MCID: APP016
MIFTS: 34

Apple Allergy

Categories: Immune diseases

Aliases & Classifications for Apple Allergy

MalaCards integrated aliases for Apple Allergy:

Name: Apple Allergy 12 15
Malus Domestica Fruit Allergy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060504

Summaries for Apple Allergy

Disease Ontology : 12 A fruit allergy triggered by Malus domestica plant fruit food product.

MalaCards based summary : Apple Allergy, also known as malus domestica fruit allergy, is related to food allergy and ascaridiasis. An important gene associated with Apple Allergy is CCL22 (C-C Motif Chemokine Ligand 22), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. Affiliated tissues include testes, and related phenotypes are cellular and hematopoietic system

Related Diseases for Apple Allergy

Diseases related to Apple Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 food allergy 28.7 FOXP3 IL10 IL13 IL4 IL5
2 ascaridiasis 10.3 IL10 IL13
3 endotheliitis 10.3 CXCL10 CXCL11
4 palladium allergic contact dermatitis 10.3 CCL17 IL10
5 trichuriasis 10.3 IL10 IL13
6 opsoclonus-myoclonus syndrome 10.3 CXCL10 CXCL11
7 cytokine deficiency 10.2 IL13 IL5
8 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL13 IL5
9 respiratory syncytial virus infectious disease 10.2 IL13 IL5
10 neurosyphilis 10.2 CXCL10 IL10
11 lipoid nephrosis 10.2 IL10 IL13
12 strongyloidiasis 10.2 IL13 IL5
13 ascaris lumbricoides infection 10.2 IL13 IL5
14 esophagitis, eosinophilic, 1 10.2 IL13 IL5
15 fungal meningitis 10.2 CXCL10 IL10
16 cephalosporin allergy 10.2 IL10 IL5
17 cow milk allergy 10.2 IL10 IL5
18 spotted fever 10.2 CXCL10 IL10
19 multicentric castleman disease 10.2 IL10 IL5
20 primary peritoneal carcinoma 10.1 CXCL10 IL10
21 acute pyelonephritis 10.1 CXCL10 IL10
22 autoimmune atherosclerosis 10.1 FOXP3 IL10
23 nut allergy 10.1 FOXP3 IL5
24 viral encephalitis 10.1 CXCL10 IL10
25 autoimmune disease of eyes, ear, nose and throat 10.1 FOXP3 IL10
26 autoimmune optic neuritis 10.1 FOXP3 IL10
27 tick-borne encephalitis 10.1 CXCL10 CXCL11 IL10
28 paragonimiasis 10.0 CCL17 IL13 IL5
29 autoimmune peripheral neuropathy 10.0 CXCL10 FOXP3
30 penicillin allergy 10.0 IL13 IL4
31 pneumonia 10.0 IL10 IL13 IL5
32 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0 FOXP3 IL10
33 tropical endomyocardial fibrosis 10.0 IL10 IL4
34 endomyocardial fibrosis 10.0 IL10 IL4
35 autoimmune pancreatitis 10.0 FOXP3 IL10
36 hyperlucent lung 10.0 IL10 IL4
37 radiculopathy 10.0 IL10 IL13 IL5
38 tungiasis 10.0 IL10 IL4
39 retinitis pigmentosa 22 10.0 IL10 IL4
40 baylisascariasis 10.0 IL10 IL4
41 cryoglobulinemia 10.0 CXCL10 CXCL11
42 churg-strauss syndrome 10.0 CCL17 IL10 IL5
43 echinococcosis 10.0 CCL17 IL10 IL5
44 autoimmune gastritis 10.0 IL10 IL4
45 orofacial granulomatosis 10.0 IL10 IL4
46 buruli ulcer 10.0 IL10 IL4
47 bardet-biedl syndrome 15 10.0 IL10 IL4
48 primary systemic mycosis 10.0 IL10 IL4
49 poliomyelitis 10.0 IL10 IL4
50 eales disease 10.0 IL10 IL4

Graphical network of the top 20 diseases related to Apple Allergy:



Diseases related to Apple Allergy

Symptoms & Phenotypes for Apple Allergy

MGI Mouse Phenotypes related to Apple Allergy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.91 BIK CCL17 CXCL10 FOXP3 IL10 IL13
2 hematopoietic system MP:0005397 9.86 BIK CCL17 CXCL10 FOXP3 IL10 IL13
3 immune system MP:0005387 9.81 BIK CCL17 CCL22 CXCL10 FOXP3 IL10
4 digestive/alimentary MP:0005381 9.72 FOXP3 IL10 IL13 IL4 IL5
5 reproductive system MP:0005389 9.43 BIK FOXP3 IL10 IL13 IL4 IL5
6 respiratory system MP:0005388 9.02 FOXP3 IL10 IL13 IL4 IL5

Drugs & Therapeutics for Apple Allergy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sublingual Immunotherapy of Birch Pollen Associated Apple Allergy Completed NCT01449786 Phase 2 rMal d 1;rBet v 1

Search NIH Clinical Center for Apple Allergy

Genetic Tests for Apple Allergy

Anatomical Context for Apple Allergy

MalaCards organs/tissues related to Apple Allergy:

42
Testes

Publications for Apple Allergy

Articles related to Apple Allergy:

(show all 14)
# Title Authors Year
1
Efficacy and safety of 4A months of sublingual immunotherapy with recombinant Mal d 1 and Bet v 1 in patients with birch pollen-related apple allergy. ( 28870463 )
2017
2
Recombinant Mal d 1 facilitates sublingual challenge tests of birch pollen-allergic patients with apple allergy. ( 26443126 )
2016
3
LONG-TERM FOLLOW-UP OF A CASE OF APPLE ALLERGY WITH SYSTEMIC SYMPTOMS THROUGH ORAL FOOD CHALLENGES. ( 27885206 )
2016
4
Recombinant Mal d 1 is a reliable diagnostic tool for birch pollen allergen-associated apple allergy. ( 23810767 )
2013
5
Continuous apple consumption induces oral tolerance in birch-pollen-associated apple allergy. ( 22070352 )
2012
6
Characterization of recombinant Mal d 4 and its application for component-resolved diagnosis of apple allergy. ( 16911365 )
2006
7
Apple allergy across Europe: how allergen sensitization profiles determine the clinical expression of allergies to plant foods. ( 16890775 )
2006
8
Effects of birch pollen SIT on apple allergy: a matter of dosage? ( 15507094 )
2004
9
How long does the effect of birch pollen injection SIT on apple allergy last? ( 12752332 )
2003
10
Effects of birch pollen-specific immunotherapy on apple allergy in birch pollen-hypersensitive patients. ( 9824409 )
1998
11
Xenobiotics and food allergy: in vivo and in vitro studies in patients with apple allergy. ( 9130575 )
1997
12
Effect of hyposensitization for tree pollinosis on associated apple allergy. ( 8574432 )
1995
13
Apple allergy: the IgE-binding potency of apple strains is related to the occurrence of the 18-kDa allergen. ( 7518656 )
1994
14
Apple allergy. ( 4643415 )
1972

Variations for Apple Allergy

Expression for Apple Allergy

Search GEO for disease gene expression data for Apple Allergy.

Pathways for Apple Allergy

Pathways related to Apple Allergy according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13
2
Show member pathways
13.52 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13
3
Show member pathways
13.36 CCL17 CCL22 IL10 IL13 IL4 IL5
4
Show member pathways
13.23 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13
5
Show member pathways
13.19 CCL22 CXCL10 IL10 IL13 IL4 IL5
6
Show member pathways
13.1 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13
7
Show member pathways
12.75 CXCL11 FOXP3 IL10 IL13 IL4 IL5
8
Show member pathways
12.72 CCL17 CCL22 CXCL10 CXCL11
9
Show member pathways
12.5 FOXP3 IL10 IL13 IL4 IL5
10 12.44 CXCL10 FOXP3 IL10 IL4
11
Show member pathways
12.28 IL10 IL13 IL4 IL5
12
Show member pathways
12.25 IL10 IL4 IL5
13
Show member pathways
12.24 CCL17 CXCL10 IL13 IL4 IL5
14
Show member pathways
12.14 IL10 IL13 IL4 IL5
15
Show member pathways
12.06 CCL17 CCL22 CXCL10 CXCL11
16
Show member pathways
12.06 CCL17 CCL22 IL10
17
Show member pathways
12.04 CXCL10 CXCL11 IL4
18
Show member pathways
11.95 CCL17 CCL22 IL10 IL13 IL4 IL5
19
Show member pathways
11.92 CCL17 CCL22 CXCL10 CXCL11
20 11.91 CCL22 IL10 IL13 IL4
21 11.88 IL10 IL4 IL5
22 11.73 IL10 IL13 IL4 IL5
23 11.71 IL13 IL4 IL5
24
Show member pathways
11.67 FOXP3 IL4 IL5
25 11.6 CCL17 IL10 IL4 IL5
26 11.57 IL13 IL4 IL5
27 11.41 CCL22 CXCL10 IL10 IL13 IL4
28 11.35 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13
29 11.27 IL13 IL4 IL5
30 11.2 CXCL10 CXCL11
31 11.18 IL4 IL5
32 11.17 IL10 IL13 IL4 IL5
33 11.08 IL10 IL13 IL4 IL5
34 10.99 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13
35 10.83 CCL17 CCL22 FOXP3 IL10 IL13 IL4
36 10.76 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13

