Aliases & Classifications for Arcus Corneae

MalaCards integrated aliases for Arcus Corneae:

Name: Arcus Corneae 57
Arcus Senilis 57 12 44 15 73
Corneal Arcus 57 12 55
Arcus of Cornea 12

Classifications:



External Ids:

OMIM 57 107800
Disease Ontology 12 DOID:11342
ICD10 33 H18.41
MeSH 44 D001112
MedGen 42 C0003742
UMLS 73 C0003742

Summaries for Arcus Corneae

MalaCards based summary : Arcus Corneae, also known as arcus senilis, is related to arteriosclerosis and heart disease. An important gene associated with Arcus Corneae is LCAT (Lecithin-Cholesterol Acyltransferase), and among its related pathways/superpathways are Metabolism and Vesicle-mediated transport. Affiliated tissues include eye and heart, and related phenotypes are Decreased free cholesterol and Increased LDL uptake

Wikipedia : 76 Arcus senilis is an old age syndrome where there is a white, grey, or blue opaque ring in the corneal... more...

Description from OMIM: 107800

Related Diseases for Arcus Corneae

Diseases related to Arcus Corneae via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 arteriosclerosis 29.6 APOA1 APOB APOE COG2 LPA
2 heart disease 28.3 ALB APOA1 APOB APOE LDLR
3 coronary artery anomaly 27.8 APOA1 APOA2 APOB APOE CETP COG2
4 coronary heart disease 1 27.2 APOA1 APOA2 APOB APOE CETP COG2
5 arteries, anomalies of 27.1 ALB APOA1 APOB APOE CETP COG2
6 vascular disease 27.1 ALB APOA1 APOB APOE CETP LDLR
7 hypercholesterolemia, familial 26.5 APOA1 APOA2 APOB APOE CETP COG2
8 cornea plana 2, autosomal recessive 11.2
9 apo a-i deficiency 10.8 APOA1 LCAT
10 fish-eye disease 10.6 APOA1 APOA2 LCAT
11 amyloidosis aa 10.5 APOA1 LCAT LPA
12 cholesterol ester storage disease 10.5 APOB COG2 LDLRAP1
13 hypercholesterolemia, autosomal recessive 10.4 LDLR LDLRAP1 PCSK9
14 amyloidosis, familial visceral 10.4 APOA1 APOA2 LPA
15 xanthoma disseminatum 10.4 APOB APOE
16 inherited metabolic disorder 10.3 APOA1 APOB COG2 PCSK9
17 sea-blue histiocyte disease 10.3 APOE LCAT
18 aging 10.3
19 fetal macrosomia 10.3 APOA1 APOB APOM LCAT
20 ischemic heart disease 10.2 APOA1 APOB APOE
21 hypercholesterolemia, autosomal dominant, type b 10.2 APOB APOE LDLR
22 schnyder corneal dystrophy 10.2 APOA2 APOB APOE
23 hepatic lipase deficiency 10.1 APOA1 APOE
24 cerebral atherosclerosis 10.1 APOA1 APOE
25 wrinkles 10.1
26 pinguecula 10.1
27 myopia 10.1
28 hereditary amyloidosis 10.0 APOA1 APOA2
29 defective apolipoprotein b-100 10.0 APOB APOE LCAT LDLR
30 hyperlipoproteinemia, type iv 10.0 APOA1 APOA2 APOB APOE
31 hypertriglyceridemia, familial 10.0 APOA1 APOB CETP LDLR
32 cerebrovascular disease 9.9 APOA1 APOB APOE LDLR
33 prediabetes syndrome 9.8 ALB APOB COG2
34 hypobetalipoproteinemia, familial, 1 9.8 APOA1 APOB APOE LCAT LDLR
35 stroke, ischemic 9.8 APOB APOE COG2 LPA
36 leukodystrophy, hypomyelinating, 3 9.7 APOA1 APOA2 APOB APOE LPA
37 glucose metabolism disease 9.7 ALB APOB COG2
38 carotid artery disease 9.7 APOA1 APOB APOE COG2 LPA
39 acquired metabolic disease 9.7 ALB APOB COG2
40 gallbladder disease 9.7 APOA1 APOB APOE CETP
41 homozygous familial hypercholesterolemia 9.6 APOB APOE LDLR LDLRAP1 PCSK9
42 kwashiorkor 9.6 ALB LCAT
43 xanthomatosis 9.6 APOB APOE LDLR LDLRAP1 LPA
44 peripheral vascular disease 9.6 ALB APOA1 APOB LPA
45 aortic atherosclerosis 9.5 APOE CETP LDLR LPA
46 hypoalphalipoproteinemia, primary 9.5 APOA1 APOA2 APOB CETP LCAT LDLR
47 hypolipoproteinemia 9.5 APOA1 APOA2 APOB APOE LCAT LPA
48 hyperlipidemia, familial combined 9.5 APOA1 APOA2 APOB APOE COG2 LPA
49 abetalipoproteinemia 9.5 APOA1 APOB APOE CETP LCAT
50 lipoprotein glomerulopathy 9.5 APOA2 APOB APOE LCAT LDLR LPA

