MCID: APR001
MIFTS: 53

Apraxia

Categories: Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Apraxia

Summaries for Apraxia

NIH Rare Diseases : 54 Apraxia is a neurological disorder characterized by the inability to perform tasks or movements, despite having the desire and physical ability to perform them. It is caused by damage to the brain, especially the parietal lobe, and can arise from many diseases, tumors, a stroke, or traumatic brain injury. In some cases it is present from birth. There are several types of apraxia, which may occur alone or together. These include:Buccofacial or orofacial apraxia is the inability to carry out facial movements on demand. This may include licking the lips, sticking out the tongue, whistling, coughing, or winking. Ideational apraxia is the inability to carryout learned, complex tasks with multiple, sequential movements. This may include dressing, eating, and bathing. Ideomotor apraxia is the inability to perform a learned task (such as using a tool) or communicate using gestures (like waving good-bye). Limb-kinetic apraxia is the inability to make fine, precise movements with an arm or leg. This may include buttoning a shirt or tying a shoe.  Verbal apraxia is difficulty coordinating mouth and speech movements. Verbal apraxia may be acquired or present from birth. Constructional apraxia is the inability to copy, draw, or construct simple figures. Oculomotor apraxia is difficulty moving the eyes on command. Treatment of apraxia may include physical, speech, or occupational therapy. If apraxia occurs as a symptom of another disorder, treatment should be directed to the underlying condition.

MalaCards based summary : Apraxia, also known as apraxias, is related to ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia and ocular motor apraxia, and has symptoms including seizures, fever and dyspnea. An important gene associated with Apraxia is APTX (Aprataxin), and among its related pathways/superpathways is DNA Damage. The drugs Acetylcholine and Tolvaptan have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and parietal lobe, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Decreased viability with poly (ADPa89ribose)a89polymerasea891 (PARP) inhibitor

Disease Ontology : 12 An agnosia that is a loss of the ability to map out physical actions in order to repeat them in functional activities.

NINDS : 55 Apraxia (called "dyspraxia" if mild) is a neurological disorder characterized by loss of the ability to execute or carry out skilled movements and gestures, despite having the desire and the physical ability to perform them. Apraxia results from dysfunction of the cerebral hemispheres of the brain, especially the parietal lobe, and can arise from many diseases or damage to the brain. There are several kinds of apraxia, which may occur alone or together. The most common is buccofacial or orofacial apraxia, which causes the inability to carry out facial movements on command such as licking lips, whistling, coughing, or winking. Other types of apraxia include limb-kinetic apraxia (the inability to make fine, precise movements with an arm or leg), ideomotor apraxia (the inability to make the proper movement in response to a verbal command), ideational apraxia (the inability to coordinate activities with multiple, sequential movements, such as dressing, eating, and bathing), verbal apraxia (difficulty coordinating mouth and speech movements), constructional apraxia (the inability to copy, draw, or construct simple figures), and oculomotor apraxia (difficulty moving the eyes on command). Apraxia may be accompanied by a language disorder called aphasia. Corticobasal ganglionic degeneration is a disease that causes a variety of types of apraxia, especially in elderly adults.

Wikipedia : 77 Apraxia is a motor disorder caused by damage to the brain (specifically the posterior parietal cortex)... more...

