MCID: ARC023
MIFTS: 43

Arcus Corneae

Categories: Eye diseases

Aliases & Classifications for Arcus Corneae

MalaCards integrated aliases for Arcus Corneae:

Name: Arcus Corneae 57
Arcus Senilis 57 12 44 15 73
Corneal Arcus 57 12 55
Arcus of Cornea 12

Classifications:



External Ids:

OMIM 57 107800
Disease Ontology 12 DOID:11342
ICD10 33 H18.41
MeSH 44 D001112
MedGen 42 C0003742
UMLS 73 C0003742

Summaries for Arcus Corneae

MalaCards based summary : Arcus Corneae, also known as arcus senilis, is related to coronary artery anomaly and heart disease. An important gene associated with Arcus Corneae is LCAT (Lecithin-Cholesterol Acyltransferase), and among its related pathways/superpathways are Metabolism and Vesicle-mediated transport. Affiliated tissues include heart, eye and kidney, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Arcus senilis is an old age syndrome where there is a white, grey, or blue opaque ring in the corneal... more...

Description from OMIM: 107800

Related Diseases for Arcus Corneae

Diseases related to Arcus Corneae via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 coronary artery anomaly 30.4 LPA COG2 CETP APOB APOA1
2 heart disease 30.2 LDLR APOE APOB APOA1 ALB
3 arteriosclerosis 30.2 LPA COG2 APOE APOB APOA1
4 homozygous familial hypercholesterolemia 29.9 PCSK9 LDLRAP1 LDLR APOE APOB
5 arteries, anomalies of 29.7 LPA LDLR COG2 CETP APOE APOB
6 coronary heart disease 1 29.5 LPA LDLR LCAT COG2 CETP APOE
7 vascular disease 29.4 LPA LDLR CETP APOE APOB APOA1
8 hypercholesterolemia, familial 29.1 PCSK9 LPA LDLRAP1 LDLR LCAT COG2
9 cornea plana 2, autosomal recessive 11.4
10 apo a-i deficiency 10.3 LCAT APOA1
11 wrinkles 10.2
12 pinguecula 10.2
13 myopia 10.2
14 fish-eye disease 10.2 LCAT APOA2 APOA1
15 hypobetalipoproteinemia, familial, 1 10.2 PCSK9 COG2 APOB
16 lysosomal and lipase deficiency 10.2 LDLRAP1 APOB
17 cholesterol ester storage disease 10.2 LDLRAP1 COG2 APOB
18 amyloidosis aa 10.2 LPA LCAT APOA1
19 niemann-pick disease, type b 10.2 LPA LCAT APOA1
20 hypercholesterolemia, autosomal recessive 10.1 PCSK9 LDLRAP1 LDLR
21 xanthoma disseminatum 10.1 APOE APOB
22 inherited metabolic disorder 10.1 PCSK9 COG2 APOB APOA1
23 amyloidosis, familial visceral 10.1 LPA APOA2 APOA1
24 fetal macrosomia 10.1 LCAT APOM APOB APOA1
25 hereditary amyloidosis 10.1 APOA2 APOA1
26 hyperlipoproteinemia, type v 10.1 APOE APOB APOA1
27 ischemic heart disease 10.1 APOE APOB APOA1
28 hypercholesterolemia, autosomal dominant, type b 10.1 LDLR APOE APOB
29 cerebral atherosclerosis 10.1 APOE APOA1
30 hepatic lipase deficiency 10.0 APOE APOA1
31 glaucoma, primary open angle 10.0
32 open-angle glaucoma 10.0
33 hyperlipidemia, familial combined 10.0 LPA COG2 APOB APOA2 APOA1
34 prediabetes syndrome 10.0 COG2 APOB ALB
35 kwashiorkor 10.0 LCAT ALB
36 schnyder corneal dystrophy 10.0 UBIAD1 APOE APOB APOA2
37 glucose metabolism disease 10.0 COG2 APOB ALB
38 cerebrovascular disease 10.0 LDLR APOE APOB APOA1
39 acquired metabolic disease 10.0 COG2 APOB APOA1 ALB
40 defective apolipoprotein b-100 9.9 PCSK9 LDLR LCAT APOE APOB
41 peripheral vascular disease 9.9 LPA APOB APOA1 ALB
42 sea-blue histiocyte disease 9.9 PCSK9 LDLR LCAT APOE APOB
43 stroke, ischemic 9.9 LPA COG2 APOE APOB
44 leukodystrophy, hypomyelinating, 3 9.9 LPA APOE APOB APOA2 APOA1
45 carotid artery disease 9.9 LPA COG2 APOE APOB APOA1
46 end stage renal failure 9.9 FN1 APOB ALB
47 hypertriglyceridemia, familial 9.9 CETP APOE APOB APOA1
48 gallbladder disease 9.9 CETP APOE APOB APOA1
49 xanthomatosis 9.9 LPA LDLRAP1 LDLR APOE APOB
50 diabetes mellitus, insulin-dependent 9.9 LPA APOB APOA1 ALB

Graphical network of the top 20 diseases related to Arcus Corneae:



Diseases related to Arcus Corneae

Symptoms & Phenotypes for Arcus Corneae

Clinical features from OMIM:

107800

GenomeRNAi Phenotypes related to Arcus Corneae according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 10.18 FOXM1
2 Decreased viability GR00402-S-2 10.18 ALB APOA1 APOA2 APOB APOE APOL1
3 Decreased free cholesterol GR00340-A-2 9.86 APOA1 APOB APOE CETP LDLR LDLRAP1
4 no effect GR00402-S-1 9.62 ALB APOA1 APOA2 APOB APOE APOL1
5 Increased LDL uptake GR00340-A-1 9.13 APOA1 APOE LDLR

MGI Mouse Phenotypes related to Arcus Corneae:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.83 ALB APOA1 APOA2 APOB APOE APOM
2 liver/biliary system MP:0005370 9.28 ALB APOA1 APOB APOE FN1 FOXM1

Drugs & Therapeutics for Arcus Corneae

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Biomarker for Homozygous Familial Hypercholesterolemia Recruiting NCT03198897
2 PiXL for Correction of Hyperopia Enrolling by invitation NCT03805425 Not Applicable

Search NIH Clinical Center for Arcus Corneae

Cochrane evidence based reviews: arcus senilis

Genetic Tests for Arcus Corneae

Anatomical Context for Arcus Corneae

MalaCards organs/tissues related to Arcus Corneae:

41
Heart, Eye, Kidney

Publications for Arcus Corneae

Articles related to Arcus Corneae:

(show all 37)
# Title Authors Year
1
Familial hypercholesterolemia: xanthelesma, arcus corneae and tendon xanthomas. ( 28340211 )
2017
2
Corneal Biomechanical Properties in Patients With Arcus Senilis. ( 27124777 )
2016
3
Non-invasive measurement of transparency, arcus senilis, and scleral rim diameter of corneas during eye banking. ( 24306057 )
2013
4
Xanthelasmata, arcus corneae, and ischaemic vascular disease and death in general population: prospective cohort study. ( 21920887 )
2011
5
Arcus senilis and mortality in a population with diabetes. ( 10844069 )
2000
6
Longevity and gray hair, baldness, facial wrinkles, and arcus senilis in 13,000 men and women: the Copenhagen City Heart Study. ( 9754140 )
1998
7
Corneal arcus senilis and dyslipidemia. ( 9617096 )
1998
8
The prevalence of corneal arcus senilis in known insulin-dependent diabetic patients. ( 4020009 )
1985
9
Arcus senilis: an important forensic physical finding. ( 7114015 )
1982
10
Significance of arcus senilis in Caucasians. ( 7205858 )
1981
11
Arcus senilis and alcohol intake. ( 70669 )
1977
12
Letter: Arcus senilis and atherosclerosis in blacks. ( 1110679 )
1975
13
Letter: Arcus senilis and carotid disease. ( 1242181 )
1975
14
Unilateral arcus corneae senilis and carotid occlusive disease. ( 1173857 )
1975
15
Unilateral arcus senilis. ( 4711354 )
1973
16
The cornea at northern latitudes--corneal power, arcus senilis and corneal scars in Eskimos, Lapps and Finns. ( 4707215 )
1973
17
Arcus senilis. ( 4122363 )
1973
18
Alcohol consumption and arcus senilis: a search for a significant relationship. ( 4507258 )
1972
19
The age-prevalence of arcus senilis, greying of hair, and baldness. Etiological considerations. ( 5092816 )
1971
20
Arcus senilis: its relation to certain attributes and risk factors in patients with coronary heart disease. ( 5433305 )
1970
21
Arcus senilis corneae--its relationship to serum lipids in the South African Bantu. ( 5822930 )
1969
22
Arcus senilis and adulthood myopia. ( 6022253 )
1967
23
Significance of arcus senilis under anesthesia. ( 5177119 )
1966
24
Lipid analysis of the human cornea with and without arcus senilis. ( 5946113 )
1966
25
ARCUS SENILIS IN MIDDLE-AGED MEN. ( 14237926 )
1965
26
Arcus senilis and coronary artery disease. ( 5842529 )
1965
27
THE INCIDENCE OF ARCUS SENILIS IN ISCHAEMIC HEART-DISEASE ITS RELATION TO SERUM-LIPID LEVELS. ( 14247887 )
1965
28
A note on blood serum cholesterol levels and arcus senilis. ( 5213294 )
1965
29
Arcus senilis and arteriosclerosis in the aged. ( 13974685 )
1963
30
Pterygium and its relation to arcus senilis, pinguecula and other similar conditions. ( 13958798 )
1962
31
The lipids of arcus senilis. ( 13861495 )
1962
32
Association of specific overt behavior pattern with blood and cardiovascular findings; blood cholesterol level, blood clotting time, incidence of arcus senilis, and clinical coronary artery disease. ( 13630753 )
1959
33
Arcus senilis; its pathology and histochemistry. ( 13636543 )
1959
34
Sensitivity of the cornea in arcus senilis. ( 13532613 )
1958
35
Arcus senilis corneae: its frequency in some ethnic groups. ( 13301643 )
1955
36
Arcus senilis corneae; its clinical development and relationship to serum lipids, proteins and lipoproteins. ( 13227974 )
1954
37
Arcus senilis and serum cholesterol levels in the Aleut. ( 15406082 )
1950

Variations for Arcus Corneae

Expression for Arcus Corneae

Search GEO for disease gene expression data for Arcus Corneae.

Pathways for Arcus Corneae

Pathways related to Arcus Corneae according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 ALB APOA1 APOA2 APOB APOE APOM
2
Show member pathways
13.16 ALB APOA1 APOB APOE APOL1 COG2
3
Show member pathways
12.41 APOA1 APOA2 APOB APOE APOM LDLR
4
Show member pathways
12.23 ALB APOA1 APOA2 APOB APOE CETP
5
Show member pathways
12.14 ALB APOA1 APOB APOE LDLR
6
Show member pathways
12.03 APOA1 APOA2 APOB APOE APOM LDLR
7 11.88 ALB APOA1 APOE APOM
8
Show member pathways
11.74 ALB APOA1 APOB APOE APOL1
9
Show member pathways
11.39 APOA1 APOA2 APOB APOE CETP LCAT
10 11.35 APOB FN1 LPA
11 10.82 APOA1 APOA2 APOL1
12
Show member pathways
10.29 LDLR PCSK9

GO Terms for Arcus Corneae

Cellular components related to Arcus Corneae according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 early endosome GO:0005769 9.91 APOA1 APOA2 APOB APOE LDLR LDLRAP1
2 blood microparticle GO:0072562 9.88 ALB APOA1 APOA2 APOE APOL1 FN1
3 endoplasmic reticulum lumen GO:0005788 9.86 ALB APOA1 APOA2 APOB APOE APOL1
4 clathrin-coated endocytic vesicle membrane GO:0030669 9.72 APOB APOE LDLR
5 endocytic vesicle lumen GO:0071682 9.7 APOA1 APOB APOE
6 spherical high-density lipoprotein particle GO:0034366 9.69 APOA1 APOA2 APOM
7 intermediate-density lipoprotein particle GO:0034363 9.65 APOA1 APOB APOE
8 discoidal high-density lipoprotein particle GO:0034365 9.63 APOA1 APOE APOM
9 chylomicron GO:0042627 9.62 APOA1 APOA2 APOB APOE
10 endolysosome membrane GO:0036020 9.57 LDLR PCSK9
11 low-density lipoprotein particle GO:0034362 9.55 APOA1 APOB APOE APOM LDLR
12 PCSK9-LDLR complex GO:1990666 9.54 LDLR PCSK9
13 very-low-density lipoprotein particle GO:0034361 9.43 APOA1 APOA2 APOB APOE APOL1 APOM
14 high-density lipoprotein particle GO:0034364 9.17 APOA1 APOA2 APOE APOL1 APOM CETP
15 extracellular region GO:0005576 10.25 ALB APOA1 APOA2 APOB APOE APOL1
16 extracellular space GO:0005615 10.24 ALB APOA1 APOA2 APOB APOE APOL1
17 extracellular exosome GO:0070062 10.18 ALB APOA1 APOA2 APOB APOE CETP
18 Golgi apparatus GO:0005794 10.1 ALB APOE COG2 LDLR PCSK9 SLC29A3

Biological processes related to Arcus Corneae according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Name GO ID Score Top Affiliating Genes
1 cholesterol homeostasis GO:0042632 9.96 APOA1 APOA2 APOB APOE APOM CETP
2 cellular oxidant detoxification GO:0098869 9.94 ALB APOE APOM UBIAD1
3 triglyceride metabolic process GO:0006641 9.92 APOA2 APOE CETP PCSK9
4 cholesterol efflux GO:0033344 9.92 APOA1 APOA2 APOB APOE APOM
5 low-density lipoprotein particle clearance GO:0034383 9.91 APOB LDLR LDLRAP1 PCSK9
6 reverse cholesterol transport GO:0043691 9.91 APOA1 APOA2 APOE APOM CETP LCAT
7 membrane organization GO:0061024 9.89 APOB LDLR LDLRAP1
8 platelet degranulation GO:0002576 9.89 ALB APOA1 FN1
9 high-density lipoprotein particle assembly GO:0034380 9.89 APOA1 APOA2 APOE APOM
10 chylomicron assembly GO:0034378 9.88 APOA1 APOA2 APOB APOE
11 low-density lipoprotein particle remodeling GO:0034374 9.88 APOA2 APOB APOE CETP LPA
12 phospholipid metabolic process GO:0006644 9.87 APOA1 LCAT PCSK9
13 cholesterol transport GO:0030301 9.87 APOA1 APOA2 APOB CETP LCAT LDLR
14 very-low-density lipoprotein particle remodeling GO:0034372 9.86 APOA1 APOE CETP LCAT
15 phospholipid transport GO:0015914 9.85 APOA1 CETP LDLR
16 chylomicron remodeling GO:0034371 9.85 APOA1 APOA2 APOB APOE
17 high-density lipoprotein particle clearance GO:0034384 9.85 APOA1 APOA2 APOE APOM LDLR
18 cholesterol metabolic process GO:0008203 9.85 APOA1 APOA2 APOB APOE APOL1 CETP
19 lipoprotein biosynthetic process GO:0042158 9.84 APOA1 APOB APOE LCAT
20 triglyceride homeostasis GO:0070328 9.83 APOA1 APOE CETP
21 phosphatidylcholine biosynthetic process GO:0006656 9.83 APOA1 APOA2 LCAT
22 triglyceride catabolic process GO:0019433 9.83 APOA1 APOB APOE
23 phospholipid efflux GO:0033700 9.81 APOA1 APOA2 APOE
24 positive regulation of cholesterol esterification GO:0010873 9.8 APOA1 APOA2 APOE
25 chylomicron remnant clearance GO:0034382 9.8 APOB APOE LDLR
26 lipoprotein catabolic process GO:0042159 9.78 APOB APOE LDLR
27 positive regulation of lipid biosynthetic process GO:0046889 9.71 APOA1 APOE
28 regulation of cholesterol metabolic process GO:0090181 9.71 APOE LDLR
29 phosphatidylcholine metabolic process GO:0046470 9.71 CETP LCAT
30 regulation of protein metabolic process GO:0051246 9.71 APOE LDLR
31 amyloid precursor protein metabolic process GO:0042982 9.7 APOE LDLRAP1
32 phospholipid homeostasis GO:0055091 9.7 APOA1 CETP
33 regulation of Cdc42 protein signal transduction GO:0032489 9.7 APOA1 APOE
34 regulation of cholesterol transport GO:0032374 9.69 APOA1 APOE
35 cholesterol import GO:0070508 9.69 APOA1 LDLR
36 negative regulation of cytokine secretion involved in immune response GO:0002740 9.69 APOA1 APOA2
37 peptidyl-methionine modification GO:0018206 9.68 APOA1 APOA2
38 very-low-density lipoprotein particle clearance GO:0034447 9.68 APOB APOE
39 regulation of intestinal cholesterol absorption GO:0030300 9.68 APOA1 APOA2
40 negative regulation of lipase activity GO:0060192 9.67 APOA1 APOA2
41 protein oxidation GO:0018158 9.67 APOA1 APOA2
42 negative regulation of very-low-density lipoprotein particle remodeling GO:0010903 9.67 APOA1 APOA2
43 receptor-mediated endocytosis involved in cholesterol transport GO:0090118 9.66 LDLR LDLRAP1
44 positive regulation of low-density lipoprotein particle receptor catabolic process GO:0032805 9.65 APOE PCSK9
45 response to caloric restriction GO:0061771 9.64 APOE LDLR
46 lipoprotein metabolic process GO:0042157 9.56 APOA1 APOA2 APOB APOE APOL1 APOM
47 high-density lipoprotein particle remodeling GO:0034375 9.17 ALB APOA1 APOA2 APOE APOM CETP
48 lipid metabolic process GO:0006629 10.19 APOA1 APOB APOE APOL1 CETP LCAT
49 post-translational protein modification GO:0043687 10.17 ALB APOA1 APOA2 APOB APOE APOL1
50 receptor-mediated endocytosis GO:0006898 10.13 ALB APOA1 APOB APOE APOL1 LDLR

Molecular functions related to Arcus Corneae according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 lipid binding GO:0008289 9.87 ALB APOA1 APOA2 APOB APOE APOL1
2 heparin binding GO:0008201 9.83 APOB APOE FN1 LPA
3 phospholipid binding GO:0005543 9.83 APOA1 APOA2 APOB APOE APOM
4 amyloid-beta binding GO:0001540 9.78 APOA1 APOE LDLR LDLRAP1
5 cholesterol binding GO:0015485 9.76 APOA1 APOA2 APOE CETP
6 antioxidant activity GO:0016209 9.67 ALB APOE APOM UBIAD1
7 phospholipid transporter activity GO:0005548 9.6 APOA1 CETP
8 apolipoprotein binding GO:0034185 9.58 LPA PCSK9
9 low-density lipoprotein particle binding GO:0030169 9.58 LDLR PCSK9
10 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.58 APOA1 APOA2 APOE
11 high-density lipoprotein particle binding GO:0008035 9.57 APOA1 APOA2
12 low-density lipoprotein particle receptor binding GO:0050750 9.56 APOB APOE LDLRAP1 PCSK9
13 lipase inhibitor activity GO:0055102 9.55 APOA1 APOA2
14 lipoprotein particle binding GO:0071813 9.54 APOA1 APOE
15 very-low-density lipoprotein particle receptor binding GO:0070326 9.51 APOE PCSK9
16 high-density lipoprotein particle receptor binding GO:0070653 9.49 APOA1 APOA2
17 cholesterol transporter activity GO:0017127 9.35 APOA1 APOA2 APOB APOE CETP
18 apolipoprotein receptor binding GO:0034190 9.33 APOA1 APOA2 PCSK9
19 lipid transporter activity GO:0005319 9.1 APOA1 APOA2 APOB APOE APOM CETP
20 protein binding GO:0005515 10.49 ALB APOA1 APOA2 APOB APOE APOL1
21 identical protein binding GO:0042802 10.07 ALB APOA1 APOE CRYAA FN1 LDLR

Sources for Arcus Corneae

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
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51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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