MCID: ARC002
MIFTS: 44

Arachnoiditis

Categories: Genetic diseases, Nephrological diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Arachnoiditis

MalaCards integrated aliases for Arachnoiditis:

Name: Arachnoiditis 12 76 53 44 15 73
Familial Spinal Arachnoiditis 73
Spinal Arachnoiditis 53

Classifications:



Summaries for Arachnoiditis

NIH Rare Diseases : 53 Arachnoiditis is a pain disorder caused by inflammation of the arachnoid, one of the membranes that surrounds and protects the nerves of the spinal cord. The inflammation may occur due to irritation from chemicals; infection; direct injury to the spine; chronic compression of spinal nerves; or complications from spinal surgery or other spinal procedures. It may result in scar tissue and adhesions, which cause the spinal nerves to �??stick�?� together. If arachnoiditis affects the function of nerves, it can cause symptoms such as numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs. In some people. it may affect the bladder, bowel, and sexual function. Very severe arachnoiditis can result in paralysis of the legs. Treatment aims to relieve pain and improve symptoms that impair function. Treatment may include pain medications, physical therapy, and psychotherapy. Surgical treatment is controversial because it offers only short-term relief and may increase formation of scar tissue.

MalaCards based summary : Arachnoiditis, also known as familial spinal arachnoiditis, is related to epidural abscess and arachnoid cysts. An important gene associated with Arachnoiditis is TSHZ1 (Teashirt Zinc Finger Homeobox 1). The drugs Dexamethasone acetate and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related phenotypes are hydrocephalus and muscle weakness

NINDS : 54 Arachnoiditis is caused by the inflammation of the arachnoid, one of the membranes that surround and protect the nerves of the spinal cord.  The arachnoid can become inflamed because of an irritation from chemicals, infection from bacteria or viruses, as the result of direct injury to the spine, chronic compression of spinal nerves, or complications from spinal surgery or other invasive spinal procedures.  Inflammation can sometimes lead to the formation of scar tissue and adhesions, which cause the spinal nerves to “stick” together. If arachnoiditis begins to interfere with the function of one or more of these nerves, it can cause a number of symptoms, including chronic and persistent pain,  numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs.  Some people with arachnoiditis will have debilitating muscle cramps, twitches, or spasms.  It may also affect bladder, bowel, and sexual function.  In severe cases, arachnoiditis may cause paralysis of the lower limbs.

Wikipedia : 76 Arachnoiditis is an inflammatory condition of the arachnoid mater or ''arachnoid'', one of the membranes... more...

Related Diseases for Arachnoiditis

Diseases related to Arachnoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 293)
# Related Disease Score Top Affiliating Genes
1 epidural abscess 29.0 MNX1 MRI1
2 arachnoid cysts 12.7
3 spinal intradural arachnoid cysts 12.5
4 tibia absent polydactyly arachnoid cyst 12.5
5 spinal arachnoiditis 12.4
6 arachnoid cysts, intracranial 12.3
7 pachygyria with mental retardation, seizures, and arachnoid cysts 12.2
8 tibia, absence or hypoplasia of, with polydactyly, retrocerebellar arachnoid cyst, and other anomalies 12.1
9 syringomyelia 11.5
10 intracranial cysts 11.5
11 melanosis, neurocutaneous 11.4
12 meningioma, familial 11.4
13 chudley-mccullough syndrome 11.4
14 retrocerebellar cyst 11.4
15 meningitis 11.4
16 craniopharyngioma 11.3
17 dandy-walker complex 11.3
18 amyloidosis, hereditary, transthyretin-related 11.0
19 polycystic kidney disease 1 with or without polycystic liver disease 11.0
20 syringomyelia, noncommunicating isolated 11.0
21 acrocallosal syndrome 11.0
22 encephalocraniocutaneous lipomatosis 11.0
23 pachygyria-intellectual disability-epilepsy syndrome 11.0
24 tarlov cysts 11.0
25 hydrocephalus 10.5
26 headache 10.3
27 tuberculous meningitis 10.2
28 cauda equina syndrome 10.2
29 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
30 epilepsy 10.1
31 trigeminal neuralgia 10.1
32 intracranial hypertension 10.1
33 precocious puberty 10.1
34 spondyloarthropathy 1 10.1
35 hydrocephalus, normal-pressure 10.1
36 spondylitis 10.1
37 polycystic kidney disease 10.0
38 sensorineural hearing loss 10.0
39 communicating hydrocephalus 10.0
40 kidney disease 10.0
41 glioma 10.0
42 schizophrenia 10.0
43 paraplegia 10.0
44 neuropathy 10.0
45 autosomal dominant polycystic kidney disease 10.0
46 chiari malformation 10.0
47 head injury 10.0
48 facial paralysis 10.0
49 obstructive hydrocephalus 10.0
50 cranial nerve palsy 10.0