Related Diseases for Apraxia

Diseases related to Apraxia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 241)
# Related Disease Score Top Affiliating Genes
1 ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia 34.6 APTX SETX
2 ocular motor apraxia 34.2 APTX ATM NPHP1
3 ideomotor apraxia 33.9 GRN MAPT
4 childhood apraxia of speech 33.5 FOXP2 ZGRF1
5 gait apraxia 33.4 GRN PSEN1
6 joubert syndrome 1 31.7 CEP104 INPP5E NPHP1
7 agraphia 31.6 GRN MAPT PSEN1
8 pick disease of brain 31.6 GRN MAPT PSEN1
9 progressive non-fluent aphasia 30.7 C9orf72 GRN MAPT PSEN1
10 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 30.6 GRN MAPT
11 aceruloplasminemia 30.2 APTX ATM SETX
12 dementia 30.1 C9orf72 GRN MAPT PSEN1
13 aphasia 30.1 C9orf72 FOXP2 GRN MAPT PSEN1
14 frontotemporal dementia 29.7 C9orf72 GRN MAPT PSEN1
15 visual agnosia 29.5 GRN PSEN1
16 motor neuron disease 29.4 C9orf72 GRN MAPT SETX
17 amyotrophic lateral sclerosis 1 29.0 C9orf72 GRN MAPT PSEN1 SETX
18 semantic dementia 29.0 C9orf72 GRN MAPT PSEN1
19 ataxia-oculomotor apraxia 3 12.6
20 ataxia-oculomotor apraxia 4 12.5
21 rolandic epilepsy, mental retardation, and speech dyspraxia, x-linked 12.5
22 spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 12.2
23 apraxia of eyelid opening 12.2
24 primary progressive apraxia of speech 12.2
25 rolandic epilepsy-speech dyspraxia syndrome 12.1
26 autosomal recessive cerebellar ataxia-pyramidal signs-nystagmus-oculomotor apraxia syndrome 12.0
27 x-linked intellectual disability-ataxia-apraxia syndrome 12.0
28 epilepsy, focal, with speech disorder and with or without mental retardation 12.0
29 pilarowski-bjornsson syndrome 11.8
30 agnosia 11.7
31 foxp2-related speech and language disorders 11.6
32 poretti-boltshauser syndrome 11.5
33 birk-landau-perez syndrome 11.5
34 balint syndrome 11.5
35 developmental coordination disorder 11.5
36 intellectual disability-developmental delay-contractures syndrome 11.5
37 ataxia-telangiectasia 11.4
38 wieacker-wolff syndrome 11.4
39 corticobasal degeneration 11.4
40 alzheimer disease 3 11.3
41 frontotemporal dementia and/or amyotrophic lateral sclerosis 3 11.2
42 simultanagnosia 11.2
43 specific language impairment 11.2
44 joubert syndrome 2 11.1
45 joubert syndrome 16 11.1
46 joubert syndrome 25 11.1
47 mental retardation with language impairment and with or without autistic features 11.0
48 neurodevelopmental disorder with cerebellar atrophy and with or without seizures 11.0
49 learning disability 11.0
50 craniofacial dyssynostosis 11.0

Graphical network of the top 20 diseases related to Apraxia:



Diseases related to Apraxia

Symptoms & Phenotypes for Apraxia

UMLS symptoms related to Apraxia:


seizures, fever, dyspnea, edema, cachexia, vertigo, headache, clumsiness, abnormality of extrapyramidal motor function, torticollis, syncope, cyanosis, icterus, signs and symptoms, signs and symptoms, digestive, other symbolic dysfunction, hot flushes, muscle rigidity, symptoms

GenomeRNAi Phenotypes related to Apraxia according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.35 APTX ATM PNKP SETX XRCC1
2 Decreased viability with poly (ADPa89ribose)a89polymerasea891 (PARP) inhibitor GR00114-A 9.16 ATM PNKP
3 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.02 FOXP2 MAPT PIK3R5 PNKP PSEN1

MGI Mouse Phenotypes related to Apraxia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.73 APTX ATM C9orf72 GRN INPP5E MAPT
2 nervous system MP:0003631 9.28 ATM C9orf72 GRN INPP5E MAPT NPHP1

