MCID: ARC002
MIFTS: 46

Arachnoiditis

Categories: Genetic diseases, Nephrological diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Arachnoiditis

MalaCards integrated aliases for Arachnoiditis:

Name: Arachnoiditis 12 77 54 45 15 74
Familial Spinal Arachnoiditis 74
Spinal Arachnoiditis 54

Classifications:



Summaries for Arachnoiditis

NIH Rare Diseases : 54 Arachnoiditis is a pain disorder caused by inflammation of the arachnoid, one of the membranes that surrounds and protects the nerves of the spinal cord. The inflammation may occur due to irritation from chemicals; infection; direct injury to the spine; chronic compression of spinal nerves; or complications from spinal surgery or other spinal procedures. It may result in scar tissue and adhesions, which cause the spinal nerves to �??stick�?� together. If arachnoiditis affects the function of nerves, it can cause symptoms such as numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs. In some people. it may affect the bladder, bowel, and sexual function. Very severe arachnoiditis can result in paralysis of the legs. Treatment aims to relieve pain and improve symptoms that impair function. Treatment may include pain medications, physical therapy, and psychotherapy. Surgical treatment is controversial because it offers only short-term relief and may increase formation of scar tissue.

MalaCards based summary : Arachnoiditis, also known as familial spinal arachnoiditis, is related to glossopharyngeal neuralgia and arachnoid cysts. An important gene associated with Arachnoiditis is ACAA1 (Acetyl-CoA Acyltransferase 1). The drugs Bupivacaine and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related phenotypes are muscle weakness and hearing impairment

NINDS : 55 Arachnoiditis is caused by the inflammation of the arachnoid, one of the membranes that surround and protect the nerves of the spinal cord.  The arachnoid can become inflamed because of an irritation from chemicals, infection from bacteria or viruses, as the result of direct injury to the spine, chronic compression of spinal nerves, or complications from spinal surgery or other invasive spinal procedures.  Inflammation can sometimes lead to the formation of scar tissue and adhesions, which cause the spinal nerves to “stick” together. If arachnoiditis begins to interfere with the function of one or more of these nerves, it can cause a number of symptoms, including chronic and persistent pain,  numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs.  Some people with arachnoiditis will have debilitating muscle cramps, twitches, or spasms.  It may also affect bladder, bowel, and sexual function.  In severe cases, arachnoiditis may cause paralysis of the lower limbs.

Wikipedia : 77 Arachnoiditis is an inflammatory condition of the arachnoid mater or ''arachnoid'', one of the membranes... more...

Related Diseases for Arachnoiditis

Diseases related to Arachnoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 310)
# Related Disease Score Top Affiliating Genes
1 glossopharyngeal neuralgia 29.0 CRLF1 POMC
2 arachnoid cysts 12.8
3 spinal intradural arachnoid cysts 12.5
4 tibia absent polydactyly arachnoid cyst 12.5
5 spinal arachnoiditis 12.4
6 arachnoid cysts, intracranial 12.3
7 pachygyria with mental retardation, seizures, and arachnoid cysts 12.3
8 tibia, absence or hypoplasia of, with polydactyly, retrocerebellar arachnoid cyst, and other anomalies 12.1
9 syringomyelia 11.5
10 intracranial cysts 11.5
11 melanosis, neurocutaneous 11.5
12 meningioma, familial 11.5
13 chudley-mccullough syndrome 11.4
14 meningitis 11.4
15 craniopharyngioma 11.3
16 dandy-walker complex 11.3
17 amyloidosis, hereditary, transthyretin-related 11.0
18 polycystic kidney disease 1 with or without polycystic liver disease 11.0
19 syringomyelia, noncommunicating isolated 11.0
20 acrocallosal syndrome 11.0
21 encephalocraniocutaneous lipomatosis 11.0
22 pachygyria-intellectual disability-epilepsy syndrome 11.0
23 tarlov cysts 11.0
24 hydrocephalus 10.5
25 headache 10.3
26 tuberculous meningitis 10.2
27 cauda equina syndrome 10.2
28 intracranial hypertension 10.2
29 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
30 epilepsy 10.2
31 precocious puberty 10.1
32 spondyloarthropathy 1 10.1
33 trigeminal neuralgia 10.1
34 spondylitis 10.1
35 hydrocephalus, normal-pressure 10.1
36 neuropathy 10.1
37 polycystic kidney disease 10.0
38 sensorineural hearing loss 10.0
39 communicating hydrocephalus 10.0
40 kidney disease 10.0
41 chiari malformation 10.0
42 congenital hydrocephalus 10.0
43 glioma 10.0
44 schizophrenia 10.0
45 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.0
46 spinal meningioma 10.0
47 acoustic neuroma 10.0
48 paraplegia 10.0
49 adenoma 10.0
50 autosomal dominant polycystic kidney disease 10.0