Graphical network of the top 20 diseases related to Arcus Corneae:



Diseases related to Arcus Corneae

Symptoms & Phenotypes for Arcus Corneae

Clinical features from OMIM:

107800

GenomeRNAi Phenotypes related to Arcus Corneae according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.56 APOA1 APOB APOE CETP LDLR LDLRAP1
2 Increased LDL uptake GR00340-A-1 8.8 APOA1 APOE LDLR

MGI Mouse Phenotypes related to Arcus Corneae:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 ALB APOA1 APOA2 APOB APOE APOM
2 liver/biliary system MP:0005370 9.28 ALB APOA1 APOB APOE FN1 FOXM1

Drugs & Therapeutics for Arcus Corneae

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Biomarker for Homozygous Familial Hypercholesterolemia Recruiting NCT03198897

Search NIH Clinical Center for Arcus Corneae

Cochrane evidence based reviews: arcus senilis

Genetic Tests for Arcus Corneae

Anatomical Context for Arcus Corneae

MalaCards organs/tissues related to Arcus Corneae:

41
Eye, Heart

Publications for Arcus Corneae

Articles related to Arcus Corneae:

(show all 37)
# Title Authors Year
1
Familial hypercholesterolemia: xanthelesma, arcus corneae and tendon xanthomas. ( 28340211 )
2017
2
Corneal Biomechanical Properties in Patients With Arcus Senilis. ( 27124777 )
2016
3
Non-invasive measurement of transparency, arcus senilis, and scleral rim diameter of corneas during eye banking. ( 24306057 )
2013
4
Xanthelasmata, arcus corneae, and ischaemic vascular disease and death in general population: prospective cohort study. ( 21920887 )
2011
5
Arcus senilis and mortality in a population with diabetes. ( 10844069 )
2000
6
Longevity and gray hair, baldness, facial wrinkles, and arcus senilis in 13,000 men and women: the Copenhagen City Heart Study. ( 9754140 )
1998
7
Corneal arcus senilis and dyslipidemia. ( 9617096 )
1998
8
The prevalence of corneal arcus senilis in known insulin-dependent diabetic patients. ( 4020009 )
1985
9
Arcus senilis: an important forensic physical finding. ( 7114015 )
1982
10
Significance of arcus senilis in Caucasians. ( 7205858 )
1981
11
Arcus senilis and alcohol intake. ( 70669 )
1977
12
Letter: Arcus senilis and atherosclerosis in blacks. ( 1110679 )
1975
13
Letter: Arcus senilis and carotid disease. ( 1242181 )
1975
14
Unilateral arcus corneae senilis and carotid occlusive disease. ( 1173857 )
1975
15
Unilateral arcus senilis. ( 4711354 )
1973
16
The cornea at northern latitudes--corneal power, arcus senilis and corneal scars in Eskimos, Lapps and Finns. ( 4707215 )
1973
17
Arcus senilis. ( 4122363 )
1973
18
Alcohol consumption and arcus senilis: a search for a significant relationship. ( 4507258 )
1972
19
The age-prevalence of arcus senilis, greying of hair, and baldness. Etiological considerations. ( 5092816 )
1971
20
Arcus senilis: its relation to certain attributes and risk factors in patients with coronary heart disease. ( 5433305 )
1970
21
Arcus senilis corneae--its relationship to serum lipids in the South African Bantu. ( 5822930 )
1969
22
Arcus senilis and adulthood myopia. ( 6022253 )
1967
23
Significance of arcus senilis under anesthesia. ( 5177119 )
1966
24
Lipid analysis of the human cornea with and without arcus senilis. ( 5946113 )
1966
25
ARCUS SENILIS IN MIDDLE-AGED MEN. ( 14237926 )
1965
26
Arcus senilis and coronary artery disease. ( 5842529 )
1965
27
THE INCIDENCE OF ARCUS SENILIS IN ISCHAEMIC HEART-DISEASE ITS RELATION TO SERUM-LIPID LEVELS. ( 14247887 )
1965
28
A note on blood serum cholesterol levels and arcus senilis. ( 5213294 )
1965
29
Arcus senilis and arteriosclerosis in the aged. ( 13974685 )
1963
30
Pterygium and its relation to arcus senilis, pinguecula and other similar conditions. ( 13958798 )
1962
31
The lipids of arcus senilis. ( 13861495 )
1962
32
Association of specific overt behavior pattern with blood and cardiovascular findings; blood cholesterol level, blood clotting time, incidence of arcus senilis, and clinical coronary artery disease. ( 13630753 )
1959
33
Arcus senilis; its pathology and histochemistry. ( 13636543 )
1959
34
Sensitivity of the cornea in arcus senilis. ( 13532613 )
1958
35
Arcus senilis corneae: its frequency in some ethnic groups. ( 13301643 )
1955
36
Arcus senilis corneae; its clinical development and relationship to serum lipids, proteins and lipoproteins. ( 13227974 )
1954
37
Arcus senilis and serum cholesterol levels in the Aleut. ( 15406082 )
1950

Variations for Arcus Corneae

Expression for Arcus Corneae

Search GEO for disease gene expression data for Arcus Corneae.

Pathways for Arcus Corneae

Pathways related to Arcus Corneae according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 ALB APOA1 APOA2 APOB APOE APOM
2
Show member pathways
13.14 ALB APOA1 APOB APOE APOL1 COG2
3
Show member pathways
12.41 APOA1 APOA2 APOB APOE APOM LDLR
4
Show member pathways
12.23 ALB APOA1 APOA2 APOB APOE CETP
5
Show member pathways
12.13 ALB APOA1 APOB APOE LDLR
6
Show member pathways
11.96 APOA1 APOA2 APOB APOE APOM LDLR
7 11.86 ALB APOA1 APOE APOM
8
Show member pathways
11.67 ALB APOA1 APOB APOE APOL1
9
Show member pathways
11.39 APOA1 APOA2 APOB APOE CETP LCAT
10 11.33 APOB FN1 LPA
11 10.82 APOA1 APOA2 APOL1
12
Show member pathways
10.29 LDLR PCSK9

