MCID: ARC002
MIFTS: 42

Arachnoiditis

Categories: Genetic diseases, Nephrological diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Arachnoiditis

MalaCards integrated aliases for Arachnoiditis:

Name: Arachnoiditis 12 74 52 53 43 15 71
Familial Spinal Arachnoiditis 71
Spinal Arachnoiditis 52

Classifications:



Summaries for Arachnoiditis

NIH Rare Diseases : 52 Arachnoiditis is a pain disorder caused by inflammation of the arachnoid, one of the membranes that surrounds and protects the nerves of the spinal cord. The inflammation may occur due to irritation from chemicals; infection; direct injury to the spine; chronic compression of spinal nerves; or complications from spinal surgery or other spinal procedures. It may result in scar tissue and adhesions, which cause the spinal nerves to "stick" together. If arachnoiditis affects the function of nerves, it can cause symptoms such as numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs. In some people. it may affect the bladder, bowel, and sexual function. Very severe arachnoiditis can result in paralysis of the legs. Treatment aims to relieve pain and improve symptoms that impair function. Treatment may include pain medications, physical therapy , and psychotherapy. Surgical treatment is controversial because it offers only short-term relief and may increase formation of scar tissue.

MalaCards based summary : Arachnoiditis, also known as familial spinal arachnoiditis, is related to syringomyelia and cauda equina syndrome. An important gene associated with Arachnoiditis is RPL34 (Ribosomal Protein L34), and among its related pathways/superpathways is Development_Leptin signaling via JAK/STAT and MAPK cascades. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related phenotypes are hearing impairment and muscle weakness

NINDS : 53 Arachnoiditis is caused by the inflammation of the arachnoid, one of the membranes that surround and protect the nerves of the spinal cord.  The arachnoid can become inflamed because of an irritation from chemicals, infection from bacteria or viruses, as the result of direct injury to the spine, chronic compression of spinal nerves, or complications from spinal surgery or other invasive spinal procedures.  Inflammation can sometimes lead to the formation of scar tissue and adhesions, which cause the spinal nerves to “stick” together. If arachnoiditis begins to interfere with the function of one or more of these nerves, it can cause a number of symptoms, including chronic and persistent pain,  numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs.  Some people with arachnoiditis will have debilitating muscle cramps, twitches, or spasms.  It may also affect bladder, bowel, and sexual function.  In severe cases, arachnoiditis may cause paralysis of the lower limbs.

Wikipedia : 74 Arachnoiditis is an inflammatory condition of the arachnoid mater or 'arachnoid', one of the membranes... more...

Related Diseases for Arachnoiditis

Diseases related to Arachnoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 688)
# Related Disease Score Top Affiliating Genes
1 syringomyelia 32.4 RICTOR CYREN CRLF1 AQP4
2 cauda equina syndrome 31.0 RPL34 PPP3R2 CRP
3 intracranial hypotension 31.0 RPL34 CRLF1
4 obstructive hydrocephalus 31.0 RICTOR CRLF1 AQP4
5 trigeminal neuralgia 30.8 TAC1 CRLF1
6 epidural abscess 30.7 RPL34 CRP
7 meningocele 30.7 RPL34 CRLF1
8 communicating hydrocephalus 30.5 ASPRV1 AQP4
9 pain agnosia 30.4 TAC1 RPL34 POMC
10 spondylolisthesis 30.4 RPL34 CRP
11 papilledema 30.3 CRP CD4
12 intracranial hypertension, idiopathic 30.3 POMC ASPRV1 AQP4
13 lumbosacral lipoma 30.2 RPL34 RICTOR
14 abducens nerve disease 30.1 POMC CRP AQP4
15 glossopharyngeal neuralgia 30.1 TAC1 POMC CRLF1
16 facial paralysis 30.0 CRP CRLF1 CD4
17 migraine with or without aura 1 29.8 TAC1 POMC CRP AQP4
18 cysticercosis 29.8 CRLF1 CD4
19 mononeuropathy 29.8 TAC1 RPL34 CRP
20 polyradiculopathy 29.8 TAC1 RPL34 CRP
21 cranial nerve palsy 29.7 POMC CRP CD4 AQP4
22 mastoiditis 29.7 CRP CD4
23 optic nerve disease 29.7 CRP CD4 AQP4
24 neurosarcoidosis 29.5 CRP CD4 AQP4
25 miliary tuberculosis 29.4 CRP CD4
26 pleural empyema 29.4 CRP CD4
27 subdural empyema 29.3 RPL34 CYREN CRP ASPRV1
28 meningoencephalitis 29.3 TAC1 CRP CD4
29 spinal cord disease 28.9 RICTOR CRP CD4 AQP4
30 arachnoid cysts, intracranial 12.9
31 spinal intradural arachnoid cysts 12.7
32 tibia, absence or hypoplasia of, with polydactyly, retrocerebellar arachnoid cyst, and other anomalies 12.7
33 spinal arachnoiditis 12.6
34 pachygyria with mental retardation, seizures, and arachnoid cysts 12.5
35 intracranial cysts 12.0
36 chudley-mccullough syndrome 11.9
37 meningioma, familial 11.6
38 melanosis, neurocutaneous 11.6
39 syringomyelia, noncommunicating isolated 11.6
40 meningitis 11.5
41 meningioma, radiation-induced 11.5
42 normal pressure hydrocephalus 11.5
43 craniopharyngioma 11.5
44 dandy-walker syndrome 11.5
45 amyloidosis, hereditary, transthyretin-related 11.1
46 polycystic kidney disease 1 with or without polycystic liver disease 11.1
47 acrocallosal syndrome 11.1
48 encephalocraniocutaneous lipomatosis 11.1
49 tarlov cysts 11.1
50 slc35a2-congenital disorder of glycosylation 11.1

