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MCID: ARC002
MIFTS: 45

Arachnoiditis

Categories: Rare diseases, Neuronal diseases, Genetic diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Arachnoiditis

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MalaCards integrated aliases for Arachnoiditis:

Name: Arachnoiditis 12 76 53 54 44 15 73
Familial Spinal Arachnoiditis 73
Spinal Arachnoiditis 53

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33


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Summaries for Arachnoiditis

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NIH Rare Diseases : 53 Arachnoiditis is a pain disorder caused by inflammation of the arachnoid, one of the membranes that surrounds and protects the nerves of the spinal cord. The inflammation may occur due to irritation from chemicals; infection; direct injury to the spine; chronic compression of spinal nerves; or complications from spinal surgery or other spinal procedures. It may result in scar tissue and adhesions, which cause the spinal nerves to “stick” together. If arachnoiditis affects the function of nerves, it can cause symptoms such as numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs. In some people. it may affect the bladder, bowel, and sexual function. Very severe arachnoiditis can result in paralysis of the legs. Treatment aims to relieve pain and improve symptoms that impair function. Treatment may include pain medications, physical therapy, and psychotherapy. Surgical treatment is controversial because it offers only short-term relief and may increase formation of scar tissue.

MalaCards based summary : Arachnoiditis, also known as familial spinal arachnoiditis, is related to epidural abscess and arachnoid cysts. An important gene associated with Arachnoiditis is ACAA1 (Acetyl-CoA Acyltransferase 1). The drugs Bupivacaine and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related phenotypes are hydrocephalus and tinnitus

NINDS : 54 Arachnoiditis is caused by the inflammation of the arachnoid, one of the membranes that surround and protect the nerves of the spinal cord.  The arachnoid can become inflamed because of an irritation from chemicals, infection from bacteria or viruses, as the result of direct injury to the spine, chronic compression of spinal nerves, or complications from spinal surgery or other invasive spinal procedures.  Inflammation can sometimes lead to the formation of scar tissue and adhesions, which cause the spinal nerves to “stick” together. If arachnoiditis begins to interfere with the function of one or more of these nerves, it can cause a number of symptoms, including chronic and persistent pain,  numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs.  Some people with arachnoiditis will have debilitating muscle cramps, twitches, or spasms.  It may also affect bladder, bowel, and sexual function.  In severe cases, arachnoiditis may cause paralysis of the lower limbs.

Wikipedia : 76 Arachnoiditis is an inflammatory condition of the arachnoid mater or \'arachnoid\', one of the membranes... more...

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Related Diseases for Arachnoiditis

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Diseases related to Arachnoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 250)
# Related Disease Score Top Affiliating Genes
1 epidural abscess 28.1 MNX1 MRI1
2 arachnoid cysts 12.6
3 spinal intradural arachnoid cysts 12.4
4 tibia absent polydactyly arachnoid cyst 12.3
5 spinal arachnoiditis 12.2
6 arachnoid cysts, intracranial 12.1
7 pachygyria with mental retardation, seizures, and arachnoid cysts 12.1
8 tibia, absence or hypoplasia of, with polydactyly, retrocerebellar arachnoid cyst, and other anomalies 11.9
9 syringomyelia 11.4
10 intracranial cysts 11.4
11 melanosis, neurocutaneous 11.3
12 chudley-mccullough syndrome 11.2
13 meningitis 11.2
14 craniopharyngioma 11.2
15 dandy-walker complex 11.1
16 meningioma, familial 11.1
17 retrocerebellar cyst 10.9
18 amyloidosis, hereditary, transthyretin-related 10.8
19 polycystic kidney disease 1 with or without polycystic liver disease 10.8
20 syringomyelia, noncommunicating isolated 10.8
21 acrocallosal syndrome 10.8
22 encephalocraniocutaneous lipomatosis 10.8
23 hydrocephalus 10.3
24 aneurysm 10.1
25 tuberculous meningitis 10.1
26 cauda equina syndrome 10.1
27 cervicitis 10.1
28 cerebritis 10.0
29 headache 10.0
30 spondyloarthropathy 1 9.9
31 spondylitis 9.9
32 type i 9.9
33 communicating hydrocephalus 9.9
34 epilepsy 9.9
35 trigeminal neuralgia 9.9
36 obstructive hydrocephalus 9.8
37 paraplegia 9.8
38 intracranial hypertension 9.8
39 bobble-head doll syndrome 9.8
40 glioma 9.8
41 hydrocephalus, normal-pressure 9.8
42 meningocele 9.8
43 choroiditis 9.8
44 cranial nerve palsy 9.8
45 optic nerve glioma 9.8
46 syringohydromyelia 9.8
47 distichiasis 9.7
48 aging 9.7
49 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.7
50 lymphedema 9.7