Graphical network of the top 20 diseases related to Arachnoiditis:



Diseases related to Arachnoiditis

Symptoms & Phenotypes for Arachnoiditis

Human phenotypes related to Arachnoiditis:

32 (show all 13)
# Description HPO Frequency HPO Source Accession
1 hydrocephalus 32 occasional (7.5%) HP:0000238
2 muscle weakness 32 hallmark (90%) HP:0001324
3 hearing impairment 32 hallmark (90%) HP:0000365
4 fatigue 32 occasional (7.5%) HP:0012378
5 abnormality of vision 32 hallmark (90%) HP:0000504
6 arthralgia 32 hallmark (90%) HP:0002829
7 urinary bladder sphincter dysfunction 32 occasional (7.5%) HP:0002839
8 migraine 32 occasional (7.5%) HP:0002076
9 paresthesia 32 hallmark (90%) HP:0003401
10 meningitis 32 hallmark (90%) HP:0001287
11 hyporeflexia 32 hallmark (90%) HP:0001265
12 tinnitus 32 hallmark (90%) HP:0000360
13 anhidrosis 32 frequent (33%) HP:0000970

Drugs & Therapeutics for Arachnoiditis

Drugs for Arachnoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
2
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4 Central Nervous System Depressants Phase 4
5 Antineoplastic Agents, Hormonal Phase 4
6 Hormone Antagonists Phase 4
7 Peripheral Nervous System Agents Phase 4
8 Anesthetics Phase 4
9 Anesthetics, Local Phase 4
10 Autonomic Agents Phase 4
11 Hormones Phase 4
12 HIV Protease Inhibitors Phase 4
13 Antiemetics Phase 4
14 Anti-Inflammatory Agents Phase 4
15 Gastrointestinal Agents Phase 4
16 BB 1101 Phase 4
17 glucocorticoids Phase 4
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
19
protease inhibitors Phase 4
20
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
21
leucovorin Approved Phase 2 58-05-9 6006 143
22
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
23
rituximab Approved Phase 2 174722-31-7 10201696
24
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
25
Methotrexate Approved Phase 2 59-05-2, 1959-05-2 126941
26
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
27
Busulfan Approved, Investigational Phase 2 55-98-1 2478
28
Ifosfamide Approved Phase 2 3778-73-2 3690
29
Clonazepam Approved, Illicit Phase 2 1622-61-3 2802
30
Etoposide Approved Phase 2 33419-42-0 36462
31
Carmustine Approved, Investigational Phase 2 154-93-8 2578
32
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
33
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
34
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
35 Anti-Bacterial Agents Phase 2
36 Angiogenesis Inhibitors Phase 2
37 Immunologic Factors Phase 2
38 Angiogenesis Modulating Agents Phase 2
39 Anti-Infective Agents Phase 2
40 Immunosuppressive Agents Phase 2
41 Folate Phase 2
42 Hydrocortisone 17-butyrate 21-propionate Phase 2
43
Isophosphamide mustard Phase 2 0
44 Topoisomerase Inhibitors Phase 2
45 Vitamin B9 Phase 2
46 Antirheumatic Agents Phase 2
47 Vitamin B Complex Phase 2
48 Antineoplastic Agents, Alkylating Phase 2
49 Antiviral Agents Phase 2
50 Folic Acid Antagonists Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dexamethasone & Bupivacaine vs Bupivacaine Alone in Combined Femoral and Sciatic Nerve Block for Perioperative Analgesia in Patients Undergoing Lower Limb Surgeries Completed NCT02576782 Phase 4 Perineural Dexamethasone and bupivacaine;Systemic Dexamethasone plus perineural bupivacaine;intravenous saline plus perineural bupivacaine
2 Use of Thalidomide in Patients With Arachnoiditis Completed NCT00284505 Phase 2 thalidomide
3 New Combination of Chemoimmunotherapy for Systemic B-cell Lymphoma With Central Nervous System Involvement Recruiting NCT02329080 Phase 2 Methotrexate;Rituximab;Cytarabine;Thiotepa;liposomial cytarabine;Etoposide;Ifosfamide;Carmustine
4 Study and Surgical Treatment of Syringomyelia Completed NCT00011245
5 Spinal Cord Stimulation (SCS) Therapy Study Withdrawn NCT02371122 Not Applicable

