MCID: AQS001
MIFTS: 22

Aqueous Misdirection

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Aqueous Misdirection

MalaCards integrated aliases for Aqueous Misdirection:

Name: Aqueous Misdirection 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:11149
ICD9CM 34 365.83
ICD10 32 H40.83
UMLS 70 C1135189

Summaries for Aqueous Misdirection

Disease Ontology : 12 A glaucoma characterized by shallowing of the central and peripheral anterior chamber from posterior pressure such that the intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Aqueous misdirection has symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Aqueous misdirection is caused by an abnormal relationsihp between the ciliary body, lens, and anterior vitreous such that aqueous flow is diverted into the posterior segment, leading to increased posterior pressure, which further closes the angle. Aqueous misdirection may occur in association with glaucoma surgery, trauma, endophthalmitis, and retinopathy of prematurity.

MalaCards based summary : Aqueous Misdirection is related to intraocular pressure quantitative trait locus and cataract, and has symptoms including progressive peripheral vision loss An important gene associated with Aqueous Misdirection is HYAL3 (Hyaluronidase 3). Affiliated tissues include eye, endothelial and thyroid, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Aqueous Misdirection

Diseases related to Aqueous Misdirection via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 intraocular pressure quantitative trait locus 10.4
2 cataract 10.4
3 retinal detachment 10.3
4 nanophthalmos 10.2
5 cycloplegia 10.2
6 open-angle glaucoma 10.2
7 corneal edema 10.2
8 primary angle-closure glaucoma 10.2
9 chronic closed-angle glaucoma 10.2
10 myopia 10.0
11 endophthalmitis 10.0
12 eye disease 10.0
13 arthritis 10.0
14 ocular hypertension 10.0
15 mechanical strabismus 10.0
16 refractive error 10.0
17 chromosomal triplication 10.0
18 keratoconus 10.0
19 corneal disease 10.0
20 alacrima, achalasia, and mental retardation syndrome 10.0
21 persistent hyperplastic primary vitreous, autosomal recessive 10.0
22 down syndrome 10.0
23 strabismus 10.0
24 rheumatoid arthritis 10.0
25 glaucoma, primary open angle 10.0

Graphical network of the top 20 diseases related to Aqueous Misdirection:



Diseases related to Aqueous Misdirection

Symptoms & Phenotypes for Aqueous Misdirection

Symptoms:

12
  • progressive peripheral vision loss

GenomeRNAi Phenotypes related to Aqueous Misdirection according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.4 SHOX
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-130 9.4 SHOX
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-146 9.4 SHOX
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-147 9.4 KRT4
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.4 SHOX
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-176 9.4 SHOX
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-188 9.4 KRT4
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.4 SHOX
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-24 9.4 SHOX
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.4 SHOX
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.4 KRT4
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-67 9.4 KRT4

Drugs & Therapeutics for Aqueous Misdirection

Search Clinical Trials , NIH Clinical Center for Aqueous Misdirection

Genetic Tests for Aqueous Misdirection

Anatomical Context for Aqueous Misdirection

MalaCards organs/tissues related to Aqueous Misdirection:

40
Eye, Endothelial, Thyroid

Publications for Aqueous Misdirection

Articles related to Aqueous Misdirection:

(show top 50) (show all 89)
# Title Authors PMID Year
1
Aqueous Misdirection After Trabeculectomy in a Down Syndrome Patient with Angle-closure Glaucoma. 61
33710067 2021
2
Outcomes of Descemet's membrane endothelial keratoplasty for congenital hereditary endothelial dystrophy. 61
33253860 2020
3
Simultaneous bilateral aqueous misdirection following certolizumab therapy for rheumatoid arthritis. 61
33012711 2020
4
Pars plana vitrectomy combined with hyaloido-zonula-iridectomy in treatment of patients with chronic aqueous misdirection: A systematic literature review and case series. 61
32840056 2020
5
Pars plana vitrectomy combined with irido-zonulo-hyaloidectomy for aqueous misdirection. 61
31466467 2020
6
Outcome and Complications of Combined Modified Deep Sclerectomy and Trabeculectomy for Surgical Management of Glaucoma: A Pilot Study. 61
32210532 2020
7
Bilateral aqueous misdirection syndrome after routine cataract surgery in angle closure. 61
31856996 2019
8
Intra-Operative Ostial Irido-Zonulo-Hyaloido-Vitrectomy with Primary Posterior Capsulectomy for Prevention of Post-Operative Aqueous Misdirection in Combined Phaco-Trabeculectomy in Primary Angle Closure Glaucoma. 61
31136195 2019
9
Unilateral Malignant Glaucoma Postbilateral Implantable Collamer Lens: Effect of Miotics. 61
31619910 2019
10
Management of recurrent aqueous misdirection by anterior segment surgeon after failed pars plana posterior vitrectomy. 61
31238466 2019
11
Successful recovery from misdirection syndrome in nanophthalmic eyes by performing an anterior vitrectomy through the anterior chamber. 61
29299722 2019
12
A Retrospective Study of 199 Xen45 Stent Implantations From 2014 to 2016. 61
30461555 2019
13
RETINAL AND CHOROIDAL VASCULAR OCCLUSION FOLLOWING AQUEOUS MISDIRECTION SYNDROME IN A PATIENT WITH SICKLE CELL TRAIT. 61
28489705 2019
14
Management of Pseudophakic Malignant Glaucoma in Sunset Syndrome: A Case Report and Literature Review. 61
31263719 2019
15
Prophylactic anterior vitrectomy during cataract surgery in eyes at increased risk for aqueous misdirection. 61
30148233 2018
16
Aqueous humor misdirection syndrome after glaucoma filtering surgery in patient with bilateral acute iris transillumination (BAIT) syndrome. 61
29853418 2018
17
Mini-vitrectomy; a Simple Solution to a Serious Condition. 61
30090177 2018
18
Spontaneous onset pseudophakic malignant glaucoma secondary to zonular weakness and cilio-lenticular block. 61
29930458 2018
19
Slit-lamp Needling of the Anterior Capsule for Aqueous Misdirection After Hyaloido-zonulectomy and Iridectomy. 61
29329140 2018
20
Acute and chronic fluid misdirection syndrome: pathophysiology and treatment. 61
29110086 2018
21
25G PARS PLANA VITRECTOMY AND IRIDO-ZONULO-HYALOIDO-VITRECTOMY IN THE MANAGEMENT OF MALIGNANT GLAUCOMA IN PHAKIC EYES FOLLOWING TRABECULECTOMY. 61
27504696 2018
22
Combined Surgical Techniques for the Management of Malignant Glaucoma. 61
30595912 2018
23
Ocular Features of Cerebro-Costo-Mandibular Syndrome. 61
29117007 2018
24
OUTCOMES OF PARS PLANA VITRECTOMY IN THE MANAGEMENT OF REFRACTORY AQUEOUS MISDIRECTION SYNDROME. 61
28033233 2017
25
Aqueous misdirection masked as myopia after cataract surgery. 61
28774542 2017
26
Refractory aqueous misdirection syndrome: A possible complication of penetrating keratoplasty. 61
28318831 2017
27
Anterior segment approach for the surgical management of aqueous misdirection syndrome. 61
28823431 2017
28
Aqueous misdirection syndrome in persistent fetal vasculature (PFV). 61
28954029 2017
29
Incidence of short-term complications and associated factors after primary trabeculectomy in Chiang Mai University Hospital. 61
27905335 2016
30
Small eye - a small stump which can challenge and tilt a great surgery. 61
29450338 2016
31
Outcomes of 27 Gauge Microincision Vitrectomy Surgery for Posterior Segment Disease. 61
26429584 2016
32
Bilateral spontaneous aqueous misdirection: it can happen! 61
25998744 2015
33
Post-strabismus surgery aqueous misdirection syndrome. 61
26243745 2015
34
Surgical Management in a Patient With Complex Uveitic Glaucoma: A Case Report. 61
26252285 2015
35
Current concepts in the treatment of vitreous block, also known as aqueous misdirection. 61
25639795 2015
36
Recurrence of aqueous misdirection following pars plana vitrectomy in pseudophakic eyes. 61
25899512 2015
37
Aqueous misdirection syndrome: an interesting case presentation. 61
25678765 2015
38
Aqueous misdirection following pars plana vitrectomy and silicone oil injection. 61
26056429 2015
39
Misdirected aqueous flow in rhegmatogenous retinal detachment: a pathophysiology update. 61
25223495 2015
40
Acute aqueous misdirection syndrome: Pathophysiology and management. 61
25465700 2014
41
Aqueous misdirection in thyroid eye disease. 61
25414214 2014
42
Secondary glaucoma associated with bilateral complete ring cysts of the ciliary body. 61
25170979 2014
43
Efficacy and safety of a new surgical method to treat malignant glaucoma in pseudophakia. 61
24625375 2014
44
Medical management of acute ocular hypertension in a western screech owl (Megascops kennicottii). 61
24881152 2014
45
Spontaneous simultaneous bilateral malignant glaucoma of a patient with no antecedent history of medical or surgical eye diseases. 61
24920881 2014
46
Small eyes big problems: is cataract surgery the best option for the nanophthalmic eyes? 61
24034192 2013
47
An unusual presentation of aqueous misdirection. 61
23449517 2013
48
Outcomes of phacoemulsification and intraocular lens implantation in microphthalmos and nanophthalmos. 61
23245362 2013
49
Clinical Analysis of 50 Chinese Patients with Aqueous Misdirection Syndrome: a Retrospective Hospital-based Study. 61
22971510 2012
50
Outcomes of different management options for malignant glaucoma: a retrospective study. 61
21858468 2012

Variations for Aqueous Misdirection

Expression for Aqueous Misdirection

Search GEO for disease gene expression data for Aqueous Misdirection.

Pathways for Aqueous Misdirection

GO Terms for Aqueous Misdirection

Cellular components related to Aqueous Misdirection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acrosomal vesicle GO:0001669 8.62 LOXL1 HYAL3

Sources for Aqueous Misdirection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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