Graphical network of the top 20 diseases related to Arachnoiditis:



Diseases related to Arachnoiditis
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Symptoms & Phenotypes for Arachnoiditis

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Human phenotypes related to Arachnoiditis:

32 (show all 13)
# Description HPO Frequency HPO Source Accession
1 hydrocephalus 32 occasional (7.5%) HP:0000238
2 tinnitus 32 hallmark (90%) HP:0000360
3 hearing impairment 32 hallmark (90%) HP:0000365
4 abnormality of vision 32 hallmark (90%) HP:0000504
5 anhidrosis 32 frequent (33%) HP:0000970
6 hyporeflexia 32 hallmark (90%) HP:0001265
7 meningitis 32 hallmark (90%) HP:0001287
8 muscle weakness 32 hallmark (90%) HP:0001324
9 migraine 32 occasional (7.5%) HP:0002076
10 arthralgia 32 hallmark (90%) HP:0002829
11 urinary bladder sphincter dysfunction 32 occasional (7.5%) HP:0002839
12 paresthesia 32 hallmark (90%) HP:0003401
13 fatigue 32 occasional (7.5%) HP:0012378
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Drugs & Therapeutics for Arachnoiditis

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Drugs for Arachnoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3 Anesthetics Phase 4
4 Anesthetics, Local Phase 4
5 Antiemetics Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 Autonomic Agents Phase 4
9 BB 1101 Phase 4
10 Central Nervous System Depressants Phase 4
11 Dexamethasone acetate Phase 4 1177-87-3
12 Gastrointestinal Agents Phase 4
13 glucocorticoids Phase 4
14 HIV Protease Inhibitors Phase 4
15 Hormone Antagonists Phase 4
16 Hormones Phase 4
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
18 Peripheral Nervous System Agents Phase 4
19
protease inhibitors Phase 4
20
Busulfan Approved, Investigational Phase 2 55-98-1 2478
21
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
22
Carmustine Approved, Investigational Phase 2 154-93-8 2578
23
Clonazepam Approved, Illicit Phase 2 1622-61-3 2802
24
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
25
Etoposide Approved Phase 2 33419-42-0 36462
26
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
27
Ifosfamide Approved Phase 2 3778-73-2 3690
28
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
29
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
30
rituximab Approved Phase 2 174722-31-7 10201696
31
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
32
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
33
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
34 Angiogenesis Inhibitors Phase 2
35 Angiogenesis Modulating Agents Phase 2
36 Anti-Bacterial Agents Phase 2
37 Anti-Infective Agents Phase 2
38 Immunosuppressive Agents Phase 2
39 Alkylating Agents Phase 2
40 Antimetabolites Phase 2
41 Antimetabolites, Antineoplastic Phase 2
42 Antineoplastic Agents, Alkylating Phase 2
43 Antineoplastic Agents, Phytogenic Phase 2
44 Antirheumatic Agents Phase 2
45 Antiviral Agents Phase 2
46 Cortisol succinate Phase 2
47 Dermatologic Agents Phase 2
48 Etoposide phosphate Phase 2
49 Folic Acid Antagonists Phase 2
50 Hydrocortisone 17-butyrate 21-propionate Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dexamethasone & Bupivacaine vs Bupivacaine Alone in Combined Femoral and Sciatic Nerve Block for Perioperative Analgesia in Patients Undergoing Lower Limb Surgeries Completed NCT02576782 Phase 4 Perineural Dexamethasone and bupivacaine;Systemic Dexamethasone plus perineural bupivacaine;intravenous saline plus perineural bupivacaine
2 Use of Thalidomide in Patients With Arachnoiditis Completed NCT00284505 Phase 2 thalidomide
3 New Combination of Chemoimmunotherapy for Systemic B-cell Lymphoma With Central Nervous System Involvement Recruiting NCT02329080 Phase 2 Methotrexate;Rituximab;Cytarabine;Thiotepa;liposomial cytarabine;Etoposide;Ifosfamide;Carmustine
4 Study and Surgical Treatment of Syringomyelia Completed NCT00011245
5 Spinal Cord Stimulation (SCS) Therapy Study Withdrawn NCT02371122 Not Applicable

