Arachnoiditis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ARC002 MIFTS: 46	Arachnoiditis Categories: Genetic diseases, Nephrological diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Arachnoiditis

MalaCards integrated aliases for Arachnoiditis:

Name: Arachnoiditis ¹² ⁷⁷ ⁵⁴ ⁴⁵ ¹⁵ ⁷⁴

Familial Spinal Arachnoiditis ⁷⁴

Spinal Arachnoiditis ⁵⁴

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Neuronal diseases Nephrological diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the nervous system

Inflammatory diseases of the central nervous system

Meningitis due to other and unspecified causes

External Ids:

Disease Ontology ¹² DOID:12156

MeSH ⁴⁵ D001100

NCIt ⁵¹ C37913

SNOMED-CT ⁶⁹ 8217007

ICD10 ³⁴ G03

UMLS ⁷⁴ C0003708 C1710146

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Summaries for Arachnoiditis

NIH Rare Diseases : ⁵⁴ Arachnoiditis is a pain disorder caused by inflammation of the arachnoid, one of the membranes that surrounds and protects the nerves of the spinal cord. The inflammation may occur due to irritation from chemicals; infection; direct injury to the spine; chronic compression of spinal nerves; or complications from spinal surgery or other spinal procedures. It may result in scar tissue and adhesions, which cause the spinal nerves to �??stick�?� together. If arachnoiditis affects the function of nerves, it can cause symptoms such as numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs. In some people. it may affect the bladder, bowel, and sexual function. Very severe arachnoiditis can result in paralysis of the legs. Treatment aims to relieve pain and improve symptoms that impair function. Treatment may include pain medications, physical therapy, and psychotherapy. Surgical treatment is controversial because it offers only short-term relief and may increase formation of scar tissue.

MalaCards based summary : Arachnoiditis, also known as familial spinal arachnoiditis, is related to glossopharyngeal neuralgia and arachnoid cysts. An important gene associated with Arachnoiditis is ACAA1 (Acetyl-CoA Acyltransferase 1). The drugs Bupivacaine and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related phenotypes are muscle weakness and hearing impairment

NINDS : ⁵⁵ Arachnoiditis is caused by the inflammation of the arachnoid, one of the membranes that surround and protect the nerves of the spinal cord. The arachnoid can become inflamed because of an irritation from chemicals, infection from bacteria or viruses, as the result of direct injury to the spine, chronic compression of spinal nerves, or complications from spinal surgery or other invasive spinal procedures. Inflammation can sometimes lead to the formation of scar tissue and adhesions, which cause the spinal nerves to “stick” together. If arachnoiditis begins to interfere with the function of one or more of these nerves, it can cause a number of symptoms, including chronic and persistent pain, numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs. Some people with arachnoiditis will have debilitating muscle cramps, twitches, or spasms. It may also affect bladder, bowel, and sexual function. In severe cases, arachnoiditis may cause paralysis of the lower limbs.

Wikipedia : ⁷⁷ Arachnoiditis is an inflammatory condition of the arachnoid mater or ''arachnoid'', one of the membranes... more...

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Related Diseases for Arachnoiditis

Diseases related to Arachnoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 310)

