MCID: ARC007
MIFTS: 39

Arachnoid Cysts

Categories: Endocrine diseases, Eye diseases, Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Arachnoid Cysts

MalaCards integrated aliases for Arachnoid Cysts:

Name: Arachnoid Cysts 54 74
Arachnoid Cyst 60 30 6
Intracranial Arachnoid Cysts 54 74
Arachnoid Cysts, Intracranial 54

Characteristics:

Orphanet epidemiological data:

60
arachnoid cyst
Inheritance: Autosomal recessive,Not applicable; Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:



External Ids:

MESH via Orphanet 46 D016080
ICD10 via Orphanet 35 G93.0
UMLS via Orphanet 75 C0078981
Orphanet 60 ORPHA2356

Summaries for Arachnoid Cysts

NINDS : 55 Arachnoid cysts are cerebrospinal fluid-filled sacs that are located between the brain or spinal cord and the arachnoid membrane, one of the three membranes that cover the brain and spinal cord.   Primary arachnoid cysts are present at birth and are the result of developmental abnormalities in the brain and spinal cord that arise during the early weeks of gestation.  Secondary arachnoid cysts are not as common as primary cysts and develop as a result of head injury, meningitis, or tumors, or as a complication of brain surgery.  The majority of arachnoid cysts form outside the temporal lobe of the brain in an area of the skull known as the middle cranial fossa.  Arachnoid cysts involving the spinal cord are rarer.  The location and size of the cyst determine the symptoms and when those symptoms begin.  Most individuals with arachnoid cysts develop symptoms before the age of 20, and especially during the first year of life, but some people with arachnoid cysts never have symptoms.  Males are four times more likely to have arachnoid cysts than females.  Typical symptoms of an arachnoid cyst around the brain include headache, nausea and vomiting, seizures, hearing and visual disturbances, vertigo, and difficulties with balance and walking.  Arachnoid cysts around the spinal cord compress the spinal cord or nerve roots and cause symptoms such as progressive back and leg pain and tingling or numbness in the legs or arms.  Diagnosis usually involves a brain scan or spine scan using diffusion-weighted MRI (magnetic resonance imaging) which helps distinguish fluid-filled arachnoid cysts from other types of cysts.   

MalaCards based summary : Arachnoid Cysts, also known as arachnoid cyst, is related to spinal intradural arachnoid cysts and tibia absent polydactyly arachnoid cyst. An important gene associated with Arachnoid Cysts is NRAS (NRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways is AGE-RAGE signaling pathway in diabetic complications. Affiliated tissues include spinal cord, brain and temporal lobe, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

NIH Rare Diseases : 54 Arachnoid cysts are sacs filled with cerebrospinal fluid (CSF) that are located between the brain or spinal cord and the arachnoid membrane, one of the three membranes that cover the brain and spinal cord. Arachnoid cysts can be primary or secondary. Primary arachnoid cysts are congenital (present at birth), resulting from abnormal development of the brain and spinal cord during early pregnancy. Secondary arachnoid cysts are less common, and result from head injuries, meningitis, tumors, or as a complication of brain surgery. Signs and symptoms depend on the location and size of the cyst and may include headache, nausea and vomiting, seizures, hearing and visual disturbances, vertigo, and difficulties with balance and walking. Although many affected individuals develop symptoms in the first year of life, some never develop symptoms. Whether and how to treat the condition depends on the location and size of the cyst. In some cases, arachnoid cysts are part of a genetic syndrome such as Chudley-McCullough syndrome, mucopolysaccharidosis, or Marfan syndrome, where there are many other associated signs and symptoms. When treatment is recommended, it may include placing a shunt to drain the fluid; surgically removing the cyst membranes; or opening the cyst so the fluid can drain into the CSF.

Wikipedia : 77 Arachnoid cysts are cerebrospinal fluid covered by arachnoidal cells and collagen that may develop... more...