Search NIH Clinical Center for Arachnoiditis

Cochrane evidence based reviews: arachnoiditis

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Genetic Tests for Arachnoiditis

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Anatomical Context for Arachnoiditis

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MalaCards organs/tissues related to Arachnoiditis:

41
Spinal Cord, Brain, Bone, Pituitary, Temporal Lobe, B Cells, Skin
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Publications for Arachnoiditis

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Articles related to Arachnoiditis:

(show top 50) (show all 1251)
# Title Authors Year
1
Temporal arachnoid cysts: are they congenital? ( 29046949 )
2018
2
Arachnoid diverticulum diagnosis following treatment of cryptococcal meningitis in a dog. ( 29636913 )
2018
3
Giant arachnoid granulation with a thrombosed dural arteriovenous fistula. ( 29950364 )
2018
4
Arachnoid cysts and subdural hygroma. ( 29891233 )
2018
5
Letter to the Editor Regarding "Anatomic Dissection of Arachnoid Membranes Encircling the Pituitary Stalk on Fresh Non-Formalin-Fixed Specimens: Anatomoradiologic Correlations and Clinical Applications in Craniopharyngioma Surgery". ( 29232813 )
2018
6
Chronic Subdural Hematoma Associated with Congenital Arachnoid Cysts: Management Dilemmas. ( 29974007 )
2018
7
Evaluation of the Communication Between Arachnoid Cysts and Neighboring Cerebrospinal Fluid Spaces by T2W 3D-SPACE With Variant Flip-Angle Technique at 3 T. ( 29787500 )
2018
8
Case Report: Neurobrucellosis with Plastered Spinal Arachnoiditis: A Magnetic Resonance Imaging-Based Report. ( 29345223 )
2018
9
Cervicothoracic arachnoiditis-a rare complication of aneurysmal intracranial subarachnoid haemorrhage. ( 29977608 )
2018
10
Arachnoid isolation sign: A predictive imaging feature of spinal meningioma on CT-myelogram. ( 29549812 )
2018
11
Neurodevelopmental outcomes in children with large temporal arachnoid cysts. ( 29521605 )
2018
12
Spinal adhesive arachnoiditis following the rupture of an Adamkiewicz aneurysm: Literature review and a case illustration. ( 29433818 )
2018
13
The tethered effect of the arachnoid in vago-glossopharyngeal neuralgia: a real associated alternative mechanism? ( 29075903 )
2018
14
Novel Association Between Intrathecal Drug Administration and Arachnoiditis Ossificans. ( 29747017 )
2018
15
Rare Case of Tricompartmental Arachnoid Cyst Spanning Infratentorial, Supratentorial, and Extracranial Compartment and Presenting as Posterior Parietal Meningocele. ( 29698795 )
2018
16
Rare case of diffuse spinal arachnoiditis following a complicated vertebral artery dissection. ( 29605278 )
2018
17
Spontaneous repeated disappearance and recurrence of multiple spinal intradural arachnoid cysts in a child. ( 29325964 )
2018
18
Fatal toxoplasmosis in a southern muriqui (Brachyteles arachnoides) from SALo Paulo state, Brazil: Pathological, immunohistochemical, and molecular characterization. ( 29193137 )
2018
19
Surgical Management of Giant Retrocerebellar Arachnoid Cysts with a Cystoventricular Stent After Long-Term, Independent, and Simultaneous Intracystic and Intraventricular Pressure Monitoring. ( 29625307 )
2018
20
Extensive spinal adhesive arachnoiditis after extradural spinal infection - spinal dura mater is no barrier to inflammation. ( 29883820 )
2018
21
Arachnoid cysts with spontaneous intracystic hemorrhage and associated subdural hematoma: Report of management and follow-up of 2 cases. ( 29904503 )
2018
22
Surgical management of cerebellopontine angle arachnoid cysts associated with hearing deficit in pediatric patients. ( 29171799 )
2018
23
Management of Arachnoid Cysts: A Comprehensive Review. ( 29888162 )
2018
24
Hemorrhagic complications of arachnoid cysts: When, Why and Who? ( 29410376 )
2018
25
Clinical and radiological features of spinal extradural arachnoid cysts: Valve-like mechanism involving the nerve root fiber as a possible cause of cyst expansion. ( 29452792 )
2018
26
The Transcondylar Approach to Access Symptomatic Arachnoid Cysts of the Hypoglossal Canal. ( 29351690 )