#	Related Disease	Score	Top Affiliating Genes
1	glossopharyngeal neuralgia	29.0	CRLF1 POMC
2	arachnoid cysts	12.8
3	spinal intradural arachnoid cysts	12.5
4	tibia absent polydactyly arachnoid cyst	12.5
5	spinal arachnoiditis	12.4
6	arachnoid cysts, intracranial	12.3
7	pachygyria with mental retardation, seizures, and arachnoid cysts	12.3
8	tibia, absence or hypoplasia of, with polydactyly, retrocerebellar arachnoid cyst, and other anomalies	12.1
9	syringomyelia	11.5
10	intracranial cysts	11.5
11	melanosis, neurocutaneous	11.5
12	meningioma, familial	11.5
13	chudley-mccullough syndrome	11.4
14	meningitis	11.4
15	craniopharyngioma	11.3
16	dandy-walker complex	11.3
17	amyloidosis, hereditary, transthyretin-related	11.0
18	polycystic kidney disease 1 with or without polycystic liver disease	11.0
19	syringomyelia, noncommunicating isolated	11.0
20	acrocallosal syndrome	11.0
21	encephalocraniocutaneous lipomatosis	11.0
22	pachygyria-intellectual disability-epilepsy syndrome	11.0
23	tarlov cysts	11.0
24	hydrocephalus	10.5
25	headache	10.3
26	tuberculous meningitis	10.2
27	cauda equina syndrome	10.2
28	intracranial hypertension	10.2
29	ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus	10.2
30	epilepsy	10.2
31	precocious puberty	10.1
32	spondyloarthropathy 1	10.1
33	trigeminal neuralgia	10.1
34	spondylitis	10.1
35	hydrocephalus, normal-pressure	10.1
36	neuropathy	10.1
37	polycystic kidney disease	10.0
38	sensorineural hearing loss	10.0
39	communicating hydrocephalus	10.0
40	kidney disease	10.0
41	chiari malformation	10.0
42	congenital hydrocephalus	10.0
43	glioma	10.0
44	schizophrenia	10.0
45	congenital heart defects, hamartomas of tongue, and polysyndactyly	10.0
46	spinal meningioma	10.0
47	acoustic neuroma	10.0
48	paraplegia	10.0
49	adenoma	10.0
50	autosomal dominant polycystic kidney disease	10.0

Graphical network of the top 20 diseases related to Arachnoiditis:

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Symptoms & Phenotypes for Arachnoiditis

Human phenotypes related to Arachnoiditis:

³³ (show all 13)

#	Description	HPO Frequency	HPO Source Accession
1	muscle weakness ³³	hallmark (90%)	HP:0001324
2	hearing impairment ³³	hallmark (90%)	HP:0000365
3	abnormality of vision ³³	hallmark (90%)	HP:0000504
4	arthralgia ³³	hallmark (90%)	HP:0002829
5	paresthesia ³³	hallmark (90%)	HP:0003401
6	meningitis ³³	hallmark (90%)	HP:0001287
7	hyporeflexia ³³	hallmark (90%)	HP:0001265
8	tinnitus ³³	hallmark (90%)	HP:0000360
9	anhidrosis ³³	frequent (33%)	HP:0000970
10	hydrocephalus ³³	occasional (7.5%)	HP:0000238
11	fatigue ³³	occasional (7.5%)	HP:0012378
12	urinary bladder sphincter dysfunction ³³	occasional (7.5%)	HP:0002839
13	migraine ³³	occasional (7.5%)	HP:0002076

GenomeRNAi Phenotypes related to Arachnoiditis according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-150	9.56	TFG
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-175	9.56	ACAA1
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-20	9.56	ACAA1
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-34	9.56	TFG
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-40	9.56	TFG
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-48	9.56	ACAA1 TFG
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-71	9.56	ACAA1
8	Increased transferrin (TF) endocytosis	GR00363-A	9.02	ACAA1 CRLF1 HSF4 MRI1 POMC

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Drugs & Therapeutics for Arachnoiditis

Drugs for Arachnoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Bupivacaine