Search NIH Clinical Center for Arachnoiditis

Cochrane evidence based reviews: arachnoiditis

Genetic Tests for Arachnoiditis

Anatomical Context for Arachnoiditis

MalaCards organs/tissues related to Arachnoiditis:

41
Spinal Cord, Brain, Bone, Pituitary, Kidney, B Cells, Myeloid

Publications for Arachnoiditis

Articles related to Arachnoiditis:

(show top 50) (show all 476)
# Title Authors Year
1
Case Report: Neurobrucellosis with Plastered Spinal Arachnoiditis: A Magnetic Resonance Imaging-Based Report. ( 29345223 )
2018
2
Cervicothoracic arachnoiditis-a rare complication of aneurysmal intracranial subarachnoid haemorrhage. ( 29977608 )
2018
3
Spinal adhesive arachnoiditis following the rupture of an Adamkiewicz aneurysm: Literature review and a case illustration. ( 29433818 )
2018
4
Novel Association Between Intrathecal Drug Administration and Arachnoiditis Ossificans. ( 29747017 )
2018
5
Rare case of diffuse spinal arachnoiditis following a complicated vertebral artery dissection. ( 29605278 )
2018
6
Extensive spinal adhesive arachnoiditis after extradural spinal infection - spinal dura mater is no barrier to inflammation. ( 29883820 )
2018
7
Delayed Spinal Arachnoiditis Following Aneurysmal Subarachnoid Hemorrhage: A Case Report. ( 29535904 )
2018
8
Toxic Myelitis and Arachnoiditis After Intrathecal Delivery of Bupivacaine via an Implanted Drug Delivery System: Case Report and Review of the Literature. ( 29719742 )
2018
9
Adhesive arachnoiditis following inadvertent epidural injection of 2% chlorhexidine in 70% alcohol-partial recovery over the ensuing eight years. ( 30447665 )
2018
10
Spinal arachnoiditis ossificans: report of a quadruple triggered case. ( 30521955 )
2018
11
Late-Onset Non-HLH Presentations of Growth Arrest, Inflammatory Arachnoiditis, and Severe Infectious Mononucleosis, in Siblings with Hypomorphic Defects in UNC13D. ( 28848550 )
2017
12
Treatment of syringomyelia in patients with arachnoiditis at the cranio-cervical junction. ( 28842236 )
2017
13
Letter re: Tuberculous optochiasmatic arachnoiditis and vision loss. ( 28416619 )
2017
14
Surgical Management of Syringomyelia Associated with Spinal Adhesive Arachnoiditis, a Late Complication of Tuberculous Meningitis: A Case Report. ( 28512616 )
2017
15
Intrathecal hematoma and arachnoiditis mimicking bacterial meningitis after an epidural blood patch. ( 28689621 )
2017
16
Adhesive arachnoiditis secondary to the use of intrathecal liposoluble contrast. ( 29269177 )
2017
17
Author response: Tuberculous optochiasmatic arachnoiditis and vision loss. ( 28416620 )
2017
18
Spinal Arachnoiditis as a Complication of Cryptococcal Meningoencephalitis in Non-HIV Previously Healthy Adults. ( 28011613 )
2017
19
Tuberculous optochiasmatic arachnoiditis and vision loss. ( 28416621 )
2017
20
Arachnoiditis ossificans associated with syringomyelia: a case report. ( 29092643 )
2017
21
Imaging Appearance of Advanced Chronic Adhesive Arachnoiditis: A Retrospective Review. ( 28639826 )
2017
22
Patterns of chronic inflammation in extensively treated patients with arachnoiditis and chronic intractable pain. ( 27929717 )
2017
23
