MCID: ARC007
MIFTS: 42

Arachnoid Cysts

Categories: Endocrine diseases, Eye diseases, Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Arachnoid Cysts

MalaCards integrated aliases for Arachnoid Cysts:

Name: Arachnoid Cysts 53 73
Arachnoid Cyst 59 29 6
Intracranial Arachnoid Cysts 53 73
Arachnoid Cysts, Intracranial 53

Characteristics:

Orphanet epidemiological data:

59
arachnoid cyst
Inheritance: Autosomal recessive,Not applicable; Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:



External Ids:

Orphanet 59 ORPHA2356
UMLS via Orphanet 74 C0078981
MESH via Orphanet 45 D016080
ICD10 via Orphanet 34 G93.0

Summaries for Arachnoid Cysts

NINDS : 54 Arachnoid cysts are cerebrospinal fluid-filled sacs that are located between the brain or spinal cord and the arachnoid membrane, one of the three membranes that cover the brain and spinal cord.   Primary arachnoid cysts are present at birth and are the result of developmental abnormalities in the brain and spinal cord that arise during the early weeks of gestation.  Secondary arachnoid cysts are not as common as primary cysts and develop as a result of head injury, meningitis, or tumors, or as a complication of brain surgery.  The majority of arachnoid cysts form outside the temporal lobe of the brain in an area of the skull known as the middle cranial fossa.  Arachnoid cysts involving the spinal cord are rarer.  The location and size of the cyst determine the symptoms and when those symptoms begin.  Most individuals with arachnoid cysts develop symptoms before the age of 20, and especially during the first year of life, but some people with arachnoid cysts never have symptoms.  Males are four times more likely to have arachnoid cysts than females.  Typical symptoms of an arachnoid cyst around the brain include headache, nausea and vomiting, seizures, hearing and visual disturbances, vertigo, and difficulties with balance and walking.  Arachnoid cysts around the spinal cord compress the spinal cord or nerve roots and cause symptoms such as progressive back and leg pain and tingling or numbness in the legs or arms.  Diagnosis usually involves a brain scan or spine scan using diffusion-weighted MRI (magnetic resonance imaging) which helps distinguish fluid-filled arachnoid cysts from other types of cysts.   

MalaCards based summary : Arachnoid Cysts, also known as arachnoid cyst, is related to spinal intradural arachnoid cysts and tibia absent polydactyly arachnoid cyst. An important gene associated with Arachnoid Cysts is NRAS (NRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways is AGE-RAGE signaling pathway in diabetic complications. Affiliated tissues include spinal cord, brain and temporal lobe, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

NIH Rare Diseases : 53 Arachnoid cysts are sacs filled with cerebrospinal fluid (CSF) that are located between the brain or spinal cord and the arachnoid membrane, one of the three membranes that cover the brain and spinal cord. Arachnoid cysts can be primary or secondary. Primary arachnoid cysts are congenital (present at birth), resulting from abnormal development of the brain and spinal cord during early pregnancy. Secondary arachnoid cysts are less common, and result from head injuries, meningitis, tumors, or as a complication of brain surgery. Signs and symptoms depend on the location and size of the cyst and may include headache, nausea and vomiting, seizures, hearing and visual disturbances, vertigo, and difficulties with balance and walking. Although many affected individuals develop symptoms in the first year of life, some never develop symptoms. Whether and how to treat the condition depends on the location and size of the cyst. In some cases, arachnoid cysts are part of a genetic syndrome such as Chudley-McCullough syndrome, mucopolysaccharidosis, or Marfan syndrome, where there are many other associated signs and symptoms. When treatment is recommended, it may include placing a shunt to drain the fluid; surgically removing the cyst membranes; or opening the cyst so the fluid can drain into the CSF.

Wikipedia : 76 Arachnoid cysts are cerebrospinal fluid covered by arachnoidal cells and collagen that may develop... more...

