MCID: APP016
MIFTS: 27

Apple Allergy

Categories: Immune diseases

Aliases & Classifications for Apple Allergy

MalaCards integrated aliases for Apple Allergy:

Name: Apple Allergy 12 15
Malus Domestica Fruit Allergy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060504

Summaries for Apple Allergy

Disease Ontology : 12 A fruit allergy triggered by Malus domestica plant fruit food product.

MalaCards based summary : Apple Allergy, also known as malus domestica fruit allergy, is related to pollen allergy and food allergy. An important gene associated with Apple Allergy is PDCL (Phosducin Like), and among its related pathways/superpathways are Immune response NFAT in immune response and Th17 cell differentiation. Affiliated tissues include heart and skin.

Related Diseases for Apple Allergy

Diseases related to Apple Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 pollen allergy 30.3 SCP2 PDCL PDC
2 food allergy 30.0 SPINK5 SCP2
3 fruit allergy 29.9 SCP2 PDCL PDC
4 peach allergy 29.4 SCP2 PPIC PDCL PDC
5 nut allergy 10.2 SCP2 PDCL
6 vegetable allergy 10.2 SCP2 PDCL
7 tomato allergy 10.2 PDCL PDC
8 timothy grass allergy 10.2 PDCL PDC
9 limbic encephalitis with lgi1 antibodies 10.1 HLA-DRB1 HLA-DQB1
10 autoimmune polyglandular syndrome type 3 10.1 HLA-DRB1 HLA-DQB1
11 idiopathic hypersomnia 10.1 HLA-DRB1 HLA-DQB1
12 hypersomnia 10.1 HLA-DRB1 HLA-DQB1
13 narcolepsy 2 10.1 HLA-DRB1 HLA-DQB1
14 htlv-1 associated myelopathy/tropical spastic paraparesis 10.1 HLA-DRB1 HLA-DQB1
15 latent autoimmune diabetes in adults 10.1 HLA-DRB1 HLA-DQB1
16 primary adrenal insufficiency 10.1 HLA-DRB1 HLA-DQB1
17 recurrent respiratory papillomatosis 10.1 HLA-DRB1 HLA-DQB1
18 nasal cavity disease 10.1 PDCL PDC
19 metal allergy 10.1 HLA-DRB1 HLA-DQB1
20 autoimmune hepatitis type 1 10.1 HLA-DRB1 HLA-DQB1
21 focal epithelial hyperplasia 10.1 HLA-DRB1 HLA-DQB1
22 pediatric multiple sclerosis 10.1 HLA-DRB1 HLA-DQB1
23 podoconiosis 10.1 HLA-DRB1 HLA-DQB1
24 pemphigoid 10.1 HLA-DRB1 HLA-DQB1
25 osteonecrosis of the jaw 10.1 HLA-DRB1 HLA-DQB1
26 pityriasis rosea 10.1 HLA-DRB1 HLA-DQB1
27 nose disease 10.1 PDCL PDC
28 narcolepsy 1 10.1 HLA-DRB1 HLA-DQB1
29 idiopathic nephrotic syndrome 10.1 HLA-DRB1 HLA-DQB1
30 ocular cicatricial pemphigoid 10.1 HLA-DRB1 HLA-DQB1
31 cicatricial pemphigoid 10.1 HLA-DRB1 HLA-DQB1
32 alveolar echinococcosis 10.1 HLA-DRB1 HLA-DQB1
33 paraneoplastic pemphigus 10.1 HLA-DRB1 HLA-DQB1
34 cytomegalovirus retinitis 10.1 HLA-DRB1 HLA-DQB1
35 cystic echinococcosis 10.1 HLA-DRB1 HLA-DQB1
36 pure red-cell aplasia 10.1 HLA-DRB1 HLA-DQB1
37 trachoma 10.1 HLA-DRB1 HLA-DQB1
38 microscopic colitis 10.1 HLA-DRB1 HLA-DQB1
39 autoimmune gastritis 10.1 HLA-DRB1 HLA-DQB1
40 acute disseminated encephalomyelitis 10.1 HLA-DRB1 HLA-DQB1
41 cervical dystonia 10.1 HLA-DRB1 HLA-DQB1
42 acute chest syndrome 10.1 HLA-DRB1 HLA-DQB1
43 panuveitis 10.0 HLA-DRB1 HLA-DQB1
44 idiopathic bronchiectasis 10.0 HLA-DRB1 HLA-DQB1
45 guillain-barre syndrome 10.0 HLA-DRB1 HLA-DQB1
46 allergic bronchopulmonary aspergillosis 10.0 HLA-DRB1 HLA-DQB1
47 buerger disease 10.0 HLA-DRB1 HLA-DPB1
48 berylliosis 10.0 HLA-DRB1 HLA-DPB1
49 rheumatic fever 10.0 HLA-DRB1 HLA-DQB1
50 rheumatic heart disease 10.0 HLA-DRB1 HLA-DQB1

Graphical network of the top 20 diseases related to Apple Allergy:



Diseases related to Apple Allergy

Symptoms & Phenotypes for Apple Allergy

Drugs & Therapeutics for Apple Allergy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sublingual Immunotherapy of Birch Pollen Associated Apple Allergy Completed NCT01449786 Phase 2 rMal d 1;rBet v 1

Search NIH Clinical Center for Apple Allergy

Genetic Tests for Apple Allergy

Anatomical Context for Apple Allergy

MalaCards organs/tissues related to Apple Allergy:

40
Heart, Skin

Publications for Apple Allergy

Articles related to Apple Allergy:

(show all 45)
# Title Authors PMID Year
1
IgE-blocking antibodies following SLIT with recombinant Mal d 1 accord with improved apple allergy. 61
32259540 2020
2
Allergen-specific immunotherapy with apples: selected cultivars could be a promising tool for birch pollen allergy. 61
31953891 2020
3
The Effect of Birch Pollen Immunotherapy on Apple and rMal d 1 Challenges in Adults with Apple Allergy. 61
32085633 2020
4
The Incidence of Delayed-Type Hypersensitivity Reactions to Apples Among Patients Allergic to Birch Pollen. 61
29949838 2018
5
Efficacy and safety of 4 months of sublingual immunotherapy with recombinant Mal d 1 and Bet v 1 in patients with birch pollen-related apple allergy. 61
28870463 2018
6
Allergen immunotherapy for birch-apple syndrome: what do we know? 61
29130794 2017
7
Birch pollen immunotherapy inhibits anaphylaxis to the cross-reactive apple allergen Mal d 1 in mice. 61
27376790 2016
8
Recombinant Mal d 1 facilitates sublingual challenge tests of birch pollen-allergic patients with apple allergy. 61
26443126 2016
9
LONG-TERM FOLLOW-UP OF A CASE OF APPLE ALLERGY WITH SYSTEMIC SYMPTOMS THROUGH ORAL FOOD CHALLENGES. 61
27885206 2016
10
Immunotherapy (oral and sublingual) for food allergy to fruits. 61
26558953 2015
11
Placental immune response to apple allergen in allergic mothers. 61
25048667 2014
12
High prevalence of lipid transfer protein sensitization in apple allergic patients with systemic symptoms. 61
25210741 2014
13
Recombinant Mal d 1 is a reliable diagnostic tool for birch pollen allergen-associated apple allergy. 61
23810767 2013
14
[A case of apple allergy with initial symptoms like food-dependent exercise-induced anaphylaxis]. 61
23969882 2013
15
Oral exposure to Mal d 1 affects the immune response in patients with birch pollen allergy. 61
22921871 2013
16
Continuous apple consumption induces oral tolerance in birch-pollen-associated apple allergy. 61
22070352 2012
17
Identification of european allergy patterns to the allergen families PR-10, LTP, and profilin from Rosaceae fruits. 61
19851893 2011
18
Birch-apple syndrome treated with birch pollen immunotherapy. 61
21832831 2011
19
Anaphylaxis to apple: is fasting a risk factor for LTP-allergic patients? 61
21114199 2010
20
Lipid transfer protein in diagnosis of birch-apple syndrome in children. 61
18241693 2008
21
Successful sublingual immunotherapy with birch pollen has limited effects on concomitant food allergy to apple and the immune response to the Bet v 1 homolog Mal d 1. 61
17204315 2007
22
PT with heat-processed apple peel extract to detect LTP hypersensitivity. 61
17274519 2006
23
Apple allergy across Europe: how allergen sensitization profiles determine the clinical expression of allergies to plant foods. 61
16890775 2006
24
Effect of postharvest storage on the expression of the apple allergen Mal d 1. 61
16881695 2006
25
Characterization of recombinant Mal d 4 and its application for component-resolved diagnosis of apple allergy. 61
16911365 2006
26
A mutant of the major apple allergen, Mal d 1, demonstrating hypo-allergenicity in the target organ by double-blind placebo-controlled food challenge. 61
16393331 2005
27
In vivo assessment with prick-to-prick testing and double-blind, placebo-controlled food challenge of allergenicity of apple cultivars. 61
16275380 2005
28
Silencing the major apple allergen Mal d 1 by using the RNA interference approach. 61
15696096 2005
29
Severe allergy to sharon fruit caused by birch pollen. 61
15591813 2005
30
Effects of birch pollen SIT on apple allergy: a matter of dosage? 61
15507094 2004
31
Allergy to jackfruit: a novel example of Bet v 1-related food allergy. 61
15461600 2004
32
Efficacy of birch-pollen immunotherapy on cross-reactive food allergy confirmed by skin tests and double-blind food challenges. 61
15144469 2004
33
How long does the effect of birch pollen injection SIT on apple allergy last? 61
12752332 2003
34
Clinical role of a lipid transfer protein that acts as a new apple-specific allergen. 61
10550759 1999
35
Molecular characterization of Dau c 1, the Bet v 1 homologous protein from carrot and its cross-reactivity with Bet v 1 and Api g 1. 61
10336602 1999
36
Effects of birch pollen-specific immunotherapy on apple allergy in birch pollen-hypersensitive patients. 61
9824409 1998
37
Xenobiotics and food allergy: in vivo and in vitro studies in patients with apple allergy. 61
9130575 1997
38
Characterization of apple 18 and 31 kd allergens by microsequencing and evaluation of their content during storage and ripening. 61
8543755 1995
39
Effect of hyposensitization for tree pollinosis on associated apple allergy. 61
8574432 1995
40
Isolation and characterization of the 18-kDa major apple allergen and comparison with the major birch pollen allergen (Bet v I). 61
7573831 1995
41
Apple allergy: the IgE-binding potency of apple strains is related to the occurrence of the 18-kDa allergen. 61
7518656 1994
42
[Frequency of the so-called "apple allergy" ("apple contact urticaria syndrome") in patients with birch pollinosis]. 61
6858282 1983
43
Extraction and properties of apple allergens. 61
7224105 1980
44
Allergy to birch pollen and apple, and cross-reactivity of the allergens studied with the RAST. 61
7446869 1980
45
Apple allergy. 61
4643415 1972

