MCID: AQG004
MIFTS: 17

Aquagenic Syringeal Acrokeratoderma

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Aquagenic Syringeal Acrokeratoderma

MalaCards integrated aliases for Aquagenic Syringeal Acrokeratoderma:

Name: Aquagenic Syringeal Acrokeratoderma 53 59
Transient Reactive Papulotranslucent Acrokeratoderma 53 59
Aquagenic Palmoplantar Keratoderma 53 59
Aquagenic Wrinkling of the Palms 53 59
Aquagenic Keratoderma 53 59
Aquagenic Wrinkling of the Hands 53

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Orphanet 59 ORPHA498359

Summaries for Aquagenic Syringeal Acrokeratoderma

NIH Rare Diseases : 53 Aquagenic syringeal acrokeratoderma is a rare condition affecting the palms of the hands. It is characterized by the appearance or worsening of a palmar eruption, following brief exposure to water. The palmar eruption is made up of small, white or shining pimples that can conjoin into plaques. The feet are unaffected. Symptoms include a burning pain and a tightening sensation in the palms, as well as too much sweating. There are two variants. Most commonly, it is a temporary and recurrent condition that appears after submersion in water, known as the "hand in the bucket sign," that gets better within minutes to hours of drying. A less common variant is characterized by persistent lesions that are worsened after water submersion. The cause of aquagenic syringeal acrokeratoderma is unknown, but likely relates to sweating. Several studies have found that it is present in about 40% to 84% of cystic fibrosis patients and also in carriers, which suggest that it may be caused by mutations in the CFTR gene. It is more often found in young women. Besides cystic fibrosis, it is also seen in wasting (marasmus) and nephrotic syndrome and also with the use of aspirin and other drugs such as rofecoxib and celecoxib. In most cases it does not need any treatment and resolves spontaneously. When necessary, it can be treated with topical aluminum chloride or salicylic acid ointment or with tap water iontophoresis.

MalaCards based summary : Aquagenic Syringeal Acrokeratoderma, also known as transient reactive papulotranslucent acrokeratoderma, is related to acrokeratoderma and palmoplantar keratosis. An important gene associated with Aquagenic Syringeal Acrokeratoderma is CFTR (CF Transmembrane Conductance Regulator). Affiliated tissues include skin.

Related Diseases for Aquagenic Syringeal Acrokeratoderma

Diseases related to Aquagenic Syringeal Acrokeratoderma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 acrokeratoderma 11.1
2 palmoplantar keratosis 10.7
3 fibrosis of extraocular muscles, congenital, 1 10.6
4 keratosis 10.6
5 cystic fibrosis 10.5
6 ige responsiveness, atopic 10.4
7 hydrops, lactic acidosis, and sideroblastic anemia 10.4
8 polycystic ovary syndrome 10.4
9 acrokeratoderma, hereditary papulotranslucent 10.3
10 langerhans cell histiocytosis 10.3
11 histiocytosis 10.3
12 marasmus 10.3
13 mixed connective tissue disease 10.3
14 skin disease 10.3
15 connective tissue disease 10.3
16 pulmonary alveolar microlithiasis 10.2

Graphical network of the top 20 diseases related to Aquagenic Syringeal Acrokeratoderma:



Diseases related to Aquagenic Syringeal Acrokeratoderma

Symptoms & Phenotypes for Aquagenic Syringeal Acrokeratoderma

Drugs & Therapeutics for Aquagenic Syringeal Acrokeratoderma

Search Clinical Trials , NIH Clinical Center for Aquagenic Syringeal Acrokeratoderma

Genetic Tests for Aquagenic Syringeal Acrokeratoderma

Anatomical Context for Aquagenic Syringeal Acrokeratoderma

MalaCards organs/tissues related to Aquagenic Syringeal Acrokeratoderma:

41
Skin

Publications for Aquagenic Syringeal Acrokeratoderma

Articles related to Aquagenic Syringeal Acrokeratoderma:

