Appendix Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Appendix Disease

MalaCards integrated aliases for Appendix Disease:

Name: Appendix Disease ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the digestive system

Diseases of appendix

Other diseases of appendix

Other specified diseases of appendix

External Ids:

Disease Ontology ¹² DOID:60000

ICD10 ³³ K35-K38 K38.8

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Summaries for Appendix Disease

Disease Ontology : ¹² A gastrointestinal system disease that is located in the appendix.

MalaCards based summary : Appendix Disease is related to suppurative cholangitis and sex cord-gonadal stromal tumor. An important gene associated with Appendix Disease is MUC2 (Mucin 2, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are Circadian entrainment and fMLP Pathway. Affiliated tissues include appendix, lung and colon, and related phenotype is neoplasm.

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Related Diseases for Appendix Disease

Diseases related to Appendix Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)

#	Related Disease	Score	Top Affiliating Genes
1	suppurative cholangitis	10.2	CDX2 MUC2
2	sex cord-gonadal stromal tumor	10.2	GNAS KRT7
3	bile duct mucoepidermoid carcinoma	10.2	KRT7 MUC2
4	ovary neuroendocrine neoplasm	10.2	CDX2 KRT7
5	ovarian clear cell carcinoma	10.2	KRAS KRT7
6	mucinous adenofibroma	10.2	CDX2 KRT7
7	papillary adenocarcinoma	10.2	KRT7 MUC2
8	anus adenocarcinoma	10.2	CDX2 KRT7
9	chronic cholangitis	10.2	CDX2 MUC2
10	epithelial predominant wilms' tumor	10.2	CDX2 KRT7
11	large cell neuroendocrine carcinoma	10.2	KRT20 KRT7
12	ovarian brenner tumor	10.2	KRT20 KRT7
13	inverted papilloma	10.2	KRT20 KRT7
14	mammary paget's disease	10.2	KRT20 KRT7
15	dysgerminoma	10.2	KRT20 KRT7
16	clear cell adenocarcinoma	10.2	KRT20 KRT7
17	nasal cavity cancer	10.2	CDX2 KRT7
18	mucinous ovarian cystadenoma	10.2	CDX2 KRT7
19	polyposis, skin pigmentation, alopecia, and fingernail changes	10.2	CDX2 MUC2
20	cystic basal cell carcinoma	10.2	KRT20 KRT7
21	tn polyagglutination syndrome	10.2	MUC2 MUC6
22	colorectal cancer 1	10.2	MUC2 MUC6
23	seminal vesicle adenocarcinoma	10.2	KRT20 KRT7
24	epstein-barr virus-associated gastric carcinoma	10.2	MUC2 MUC6
25	transverse colon cancer	10.2	KRT20 KRT7
26	malignant syringoma	10.1	KRT20 KRT7
27	urachal adenocarcinoma	10.1	GNAS KRAS
28	papillary transitional carcinoma	10.1	KRT20 KRT7
29	vaginal benign neoplasm	10.1	CDX2 KRT20
30	krukenberg carcinoma	10.1	KRT20 KRT7
31	vaginal adenoma	10.1	CDX2 KRT20
32	vaginal tubulovillous adenoma	10.1	CDX2 KRT20
33	large intestine adenocarcinoma	10.1	KRT20 KRT7
34	linitis plastica	10.1	KRT20 KRT7
35	lung acinar adenocarcinoma	10.1	KRT20 KRT7
36	small cell carcinoma of the bladder	10.1	KRT20 KRT7
37	adenoid squamous cell carcinoma	10.1	KRT20 KRT7
38	intratubular embryonal carcinoma	10.1	KRT20 KRT7
39	vulval paget's disease	10.1	KRT20 KRT7
40	bile duct adenoma	10.1	KRT20 KRT7
41	alveoli adenoma	10.1	KRAS KRT7
42	meibomian cyst	10.1	KRT20 KRT7
43	bladder lymphoma	10.1	KRT20 KRT7
44	papillary serous adenocarcinoma	10.1	KRT20 KRT7
45	small intestine adenocarcinoma	10.1	MUC2 MUC6
46	medulloepithelioma	10.1	KRT20 KRT7
47	glycogen-rich clear cell breast carcinoma	10.1	KRT20 KRT7
48	microinvasive gastric cancer	10.1	CDX2 MUC2
49	solid adenocarcinoma with mucin production	10.1	KRT7 MUC6
50	chronic ethmoiditis	10.1	MUC2 MUC6

Graphical network of the top 20 diseases related to Appendix Disease:

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Symptoms & Phenotypes for Appendix Disease

MGI Mouse Phenotypes related to Appendix Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.02	CDX2 GNAS HRAS KRAS MUC2

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Drugs & Therapeutics for Appendix Disease

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Follow up by US Following Hospitalization With Periappendicular Abscess Refusing to be Operated on Within a Few Weeks.	Unknown status	NCT01795560

Search NIH Clinical Center for Appendix Disease

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Genetic Tests for Appendix Disease

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Anatomical Context for Appendix Disease

MalaCards organs/tissues related to Appendix Disease:

⁴¹

Appendix, Lung, Colon, Ovary, Pancreas, Thymus, Small Intestine

The Foundational Model of Anatomy Ontology organs/tissues related to Appendix Disease:

¹⁹

The Appendix

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Publications for Appendix Disease

Articles related to Appendix Disease:

#	Title	Authors	Year
1	INTESTINAL CRISES SIMULATING CHRONIC APPENDIX DISEASE DIAGNOSED BY ROENTGEN RAY FINDINGS. ( 18737404 )	Burnham MP...Crow LB	1917