Approved, Investigational

Phase 4

2180-92-9, 38396-39-3

2474

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4

1177-87-3

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4

50-02-2

5743

Central Nervous System Depressants

Phase 4

Peripheral Nervous System Agents

Phase 4

Anti-Inflammatory Agents

Phase 4

HIV Protease Inhibitors

Phase 4

Hormones

Phase 4

protease inhibitors

Phase 4

Autonomic Agents

Phase 4

BB 1101

Phase 4

Anesthetics

Phase 4

Anesthetics, Local

Phase 4

Antineoplastic Agents, Hormonal

Phase 4

Hormone Antagonists

Phase 4

Antiemetics

Phase 4

Gastrointestinal Agents

Phase 4

glucocorticoids

Phase 4

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4

Carmustine

Approved, Investigational

Phase 2

154-93-8

2578

Ifosfamide

Approved

Phase 2

3778-73-2

3690

Methotrexate

Approved

Phase 2

1959-05-2, 59-05-2

126941

Carboplatin

Approved

Phase 2

41575-94-4

38904 10339178 498142

Clonazepam

Approved, Illicit

Phase 2

1622-61-3

2802

Hydrocortisone acetate

Approved, Vet_approved

Phase 2

50-03-3

Busulfan

Approved, Investigational

Phase 2

55-98-1

2478

Etoposide

Approved

Phase 2

33419-42-0

36462

Mechlorethamine

Approved, Investigational

Phase 2

51-75-2

4033

Cytarabine

Approved, Experimental, Investigational

Phase 2

147-94-4, 65-46-3

6253

Hydrocortisone

Approved, Vet_approved

Phase 2

50-23-7

5754

rituximab

Approved

Phase 2

174722-31-7

10201696

Thiotepa

Approved, Investigational

Phase 2

52-24-4

5453

leucovorin

Approved

Phase 2

58-05-9

6006 143

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 2

59-30-3

6037

Immunologic Factors

Phase 2

Immunosuppressive Agents

Phase 2

Anti-Infective Agents

Phase 2

Anti-Bacterial Agents

Phase 2

Angiogenesis Modulating Agents

Phase 2

Angiogenesis Inhibitors

Phase 2

Hydrocortisone 17-butyrate 21-propionate

Phase 2

Isophosphamide mustard

Phase 2

Antineoplastic Agents, Alkylating

Phase 2

Antiviral Agents

Phase 2

Vitamin B Complex

Phase 2

Antimetabolites

Phase 2

Antineoplastic Agents, Immunological

Phase 2

Etoposide phosphate

Phase 2

Topoisomerase Inhibitors

Phase 2

Antimetabolites, Antineoplastic

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Dexamethasone & Bupivacaine vs Bupivacaine Alone in Combined Femoral and Sciatic Nerve Block for Perioperative Analgesia in Patients Undergoing Lower Limb Surgeries	Completed	NCT02576782	Phase 4	Perineural Dexamethasone and bupivacaine;Systemic Dexamethasone plus perineural bupivacaine;intravenous saline plus perineural bupivacaine
2	Use of Thalidomide in Patients With Arachnoiditis	Completed	NCT00284505	Phase 2	thalidomide
3	New Combination of Chemoimmunotherapy for Systemic B-cell Lymphoma With Central Nervous System Involvement	Active, not recruiting	NCT02329080	Phase 2	Methotrexate;Rituximab;Cytarabine;Thiotepa;liposomial cytarabine;Etoposide;Ifosfamide;Carmustine
4	Study and Surgical Treatment of Syringomyelia	Completed	NCT00011245
5	Spinal Cord Stimulation (SCS) Therapy Study	Withdrawn	NCT02371122	Not Applicable

Search NIH Clinical Center for Arachnoiditis

Cochrane evidence based reviews: arachnoiditis

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Genetic Tests for Arachnoiditis

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Anatomical Context for Arachnoiditis

MalaCards organs/tissues related to Arachnoiditis:

⁴²

Spinal Cord, Brain, Bone, B Cells, Skin, Testes, Pituitary

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Publications for Arachnoiditis

Articles related to Arachnoiditis:

(show top 50) (show all 481)

