MCID: APP016
MIFTS: 36

Apple Allergy

Categories: Immune diseases

Aliases & Classifications for Apple Allergy

MalaCards integrated aliases for Apple Allergy:

Name: Apple Allergy 12 15
Malus Domestica Fruit Allergy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060504

Summaries for Apple Allergy

Disease Ontology : 12 A fruit allergy triggered by Malus domestica plant fruit food product.

MalaCards based summary : Apple Allergy, also known as malus domestica fruit allergy, is related to food allergy and endotheliitis. An important gene associated with Apple Allergy is SCP2 (Sterol Carrier Protein 2), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. Affiliated tissues include testes, lung and skin, and related phenotypes are hematopoietic system and immune system

Related Diseases for Apple Allergy

Diseases related to Apple Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 food allergy 29.0 FOXP3 IL10 IL13 IL4 IL5 SCP2
2 endotheliitis 10.2 CXCL10 CXCL11
3 ascaridiasis 10.2 IL10 IL13
4 palladium allergic contact dermatitis 10.2 CCL17 IL10
5 trichuriasis 10.2 IL10 IL13
6 opsoclonus-myoclonus syndrome 10.2 CXCL10 CXCL11
7 cytokine deficiency 10.2 IL13 IL5
8 angioimmunoblastic lymphadenopathy with dysproteinemia 10.1 IL13 IL5
9 respiratory syncytial virus infectious disease 10.1 IL13 IL5
10 neurosyphilis 10.1 CXCL10 IL10
11 strongyloidiasis 10.1 IL13 IL5
12 ascaris lumbricoides infection 10.1 IL13 IL5
13 fungal meningitis 10.1 CXCL10 IL10
14 cephalosporin allergy 10.1 IL10 IL5
15 lipoid nephrosis 10.1 IL10 IL13
16 cow milk allergy 10.1 IL10 IL5
17 multicentric castleman disease 10.1 IL10 IL5
18 castleman disease 10.1 IL10 IL5
19 esophagitis, eosinophilic, 1 10.1 IL13 IL5
20 spotted fever 10.1 CXCL10 IL10
21 autoimmune atherosclerosis 10.1 FOXP3 IL10
22 primary peritoneal carcinoma 10.1 CXCL10 IL10
23 acute pyelonephritis 10.1 CXCL10 IL10
24 autoimmune disease of eyes, ear, nose and throat 10.1 FOXP3 IL10
25 tick-borne encephalitis 10.0 CXCL10 CXCL11 IL10
26 autoimmune optic neuritis 10.0 FOXP3 IL10
27 paragonimiasis 10.0 CCL17 IL13 IL5
28 autoimmune peripheral neuropathy 10.0 CXCL10 FOXP3
29 pneumonia 10.0 IL10 IL13 IL5
30 tropical endomyocardial fibrosis 10.0 IL10 IL4
31 endomyocardial fibrosis 10.0 IL10 IL4
32 viral encephalitis 10.0 CXCL10 IL10
33 hyperlucent lung 10.0 IL10 IL4
34 tungiasis 10.0 IL10 IL4
35 retinitis pigmentosa 22 10.0 IL10 IL4
36 baylisascariasis 10.0 IL10 IL4
37 churg-strauss syndrome 10.0 CCL17 IL10 IL5
38 echinococcosis 10.0 CCL17 IL10 IL5
39 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0 FOXP3 IL10
40 autoimmune gastritis 10.0 IL10 IL4
41 orofacial granulomatosis 10.0 IL10 IL4
42 buruli ulcer 10.0 IL10 IL4
43 autoimmune pancreatitis 10.0 FOXP3 IL10
44 bardet-biedl syndrome 15 10.0 IL10 IL4
45 primary systemic mycosis 10.0 IL10 IL4
46 poliomyelitis 10.0 IL10 IL4
47 nut allergy 10.0 FOXP3 IL5 SCP2
48 eales disease 10.0 IL10 IL4
49 cough variant asthma 10.0 IL4 IL5
50 scleritis 10.0 IL4 IL5

Graphical network of the top 20 diseases related to Apple Allergy:



Diseases related to Apple Allergy

Symptoms & Phenotypes for Apple Allergy

MGI Mouse Phenotypes related to Apple Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.86 BIK CCL17 CXCL10 FOXP3 IL10 IL13
2 immune system MP:0005387 9.85 BIK CCL17 CCL22 CXCL10 FOXP3 IL10
3 liver/biliary system MP:0005370 9.35 FOXP3 IL10 IL4 IL5 SCP2
4 reproductive system MP:0005389 9.1 BIK FOXP3 IL10 IL13 IL4 IL5

Drugs & Therapeutics for Apple Allergy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sublingual Immunotherapy of Birch Pollen Associated Apple Allergy Completed NCT01449786 Phase 2 rMal d 1;rBet v 1

Search NIH Clinical Center for Apple Allergy

Genetic Tests for Apple Allergy

Anatomical Context for Apple Allergy

MalaCards organs/tissues related to Apple Allergy:

41
Testes, Lung, Skin, Heart, Eye, Endothelial, T Cells

Publications for Apple Allergy

Articles related to Apple Allergy:

(show all 14)
# Title Authors Year
1
Efficacy and safety of 4A months of sublingual immunotherapy with recombinant Mal d 1 and Bet v 1 in patients with birch pollen-related apple allergy. ( 28870463 )
2017
2
Recombinant Mal d 1 facilitates sublingual challenge tests of birch pollen-allergic patients with apple allergy. ( 26443126 )
2016
3
LONG-TERM FOLLOW-UP OF A CASE OF APPLE ALLERGY WITH SYSTEMIC SYMPTOMS THROUGH ORAL FOOD CHALLENGES. ( 27885206 )
2016
4
Recombinant Mal d 1 is a reliable diagnostic tool for birch pollen allergen-associated apple allergy. ( 23810767 )
2013
5
Continuous apple consumption induces oral tolerance in birch-pollen-associated apple allergy. ( 22070352 )
2012
6
Characterization of recombinant Mal d 4 and its application for component-resolved diagnosis of apple allergy. ( 16911365 )
2006
7
Apple allergy across Europe: how allergen sensitization profiles determine the clinical expression of allergies to plant foods. ( 16890775 )
2006
8
Effects of birch pollen SIT on apple allergy: a matter of dosage? ( 15507094 )
2004
9
How long does the effect of birch pollen injection SIT on apple allergy last? ( 12752332 )
2003
10
Effects of birch pollen-specific immunotherapy on apple allergy in birch pollen-hypersensitive patients. ( 9824409 )
1998
11
Xenobiotics and food allergy: in vivo and in vitro studies in patients with apple allergy. ( 9130575 )
1997
12
Effect of hyposensitization for tree pollinosis on associated apple allergy. ( 8574432 )
1995
13
Apple allergy: the IgE-binding potency of apple strains is related to the occurrence of the 18-kDa allergen. ( 7518656 )
1994
14
Apple allergy. ( 4643415 )
1972

Variations for Apple Allergy

Expression for Apple Allergy

Search GEO for disease gene expression data for Apple Allergy.

Pathways for Apple Allergy

Pathways related to Apple Allergy according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13
2
Show member pathways
13.53 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13
3
Show member pathways
13.36 CCL17 CCL22 IL10 IL13 IL4 IL5
4
Show member pathways
13.23 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13
5
Show member pathways
13.21 CCL22 CXCL10 IL10 IL13 IL4 IL5
6
Show member pathways
13.1 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13
7
Show member pathways
12.75 CXCL11 FOXP3 IL10 IL13 IL4 IL5
8
Show member pathways
12.72 CCL17 CCL22 CXCL10 CXCL11
9
Show member pathways
12.5 FOXP3 IL10 IL13 IL4 IL5
10 12.44 CXCL10 FOXP3 IL10 IL4
11
Show member pathways
12.28 IL10 IL13 IL4 IL5
12
Show member pathways
12.24 CCL17 CXCL10 IL13 IL4 IL5
13
Show member pathways
12.14 IL10 IL13 IL4 IL5
14
Show member pathways
12.06 CCL17 CCL22 CXCL10 CXCL11
15
Show member pathways
12.06 CCL17 CCL22 IL10
16
Show member pathways
12.04 CXCL10 CXCL11 IL4
17
Show member pathways
11.95 CCL17 CCL22 IL10 IL13 IL4 IL5
18
Show member pathways
11.92 CCL17 CCL22 CXCL10 CXCL11
19 11.91 CCL22 IL10 IL13 IL4
20 11.88 IL10 IL4 IL5
21 11.73 IL10 IL13 IL4 IL5
22 11.7 IL13 IL4 IL5
23
Show member pathways
11.66 FOXP3 IL4 IL5
24 11.6 CCL17 IL10 IL4 IL5
25 11.57 IL13 IL4 IL5
26 11.41 CCL22 CXCL10 IL10 IL13 IL4
27 11.35 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13
28 11.26 IL13 IL4 IL5
29 11.2 CXCL10 CXCL11
30 11.18 IL4 IL5
31 11.17 IL10 IL13 IL4 IL5
32 11.08 IL10 IL13 IL4 IL5
33 10.99 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13
34 10.83 CCL17 CCL22 FOXP3 IL10 IL13 IL4
35 10.76 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13

