MCID: APP018
MIFTS: 29

Appendix Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Appendix Disease

MalaCards integrated aliases for Appendix Disease:

Name: Appendix Disease 12 15
Disorder of Appendix 17

Classifications:



External Ids:

Disease Ontology 12 DOID:60000

Summaries for Appendix Disease

Disease Ontology : 12 A gastrointestinal system disease that is located in the appendix.

MalaCards based summary : Appendix Disease, also known as disorder of appendix, is related to ovary neuroendocrine neoplasm and anus adenocarcinoma. An important gene associated with Appendix Disease is KRT7 (Keratin 7), and among its related pathways/superpathways are Long-term potentiation and Development EGFR signaling via small GTPases. Affiliated tissues include appendix, colon and appendix, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 75 The appendix (or vermiform appendix; also cecal [or caecal] appendix; vermix; or vermiform process) is a... more...

Related Diseases for Appendix Disease

Diseases related to Appendix Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 ovary neuroendocrine neoplasm 10.6 KRT7 CDX2
2 anus adenocarcinoma 10.6 KRT7 CDX2
3 mucinous adenofibroma 10.6 KRT7 CDX2
4 epithelial predominant wilms' tumor 10.6 KRT7 CDX2
5 nasal cavity cancer 10.6 KRT7 CDX2
6 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 10.5 SATB2 GNAS
7 urachal adenocarcinoma 10.5 KRAS GNAS
8 mucinous intrahepatic cholangiocarcinoma 10.5 MUC6 CDX2
9 pregnancy adenoma 10.5 KRT7 GNAS
10 cervical polyp 10.5 MUC6 CDX2
11 alveoli adenoma 10.5 KRT7 KRAS
12 endocervical carcinoma 10.5 MUC6 KRT7
13 cystic basal cell carcinoma 10.4 KRT7 KRT20
14 malignant syringoma 10.4 KRT7 KRT20
15 transverse colon cancer 10.4 KRT7 KRT20
16 seminal vesicle adenocarcinoma 10.4 KRT7 KRT20
17 krukenberg carcinoma 10.4 KRT7 KRT20
18 hidradenocarcinoma 10.4 KRT7 CDX2
19 eyelid carcinoma 10.4 KRT7 KRT20
20 papillary transitional carcinoma 10.4 KRT7 KRT20
21 small cell carcinoma of the bladder 10.4 KRT7 KRT20
22 lung acinar adenocarcinoma 10.4 KRT7 KRT20
23 vaginal tubulovillous adenoma 10.4 KRT20 CDX2
24 linitis plastica 10.4 KRT7 KRT20
25 vaginal adenoma 10.4 KRT20 CDX2
26 vaginal benign neoplasm 10.4 KRT20 CDX2
27 large intestine adenocarcinoma 10.4 KRT7 KRT20
28 intratubular embryonal carcinoma 10.4 KRT7 KRT20
29 adenoid squamous cell carcinoma 10.4 KRT7 KRT20
30 anus cancer 10.4 KRT7 CDX2
31 vulval paget's disease 10.4 KRT7 KRT20
32 meibomian cyst 10.4 KRT7 KRT20
33 superior mesenteric artery syndrome 10.4 MUC6 CDX2
34 papillary serous adenocarcinoma 10.4 KRT7 KRT20
35 bladder lymphoma 10.4 KRT7 KRT20
36 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.4 SATB2 KRAS
37 juxtacortical osteosarcoma 10.4 SATB2 GNAS
38 glycogen-rich clear cell breast carcinoma 10.4 KRT7 KRT20
39 medulloepithelioma 10.4 KRT7 KRT20
40 renal pelvis carcinoma 10.4 KRT7 KRT20
41 cervical adenosquamous carcinoma 10.3 MUC6 KRT7
42 infiltrative basal cell carcinoma 10.3 KRT7 KRT20
43 eccrine sweat gland neoplasm 10.3 KRT7 KRT20
44 thymus lipoma 10.3 KRT7 KRT20
45 ovarian cystic teratoma 10.3 KRT7 KRT20
46 mature teratoma 10.3 ZBTB38 KRAS
47 immune system organ benign neoplasm 10.3 KRT7 KRT20
48 prostate squamous cell carcinoma 10.3 KRT7 HRAS
49 sigmoid neoplasm 10.3 KRAS HRAS
50 paronychia 10.2 KRAS HRAS

Graphical network of the top 20 diseases related to Appendix Disease:



Diseases related to Appendix Disease

Symptoms & Phenotypes for Appendix Disease

GenomeRNAi Phenotypes related to Appendix Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.47 HRAS KRAS MUC1
2 Decreased viability GR00106-A-0 9.47 KRAS
3 Decreased viability GR00221-A-1 9.47 HRAS KRAS
4 Decreased viability GR00221-A-2 9.47 HRAS KRAS
5 Decreased viability GR00221-A-3 9.47 HRAS
6 Decreased viability GR00301-A 9.47 KRAS
7 Decreased viability GR00381-A-1 9.47 KRAS
8 Decreased viability GR00402-S-2 9.47 HRAS KRAS MUC1

Drugs & Therapeutics for Appendix Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 US Follow-up After Appendicitis Attack. Unknown status NCT01795560

Search NIH Clinical Center for Appendix Disease

Genetic Tests for Appendix Disease

Anatomical Context for Appendix Disease

MalaCards organs/tissues related to Appendix Disease:

41
Appendix, Colon

The Foundational Model of Anatomy Ontology organs/tissues related to Appendix Disease:

19
Appendix

Publications for Appendix Disease

Articles related to Appendix Disease:

# Title Authors PMID Year
1
Post-transplant Lymphoproliferative Disorder of Appendix Mimicking Acute Appendicitis: A Case Report. 38
31371216 2019
2
Decreased Toll-like receptor-2 messenger ribonucleic acid and increased Toll-like receptor-4 in the tubal epithelium next to the infiltrated trophoblasts during tubal pregnancy. 38
27793374 2017
3
Transumbilical single-incision laparoscopic combined cholecystectomy and appendectomy: a retrospective comparative study. 38
25244670 2014
4
Locally elevated leukemia inhibitory factor in the inflamed fallopian tube resembles that found in tubal pregnancy. 38
18468598 2009
5
INTESTINAL CRISES SIMULATING CHRONIC APPENDIX DISEASE DIAGNOSED BY ROENTGEN RAY FINDINGS. 38
18737404 1917

Variations for Appendix Disease

Expression for Appendix Disease

Search GEO for disease gene expression data for Appendix Disease.

Pathways for Appendix Disease

Pathways related to Appendix Disease according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.83 KRAS HRAS GNAS
2
Show member pathways
11.72 KRAS HRAS GNAS
3
Show member pathways
11.67 MUC6 MUC1 KRAS HRAS
4 11.49 KRAS HRAS GNAS
5 11.28 KRAS HRAS GNAS
6 11.07 KRAS HRAS
7 11.01 KRAS HRAS
8 11 KRAS HRAS
9
Show member pathways
10.97 KRAS HRAS
10
Show member pathways
10.91 KRAS HRAS
11 10.84 KRAS HRAS
12 10.8 KRAS HRAS
13 10.71 KRAS HRAS
14 10.58 KRAS HRAS GNAS
15 10.44 KRAS HRAS

GO Terms for Appendix Disease

Biological processes related to Appendix Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of long-term neuronal synaptic plasticity GO:0048169 9.16 KRAS HRAS
2 response to isolation stress GO:0035900 8.96 KRAS HRAS
3 stimulatory C-type lectin receptor signaling pathway GO:0002223 8.92 MUC6 MUC1 KRAS HRAS

Molecular functions related to Appendix Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 methyl-CpG binding GO:0008327 8.62 ZBTB38 CDX2

Sources for Appendix Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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