GO Terms for Arcus Corneae

Cellular components related to Arcus Corneae according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.95 ALB APOA1 APOA2 APOE APOL1 FN1
2 early endosome GO:0005769 9.91 APOA1 APOA2 APOB APOE LDLR LDLRAP1
3 endoplasmic reticulum lumen GO:0005788 9.86 ALB APOA1 APOA2 APOB APOE APOL1
4 clathrin-coated endocytic vesicle membrane GO:0030669 9.73 APOB APOE LDLR
5 endocytic vesicle lumen GO:0071682 9.7 APOA1 APOB APOE
6 spherical high-density lipoprotein particle GO:0034366 9.69 APOA1 APOA2 APOM
7 intermediate-density lipoprotein particle GO:0034363 9.67 APOA1 APOB APOE
8 discoidal high-density lipoprotein particle GO:0034365 9.63 APOA1 APOE APOM
9 chylomicron GO:0042627 9.62 APOA1 APOA2 APOB APOE
10 endolysosome membrane GO:0036020 9.57 LDLR PCSK9
11 low-density lipoprotein particle GO:0034362 9.55 APOA1 APOB APOE APOM LDLR
12 PCSK9-LDLR complex GO:1990666 9.54 LDLR PCSK9
13 very-low-density lipoprotein particle GO:0034361 9.43 APOA1 APOA2 APOB APOE APOL1 APOM
14 high-density lipoprotein particle GO:0034364 9.17 APOA1 APOA2 APOE APOL1 APOM CETP
15 extracellular exosome GO:0070062 10.29 ALB APOA1 APOA2 APOB APOE APOM
16 extracellular region GO:0005576 10.25 ALB APOA1 APOA2 APOB APOE APOL1
17 extracellular space GO:0005615 10.18 ALB APOA1 APOA2 APOB APOE APOL1

Biological processes related to Arcus Corneae according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 cholesterol metabolic process GO:0008203 9.96 APOA1 APOA2 APOB APOE APOL1 CETP
2 triglyceride metabolic process GO:0006641 9.92 APOA2 APOE CETP PCSK9
3 low-density lipoprotein particle clearance GO:0034383 9.91 APOB LDLR LDLRAP1 PCSK9
4 cholesterol efflux GO:0033344 9.91 APOA1 APOA2 APOB APOE APOM
5 reverse cholesterol transport GO:0043691 9.91 APOA1 APOA2 APOE APOM CETP LCAT
6 membrane organization GO:0061024 9.89 APOB LDLR LDLRAP1
7 platelet degranulation GO:0002576 9.89 ALB APOA1 FN1
8 high-density lipoprotein particle assembly GO:0034380 9.89 APOA1 APOA2 APOE APOM
9 cellular oxidant detoxification GO:0098869 9.88 ALB APOE APOM
10 phospholipid metabolic process GO:0006644 9.88 APOA1 LCAT PCSK9
11 chylomicron assembly GO:0034378 9.87 APOA1 APOA2 APOB APOE
12 cholesterol transport GO:0030301 9.87 APOA1 APOA2 APOB CETP LCAT LDLR
13 very-low-density lipoprotein particle remodeling GO:0034372 9.86 APOA1 APOE CETP LCAT
14 phospholipid transport GO:0015914 9.85 APOA1 CETP LDLR
15 high-density lipoprotein particle clearance GO:0034384 9.85 APOA1 APOA2 APOE APOM