2018
27
Delayed Spinal Arachnoiditis Following Aneurysmal Subarachnoid Hemorrhage: A Case Report. ( 29535904 )
2018
28
Letter to the Editor. Radiographic differentiation of idiopathic spinal cord herniation versus dorsal arachnoid webs. ( 29701570 )
2018
29
Toxic Myelitis and Arachnoiditis After Intrathecal Delivery of Bupivacaine via an Implanted Drug Delivery System: Case Report and Review of the Literature. ( 29719742 )
2018
30
In Reply to the Letter to the Editor Regarding "Anatomic Dissection of Arachnoid Membranes Encircling the Pituitary Stalk on Fresh Non-Formalin-Fixed Specimens: Anatomoradiologic Correlations and Clinical Applications in Craniopharyngioma Surgery". ( 29232814 )
2018
31
Development of Neuromyelitis Optica Spectrum Disorder and Spinal Arachnoid Cysts in a Patient With Intractable Epilepsy. ( 29379967 )
2018
32
Antenatally diagnosed pre-pontine arachnoid cysts with significant post-natal supratentorial progression: report of two cases. ( 28918519 )
2017
33
Bobble-head doll syndrome in an 80-year-old man, associated with a giant arachnoid cyst of the lamina quadrigemina, treated with endoscopic ventriculocystocisternotomy and cystoperitoneal shunt. ( 28488069 )
2017
34
A New Classification for Pathologies of Spinal Meninges-Part 2: Primary and Secondary Intradural Arachnoid Cysts. ( 28327950 )
2017
35
Altered cerebrospinal fluid dynamics in neurofibromatosis type l: severe arachnoid thickening in patients with neurofibromatosis type 1 may cause abnormal CSF dynamic. ( 28332154 )
2017
36
Genetic associations of intracranial aneurysm formation and sub-arachnoid hemorrhage. ( 28761511 )
2017
37
Conus Medullaris Arachnoid Cyst Presenting as Cauda Equina Syndrome. ( 29114289 )
2017
38
Recovery of Tinnitus and Sensorineural Hearing Loss Due to Lysis of Arachnoid Adhesions in the Posterior Cranial Fossa: Is There a Novel Etiology in Neurotological Disorders? ( 28816700 )
2017
39
Management of quadrigeminal arachnoid cyst associated with obstructive hydrocephalus: report on stereotactic ventricular - cystic stenting. ( 28643523 )
2017
40
Long-term endocrine outcome of suprasellar arachnoid cysts. ( 28338427 )
2017
41
Late-Onset Non-HLH Presentations of Growth Arrest, Inflammatory Arachnoiditis, and Severe Infectious Mononucleosis, in Siblings with Hypomorphic Defects in UNC13D. ( 28848550 )
2017
42
Endoscopic treatment of middle fossa arachnoid cysts. ( 28905234 )
2017
43
Treatment of syringomyelia in patients with arachnoiditis at the cranio-cervical junction. ( 28842236 )
2017
44
Letter re: Tuberculous optochiasmatic arachnoiditis and vision loss. ( 28416619 )
2017
45
Anatomic dissection of arachnoid membranes encircling the pituitary stalk on fresh non formalin fixed specimens: anatomo-radiologic correlations and clinical applications in craniopharyngioma surgery. ( 28774763 )
2017
46
Surgical Management of Syringomyelia Associated with Spinal Adhesive Arachnoiditis, a Late Complication of Tuberculous Meningitis: A Case Report. ( 28512616 )
2017
47
Does subjective improvement in adults with intracranial arachnoid cysts justify surgical treatment? ( 28298013 )
2017
48
Idiopathic intradural dorsal thoracic arachnoid cysts: A case series and review of the literature. ( 28318981 )
2017
49
Dual lumbar bronchogenic and arachnoid cyst presenting with sciatica and left foot drop. ( 28762109 )
2017
50
Intrathecal hematoma and arachnoiditis mimicking bacterial meningitis after an epidural blood patch. ( 28689621 )
2017
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Variations for Arachnoiditis

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Expression for Arachnoiditis

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Search GEO for disease gene expression data for Arachnoiditis.
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Pathways for Arachnoiditis

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GO Terms for Arachnoiditis

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Sources for Arachnoiditis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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