Aliases & Classifications for Arcus Corneae

MalaCards integrated aliases for Arcus Corneae:

Name: Arcus Corneae 58
Arcus Senilis 58 12 45 15 17 74
Corneal Arcus 58 12 56
Arcus of Cornea 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11342
OMIM 58 107800
MeSH 45 D001112
ICD10 34 H18.41
MedGen 43 C0003742
UMLS 74 C0003742

Summaries for Arcus Corneae

MalaCards based summary : Arcus Corneae, also known as arcus senilis, is related to coronary artery anomaly and arteriosclerosis. An important gene associated with Arcus Corneae is APOA1 (Apolipoprotein A1), and among its related pathways/superpathways are Metabolism and Vesicle-mediated transport. The drugs Riboflavin and Vitamin B2 have been mentioned in the context of this disorder. Affiliated tissues include heart, eye and kidney, and related phenotypes are Decreased free cholesterol and Increased LDL uptake

Wikipedia : 77 Arcus senilis is an old age syndrome where there is a white, grey, or blue opaque ring in the corneal... more...

Description from OMIM: 107800

Related Diseases for Arcus Corneae

Diseases related to Arcus Corneae via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 coronary artery anomaly 30.3 APOA1 APOB CETP COG2 LPA
2 arteriosclerosis 30.1 APOA1 APOB APOE COG2 LPA
3 heart disease 30.0 ALB APOA1 APOB APOE LDLR
4 homozygous familial hypercholesterolemia 29.8 APOB APOE LDLR LDLRAP1 PCSK9
5 arteries, anomalies of 29.1 ALB APOA1 APOB APOE CETP COG2
6 coronary heart disease 1 29.0 APOA1 APOA2 APOB APOE CETP COG2
7 vascular disease 28.8 ALB APOA1 APOB APOE CETP LDLR
8 myocardial infarction 28.3 ALB APOA1 APOA2 APOB APOE CETP
9 hypercholesterolemia, familial 28.3 APOA1 APOA2 APOB APOE CETP COG2
10 cornea plana 2, autosomal recessive 11.4
11 apo a-i deficiency 10.4 APOA1 LCAT
12 fish-eye disease 10.3 APOA1 APOA2 LCAT
13 lysosomal and lipase deficiency 10.3 APOB LDLRAP1
14 wrinkles 10.2
15 pinguecula 10.2
16 myopia 10.2
17 hypobetalipoproteinemia, familial, 1 10.2 APOB COG2 PCSK9
18 amyloidosis aa 10.2 APOA1 LCAT LPA
19 hereditary amyloidosis 10.2 APOA1 APOA2
20 cholesterol ester storage disease 10.2 APOB COG2 LDLRAP1
21 niemann-pick disease, type b 10.2 APOA1 LCAT LPA
22 xanthoma disseminatum 10.2 APOB APOE
23 hyperlipoproteinemia, type iv 10.2 APOA2 APOB
24 dysbaric osteonecrosis 10.1 APOA1 APOB
25 amyloidosis, familial visceral 10.1 APOA1 APOA2 LPA
26 inherited metabolic disorder 10.1 APOA1 APOB COG2 PCSK9
27 hepatic lipase deficiency 10.1 APOA1 APOE
28 hypercholesterolemia, autosomal recessive 10.1 LDLR LDLRAP1 PCSK9
29 cerebral atherosclerosis 10.1 APOA1 APOE
30 hyperlipoproteinemia, type v 10.1 APOA1 APOB APOE
31 ischemic heart disease 10.1 APOA1 APOB APOE
32 fetal macrosomia 10.1 APOA1 APOB APOM LCAT
33 glaucoma, primary open angle 10.1
34 acute myocardial infarction 10.1
35 open-angle glaucoma 10.1
36 carotid stenosis 10.1
37 hypercholesterolemia, autosomal dominant, type b 10.1 APOB APOE LDLR
38 kwashiorkor 10.0 ALB LCAT
39 prediabetes syndrome 10.0 ALB APOB COG2
40 schnyder corneal dystrophy 10.0 APOA2 APOB APOE UBIAD1
41 hyperlipidemia, familial combined 10.0 APOA1 APOA2 APOB COG2 LPA
42 glucose metabolism disease 10.0 ALB APOB COG2
43 acquired metabolic disease 9.9 ALB APOA1 APOB COG2
44 cerebrovascular disease 9.9 APOA1 APOB APOE LDLR
45 peripheral vascular disease 9.9 ALB APOA1 APOB LPA
46 hypertriglyceridemia, familial 9.8 APOA1 APOB APOE CETP
47 defective apolipoprotein b-100 9.8 APOB APOE LCAT LDLR PCSK9
48 stroke, ischemic 9.8 APOB APOE COG2 LPA
49 gallbladder disease 9.8 APOA1 APOB APOE CETP
50 sea-blue histiocyte disease 9.8 APOB APOE LCAT LDLR PCSK9

