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MCID: AQS001
MIFTS: 23

Aqueous Misdirection

Categories: Eye diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Aqueous Misdirection

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MalaCards integrated aliases for Aqueous Misdirection:

Name: Aqueous Misdirection 12 15 71

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Eye diseases
See all MalaCards categories (disease lists)


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Disease Ontology 12 DOID:11149
ICD9CM 34 365.83
ICD10 32 H40.83
UMLS 71 C1135189
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Summaries for Aqueous Misdirection

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Disease Ontology : 12 A glaucoma characterized by shallowing of the central and peripheral anterior chamber from posterior pressure such that the intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Aqueous misdirection has symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Aqueous misdirection is caused by an abnormal relationsihp between the ciliary body, lens, and anterior vitreous such that aqueous flow is diverted into the posterior segment, leading to increased posterior pressure, which further closes the angle. Aqueous misdirection may occur in association with glaucoma surgery, trauma, endophthalmitis, and retinopathy of prematurity.

MalaCards based summary : Aqueous Misdirection is related to intraocular pressure quantitative trait locus and chronic closed-angle glaucoma, and has symptoms including progressive peripheral vision loss An important gene associated with Aqueous Misdirection is CTSA (Cathepsin A), and among its related pathways/superpathways are Lysosome and Glycosaminoglycan degradation. Affiliated tissues include eye, thyroid and endothelial.

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Related Diseases for Aqueous Misdirection

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Diseases related to Aqueous Misdirection via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 intraocular pressure quantitative trait locus 30.2 PEX19 CTSA
2 chronic closed-angle glaucoma 29.1 PEX19 NARF LAMA3 CTSA
3 cataract 10.4
4 retinal detachment 10.4
5 nanophthalmos 10.2
6 cycloplegia 10.2
7 open-angle glaucoma 10.2
8 corneal edema 10.2
9 primary angle-closure glaucoma 10.2
10 glaucoma, primary open angle 10.1
11 strabismus 10.1
12 persistent hyperplastic primary vitreous, autosomal recessive 10.1
13 joint laxity, short stature, and myopia 10.1
14 myopia 10.1
15 endophthalmitis 10.1
16 eye disease 10.1
17 ocular hypertension 10.1
18 mechanical strabismus 10.1
19 morgagni cataract 10.0 PEX19 LAMA3
20 mature cataract 10.0 PEX19 LAMA3
21 lens subluxation 9.9 PEX19 LAMA3
22 lens disease 9.9 PEX19 LAMA3
23 steroid-induced glaucoma 9.8 PRAC1 PEX19
24 acute closed-angle glaucoma 9.8 PEX19 LAMA3 CTSA
25 mucopolysaccharidosis-plus syndrome 9.8 SPAM1 CTSA
26 phacogenic glaucoma 9.4 PEX19 NARF LAMA3

Graphical network of the top 20 diseases related to Aqueous Misdirection:



Diseases related to Aqueous Misdirection
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Symptoms & Phenotypes for Aqueous Misdirection

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Symptoms:

12
  • • progressive peripheral vision loss
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Drugs & Therapeutics for Aqueous Misdirection

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Search Clinical Trials , NIH Clinical Center for Aqueous Misdirection

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Genetic Tests for Aqueous Misdirection

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Anatomical Context for Aqueous Misdirection

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MalaCards organs/tissues related to Aqueous Misdirection:

40
Eye, Thyroid, Endothelial
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Publications for Aqueous Misdirection

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Articles related to Aqueous Misdirection:

