MCID: ARC023
MIFTS: 36

Arcus Corneae

Categories: Neuronal diseases

Aliases & Classifications for Arcus Corneae

MalaCards integrated aliases for Arcus Corneae:

Name: Arcus Corneae 57
Arcus Senilis 57 12 44 15 17 70
Corneal Arcus 57 12 54
Arcus of Cornea 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11342
OMIM® 57 107800
MeSH 44 D001112
SNOMED-CT 67 155159000
ICD10 32 H18.41
MedGen 41 C0003742
UMLS 70 C0003742

Summaries for Arcus Corneae

MalaCards based summary : Arcus Corneae, also known as arcus senilis, is related to hypertriglyceridemia, familial and arteriosclerosis. An important gene associated with Arcus Corneae is APOA1 (Apolipoprotein A1), and among its related pathways/superpathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. Affiliated tissues include eye, heart and kidney, and related phenotypes are Decreased free cholesterol and Decreased LDL uptake

Wikipedia : 73 Arcus senilis (AS), also known as gerontoxon, arcus lipoides, arcus cornae, coroneal arcus, arcus... more...

More information from OMIM: 107800

Related Diseases for Arcus Corneae

Diseases related to Arcus Corneae via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 hypertriglyceridemia, familial 30.1 APOB APOA1
2 arteriosclerosis 29.9 LPA APOB APOA1
3 lipid metabolism disorder 29.9 LPA LDLR LCAT APOB APOA1
4 cerebrovascular disease 29.8 LPA APOB APOA1
5 acute myocardial infarction 29.7 LPA APOB APOA1
6 xanthomatosis 29.7 LPA LDLRAP1 LDLR APOB
7 coronary heart disease 1 29.6 PCSK9 LPA LDLR LCAT APOB APOA1
8 peripheral vascular disease 29.6 LPA LCAT APOB APOA1
9 peripheral artery disease 29.6 PCSK9 LPA APOB APOA1
10 chronic kidney disease 29.6 LPA LCAT APOB APOA1
11 vascular disease 29.5 PCSK9 LPA LCAT APOB APOA1
12 lipoprotein quantitative trait locus 29.5 LPA LDLRAP1 LDLR LCAT APOB APOA1
13 atherosclerosis susceptibility 29.4 PCSK9 LPA LCAT APOB APOA1 ABCG5
14 myocardial infarction 29.3 PCSK9 LPA LCAT APOB APOA1
15 homozygous familial hypercholesterolemia 28.7 PCSK9 LDLRAP1 LDLR APOB APOA1 ABCG8
16 tangier disease 28.6 LPA LCAT APOB APOA1 ABCG8 ABCG5
17 familial hypercholesterolemia 27.9 PCSK9 LPA LDLRAP1 LDLR LCAT APOB
18 hypercholesterolemia, familial, 1 27.9 PCSK9 LPA LDLRAP1 LDLR LCAT APOB
19 hypercholesterolemia, familial, 3 11.5
20 cornea plana 2, autosomal recessive 11.2
21 apo a-i deficiency 10.2 LCAT APOA1
22 hypercholesterolemia, familial, 2 10.2 LDLR APOB
23 silent myocardial infarction 10.2 APOB APOA1
24 familial lcat deficiency 10.2 LCAT APOA1
25 leukodystrophy, hypomyelinating, 3 10.2 APOB APOA1
26 arteries, anomalies of 10.2
27 hypoalphalipoproteinemia 10.2 LCAT APOA1
28 familial lipoprotein lipase deficiency 10.2 APOB APOA1
29 parametritis 10.2 APOB APOA1
30 fish-eye disease 10.2 LCAT APOA1
31 familial apolipoprotein c-ii deficiency 10.2 APOB APOA1
32 cerebral atherosclerosis 10.2 APOB APOA1
33 hypobetalipoproteinemia, familial, 2 10.2 PCSK9 APOB
34 hyperlipoproteinemia, type v 10.2 APOB APOA1
35 cholesterol ester storage disease 10.1 LDLRAP1 LCAT
36 pediatric testicular germ cell tumor 10.1 LPA APOA1
37 corneal deposit 10.1 UBIAD1 LCAT
38 pinguecula 10.1
39 heart disease 10.1
40 myopia 10.1
41 fetal macrosomia 10.1 LCAT APOB APOA1
42 intermediate coronary syndrome 10.0 PCSK9 APOB APOA1
43 coronary stenosis 10.0 PCSK9 APOB APOA1
44 corneal dystrophy, meesmann, 1 10.0 UBIAD1 LCAT
45 inherited metabolic disorder 10.0 PCSK9 APOB APOA1
46 hyperlipoproteinemia, type iv 10.0 APOB APOA1 ABCG5
47 alcohol dependence 10.0
48 glaucoma, primary open angle 10.0
49 astigmatism 10.0
50 intraocular pressure quantitative trait locus 10.0