Graphical network of the top 20 diseases related to Arcus Corneae:



Diseases related to Arcus Corneae

Symptoms & Phenotypes for Arcus Corneae

Clinical features from OMIM:

107800

GenomeRNAi Phenotypes related to Arcus Corneae according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.56 APOA1 APOB APOE CETP LDLR LDLRAP1
2 Increased LDL uptake GR00340-A-1 8.8 APOA1 APOE LDLR

MGI Mouse Phenotypes related to Arcus Corneae:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 ALB APOA1 APOA2 APOB APOE APOM
2 liver/biliary system MP:0005370 9.23 ALB APOA1 APOB APOE FOXM1 LCAT

Drugs & Therapeutics for Arcus Corneae

Drugs for Arcus Corneae (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Not Applicable 83-88-5 493570
2 Vitamin B2 Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Biomarker for Homozygous Familial Hypercholesterolemia (BioHoFH) Recruiting NCT03198897
2 PiXL for Correction of Hyperopia Enrolling by invitation NCT03805425 Not Applicable

Search NIH Clinical Center for Arcus Corneae

Cochrane evidence based reviews: arcus senilis

Genetic Tests for Arcus Corneae

Anatomical Context for Arcus Corneae

MalaCards organs/tissues related to Arcus Corneae:

42
Heart, Eye, Kidney

Publications for Arcus Corneae

Articles related to Arcus Corneae:

(show all 37)
# Title Authors Year
1
Familial hypercholesterolemia: xanthelesma, arcus corneae and tendon xanthomas. ( 28340211 )
2017
2
Corneal Biomechanical Properties in Patients With Arcus Senilis. ( 27124777 )
2016
3
Non-invasive measurement of transparency, arcus senilis, and scleral rim diameter of corneas during eye banking. ( 24306057 )
2014
4
Xanthelasmata, arcus corneae, and ischaemic vascular disease and death in general population: prospective cohort study. ( 21920887 )
2011
5
Arcus senilis and mortality in a population with diabetes. ( 10844069 )
2000
6
Longevity and gray hair, baldness, facial wrinkles, and arcus senilis in 13,000 men and women: the Copenhagen City Heart Study. ( 9754140 )
1998
7
Corneal arcus senilis and dyslipidemia. ( 9617096 )
1998
8
The prevalence of corneal arcus senilis in known insulin-dependent diabetic patients. ( 4020009 )
1985
9
Arcus senilis: an important forensic physical finding. ( 7114015 )
1982
10
Significance of arcus senilis in Caucasians. ( 7205858 )
1981
11
Arcus senilis and alcohol intake. ( 70669 )
1977
12
Unilateral arcus corneae senilis and carotid occlusive disease. ( 1173857 )
1975
13
Letter: Arcus senilis and atherosclerosis in blacks. ( 1110679 )
1975
14
Letter: Arcus senilis and carotid disease. ( 1242181 )
1975
15
Arcus senilis. ( 4122363 )
1973
16
The cornea at northern latitudes--corneal power, arcus senilis and corneal scars in Eskimos, Lapps and Finns. ( 4707215 )
1973
17
Unilateral arcus senilis. ( 4711354 )
1973
18
Alcohol consumption and arcus senilis: a search for a significant relationship. ( 4507258 )
1972
19
The age-prevalence of arcus senilis, greying of hair, and baldness. Etiological considerations. ( 5092816 )
1971
20
Arcus senilis: its relation to certain attributes and risk factors in patients with coronary heart disease. ( 5433305 )
1970
21
Arcus senilis corneae--its relationship to serum lipids in the South African Bantu. ( 5822930 )
1969
22
Arcus senilis and adulthood myopia. ( 6022253 )
1967
23
Significance of arcus senilis under anesthesia. ( 5177119 )
1966
24
Lipid analysis of the human cornea with and without arcus senilis. ( 5946113 )
1966
25
A note on blood serum cholesterol levels and arcus senilis. ( 5213294 )
1965
26
Arcus senilis and coronary artery disease. ( 5842529 )
1965
27
ARCUS SENILIS IN MIDDLE-AGED MEN. ( 14237926 )
1965
28
THE INCIDENCE OF ARCUS SENILIS IN ISCHAEMIC HEART-DISEASE ITS RELATION TO SERUM-LIPID LEVELS. ( 14247887 )
1965
29
Arcus senilis and arteriosclerosis in the aged. ( 13974685 )
1963
30
Pterygium and its relation to arcus senilis, pinguecula and other similar conditions. ( 13958798 )
1962
31
The lipids of arcus senilis. ( 13861495 )
1962
32
Association of specific overt behavior pattern with blood and cardiovascular findings; blood cholesterol level, blood clotting time, incidence of arcus senilis, and clinical coronary artery disease. ( 13630753 )
1959
33
Arcus senilis; its pathology and histochemistry. ( 13636543 )
1959
34
Sensitivity of the cornea in arcus senilis. ( 13532613 )
1958
35
Arcus senilis corneae: its frequency in some ethnic groups. ( 13301643 )
1955
36
Arcus senilis corneae; its clinical development and relationship to serum lipids, proteins and lipoproteins. ( 13227974 )
1954
37
Arcus senilis and serum cholesterol levels in the Aleut. ( 15406082 )
1950

Variations for Arcus Corneae

Expression for Arcus Corneae

Search GEO for disease gene expression data for Arcus Corneae.

Pathways for Arcus Corneae

Pathways related to Arcus Corneae according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 ALB APOA1 APOA2 APOB APOE APOM
2
Show member pathways
13.16 ALB APOA1 APOB APOE APOL1 COG2
3
Show member pathways
12.41 APOA1 APOA2 APOB APOE APOM LDLR
4
Show member pathways
12.23 ALB APOA1 APOA2 APOB APOE CETP
5
Show member pathways
12.14 ALB APOA1 APOB APOE LDLR
6
Show member pathways
12.03 APOA1 APOA2 APOB APOE APOM LDLR
7 11.88 ALB APOA1 APOE APOM
8
Show member pathways
11.74 ALB APOA1 APOB APOE APOL1
9
Show member pathways
11.39 APOA1 APOA2 APOB APOE CETP LCAT
10 10.89 APOA1 APOA2 APOL1
11 10.87 APOA1 APOB