Graphical network of the top 20 diseases related to Arachnoiditis:



Diseases related to Arachnoiditis

Symptoms & Phenotypes for Arachnoiditis

Human phenotypes related to Arachnoiditis:

33 (show all 13)
# Description HPO Frequency HPO Source Accession
1 muscle weakness 33 hallmark (90%) HP:0001324
2 hearing impairment 33 hallmark (90%) HP:0000365
3 abnormality of vision 33 hallmark (90%) HP:0000504
4 arthralgia 33 hallmark (90%) HP:0002829
5 paresthesia 33 hallmark (90%) HP:0003401
6 meningitis 33 hallmark (90%) HP:0001287
7 hyporeflexia 33 hallmark (90%) HP:0001265
8 tinnitus 33 hallmark (90%) HP:0000360
9 anhidrosis 33 frequent (33%) HP:0000970
10 hydrocephalus 33 occasional (7.5%) HP:0000238
11 fatigue 33 occasional (7.5%) HP:0012378
12 urinary bladder sphincter dysfunction 33 occasional (7.5%) HP:0002839
13 migraine 33 occasional (7.5%) HP:0002076

GenomeRNAi Phenotypes related to Arachnoiditis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-150 9.56 TFG
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 9.56 ACAA1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.56 ACAA1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.56 TFG
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.56 TFG
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.56 ACAA1 TFG
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.56 ACAA1
8 Increased transferrin (TF) endocytosis GR00363-A 9.02 ACAA1 CRLF1 HSF4 MRI1 POMC

Drugs & Therapeutics for Arachnoiditis

Drugs for Arachnoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4 Central Nervous System Depressants Phase 4
5 Peripheral Nervous System Agents Phase 4
6 Anti-Inflammatory Agents Phase 4
7 HIV Protease Inhibitors Phase 4
8 Hormones Phase 4
9
protease inhibitors Phase 4
10 Autonomic Agents Phase 4
11 BB 1101 Phase 4
12 Anesthetics Phase 4
13 Anesthetics, Local Phase 4
14 Antineoplastic Agents, Hormonal Phase 4
15 Hormone Antagonists Phase 4
16 Antiemetics Phase 4
17 Gastrointestinal Agents Phase 4
18 glucocorticoids Phase 4
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
20
Carmustine Approved, Investigational Phase 2 154-93-8 2578
21
Ifosfamide Approved Phase 2 3778-73-2 3690
22
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
23
Carboplatin Approved Phase 2 41575-94-4 38904 10339178 498142
24
Clonazepam Approved, Illicit Phase 2 1622-61-3 2802
25
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
26
Busulfan Approved, Investigational Phase 2 55-98-1 2478
27
Etoposide Approved Phase 2 33419-42-0 36462
28
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
29
Cytarabine Approved, Experimental, Investigational Phase 2 147-94-4, 65-46-3 6253
30
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
31
rituximab Approved Phase 2 174722-31-7 10201696
32
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
33
leucovorin Approved Phase 2 58-05-9 6006 143
34
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
35 Immunologic Factors Phase 2
36 Immunosuppressive Agents Phase 2
37 Anti-Infective Agents Phase 2
38 Anti-Bacterial Agents Phase 2
39 Angiogenesis Modulating Agents Phase 2
40 Angiogenesis Inhibitors Phase 2
41 Hydrocortisone 17-butyrate 21-propionate Phase 2
42
Isophosphamide mustard Phase 2 0
43 Antineoplastic Agents, Alkylating Phase 2
44 Antiviral Agents Phase 2
45 Vitamin B Complex Phase 2
46 Antimetabolites Phase 2
47 Antineoplastic Agents, Immunological Phase 2
48 Etoposide phosphate Phase 2
49 Topoisomerase Inhibitors Phase 2
50 Antimetabolites, Antineoplastic Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dexamethasone & Bupivacaine vs Bupivacaine Alone in Combined Femoral and Sciatic Nerve Block for Perioperative Analgesia in Patients Undergoing Lower Limb Surgeries Completed NCT02576782 Phase 4 Perineural Dexamethasone and bupivacaine;Systemic Dexamethasone plus perineural bupivacaine;intravenous saline plus perineural bupivacaine
2 Use of Thalidomide in Patients With Arachnoiditis Completed NCT00284505 Phase 2 thalidomide
3 New Combination of Chemoimmunotherapy for Systemic B-cell Lymphoma With Central Nervous System Involvement Active, not recruiting NCT02329080 Phase 2 Methotrexate;Rituximab;Cytarabine;Thiotepa;liposomial cytarabine;Etoposide;Ifosfamide;Carmustine
4 Study and Surgical Treatment of Syringomyelia Completed NCT00011245
5 Spinal Cord Stimulation (SCS) Therapy Study Withdrawn NCT02371122 Not Applicable

