinary bladder 10.5 KRT7 KRT20
14 intrahepatic bile duct adenoma 10.5 KRT7 KRT20
15 eccrine adenocarcinoma 10.5 KRT7 CEACAM5
16 renal pelvis adenocarcinoma 10.5 KRT7 CEACAM5
17 atrophic vulva 10.5 KRT7 KRT20
18 external ear carcinoma 10.5 KRT7 CEACAM5
19 ovarian primitive germ cell tumor 10.5 KRT7 CDX2
20 small cell carcinoma of the bladder 10.5 KRT7 KRT20
21 adenoid basal cell carcinoma 10.5 KRT7 CEACAM5
22 apocrine adenoma 10.5 KRT7 KRAS
23 scrotum paget's disease 10.5 MUC1 KRT7
24 squamous cell bile duct carcinoma 10.5 KRT7 CEACAM5
25 urinary bladder small cell neuroendocrine carcinoma 10.5 KRT7 KRT20
26 eyelid carcinoma 10.5 KRT7 KRT20
27 fibroepithelial basal cell carcinoma 10.5 KRT20 CEACAM5
28 cervical mucinous adenocarcinoma 10.5 MUC6 KRT7
29 gallbladder signet ring cell adenocarcinoma 10.5 MUC1 KRT7
30 clear cell hidradenoma 10.5 KRT7 CEACAM5
31 ovarian large-cell neuroendocrine carcinoma 10.5 KRT7 KRT20
32 hidrocystoma 10.5 KRT7 CEACAM5
33 liver sarcoma 10.5 KRT7 CEACAM5
34 meibomian cyst 10.5 KRT7 KRT20
35 immature teratoma of ovary 10.4 KRAS CEACAM5
36 trachea carcinoma in situ 10.4 KRAS HRAS
37 cobblestone retinal degeneration 10.4 KRAS HRAS
38 anal gland adenocarcinoma 10.4 MUC5AC KRT7 CDX2
39 ovarian brenner tumor 10.4 KRT7 KRT20
40 pancreatic serous cystadenoma 10.4 MUC6 CEACAM5
41 vulvar eccrine porocarcinoma 10.4 MUC1 CEACAM5
42 ureter adenocarcinoma 10.4 KRT7 CEACAM5 CDX2
43 anal canal adenocarcinoma 10.4 MUC5AC KRT7 CDX2
44 middle ear adenoma 10.4 MUC1 KRT7
45 mucinous adenofibroma 10.4 KRT7 CEACAM5 CDX2
46 bile acid synthesis defect, congenital, 5 10.4 KRAS CEACAM5
47 anal paget's disease 10.4 KRT7 CEACAM5 CDX2
48 warthin tumor 10.4 KRT7 CEACAM5
49 lipid-rich breast carcinoma 10.4 MUC1 CEACAM5
50 gastric tubular adenocarcinoma 10.4 MUC6 MUC5AC

Graphical network of the top 20 diseases related to Appendix Disease:



Diseases related to Appendix Disease

Symptoms & Phenotypes for Appendix Disease

MGI Mouse Phenotypes related to Appendix Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 CDX2 HRAS KRAS MUC5AC SATB2 SMAD4
2 neoplasm MP:0002006 9.1 CDX2 GNAS HRAS KRAS SMAD4 TP53

Drugs & Therapeutics for Appendix Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 US Follow-up After Appendicitis Attack. Unknown status NCT01795560

Search NIH Clinical Center for Appendix Disease

Genetic Tests for Appendix Disease

Anatomical Context for Appendix Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Appendix Disease:

19
Appendix

MalaCards organs/tissues related to Appendix Disease:

40
Appendix, Colon

Publications for Appendix Disease

Articles related to Appendix Disease:

# Title Authors PMID Year
1
Post-transplant Lymphoproliferative Disorder of Appendix Mimicking Acute Appendicitis: A Case Report. 61
31371216 2019
2
Decreased Toll-like receptor-2 messenger ribonucleic acid and increased Toll-like receptor-4 in the tubal epithelium next to the infiltrated trophoblasts during tubal pregnancy. 61
27793374 2017
3
Transumbilical single-incision laparoscopic combined cholecystectomy and appendectomy: a retrospective comparative study. 61
25244670 2014
4
Locally elevated leukemia inhibitory factor in the inflamed fallopian tube resembles that found in tubal pregnancy. 61
18468598 2009
5
INTESTINAL CRISES SIMULATING CHRONIC APPENDIX DISEASE DIAGNOSED BY ROENTGEN RAY FINDINGS. 61
18737404 1917

Variations for Appendix Disease

Expression for Appendix Disease

Search GEO for disease gene expression data for Appendix Disease.

Pathways for Appendix Disease

Pathways related to Appendix Disease according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1 12.67 TP53 SMAD4 KRAS HRAS GNAS
2
Show member pathways
12.18 TP53 SMAD4 MUC1 KRAS HRAS
3 12.14 TP53 SMAD4 KRAS HRAS
4
Show member pathways
12.1 TP53 SMAD4 REG4 KRAS HRAS CDX2
5
Show member pathways
12.02 MUC6 MUC5B MUC5AC MUC1
6 11.95 TP53 SMAD4 KRAS GNAS
7
Show member pathways
11.87 MUC6 MUC5B MUC5AC MUC1
8 11.82 TP53 KRAS HRAS
9
Show member pathways
11.8 KRAS HRAS GNAS
10 11.79 TP53 SMAD4 HRAS
11 11.75 SMAD4 KRAS HRAS
12 11.68 KRAS HRAS GNAS
13 11.62 TP53 SMAD4 KRAS HRAS
14 11.58 TP53 KRAS HRAS
15 11.55 TP53 KRAS HRAS
16 11.52 TP53 KRAS HRAS
17
Show member pathways
11.51 MUC6 MUC5B MUC5AC MUC1 KRAS HRAS
18
Show member pathways
11.49 MUC6 MUC5B MUC5AC MUC1
19 11.43 KRAS HRAS GNAS
20 11.02 SMAD4 KRAS HRAS
21 10.68 KRAS HRAS

GO Terms for Appendix Disease

Cellular components related to Appendix Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.92 MUC6 MUC5B MUC5AC MUC1

Biological processes related to Appendix Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras protein signal transduction GO:0007265 9.5 TP53 KRAS HRAS
2 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.37 TP53 MUC1
3 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 9.26 TP53 MUC1
4 O-glycan processing GO:0016266 9.26 MUC6 MUC5B MUC5AC MUC1
5 response to isolation stress GO:0035900 9.16 KRAS HRAS
6 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.1 MUC6 MUC5B MUC5AC MUC1 KRAS HRAS

Molecular functions related to Appendix Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.02 TP53 SMAD4 SATB2 MUC1 CDX2

Sources for Appendix Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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