#	Title	Authors	Year
1	Can an inflammatory reaction in the meninges, caused by spinal puncture through tattooed skin, evolve into adhesive arachnoiditis? An experimental model in rabbits. ( 30635505 )	da Silva RA...Ganem EM	2019
2	A rare cause of progressive neuropathy: Arachnoiditis ossificans. ( 30706872 )	Kumari M...Choudhary A	2019
3	Adhesive arachnoiditis following lumbar epidural steroid injections: a report of two cases and review of the literature. ( 30774420 )	Eisenberg E...Grinfeld A	2019
4	Arachnoiditis Ossificans: a Rare Etiology of Oil-Based Spinal Myelography and Review of Literature. ( 30862590 )	Wang S...Das S	2019
5	Case Report: Neurobrucellosis with Plastered Spinal Arachnoiditis: A Magnetic Resonance Imaging-Based Report. ( 29345223 )	Nashi S....Nalini A.	2018
6	Cervicothoracic arachnoiditis-a rare complication of aneurysmal intracranial subarachnoid haemorrhage. ( 29977608 )	Swarna S.S....Belci M.	2018
7	Spinal adhesive arachnoiditis following the rupture of an Adamkiewicz aneurysm: Literature review and a case illustration. ( 29433818 )	Todeschi J....Cebula H.	2018
8	Novel Association Between Intrathecal Drug Administration and Arachnoiditis Ossificans. ( 29747017 )	Ward M....Heary R.F.	2018
9	Rare case of diffuse spinal arachnoiditis following a complicated vertebral artery dissection. ( 29605278 )	Atallah E....Jabbour P.	2018
10	Extensive spinal adhesive arachnoiditis after extradural spinal infection - spinal dura mater is no barrier to inflammation. ( 29883820 )	KrAotzig T....Eicker S.O.	2018
11	Delayed Spinal Arachnoiditis Following Aneurysmal Subarachnoid Hemorrhage: A Case Report. ( 29535904 )	Dossani R.H....Cuellar H.	2018
12	Toxic Myelitis and Arachnoiditis After Intrathecal Delivery of Bupivacaine via an Implanted Drug Delivery System: Case Report and Review of the Literature. ( 29719742 )	Huang M....Simpson R.K.	2018
13	Adhesive arachnoiditis following inadvertent epidural injection of 2% chlorhexidine in 70% alcohol-partial recovery over the ensuing eight years. ( 30447665 )	Mohamed Iqbal I...Hersch M	2018
14	Spinal arachnoiditis ossificans: report of a quadruple triggered case. ( 30521955 )	Scalia G...Barbagallo GM	2018
15	Neural Mobilization in a 54-Year-Old Woman With Postoperative Spinal Adhesive Arachnoiditis. ( 30846922 )	Cornelson SM...Kettner NW	2018
16	Late-Onset Non-HLH Presentations of Growth Arrest, Inflammatory Arachnoiditis, and Severe Infectious Mononucleosis, in Siblings with Hypomorphic Defects in UNC13D. ( 28848550 )	Gray P.E....Voskoboinik I.	2017
17	Treatment of syringomyelia in patients with arachnoiditis at the cranio-cervical junction. ( 28842236 )	Davidoff C.L....Stoodley M.A.	2017
18	Letter re: Tuberculous optochiasmatic arachnoiditis and vision loss. ( 28416619 )	Malhotra H.S....Garg R.K.	2017
19	Surgical Management of Syringomyelia Associated with Spinal Adhesive Arachnoiditis, a Late Complication of Tuberculous Meningitis: A Case Report. ( 28512616 )	Lee J.S....Son D.W.	2017
20	Intrathecal hematoma and arachnoiditis mimicking bacterial meningitis after an epidural blood patch. ( 28689621 )	Roy-Gash F....Bonnet M.P.	2017
21	Adhesive arachnoiditis secondary to the use of intrathecal liposoluble contrast. ( 29269177 )	Crespo MartA-nez C....Castro Copete M.C.	2017
22	Author response: Tuberculous optochiasmatic arachnoiditis and vision loss. ( 28416620 )	Dinkin M.J....Chee R.I.	2017
23	Spinal Arachnoiditis as a Complication of Cryptococcal Meningoencephalitis in Non-HIV Previously Healthy Adults. ( 28011613 )	Panackal A.A....Williamson P.R.	2017
24	Tuberculous optochiasmatic arachnoiditis and vision loss. ( 28416621 )		2017
25	Arachnoiditis ossificans associated with syringomyelia: a case report. ( 29092643 )	Wang C....Xuan T.	2017
26	Imaging Appearance of Advanced Chronic Adhesive Arachnoiditis: A Retrospective Review. ( 28639826 )	Anderson T.L....Kotsenas A.L.	2017
27	Patterns of chronic inflammation in extensively treated patients with arachnoiditis and chronic intractable pain. ( 27929717 )	Bilello J.A....Tennant F.S.	2017
28	Intradural Extramedullary Capillary Hemangioma In the Upper Thoracic Spine with Simultaneous Extensive Arachnoiditis. ( 28704911 )	Lee J.H....Kim S.W.	2017
29	Post-traumatic Focal Adhesive Arachnoiditis. ( 30039004 )	Zigic V...Vanhoenacker FM	2017
30	Spinal intradural hydatid cyst causing arachnoiditis: A rare etiology of cauda equina syndrome. ( 27891041 )	Singh S....Behari S.	2016