Related Diseases for Arachnoid Cysts

Diseases related to Arachnoid Cysts via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 248)
# Related Disease Score Top Affiliating Genes
1 spinal intradural arachnoid cysts 12.7
2 tibia absent polydactyly arachnoid cyst 12.7
3 arachnoid cysts, intracranial 12.5
4 pachygyria with mental retardation, seizures, and arachnoid cysts 12.5
5 tibia, absence or hypoplasia of, with polydactyly, retrocerebellar arachnoid cyst, and other anomalies 12.3
6 intracranial cysts 11.7
7 melanosis, neurocutaneous 11.7
8 chudley-mccullough syndrome 11.6
9 dandy-walker complex 11.5
10 craniopharyngioma 11.5
11 acrocallosal syndrome 11.2
12 encephalocraniocutaneous lipomatosis 11.2
13 pachygyria-intellectual disability-epilepsy syndrome 11.2
14 hydrocephalus 10.6
15 syringomyelia 10.5
16 headache 10.4
17 congenital hydrocephalus 10.4
18 epilepsy 10.3
19 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
20 arachnoiditis 10.3
21 precocious puberty 10.3
22 trigeminal neuralgia 10.3
23 hydrocephalus, normal-pressure 10.3
24 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.2
25 kidney disease 10.2
26 polycystic kidney disease 10.2
27 schizophrenia 10.2
28 sensorineural hearing loss 10.2
29 autosomal dominant polycystic kidney disease 10.2
30 bobble-head doll syndrome 10.2
31 head injury 10.2
32 cauda equina syndrome 10.2
33 acoustic neuroma 10.2
34 obstructive hydrocephalus 10.2
35 cranial nerve palsy 10.2
36 neuropathy 10.2
37 intracranial hypertension 10.2
38 meningitis 10.2
39 tremor 10.2
40 epidermoid cysts 10.1
41 meningocele 10.1
42 facial paralysis 10.1
43 chiari malformation 10.1
44 hemifacial spasm 10.1
45 spondyloarthropathy 1 10.0
46 distichiasis 10.0
47 neural tube defects 10.0
48 spinal arachnoiditis 10.0
49 chiari malformation type ii 10.0
50 hydrocephalus, congenital, 1 10.0

Graphical network of the top 20 diseases related to Arachnoid Cysts:



Diseases related to Arachnoid Cysts

Symptoms & Phenotypes for Arachnoid Cysts

GenomeRNAi Phenotypes related to Arachnoid Cysts according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.23 SLC12A2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.23 NRAS
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.23 SLC12A2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.23 NRAS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.23 NRAS SLC12A2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.23 SLC12A2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.23 NRAS

MGI Mouse Phenotypes related to Arachnoid Cysts:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.26 COL4A1 FOXC2 NRAS SLC12A2
2 hearing/vestibular/ear MP:0005377 8.62 FOXC2 SLC12A2

Drugs & Therapeutics for Arachnoid Cysts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study and Surgical Treatment of Syringomyelia Completed NCT00011245

Search NIH Clinical Center for Arachnoid Cysts

Genetic Tests for Arachnoid Cysts

Genetic tests related to Arachnoid Cysts:

# Genetic test Affiliating Genes
1 Arachnoid Cyst 30

Anatomical Context for Arachnoid Cysts

MalaCards organs/tissues related to Arachnoid Cysts:

42
Spinal Cord, Brain, Temporal Lobe, Kidney, Bone, Pituitary, Myeloid

Publications for Arachnoid Cysts

Articles related to Arachnoid Cysts:

(show top 50) (show all 1662)
# Title Authors Year
1
Natural History of Intracranial Arachnoid Cysts. ( 30898748 )
2019
2
Microsurgical, endoscopic, and shunt management of pediatric temporosylvian arachnoid cysts: a comparative study. ( 30901748 )
2019
3
Prenatal diagnosis of arachnoid cysts: MRI features and neurodevelopmental outcome. ( 30927952 )
2019
4
Recurrent Caterpillar-like Arachnoid Cysts Following Initial Resection: A Unique Presentation of a Disorder Where the Limits of Modern Medicine Are Reached. ( 30937244 )
2019
5
Spinal Arachnoid Cysts: Presentation, management and pathophysiology. ( 30952036 )
2019
6
Retroclival Arachnoid Cysts: Case Series, Literature Review, and New Classification Proposal. ( 30315978 )
2019
7
Surgical Management of Spinal Arachnoid Cysts in Adults. ( 30447456 )
2019
8
A Review on the Effectiveness of Surgical Intervention for Symptomatic Intracranial Arachnoid Cysts in Adults. ( 30496927 )
2019
9
Neurocognitive profile in children with arachnoid cysts before and after surgical intervention. ( 30610479 )
2019
10
Familial arachnoid cysts: a review of 35 families. ( 30673833 )
2019
11
WNT1-associated osteogenesis imperfecta with atrophic frontal lobes and arachnoid cysts. ( 30692598 )
2019
12
Intracranial arachnoid cysts: Pediatric neurosurgery update. ( 30815323 )
2019
13
Psychopathological Influence of Middle Fossa Arachnoid Cysts in Young Men: Analysis of Korean Conscription Data. ( 30889776 )
2019
14
When the brain looks imperfect: An example of neuroplasticity as seen in a patient with arachnoid cysts - a case study. ( 30892127 )
2019
15
Bobble-Head Doll Syndrome in a Child with Suprasellar Arachnoid Cyst. ( 30746423 )
2019
16
Pupil-sparing third cranial nerve palsy with aberrant regeneration secondary to cavernous sinus arachnoid cyst. ( 30555949 )
2019
17
Case report: a novel mutation in ZIC2 in an infant with microcephaly, holoprosencephaly, and arachnoid cyst. ( 30855487 )
2019
18
Resolution of unilateral upper limb action tremor after surgical treatment of a contralateral frontoparietal arachnoid cyst. ( 30232669 )
2019
19
Cognitive disorders in a patient with an arachnoid cyst of the sylvian fissure and improvement after surgical treatment: Case description. ( 29111781 )
2019
20
Importance of Fenestration Size for Definitive Treatment of a Quadrigeminal Arachnoid Cyst: Endoscopic Inspection of the Cyst and Surrounding Anatomy: 2-Dimensional Operative Video. ( 29788188 )
2019
21
Is arachnoid cyst a static disease? A case report and literature review. ( 30209599 )
2019
22
Resection of an extensive thoracic arachnoid cyst via less-invasive targeted laminoplasties. ( 30332907 )
2019
23
Ventral Craniovertebral Junction Arachnoid Cyst in an Elderly Patient-A Case Report of a Unique Occurrence at Extremes of Age. ( 30472283 )
2019
24
Cerebral vasospasm after endoscopic fenestration of a temporal arachnoid cyst in a child-a case report and review of the literature. ( 30488234 )
2019
25
Cerebral Vasospasm after Open Fenestration of an Arachnoid Cyst in a 4-Year-Old Boy: Case Report and Review of the Literature. ( 30650412 )
2019
26
Utilizing real-time contrast medium to detect the fistula of giant spinal arachnoid cyst and treat with minimal invasive surgery. ( 30665385 )
2019
27
Treatment of a fourth ventricle arachnoid cyst via anterior hone of lateral ventricle using a flexible endoscope. ( 30677578 )
2019
28
Sellar and suprasellar arachnoid cyst. ( 30726308 )
2019
29
Rare Intrasellar Arachnoid Cyst Distinguishing From Other Benign Cystic Lesions and its Surgical Strategies. ( 30865114 )
2019
30
Short report on a rare presentation of temporal arachnoid cyst and lessons learned. ( 30885870 )
2019
31
Symptomatic extradural spinal arachnoid cyst: More than a simple herniated sac. ( 31000984 )
2019
32
Symptomatic Thoracic Intramedullary Arachnoid Cyst: "A Rare Entity" Report of Two Cases with Short Review of Literature. ( 31001022 )
2019
33
Intracranial arachnoid cyst rupture after mild TBI in children: have we underestimated this risk? ( 31040140 )
2019
34
Does subjective improvement in adults with intracranial arachnoid cysts justify surgical treatment? ( 28298013 )
2018
35
Spontaneous Repeated Disappearance and Recurrence of Multiple Spinal Intradural Arachnoid Cysts in a Child. ( 29325964 )
2018
36
The Transcondylar Approach to Access Symptomatic Arachnoid Cysts of the Hypoglossal Canal. ( 29351690 )
2018
37
Development of Neuromyelitis Optica Spectrum Disorder and Spinal Arachnoid Cysts in a Patient With Intractable Epilepsy. ( 29379967 )
2018
38
Hemorrhagic Complications of Arachnoid Cysts: When, Why, and Who? ( 29410376 )
2018
39
Spinal arachnoid cysts in adults: diagnosis and management. A single-center experience. ( 30265227 )
2018
40
Arachnoid cysts of the internal auditory canal: An underappreciated entity? ( 30537076 )
2018
41
Familial intracranial arachnoid cysts with a missense mutation (c.2576C > T) in RERE: A case report. ( 30558068 )
2018
42
Clinical and radiological outcomes following surgical treatment for intra-cranial arachnoid cysts. ( 30599313 )
2018
43
Glimpse into Pathophysiology of Sellar Arachnoid Cysts. ( 30149172 )
2018
44
Chronic Subdural Hematoma Associated with Congenital Arachnoid Cysts: Management Dilemmas. ( 29974007 )
2018
45
Arachnoid cysts with spontaneous intracystic hemorrhage and associated subdural hematoma: Report of management and follow-up of 2 cases. ( 29904503 )
2018
46
Arachnoid cysts and subdural hygroma. ( 29891233 )
2018
47
Management of Arachnoid Cysts: A Comprehensive Review. ( 29888162 )
2018
48
Evaluation of the Communication Between Arachnoid Cysts and Neighboring Cerebrospinal Fluid Spaces by T2W 3D-SPACE With Variant Flip-Angle Technique at 3 T. ( 29787500 )
2018
49
Surgical Management of Giant Retrocerebellar Arachnoid Cysts with a Cystoventricular Stent After Long-Term, Independent, and Simultaneous Intracystic and Intraventricular Pressure Monitoring. ( 29625307 )
2018
50
Neurodevelopmental outcomes in children with large temporal arachnoid cysts. ( 29521605 )
2018