GO Terms for Arcus Corneae

Cellular components related to Arcus Corneae according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.91 ALB APOA1 APOA2 APOB APOE APOL1
2 blood microparticle GO:0072562 9.89 ALB APOA1 APOA2 APOE APOL1
3 early endosome GO:0005769 9.87 APOA1 APOA2 APOB APOE LDLR LDLRAP1
4 clathrin-coated endocytic vesicle membrane GO:0030669 9.72 APOB APOE LDLR
5 endocytic vesicle lumen GO:0071682 9.7 APOA1 APOB APOE
6 spherical high-density lipoprotein particle GO:0034366 9.65 APOA1 APOA2 APOM
7 intermediate-density lipoprotein particle GO:0034363 9.63 APOA1 APOB APOE
8 discoidal high-density lipoprotein particle GO:0034365 9.58 APOA1 APOE APOM
9 endolysosome membrane GO:0036020 9.57 LDLR PCSK9
10 chylomicron GO:0042627 9.56 APOA1 APOA2 APOB APOE
11 low-density lipoprotein particle GO:0034362 9.55 APOA1 APOB APOE APOM LDLR
12 PCSK9-LDLR complex GO:1990666 9.54 LDLR PCSK9
13 very-low-density lipoprotein particle GO:0034361 9.43 APOA1 APOA2 APOB APOE APOL1 APOM
14 high-density lipoprotein particle GO:0034364 9.17 APOA1 APOA2 APOE APOL1 APOM CETP
15 extracellular space GO:0005615 10.21 ALB APOA1 APOA2 APOB APOE APOL1
16 extracellular region GO:0005576 10.21 ALB APOA1 APOA2 APOB APOE APOL1
17 Golgi apparatus GO:0005794 10.1 ALB APOE COG2 LDLR PCSK9 SLC29A3

Biological processes related to Arcus Corneae according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 retinoid metabolic process GO:0001523 9.99 APOA1 APOA2 APOB APOE APOM
2 cellular oxidant detoxification GO:0098869 9.94 ALB APOE APOM UBIAD1
3 triglyceride metabolic process GO:0006641 9.92 APOA2 APOE CETP PCSK9
4 low-density lipoprotein particle clearance GO:0034383 9.91 APOB LDLR LDLRAP1 PCSK9
5 cholesterol efflux GO:0033344 9.91 APOA1 APOA2 APOB APOE APOM
6 reverse cholesterol transport GO:0043691 9.91 APOA1 APOA2 APOE APOM CETP LCAT
7 steroid metabolic process GO:0008202 9.91 APOA1 APOB APOE APOL1 CETP LCAT
8 membrane organization GO:0061024 9.89 APOB LDLR LDLRAP1
9 high-density lipoprotein particle assembly GO:0034380 9.88 APOA1 APOA2 APOE APOM
10 low-density lipoprotein particle remodeling GO:0034374 9.88 APOA2 APOB APOE CETP LPA
11 phospholipid metabolic process GO:0006644 9.87 APOA1 LCAT PCSK9
12 chylomicron assembly GO:0034378 9.87 APOA1 APOA2 APOB APOE
13 phospholipid transport GO:0015914 9.85 APOA1 CETP LDLR
14 very-low-density lipoprotein particle remodeling GO:0034372 9.85 APOA1 APOE CETP LCAT
15 high-density lipoprotein particle clearance GO:0034384 9.85 APOA1 APOA2 APOE APOM LDLR
16 chylomicron remodeling GO:0034371 9.84 APOA1 APOA2 APOB APOE
17 triglyceride homeostasis GO:0070328 9.83 APOA1 APOE CETP
18 phosphatidylcholine biosynthetic process GO:0006656 9.83 APOA1 APOA2 LCAT
19 lipoprotein biosynthetic process GO:0042158 9.83 APOA1 APOB APOE LCAT
20 triglyceride catabolic process GO:0019433 9.82 APOA1 APOB APOE
21 phospholipid efflux GO:0033700 9.81 APOA1 APOA2 APOE
22 positive regulation of cholesterol esterification GO:0010873 9.8 APOA1 APOA2 APOE
23 chylomicron remnant clearance GO:0034382 9.8 APOB APOE LDLR
24 lipoprotein catabolic process GO:0042159 9.77 APOB APOE LDLR
25 lipoprotein metabolic process GO:0042157 9.76 APOA1 APOA2 APOB APOE APOL1 APOM
26 artery morphogenesis GO:0048844 9.72 APOB APOE
27 positive regulation of lipid biosynthetic process GO:0046889 9.71 APOA1 APOE
28 regulation of cholesterol metabolic process GO:0090181 9.71 APOE LDLR
29 phosphatidylcholine metabolic process GO:0046470 9.71 CETP LCAT
30 regulation of protein metabolic process GO:0051246 9.71 APOE LDLR
31 amyloid precursor protein metabolic process GO:0042982 9.7 APOE LDLRAP1
32 phospholipid homeostasis GO:0055091 9.7 APOA1 CETP
33 regulation of Cdc42 protein signal transduction GO:0032489 9.7 APOA1 APOE
34 regulation of cholesterol transport GO:0032374 9.69 APOA1 APOE
35 cholesterol import GO:0070508 9.69 APOA1 LDLR
36 negative regulation of cytokine secretion involved in immune response GO:0002740 9.69 APOA1 APOA2
37 peptidyl-methionine modification GO:0018206 9.68 APOA1 APOA2
38 very-low-density lipoprotein particle clearance GO:0034447 9.68 APOB APOE
39 regulation of intestinal cholesterol absorption GO:0030300 9.68 APOA1 APOA2
40 negative regulation of lipase activity GO:0060192 9.67 APOA1 APOA2
41 protein oxidation GO:0018158 9.67 APOA1 APOA2
42 negative regulation of very-low-density lipoprotein particle remodeling GO:0010903 9.67 APOA1 APOA2
43 receptor-mediated endocytosis involved in cholesterol transport GO:0090118 9.66 LDLR LDLRAP1
44 positive regulation of low-density lipoprotein particle receptor catabolic process GO:0032805 9.65 APOE PCSK9
45 response to caloric restriction GO:0061771 9.65 APOE LDLR
46 cholesterol transport GO:0030301 9.5 APOA1 APOA2 APOB CETP LCAT LDLR
47 positive regulation of endocytosis GO:0045807 9.42 APOE
48 high-density lipoprotein particle remodeling GO:0034375 9.17 ALB APOA1 APOA2 APOE APOM CETP
49 lipid metabolic process GO:0006629 10.19 APOA1 APOB APOE APOL1 CETP LCAT
50 post-translational protein modification GO:0043687 10.15 ALB APOA1 APOA2 APOB APOE APOL1