31	Tuberculous optochiasmatic arachnoiditis and vision loss. ( 27777344 )	Chee R.I....Dinkin M.J.	2016
32	Post-procedure adhesive arachnoiditis following obstetric spinal anaesthesia. ( 27212734 )	Chattopadhyay I....Basu S.	2016
33	Adhesive arachnoiditis in mixed connective tissue disease: a rare neurological manifestation. ( 27986694 )	Khan M.U....Fraser A.	2016
34	A Case of Lumbosacral Arachnoiditis Ossificans. ( 28663987 )	Kasai Y....Sudo A.	2016
35	Acquired Chiari malformation secondary to tuberculous arachnoiditis of the lumbar spine. ( 27625266 )	Kondety S.K....Chatterjee S.	2016
36	Arachnoiditis Ossificans - A Rare Cause of Progressive Myelopathy. ( 26401174 )	Steel C.J....O'Brien W.T.	2015
37	Arachnoiditis ossificans after spinal surgery. ( 25970374 )	Liu L.D....Zhang S.K.	2015
38	Arachnoiditis ossificans and syringomyelia: A unique presentation. ( 26693389 )	Opalak C.F....Opalak M.E.	2015
39	Chronic adhesive arachnoiditis after repeat epidural blood patch. ( 26119259 )	CarlswAord C....Irestedt L.	2015
40	A neuroimaging case of chronic arachnoiditis. ( 25917427 )	Rossi F....Cleto E.	2015
41	Symptomatic spinal cord kinking due to focal adhesive arachnoiditis, with ossification of the ligamentum flavum: a case report. ( 24480938 )	Miyazaki M....Tsumura H.	2014
42	Arachnoiditis ossificans of lumbosacral spine: a case report and literature review. ( 24998238 )	Wang L....Wang Y.P.	2014
43	Familial adhesive arachnoiditis associated with syringomyelia. ( 24481329 )	Pasoglou V....Collignon L.	2014
44	Adhesive arachnoiditis after percutaneous fibrin glue treatment of a sacral meningeal cyst. ( 24702510 )	Hayashi K....Hattori S.	2014
45	Idiopathic opticochiasmatic arachnoiditis. ( 25136775 )	Lessell S....E Grzybowski A.	2014
46	Delayed visual loss from optochiasmatic arachnoiditis after resection of craniopharyngioma. ( 24606404 )	Carreras E.M....Cochrane D.D.	2014
47	Syringomyelia and spinal arachnoiditis resulting from aneurysmal subarachnoid hemorrhage: Report of two cases and review of the literature. ( 25013348 )	Abel T.J....Menezes A.	2014
48	Syringomyelia associated with spinal arachnoiditis treated by partial arachnoid dissection and syrinx-far distal subarachnoid shunt. ( 25232285 )	Iwatsuki K....Ohkawa T.	2014
49	Arachnoiditis ossificans: clinical series and review of the literature. ( 24999276 )	Maulucci C.M....Harrop J.S.	2014
50	Aseptic Arachnoiditis in a Patient Treated With Intrathecal Morphine Infusion: Symptom Resolution on Switch to Ziconotide. ( 24945709 )	Codipietro L....Maino P.	2014

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Genes for Arachnoiditis

Genes related to Arachnoiditis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ACAA1	Acetyl-CoA Acyltransferase 1	Protein Coding	15.01	DISEASES inferred ¹⁵
2	MRI1	Methylthioribose-1-Phosphate Isomerase 1	Protein Coding	14.67	DISEASES inferred ¹⁵
3	POMC	Proopiomelanocortin	Protein Coding	14.64	DISEASES inferred ¹⁵
4	TFG	TRK-Fused Gene	Protein Coding	14.51	DISEASES inferred ¹⁵
5	CRLF1	Cytokine Receptor Like Factor 1	Protein Coding	14.5	DISEASES inferred ¹⁵
6	HSF4	Heat Shock Transcription Factor 4	Protein Coding	14.48	DISEASES inferred ¹⁵

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Variations for Arachnoiditis

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Expression for Arachnoiditis

Search GEO for disease gene expression data for Arachnoiditis.

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Pathways for Arachnoiditis

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GO Terms for Arachnoiditis

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Sources for Arachnoiditis

¹ BioSystems

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¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

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²⁸ GEO DataSets

²⁹ GO

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³¹ HGMD

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³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

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⁴⁹ NCBI Bookshelf

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⁵¹ NCIt

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⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

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⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia