MCID: APP018
MIFTS: 32

Appendix Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Appendix Disease

MalaCards integrated aliases for Appendix Disease:

Name: Appendix Disease 12 15
Disorder of Appendix 17

Classifications:



External Ids:

Disease Ontology 12 DOID:60000
ICD10 34 K35-K38 K38.8

Summaries for Appendix Disease

Disease Ontology : 12 A gastrointestinal system disease that is located in the appendix.

MalaCards based summary : Appendix Disease, also known as disorder of appendix, is related to anus cancer and hidradenocarcinoma. An important gene associated with Appendix Disease is KRT7 (Keratin 7), and among its related pathways/superpathways are Circadian entrainment and fMLP Pathway. Affiliated tissues include appendix, colon and lung, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 77 The appendix (or vermiform appendix; also cecal [or caecal] appendix; vermix; or vermiform process) is a... more...

Related Diseases for Appendix Disease

Diseases related to Appendix Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 192)
# Related Disease Score Top Affiliating Genes
1 anus cancer 10.4 CDX2 KRT7
2 hidradenocarcinoma 10.4 CDX2 KRT7
3 sex cord-gonadal stromal tumor 10.4 GNAS KRT7
4 pregnancy adenoma 10.4 GNAS KRT7
5 ovarian clear cell carcinoma 10.4 KRAS KRT7
6 ovary neuroendocrine neoplasm 10.3 CDX2 KRT7
7 mucinous adenofibroma 10.3 CDX2 KRT7
8 large cell neuroendocrine carcinoma 10.3 KRT20 KRT7
9 anus adenocarcinoma 10.3 CDX2 KRT7
10 immune system organ benign neoplasm 10.3 KRT20 KRT7
11 thymus lipoma 10.3 KRT20 KRT7
12 ovarian brenner tumor 10.3 KRT20 KRT7
13 inverted papilloma 10.3 KRT20 KRT7
14 ovarian cystic teratoma 10.3 KRT20 KRT7
15 cervical adenosquamous carcinoma 10.3 KRT7 MUC6
16 epithelial predominant wilms' tumor 10.3 CDX2 KRT7
17 nasal cavity cancer 10.3 CDX2 KRT7
18 cystic basal cell carcinoma 10.3 KRT20 KRT7
19 seminal vesicle adenocarcinoma 10.3 KRT20 KRT7
20 transverse colon cancer 10.3 KRT20 KRT7
21 malignant syringoma 10.3 KRT20 KRT7
22 papillary transitional carcinoma 10.3 KRT20 KRT7
23 vaginal benign neoplasm 10.3 CDX2 KRT20
24 eyelid carcinoma 10.3 KRT20 KRT7
25 urachal adenocarcinoma 10.3 GNAS KRAS
26 vaginal adenoma 10.3 CDX2 KRT20
27 krukenberg carcinoma 10.3 KRT20 KRT7
28 vaginal tubulovillous adenoma 10.3 CDX2 KRT20
29 large intestine adenocarcinoma 10.3 KRT20 KRT7
30 linitis plastica 10.3 KRT20 KRT7
31 lung acinar adenocarcinoma 10.3 KRT20 KRT7
32 small cell carcinoma of the bladder 10.3 KRT20 KRT7
33 adenoid squamous cell carcinoma 10.2 KRT20 KRT7
34 mixed cell type cancer 10.2 HRAS KRT7
35 intratubular embryonal carcinoma 10.2 KRT20 KRT7
36 epithelial-myoepithelial carcinoma 10.2 HRAS KRT7
37 mucinous intrahepatic cholangiocarcinoma 10.2 CDX2 MUC6
38 vulval paget's disease 10.2 KRT20 KRT7
39 cervical polyp 10.2 CDX2 MUC6
40 meibomian cyst 10.2 KRT20 KRT7
41 multinodular goiter 10.2 GNAS HRAS
42 bladder lymphoma 10.2 KRT20 KRT7
43 papillary serous adenocarcinoma 10.2 KRT20 KRT7
44 costello syndrome 10.2 HRAS KRAS
45 pulmonic stenosis 10.2 HRAS KRAS
46 exanthem 10.2 HRAS KRAS
47 mucinous lung adenocarcinoma 10.2 HRAS KRAS
48 endocervical carcinoma 10.2 KRT7 MUC6
49 liver angiosarcoma 10.2 HRAS KRAS
50 adenosquamous lung carcinoma 10.2 HRAS KRAS

Graphical network of the top 20 diseases related to Appendix Disease:



Diseases related to Appendix Disease

Symptoms & Phenotypes for Appendix Disease

GenomeRNAi Phenotypes related to Appendix Disease according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.47 HRAS KRAS MUC1
2 Decreased viability GR00106-A-0 9.47 KRAS
3 Decreased viability GR00221-A-1 9.47 HRAS KRAS
4 Decreased viability GR00221-A-2 9.47 HRAS KRAS
5 Decreased viability GR00221-A-3 9.47 HRAS
6 Decreased viability GR00301-A 9.47 KRAS
7 Decreased viability GR00381-A-1 9.47 KRAS
8 Decreased viability GR00402-S-2 9.47 HRAS KRAS MUC1

Drugs & Therapeutics for Appendix Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Follow up by US Following Hospitalization With Periappendicular Abscess Refusing to be Operated on Within a Few Weeks. Unknown status NCT01795560

Search NIH Clinical Center for Appendix Disease

Genetic Tests for Appendix Disease

Anatomical Context for Appendix Disease

MalaCards organs/tissues related to Appendix Disease:

42
Appendix, Colon, Lung, Ovary, Pancreas, Kidney, Thymus

The Foundational Model of Anatomy Ontology organs/tissues related to Appendix Disease:

20
The Appendix

Publications for Appendix Disease

Articles related to Appendix Disease:

# Title Authors Year
1
INTESTINAL CRISES SIMULATING CHRONIC APPENDIX DISEASE DIAGNOSED BY ROENTGEN RAY FINDINGS. ( 18737404 )
1917

Variations for Appendix Disease

Expression for Appendix Disease

Search GEO for disease gene expression data for Appendix Disease.

Pathways for Appendix Disease

Pathways related to Appendix Disease according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.74 GNAS HRAS KRAS KRT20
2
Show member pathways
12.73 CDX2 GNAS HRAS KRAS
3
Show member pathways
12.13 GNAS HRAS KRAS
4
Show member pathways
11.83 GNAS HRAS KRAS
5
Show member pathways
11.72 GNAS HRAS KRAS
6
Show member pathways
11.67 HRAS KRAS MUC1 MUC6
7 11.49 GNAS HRAS KRAS
8 11.28 GNAS HRAS KRAS
9 11.22 HRAS KRAS
10 11.14 GNAS HRAS KRAS
11 11.08 HRAS KRAS
12 11.01 HRAS KRAS
13 11 HRAS KRAS
14
Show member pathways
10.97 HRAS KRAS
15
Show member pathways
10.91 HRAS KRAS
16 10.84 HRAS KRAS
17 10.8 HRAS KRAS
18 10.71 HRAS KRAS
19 10.58 GNAS HRAS KRAS
20 10.44 HRAS KRAS

GO Terms for Appendix Disease

Biological processes related to Appendix Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of long-term neuronal synaptic plasticity GO:0048169 9.16 HRAS KRAS
2 response to isolation stress GO:0035900 8.96 HRAS KRAS
3 stimulatory C-type lectin receptor signaling pathway GO:0002223 8.92 HRAS KRAS MUC1 MUC6

Molecular functions related to Appendix Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 methyl-CpG binding GO:0008327 8.62 CDX2 ZBTB38

Sources for Appendix Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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