(show top 50) (show all 85)
# Title Authors PMID Year
1
Pars plana vitrectomy combined with irido-zonulo-hyaloidectomy for aqueous misdirection. 61
31466467 2020
2
Outcome and Complications of Combined Modified Deep Sclerectomy and Trabeculectomy for Surgical Management of Glaucoma: A Pilot Study. 61
32210532 2020
3
Bilateral aqueous misdirection syndrome after routine cataract surgery in angle closure. 61
31856996 2019
4
Intra-Operative Ostial Irido-Zonulo-Hyaloido-Vitrectomy with Primary Posterior Capsulectomy for Prevention of Post-Operative Aqueous Misdirection in Combined Phaco-Trabeculectomy in Primary Angle Closure Glaucoma. 61
31136195 2019
5
Management of recurrent aqueous misdirection by anterior segment surgeon after failed pars plana posterior vitrectomy. 61
31238466 2019
6
Unilateral Malignant Glaucoma Postbilateral Implantable Collamer Lens: Effect of Miotics. 61
31619910 2019
7
Successful recovery from misdirection syndrome in nanophthalmic eyes by performing an anterior vitrectomy through the anterior chamber. 61
29299722 2019
8
A Retrospective Study of 199 Xen45 Stent Implantations From 2014 to 2016. 61
30461555 2019
9
Management of Pseudophakic Malignant Glaucoma in Sunset Syndrome: A Case Report and Literature Review. 61
31263719 2019
10
RETINAL AND CHOROIDAL VASCULAR OCCLUSION FOLLOWING AQUEOUS MISDIRECTION SYNDROME IN A PATIENT WITH SICKLE CELL TRAIT. 61
28489705 2019
11
Prophylactic anterior vitrectomy during cataract surgery in eyes at increased risk for aqueous misdirection. 61
30148233 2018
12
Aqueous humor misdirection syndrome after glaucoma filtering surgery in patient with bilateral acute iris transillumination (BAIT) syndrome. 61
29853418 2018
13
Mini-vitrectomy; a Simple Solution to a Serious Condition. 61
30090177 2018
14
Spontaneous onset pseudophakic malignant glaucoma secondary to zonular weakness and cilio-lenticular block. 61
29930458 2018
15
Slit-lamp Needling of the Anterior Capsule for Aqueous Misdirection After Hyaloido-zonulectomy and Iridectomy. 61
29329140 2018
16
25G PARS PLANA VITRECTOMY AND IRIDO-ZONULO-HYALOIDO-VITRECTOMY IN THE MANAGEMENT OF MALIGNANT GLAUCOMA IN PHAKIC EYES FOLLOWING TRABECULECTOMY. 61
27504696 2018
17
Combined Surgical Techniques for the Management of Malignant Glaucoma. 61
30595912 2018
18
Ocular Features of Cerebro-Costo-Mandibular Syndrome. 61
29117007 2018
19
Acute and chronic fluid misdirection syndrome: pathophysiology and treatment. 61
29110086 2018
20
OUTCOMES OF PARS PLANA VITRECTOMY IN THE MANAGEMENT OF REFRACTORY AQUEOUS MISDIRECTION SYNDROME. 61
28033233 2017
21
Aqueous misdirection masked as myopia after cataract surgery. 61
28774542 2017
22
Refractory aqueous misdirection syndrome: A possible complication of penetrating keratoplasty. 61
28318831 2017
23
Anterior segment approach for the surgical management of aqueous misdirection syndrome. 61
28823431 2017
24
Aqueous misdirection syndrome in persistent fetal vasculature (PFV). 61
28954029 2017
25
Incidence of short-term complications and associated factors after primary trabeculectomy in Chiang Mai University Hospital. 61
27905335 2016
26
Small eye - a small stump which can challenge and tilt a great surgery. 61
29450338 2016
27
Outcomes of 27 Gauge Microincision Vitrectomy Surgery for Posterior Segment Disease. 61
26429584 2016
28
Bilateral spontaneous aqueous misdirection: it can happen! 61
25998744 2015
29
Post-strabismus surgery aqueous misdirection syndrome. 61
26243745 2015
30
Surgical Management in a Patient With Complex Uveitic Glaucoma: A Case Report. 61
26252285 2015
31
Current concepts in the treatment of vitreous block, also known as aqueous misdirection. 61
25639795 2015
32
Recurrence of aqueous misdirection following pars plana vitrectomy in pseudophakic eyes. 61
25899512 2015
33
Aqueous misdirection syndrome: an interesting case presentation. 61
25678765 2015
34
Misdirected aqueous flow in rhegmatogenous retinal detachment: a pathophysiology update. 61
25223495 2015
35
Aqueous misdirection following pars plana vitrectomy and silicone oil injection. 61
26056429 2015
36
Acute aqueous misdirection syndrome: Pathophysiology and management. 61
25465700 2014
37
Aqueous misdirection in thyroid eye disease. 61
25414214 2014
38
Secondary glaucoma associated with bilateral complete ring cysts of the ciliary body. 61
25170979 2014
39
Efficacy and safety of a new surgical method to treat malignant glaucoma in pseudophakia. 61
24625375 2014
40
Medical management of acute ocular hypertension in a western screech owl (Megascops kennicottii). 61
24881152 2014
41
Spontaneous simultaneous bilateral malignant glaucoma of a patient with no antecedent history of medical or surgical eye diseases. 61
24920881 2014
42
Small eyes big problems: is cataract surgery the best option for the nanophthalmic eyes? 61
24034192 2013
43
An unusual presentation of aqueous misdirection. 61
23449517 2013
44
Outcomes of phacoemulsification and intraocular lens implantation in microphthalmos and nanophthalmos. 61
23245362 2013
45
Clinical Analysis of 50 Chinese Patients with Aqueous Misdirection Syndrome: a Retrospective Hospital-based Study. 61
22971510 2012
46
Outcomes of different management options for malignant glaucoma: a retrospective study. 61
21858468 2012
47
Angle-closure glaucoma due to suprachoroidal hemorrhage secondary to disseminated intravascular coagulation. 61
21469966 2011
48
Ahmed glaucoma valves in refractory glaucoma: a 7-year audit. 61
19965829 2010
49
Cerulean fundus: an unexpected complication of cataract surgery in an eye with aqueous misdirection. 61
20576781 2010
50
Pars plana anterior vitrectomy, hyaloido-zonulectomy, and iridectomy for aqueous humor misdirection. 61
20609709 2010
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Variations for Aqueous Misdirection

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Expression for Aqueous Misdirection

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Search GEO for disease gene expression data for Aqueous Misdirection.
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Pathways for Aqueous Misdirection

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Pathways related to Aqueous Misdirection according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Lysosome 36
10.91 SPAM1 HYAL3 CTSA
2
Glycosaminoglycan degradation 36
Show member pathways
 10.26 SPAM1 HYAL3
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GO Terms for Aqueous Misdirection

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Molecular functions related to Aqueous Misdirection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity, acting on glycosyl bonds GO:0016798 8.96 SPAM1 HYAL3
2 hyalurononglucosaminidase activity GO:0004415 8.62 SPAM1 HYAL3
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Sources for Aqueous Misdirection

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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