16 low-density lipoprotein particle remodeling GO:0034374 9.85 APOA2 APOB APOE CETP LPA
17 cholesterol homeostasis GO:0042632 9.85 APOA1 APOA2 APOB APOE APOM CETP
18 chylomicron remodeling GO:0034371 9.84 APOA1 APOA2 APOB APOE
19 phosphatidylcholine biosynthetic process GO:0006656 9.83 APOA1 APOA2 LCAT
20 triglyceride homeostasis GO:0070328 9.83 APOA1 APOE CETP
21 lipoprotein biosynthetic process GO:0042158 9.83 APOA1 APOB APOE LCAT
22 triglyceride catabolic process GO:0019433 9.82 APOA1 APOB APOE
23 phosphatidylcholine metabolic process GO:0046470 9.81 APOA1 CETP LCAT
24 phospholipid efflux GO:0033700 9.81 APOA1 APOA2 APOE
25 positive regulation of cholesterol esterification GO:0010873 9.8 APOA1 APOA2 APOE
26 chylomicron remnant clearance GO:0034382 9.8 APOB APOE LDLR
27 lipoprotein catabolic process GO:0042159 9.79 APOB APOE LDLR
28 positive regulation of lipid biosynthetic process GO:0046889 9.71 APOA1 APOE
29 regulation of protein metabolic process GO:0051246 9.71 APOE LDLR
30 regulation of cholesterol metabolic process GO:0090181 9.71 APOE LDLR
31 amyloid precursor protein metabolic process GO:0042982 9.71 APOE LDLRAP1
32 phospholipid homeostasis GO:0055091 9.7 APOA1 CETP
33 neuron projection regeneration GO:0031102 9.7 APOA1 APOE
34 regulation of cholesterol transport GO:0032374 9.7 APOA1 APOE
35 regulation of Cdc42 protein signal transduction GO:0032489 9.69 APOA1 APOE
36 peptidyl-methionine modification GO:0018206 9.69 APOA1 APOA2
37 cholesterol import GO:0070508 9.69 APOA1 LDLR
38 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 APOA1 APOA2
39 very-low-density lipoprotein particle clearance GO:0034447 9.68 APOB APOE
40 regulation of intestinal cholesterol absorption GO:0030300 9.68 APOA1 APOA2
41 negative regulation of lipase activity GO:0060192 9.67 APOA1 APOA2
42 protein oxidation GO:0018158 9.67 APOA1 APOA2
43 negative regulation of very-low-density lipoprotein particle remodeling GO:0010903 9.67 APOA1 APOA2
44 receptor-mediated endocytosis involved in cholesterol transport GO:0090118 9.66 LDLR LDLRAP1
45 positive regulation of low-density lipoprotein particle receptor catabolic process GO:0032805 9.65 APOE PCSK9
46 response to caloric restriction GO:0061771 9.65 APOE LDLR
47 lipoprotein metabolic process GO:0042157 9.56 APOA1 APOA2 APOB APOE APOL1 APOM
48 high-density lipoprotein particle remodeling GO:0034375 9.17 ALB APOA1 APOA2 APOE APOM CETP
49 post-translational protein modification GO:0043687 10.19 ALB APOA1 APOA2 APOB APOE APOL1
50 lipid metabolic process GO:0006629 10.18 APOA1 APOB APOE APOL1 CETP LCAT