Graphical network of the top 20 diseases related to Arcus Corneae:



Diseases related to Arcus Corneae

Symptoms & Phenotypes for Arcus Corneae

Clinical features from OMIM®:

107800 (Updated 05-Apr-2021)

GenomeRNAi Phenotypes related to Arcus Corneae according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.96 ABCG8 LDLR
2 Decreased LDL uptake GR00340-A-1 8.32 LDLR

MGI Mouse Phenotypes related to Arcus Corneae:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.65 ABCG5 ABCG8 APOA1 APOB LCAT LDLR
2 liver/biliary system MP:0005370 9.17 ABCG5 ABCG8 APOA1 APOB LCAT LDLR

Drugs & Therapeutics for Arcus Corneae

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 BioHoFH - Biomarker for Homozygous Familial Hypercholesterolemia AN INTERNATIONAL, MULTICENTER, EPIDEMIOLOGICAL PROTOCOL Active, not recruiting NCT03198897

Search NIH Clinical Center for Arcus Corneae

Cochrane evidence based reviews: arcus senilis

Genetic Tests for Arcus Corneae

Anatomical Context for Arcus Corneae

MalaCards organs/tissues related to Arcus Corneae:

40
Eye, Heart, Kidney, Skin

Publications for Arcus Corneae

Articles related to Arcus Corneae:

(show top 50) (show all 109)
# Title Authors PMID Year
1
[Heredity of the arcus corneae]. 61 57
13792155 1959
2
Corneal arcus and its associations with ocular and general parameters: the Central India Eye and Medical Study. 57
22110074 2011
3
Corneal arcus, case finding and definition of individual clinical risk in heterozygous familial hypercholesterolaemia. 57
9894796 1998
4
Arcus not so senilis. 57
5713918 1968
5
A mutation in the human apolipoprotein A-I gene. Dominant effect on the level and characteristics of plasma high density lipoproteins. 61 54
1906882 1991
6
A Deep Learning Approach to Automatic Recognition of Arcus Senilis. 61
32802798 2020
7
FAMILIAL HYPERCHOLESTEROLAEMIA - A DIAGNOSIS THAT EVERY PLASTIC SURGEON CAN EXPERIENCE. 61
32370518 2020
8
An Evaluation of the Arcus Corneae For Age Estimation. 61
32110250 2019
9
Clinical and para-clinical description of a novel mutation for Schnyder dystrophy in a French family. 61
30446344 2018
10
Safety and reliability of femtosecond laser-assisted cataract surgery for Japanese eyes. 61
29264862 2018
11
A Myth Still Needs to be Clarified: A Case Report of the Frank's Sign. 61
29560293 2018
12
Alcohol consumption, smoking and development of visible age-related signs: a prospective cohort study. 61
29114032 2017
13
Descemet membrane detachment in femtosecond laser-assisted cataract surgery: a case report. 61
28915807 2017
14
Familial hypercholesterolemia: xanthelesma, arcus corneae and tendon xanthomas. 61
28340211 2017
15
Hypertension's 3 Dilemmas and 3 Solutions: Pharmacology of the Kidney in Hypertension. 61
28267687 2017
16
Corneal Biomechanical Properties in Patients With Arcus Senilis. 61
27124777 2016
17
Visible aging signs as risk markers for ischemic heart disease: Epidemiology, pathogenesis and clinical implications. 61
26590331 2016
18
Non-invasive measurement of transparency, arcus senilis, and scleral rim diameter of corneas during eye banking. 61
24306057 2014
19
Yellow corneal ring associated with vitamin supplementation for age-related macular degeneration. 61
22330962 2012
20
Cornea plana associated with open-angle glaucoma: a case report. 61
22160991 2011
21
Xanthelasmata, arcus corneae, and ischaemic vascular disease and death in general population: prospective cohort study. 61
21920887 2011
22
Mortality according to a prior assessment of biological age. 61
20021413 2009
23
Splenomegaly with sea-blue histiocytosis, dyslipidemia, and nephropathy in a patient with lecithin-cholesterol acyltransferase deficiency: a clinicopathologic correlation. 61
19592052 2009
24
Pseudogerontoxon. 61
15281982 2004
25
Keratoglobus and posterior subcapsular cataract: surgical considerations and in vivo microstructural analysis. 61
14967295 2004
26
[Correlation between the corneal arcus and dyslipoproteinemia]. 61
12858656 2003
27
Why do some people look older than they should? 61
11524516 2001
28
Rheumatic manifestations of hyperlipidaemia. 61
10985988 2000
29
Arcus senilis and mortality in a population with diabetes. 61
10844069 2000
30
[Clinical manifestations of familial hypercholesterolemia]. 61
10932620 2000
31
[Arcus senilis]. 61
10412362 1999
32
Longevity and gray hair, baldness, facial wrinkles, and arcus senilis in 13,000 men and women: the Copenhagen City Heart Study. 61
9754140 1998
33
Corneal arcus senilis and dyslipidemia. 61
9617096 1998
34
Autosomal recessive cornea plana. A clinical and genetic study of 78 cases in Finland. 61
9591953 1998
35
The relationship of cardiovascular risk factors measured at different ages to prediction of all-cause mortality and longevity. 61
18653129 1998
36
Schnyder corneal crystalline dystrophy: description of a new family with evidence of abnormal lipid storage in skin fibroblasts. 61
9450854 1998
37
Autosomal dominant cornea plana: clinical findings in a Cuban family and a review of the literature. 61
9228241 1997
38
Tissue utilization at the Minnesota Lions' Eye Bank. 61
8575175 1995
39
Rare and common mutations in hyperlipidemia and atherosclerosis. With special reference to familial defective apolipoprotein B-100. 61
7652481 1995
40
[Fish eye disease]. 61
7924949 1994
41
The assessment of biological age: a report from the Department of Environment Study. 61
7993926 1994
42
Apolipoprotein A-I and B distribution in the human cornea. 54
8258515 1993
43
Familial HDL deficiency due to marked hypercatabolism of normal apoA-I. 61
8364014 1993
44
[Arcus juvenilis and lecithin:cholesterol acyltransferase functions. Report of a case of familial fish-eye-disease]. 54
8221181 1993
45
Multivariate prediction of the first major cerebrovascular event in an Italian population sample of middle-aged men followed up for 25 years. 61
8418548 1993
46
[Correlation between Dupuytren's disease and arcus senilis: is dyslipidemia a common etiopathological factor?]. 61
1280972 1992
47
A phenocopy of type III dysbetalipoproteinemia occurring in a candidate family for a putative apo E receptor defect. 61
1648930 1991
48
[Corneal Ascher ring. A ring-shaped stromal corneal opacity]. 61
2056739 1991
49
[Ocular anomalies in Alagille's syndrome]. 61
1779119 1991
50
[Diagnostic and functional significance of arcus lipoides in hypercholesterolemia]. 61
2045021 1991