Drugs & Therapeutics for Apraxia

Drugs for Apraxia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
2
Tolvaptan Approved Phase 4 150683-30-0 216237
3 Acetylcholine Release Inhibitors Phase 4
4 Botulinum Toxins, Type A Phase 4
5 Neurotransmitter Agents Phase 4,Phase 2
6 Cholinergic Agents Phase 4
7 abobotulinumtoxinA Phase 4
8 Botulinum Toxins Phase 4
9 Hormones Phase 4
10 Liver Extracts Phase 4
11 Natriuretic Agents Phase 4
12 Arginine Vasopressin Phase 4
13 Antidiuretic Hormone Receptor Antagonists Phase 4
14 Vasopressins Phase 4
15
Ethanol Approved Phase 3 64-17-5 702
16
Coenzyme Q10 Approved, Investigational, Nutraceutical Phase 3 303-98-0 5281915
17 Nutrients Phase 3
18 Micronutrients Phase 3
19 Vitamins Phase 3
20 Trace Elements Phase 3
21 Complement System Proteins Phase 3
22 Ubiquinone Phase 3
23 Lecithin Phase 3
24 Plasminogen Phase 3
25 Fibrinolytic Agents Phase 3
26 Tissue Plasminogen Activator Phase 3
27
Dopamine Approved Phase 2 62-31-7, 51-61-6 681
28
Memantine Approved, Investigational Phase 2 19982-08-2 4054
29
Benzocaine Approved, Investigational Phase 2,Not Applicable 1994-09-7, 94-09-7 2337
30
tannic acid Approved Phase 2,Not Applicable 1401-55-4
31 Excitatory Amino Acid Antagonists Phase 2
32 Excitatory Amino Acids Phase 2
33 Dopamine Agents Phase 2
34 Antiparkinson Agents Phase 2
35
Corticosterone Experimental Phase 1 50-22-6 5753
36 Deoxyglucose Phase 1
37 Fluorodeoxyglucose F18 Phase 1
38
Calcium Carbonate Approved, Investigational Not Applicable 471-34-1
39
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
40
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
41
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
42
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
43
Silver sulfadiazine Approved, Vet_approved Not Applicable 22199-08-2 441244
44
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
45
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
46
Calcium Approved, Nutraceutical 7440-70-2 271
47
Prednisolone hemisuccinate Experimental Not Applicable 2920-86-7
48 Calciferol
49 Bone Density Conservation Agents
50 Ergocalciferols

Interventional clinical trials:

(show top 50) (show all 74)
# Name Status NCT ID Phase Drugs
1 The Use of Botox in Advanced Parkinson's Patients Experiencing Pain Unknown status NCT02472210 Phase 4 Botulinum Toxin
2 Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech Recruiting NCT01818661 Phase 4 AV-1451
3 Tolvaptan to Reduce Length of Stay in Hospitalized Patients With Cirrhosis and Hyponatremia Terminated NCT01890694 Phase 4 Tolvaptan;Placebo
4 Evolution of Albumin on AOA1 Patients Supplemented With Coenzyme Q10 Completed NCT02333305 Phase 3
5 Intraventricular Fibrinolysis for Aneurysmal Subarachnoid Hemorrhage. Recruiting NCT03187405 Phase 3 EVD + IVF with Alteplase
6 Evaluation of the Efficacy, Safety, and Tolerability of Sarizotan in Rett Syndrome With Respiratory Symptoms Active, not recruiting NCT02790034 Phase 2, Phase 3 Sarizotan;Placebo
7 Electrical Polarization of the Brain in Corticobasal Syndrome Completed NCT00273897 Phase 2
8 A Safety and Tolerability Study of JNJ-54861911 in Participants With Early Alzheimer's Disease Completed NCT02260674 Phase 2 JNJ-54861911, 10 milligram (mg);JNJ-54861911, 50 mg;Placebo
9 A Multi-site Double-blind Placebo-controlled Trial of Memantine Versus Placebo in Children With Autism (MEM) Completed NCT01372449 Phase 2 Memantine;Placebo
10 Transcranial Magnetic Stimulation to Improve Gesture Control Completed NCT03483909 Phase 1, Phase 2
11 Nucleus Basalis Deep Brain Stimulation for Thinking & Memory Problems in Parkinson's. Completed NCT01701544 Phase 1, Phase 2
12 Transcranial Direct Current Stimulation (tDCS) to Improve Gesture Control Recruiting NCT03463902 Phase 1, Phase 2
13 Treatment of Mitochondrial Dysfunction in Rett Syndrome With Triheptanoin Recruiting NCT02696044 Phase 2 triheptanoin
14 Evaluating Anodal tDCS Preceding Aphasia Therapy Terminated NCT02249819 Phase 1, Phase 2
15 PiB PET Scanning in Speech and Language Based Dementias Completed NCT01623284 Phase 1 C-11 PiB;F-18 FDG
16 ASSIST: Treatment for Childhood Apraxia of Speech Recruiting NCT03903120 Phase 1
17 Construction-LBD (Constructional Apraxia in Alzheimer's Disease (AD) and Lewy Body's Dementia (LBD)) Unknown status NCT01993628 Not Applicable
18 Action Observation Treatment (AOT) as a Rehabilitation Tool Unknown status NCT02235350 Not Applicable
19 Scholar Performance and Praxis Assessment in Children With Rolandic Epilepsy Unknown status NCT01046760
20 Transcranial and Rapid Magnetic Stimulation for Gait Apraxia Due to Normal Pressure Hydrocephalus and Cerebral Ischemia Unknown status NCT00494689
21 Study of Adherence and Effects of Balance Exercices (SIEL BLEU Associatio) Unknown status NCT01314638
22 Alzheimer's Disease and Related Disorders Unknown status NCT01315704 Drug intervention
23 Functional Rehabilitation of Upper Limb Apraxia in Patients Poststroke Completed NCT02199093 Not Applicable
24 Treatments of Acquired Apraxia of Speech Completed NCT01483807 Not Applicable
25 Transcranial Magnetic Stimulation (TMS) for Primary Progressive Apraxia of Speech (PPAOS) Completed NCT03028324 Not Applicable
26 Intervention on Caregivers Caring for Patients Poststroke With Upper Limb Apraxia Completed NCT02307019 Not Applicable
27 Auditory Masking Effects on Speech Fluency in Aphasia and Apraxia of Speech Completed NCT02094014
28 Occupational Therapy in Patients With Multiple Sclerosis Completed NCT01507636 Not Applicable
29 EEG and EMG Analysis of Ideomotor Apraxia Completed NCT00024999
30 Stuttering and Apraxia of Speech: the Efficacy of an Intervention Program Completed NCT01097161 Not Applicable
31 Using fMRI to Understand the Roles of Brain Areas for Fine Hand Movements Completed NCT00063115
32 Brain Biomarkers of Response to Treatment for Apraxia of Speech Completed NCT02046941 Not Applicable
33 Evaluation of Intensive Language Therapy Completed NCT02935842 Not Applicable
34 Immersive Virtual Environments and Wearable Haptic Devices in Rehabilitation of Children With Neuromotor Impairments Completed NCT03353623 Not Applicable
35 Gait and Alzheimer Interaction Tracking (GAIT) Study Completed NCT01315717
36 Orientation Agnosia: Clinical and Anatomical Study Completed NCT01304576 Not Applicable
37 Delirium in the Emergency Department: Novel Screening Completed NCT01162343
38 Cognitive Training in Parkinson's Disease Completed NCT01393353 Not Applicable
39 Post-Stroke Aphasia and Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment Study Completed NCT01512264 Not Applicable
40 Rehabilitation Gaming System for Cerebral Palsy Completed NCT02938754 Not Applicable
41 Upper Limbs Intervention in Multiple Sclerosis Completed NCT02047825 Not Applicable
42 Clinical Findings in General Paresis Completed NCT00921648
43 Deep Brain Stimulation for Patients With Dementia With Lewy Bodies Completed NCT02263937 Not Applicable
44 Determinants of Balance Recovery After Stroke - Retrospective Study Completed NCT03203109
45 The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech Recruiting NCT03313011
46 Rehabilitating (Stroke-induced) Apraxia With Direct Current Stimulation Recruiting NCT03185234 Not Applicable
47 Treating Childhood Apraxia of Speech Recruiting NCT03238677 Not Applicable
48 Treatment Intensity - Apraxia of Speech Recruiting NCT02332915 Not Applicable
49 Memory for Action in Neurological Patients Recruiting NCT02844855 Not Applicable
50 Rehabilitation Combined With Bihemispherictranscranial Direct Current Stimulation in Subacute Ischemic Stroke Recruiting NCT01644929 Not Applicable

Search NIH Clinical Center for Apraxia

Genetic Tests for Apraxia

Genetic tests related to Apraxia:

# Genetic test Affiliating Genes
1 Apraxia 30

Anatomical Context for Apraxia

MalaCards organs/tissues related to Apraxia:

42
Brain, Eye, Parietal Lobe, Cortex, Tongue, Testes, Bone

Publications for Apraxia

Articles related to Apraxia:

(show top 50) (show all 1318)
# Title Authors Year
1
Speech Motor Planning in The Context of Phonetically Similar Words: Evidence from Apraxia of Speech and Aphasia. ( 30817912 )
2019
2
Sound Distortion Errors in Aphasia With Apraxia of Speech. ( 31072155 )
2019
3
Variables associated with speech and language therapy time for aphasia, apraxia of speech and dysarthria. ( 31073381 )
2019
4
Apraxia screening predicts Alzheimer pathology in frontotemporal dementia. ( 30305323 )
2019
5
Word-level prosodic measures and the differential diagnosis of apraxia of speech. ( 30486684 )
2019
6
A new MRI marker of ataxia with oculomotor apraxia. ( 30599859 )
2019
7
Sub-classification of apraxia of speech in patients with cerebrovascular and neurodegenerative diseases. ( 30622034 )
2019
8
Germ cell arrest associated with aSETX mutation in ataxia oculomotor apraxia type 2. ( 30642639 )
2019
9
Primary Progressive Aphasias and Apraxia of Speech. ( 30707189 )
2019
10
Lexical stress in childhood apraxia of speech: acoustic and kinematic findings. ( 30744428 )
2019
11
Disruption of Spermatogenesis and Infertility in Ataxia with Oculomotor Apraxia Type 2 (AOA2). ( 30778901 )
2019
12
Modalities of reading acquisition in three siblings with infantile-onset saccade initiation delay (Cogan congenital ocular motor apraxia): A longitudinal study. ( 30782493 )
2019
13
Is There Really a Loss of Agency in Patients With Apraxia of Tool Use? ( 30804829 )
2019
14
cTBS over contralesional homologue areas deteriorates speech output in isolated apraxia of speech after stroke. ( 30914261 )
2019
15
Action Observation for Neurorehabilitation in Apraxia. ( 31001194 )
2019
16
Limb apraxia profiles in different clinical samples. ( 31002018 )
2019
17
Ataxia with Oculomotor Apraxia Type 4 with PNKP Common "Portuguese" and Novel Mutations in Two Belarusian Families. ( 31061747 )
2019
18
Apraxia, Neglect, and Agnosia. ( 29851877 )
2018
19
Unilateral Apraxic Agraphia without Ideomotor Apraxia from a callosal lesion in a patient with Marchiafava-Bignami disease. ( 29482459 )
2018
20
Assessing Anosognosia in Apraxia of Common Tool-Use With the VATA-NAT. ( 29636672 )
2018
21
Rate and rhythm control strategies for apraxia of speech in nonfluent primary progressive aphasia. ( 29682238 )
2018
22
Tau uptake in agrammatic primary progressive aphasia with and without apraxia of speech. ( 29935044 )
2018
23
Quantitative Analysis of Agrammatism in Agrammatic Primary Progressive Aphasia and Dominant Apraxia of Speech. ( 30098169 )
2018
24
Error Consistency in Acquired Apraxia of Speech With Aphasia: Effects of the Analysis Unit. ( 29392281 )
2018
25
Language Changes Following Combined Aphasia and Apraxia of Speech Treatment. ( 29497747 )
2018
26
Combined aphasia and apraxia of speech treatment (CAAST): Systematic replications in the development of a novel treatment. ( 28084854 )
2018
27
Non-right handed primary progressive apraxia of speech. ( 29801898 )
2018
28
Disrupted functional connectivity in primary progressive apraxia of speech. ( 29845010 )
2018
29
Interventions for childhood apraxia of speech. ( 29845607 )
2018
30
Diagnostic Apraxia and Ictal Alien Hand. ( 29875540 )
2018
31
A new MAPT deletion in a case of speech apraxia leading to corticobasal syndrome. ( 29969053 )
2018
32
Prosodic and phonetic subtypes of primary progressive apraxia of speech. ( 29980072 )
2018
33
Functional eyelid opening apraxia: a kinematic study. ( 29984899 )
2018
34
Apraxia profiles-A single cognitive marker to discriminate all variants of frontotemporal lobar degeneration and Alzheimer's disease. ( 30003137 )
2018
35
Erratum: Diagnostic Apraxia and Ictal Alien Hand. ( 30093760 )
2018
36
Lower limb apraxia in corticobasal syndrome. ( 30103952 )
2018
37
An Explorative Note on Apraxia Tests. ( 30135679 )
2018
38
Parietal Involvement in Constructional Apraxia as Measured Using the Pentagon Copying Task. ( 30145597 )
2018
39
Diagonistic Apraxia: A Unique Case of Corpus Callosal Disconnection Syndrome and Neuromyelitis Optica Spectrum Disorder. ( 30147671 )
2018
40
A Novel Homozygous Variant of SETX Causes Ataxia with Oculomotor Apraxia Type 2. ( 30198223 )
2018
41
Comorbid morphological disorder apparent in some children aged 4-5 years with childhood apraxia of speech: findings from standardised testing. ( 30199280 )
2018
42
Distortion of Visuo-Motor Temporal Integration in Apraxia: Evidence From Delayed Visual Feedback Detection Tasks and Voxel-Based Lesion-Symptom Mapping. ( 30210434 )
2018
43
Aetiology of childhood apraxia of speech: A clinical practice update for paediatricians. ( 30294994 )
2018
44
Vowel Formant Dispersion Reflects Severity of Apraxia of Speech. ( 30297975 )
2018
45
Limb Kinetic Apraxia Is an Independent Predictor for Quality of Life in Parkinson's Disease. ( 30363441 )
2018
46
Clinical Progression in Four Cases of Primary Progressive Apraxia of Speech. ( 30458509 )
2018
47
rTMS can improve post-stroke apraxia of speech. A case study. ( 30559001 )
2018
48
Ataxia with ocular apraxia type 2 not responding to 4-aminopyridine: A rare mutation in the SETX gene in a Saudi patient. ( 30560021 )
2018
49
Quantifying apraxia and ophthalmokinetic abnormalities in patients with atypical Parkinsonism: A new way to differential diagnosis? ( 30563744 )
2018
50
An Investigation of Compensation and Adaptation to Auditory Perturbations in Individuals With Acquired Apraxia of Speech. ( 30618687 )
2018