Molecular functions related to Arcus Corneae according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.84 APOB APOE FN1 LPA
2 phospholipid binding GO:0005543 9.8 APOA1 APOA2 APOB APOE APOM
3 lipid binding GO:0008289 9.8 ALB APOA1 APOA2 APOB APOE APOL1
4 amyloid-beta binding GO:0001540 9.76 APOA1 APOE LDLR LDLRAP1
5 cholesterol binding GO:0015485 9.73 APOA1 APOA2 APOE CETP
6 antioxidant activity GO:0016209 9.67 ALB APOE APOM
7 phosphatidylcholine binding GO:0031210 9.65 APOA1 APOA2 CETP
8 low-density lipoprotein particle receptor binding GO:0050750 9.62 APOB APOE LDLRAP1 PCSK9
9 phospholipid transporter activity GO:0005548 9.6 APOA1 CETP
10 low-density lipoprotein particle binding GO:0030169 9.59 LDLR PCSK9
11 apolipoprotein binding GO:0034185 9.58 LPA PCSK9
12 high-density lipoprotein particle binding GO:0008035 9.58 APOA1 APOA2
13 lipoprotein particle binding GO:0071813 9.56 APOA1 APOE
14 lipase inhibitor activity GO:0055102 9.55 APOA1 APOA2
15 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.54 APOA1 APOA2 APOE
16 very-low-density lipoprotein particle receptor binding GO:0070326 9.52 APOE PCSK9
17 high-density lipoprotein particle receptor binding GO:0070653 9.51 APOA1 APOA2
18 cholesterol transporter activity GO:0017127 9.35 APOA1 APOA2 APOB APOE CETP
19 apolipoprotein receptor binding GO:0034190 9.33 APOA1 APOA2 PCSK9
20 lipid transporter activity GO:0005319 9.1 APOA1 APOA2 APOB APOE APOM CETP
21 protein binding GO:0005515 10.5 ALB APOA1 APOA2 APOB APOE APOL1
22 identical protein binding GO:0042802 10.08 ALB APOA1 APOE CRYAA FN1 LDLR

Sources for Arcus Corneae

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
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34 ICD10 via Orphanet
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