Related Diseases for Arachnoid Cysts

Diseases related to Arachnoid Cysts via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
# Related Disease Score Top Affiliating Genes
1 spinal intradural arachnoid cysts 12.7
2 tibia absent polydactyly arachnoid cyst 12.6
3 arachnoid cysts, intracranial 12.5
4 pachygyria with mental retardation, seizures, and arachnoid cysts 12.4
5 tibia, absence or hypoplasia of, with polydactyly, retrocerebellar arachnoid cyst, and other anomalies 12.3
6 intracranial cysts 11.7
7 melanosis, neurocutaneous 11.6
8 chudley-mccullough syndrome 11.6
9 retrocerebellar cyst 11.6
10 dandy-walker complex 11.5
11 craniopharyngioma 11.5
12 acrocallosal syndrome 11.1
13 encephalocraniocutaneous lipomatosis 11.1
14 pachygyria-intellectual disability-epilepsy syndrome 11.1
15 hydrocephalus 10.5
16 syringomyelia 10.5
17 headache 10.4
18 epilepsy 10.3
19 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
20 arachnoiditis 10.3
21 precocious puberty 10.3
22 trigeminal neuralgia 10.3
23 hydrocephalus, normal-pressure 10.2
24 polycystic kidney disease 10.2
25 kidney disease 10.2
26 schizophrenia 10.2
27 sensorineural hearing loss 10.2
28 autosomal dominant polycystic kidney disease 10.2
29 head injury 10.2
30 cauda equina syndrome 10.1
31 obstructive hydrocephalus 10.1
32 cranial nerve palsy 10.1
33 neuropathy 10.1
34 intracranial hypertension 10.1
35 meningitis 10.1
36 bobble-head doll syndrome 10.1
37 tremor 10.1
38 epidermoid cysts 10.1
39 meningocele 10.1
40 facial paralysis 10.1
41 chiari malformation 10.1
42 hemifacial spasm 10.1
43 spondyloarthropathy 1 10.0
44 distichiasis 10.0
45 neural tube defects 10.0
46 spinal arachnoiditis 10.0
47 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.0
48 lymphedema 10.0
49 quadriplegia 10.0
50 kallmann syndrome 10.0

Graphical network of the top 20 diseases related to Arachnoid Cysts:



Diseases related to Arachnoid Cysts

Symptoms & Phenotypes for Arachnoid Cysts

GenomeRNAi Phenotypes related to Arachnoid Cysts according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.23 SLC12A2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.23 NRAS
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.23 SLC12A2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.23 NRAS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.23 NRAS SLC12A2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.23 SLC12A2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.23 NRAS

MGI Mouse Phenotypes related to Arachnoid Cysts:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.26 COL4A1 FOXC2 NRAS SLC12A2
2 hearing/vestibular/ear MP:0005377 8.8 FOXC2 SLC12A2 SPAST

Drugs & Therapeutics for Arachnoid Cysts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study and Surgical Treatment of Syringomyelia Completed NCT00011245

Search NIH Clinical Center for Arachnoid Cysts

Genetic Tests for Arachnoid Cysts

Genetic tests related to Arachnoid Cysts:

# Genetic test Affiliating Genes
1 Arachnoid Cyst 29

Anatomical Context for Arachnoid Cysts

MalaCards organs/tissues related to Arachnoid Cysts:

41
Spinal Cord, Brain, Temporal Lobe, Kidney, Bone, Pituitary, B Cells

Publications for Arachnoid Cysts

Articles related to Arachnoid Cysts:

(show top 50) (show all 1581)
# Title Authors Year
1
Pupil-sparing third cranial nerve palsy with aberrant regeneration secondary to cavernous sinus arachnoid cyst. ( 30555949 )
2019
2
Temporal arachnoid cysts: are they congenital? ( 29046949 )
2018
3
Arachnoid cysts and subdural hygroma. ( 29891233 )
2018
4
Chronic Subdural Hematoma Associated with Congenital Arachnoid Cysts: Management Dilemmas. ( 29974007 )
2018
5
Evaluation of the Communication Between Arachnoid Cysts and Neighboring Cerebrospinal Fluid Spaces by T2W 3D-SPACE With Variant Flip-Angle Technique at 3 T. ( 29787500 )
2018
6
Neurodevelopmental outcomes in children with large temporal arachnoid cysts. ( 29521605 )
2018
7
Rare Case of Tricompartmental Arachnoid Cyst Spanning Infratentorial, Supratentorial, and Extracranial Compartment and Presenting as Posterior Parietal Meningocele. ( 29698795 )
2018
8
Spontaneous repeated disappearance and recurrence of multiple spinal intradural arachnoid cysts in a child. ( 29325964 )
2018
9
Surgical Management of Giant Retrocerebellar Arachnoid Cysts with a Cystoventricular Stent After Long-Term, Independent, and Simultaneous Intracystic and Intraventricular Pressure Monitoring. ( 29625307 )
2018
10
Arachnoid cysts with spontaneous intracystic hemorrhage and associated subdural hematoma: Report of management and follow-up of 2 cases. ( 29904503 )
2018
11
Surgical management of cerebellopontine angle arachnoid cysts associated with hearing deficit in pediatric patients. ( 29171799 )
2018
12
Management of Arachnoid Cysts: A Comprehensive Review. ( 29888162 )
2018
13
Hemorrhagic complications of arachnoid cysts: When, Why and Who? ( 29410376 )
2018
14
Clinical and radiological features of spinal extradural arachnoid cysts: Valve-like mechanism involving the nerve root fiber as a possible cause of cyst expansion. ( 29452792 )
2018
15
The Transcondylar Approach to Access Symptomatic Arachnoid Cysts of the Hypoglossal Canal. ( 29351690 )
2018
16
Development of Neuromyelitis Optica Spectrum Disorder and Spinal Arachnoid Cysts in a Patient With Intractable Epilepsy. ( 29379967 )
2018
17
Glimpse into Pathophysiology of Sellar Arachnoid Cysts. ( 30149172 )
2018
18
Spinal arachnoid cysts in adults: diagnosis and management. A single-center experience. ( 30265227 )
2018
19
Retroclival Arachnoid Cysts: Case Series, Literature Review, and New Classification Proposal. ( 30315978 )
2018
20
Surgical Management of Spinal Arachnoid Cysts in Adults. ( 30447456 )
2018
21
A review on the effectiveness of surgical intervention for symptomatic intracranial arachnoid cysts in adults. ( 30496927 )
2018
22
Arachnoid cysts of the internal auditory canal: An underappreciated entity? ( 30537076 )
2018
23
Endoscopic fenestration of a posterior fossa arachnoid cyst to treat a Chiari-like headache. ( 29327862 )
2018
24
A novel duraplasty technique following fenestration of a massive lumbar arachnoid cyst in a patient with scoliosis: technical case report. ( 29219781 )
2018
25
Surgical treatment of a thoracic ventral intradural arachnoid cyst associated with syringomyelia: case report. ( 30497153 )
2018
26
Posterior fossa arachnoid cyst causing torticollis and gastro-oesophageal reflux in an infant. ( 30062591 )
2018
27
Resolution of unilateral upper limb action tremor after surgical treatment of a contralateral frontoparietal arachnoid cyst. ( 30232669 )
2018
28
A screening method to distinguish syndromic from sporadic spinal extradural arachnoid cyst. ( 29459084 )
2018
29
Spinal Extradural Arachnoid Cyst: Significance of Intrathecal Infusion after Fistula Closure. ( 29463942 )
2018
30
Simultaneous bone remodeling and surgical decompression of large Sylvian arachnoid cyst. ( 29464388 )
2018
31
Microvascular Decompression and Arachnoid Cyst Fenestration for Treatment of Medulla Oblongata Compression Caused by Arachnoid Cyst-Vascular Loop Complex. ( 29486311 )
2018
32
Nontraumatic Subdural Hematoma and Intracystic Hemorrhage Associated with a Middle Fossa Arachnoid Cyst. ( 29492139 )
2018
33
Pure Endoscopic Management of Fourth Ventricle Arachnoid Cyst: Case Report and Literature Review. ( 29492157 )
2018
34
Rare case of a rapidly enlarging symptomatic arachnoid cyst of the posterior fossa in an infant: A case report and review of the literature. ( 29576908 )
2018
35
Extradural Arachnoid Cyst Excision. ( 29578874 )
2018
36
Enlarging Temporal Arachnoid Cyst Extending Inside the Sphenoid Sinus. ( 29597017 )
2018
37
Subdural hygroma secondary to rupture of an intracranial arachnoid cyst: description of 2cases and review of the literature. ( 29627291 )
2018
38
Bilateral Temporal Extradural Hematoma on Top of Bilateral Temporal Arachnoid Cyst: First Case Report and Extensive Literature Review. ( 29673818 )
2018
39
A Rare Case of Spinal Extradural Arachnoid Cyst with Cord Compression. ( 29682063 )
2018
40
Giant left parietal lobe arachnoid cyst presenting as early-onset dementia. ( 29776944 )
2018
41
Surgically Treated de Novo Cervicomedullary Arachnoid Cyst in Symptomatic Adult Patient. ( 29777892 )
2018
42
Importance of Fenestration Size for Definitive Treatment of a Quadrigeminal Arachnoid Cyst: Endoscopic Inspection of the Cyst and Surrounding Anatomy: 2-Dimensional Operative Video. ( 29788188 )
2018
43
Electromagnetic navigation-guided neuroendoscopic transfrontal transaqueductal fenestration of expansive posterior fossa arachnoid cyst with simultaneous endoscopic third ventriculostomy in an infant. ( 29846773 )
2018
44
Rare Case of Convexity Meningioma Growing into Arachnoid Cyst. ( 29913293 )
2018
45
Arachnoid Cyst Causing Depression and Neuropsychiatric Symptoms: a Case Report. ( 29921743 )
2018
46
Endoscopic cystoventriculostomy of an arachnoid cyst using a neuroendovascular stent to maintain patency. ( 29950125 )
2018
47
Nontraumatic intradiploic arachnoid cyst of the sphenoid bone. ( 29988779 )
2018
48
Postarachnoiditis Anterior Spinal Arachnoid Cyst Formation with Compressive Myelopathy: Report of 2 Cases. ( 30017769 )
2018
49
Pediatric Symptomatic Sacral Extradural Arachnoid Cyst: Surgical Management Review. ( 30090139 )
2018
50
Spontaneous Spinal Subarachnoid Hemorrhage with Development of an Arachnoid Cyst-A Case Report and Review of the Literature. ( 30149166 )
2018