Intradural Extramedullary Capillary Hemangioma In the Upper Thoracic Spine with Simultaneous Extensive Arachnoiditis. ( 28704911 )
2017
24
Post-traumatic Focal Adhesive Arachnoiditis. ( 30039004 )
2017
25
Spinal intradural hydatid cyst causing arachnoiditis: A rare etiology of cauda equina syndrome. ( 27891041 )
2016
26
Tuberculous optochiasmatic arachnoiditis and vision loss. ( 27777344 )
2016
27
Post-procedure adhesive arachnoiditis following obstetric spinal anaesthesia. ( 27212734 )
2016
28
Adhesive arachnoiditis in mixed connective tissue disease: a rare neurological manifestation. ( 27986694 )
2016
29
A Case of Lumbosacral Arachnoiditis Ossificans. ( 28663987 )
2016
30
Acquired Chiari malformation secondary to tuberculous arachnoiditis of the lumbar spine. ( 27625266 )
2016
31
Arachnoiditis Ossificans - A Rare Cause of Progressive Myelopathy. ( 26401174 )
2015
32
Arachnoiditis ossificans after spinal surgery. ( 25970374 )
2015
33
Arachnoiditis ossificans and syringomyelia: A unique presentation. ( 26693389 )
2015
34
Chronic adhesive arachnoiditis after repeat epidural blood patch. ( 26119259 )
2015
35
A neuroimaging case of chronic arachnoiditis. ( 25917427 )
2015
36
Symptomatic spinal cord kinking due to focal adhesive arachnoiditis, with ossification of the ligamentum flavum: a case report. ( 24480938 )
2014
37
Arachnoiditis ossificans of lumbosacral spine: a case report and literature review. ( 24998238 )
2014
38
Familial adhesive arachnoiditis associated with syringomyelia. ( 24481329 )
2014
39
Adhesive arachnoiditis after percutaneous fibrin glue treatment of a sacral meningeal cyst. ( 24702510 )
2014
40
Idiopathic opticochiasmatic arachnoiditis. ( 25136775 )
2014
41
Delayed visual loss from optochiasmatic arachnoiditis after resection of craniopharyngioma. ( 24606404 )
2014
42
Syringomyelia and spinal arachnoiditis resulting from aneurysmal subarachnoid hemorrhage: Report of two cases and review of the literature. ( 25013348 )
2014
43
Syringomyelia associated with spinal arachnoiditis treated by partial arachnoid dissection and syrinx-far distal subarachnoid shunt. ( 25232285 )
2014
44
Arachnoiditis ossificans: clinical series and review of the literature. ( 24999276 )
2014
45
Aseptic Arachnoiditis in a Patient Treated With Intrathecal Morphine Infusion: Symptom Resolution on Switch to Ziconotide. ( 24945709 )
2014
46
Subarachnoid-subarachnoid bypass for spinal adhesive arachnoiditis. ( 25170651 )
2014
47
Tuberculous optochiasmatic arachnoiditis. ( 24926172 )
2014
48
Compressive Cervicothoracic Adhesive Arachnoiditis following Aneurysmal Subarachnoid Hemorrhage: A Case Report and Literature Review. ( 25083391 )
2014
49
Spinal arachnoid cyst associated with arachnoiditis following subarachnoid haemorrhage in adult patients: A case report and literature review. ( 25365662 )
2014
50
History of myelography with pantopaque contributing to arachnoiditis. ( 25289151 )
2014

Variations for Arachnoiditis

Expression for Arachnoiditis

Search GEO for disease gene expression data for Arachnoiditis.

Pathways for Arachnoiditis

GO Terms for Arachnoiditis

Sources for Arachnoiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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