Variations for Arcus Corneae

Expression for Arcus Corneae

Search GEO for disease gene expression data for Arcus Corneae.

Pathways for Arcus Corneae

Pathways related to Arcus Corneae according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.61 UBIAD1 PCSK9 LPA LDLRAP1 LDLR LCAT
2
Show member pathways
12.34 UBIAD1 LDLR APOB APOA1
3
Show member pathways
12.14 PCSK9 LPA LDLRAP1 LDLR LCAT APOB
4
Show member pathways
12.04 LDLRAP1 LDLR APOB
5
Show member pathways
11.99 LDLR APOB APOA1
6
Show member pathways
11.95 UBIAD1 LDLR APOB APOA1
7 11.53 LDLR ABCG8 ABCG5
8
Show member pathways
11.35 PCSK9 LPA LDLRAP1 LDLR LCAT APOB
9 11.21 LPA APOB
10 11.15 ABCG8 ABCG5
11
Show member pathways
11.12 APOB APOA1 ABCG8 ABCG5
12 10.84 APOB APOA1
13
Show member pathways
10.15 PCSK9 LDLR

GO Terms for Arcus Corneae

Cellular components related to Arcus Corneae according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 9.67 LDLR ABCG8 ABCG5
2 clathrin-coated endocytic vesicle membrane GO:0030669 9.51 LDLR APOB
3 very-low-density lipoprotein particle GO:0034361 9.48 APOB APOA1
4 endocytic vesicle lumen GO:0071682 9.46 APOB APOA1
5 endolysosome membrane GO:0036020 9.43 PCSK9 LDLR
6 chylomicron GO:0042627 9.4 APOB APOA1
7 ATP-binding cassette (ABC) transporter complex GO:0043190 9.37 ABCG8 ABCG5
8 early endosome GO:0005769 9.35 PCSK9 LDLRAP1 LDLR APOB APOA1
9 high-density lipoprotein particle GO:0034364 9.33 LCAT APOB APOA1
10 intermediate-density lipoprotein particle GO:0034363 9.32 APOB APOA1
11 PCSK9-LDLR complex GO:1990666 9.26 PCSK9 LDLR
12 low-density lipoprotein particle GO:0034362 8.8 LDLR APOB APOA1