Molecular functions related to Arcus Corneae according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 phospholipid binding GO:0005543 9.83 APOA1 APOA2 APOB APOE APOM
2 amyloid-beta binding GO:0001540 9.78 APOA1 APOE LDLR LDLRAP1
3 cholesterol binding GO:0015485 9.76 APOA1 APOA2 APOE CETP
4 antioxidant activity GO:0016209 9.67 ALB APOE APOM UBIAD1
5 lipid binding GO:0008289 9.63 ALB APOA1 APOA2 APOE APOL1 CETP
6 low-density lipoprotein particle receptor binding GO:0050750 9.62 APOB APOE LDLRAP1 PCSK9
7 phospholipid transporter activity GO:0005548 9.58 APOA1 CETP
8 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.58 APOA1 APOA2 APOE
9 apolipoprotein binding GO:0034185 9.57 LPA PCSK9
10 low-density lipoprotein particle binding GO:0030169 9.56 LDLR PCSK9
11 high-density lipoprotein particle binding GO:0008035 9.55 APOA1 APOA2
12 lipase inhibitor activity GO:0055102 9.54 APOA1 APOA2
13 lipoprotein particle binding GO:0071813 9.52 APOA1 APOE
14 very-low-density lipoprotein particle receptor binding GO:0070326 9.51 APOE PCSK9
15 high-density lipoprotein particle receptor binding GO:0070653 9.49 APOA1 APOA2
16 apolipoprotein receptor binding GO:0034190 9.43 APOA1 APOA2 PCSK9
17 cholesterol transporter activity GO:0017127 9.35 APOA1 APOA2 APOB APOE CETP
18 lipid transporter activity GO:0005319 9.1 APOA1 APOA2 APOB APOE APOM CETP
19 protein binding GO:0005515 10.45 ALB APOA1 APOA2 APOB APOE APOL1

Sources for Arcus Corneae

3 CDC
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9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
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50 NCI
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59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
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