Variations for Arachnoid Cysts

Copy number variations for Arachnoid Cysts from CNVD:

7 (show all 32)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 41643 10 21822848 21949193 Loss C10orf114 Intracranial arachnoid cysts
2 41644 10 21822848 21949193 Loss C10orf140 Intracranial arachnoid cysts
3 41645 10 21822848 21949193 Loss MLLT10 Intracranial arachnoid cysts
4 57050 11 62557724 62669857 Loss SLC22A24 Intracranial arachnoid cysts
5 63865 12 121446657 121547275 Copy number CLIP1 Intracranial arachnoid cysts
6 63866 12 121446657 121547275 Copy number ZCCHC8 Intracranial arachnoid cysts
7 68816 12 51724073 51844567 Loss CSAD Intracranial arachnoid cysts
8 68817 12 51724073 51844567 Loss IGFBP6 Intracranial arachnoid cysts
9 68818 12 51724073 51844567 Loss SOAT2 Intracranial arachnoid cysts
10 68819 12 51724073 51844567 Loss SPRYD3 Intracranial arachnoid cysts
11 68820 12 51724073 51844567 Loss TENC1 Intracranial arachnoid cysts
12 70825 12 64978487 65093419 Gain ITGB7 Intracranial arachnoid cysts
13 70828 12 64978487 65093419 Gain ZNF740 Intracranial arachnoid cysts
14 86768 14 64978487 65093419 Inversion FUT8 Intracranial arachnoid cysts
15 92669 15 42468491 42598658 Copy number CASC4 Intracranial arachnoid cysts
16 92670 15 42468491 42598658 Copy number CTDSPL2 Intracranial arachnoid cysts
17 101220 16 3431656 3522375 Copy number C16orf90 Intracranial arachnoid cysts
18 101221 16 3431656 3522375 Copy number CLUAP1 Intracranial arachnoid cysts
19 101380 16 3522375 3631656 Loss BTBD12 Intracranial arachnoid cysts
20 101382 16 3522375 3631656 Loss NLRC3 Intracranial arachnoid cysts
21 106726 17 1 10700000 Loss TP53 Intracranial arachnoid cysts
22 112317 17 38560627 38814457 Loss LOC100130581 Intracranial arachnoid cysts
23 112318 17 38560627 38814457 Loss NBR1 Intracranial arachnoid cysts
24 112319 17 38560627 38814457 Loss TMEM106A Intracranial arachnoid cysts
25 124820 19 1205797 1228434 Loss STK11 Intracranial arachnoid cysts
26 125526 19 14246734 14391382 Loss CD97 Intracranial arachnoid cysts
27 125527 19 14246734 14391382 Loss DDX39 Intracranial arachnoid cysts
28 227152 7 6498207 6600621 Deletion C7orf26 Intracranial arachnoid cysts
29 227153 7 6498207 6600621 Deletion GRID2IP Intracranial arachnoid cysts
30 227154 7 6498207 6600621 Deletion ZDHHC4 Intracranial arachnoid cysts
31 233699 8 12700000 19000000 Loss N33 Intracranial arachnoid cysts
32 239856 8 42175206 42281148 Copy number PLAT Intracranial arachnoid cysts

Expression for Arachnoid Cysts

Search GEO for disease gene expression data for Arachnoid Cysts.

Pathways for Arachnoid Cysts

Pathways related to Arachnoid Cysts according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.62 COL4A1 NRAS

GO Terms for Arachnoid Cysts

Biological processes related to Arachnoid Cysts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 branching involved in blood vessel morphogenesis GO:0001569 8.62 COL4A1 FOXC2

Sources for Arachnoid Cysts

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....