Search NIH Clinical Center for Arachnoiditis

Cochrane evidence based reviews: arachnoiditis

Genetic Tests for Arachnoiditis

Anatomical Context for Arachnoiditis

MalaCards organs/tissues related to Arachnoiditis:

42
Spinal Cord, Brain, Bone, B Cells, Skin, Testes, Pituitary

Publications for Arachnoiditis

Articles related to Arachnoiditis:

(show top 50) (show all 481)
# Title Authors Year
1
Can an inflammatory reaction in the meninges, caused by spinal puncture through tattooed skin, evolve into adhesive arachnoiditis? An experimental model in rabbits. ( 30635505 )
2019
2
A rare cause of progressive neuropathy: Arachnoiditis ossificans. ( 30706872 )
2019
3
Adhesive arachnoiditis following lumbar epidural steroid injections: a report of two cases and review of the literature. ( 30774420 )
2019
4
Arachnoiditis Ossificans: a Rare Etiology of Oil-Based Spinal Myelography and Review of Literature. ( 30862590 )
2019
5
Case Report: Neurobrucellosis with Plastered Spinal Arachnoiditis: A Magnetic Resonance Imaging-Based Report. ( 29345223 )
2018
6
Cervicothoracic arachnoiditis-a rare complication of aneurysmal intracranial subarachnoid haemorrhage. ( 29977608 )
2018
7
Spinal adhesive arachnoiditis following the rupture of an Adamkiewicz aneurysm: Literature review and a case illustration. ( 29433818 )
2018
8
Novel Association Between Intrathecal Drug Administration and Arachnoiditis Ossificans. ( 29747017 )
2018
9
Rare case of diffuse spinal arachnoiditis following a complicated vertebral artery dissection. ( 29605278 )
2018
10
Extensive spinal adhesive arachnoiditis after extradural spinal infection - spinal dura mater is no barrier to inflammation. ( 29883820 )
2018
11
Delayed Spinal Arachnoiditis Following Aneurysmal Subarachnoid Hemorrhage: A Case Report. ( 29535904 )
2018
12
Toxic Myelitis and Arachnoiditis After Intrathecal Delivery of Bupivacaine via an Implanted Drug Delivery System: Case Report and Review of the Literature. ( 29719742 )
2018
13
Adhesive arachnoiditis following inadvertent epidural injection of 2% chlorhexidine in 70% alcohol-partial recovery over the ensuing eight years. ( 30447665 )
2018
14
Spinal arachnoiditis ossificans: report of a quadruple triggered case. ( 30521955 )
2018
15
Neural Mobilization in a 54-Year-Old Woman With Postoperative Spinal Adhesive Arachnoiditis. ( 30846922 )
2018
16
Late-Onset Non-HLH Presentations of Growth Arrest, Inflammatory Arachnoiditis, and Severe Infectious Mononucleosis, in Siblings with Hypomorphic Defects in UNC13D. ( 28848550 )
2017
17
Treatment of syringomyelia in patients with arachnoiditis at the cranio-cervical junction. ( 28842236 )
2017
18
Letter re: Tuberculous optochiasmatic arachnoiditis and vision loss. ( 28416619 )
2017
19
Surgical Management of Syringomyelia Associated with Spinal Adhesive Arachnoiditis, a Late Complication of Tuberculous Meningitis: A Case Report. ( 28512616 )
2017
20
Intrathecal hematoma and arachnoiditis mimicking bacterial meningitis after an epidural blood patch. ( 28689621 )
2017
21
Adhesive arachnoiditis secondary to the use of intrathecal liposoluble contrast. ( 29269177 )
2017
22
Author response: Tuberculous optochiasmatic arachnoiditis and vision loss. ( 28416620 )
2017