Graphical network of the top 20 diseases related to Arachnoiditis:



Diseases related to Arachnoiditis

Symptoms & Phenotypes for Arachnoiditis

Human phenotypes related to Arachnoiditis:

31 (show all 13)
# Description HPO Frequency HPO Source Accession
1 hearing impairment 31 hallmark (90%) HP:0000365
2 muscle weakness 31 hallmark (90%) HP:0001324
3 arthralgia 31 hallmark (90%) HP:0002829
4 abnormality of vision 31 hallmark (90%) HP:0000504
5 paresthesia 31 hallmark (90%) HP:0003401
6 meningitis 31 hallmark (90%) HP:0001287
7 hyporeflexia 31 hallmark (90%) HP:0001265
8 tinnitus 31 hallmark (90%) HP:0000360
9 anhidrosis 31 frequent (33%) HP:0000970
10 hydrocephalus 31 occasional (7.5%) HP:0000238
11 fatigue 31 occasional (7.5%) HP:0012378
12 migraine 31 occasional (7.5%) HP:0002076
13 urinary bladder sphincter dysfunction 31 occasional (7.5%) HP:0002839

Drugs & Therapeutics for Arachnoiditis

Drugs for Arachnoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
4 Hormones Phase 4
5 Antineoplastic Agents, Hormonal Phase 4
6 Hormone Antagonists Phase 4
7 Antiemetics Phase 4
8
protease inhibitors Phase 4
9 HIV Protease Inhibitors Phase 4
10 glucocorticoids Phase 4
11 Gastrointestinal Agents Phase 4
12 BB 1101 Phase 4
13 Anti-Inflammatory Agents Phase 4
14 Immunologic Factors Phase 2
15 Angiogenesis Inhibitors Phase 2
16 Immunosuppressive Agents Phase 2
17 Anti-Infective Agents Phase 2
18 Anti-Bacterial Agents Phase 2
19 Olive Phase 2
20 chlorophyllin Phase 2
21 Epidiolex Phase 2
22
Chloroprocaine Approved 133-16-4 8612
23
Nabilone Approved, Investigational 51022-71-0 5284592
24
Lidocaine Approved, Vet_approved 137-58-6 3676
25 Anti-Anxiety Agents
26 Psychotropic Drugs
27 Anesthetics
28 Anesthetics, Local