Variations for Arachnoid Cysts

ClinVar genetic disease variations for Arachnoid Cysts:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 46;XY;t(2;11)(q31;q13.5)pat Translocation Uncertain significance

Copy number variations for Arachnoid Cysts from CNVD:

7 (show all 32)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 41643 10 21822848 21949193 Loss C10orf114 Intracranial arachnoid cysts
2 41644 10 21822848 21949193 Loss C10orf140 Intracranial arachnoid cysts
3 41645 10 21822848 21949193 Loss MLLT10 Intracranial arachnoid cysts
4 57050 11 62557724 62669857 Loss SLC22A24 Intracranial arachnoid cysts
5 63865 12 121446657 121547275 Copy number CLIP1 Intracranial arachnoid cysts
6 63866 12 121446657 121547275 Copy number ZCCHC8 Intracranial arachnoid cysts
7 68816 12 51724073 51844567 Loss CSAD Intracranial arachnoid cysts
8 68817 12 51724073 51844567 Loss IGFBP6 Intracranial arachnoid cysts
9 68818 12 51724073 51844567 Loss SOAT2 Intracranial arachnoid cysts
10 68819 12 51724073 51844567 Loss SPRYD3 Intracranial arachnoid cysts
11 68820 12 51724073 51844567 Loss TENC1 Intracranial arachnoid cysts
12 70825 12 64978487 65093419 Gain ITGB7 Intracranial arachnoid cysts
13 70828 12 64978487 65093419 Gain ZNF740 Intracranial arachnoid cysts
14 86768 14 64978487 65093419 Inversion FUT8 Intracranial arachnoid cysts
15 92669 15 42468491 42598658 Copy number CASC4 Intracranial arachnoid cysts
16 92670 15 42468491 42598658 Copy number CTDSPL2 Intracranial arachnoid cysts
17 101220 16 3431656 3522375 Copy number C16orf90 Intracranial arachnoid cysts
18 101221 16 3431656 3522375 Copy number CLUAP1 Intracranial arachnoid cysts
19 101380 16 3522375 3631656 Loss BTBD12 Intracranial arachnoid cysts
20 101382 16 3522375 3631656 Loss NLRC3 Intracranial arachnoid cysts
21 106726 17 1 10700000 Loss TP53 Intracranial arachnoid cysts
22 112317 17 38560627 38814457 Loss LOC100130581 Intracranial arachnoid cysts
23 112318 17 38560627 38814457 Loss NBR1 Intracranial arachnoid cysts
24 112319 17 38560627 38814457 Loss TMEM106A Intracranial arachnoid cysts
25 124820 19 1205797 1228434 Loss STK11 Intracranial arachnoid cysts
26 125526 19 14246734 14391382 Loss CD97 Intracranial arachnoid cysts
27 125527 19 14246734 14391382 Loss DDX39 Intracranial arachnoid cysts
28 227152 7 6498207 6600621 Deletion C7orf26 Intracranial arachnoid cysts
29 227153 7 6498207 6600621 Deletion GRID2IP Intracranial arachnoid cysts
30 227154 7 6498207 6600621 Deletion ZDHHC4 Intracranial arachnoid cysts
31 233699 8 12700000 19000000 Loss N33 Intracranial arachnoid cysts
32 239856 8 42175206 42281148 Copy number PLAT Intracranial arachnoid cysts

Expression for Arachnoid Cysts

Search GEO for disease gene expression data for Arachnoid Cysts.

Pathways for Arachnoid Cysts

Pathways related to Arachnoid Cysts according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.62 COL4A1 NRAS

GO Terms for Arachnoid Cysts

Biological processes related to Arachnoid Cysts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 branching involved in blood vessel morphogenesis GO:0001569 8.62 COL4A1 FOXC2

Sources for Arachnoid Cysts

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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