23
Spinal Arachnoiditis as a Complication of Cryptococcal Meningoencephalitis in Non-HIV Previously Healthy Adults. ( 28011613 )
2017
24
Tuberculous optochiasmatic arachnoiditis and vision loss. ( 28416621 )
2017
25
Arachnoiditis ossificans associated with syringomyelia: a case report. ( 29092643 )
2017
26
Imaging Appearance of Advanced Chronic Adhesive Arachnoiditis: A Retrospective Review. ( 28639826 )
2017
27
Patterns of chronic inflammation in extensively treated patients with arachnoiditis and chronic intractable pain. ( 27929717 )
2017
28
Intradural Extramedullary Capillary Hemangioma In the Upper Thoracic Spine with Simultaneous Extensive Arachnoiditis. ( 28704911 )
2017
29
Post-traumatic Focal Adhesive Arachnoiditis. ( 30039004 )
2017
30
Spinal intradural hydatid cyst causing arachnoiditis: A rare etiology of cauda equina syndrome. ( 27891041 )
2016
31
Tuberculous optochiasmatic arachnoiditis and vision loss. ( 27777344 )
2016
32
Post-procedure adhesive arachnoiditis following obstetric spinal anaesthesia. ( 27212734 )
2016
33
Adhesive arachnoiditis in mixed connective tissue disease: a rare neurological manifestation. ( 27986694 )
2016
34
A Case of Lumbosacral Arachnoiditis Ossificans. ( 28663987 )
2016
35
Acquired Chiari malformation secondary to tuberculous arachnoiditis of the lumbar spine. ( 27625266 )
2016
36
Arachnoiditis Ossificans - A Rare Cause of Progressive Myelopathy. ( 26401174 )
2015
37
Arachnoiditis ossificans after spinal surgery. ( 25970374 )
2015
38
Arachnoiditis ossificans and syringomyelia: A unique presentation. ( 26693389 )
2015
39
Chronic adhesive arachnoiditis after repeat epidural blood patch. ( 26119259 )
2015
40
A neuroimaging case of chronic arachnoiditis. ( 25917427 )
2015
41
Symptomatic spinal cord kinking due to focal adhesive arachnoiditis, with ossification of the ligamentum flavum: a case report. ( 24480938 )
2014
42
Arachnoiditis ossificans of lumbosacral spine: a case report and literature review. ( 24998238 )
2014
43
Familial adhesive arachnoiditis associated with syringomyelia. ( 24481329 )
2014
44
Adhesive arachnoiditis after percutaneous fibrin glue treatment of a sacral meningeal cyst. ( 24702510 )
2014
45
Idiopathic opticochiasmatic arachnoiditis. ( 25136775 )
2014
46
Delayed visual loss from optochiasmatic arachnoiditis after resection of craniopharyngioma. ( 24606404 )
2014
47
Syringomyelia and spinal arachnoiditis resulting from aneurysmal subarachnoid hemorrhage: Report of two cases and review of the literature. ( 25013348 )
2014
48
Syringomyelia associated with spinal arachnoiditis treated by partial arachnoid dissection and syrinx-far distal subarachnoid shunt. ( 25232285 )
2014
49
Arachnoiditis ossificans: clinical series and review of the literature. ( 24999276 )
2014
50
Aseptic Arachnoiditis in a Patient Treated With Intrathecal Morphine Infusion: Symptom Resolution on Switch to Ziconotide. ( 24945709 )
2014

Variations for Arachnoiditis

Expression for Arachnoiditis

Search GEO for disease gene expression data for Arachnoiditis.

Pathways for Arachnoiditis

GO Terms for Arachnoiditis

Sources for Arachnoiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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