GO Terms for Apple Allergy

Cellular components related to Apple Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13
2 extracellular space GO:0005615 9.23 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13

Biological processes related to Apple Allergy according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.93 FOXP3 IL10 IL4 IL5
2 cell-cell signaling GO:0007267 9.85 CCL17 CCL22 CXCL10 CXCL11
3 response to lipopolysaccharide GO:0032496 9.78 CXCL10 IL10 IL13
4 cellular response to lipopolysaccharide GO:0071222 9.77 CXCL10 CXCL11 IL10
5 chemotaxis GO:0006935 9.76 CCL17 CCL22 CXCL10 CXCL11
6 response to virus GO:0009615 9.74 CCL22 CXCL10 FOXP3
7 cytokine-mediated signaling pathway GO:0019221 9.73 CCL22 CXCL10 IL10 IL13 IL4 IL5
8 inflammatory response GO:0006954 9.7 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13
9 positive regulation of B cell proliferation GO:0030890 9.67 IL13 IL4 IL5
10 neutrophil chemotaxis GO:0030593 9.67 CCL17 CCL22 CXCL10 CXCL11
11 negative regulation of tumor necrosis factor production GO:0032720 9.65 FOXP3 IL10
12 negative regulation of endothelial cell apoptotic process GO:2000352 9.65 IL10 IL13 IL4
13 monocyte chemotaxis GO:0002548 9.64 CCL17 CCL22
14 negative regulation of T cell proliferation GO:0042130 9.64 FOXP3 IL10
15 lymphocyte chemotaxis GO:0048247 9.63 CCL17 CCL22
16 negative regulation of interferon-gamma production GO:0032689 9.62 FOXP3 IL10
17 negative regulation of interleukin-6 production GO:0032715 9.62 FOXP3 IL10
18 chemokine-mediated signaling pathway GO:0070098 9.62 CCL17 CCL22 CXCL10 CXCL11
19 negative regulation of myoblast differentiation GO:0045662 9.61 CCL17 CXCL10
20 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.61 CXCL10 CXCL11 IL13
21 positive regulation of cAMP-mediated signaling GO:0043950 9.59 CXCL10 CXCL11
22 positive regulation of macrophage activation GO:0043032 9.58 IL10 IL13
23 T cell chemotaxis GO:0010818 9.58 CXCL10 CXCL11
24 leukocyte chemotaxis GO:0030595 9.58 CXCL10 CXCL11 IL10
25 positive regulation of MHC class II biosynthetic process GO:0045348 9.56 IL10 IL4
26 immune response GO:0006955 9.56 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13
27 regulation of isotype switching GO:0045191 9.54 IL10 IL4
28 type 2 immune response GO:0042092 9.52 IL10 IL4
29 negative regulation of complement-dependent cytotoxicity GO:1903660 9.51 IL13 IL4
30 regulation of signaling receptor activity GO:0010469 9.23 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13

Molecular functions related to Apple Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.43 IL10 IL4 IL5
2 CCR chemokine receptor binding GO:0048020 9.37 CCL17 CCL22
3 cytokine receptor binding GO:0005126 9.32 IL13 IL4
4 chemokine activity GO:0008009 9.26 CCL17 CCL22 CXCL10 CXCL11
5 cytokine activity GO:0005125 9.17 CCL17 CCL22 CXCL10 IL10 IL13 IL4
6 CXCR3 chemokine receptor binding GO:0048248 9.16 CXCL10 CXCL11

Sources for Apple Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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