MCID: ARC002
MIFTS: 41

Arachnoiditis

Categories: Genetic diseases, Nephrological diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Arachnoiditis

MalaCards integrated aliases for Arachnoiditis:

Name: Arachnoiditis 12 77 54 45 15 74
Familial Spinal Arachnoiditis 74
Spinal Arachnoiditis 54

Classifications:



Summaries for Arachnoiditis

NIH Rare Diseases : 54 Arachnoiditis is a pain disorder caused by inflammation of the arachnoid, one of the membranes that surrounds and protects the nerves of the spinal cord. The inflammation may occur due to irritation from chemicals; infection; direct injury to the spine; chronic compression of spinal nerves; or complications from spinal surgery or other spinal procedures. It may result in scar tissue and adhesions, which cause the spinal nerves to �??stick�?� together. If arachnoiditis affects the function of nerves, it can cause symptoms such as numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs. In some people. it may affect the bladder, bowel, and sexual function. Very severe arachnoiditis can result in paralysis of the legs. Treatment aims to relieve pain and improve symptoms that impair function. Treatment may include pain medications, physical therapy, and psychotherapy. Surgical treatment is controversial because it offers only short-term relief and may increase formation of scar tissue.

MalaCards based summary : Arachnoiditis, also known as familial spinal arachnoiditis, is related to glossopharyngeal neuralgia and arachnoid cysts. An important gene associated with Arachnoiditis is ACAA1 (Acetyl-CoA Acyltransferase 1). The drugs Bupivacaine and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related phenotypes are muscle weakness and hearing impairment

NINDS : 55 Arachnoiditis is caused by the inflammation of the arachnoid, one of the membranes that surround and protect the nerves of the spinal cord.  The arachnoid can become inflamed because of an irritation from chemicals, infection from bacteria or viruses, as the result of direct injury to the spine, chronic compression of spinal nerves, or complications from spinal surgery or other invasive spinal procedures.  Inflammation can sometimes lead to the formation of scar tissue and adhesions, which cause the spinal nerves to “stick” together. If arachnoiditis begins to interfere with the function of one or more of these nerves, it can cause a number of symptoms, including chronic and persistent pain,  numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs.  Some people with arachnoiditis will have debilitating muscle cramps, twitches, or spasms.  It may also affect bladder, bowel, and sexual function.  In severe cases, arachnoiditis may cause paralysis of the lower limbs.

Wikipedia : 77 Arachnoiditis is an inflammatory condition of the arachnoid mater or ''arachnoid'', one of the membranes... more...

Related Diseases for Arachnoiditis

Diseases related to Arachnoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 330)
# Related Disease Score Top Affiliating Genes
1 glossopharyngeal neuralgia 29.2 CRLF1 POMC
2 arachnoid cysts 12.8
3 spinal intradural arachnoid cysts 12.6
4 tibia absent polydactyly arachnoid cyst 12.5
5 spinal arachnoiditis 12.4
6 arachnoid cysts, intracranial 12.3
7 pachygyria with mental retardation, seizures, and arachnoid cysts 12.3
8 tibia, absence or hypoplasia of, with polydactyly, retrocerebellar arachnoid cyst, and other anomalies 12.1
9 syringomyelia 11.6
10 intracranial cysts 11.5
11 meningioma, familial 11.5
12 melanosis, neurocutaneous 11.5
13 chudley-mccullough syndrome 11.4
14 meningitis 11.4
15 autosomal dominant polycystic kidney disease 11.3
16 craniopharyngioma 11.3
17 dandy-walker complex 11.3
18 amyloidosis, hereditary, transthyretin-related 11.0
19 polycystic kidney disease 1 with or without polycystic liver disease 11.0
20 syringomyelia, noncommunicating isolated 11.0
21 acrocallosal syndrome 11.0
22 encephalocraniocutaneous lipomatosis 11.0
23 pachygyria-intellectual disability-epilepsy syndrome 11.0
24 tarlov cysts 11.0
25 hydrocephalus 10.5
26 headache 10.3
27 congenital hydrocephalus 10.3
28 tuberculous meningitis 10.2
29 cauda equina syndrome 10.2
30 intracranial hypertension 10.2
31 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
32 epilepsy 10.2
33 precocious puberty 10.2
34 spondyloarthropathy 1 10.1
35 trigeminal neuralgia 10.1
36 spondylitis 10.1
37 hydrocephalus, normal-pressure 10.1
38 spinal meningioma 10.1
39 acoustic neuroma 10.1
40 neuropathy 10.1
41 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.1
42 sensorineural hearing loss 10.1
43 communicating hydrocephalus 10.1
44 secretory meningioma 10.1
45 kidney disease 10.1
46 polycystic kidney disease 10.1
47 chiari malformation 10.1
48 glioma 10.1
49 schizophrenia 10.0
50 paraplegia 10.0