Variations for Apraxia

Expression for Apraxia

Search GEO for disease gene expression data for Apraxia.

Pathways for Apraxia

Pathways related to Apraxia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 APTX ATM PNKP XRCC1

GO Terms for Apraxia

Cellular components related to Apraxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 9.63 C9orf72 CEP104 INPP5E MAPT NPHP1 SETX
2 axon GO:0030424 9.56 C9orf72 MAPT PSEN1 SETX
3 main axon GO:0044304 8.96 C9orf72 MAPT
4 growth cone GO:0030426 8.92 C9orf72 MAPT PSEN1 SETX

Biological processes related to Apraxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA repair GO:0006281 9.55 APTX ATM PNKP SETX XRCC1
2 positive regulation of telomere maintenance via telomerase GO:0032212 9.43 ATM PNKP
3 regulation of autophagy GO:0010506 9.43 ATM C9orf72 MAPT
4 stress granule assembly GO:0034063 9.4 C9orf72 MAPT
5 astrocyte activation GO:0048143 9.37 MAPT PSEN1
6 single strand break repair GO:0000012 9.32 APTX XRCC1
7 cellular response to DNA damage stimulus GO:0006974 9.1 APTX ATM PNKP PSEN1 SETX XRCC1
8 negative regulation of protein ADP-ribosylation GO:0010836 8.96 PNKP XRCC1

Molecular functions related to Apraxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-stranded DNA binding GO:0003690 9.13 APTX MAPT PNKP
2 damaged DNA binding GO:0003684 8.8 APTX PNKP XRCC1

Sources for Apraxia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....