Variations for Apple Allergy

Expression for Apple Allergy

Search GEO for disease gene expression data for Apple Allergy.

Pathways for Apple Allergy

Pathways related to Apple Allergy according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.3 HLA-DRB1 HLA-DQB1 HLA-DPB1
2
Show member pathways
12.27 HLA-DRB1 HLA-DQB1 HLA-DPB1
3
Show member pathways
12.22 HLA-DRB1 HLA-DQB1 HLA-DPB1
4
Show member pathways
12.06 HLA-DRB1 HLA-DQB1 HLA-DPB1
5 12.04 HLA-DRB1 HLA-DQB1 HLA-DPB1
6
Show member pathways
11.96 HLA-DRB1 HLA-DQB1 HLA-DPB1
7 11.93 HLA-DRB1 HLA-DQB1 HLA-DPB1
8
Show member pathways
11.89 HLA-DRB1 HLA-DQB1 HLA-DPB1
9 11.81 HLA-DRB1 HLA-DQB1 HLA-DPB1
10 11.75 HLA-DRB1 HLA-DQB1 HLA-DPB1
11 11.59 HLA-DRB1 HLA-DQB1 HLA-DPB1
12
Show member pathways
11.58 HLA-DRB1 HLA-DQB1 HLA-DPB1
13 11.51 HLA-DRB1 HLA-DQB1 HLA-DPB1
14 11.43 HLA-DRB1 HLA-DQB1
15 11.43 HLA-DRB1 HLA-DQB1 HLA-DPB1
16 11.31 HLA-DRB1 HLA-DQB1 HLA-DPB1
17 11.1 HLA-DRB1 HLA-DQB1 HLA-DPB1
18
Show member pathways
10.76 HLA-DRB1 HLA-DQB1 HLA-DPB1

GO Terms for Apple Allergy

Cellular components related to Apple Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosome GO:0005764 9.65 HLA-DRB1 HLA-DQB1 HLA-DPB1
2 lysosomal membrane GO:0005765 9.63 HLA-DRB1 HLA-DQB1 HLA-DPB1
3 endosome membrane GO:0010008 9.61 HLA-DRB1 HLA-DQB1 HLA-DPB1
4 trans-Golgi network membrane GO:0032588 9.58 HLA-DRB1 HLA-DQB1 HLA-DPB1
5 endocytic vesicle membrane GO:0030666 9.54 HLA-DRB1 HLA-DQB1 HLA-DPB1
6 ER to Golgi transport vesicle membrane GO:0012507 9.5 HLA-DRB1 HLA-DQB1 HLA-DPB1
7 transport vesicle membrane GO:0030658 9.43 HLA-DRB1 HLA-DQB1 HLA-DPB1
8 clathrin-coated endocytic vesicle membrane GO:0030669 9.33 HLA-DRB1 HLA-DQB1 HLA-DPB1
9 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-DRB1 HLA-DQB1 HLA-DPB1
10 MHC class II protein complex GO:0042613 8.8 HLA-DRB1 HLA-DQB1 HLA-DPB1

Biological processes related to Apple Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell receptor signaling pathway GO:0050852 9.58 HLA-DRB1 HLA-DQB1 HLA-DPB1
2 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.54 HLA-DRB1 HLA-DQB1 HLA-DPB1
3 regulation of G protein-coupled receptor signaling pathway GO:0008277 9.43 PDCL PDC
4 interferon-gamma-mediated signaling pathway GO:0060333 9.43 HLA-DRB1 HLA-DQB1 HLA-DPB1
5 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.32 HLA-DRB1 HLA-DQB1
6 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.16 HLA-DRB1 HLA-DQB1
7 antigen processing and presentation GO:0019882 9.13 HLA-DRB1 HLA-DQB1 HLA-DPB1
8 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 8.8 HLA-DRB1 HLA-DQB1 HLA-DPB1

Molecular functions related to Apple Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 8.96 HLA-DRB1 HLA-DQB1
2 peptide antigen binding GO:0042605 8.8 HLA-DRB1 HLA-DQB1 HLA-DPB1

Sources for Apple Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....