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Combination of Dexamethasone and Bupivacaine Versus Bupivacaine Alone in Combined Femoral and Sciatic Nerve Block for Intraoperative and Postoperative Analgesia in Patients Undergoing Lower Limb Vascular Surgeries Completed NCT02576782 Phase 4 Perineural Dexamethasone and bupivacaine;Systemic Dexamethasone plus perineural bupivacaine;intravenous saline plus perineural bupivacaine
2 Prospective Study of the Use of Thalidomide in Patients With Arachnoiditis Completed NCT00284505 Phase 2 thalidomide
3 A Randomized, Double-Blind Study to Evaluate the Effect of Epiduroscopy and Ozone Therapy in Patients With Failed Back Surgery Syndrome Completed NCT01172457 Phase 2
4 A Phase Ⅱ, Randomized, Double-blind, Placebo-controlled Study to Investigate the Efficacy and Safety of Cannabis Oil for the Treatment of Subjects With Hidradenitis Suppurativa Not yet recruiting NCT03929835 Phase 2 Cannabis oil;Placebo
5 OBSERVATIONAL PROSPECTIVE STUDY ON 2-CHLOROPROCAINE HYDROCHLORIDE 1% SAFETY IN INTRATHECAL ANAESTHESIA Completed NCT02067806 Spinal administration of chloroprocaine
6 Nabilone and THC/CBD for the Treatment of FBSS Refractory Pain Completed NCT03210766 Nabilone;THC/CBD
7 Establishing the Pathophysiology of Primary Spinal Syringomyelia Completed NCT00011245
8 The Effect of Intradermal Local Anesthetic Injection on Pain and Functionality in Failed Back Surgery Syndrome Not yet recruiting NCT04268602
9 miRNA Markers of Hydrocephalus in Intraventricular Hemorrhage (IVH) Terminated NCT02386228
10 Spinal Cord Stimulation (SCS) Therapy Study Withdrawn NCT02371122

Search NIH Clinical Center for Arachnoiditis

Cochrane evidence based reviews: arachnoiditis

Genetic Tests for Arachnoiditis

Anatomical Context for Arachnoiditis

MalaCards organs/tissues related to Arachnoiditis:

40
Spinal Cord, Brain, Bone, Cortex, Skin, Testes, Cerebellum

Publications for Arachnoiditis

Articles related to Arachnoiditis:

(show top 50) (show all 1547)
# Title Authors PMID Year
1
The long-range prognosis of arachnoiditis. 52 61
2617363 1989
2
Recurrent arachnoid cysts secondary to spinal adhesive arachnoiditis successfully treated with a ventriculoperitoneal shunt. 61
32305826 2020
3
Dark as night: Spelunking for spinal solitary fibrous tumors/hemangiopericytomas in the differential of T2 hypointensity. 61
32507710 2020
4
Spinal adhesive arachnoiditis mimicking sarcoid myelitis with nodular dural enhancement: A case report. 61
32535503 2020
5
Syringomyelia as a delayed complication of lumbar-sacral adhesive arachnoiditis in Pott's disease. 61
32467119 2020
6
Syringomyelia in the Tethered Spinal Cords. 61
32336060 2020
7
Optic nerve sheath diameter ultrasonography for elevated intracranial pressure detection. 61
32383326 2020
8
Antisepsis for neuraxial procedures in Irish obstetric units and its possible impact on patient safety. A survey of national practice and associated complications. 61
31917052 2020
9
Compressive myelopathy secondary to posthemorragic arachnoiditis: Case report and literature review. 61
32526489 2020
10
Lumbar arachnoiditis: Does imaging associate with clinical features? 61
32062307 2020
11
Ruptured dermoid cyst of the conus medullaris in the myelomeningocele sac revealed at the initial repair surgery. 61
31776717 2020
12
A Case of Severe Cryptococcal Immune Reconstitution Inflammatory Syndrome Presenting with Brain and Intradural Abscesses in an HIV Patient. 61
32342852 2020
13
Minimally invasive foramen magnum durectomy and obexostomy for treatment of craniocervical junction-related syringomyelia in adults: case series and midterm follow-up. 61
32302978 2020
14
Successful Treatment of a Severe Vision-Threatening Paradoxical Tuberculous Reaction with Infliximab: First Pediatric Use. 61
31939874 2020
15
Polyclonal lymphocytic infiltrate with arachnoiditis resulting from intrathecal stem cell transplantation. 61
32013747 2020
16
Multiple Intracranial Tuberculomas with an Intra-medullary Spinal Cord Tuberculoma in a Pediatric Patient. 61
32292663 2020
17
Abnormalities in spinal cord ultrastructure in a rat model of post-traumatic syringomyelia. 61
32111246 2020
18
Prolonged inflammation leads to ongoing damage after spinal cord injury. 61
32191733 2020
19
Natural History of Treated Subarachnoid Neurocysticercosis. 61
31642423 2020
20
Correction to: Arachnoiditis as an outcome factor for microvascular decompression in classical trigeminal neuralgia. 61
31748899 2020
21
A Novel Technique Using Magnetic Resonance Imaging in the Supine and Prone Positions for Diagnosing Lumbar Adhesive Arachnoiditis: A Preliminary Study. 61
31325409 2020
22
Safety and Efficacy of Syringoperitoneal Shunting with a Programmable Shunt Valve for Syringomyelia Associated with Extensive Spinal Adhesive Arachnoiditis: Technical Note. 61
31465850 2019
23
Arachnoiditis ossificans associated with syringomyelia: a case report. 61
29092643 2019
24
Complications and liability related to regional and neuraxial anesthesia. 61
31791565 2019
25
Cerebrospinal fluid biomarkers of inflammation in trigeminal neuralgia patients operated with microvascular decompression. 61
31373951 2019
26
Endoscopic-Assisted Spinal Arachnoiditis Adhesiolysis and Placement of a Spinal Cysto-Subarachnoid Shunt. 61
31362104 2019
27
Craniovertebral Junction Arachnoiditis: An Unusual Sequelae to Tuberculous Meningitis. 61
31831994 2019
28
Arachnoiditis Ossificans of the Lumbosacral Spine. 61
31572998 2019
29
Widening the spectrum of secondary headache: intracranial hypotension following a non-aneurysmal subarachnoid hemorrhage. 61
30847675 2019
30
A two-level large-volume epidural blood patch protocol for spontaneous intracranial hypotension: retrospective analysis of risk and benefit. 61
31541008 2019
31
Intradural cauda equina Candida abscess presenting with hydrocephalus: case report. 61
31470401 2019
32
Combination therapy with ciprofloxacin and third-generation cephalosporin versus third-generation cephalosporin monotherapy in Escherichia coli meningitis in infants: a multicentre propensity score-matched observational study. 61
30593862 2019
33
Arachnoiditis as an outcome factor for microvascular decompression in classical trigeminal neuralgia. 61
31240582 2019
34
[A case of tuberculous meningitis with pleural effusion as a manifestation of a paradoxical reaction during anti-tuberculosis therapy]. 61
31341131 2019
35
Central Nervous System Infections Due to Coccidioidomycosis. 61
31261704 2019
36
Giant intradural extramedullary spinal ependymoma, a rare arachnoiditis-mimicking condition: case report and literature review. 61
31213094 2019
37
Central Nervous System Tuberculoma Complicated with Spinal Arachnoiditis in Immunocompetent Patient. 61
31406545 2019
38
Thoracal arachnoiditis ossificans associated with multifocal motor neuropathy: a case report. 61
31215253 2019
39
Arachnoiditis Ossificans: A Rare Etiology of Oil-Based Spinal Myelography and Review of the Literature. 61
30862590 2019
40
Spontaneous Intracranial and Lumbar Subdural Hematoma Presenting as Vaginal Pain. 61
30745198 2019
41
Spinal Arachnoiditis Ossificans: Report of Quadruple-Triggered Case. 61
30521955 2019
42
Repeat epidural blood patch at the level of unintentional dural puncture and its neurologic complications: a case report. 61
32025902 2019
43
Multifaceted progressive neurotuberculosis in a single patient: from miliary tuberculomas to cortical venous infarct. 61
31131115 2019
44
Minimally invasive asterional approach for microvascular decompression in trigeminal neuralgia. 61
31638613 2019
45
Safety of intrathecal route: focus to methylprednisolone acetate (Depo-Medrol) use. 61
29151132 2019
46
[Abordaje asterional mínimamente invasivo para descompresión microvascular en neuralgia del trigémino]. 61
31182878 2019
47
Clinical Spectrum of Central Nervous System Tuberculosis and the Efficacy of Revised National Tuberculosis Control Program in its Management. 61
30765974 2019
48
A rare cause of progressive neuropathy: Arachnoiditis ossificans. 61
30706872 2019
49
Can an inflammatory reaction in the meninges, caused by spinal puncture through tattooed skin, evolve into adhesive arachnoiditis? An experimental model in rabbits. 61
30635505 2019
50
Adhesive arachnoiditis following lumbar epidural steroid injections: a report of two cases and review of the literature. 61
30774420 2019

Variations for Arachnoiditis

Expression for Arachnoiditis

Search GEO for disease gene expression data for Arachnoiditis.

Pathways for Arachnoiditis

Pathways related to Arachnoiditis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.1 POMC CRP

GO Terms for Arachnoiditis

Sources for Arachnoiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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