Graphical network of the top 20 diseases related to Arachnoiditis:



Diseases related to Arachnoiditis

Symptoms & Phenotypes for Arachnoiditis

Human phenotypes related to Arachnoiditis:

33 (show all 13)
# Description HPO Frequency HPO Source Accession
1 muscle weakness 33 hallmark (90%) HP:0001324
2 hearing impairment 33 hallmark (90%) HP:0000365
3 abnormality of vision 33 hallmark (90%) HP:0000504
4 arthralgia 33 hallmark (90%) HP:0002829
5 paresthesia 33 hallmark (90%) HP:0003401
6 meningitis 33 hallmark (90%) HP:0001287
7 hyporeflexia 33 hallmark (90%) HP:0001265
8 tinnitus 33 hallmark (90%) HP:0000360
9 anhidrosis 33 frequent (33%) HP:0000970
10 hydrocephalus 33 occasional (7.5%) HP:0000238
11 fatigue 33 occasional (7.5%) HP:0012378
12 urinary bladder sphincter dysfunction 33 occasional (7.5%) HP:0002839
13 migraine 33 occasional (7.5%) HP:0002076

GenomeRNAi Phenotypes related to Arachnoiditis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-150 9.56 TFG
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 9.56 ACAA1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.56 ACAA1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.56 TFG
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.56 TFG
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.56 ACAA1 TFG
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.56 ACAA1
8 Increased transferrin (TF) endocytosis GR00363-A 9.02 ACAA1 CRLF1 HSF4 MRI1 POMC

Drugs & Therapeutics for Arachnoiditis

Drugs for Arachnoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4 Antineoplastic Agents, Hormonal Phase 4
5 BB 1101 Phase 4
6 Hormones Phase 4
7 Peripheral Nervous System Agents Phase 4
8 Anti-Inflammatory Agents Phase 4
9 HIV Protease Inhibitors Phase 4
10 Autonomic Agents Phase 4
11 Anesthetics, Local Phase 4
12 glucocorticoids Phase 4
13 Gastrointestinal Agents Phase 4
14
protease inhibitors Phase 4
15 Antiemetics Phase 4
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
17 Central Nervous System Depressants Phase 4
18 Hormone Antagonists Phase 4
19 Anesthetics Phase 4
20
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
21
Cytarabine Approved, Experimental, Investigational Phase 2 147-94-4, 65-46-3 6253
22
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
23
Busulfan Approved, Investigational Phase 2 55-98-1 2478
24
Carmustine Approved, Investigational Phase 2 154-93-8 2578
25
Clonazepam Approved, Illicit Phase 2 1622-61-3 2802
26
leucovorin Approved Phase 2 58-05-9 143 6006
27
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
28
Etoposide Approved Phase 2 33419-42-0 36462
29
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
30
rituximab Approved Phase 2 174722-31-7 10201696
31
Ifosfamide Approved Phase 2 3778-73-2 3690
32
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
33
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
34
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
35 Immunosuppressive Agents Phase 2
36 Anti-Infective Agents Phase 2
37 Angiogenesis Inhibitors Phase 2
38 Anti-Bacterial Agents Phase 2
39 Immunologic Factors Phase 2
40 Angiogenesis Modulating Agents Phase 2
41 Dermatologic Agents Phase 2
42 Antineoplastic Agents, Alkylating Phase 2
43 Vitamin B9 Phase 2
44
Isophosphamide mustard Phase 2 0
45 Antimetabolites, Antineoplastic Phase 2
46 Nucleic Acid Synthesis Inhibitors Phase 2
47 Hydrocortisone hemisuccinate Phase 2
48 Alkylating Agents Phase 2
49 Antiviral Agents Phase 2
50 Vitamin B Complex Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dexamethasone & Bupivacaine vs Bupivacaine Alone in Combined Femoral and Sciatic Nerve Block for Perioperative Analgesia in Patients Undergoing Lower Limb Surgeries Completed NCT02576782 Phase 4 Perineural Dexamethasone and bupivacaine;Systemic Dexamethasone plus perineural bupivacaine;intravenous saline plus perineural bupivacaine
2 Use of Thalidomide in Patients With Arachnoiditis Completed NCT00284505 Phase 2 thalidomide
3 New Combination of Chemoimmunotherapy for Systemic B-cell Lymphoma With Central Nervous System Involvement Active, not recruiting NCT02329080 Phase 2 Methotrexate;Rituximab;Cytarabine;Thiotepa;liposomial cytarabine;Etoposide;Ifosfamide;Carmustine
4 Study to Investigate the Efficacy and Safety of Cannabis Oil for the Treatment of Subjects With Hidradenitis Suppurativa Not yet recruiting NCT03929835 Phase 2 Cannabis oil;Placebo
5 Study and Surgical Treatment of Syringomyelia Completed NCT00011245
6 Spinal Cord Stimulation (SCS) Therapy Study Withdrawn NCT02371122 Not Applicable