GO Terms for Apple Allergy

Cellular components related to Apple Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13
2 extracellular space GO:0005615 9.23 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13

Biological processes related to Apple Allergy according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.93 FOXP3 IL10 IL4 IL5
2 cell-cell signaling GO:0007267 9.85 CCL17 CCL22 CXCL10 CXCL11
3 response to lipopolysaccharide GO:0032496 9.78 CXCL10 IL10 IL13
4 chemotaxis GO:0006935 9.78 CCL17 CCL22 CXCL10 CXCL11
5 cellular response to lipopolysaccharide GO:0071222 9.77 CXCL10 CXCL11 IL10
6 response to virus GO:0009615 9.75 CCL22 CXCL10 FOXP3
7 cytokine-mediated signaling pathway GO:0019221 9.73 CCL22 CXCL10 IL10 IL13 IL4 IL5
8 inflammatory response GO:0006954 9.7 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13
9 positive regulation of B cell proliferation GO:0030890 9.67 IL13 IL4 IL5
10 neutrophil chemotaxis GO:0030593 9.67 CCL17 CCL22 CXCL10 CXCL11
11 lymphocyte chemotaxis GO:0048247 9.63 CCL17 CCL22
12 negative regulation of endothelial cell apoptotic process GO:2000352 9.63 IL10 IL13 IL4
13 negative regulation of interferon-gamma production GO:0032689 9.62 FOXP3 IL10
14 negative regulation of interleukin-6 production GO:0032715 9.62 FOXP3 IL10
15 chemokine-mediated signaling pathway GO:0070098 9.62 CCL17 CCL22 CXCL10 CXCL11
16 negative regulation of myoblast differentiation GO:0045662 9.61 CCL17 CXCL10
17 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.61 CXCL10 CXCL11 IL13
18 positive regulation of cAMP-mediated signaling GO:0043950 9.59 CXCL10 CXCL11
19 positive regulation of macrophage activation GO:0043032 9.58 IL10 IL13
20 leukocyte chemotaxis GO:0030595 9.58 CXCL10 CXCL11 IL10
21 T cell chemotaxis GO:0010818 9.57 CXCL10 CXCL11
22 positive regulation of MHC class II biosynthetic process GO:0045348 9.56 IL10 IL4
23 immune response GO:0006955 9.56 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13
24 regulation of isotype switching GO:0045191 9.54 IL10 IL4
25 type 2 immune response GO:0042092 9.52 IL10 IL4
26 negative regulation of complement-dependent cytotoxicity GO:1903660 9.51 IL13 IL4
27 regulation of signaling receptor activity GO:0010469 9.23 CCL17 CCL22 CXCL10 CXCL11 IL10 IL13

Molecular functions related to Apple Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.43 IL10 IL4 IL5
2 CCR chemokine receptor binding GO:0048020 9.37 CCL17 CCL22
3 cytokine receptor binding GO:0005126 9.32 IL13 IL4
4 chemokine activity GO:0008009 9.26 CCL17 CCL22 CXCL10 CXCL11
5 cytokine activity GO:0005125 9.17 CCL17 CCL22 CXCL10 IL10 IL13 IL4
6 CXCR3 chemokine receptor binding GO:0048248 9.16 CXCL10 CXCL11

Sources for Apple Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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