Biological processes related to Arcus Corneae according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 10 PCSK9 LPA LDLRAP1 LDLR LCAT APOB
2 receptor-mediated endocytosis GO:0006898 9.86 LDLRAP1 LDLR APOB APOA1
3 cellular protein metabolic process GO:0044267 9.85 PCSK9 APOB APOA1
4 membrane organization GO:0061024 9.82 LDLRAP1 LDLR APOB
5 intermembrane lipid transfer GO:0120009 9.8 APOB APOA1 ABCG8 ABCG5
6 lipid transport GO:0006869 9.8 LPA LDLR APOB APOA1 ABCG8 ABCG5
7 response to nutrient GO:0007584 9.79 APOA1 ABCG8 ABCG5
8 phospholipid metabolic process GO:0006644 9.77 PCSK9 LCAT APOA1
9 phospholipid transport GO:0015914 9.75 LDLR APOA1 ABCG8
10 cholesterol efflux GO:0033344 9.73 APOB APOA1 ABCG8 ABCG5
11 steroid metabolic process GO:0008202 9.73 PCSK9 LDLRAP1 LDLR LCAT APOB APOA1
12 triglyceride homeostasis GO:0070328 9.72 APOA1 ABCG8 ABCG5
13 lipoprotein metabolic process GO:0042157 9.71 PCSK9 LDLR APOB APOA1
14 intestinal cholesterol absorption GO:0030299 9.69 LDLR ABCG8 ABCG5
15 phosphatidylcholine biosynthetic process GO:0006656 9.68 LCAT APOA1
16 excretion GO:0007588 9.67 ABCG8 ABCG5
17 artery morphogenesis GO:0048844 9.67 LDLR APOB
18 response to muscle activity GO:0014850 9.67 ABCG8 ABCG5
19 low-density lipoprotein particle clearance GO:0034383 9.67 PCSK9 LDLRAP1 LDLR APOB
20 sterol transport GO:0015918 9.66 ABCG8 ABCG5
21 phosphatidylcholine metabolic process GO:0046470 9.66 LCAT APOA1
22 reverse cholesterol transport GO:0043691 9.65 LCAT APOA1
23 high-density lipoprotein particle remodeling GO:0034375 9.65 LCAT APOA1
24 lipoprotein biosynthetic process GO:0042158 9.65 LCAT APOB APOA1
25 low-density lipoprotein particle remodeling GO:0034374 9.64 LPA APOB
26 bile acid signaling pathway GO:0038183 9.64 ABCG8 ABCG5
27 chylomicron assembly GO:0034378 9.63 APOB APOA1
28 high-density lipoprotein particle clearance GO:0034384 9.63 LDLR APOA1
29 cholesterol metabolic process GO:0008203 9.63 PCSK9 LDLRAP1 LDLR LCAT APOB APOA1
30 very-low-density lipoprotein particle remodeling GO:0034372 9.62 LCAT APOA1
31 chylomicron remodeling GO:0034371 9.62 APOB APOA1
32 chylomicron remnant clearance GO:0034382 9.61 LDLR APOB
33 cholesterol import GO:0070508 9.59 LDLR APOA1
34 lipoprotein catabolic process GO:0042159 9.58 LDLR APOB
35 receptor-mediated endocytosis involved in cholesterol transport GO:0090118 9.57 LDLRAP1 LDLR
36 negative regulation of intestinal cholesterol absorption GO:0045796 9.54 ABCG8 ABCG5
37 negative regulation of intestinal phytosterol absorption GO:0010949 9.52 ABCG8 ABCG5
38 cholesterol transport GO:0030301 9.35 LDLRAP1 LDLR LCAT APOB APOA1
39 cholesterol homeostasis GO:0042632 9.23 PCSK9 LDLRAP1 LDLR LCAT APOB APOA1

Molecular functions related to Arcus Corneae according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amyloid-beta binding GO:0001540 9.43 LDLRAP1 LDLR APOA1
2 lipid transporter activity GO:0005319 9.4 APOB APOA1
3 apolipoprotein binding GO:0034185 9.37 PCSK9 LPA
4 low-density lipoprotein particle binding GO:0030169 9.32 PCSK9 LDLR
5 apolipoprotein receptor binding GO:0034190 9.16 PCSK9 APOA1
6 low-density lipoprotein particle receptor binding GO:0050750 9.13 PCSK9 LDLRAP1 APOB
7 intermembrane cholesterol transfer activity GO:0120020 8.92 APOB APOA1 ABCG8 ABCG5

Sources for Arcus Corneae

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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