(show all 35)
# Title Authors PMID Year
1
Aquagenic Syringeal Acrokeratoderma: Report of a Case with Dermoscopic Findings. 38
30078888 2018
2
A case of aquagenic syringeal acrokeratoderma with involvement of periungual area of the hand. 38
31365219 2018
3
Translucent whitish papules on the palms after exposure to the water - aquagenic syringeal acrokeratoderma. 38
28951715 2017
4
Role of cyclooxygenase inhibitors in aquagenic syringeal acrokeratoderma. 38
26833962 2016
5
Aquagenic syringeal acrokeratoderma. 38
27559519 2016
6
Dermoscopic features of aquagenic syringeal acrokeratoderma. 38
26994017 2016
7
Permanent treatment of aquagenic syringeal acrokeratoderma with endoscopic thoracic sympathectomy. 38
26515860 2015
8
Transient reactive papulotranslucent acrokeratoderma: a report of 3 cases showing excellent response to topical calcipotriene. 38
26682562 2015
9
Aquagenic palmar wrinkling in two Indian patients with special reference to its dermoscopic pattern. 38
26158367 2015
10
Acquired aquagenic syringeal acrokeratoderma: A case series of 10 patients. 38
24283504 2015
11
Case report: Treatment failure in a case of aquagenic syringeal acrokeratoderma. 38
25549815 2015
12
Aquagenic syringeal acrokeratoderma. 38
25484422 2014
13
Watersport hands. 38
24982711 2014
14
Non-steroidal anti-inflammatory drug - induced transient reactive papulotranslucent acrokeratoderma. 38
24653762 2014
15
Atypical form of transient reactive papulotranslucent acrokeratoderma in a cystic fibrosis carrier. 38
23379606 2013
16
Aquagenic syringeal acrokeratoderma. 38
22128881 2012
17
Dermatoscopy as an adjunctive diagnostic tool in aquagenic syringeal acrokeratoderma. 38
22813714 2012
18
Atypical form of transient reactive papulotranslucent acrokeratoderma: a case report and review of the literature. 38
21128920 2010
19
A localized form of aquagenic syringeal acrokeratoderma. 38
19874341 2010
20
Aquagenic syringeal acrokeratoderma in an adult man: case report and review of the literature. 38
20055864 2009
21
Aquagenic syringeal acrokeratoderma. 38
19119115 2008
22
Aquagenic syringeal acrokeratoderma: unusual prominence on the dorsal aspect of fingers? 38
18503605 2008
23
Transient reactive papulotranslucent acrokeratoderma in a 50-year-old woman: case report and review of the literature. 38
18973409 2008
24
Unilateral transient reactive papulotranslucent acrokeratoderma in a child. 38
17958817 2007
25
[Aquagenic syringeal acrokeratoderma]. 38
17374339 2007
26
What is your diagnosis? Aquagenic syringeal acrokeratoderma (ASA). 38
17186786 2006
27
Aquagenic syringeal acrokeratoderma: report of a case with histologic findings. 38
16635679 2006
28
[Aquagenic syringeal acrokeratoderma. Presentation of two cases]. 38
16801024 2006
29
Transient aquagenic palmar hyperwrinkling: the first instance reported in a young boy. 38
16445410 2006
30
Aquagenic syringeal acrokeratoderma. 38
14594600 2003
31
Aquagenic syringeal acrokeratoderma (transient reactive papulotranslucent acrokeratoderma). 38
11834842 2002
32
Aquagenic syringeal acrokeratoderma: report of two teenage cases. 38
11423847 2001
33
Aquagenic palmoplantar keratoderma. 38
11260552 2001
34
Transient reactive papulotranslucent acrokeratoderma associated with cystic fibrosis. 38
10954989 2000
35
Transient reactive papulotranslucent acrokeratoderma. 38
8601664 1996

Variations for Aquagenic Syringeal Acrokeratoderma

Expression for Aquagenic Syringeal Acrokeratoderma

Search GEO for disease gene expression data for Aquagenic Syringeal Acrokeratoderma.

Pathways for Aquagenic Syringeal Acrokeratoderma

GO Terms for Aquagenic Syringeal Acrokeratoderma

Sources for Aquagenic Syringeal Acrokeratoderma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
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44 MeSH
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49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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