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Genes for Appendix Disease

Genes related to Appendix Disease (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MUC2	Mucin 2, Oligomeric Mucus/Gel-Forming	Protein Coding	17.11	DISEASES inferred ¹⁵
2	KRT7	Keratin 7	Protein Coding	16.68	DISEASES inferred ¹⁵
3	CDX2	Caudal Type Homeobox 2	Protein Coding	16.27	DISEASES inferred ¹⁵
4	GNAS	GNAS Complex Locus	Protein Coding	15.99	DISEASES inferred ¹⁵
5	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	15.4	DISEASES inferred ¹⁵
6	KRT20	Keratin 20	Protein Coding	15.4	DISEASES inferred ¹⁵
7	MUC6	Mucin 6, Oligomeric Mucus/Gel-Forming	Protein Coding	15.24	DISEASES inferred ¹⁵
8	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	15.14	DISEASES inferred ¹⁵
9	ZBTB38	Zinc Finger And BTB Domain Containing 38	Protein Coding	14.89	DISEASES inferred ¹⁵

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Variations for Appendix Disease

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Expression for Appendix Disease

Search GEO for disease gene expression data for Appendix Disease.

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Pathways for Appendix Disease

Pathways related to Appendix Disease according to GeneCards Suite gene sharing:

(show all 22)

#	Super pathways	Score	Top Affiliating Genes
1	Circadian entrainment ³⁷ Show member pathways Cholinergic synapse ³⁷ Dopaminergic synapse ³⁷ Estrogen signaling pathway ³⁷ Glutamatergic synapse ³⁷ Relaxin receptors ⁶⁶ Relaxin signaling pathway ³⁷ Synaptic Neurotransmission Pathways: Glutamatergic Excitation ⁶⁵	12.75	GNAS HRAS KRAS KRT20
2	fMLP Pathway ⁶⁴ Show member pathways Alpha-Adrenergic Signaling ⁶⁴ CCR3 Pathway in Eosinophils ⁶⁴ CXCR4 Pathway ⁶⁴ Huntington's Disease Pathway ⁶⁴ Internalin Pathway ⁶⁴ Signal transduction Activation of PKC via G-Protein coupled receptor ²² VEGF and S-1P Signaling ⁶⁴	12.74	CDX2 GNAS HRAS KRAS
3	Gastric cancer ³⁷ Show member pathways Breast cancer ³⁷ Hepatocellular carcinoma ³⁷	12.34	CDX2 HRAS KRAS MUC2
4	Cushing syndrome ³⁷ Show member pathways Melanogenesis ³⁷	12.17	GNAS HRAS KRAS
5	Phospholipase D signaling pathway ³⁷ Show member pathways Choline metabolism in cancer ³⁷	12.13	GNAS HRAS KRAS
6	Long-term potentiation ³⁷ Show member pathways Common Pathways Underlying Drug Addiction ¹ Dopamine D1-Like Receptor Family Signaling Pathways ⁶⁵	11.85	GNAS HRAS KRAS
7	Development EGFR signaling via small GTPases ²² Show member pathways Development EGFR signaling via PIP3 ²² Development PDGF signaling via MAPK cascades ²² PDGF Pathway ¹	11.76	GNAS HRAS KRAS
8	CLEC7A (Dectin-1) signaling ⁶⁶ Show member pathways Alternative NF-kappaB pathway ¹ CLEC7A/inflammasome pathway ⁶⁶ C-type lectin receptors (CLRs) ⁶⁶	11.67	HRAS KRAS MUC2 MUC6
9	Serotonergic synapse ³⁷	11.49	GNAS HRAS KRAS
10	Gap junction ³⁷	11.28	GNAS HRAS KRAS
11	Vemurafenib Pathway, Pharmacodynamics ⁶¹	11.23	HRAS KRAS
12	G-protein signaling_Cross-talk between Ras-family GTPases ²²	11.15	GNAS HRAS KRAS
13	BDNF-TrkB Signaling ¹	11.09	HRAS KRAS
14	Extracellular vesicle-mediated signaling in recipient cells ¹	11.02	HRAS KRAS
15	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities ¹	11.01	HRAS KRAS
16	Bisphosphonate Pathway, Pharmacodynamics ⁶¹ Show member pathways RalA downstream regulated genes ¹	10.99	HRAS KRAS
17	EGFR Transactivation by Gastrin ⁶⁶ Show member pathways EGFR-dependent Endothelin signaling events ¹ SHC-related events triggered by IGF1R ⁶⁶	10.93	HRAS KRAS
18	MNAR-PELP1 and Estrogen Receptor Interaction ⁶⁴	10.86	HRAS KRAS
19	CD209 (DC-SIGN) signaling ⁶⁶	10.82	HRAS KRAS
20	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling ¹	10.73	HRAS KRAS
21	Long-term depression ³⁷	10.58	GNAS HRAS KRAS
22	p38MAPK events ⁶⁶	10.44	HRAS KRAS

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GO Terms for Appendix Disease

Biological processes related to Appendix Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of long-term neuronal synaptic plasticity	GO:0048169	9.26	HRAS KRAS
2	maintenance of gastrointestinal epithelium	GO:0030277	9.16	MUC2 MUC6
3	response to isolation stress	GO:0035900	8.96	HRAS KRAS
4	stimulatory C-type lectin receptor signaling pathway	GO:0002223	8.92	HRAS KRAS MUC2 MUC6

Molecular functions related to Appendix Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	methyl-CpG binding	GO:0008327	8.62	CDX2 ZBTB38

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Sources for Appendix Disease

¹ BioSystems

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³ CDC

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⁷⁶ Wikipedia