Search NIH Clinical Center for Arachnoiditis

Cochrane evidence based reviews: arachnoiditis

Genetic Tests for Arachnoiditis

Anatomical Context for Arachnoiditis

MalaCards organs/tissues related to Arachnoiditis:

42
Spinal Cord, Brain, Bone, Pituitary, Kidney, B Cells, Myeloid

Publications for Arachnoiditis

Articles related to Arachnoiditis:

(show top 50) (show all 482)
# Title Authors Year
1
Spinal Arachnoiditis Ossificans: Report of Quadruple-Triggered Case. ( 30521955 )
2019
2
Can an inflammatory reaction in the meninges, caused by spinal puncture through tattooed skin, evolve into adhesive arachnoiditis? An experimental model in rabbits. ( 30635505 )
2019
3
A rare cause of progressive neuropathy: Arachnoiditis ossificans. ( 30706872 )
2019
4
Adhesive arachnoiditis following lumbar epidural steroid injections: a report of two cases and review of the literature. ( 30774420 )
2019
5
Arachnoiditis Ossificans: a Rare Etiology of Oil-Based Spinal Myelography and Review of Literature. ( 30862590 )
2019
6
A Case of Spontaneous Spinal Subdural Hematoma Complicated by Cranial Subarachnoid Hemorrhage and Spinal Adhesive Arachnoiditis. ( 31001442 )
2019
7
Adhesive arachnoiditis secondary to the use of intrathecal liposoluble contrast. ( 29269177 )
2018
8
Case Report: Neurobrucellosis with Plastered Spinal Arachnoiditis: A Magnetic Resonance Imaging-Based Report. ( 29345223 )
2018
9
Spinal adhesive arachnoiditis following the rupture of an Adamkiewicz aneurysm: Literature review and a case illustration. ( 29433818 )
2018
10
Delayed Spinal Arachnoiditis Following Aneurysmal Subarachnoid Hemorrhage: A Case Report. ( 29535904 )
2018
11
Rare case of diffuse spinal arachnoiditis following a complicated vertebral artery dissection. ( 29605278 )
2018
12
Toxic Myelitis and Arachnoiditis After Intrathecal Delivery of Bupivacaine via an Implanted Drug Delivery System: Case Report and Review of the Literature. ( 29719742 )
2018
13
Novel Association Between Intrathecal Drug Administration and Arachnoiditis Ossificans. ( 29747017 )
2018
14
Extensive Spinal Adhesive Arachnoiditis After Extradural Spinal Infection-Spinal Dura Mater Is No Barrier to Inflammation. ( 29883820 )
2018
15
Cervicothoracic arachnoiditis-a rare complication of aneurysmal intracranial subarachnoid haemorrhage. ( 29977608 )
2018
16
Adhesive arachnoiditis following inadvertent epidural injection of 2% chlorhexidine in 70% alcohol-partial recovery over the ensuing eight years. ( 30447665 )
2018
17
Neural Mobilization in a 54-Year-Old Woman With Postoperative Spinal Adhesive Arachnoiditis. ( 30846922 )
2018
18
Tuberculous optochiasmatic arachnoiditis and vision loss. ( 28416621 )
2017
19
Surgical Management of Syringomyelia Associated with Spinal Adhesive Arachnoiditis, a Late Complication of Tuberculous Meningitis: A Case Report. ( 28512616 )
2017
20
Imaging Appearance of Advanced Chronic Adhesive Arachnoiditis: A Retrospective Review. ( 28639826 )
2017
21
Intrathecal hematoma and arachnoiditis mimicking bacterial meningitis after an epidural blood patch. ( 28689621 )
2017
22
Intradural Extramedullary Capillary Hemangioma In the Upper Thoracic Spine with Simultaneous Extensive Arachnoiditis. ( 28704911 )
2017
23
Treatment of Syringomyelia in Patients with Arachnoiditis at the Craniocervical Junction. ( 28842236 )
2017
24
Late-Onset Non-HLH Presentations of Growth Arrest, Inflammatory Arachnoiditis, and Severe Infectious Mononucleosis, in Siblings with Hypomorphic Defects in UNC13D. ( 28848550 )
2017
25
Arachnoiditis ossificans associated with syringomyelia: a case report. ( 29092643 )
2017
26
Patterns of chronic inflammation in extensively treated patients with arachnoiditis and chronic intractable pain. ( 27929717 )
2017
27
Spinal Arachnoiditis as a Complication of Cryptococcal Meningoencephalitis in Non-HIV Previously Healthy Adults. ( 28011613 )
2017
28
Letter re: Tuberculous optochiasmatic arachnoiditis and vision loss. ( 28416619 )
2017
29
Author response: Tuberculous optochiasmatic arachnoiditis and vision loss. ( 28416620 )
2017
30
Post-traumatic Focal Adhesive Arachnoiditis. ( 30039004 )
2017
31
Post-procedure adhesive arachnoiditis following obstetric spinal anaesthesia. ( 27212734 )
2016
32
Acquired Chiari malformation secondary to tuberculous arachnoiditis of the lumbar spine. ( 27625266 )
2016
33
Tuberculous optochiasmatic arachnoiditis and vision loss. ( 27777344 )
2016
34
Spinal intradural hydatid cyst causing arachnoiditis: A rare etiology of cauda equina syndrome. ( 27891041 )
2016
35
Adhesive arachnoiditis in mixed connective tissue disease: a rare neurological manifestation. ( 27986694 )
2016
36
A Case of Lumbosacral Arachnoiditis Ossificans. ( 28663987 )
2016
37
Aseptic arachnoiditis in a patient treated with intrathecal morphine infusion: symptom resolution on switch to ziconotide. ( 24945709 )
2015
38
Spinal arachnoid cyst associated with arachnoiditis following subarachnoid haemorrhage in adult patients: A case report and literature review. ( 25365662 )
2015
39
A neuroimaging case of chronic arachnoiditis. ( 25917427 )
2015
40
Arachnoiditis ossificans after spinal surgery. ( 25970374 )
2015
41
Chronic adhesive arachnoiditis after repeat epidural blood patch. ( 26119259 )
2015
42
Arachnoiditis Ossificans - A Rare Cause of Progressive Myelopathy. ( 26401174 )
2015
43
Arachnoiditis ossificans and syringomyelia: A unique presentation. ( 26693389 )
2015
44
Arachnoiditis ossificans of the thoracic spine. ( 24291474 )
2014
45
MRI and FDG PET/CT findings in 3 cases of spinal infectious arachnoiditis. ( 24321827 )
2014
46
Symptomatic spinal cord kinking due to focal adhesive arachnoiditis, with ossification of the ligamentum flavum: a case report. ( 24480938 )
2014
47
Familial adhesive arachnoiditis associated with syringomyelia. ( 24481329 )
2014
48
Delayed visual loss from optochiasmatic arachnoiditis after resection of craniopharyngioma. ( 24606404 )
2014
49
Adhesive arachnoiditis after percutaneous fibrin glue treatment of a sacral meningeal cyst. ( 24702510 )
2014
50
Tuberculous optochiasmatic arachnoiditis. ( 24926172 )
2014

Variations for Arachnoiditis

Expression for Arachnoiditis

Search GEO for disease gene expression data for Arachnoiditis.

Pathways for Arachnoiditis

GO Terms for Arachnoiditis

Sources for Arachnoiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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